last modified：2025/03/22
Associate Professor OHTSUBO Koushiro
Faculty, Affiliation
University Hospital Kanazawa University Cancer Center
Clinical Professor
College and School Educational Field
Division of Medical Sciences, Graduate School of Medical Science
Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
Laboratory
Division of Medical Oncology, Cancer Research Institute, Kanazawa University TEL:076-265-2794 FAX:076-234-4524
Academic Background
【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor Graduate School, Division of Medicine 200103 Completed
【Academic background(Bachelor's Degree)】
Kanazawa University 199403
【Degree】
Doctor of Medicine
Career
Kanazawa University Cancer Center Clinical Professor(2016/08/01-)
Year & Month of Birth
1969/08
Academic Society
Award
Specialities
Gastroenterology
Speciality Keywords
Clinical Oncology Gastroenterology Gastroenterological Endoscopy
Research Themes
Endoscopic ultrasonographic evaluation of therapeutic intervention for non-alcoholic early chronic pancreatitis.
The concept of early chronic pancreatitis was initially described in the 2009 Japanese diagnostic criteria for chronic pancreatitis. However, the clinical features of non-alcoholic early chronic pancreatitis (NAECP) have not been defined. The aim of this study is to elucidate the clinical features of NAECP.
Thirteen patients, two men and 11 women were diagnosed with NAECP by revised 2009 criteria. Their clinical features, including their radiologic and endoscopic ultrasonographic (EUS) findings and clinical courses, were retrospectively reviewed.
Ten (77%) patients presented with back pain in addition to upper abdominal pain. Pancreatic enzymes were elevated in the sera of seven (54%) patients. EUS findings included lobularity with honeycombing in one (8%), lobularity without honeycombing in seven (54%), hyperechoic foci without shadowing in 10 (77%), strands in 13 (100%), and hyperechoic main pancreatic duct margin in 11 (85%). Neither contrast-enhanced computed tomography nor magnetic resonance imaging/ magnetic resonance cholangiopancreatography (MRCP) showed definite abnormalities in the pancreatic parenchyma. However, MRCP showed evidence of pancreaticobiliary maljunction and pancreatic divisum in one patient each. Camostat mesilate and high titer pancreatic enzyme pancrelipase were effective for relief of pain in all the patients except for two. However, the nine patients followed up for several years showed no improvement in endoscopic ultrasonographic findings.
EUS may be useful in diagnosing NAECP, even though CT and MRI could not detect abnormalities. Medication was effective for relief of pain, but did not improve endoscopic ultrasonographic findings for NAECP. Further investigations are necessary to identify methods to prevent NAECP progression.
Analysis of microRNA and methylation abnormality for early detection of pancreatic cancer
Analysis of epithelial mesenchymal transistion (EMT) markers of pancreatic cancer obtained by endoscopic ultrasound-guided fine needle aspiration (EUS-FNA)
Analysis of serial pancreatic juice aspiration cytological examination (SPACE) after endoscopic nasopancreatic drainage (ENPD) for early detection of pancreatic cancer
