堀 修 (ほり おさむ) 教授 HORI Osamu
所属組織・役職等
医薬保健研究域 医学系 神経解剖学 教授
医薬保健研究域長・学域長
教育分野
【学士課程】
医薬保健学域 医学類
【大学院前期課程】
医薬保健学総合研究科 医科学専攻
【大学院後期課程】
医薬保健学総合研究科 医学専攻
所属研究室等
神経解剖学 TEL:076-265-2162 FAX:076-234-4222
学歴
【出身大学】
大阪大学 医学部 医学科 1989/03 卒業
【取得学位】
博士(医学)
職歴
生年月
1962年11月
所属学会
日本解剖学会 理事(2019-2022)
日本生化学会
日本分子生物学会
日本神経科学会
日本神経化学会 理事(2019-2022)
学内委員会委員等
受賞学術賞
専門分野
神経解剖学・神経病理学
専門分野キーワード
グリア細胞、神経細胞死、小胞体ストレス
研究課題
中枢神経系細胞におけるストレス応答
神経細胞保護薬、抗ストレス薬の開発
著書
論文
- Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside Frontiers in Neuroscience 16巻 2022/07/07 研究論文(学術雑誌)
- ATF6β Deficiency Elicits Anxiety-like Behavior and Hyperactivity Under Stress Conditions Neurochemical Research 2023/02/28 研究論文(学術雑誌)
- Localized astrogenesis regulates gyrification of the cerebral cortex. Science Advances 8巻 10号 eabi5209頁 2022/03/11 査読有 研究論文(学術雑誌)
- Isolation of ferret astrocytes reveals their morphological, transcriptional, and functional differences from mouse astrocytes Frontiers in Cellular Neuroscience 16巻 2022/10/06 研究論文(学術雑誌)
- The ATF6β-calreticulin axis promotes neuronal survival under endoplasmic reticulum stress and excitotoxicity. Scientific reports 11巻 1号 13086頁 2021/06/22 研究論文(学術雑誌)
- Brain injury triggers cell‐type‐specific and time‐dependent endoplasmic reticulum stress responses Glia 2022/11/22 研究論文(学術雑誌)
- Deletion of CD38 Suppresses Glial Activation and Neuroinflammation in a Mouse Model of Demyelination. Frontiers in cellular neuroscience 13巻 258号 258頁 2019 査読有
- Caspase-1 initiates apoptosis in the absence of gasdermin D. Tsuchiya K,Nakajima S,Hosojima S,Thi Nguyen D,Hattori T,Manh Le T,Hori O,Mahib MR,Yamaguchi Y,Miura M,Kinoshita T,Kushiyama H,Sakurai M,Shiroishi T,Suda T Nat Commun. 10巻 1号 2091頁 2019/05 査読有
- N-myc downstream-regulated gene 2 protects blood–brain barrier integrity following cerebral ischemia GLIA 66巻 7号 1432頁 2018/07/01 査読有 研究論文(学術雑誌)
- Abnormal social behavior and altered gene expression in mice lacking NDRG2. Neuroscience letters 743巻 135563頁 2021/01/19 研究論文(学術雑誌)
- Deletion of CD38 and supplementation of NAD+ attenuate axon degeneration in a mouse facial nerve axotomy model. Scientific reports 10巻 1号 17795頁 2020/10/20 研究論文(学術雑誌)
- Deletion of Atf6 alpha impairs astroglial activation and enhances neuronal death following brain ischemia in mice JOURNAL OF NEUROCHEMISTRY 132巻 3号 342-353頁 2015/01/01
- Soluble receptor for advanced glycation end products as a biomarker of symptomatic vasospasm in subarachnoid hemorrhage. Aida Y,Kamide T,Ishii H,Kitao Y,Uchiyama N,Nakada M,Hori O J Neurosurg 1頁 2019/11 査読有
- SERP1/RAMP4 stabilizes membrane proteins during stress and facilitates subsequent glycosylation. Yamaguchi, A., Hori, O.ほか4名 JOURNAL OF CELL BIOLOGY 147巻 1195-1204頁 1999/12 査読有 原著論文 研究論文(学術雑誌)
- Transmission of cell stress from endoplasmic reticulum to mitochondria: enhanced expression of Lon protease Hori, O., Ichinoda, F., ほか11名 JOURNAL OF CELL BIOLOGY 157巻 1151-1160頁 2002/06 査読有 原著論文 研究論文(学術雑誌)
- ATF6alpha Promotes Astroglial Activation and Neuronal Survival in a Chronic Mouse Model of Parkinson's Disease PLOS ONE 7巻 10号 e47950頁 2012/10 査読有 研究論文(学術雑誌)
- Cyclic ADP-ribose as an endogenous inhibitor of the mTOR pathway downstream of dopamine receptors in the mouse striatum. Journal of neural transmission (Vienna, Austria : 1996) 125巻 1号 17頁 2018/01 査読有 研究論文(学術雑誌)
- ORP150 protects against hypoxia/ischemia-induced neuronal death. Tamatani, M., Hori, O., ほか14名 NATURE MEDICINE 7巻 317-323頁 2001/12 査読有 原著論文 研究論文(学術雑誌)
- Role of Herp in the endoplasmic reticulum stress response. Hori O, Ogawa S他10名 GENES TO CELLS 9巻 5号 457-469頁 2004/05 査読有 原著論文 研究論文(学術雑誌)
- Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum (ER) translocation sites, leads to ER stress. 26頁 2006 査読有 原著論文
- Does ORP150/HSP12A protect dopaminergic neurons against MPTP/MPP(+)-induced neurotoxicity? 9, 589-595巻 2007 査読有 原著論文
