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Researcher Information

last modified：2024/11/22

Professor　HARADA Kenichi

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Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences　Department of Human Pathology

College and School Educational Field

Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Human Pathology　TEL:076-265-2195　FAX:076-234-4229

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University　Doctor　Graduate School, Division of Medicine　199603　Completed
【Academic background(Bachelor's Degree)】
Kanazawa University　199103

Career

(2014/05-)
(1997-2007)
Kanazawa University(2007/02-2014/04)

Year & Month of Birth

Academic Society




The Clinical Electron Microscopy Society of Japan











Award













Specialities

Human pathology、Experimental pathology、Immunology

Speciality Keywords

Immunology,Pathology,Liver

Research Themes

Pathology of the liver

I conduct basic analysis for pathological analysis and treatment strategies of hepatobiliary system diseases based on hepatic and biliary cell physiology and hepatic immunity analysis.

Immunology of the liver

Liver cancer

Books

  • 　原発性肝癌取扱い規約　第6版　補訂版　2019/03
  • 　Kenichi Harada　Biliary Diseases with Pancreatic Counterparts　NOVA　2017
  • 　Kenichi Harada　Pathology of the Bile Duct 　Springer　2017
  • 　Kenichi Harada, Yoshifumi Ubara　IgG4-Related　Kidney Diseases 　Springer　2016
  • 　Kenichi Harada　The Liver in Systemic Diseases　　（Hiromasa Ohira　Editor） 　　Chapter 15 　　　IgG4-Related　Diseases and the liver 　Springer　2016

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  • 　Harada K,　Nakanuma Y　IgG4-Related Disease Sclerosing Cholangitis 　Springer Japan　2014
  • 　Mechanisms of the Sclerosing Cholangiopathy in Biliary Atresia: Association with Biliary Innate Immunity and Epithelial-Mesenchymal Transition　Kodansha Shuppan Service Center　2009/11

Papers

  • 　Biliary Innate Immunity in the Pathogenesis of Biliary Diseases 　１　９　83-90
  • 　Biliary Innate Immunity:Function and Modulation　Nakanuma Y　Volume 2010, Article
  • 　Cell-kinetic study of proliferating bile ductules in various hepatobiliary diseases　LIVER　18　4　277-284　1998/04
  • 　Distribution of apoptotic cells and expression of apoptosis-related proteins along the intrahepatic biliary tree in normal and non-biliary diseased liver　HISTOPATHOLOGY　37　4　347-354　2000/04
  • 　Enhanced apoptosis relates to bile duct loss in primary biliary cirrhosis　HEPATOLOGY　26　6　1399-1405　1997/12

