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研究者情報

データ更新日:2019年02月15日

上野 将也 (うえの まさや) 助教 UENO, Masaya

メール

所属組織・役職等

がん進展制御研究所 遺伝子・染色体構築研究分野

教育分野

所属研究室等

遺伝子・染色体構築

学歴

【取得学位】
修士(薬学)
博士(医学)

職歴

カリフォルニア大学 ポストドクトラルフェロー(2011/04/01-2013/09/30)
カリフォルニア大学 日本学術振興会 海外特別研究員(2009/04/01-2011/03/31)
大阪大学 微生物病研究所 助教(2006/04/01-2009/03/31)
金沢大学 がん研究所 助手(2001/05/01-2006/03/31)

生年月

1973年04月

所属学会

日本薬学会
日本血液学会
日本癌学会

学内委員会委員等

受賞学術賞

○Travel Grant, ISSCR Meeting (2012/06/14)
○Travel Grant, ISEH Meeting (2010/09/15)

専門分野

幹細胞

専門分野キーワード

血液腫瘍、造血発生、胎盤発生

研究課題

白血病の抗がん剤治療抵抗性における代謝シグナル機能の解明

著書

論文

  • Distinct roles of Rheb and Raptor in activating mTOR complex 1 for the self-renewal of hematopoietic stem cells. Peng H*, Kasada A*, Ueno M*, Hoshii T, Tadokoro Y, Nomura N, Ito C, Takase Y, Vu HT, Kobayashi M, Xiao B, Worley PF, Hirao A (*co-first authors). Biochem Biophys Res Commun. 2017
  • Hes1 suppresses acute myeloid leukemia development through FLT3 repression. Kato T, Sakata-Yanagimoto M, Nishikii H, Ueno M, Miyake Y, Yokoyama Y, Asabe Y, Kamada Y, Muto H, Obara N, Suzukawa K, Hasegawa Y, Kitabayashi I, Uchida K, Hirao A, Yagita H, Kageyama R, Chiba S. Leukemia 2015
  • c-Met-dependent multipotent labyrinth trophoblast progenitors establish placental exchange interface. Ueno M, Lee LK, Chhabra A, Kim YJ, Sasidharan R, Van Handel B, Wang Y, Kamata M, Kamran P, Sereti KI, Ardehali R, Jiang M, Mikkola HK. Dev Cell 2013
  • Essential role of endothelial class II PI3K-C2alpha in angiogenesis and vascular barrier function. Yoshioka K, Yoshida K, Cui H, Wakayama T, Takuwa N, OkamotoY, Du W, Qi X, Asanuma K, Sugihara K, Aki S, Miyazawa H, Biswas K, Nagakura C, Ueno M, Iseki S, Schwartz RJ, Okamoto H, Sasaki T, Matsui O, Asano M, Adams RH, Takakura N, Takuwa Y. Nat Med 2012
  • Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling.  Chhabra A, Lechner AJ, Ueno M, Acharya A, Van Handel B, Wang Y, Iruela-Arispe ML, Tallquist MD, Mikkola HK. Dev Cell 2012