- Methoxyflavones protect cells against endoplasmic reticulum (ER) stress and neurotoxin. 292巻 1, C353-C361号 2007 査読有 原著論文
- Vaticanol B, a resveratrol tetramer, regulates endoplasmic reticulum (ER) stress and inflammation. 293巻 1号 C411-8頁 2007 査読有 原著論文
- A dibenzoylmethane (DBM) derivative protects dopaminergic neurons against both oxidative stress and endoplamic reticulum (ER) stress. 293巻 6, C1884-94号 2007 査読有 原著論文
- Inactivation of brain mitochondrial Lon protease by peroxynitrite precedes electron transport chain dysfunction. 2008 査読有 原著論文
- Expression of the oxygen-regulated protein ORP150 accelerates wound healing by modulating intracellular VEGF transport JOURNAL OF CLINICAL INVESTIGATION 108巻 1号 41頁 2001/07 査読有 研究論文(学術雑誌)
- Expression of a novel RNA-splicing factor, RA301/Tra2 beta, in vascular lesions and its role in smooth muscle cell proliferation AMERICAN JOURNAL OF PATHOLOGY 158巻 5号 1685頁 2001/05 査読有 研究論文(学術雑誌)
- ORP150 protects against hypoxia/ischemia-induced neuronal death NATURE MEDICINE 7巻 3号 317頁 2001/03 査読無 研究論文(学術雑誌)
- Amyloid beta-peptide-binding alcohol dehydrogenase is a component of the cellular response to nutritional stress JOURNAL OF BIOLOGICAL CHEMISTRY 275巻 35号 27100頁 2000/09 査読有 研究論文(学術雑誌)
- 150-kDa oxygen-regulated protein (ORP150) functions as a novel molecular chaperone in MDCK cells AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 278巻 6号 C1172頁 2000/06 査読有 研究論文(学術雑誌)
- ORP150 (150 kDa Oxygen Regulated Protein) suppresses hypoxia-induced cell death. FRONTIERS OF THE MECHANISMS OF MEMORY AND DEMENTIA 1200号 61頁 2000 査読有 研究論文(プロシーディング)
- Exposure of cultured primary rat astrocytes to hypoxia results in intracellular glucose depletion and induction of glycolytic enzymes. NIITSU Y,HORI O,YAMAGUCHI A,BANDO Y,OZAWA K,TAMATANI M,OGAWA S,TOHYAMA M Mol. Brain Res. 74巻 1/2号 26頁 1999 査読無
- Induction of 72-kDa inducible heat shock protein (HSP72) in cultured rat astrocytes after energy depletion JOURNAL OF NEUROCHEMISTRY 70巻 2号 550頁 1998/02 査読無 研究論文(学術雑誌)
- Adsorption of circulating denDritic and monocytic cells by textured surface left ventricular assist devices: A model for sustained cellular activation of procoagulant and proinflammatory responses CIRCULATION 94巻 8号 4061頁 1996/10 査読無
- Expression of mitochondrial tricarboxylate carrier TCC mRNA and protein in the rat brain MOLECULAR BRAIN RESEARCH 100巻 1-2号 67頁 2002/04 査読有 研究論文(学術雑誌)
- Immunohistochemical detection of the 150-kDa oxygen-regulated protein in bladder cancer BJU INTERNATIONAL 90巻 4号 462頁 2002/09 査読無 研究論文(学術雑誌)
- A novel presenilin-2 splice variant in human Alzheimer's disease brain tissue JOURNAL OF NEUROCHEMISTRY 72巻 6号 2498頁 1999/06 査読有 研究論文(学術雑誌)
- Stress-associated endoplasmic reticulum protein 1 (SERP1)/ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation JOURNAL OF CELL BIOLOGY 147巻 6号 1195頁 1999/12 査読無 研究論文(学術雑誌)
- Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases Nature 405巻 6784号 354頁 2000/05/18 査読有 研究論文(学術雑誌)
- Antitumor effect of reduction of 150-kDa oxygen-regulated protein expression in human prostate cancer cells Molecular Urology 5巻 2号 79頁 2001 査読有 研究論文(学術雑誌)
- The receptor for advanced glycation end-products has a central role in mediating the effects of advanced glycation end-products on the development of vascular disease in diabetes mellitus NEPHROLOGY DIALYSIS TRANSPLANTATION 11巻 13頁 1996 査読有 研究論文(学術雑誌)
- THE MONONUCLEAR PHAGOCYTE INTERACTION SITE OF BETA-2-MICROGLOBULIN MODIFIED BY GLYCATION IS THE RECEPTOR FOR ADVANCED GLYCATION ENDPRODUCTS CIRCULATION 90巻 4号 233頁 1994/10 査読無
- Purification and characterization of a novel stress protein, the 150-kDa oxygen-regulated protein (ORP150), from cultured rat astrocytes and its expression in ischemic mouse brain JOURNAL OF BIOLOGICAL CHEMISTRY 271巻 9号 5025頁 1996/03 査読無 研究論文(学術雑誌)