Analysis of pancreatic cancer treaed with FOLFIRINOX or GEM+nab-PTX
Evaluation of cell-free and concentrated ascites reinfusion therapy (CART) in the patients with peritonitis carcinomatosa
Analyses of complications after EUS-FNA
Analyses of adverse effect due to immunotherapy
EUS diagnosis of IPMN related pancreatic cancer
Thromboembolism complicated with pancreaic cancer
Efficacy and adverse effect of chemotherapy to pancreaic cancer
Books
Papers
- Pancreatic cancer associated with granulocyte-colony stimulating factor production confirmed by immunohistochemistry. JOURNAL OF CLINICAL GASTROENTEROLOGY 27 4 357-360 1998/04
- Mucin-producing biliary papillomatosis associated with gastrobiliary fistula. JOURNAL OF GASTROENTEROLOGY 34 1 141-144 1999/01
- Pneumatosis intestinalis and hepatic portal venous gas caused by mesenteric ischemia in the aged person. JOURNAL OF GASTROENTEROLOGY 36 3 338-340 2001/03
- Abnormalities of tumor suppressor gene p16 in pancreatic carcinoma: Immunohistochemical and genetic findings compared with clinicopathological parameters. JOURNAL OF GASTROENTEROLOGY 38 7 663-671 2003/07
- Preproenkephalin hypermethylation in the pure pancreatic juice compared with p53 mutation in the diagnosis of pancreatic carcinoma. Ohtsubo K, Watanabe H, Yao F, Okada G, Mouri H, Yamaguchi Y, et al. 41 8 791-7 2006/08
- A case of autoimmune pancreatitis associated with retroperitoneal fibrosis. Watanabe H, Tsuchiyama T, Mouri H, Yamaguchi Y, Motoo Y, et al. 8 3 320-5 2007/03
- A case of pancreatic cancer with formation of a mass mimicking alcoholic or autoimmune pancreatitis in a young man. Possibility of diagnosis by hypermethylation of pure pancreatic juice. Watanabe H, Okada G, Tsuchiyama T, Mouri H, Yamaguchi Y, et al. 9 1 37-45 2008/01
- Cancer of unknown primary site in which tumor marker-oriented chemotherapy was effective and pancreatic cancer was finally confirmed at autopsy. Ohtsubo K, Watanabe H, Yamada T, Tsuchiyama T, Mouri H, Yamashita K, et al. 48 18 1651-6 2009/09
- A case of advanced hepatocellular carcinoma treated effectively with irinotecan via hepatic arterial infusion followed by proton beam therapy. Ohtsubo K, Watanabe H, Tsuchiyama T, Mouri H, Yamaguchi Y, Motoo Y, et al. 15 5 316-21 2009/10
- The EGFR ligands amphiregulin and heparin-binding egf-like growth factor promote peritoneal carcinomatosis in CXCR4-expressing gastric cancer. 1) Yasumoto K, Yamada T, Kawashima A, Wang W, Li Q, Donev IS, Tacheuchi S, Mouri H, Yamashita K, Ohtsubo K, Yano S. Clin Cancer Res 17 11 3619-30 2011/07/01
- Endoscopic findings of upper gastrointestinal lesions in patients with pancreatic cancer. 13 4 420-6 2012/07
- Multiple factors influencing the release of hTERT mRNA from pancreatic cancer cell lines in in vitro culture. Okada G, Watanabe H, Ohtsubo K, Mouri H, Yamaguchi Y, Motoo Y, Sawabu N. Cell Biol Int. 36 6 545-53 2012/07/01
- [A case of poorly-differentiated neuroendocrine carcinoma of the ascending colon with multiple liver metastases successfully treated with cisplatin and irinotecan]. Yamashita, Kaname; Ishikawa, Daisuke; Nanjo, Shigeki; Takeuchi, Shinji; Yamada, Tadaaki; Mouri, Hisatsugu; Ohtsubo, Koushiro; Yasumoto, Kazuo; Kumagai, Masashi; Ueda, Yoshimichi; Yano, Seiji Gan to kagaku ryoho. Cancer & chemotherapy 39 9 1427-1430 2012/09