全て表示

  • Functional dissection of hematopoietic stem cell populations with a stemness-monitoring system based on NS-GFP transgene expression. Ali MAE, Fuse K, Tadokoro Y, Hoshii T, Ueno M, Kobayashi M, Nomura N, Vu HT, Peng H, Hegazy AM, Masuko M, Sone H, Arai F, Tajima A, Hirao A. Sci Rep. 2017
  • Therapeutic Strategy for Targeting Aggressive Malignant Gliomas by Disrupting Their Energy Balance. Hegazy AM, Yamada D, Kobayashi M, Kohno S, Ueno M, Ali MA, Ohta K, Tadokoro Y, Ino Y, Todo T, Soga T, Takahashi C, Hirao A. J Biol Chem. 2016
  • Association of a murine leukaemia stem cell gene signature based on nucleostemin promoter activity with prognosis of acute myeloid leukaemia in patients. Ali MA, Naka K, Yoshida A, Fuse K, Kasada A, Hoshii T, Tadokoro Y, Ueno M, Ohta K, Kobayashi M, Takahashi C, Hirao A. Biochem Biophys Res Commun. 2014
  • Loss of Tsc1 accelerates malignant gliomagenesis when combined with oncogenic signals. Yamada D, Hoshii T, Tanaka S, Hegazy AM, Kobayashi M, Tadokoro Y, Ohta K, Ueno M, Ali MA, Hirao A. J Biochem. 2014
  • Requirement of SLD5 for early embryogenesis. Mohri T*, Ueno M*, Nagahama Y, Gong ZY, Asano M, Oshima H, Oshima M, Fujio Y, Takakura N (*co-first authors). PLoS One. 2013
  • Up-regulation of PSF1 promotes the growth of breast cancer cells. Nakahara I, Miyamoto M, Shibata T, Akashi-Tanaka S, Kinoshita T, Mogushi K, Oda K, Ueno M, Takakura N, Mizushima H, Tanaka H, Ohta T. Genes Cells. 2010
  • Hematopoietic stem cell development in the placenta. Gekas C, Rhodes KE, Vanhandel B, Chhabra A, Ueno M, Mikkola HK. Int J Dev Biol. 2010
  • Placenta as a newly identified source of hematopoietic stem cells.  Lee L, Ueno M, Van Handel BJ, Mikkola HK. Curr Opin Hematol.  2010
  • Cell populations with high levels of PSF1 transcriptional activity exhibit high tumorigenic and metastatic capacity in a mouse xenograft model. Nagahama Y, Ueno M, Miyamoto S, Morii E, Minami T, Mochizuki N, Saya H, Takakura N.  Cancer Res. 2010
  • PSF3 marks malignant colon cancer and has a role in cancer cell proliferation. Nagahama Y, Ueno M, Haraguchi N, Mori M, Takakura N. Biochem Biophys Res Commun. 2010
  • Identification and characterization of stem cell-specific transcription of PSF1 in spermatogenesis. Han Y, Ueno M, Nagahama Y, Takakura N. Biochem Biophys Res Commun.  2009
  • Both alleles of PSF1 are required for maintenance of pool size of immature hematopoietic cells and acute bone marrow regeneration. Ueno M, Itoh M, Sugihara K, Asano M, Takakura N. Blood 2008
  • Spatial and temporal role of the apelin/APJ system in the caliber size regulation of blood vessels during angiogenesis. Kidoya H, Ueno M, Yamada Y, Mochizuki N, Nakata M, Yano T, Fujii R, Takakura N. EMBO J. 2008
  • Involvement of MDR1 Function In Proliferation of Tumor Cells. Katoh SY, Ueno M, Takakura N. J Biochem. 2008
  • EphB4 overexpression on B16 melanoma cells affects arterial-venous patterning in tumor angiogenesis. Huang X, Yamada Y, Kidoya K, Naitoh H, Nagahama Y, Kong L, Katoh S, Ueno M, Takakura N. Cancer Res. 2007
  • Essential roles of the CC chemokine ligand 3-CC chemokine receptor 5 axis in bleomycin-induced pulmonary fibrosis through regulation of macrophage and fibrocyte infiltration. Ishida Y, Kimura A, Kondo T, Hayashi T, Ueno M, Takakura N, Matsushima K, Mukaida N. Am J Pathol. 2007
  • Differential cell division history between neutrophils and macrophages in their development from granulocyte-macrophage progenitors. Sugimoto Y, Katayama N, Masuya M, Miyata E, Ueno M, Ohishi K, Nishii K, Takakura N, Shiku H. Br J Hematol. 2006
  • Platelet derived growth factor receptor alpha is essential for establishing a microenvironment that supports definitive erythropoiesis. Li WL, Yamada Y, Ueno M, Nishikawa S, Nishikawa S, Takakura N. J Biochem. 2006
  • Identification and characterization of mouse PSF1-binding protein, SLD5. Kong L, Ueno M, Itoh M, Yoshioka K, Takakura N. Biochem Biophys Res Commun. 2005
  • PSF1 is Essential for Early Embryogenesis in Mice. Ueno M, Itoh M, Kong L, Sugihara K, Asano M, Takakura N. Mol Cell Biol. 2005
  • Hematopoietic cells regulate the angiogenic switch during tumorigenesis. Okamoto R, Ueno M, Yamada Y, Takahashi N, Sano H, Suda T, Takakura N. Blood 2005
  • Abnormal blood vessel development in mice lacking presenilin-1. Nakajima M, Yuasa S, Ueno M, Takakura N, Koseki H, Shirasawa T. Mech Dev. 2003
  • Regulation of hematopoietic development in the aorta-gonad-mesonephros region mediated by Lnk adaptor protein. Nobuhisa I, Takizawa M, Takaki S, Inoue H, Okita K, Ueno M, Takatsu K, Taga T. Mol Cell Biol. 2003
  • Genomic organization and characterization of the mouse ELYS gene. Okita K, Nobuhisa I, Takizawa M, Ueno M, Kimura N, Taga T. Biochem Biophys Res Commun. 2003
  • Requirement of gp130 signaling for the AGM hematopoiesis. Takizawa M, Nobuhisa I, Igarashi K, Ueno M, Nakashima K, Kitamura T, Taga T. Exp Hematol. 2003
  • Identification of a novel transcription factor, ELYS, expressed predominantly in mouse foetal haematopoietic tissues. Kimura N, Takizawa M, Okita K, Natori O, Igarashi K, Ueno M, Nakashima K, Nobuhisa I, Taga T. Genes Cells. 2002
  • Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7. Yanagisawa M, Nakashima K, Takeda K, Ochiai W, Takizawa T, Ueno M, Takizawa M, Shibuya H, Taga T. Genes Cells. 2001
  • Endomucin is expressed in embryonic dorsal aorta and is able to inhibit cell adhesion. Ueno M, Igarashi K, Kimura N, Okita K, Takizawa M, Nobuhisa I, Kojima T, Kitamura T, Samulowitz U, Vestweber D, Shimomura T, Suda T, Nakashima K, Taga T. Biochem Biophys Res Commun. 2001
  • Genomic organization, sequence and chromosomal localization of the mouse Tbr2 gene and a comparative study with Tbr1. Ueno M, Kimura N, Nakashima K, Saito-Ohara F, Inazawa J, Taga T. Gene 2000
  • Differential induction of JE/MCP-1 in subclones from a murine macrophage cell line, RAW 264.7: role of kappaB-3 binding protein. Ueno M, Sonoda Y, Funakoshi M, Mukaida N, Nose K, Kasahara T. Cytokine 2000
  • A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain. Kimura N, Nakashima K, Ueno M, Kiyama H, Taga T. Brain Res Dev Brain Res. 1999
  • A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains. Kimura N, Ueno M, Nakashima K, Taga T. J Biochem. 1999
  • A suppressive role of p125FAK protein tyrosine kinase in hydrogen peroxide-induced apoptosis of T98G cells.  Sonoda Y, Kasahara T, Yokota-Aizu E, Ueno M, Watanabe S. Biochem Biophys Res Commun. 1997