- Exposure of astrocytes to hypoxia reoxygenation enhances expression of glucose-regulated protein 78 facilitating astrocyte release of the neuroprotective cytokine interleukin 6 JOURNAL OF NEUROCHEMISTRY 66巻 3号 973頁 1996/03 査読有 研究論文(学術雑誌)
- RAGE - A novel cellular receptor for advanced glycation end products DIABETES 45巻 S77頁 1996/07 査読有 研究論文(学術雑誌)
- Activation of the receptor for advanced glycation end products triggers a p21(ras)-dependent mitogen-activated protein kinase pathway regulated by oxidant stress JOURNAL OF BIOLOGICAL CHEMISTRY 272巻 28号 17810頁 1997/07 査読有 研究論文(学術雑誌)
- The receptor for advanced glycation end products (RAGE) is a central mediator of the interaction of AGE-beta(2)microglobulin with human mononuclear phagocytes via an oxidant-sensitive pathway - Implications for the pathogenesis of dialysis-related amyloidosis JOURNAL OF CLINICAL INVESTIGATION 98巻 5号 1088頁 1996/09 査読有 研究論文(学術雑誌)
- Potentiating effect of morphine upon d-methamphetamine-induced hyperthermia in mice. Effects of naloxone and haloperidol Pharmacology, Biochemistry and Behavior 36巻 2号 345頁 1990 査読有 研究論文(学術雑誌)
- THE RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS (RAGE) IS A CELLULAR-BINDING SITE FOR AMPHOTERIN - MEDIATION OF NEURITE OUTGROWTH AND COEXPRESSION OF RAGE AND AMPHOTERIN IN THE DEVELOPING NERVOUS-SYSTEM JOURNAL OF BIOLOGICAL CHEMISTRY 270巻 43号 25752頁 1995/10 査読有 研究論文(学術雑誌)
- HYPOXIA/REOXYGENATION-MEDIATED INDUCTION OF ASTROCYTE INTERLEUKIN-6 - A PARACRINE MECHANISM POTENTIALLY ENHANCING NEURON SURVIVAL JOURNAL OF EXPERIMENTAL MEDICINE 180巻 6号 2297頁 1994/12 査読無 研究論文(学術雑誌)
- ADVANCED GLYCATION END-PRODUCTS (AGES) ON THE SURFACE OF DIABETIC ERYTHROCYTES BIND TO THE VESSEL WALL VIA A SPECIFIC RECEPTOR INDUCING OXIDANT STRESS IN THE VASCULATURE - A LINK BETWEEN SURFACE-ASSOCIATED AGES AND DIABETIC COMPLICATIONS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91巻 16号 7742頁 1994/08 査読有 研究論文(学術雑誌)
- METABOLIC AND BIOSYNTHETIC ALTERATIONS IN CULTURED ASTROCYTES EXPOSED TO HYPOXIA REOXYGENATION JOURNAL OF NEUROCHEMISTRY 62巻 4号 1489頁 1994/04 査読有 研究論文(学術雑誌)
- Regulation of tumor angiogenesis by oxygen-regulated protein 150, an inducible endoplasmic reticulum chaperone CANCER RESEARCH 61巻 10号 4206頁 2001/05 査読有 研究論文(学術雑誌)
- Peg3/Pw1 is involved in p53-mediated cell death pathway in brain ischemia/hypoxia JOURNAL OF BIOLOGICAL CHEMISTRY 277巻 1号 623頁 2002/01 査読有 研究論文(学術雑誌)
- Expression of 150-kd oxygen-regulated protein in the hippocampus suppresses delayed neuronal cell death JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 22巻 8号 979頁 2002/08 査読有 研究論文(学術雑誌)
- Transmission of cell stress from endoplasmic reticulum to mitochondria Journal of Cell Biology 157巻 7号 1151頁 2002/06/24 査読有 研究論文(学術雑誌)
- Expression of the endoplasmic reticulum molecular chaperone (ORP150) rescues hippocampal neurons from glutamate toxicity. Kitao Y,Ozawa K,Miyazaki M,Tamatani M,Kobayashi T,Yanagi H,Okabe M,Ikawa M,Yamashima T,Stern DM,Hori O,Ogawa S J Clin Invest. 108巻 10号 1439頁 2001/11 査読有 研究論文(学術雑誌)
- Antitumor effect of reduction of 150-kDa oxygen-regulated protein expression on human prostate cancer cells INTERNATIONAL JOURNAL OF UROLOGY 9巻 10号 577頁 2002/10 査読有 研究論文(学術雑誌)
- The effect of Ndrg2 expression on astroglial activation NEUROCHEMISTRY INTERNATIONAL 59巻 1号 21頁 2011/08 査読有 研究論文(学術雑誌)
- A dibenzoylmethane derivative protects H2O2-induced cell death and inhibits lipopolysaccharide- induced NO production in cultured rat astrocytes. 高野 桂 Journal of Neuroscience Research 89巻 955頁 2011/03 査読有
- Glutamate Preferentially Suppresses Osteoblastogenesis Than Adipogenesis Through the Cystine/Glutamate Antiporter in Mesenchymal Stem Cells JOURNAL OF CELLULAR PHYSIOLOGY 226巻 3号 652頁 2011/03 査読有 研究論文(学術雑誌)