- Successful treatment of unresectable gallbladder cancer with low-dose paclitaxel as palliative chemotherapy after failure of gemcitabine and oral S-1: A case report. Tajima H, Ohta T, Shinbashi H, Hirose A, Tsukada T, Okamoto K, Nakanuma S, Sakai S, Furukawa H, Makino I, Nakamura K, Hayashi H, Oyama K, Inokuchi M, Nakagawara H, Miyashita T, Fujita H, Takamura H, Ninomiya I, Kitagawa H, Fushida S, Fujimura T, Mouri H, Ohtsubo K. Oncol Lett. 4 6 1281-4 2012/12/01
- Synchronous triple cancers of the pancreas, stomach, and cecum treated with S-1 followed by pancrelipase treatment of pancreatic exocrine insufficiency Ohtsubo K, Ishikawa D, Nanjo S, Takeuchi S, Yamada T, Mouri H, Yamashita K, Yasumoto K, Gabata T, Matsui O, Ikeda H, Takamatsu Y, Iwakami S, Yano S. Journal of the Pancreas 14 5 515-20 2013/09/01
- P53, hTERT, WT-1, and VEGFR2 are the most suitable targets for cancer vaccine therapy in HLA-A24 positive pancreatic adenocarcinoma. 2. Terashima T, Mizukoshi E, Arai K, Yamashita T, Yoshida M, Ota H, Onishi I, Kayahara M, Ohtsubo K, Kagaya T, Honda M, Kaneko S. Cancer Immunol Immunother 63 5 479-89 2014/05/01
- Expression of Akt kinase-interacting protein 1 (Aki1), a scaffold protein of the PI3K/PDK1/Akt pathway, in pancreatic cancer. Ohtsubo K, Yamada T, Zhao L, Jin T-F, Takeuchi S, Mouri H, Yamashita K, Yasumoto K, Fujita N, Kitagawa H, Ohta T, Ikeda H, Yano S. Pancreas 43 7 1093-100 2014/08/01
- Endoscopic ultrasonographic evaluation of therapeutic intervention for non-alcoholic early chronic pancreatitis. Ohtsubo K, Mouri H, Yamashita K, Toshima F, Inoue D, Gabata T, Watanabe H, Yano S. Journal of the Pancreas 17 6 629-36 2016/11/08
- Usefulness of endoscopic injection sclerotherapy using cyanoacrylate in four cases with solitary gastric varices Ohtsubo K, Watanabe H, Tsuchiyama T, Mouri H, Yamaguchi Y, Sawabu N. 23 1 19-24 2007/06
- Usefulness of endoscopic ultrasonography for the diagnoses of chronic pancreatitis Ohtsubo K, Okai T, Tsuchiyama T, Mouri H, Yamaguchi Y, Watanabe H, et al. 50 4 1093-8 2008/04
- Androgen replacement therapy for cancer-related symptoms in male advanced cancer patients: study protocol for a randomised prospective trial (ARTFORM study). Izumi K, Shigehara K, Nohara T, Narimoto K, Kadono Y, Nanjo S, Yamada T, Ohtsubo K, Yano S, Mizokami A. J Med Invest 64 202-4 2017
- A case of advanced pancreatic neuroendocrine tumor in which octreotide long-acting repeatable was effective after failure of everolimus and sunitinib. Kitade H, Ohtsubo K, Hokkoku K, Mori M, Osamura RY, Sakuma H, Nakai M, Yano S. International Cancer Conference Journal 2018
- Aberrant methylation of tumor suppressive miRNAs in bile from patients with pancreaticobiliary diseases. Ohtsubo K, Miyake K, Arai S, Fukuda K, Yanagimura N, Suzuki C, Otani S, Adachi Y, Tanimoto A, Nishiyama A, Yamashita K, Takeuchi S, Notohara K, Yoshimura K, Yano S. Anticancer Res 39 5449-59 2019
- Multiple Malignant Lymphomas of the Bile Duct Developing after Spontaneous Regression of an Autoimmune Pancreatitis-like Mass. Ohtsubo K, Yamashita K, Yanagimura N, Suzuki C, Tanimoto A, Nishiyama A, Takeuchi S, Iwaki N, Kawano M, Izumozaki A, Inoue D, Gabata T, Ikeda H, Watanabe M, Yano S. Intern Med 60 3 409-15 2021