講演・口頭発表等

  • Placental trophoblasts regulate both primitive and definitive hematopoiesis during development.(会議名:ISEH 2010 Meeting)(2010)
  • HGF/c-Met signaling pathway governs syncytiotrophoblast stem cell maintenance and cell polarity during placental development.(会議名:ISSCR 10th Annual Meeting)(2012)

芸術・フィールドワーク

特許

○sld5遺伝子発現レベルを利用したがん幹細胞の同定法
○psf1遺伝子欠損動物及びその利用方法

共同研究希望テーマ

科研費

○基盤研究(C)「mTOR複合体2による白血病の治療耐性制御機構の解明」(2017-2019) 代表者
○基盤研究(C)「静止期制御因子を指標とした造血幹細胞不均一性の解明」(2014-2016) 代表者
○大阪癌研究者育成基金「がん幹細胞の自己複製の分子基盤の解明」(2008-2008) 代表者
○基盤研究(B)「生態学的適所における造血幹細胞分裂の分子基盤の解明」(2008-2011) 分担者
○若手研究(B)「PSF1およびSLD5の幹細胞分裂における機能解析」(2007-2008) 代表者
○特定領域研究「がん組織における血管リモデリング機構」(2005-2009) 分担者
○若手研究(B)「造血幹細胞に特異的に発現し機能する新規核因子NFREDの機能解析」(2005-2006) 代表者
○基盤研究(B)「造血幹細胞制御に関わる血管内皮細胞由来幹細胞因子の遺伝子プロファイリング」(2004-2007) 分担者
○金沢大学重点化経費「TIE2受容体により制御を受ける遺伝子の同定」(2003-2003) 代表者
○若手研究(B)「浸潤型血管内皮細胞および定常型血管内皮細胞の特異的生理活性に関わる遺伝子の同定」(2002-2003) 代表者
○特定領域研究「血管新生における分子基盤の解明とその制御」(2002-2004) 分担者
○基盤研究(B)「造血幹細胞の発生・自己複製に関わる分子クローニングとその機能解析」(2001-2003) 分担者

学域・学類担当授業科目

大学院担当授業科目

○幹細胞生物学特論(2017)
○幹細胞生物学特論(2017)
○がん研セミナー(2016)
○幹細胞生物学特論(2016)
○幹細胞生物学特論(2016)

他大学の客員教授

教育活動(FD)に関する研究

国際事業協力

留学生参加の社会活動

審議会等の参加

講演可能なテーマ

その他公的社会活動

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