- Cellular stress responses: Cell survival and cell death International Journal of Cell Biology 2010巻 214074頁 2010 査読有
- Editorial: Cell stress and cell death International Journal of Cell Biology 2010巻 245803頁 2010 査読有 研究論文(学術雑誌)
- Ascorbic acid partly antagonizes resveratrol mediated heme oxygenase-1 but not paraoxonase-1 induction in cultured hepatocytes - role of the redox-regulated transcription factor Nrf2 BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE 11巻 1頁 2010/01 査読有 研究論文(学術雑誌)
- [Analysis of astrocyte-derived stress-related genes]. Hori O Kaibogaku zasshi. Journal of anatomy 84巻 4号 113頁 2009/12 査読有
- RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106巻 47号 20021頁 2009/11 査読有 研究論文(学術雑誌)
- A dibenzoylmethane derivative protects dopaminergic neurons against both oxidative stress and endoplasmic reticulum stress AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 293巻 6号 C1884頁 2007/12 査読有 研究論文(学術雑誌)
- Ischemia-induced neuronal cell death and stress response ANTIOXIDANTS & REDOX SIGNALING 9巻 5号 573頁 2007/05 査読無
- Does ORP150/HSP12A protect dopaminergic neurons against MPTP/MPP+-induced neurotoxicity? ANTIOXIDANTS & REDOX SIGNALING 9巻 5号 589頁 2007/05 査読無 研究論文(学術雑誌)
- Methoxyflavones protect cells against endoplasmic reticulum stress and neurotoxin AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 292巻 1号 C353頁 2007/01 査読無 研究論文(学術雑誌)
- [Neuronal cell death and stress response]. Seikagaku. The Journal of Japanese Biochemical Society 78巻 10号 973頁 2006/10 査読有 研究論文(学術雑誌)
- The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes DIABETES 54巻 3号 657頁 2005/03 査読有 研究論文(学術雑誌)
- ORP150/HSP12A protects renal tubular epithelium from ischemia-induced cell death FASEB JOURNAL 18巻 10号 1401頁 2004/07 査読有 研究論文(学術雑誌)
- ORP150/HSP12A regulates Purkinje cell survival: A role for endoplasmic reticulum stress in cerebellar development JOURNAL OF NEUROSCIENCE 24巻 6号 1486頁 2004/02 査読有 研究論文(学術雑誌)
- Hypoxia/ischemia-induced neuronal death is caused by stress from endoplasmic reticulum JOURNAL OF NEUROCHEMISTRY 87巻 25頁 2003/12 査読無
- MPEG-7の概要 堀 修 映像情報メディア学会誌 : 映像情報メディア = The journal of the Institute of Image Information and Television Engineers 56巻 11号 1708頁 2002/11/01
- Forum original research communication - Hypoxia-mediated induction of herne oxygenase type I and carbon monoxide release from astrocytes protects nearby cerebral neurons from hypoxia-mediated apoptosis ANTIOXIDANTS & REDOX SIGNALING 9巻 5号 543頁 2007/05 査読無 研究論文(学術雑誌)
- Methoxyflavones protect cells against endoplasmic reticulum (ER) stress and neurotoxin. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 127巻 186頁 2007 査読有 研究論文(学術雑誌)
- Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation. Human molecular genetics 16巻 1号 50頁 2007/01/01 査読無 研究論文(学術雑誌)
- A rat model of human FENIB (familial encephalopathy with neuroserpin inclusion bodies). Biochemical and biophysical research communications 346巻 3号 1040頁 2006/08/04 査読無 研究論文(学術雑誌)
- Role of Herp in the endoplasmic reticulum stress response. Genes to cells : devoted to molecular & cellular mechanisms 9巻 5号 457頁 2004/05 査読無 研究論文(学術雑誌)
- Plasma Corticosterone Activates SGK1 and Induces Morphological Changes in Oligodendrocytes in Corpus Callosum PLOS ONE 6巻 5号 e19859頁 2011/05 査読有 研究論文(学術雑誌)
- Efficacy of Dibenzoylmethane Derivatives in Protecting against Endoplasmic Reticulum Stress and Inhibiting Nuclear Factor Kappa B on Dextran Sulfate Sodium Induced Colitis in Mice BIOLOGICAL & PHARMACEUTICAL BULLETIN 33巻 12号 2029頁 2010/12 査読有 研究論文(学術雑誌)
- Suppression of Expression of Endoplasmic Reticulum Chaperones by Helicobacter pylori and Its Role in Exacerbation of Non-steroidal Anti-inflammatory Drug-induced Gastric Lesions JOURNAL OF BIOLOGICAL CHEMISTRY 285巻 48号 37302頁 2010/11 査読有 研究論文(学術雑誌)