- Clinical utility of circulating tumor DNA sequencing in advanced gastrointestinal cancer: SCRUM-Japan GI-SCREEN and GOZILA studies. Nakamura Y, Taniguchi H, Ikeda M, Bando H, Kato K, Morizane C, Esaki T, Komatsu Y, Kawamoto Y, Takahashi N, Ueno M, Kagawa Y, Nishina T, Kato T, Yamamoto Y, Furuse J, Denda T, Kawakami H, Oki E, Nakajima T, Nishida N, Yamaguchi K, Yasui H, Goto M, Matsuhashi N, Ohtsubo K, Yamazaki K, Tsuji A, Okamoto W, Tsuchihara K, Yamanaka T, Miki I, Sakamoto Y, Ichiki H, Hata M, Yamashita R, Ohtsu A, Odegaard JI, Yoshino T. Nat Med doi.org/10.1038/s41591-020-106 2020
- Androgen replacement therapy for cancer-related symptoms in male: result of prospective randomized trial (ARTFORM study). Izumi K, Iwamoto H, Yaegashi H, Nohara T, Shigehara K, Kadono Y, Nanjo S, Yamada T, Ohtsubo K, Yano S, Mizokami A. J Cachexia Sarcopenia Muscle 12 4 831-842 2021/04/01
- Adverse events of endoscopic ultrasound-guided fine-needle aspiration for histologic diagnosis in Japanese tertiary centers: Multicenter retrospective study. Kanno A, Yasuda I, Irisawa A, Hara K, Ashida R, Iwashita T, Takenaka M, Katanuma A, Takikawa T, Kubota K, Kato H, Nakai Y, Ryozawa S, Kitano M, Isayama H, Kamada H, Okabe Y, Hanada K, Ohtsubo K, Doi S, Hisai H, Shibukawa G, Imazu H, Masamune A. Dig Endosc 33 7 1146-1157 2021/07/01
- Circulating Tumor DNA Analysis Detects FGFR2 Amplification and Concurrent Genomic Alterations Associated with FGFR Inhibitor Efficacy in Advanced Gastric Cancer Jogo T, Nakamura Y, Shitara K, Bando H, Yasui H, Esaki T, Terazawa T, Satoh T, Shinozaki E, Nishina T, Sunakawa Y, Komatsu Y, Hara H, Oki E, Matsuhashi N, Ohta T, Kato T, Ohtsubo K, Kawakami T, Okano N, Yamamoto Y, Yamada T, Tsuji A, Odegaard JI, Taniguchi H, Doi T, Fujii S, Yoshino T. Clin Cancer Res 27 20 5619-5627 2021/10/01
- Carcinoma of unknown primary origin with isolated adrenal metastasis: a report of two cases. Kometani M, Yoneda T, Maeda Y, Ohtsubo K, Yamazaki Y, Ikeda H, Mori S, Aono D, Karashima S, Usukura M, Sasano H, Takeda Y. Endocr J 68 10 1209-1215 2021/10/01
- Risk factors for interstitial lung disease induced by gemcitabine plus albumin-bound paclitaxel therapy in pancreatic ductal adenocarcinoma patients. Ueda R, Yamamoto N, Hori Y, Yoshida K, Ohtsubo K, Terashima T, Shimada T, Sai Y. J Pharm Health Care Sci 8 1 5 2022/01/01
- Clinical Validity of Plasma-Based Genotyping for Microsatellite Instability Assessment in Advanced GI Cancers: SCRUM-Japan GOZILA Substudy. Nakamura Y, Okamoto W, Denda T, Nishina T, Komatsu Y, Yuki S, Yasui H, Esaki T, Sunakawa Y, Ueno M, Shinozaki E, Matsuhashi N, Ohta T, Kato K, Ohtsubo K, Bando H, Hara H, Satoh T, Yamazaki K, Yamamoto Y, Okano N, Terazawa T, Kato T, Oki E, Tsuji A, Horita Y, Hamamoto Y, Kawazoe A, Nakajima H, Nomura S, Mitani R, Yuasa M, Akagi K, Yoshino T. 6 e2100383 2022/02/01
- Methylation of Tumor Suppressive miRNAs in Plasma from Patients with Pancreaticobiliary Diseases. Ohtsubo K, Miyake K, Arai S, Fukuda K, Suzuki C, Kotani H, Tanimoto A, Nishiyama A, Nanjo S, Yamashita K, Takeuchi S, Yano S. Cancer Diag Prog 2022/04/01