- Deletion of Herp facilitates degradation of cytosolic proteins GENES TO CELLS 15巻 8号 843頁 2010/08 査読有 研究論文(学術雑誌)
- Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum (ER) translocation sites, leads to ER stress. Molecular and cellular biology 26巻 11号 4257頁 2006/06 査読無 研究論文(学術雑誌)
- Gene therapy for prostate cancer using the cytosine deaminase/uracil phosphoribosyttransferase suicide system JOURNAL OF GENE MEDICINE 5巻 1号 30頁 2003/01 査読有 研究論文(学術雑誌)
- A Carbazole Derivative Protects Cells Against Endoplasmic Reticulum (ER) Stress and Glutathione Depletion JOURNAL OF PHARMACOLOGICAL SCIENCES 108巻 2号 164頁 2008/10 査読無 研究論文(学術雑誌)
- Inactivation of brain mitochondrial Lon protease by peroxynitrite precedes electron transport chain dysfunction NEUROCHEMISTRY INTERNATIONAL 53巻 3-4号 95頁 2008/09 査読無 研究論文(学術雑誌)
- A novel inhibitor of advanced glycation and endoplasmic reticulum stress reduces infarct volume in rat focal cerebral ischemia BRAIN RESEARCH 1183巻 124頁 2007/12 査読無 研究論文(学術雑誌)
- Vaticanol B, a resveratrol tetramer, regulates endoplasmic reticulum stress and inflammation AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 293巻 1号 C411頁 2007/07 査読無 研究論文(学術雑誌)
- ANTIOXIDANT EFFECTS OF THE HYDROXY GROUPS IN THE SIMPLE PHENOLIC CARBAZOLES Hieda Yuhzo,Hatae Noriyuki,Anraku Makoto,Matsuura Nobuyasu,Uemura Kazuhide,Hibino Satoshi,Choshi Tominari,Tomida Hisao,Hori Osamu,Fujioka Haruto HETEROCYCLES 92巻 1号 120頁 2016 査読有 研究論文(学術雑誌)
- 脳虚血において内在性分泌型RAGEはデコイ受容体として機能し神経細胞を保護する 山本 靖彦,清水 有,原島 愛,棟居 聖一,大石 正博,林 康彦,中田 光俊,北尾 康子,堀 修,山本 博 日本抗加齢医学会総会プログラム・抄録集 16回巻 172頁 2016/06
- Atf6α deficiency suppresses microglial activation and ameliorates pathology of experimental autoimmune encephalomyelitis. Ta HM,Le TM,Ishii H,Takarada-Iemata M,Hattori T,Hashida K,Yamamoto Y,Mori K,Takahashi R,Kitao Y,Hori O Journal of neurochemistry 139巻 6号 1124頁 2016/12 査読有 研究論文(学術雑誌)
- CD38 positively regulates postnatal development of astrocytes cell-autonomously and oligodendrocytes non-cell-autonomously GLIA 65巻 6号 974頁 2017/06 査読有 研究論文(学術雑誌)
- 小胞体からはじまる多彩なシグナルと包括的生命機能制御 網膜神経細胞死における小胞体ストレス応答の役割 宝田 美佳,郡山 恵樹,森 和俊,堀 修 生命科学系学会合同年次大会 2017年度巻 [3PW17頁 2017/12
- Deletion of Atf6α enhances kainate-induced neuronal death in mice. Kezuka D,Tkarada-Iemata M,Hattori T,Mori K,Takahashi R,Kitao Y,Hori O Neurochemistry international 92巻 67頁 2016/01 査読有 研究論文(学術雑誌)
- Deletion of Herpud1 Enhances Heme Oxygenase-1 Expression in a Mouse Model of Parkinson's Disease PARKINSONS DISEASE 2016巻 6163934頁 2016 査読有 研究論文(学術雑誌)
- Transgenic supplementation of SIRT1 fails to alleviate acute loss of nigrostriatal dopamine neurons and gliosis in a mouse model of MPTP-induced parkinsonism F1000Research 4巻 130頁 2015/05/27 査読有 研究論文(学術雑誌)
- Alterations in dendrite and spine morphology of cortical pyramidal neurons in DISC1-binding zinc finger protein (DBZ) knockout mice FRONTIERS IN NEUROANATOMY 9巻 52頁 2015/04 査読有 研究論文(学術雑誌)
- Deletion of Atf6α impairs astroglial activation and enhances neuronal death following brain ischemia in mice. Yoshikawa A,Kamide T,Hashida K,Ta HM,Inahata Y,Takarada-Iemata M,Hattori T,Mori K,Takahashi R,Matsuyama T,Hayashi Y,Kitao Y,Hori O Journal of neurochemistry 132巻 3号 342頁 2015/02 査読有 研究論文(学術雑誌)
- Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease FRONTIERS IN BEHAVIORAL NEUROSCIENCE 8巻 133頁 2014/04 査読有 研究論文(学術雑誌)
- 3,4-Dihydroxybenzalacetone Protects Against Parkinson's Disease-Related Neurotoxin 6-OHDA Through Akt/Nrf2/Glutathione Pathway JOURNAL OF CELLULAR BIOCHEMISTRY 115巻 1号 151頁 2014/01 査読有 研究論文(学術雑誌)
- Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness. Kondo T,Asai M,Tsukita K,Kutoku Y,Ohsawa Y,Sunada Y,Imamura K,Egawa N,Yahata N,Okita K,Takahashi K,Asaka I,Aoi T,Watanabe A,Watanabe K,Kadoya C,Nakano R,Watanabe D,Maruyama K,Hori O,Hibino S,Choshi T,Nakahata T,Hioki H,Kaneko T,Naitoh M,Yoshikawa K,Yamawaki S,Suzuki S,Hata R,Ueno S,Seki T,Kobayashi K,Toda T,Murakami K,Irie K,Klein WL,Mori H,Asada T,Takahashi R,Iwata N,Yamanaka S,Inoue H Cell stem cell 12巻 4号 487頁 2013/04 査読有 研究論文(学術雑誌)
- Displays of paternal mouse pup retrieval following communicative interaction with maternal mates NATURE COMMUNICATIONS 4巻 1346頁 2013/01 査読有 研究論文(学術雑誌)
- Inhibition of nuclear factor-κB p65 phosphorylation by 3,4-dihydroxybenzalacetone and caffeic acid phenethyl ester. Takakura K,Takatou S,Tomiyama R,Le TM,Nguyen DT,Nakamura Y,Konishi T,Matsugo S,Hori O Journal of pharmacological sciences 137巻 3号 248頁 2018/07 査読有
- A dibenzoylmethane derivative inhibits lipopolysaccharide-induced NO production in mouse microglial cell line BV-2. Takano K,Ishida N,Kawabe K,Moriyama M,Hibino S,Choshi T,Hori O,Nakamura Y Neurochemistry international 119巻 126頁 2018/10 査読有
- Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice. Communications biology 2巻 76号 76頁 2019 査読有 研究論文(学術雑誌)
- Ndrg2 deficiency ameliorates neurodegeneration in experimental autoimmune encephalomyelitis Journal of Neurochemistry 145巻 2号 139頁 2018/04/01 査読有 研究論文(学術雑誌)
- 3,4-dihydroxybenzalacetone and caffeic acid phenethyl ester induce preconditioning ER stress and autophagy in SH-SY5Y cells JOURNAL OF CELLULAR PHYSIOLOGY 233巻 2号 1671頁 2018/02 査読有 研究論文(学術雑誌)
- The role of Ndrg2 on astroglial activation in stab wound injury model JOURNAL OF NEUROCHEMISTRY 125巻 121頁 2013/05 査読無
- Impairment of endoplasmic reticulum in liver as an early consequence of the systemic inflammatory response in rats AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 303巻 12号 G1373頁 2012/12 査読有 研究論文(学術雑誌)
- Association fibers connecting the Broca center and the lateral superior frontal gyrus: a microsurgical and tractographic anatomy JOURNAL OF NEUROSURGERY 116巻 2号 323頁 2012/02 査読有 研究論文(学術雑誌)
- RAGE mediates vascular injury and inflammation after global cerebral ischemia NEUROCHEMISTRY INTERNATIONAL 60巻 3号 220頁 2012/02 査読有 研究論文(学術雑誌)
- α-Lipoic acid (LA) enantiomers protect SH-SY5Y cells against glutathione depletion. Yamada T,Hashida K,Takarada-Iemata M,Matsugo S,Hori O Neurochemistry international 59巻 7号 1003頁 2011/12 査読有 研究論文(学術雑誌)
- Antioxidant effects of the highly-substituted carbazole alkaloids and their related carbazoles BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24巻 15号 3530頁 2014/08 査読有 研究論文(学術雑誌)
- Deletion of N-myc downstream-regulated gene 2 attenuates reactive astrogliosis and inflammatory response in a mouse model of cortical stab injury JOURNAL OF NEUROCHEMISTRY 130巻 3号 374頁 2014/08 査読有 研究論文(学術雑誌)
- 内在性分泌型RAGEは血管脳関門を越えてデコイ受容体としての神経細胞保護作用を発揮する 清水 有,山本 靖彦,原島 愛,棟居 聖一,大石 正博,林 康彦,北尾 康子,堀 修,山本 博 日本生化学会大会プログラム・講演要旨集 87回巻 [4T15p頁 2014/10
- 中枢神経・認知症 内在性分泌型RAGEは脳虚血から神経細胞を保護する 清水 有,山本 靖彦,原島 愛,棟居 聖一,大石 正博,林 康彦,中田 光俊,北尾 康子,堀 修,山本 博 糖尿病合併症 29巻 Suppl.1号 197頁 2015/11 査読無
- Pre-administration of low-dose methamphetamine enhances movement and neural activity after high-dose methamphetamine administration in the striatum. Takeichi T,Hori O,Hattori T,Kiryu K,Zuka M,Kitamura O Neurosci Lett. 703巻 119頁 2019/06 査読有
- Microglial activation in the cochlear nucleus after early hearing loss in rats. Noda M,Hatano M,Hattori T,Takarada-Iemata M,Shinozaki T,Sugimoto H,Ito M,Yoshizaki T,Hori O Auris Nasus Larynx. 46巻 5号 716頁 2019/10 査読有 研究論文(学術雑誌)
- CD38, CD157, and RAGE as Molecular Determinants for Social Behavior. Higashida H,Hashii M,Tanaka Y,Matsukawa S,Higuchi Y,Gabata R,Tsubomoto M,Seishima N,Teramachi M,Kamijima T,Hattori T,Hori O,Tsuji C,Cherepanov SM,Shabalova AA,Gerasimenko M,Minami K,Yokoyama S,Munesue SI,Harashima A,Yamamoto Y,Salmina AB,Lopatina O Cells 9巻 1号 2019/12 査読有
- Does the superior fronto-occipital fascicle exist in the human brain? Fiber dissection and brain functional mapping in 90 patients with gliomas NeuroImage: Clinical 25巻 102192頁 2020 研究論文(学術雑誌)