- Long-Term Treatment Outcomes for Primary Mediastinal Germ Cell Tumors: What Is the Optimal Treatment Strategy to Maximize Outcomes for Non-seminomatous Germ Cell Tumors? Yaegashi H, Nohara T, Shigehara K, Izumi K, Kadono Y, Makino T, Yamashita K, Ohtsubo K, Ikeda H, Mizokami A. Cancer Diag Prog 2022/04/01
- Effects of Metastatic Sites on Circulating Tumor DNA in Patients With Metastatic Colorectal Cancer. Bando H, Nakamura Y, Taniguchi H, Shiozawa M, Yasui H, Esaki T, Kagawa Y, Denda T, Satoh T, Yamazaki K, Sunakawa Y, Kato T, Goto M, Yuki S, Nishina T, Oki E, Shinozaki E, Matsuhashi N, Takahashi N, Tsuji A, Ohtsubo K, Wakabayashi M, Ikeno T, Hata M, Odegaard JI, Yoshino T. JCO Precis Oncol 6 e2100535 2022
- NOTCH gene alterations in metastatic colorectal cancer in the Nationwide Cancer Genome Screening Project in Japan (SCRUM-Japan GI-SCREEN). Kajiwara T, Nishina T, Nakasya A, Yamashita N, Yamashita R, Nakamura Y, Shiozawa M, Yuki S, Taniguchi H, Hara H, Ohta T, Esaki T, Shinozaki E, Takashima A, Moriwaki T, Denda T, Ohtsubo K, Sunakawa Y, Horita Y, Kawakami H, Kato T, Satoh T, Ando K, Mizutani T, Yasui H, Goto M, Okuyama H, Yamazaki K, Yoshino T, Hyodo I. J Cancer Res Clin Oncol doi: 10.1007/s00432-022-04064- 2022
- Association of ERBB2 Copy Number and Gene Coalterations With Trastuzumab Efficacy and Resistance in Human Epidermal Growth Factor Receptor 2-Positive Esophagogastric and Gastric Cancer. Hino K, Nishina T, Kajiwara T, Bando H, Nakamura M, Kadowaki S, Minashi K, Yuki S, Ohta T, Hara H, Mizukami T, Moriwaki T, Ohtsubo K, Komoda M, Mitani S, Nagashima F, Kato K, Yamada T, Hasegawa H, Yamazaki K, Yoshino T, Hyodo I. JCO Precis Oncol 6 e2200135 2022
- Survival Outcomes of Patients With Primary Mediastinal Germ Cell Tumors: A Retrospective Single-institutional Experience Yaegashi H, Nohara T, Shigehara K, Izumi K, Kadono Y, Makino T, Yamashita K, Ohtsubo K, Ikeda H, Mizokami A. Cancer Diag Prog 2 3 352-359 2022/02/01
- Clinical significance of circulating-tumour DNA analysis by metastatic sites in pancreatic cancer. Umemoto K, Sunakawa Y, Ueno M, Furukawa M, Mizuno N, Sudo K, Kawamoto Y, Kajiwara T, Ohtsubo K, Okano N, Matsuhashi N, Itoh S, Matsumoto T, Shimizu S, Otsuru T, Hasegawa H, Okuyama H, Ohama H, Moriwaki T, Ohta T, Odegaard JI, Nakamura Y, Bando H, Yoshino T, Ikeda M, Morizane C. Br J Cancer 128 8 1603-1608 2023/04/01
- Mutational spectrum of TP53 gene correlates with nivolumab treatment efficacy in advanced gastric cancer (TP53MUT study). Ando K, Nakamura Y, Kitao H, Shimokawa M, Kotani D, Bando H, Nishina T, Yamada T, Yuki S, Narita Y, Hara H, Ohta T, Esaki T, Hamamoto Y, Kato K, Yamamoto Y, Minashi K, Ohtsubo K, Izawa N, Kawakami H, Kato T, Satoh T, Okano N, Tsuji A, Yamazaki K, Yoshino T, Maehara Y, Oki E. Br J Cancer 129 6 1032-1039 2023/10/01
- Clinical Validation of Plasma-Based Genotyping for RAS and BRAF V600E Mutation in Metastatic Colorectal Cancer: SCRUM-Japan GOZILA Substudy. Aoki Y, Nakamura Y, Denda T, Ohta T, Esaki T, Shiozawa M, Yamaguchi K, Yamazaki K, Sunakawa Y, Kato T, Okano N, Taniguchi H, Sato T, Oki E, Nishina T, Komatsu Y, Matsuhashi N, Goto M, Yasui H, Ohtsubo K, Moriwaki T, Takahashi N, Horita Y, Boku S, Wakabayashi M, Ikeno T, Mitani R, Yuasa M, Yoshino T. JCO Precis Oncol 7 e2200688 2023/06/01