- Neuroprotective Effects of Endogenous Secretory Receptor for Advanced Glycation End-products in Brain Ischemia. Aging and disease 11巻 3号 547頁 2020/05 査読有 研究論文(学術雑誌)
- Direct evidence of the relationship between brain metastatic adenocarcinoma and white matter fibers: A fiber dissection and diffusion tensor imaging tractography study Journal of Clinical Neuroscience 77巻 55頁 2020/07 研究論文(学術雑誌)
- Astrocytes in the pathogenesis of multiple sclerosis Folia Pharmacologica Japonica 156巻 4号 230頁 2021 研究論文(学術雑誌)
- RAGE signaling antagonist suppresses mouse macrophage foam cell formation. Biochemical and biophysical research communications 555巻 74頁 2021/05/28 研究論文(学術雑誌)
- Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide-induced microglial and astrocytic neuroinflammation by increasing NAD. Journal of neurochemistry 158巻 2号 311頁 2021/07 研究論文(学術雑誌)
- Pyramid-Shape Crossings and Intercrossing Fibers Are Key Elements for Construction of the Neural Network in the Superficial White Matter of the Human Cerebrum Cerebral Cortex 30巻 10号 5218頁 2020/09/03 研究論文(学術雑誌)
- [Astrocytes in the pathogenesis of multiple sclerosis]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica 156巻 4号 230頁 2021 研究論文(学術雑誌)
- Displays of paternal mouse pup retrieval following communicative interaction with maternal mates Liu HX, Lopatina O, Higashida C, Fujimoto H, Akther S, Inzhutova A, Liang M, Zhong J, Tsuji T, Yoshihara T, Sumi K, Ishiyama M, Ma WJ, Ozaki M, Yagitani S, Yokoyama S, Mukaida N, Sakurai T, Hori O, Yoshioka K, Hirao A, Kato Y, Ishihara K, Kato I, Okamoto H, Cherepanov SM, Salmina AB, Hirai H, Asano M, Brown DA, Nagano I, Higashida H Nat Commun 2013 査読有 原著論文 研究論文(学術雑誌)
- Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness Kondo T, Asai M, Tsukita K, Kutoku Y, Ohsawa Y, Sunada Y, Imamura K, Egawa N, Yahata N, Okita K, Takahashi K, Asaka I, Aoi T, Watanabe A, Watanabe K, Kadoya C, Nakano R, Watanabe D, Maruyama K, Hori O, Hibino S, Choshi T, Nakahata T, Hioki H, Kaneko T, Naitoh M, Yoshikawa K, Yamawaki S, Suzuki S, Hata R, Ueno S, Seki T, Kobayashi K, Toda T, Murakami K, Irie K, Klein WL, Mori H, Asada T, Takahashi R, Iwata N, Yamanaka S, Inoue H. Cell Stem Cell 2013 査読有 原著論文 研究論文(学術雑誌)
- 3,4-dihydroxybenzalacetone protects against Parkinson's disease-related neurotoxin 6-OHDA through Akt/Nrf2/glutathione pathway Gunjima K, Tomiyama R, Takakura K, Yamada T, Hashida K, Nakamura Y, Konishi T, Matsugo S, Hori O J Cell Biochem 2014 査読有 原著論文
- Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease Lopatina O, Yoshihara T, Nishimura T, Zhong J, Akther S, Fakhrul AA, Liang M, Higashida C, Sumi K, Furuhara K, Inahata Y, Huang JJ, Koizumi K, Yokoyama S, Tsuji T, Petugina Y, Sumarokov A, Salmina AB, Hashida K, Kitao Y, Hori O, Asano M, Kitamura Y, Kozaka T, Shiba K, Zhong F, Xie MJ, Sato M, Ishihara K, Higashida H Front Behav Neurosci 2014 査読有 原著論文
- Alterations in dendrite and spine morphology of cortical pyramidal neurons in DISC1-binding zinc finger protein (DBZ) knockout mice Koyama Y, Hattori T, Nishida T, Hori O, Tohyama M Front Neuroanat 2015 査読有 原著論文
- Deletion of Herpud1 Enhances Heme Oxygenase-1 Expression in a Mouse Model of Parkinson's Disease Parkinsons Disease 2016 査読有 原著論文 研究論文(学術雑誌)
- Transgenic supplementation of SIRT1 fails to alleviate acute loss of nigrostriatal dopamine neurons and gliosis in a mouse model of MPTP-induced parkinsonism F1000Research 2015 査読有 研究論文(学術雑誌)
- Deletion of N-myc downstream-regulated gene 2 attenuates reactive astrogliosis and inflammatory response in a mouse model of cortical stab injury Journal of Neurochemistry 130巻 3号 374-387頁 2014/01/01
- ATF6alpha Promotes Astroglial Activation and Neuronal Survival in a Chronic Mouse Model of Parkinson's Disease PLoS ONE 7巻 10号 2012/10/24