- Efficacy of Targeted Trials and Signaling Pathway Landscape in Advanced Gastrointestinal Cancers From SCRUM-Japan GI-SCREEN: A Nationwide Genomic Profiling Program. Nakamura Y, Yamashita R, Okamoto W, Komatsu Y, Yuki S, Ueno M, Kato K, Taniguchi H, Kagawa Y, Denda T, Hara H, Esaki T, Moriwaki T, Sunakawa Y, Oki E, Nagashima F, Nishina T, Satoh T, Kawakami H, Yamaguchi K, Ohtsubo K, Kato T, Horita Y, Tsuji A, Yasui H, Goto M, Hamamoto Y, Wakabayashi M, Ikeno T, Shitara K, Bando H, Tsuchihara K, Miki I, Ichiki H, Ohtsu A, Yoshino T. JCO Precis Oncol 7 e2200653 2023/03/01
- Analysis of Methylation of Tumor-suppressive miRNAs and KRAS/TP53 Mutations in Pancreatic Juice. Ohtsubo K, Miyake K, Sato S, Sakaguchi H, Fukuda K, Kotani H, Nishiyama A, Nanjo S, Yamashita K, Takeuchi S, Yano S, Kuruma S, Nakahodo J, Kikuyama M, Taniguchi H. Anticancer Res 44 12 5253-5261 2024/12/01
- Different efficacy of tyrosine kinase inhibitors by KIT and PGFRA mutations identified in circulating tumor DNA for the treatment of refractory gastrointestinal stromal tumors. Hashimoto T, Nakamura Y, Komatsu Y, Yuki S, Takahashi N, Okano N, Hirano H, Ohtsubo K, Ohta T, Oki E, Nishina T, Yasui H, Kawakami H, Esaki T, Machida N, Doi A, Boku S, Kudo T, Yamamoto Y, Kanazawa A, Denda T, Goto M, Iida N, Ozaki H, Shibuki T, Imai M, Fujisawa T, Bando H, Naito Y, Yoshino T. BJC Rep 2 1 54 2024/07/25
- Targeted therapy guided by circulating tumor DNA analysis in advanced gastrointestinal tumors. Nakamura Y, Ozaki H, Ueno M, Komatsu Y, Yuki S, Esaki T, Taniguchi H, Sunakawa Y, Yamaguchi K, Kato K, Denda T, Nishina T, Takahashi N, Satoh T, Yasui H, Satake H, Oki E, Kato T, Ohta T, Matsuhashi N, Goto M, Okano N, Ohtsubo K, Yamazaki K, Yamashita R, Iida N, Yuasa M, Bando H, Yoshino T. Nat Med 31 1 165-175 2025/01/01
- Clinical utility of BRCA and ATM mutation status in circulating tumour DNA for treatment selection in advanced pancreatic cancer. Sudo K, Nakamura Y, Ueno M, Furukawa M, Mizuno N, Kawamoto Y, Okano N, Umemoto K, Asagi A, Ozaka M, Ohtsubo K, Shimizu S, Matsuhashi N, Itoh S, Matsumoto T, Satoh T, Okuyama H, Goto M, Hasegawa H, Yamamoto Y, Odegaard JI, Bando H, Yoshino T, Ikeda M, Morizane C. Br J Cancer 131 7 1237-1245 2024/10/01
Conference Presentations
- Analyses of aberrant methylation of tumor suppressive miRNAs in the patients with pancreaticobiliary diseases in bile juice(conference：Pancreas 2018)(2018/04/01)
- Analyses of Aberrant Methylation of Tumor Suppressive miRNAs in Bile in Patients With Pancreaticobiliary Diseases.(conference：The 50th Anniversary Joint Meeting of American Pancreatic Association and Jappanese Pancreas Society.)(2019/11/06)
- Application of Methylation of Tumor Suppressive miRNAs in Plasma from Patients with Pancreaticobiliary Diseases.(conference：IAP＆JPS 2022)(2022/07/01)
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「膵癌診断を目指した膵液中癌関連遺伝子のメチル化異常の検索」(2004-2005)
○「肺がんの転移と分子標的薬耐性を克服する統合的研究」(2012-2014)
○「膵癌における早期エピゲノム診断を目指したマイクロRNA発現異常領域の同定」(2017-2019)
○「膵癌高危険群における膵液中マイクロRNAとエピゲノム解析による早期診断法の確立」(2022-2024)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
Classes (Graduate Schools)
○Seminar on Clinical Oncology(2017)
○Seminar on Clinical Oncology(2016)