- Antioxidant effects of the highly-substituted carbazole alkaloids and their related carbazoles Bioorganic and Medicinal Chemistry Letters 24巻 15号 3530-3533頁 2014/08/01
- Plasma Corticosterone Activates SGK1 and Induces Morphological Changes in Oligodendrocytes in Corpus Callosum Miyata, Shingo;Koyama, Yoshihisa;Takemoto, Kana;Yoshikawa, Keiko;Ishikawa, Toshiko;Taniguchi, Manabu;Inoue, Kiyoshi;Aoki, Miwa;Hori, Osamu;Katayama, Taiichi;Tohyama, Masaya PLOS ONE 6巻 5号 0-0頁 2011
- RAGE mediates vascular injury and inflammation after global cerebral ischemia Neurochemistry International 60巻 3号 220-228頁 2012/02/01
- The effect of Ndrg2 expression on astroglial activation Neurochemistry International 59巻 1号 21-27頁 2011/08/01
- The effects of dibenzoylmethane derivatives on the function of cultured astrocytes Takano, Katsura;Sugita, Kumiko;Moriyama, Mitsuaki;Hashida, Koji;Hibino, Satoshi;Choshi, Tominari;Murakami, Rika;Yamada, Masashi;Suzuki, Hiroto;Hori, Osamu;Nakamura, Yoichi JOURNAL OF PHARMACOLOGICAL SCIENCES 115巻 0号 187P-187P頁 2011
- Glutamate Preferentially Suppresses Osteoblastogenesis Than Adipogenesis Through the Cystine/Glutamate Antiporter in Mesenchymal Stem Cells Takarada-Iemata, Mika;Takarada, Takeshi;Nakamura, Yukari;Nakatani, Eri;Hori, Osamu;Yoneda, Yukio JOURNAL OF CELLULAR PHYSIOLOGY 226巻 3号 652-665頁 2011
講演・口頭発表等
その他(報告書など)
- A rat model of human FENIB (familial encephalopathy with neuroserpin inclusion bodies). 2006
- Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation. 16巻 1号 50-60頁 2007
- Hypoxia-mediated induction of heme oxygenase type I and carbon monoxide release from astrocytes protects nearby cerebral neurons from hypoxia-mediated apoptosis. 9, 543-552巻 2007
- Ischemia-induced neuronal cell death and stress response. 9巻 573-587頁 2007 ⑪講演資料等(セミナー,チュートリアル,講習,講義他)
- novel inhibitor of advanced glycation and endoplasmic reticulum stress reduces infarct volume in rat focal cerebral ischemia. 2007
- A Carbazole Derivative Protects Cells Against Endoplasmic Reticulum (ER) Stress and Glutathione Depletion. 108巻 2,164-71号 2008
芸術・フィールドワーク
特許
○オキシトシントランスポーター (公開年月:2016/06/23)
共同研究希望テーマ
科研費
○基盤研究(C)「小胞体内レドックス異常により誘導される神経細胞死とその制御」(2007-) 代表者
○特定領域研究「小胞体関連分解(ERAD)制御によるタンパク分解ストレスの軽減と細胞保護」(2008-) 代表者
○基盤研究(C)「ATF6による黒質神経細胞の救済と蛋白質凝集抑制」(2011-2013) 代表者
競争的資金・寄付金等
共同研究・受託研究実績
○パーキンソン病遺伝子ネットワーク解明と新規治療戦略(2007-2012)
A-STEP採択課題
学域・学類担当授業科目
○実践医学英語(2017)
○医学研究プレゼンテーション(2017)
○神経解剖学(2017)
○医学研究実践(2017)
○応用基礎配属(2017)
○最新医学研究(2017)
○英語コミュニケーション(2017)
○医薬保健学基礎(2017)
○発生学(2017)
○脳の構造(2016)
○医薬保健学基礎(2016)
○実践医学英語(2016)
○人体の発生(2016)
○最新医学研究(2016)
○医学研究プレゼンテーション(2016)
○医学研究実践(2016)
○応用基礎配属(2016)
○英語コミュニケーション(2016)
○プレゼン・ディベート論(初学者ゼミⅡ)(2016)
○初学者ゼミⅠ(2016)
○最新医学研究(2015)
○実践医学英語(2015)
○英語コミュニケーション(2015)
○医学研究実践(2015)
○最新医学研究(2015)
○応用基礎配属(2015)
○大学・社会生活論(2015)
○人体の発生(2015)
○脳の構造(2015)
○医薬保健学基礎(2015)
○大学・社会生活論(2014)
○初学者ゼミ(2014)
○人体の発生(2014)
○医薬保健学基礎(2014)
○脳の構造(2014)
大学院担当授業科目
○先端がん医科学セミナー(2017)
○先端医学セミナー(2017)
○プレゼンテーション方法論(2017)
○Up-to-dateセミナー(2017)
○神経分子標的学特論(2017)
○環境医科学Up-to-dateセミナー(2017)
○プレゼンテーション方法論(2017)
○先端医学セミナー(2017)
○神経分子標的学特論(2017)
○先端循環医科学セミナー(2017)
○循環医科学Up-to-dateセミナー(2017)
○先端環境医科学セミナー(2017)
○Up-to-dateセミナー(2017)
○先端脳医科学セミナー(2017)
○脳医科学Up-to-dateセミナー(2017)
○人体構造学(2017)
○神経分子標的学特論(2017)
○がん医科学Up-to-dateセミナー(2017)
○メディカルサイエンスセミナー(2016)
○先端脳医科学セミナー(2016)
○Up-to-dateセミナー(2016)
○神経分子標的学特論(2016)
○Up-to-dateセミナー(2016)
○人体構造学(2016)
○先端医学セミナー(2016)
○神経分子標的学特論(2016)
○先端環境医科学セミナー(2016)
○循環医科学Up-to-dateセミナー(2016)
○先端循環医科学セミナー(2016)
○環境医科学Up-to-dateセミナー(2016)
○先端がん医科学セミナー(2016)
○神経分子標的学特論(2016)
○プレゼンテーション方法論(2016)
○プレゼンテーション方法論(2016)
○先端医学セミナー(2016)
○脳医科学Up-to-dateセミナー(2016)
○がん医科学Up-to-dateセミナー(2016)
○神経分子標的学特論(2015)
○人体構造学(2015)
○人体構造学(2014)
○神経分子標的学特論(2014)
○基礎系教育セミナー(2014)