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  • 　Enhanced expression of basement-membrane-type heparan sulfate proteoglycan in tumor fibromyxoid stroma of intrahepatic cholangiocarcinoma　Pathol Int　51　4　248-256　2001/04
  • 　Epithelioid cell granulomas in chronic hepatitis C: Immunohistochemical character and histological marker of favourable response to interferon alpha therapy　HISTOPATHOLOGY　33　3　216-221　1998/03
  • 　Frequent molecular identification of Campylobacter but not Helicobacter genus in bile and biliary epithelium in hepatholithiasis　J Pathol　193　2　218-223　2001/02
  • 　Human Reg l is up-regulated in intrahepatic cholangiocarcinoma and its precursor lesions　HEPATOLOGY　33　5　1036-1042　2001/05
  • 　In situ nucleic acid detection of PDC-E2, BCOADC-E2 OGDC-E-2, PDC-E l alpha, BCOADC-E l alpha, and the E3 binding protein (Protein X) in primary biliary cirrhosis　HEPATOLOGY　30　1　36-45　1999/01
  • 　In situ nucleic acid hybridization of cytokines in primary biliary cirrhosis: predominance of the Th1 subset　HEPATOLOGY　25　4　791-796　1997/04
  • 　In situ nucleic acid hybridization of pyruvate dehydrogenase complex-E2 in primary biliary cirrhosis: pyruvate dehydrogenase complex-E2 messenger RNA is expressed in hepatocytes but not in biliary epithelium　HEPATOLOGY　25　1　27-32　1997/01
  • 　Increased expression of WAF1 in intrahepatic bile ducts in primary biliary cirrhosis relates to apoptosis　J Hepatol　34　4　500-506　2001/04
  • 　Molecular identification of bacterial 16S ribosomal RNA gene in liver tissue of primary biliary cirrhosis: Is Propionibacterium acnes involved in granuloma formation ?　HEPATOLOGY　33　3　530-536　2001/03
  • 　PCR and in situ hybridization studies of telomerase subunits in human non-neoplsatic livers　J Pathol　193　2　210-217　2001/02
  • 　Significance of CD30-positive lymphocytes in primary biliary cirrhosis　J Gastroenterol Hepatol　14　12　1197-1202　1997/12
  • 　Accumulating CD57 + CD3 + natural killer T cells are related to intrahepatic bile duct lesions in primary biliary cirrhosis.　LIVER　23　2　94-100　2003/04
  • 　Osteopontin is involved in the formation of epithelioid granuloma and bile duct injury in primary biliary cirrhosis.　PATHOLOGY INTERNATIONAL　35　1　8-17　2003/01
  • 　Lipopolysaccharide activates nuclear factor-kappaB through toll-like receptors and related molecules in cultured biliary epithelial cells.　LABORATORY INVESTIGATION　83　11　1657-1667　2003/11
  • 　Reduced expression of syndecan-1 correlates with histologic dedifferentiation, lymph node metastasis, and poor prognosis in intrahepatic cholangiocarcinoma.　HUMAN PATHOLOGY　34　9　857-863　2003/09
  • 　Type1 and type2 memory T cells imbalance shown by expression of intrahepatic chemokine receptors relates to pathogenesis of primary biliary cirrhosis.　24　3　290-299　2002/11
  • 　Th1 cytokine-induced downregulation of PPARgamma in human biliary cells relates to cholangitis in primary biliary cirrhosis.　HEPATOLOGY　41　6　1329-1338　2005/06
  • 　Peptide Antibiotic Human Beta-Defensin-1 and -2 Constitute Antimicrobial Defense in the Intrahepatic Biliary Tree　HEPATOLOGY　40　4　925-932　2004/10
  • 　Innate immune response to double-stranded RNA in biliary epithelial cells is associated with the pathogenesis of biliary atresia.　HEPATOLOGY　27;46(4)　1146-1154　2007/07
  • 　Induction of innate immune response and absence of subsequent tolerance to dsRNA in biliary epithelial cells relate to the pathogenesis of biliary atresia.　Liver Int　28(5)　614-21　2008/05
  • 　Epithelial-mesenchymal transition induced by biliary innate immunity contributes to the sclerosing cholangiopathy of biliary atresia.　J Pathol.　217(5)　654-64　2009
  • 　Periductal interleukin-17 production in association with biliary innate immunity contributes to the pathogenesis of cholangiopathy in primary biliary cirrhosis.　Clin Exp Immunol.　157(2):261-70　2009/08
  • 　Successful second conversion surgery after trastuzumab deruxtecan for recurrent HER2-positive gastric cancer.　Takeshi Terashima,Tatsuya Yamashita,Hisashi Takabatake,Shinichi Nakanuma,Jun Kinoshita,Shintaro Yagi,Eishiro Mizukoshi,Kenichi Harada,Sachio Fushida,Shuichi Kaneko　Clinical journal of gastroenterology　2023/01/28
  • 　Reactive lymphoid hyperplasia of the liver: A case report featuring characteristic nodular and perinodular enhancement.　Hirohito Osanai,Kazuto Kozaka,Norihide Yoneda,Kotaro Yoshida,Azusa Kitao,Toshifumi Gabata,Kenichi Harada,Isamu Makino,Satoshi Kobayashi　Radiology case reports　19　5　1998　2024/05
  • 　Dynamic CT and Gadoxetic Acid-enhanced MRI Characteristics of P53-mutated Hepatocellular Carcinoma.　Azusa Kitao,Osamu Matsui,Yu Zhang,Takahiro Ogi,Satoko Nakada,Yasunori Sato,Kenichi Harada,Norihide Yoneda,Kazuto Kozaka,Dai Inoue,Kotaro Yoshida,Wataru Koda,Taro Yamashita,Tatsuya Yamashita,Shuichi Kaneko,Satoshi Kobayashi,Toshifumi Gabata　Radiology　220531　2022/10/11
  • 　Anti-inflammatory and antifibrotic effects of CBP/β-catenin inhibitor for hepatocytes: small molecular inhibitor, OP-724 possibly improves liver function　Hirofumi Ouchi,Yuki Mizutani,Kaori Yoshimura,Yasunori Sato,Kiminori Kimura,Yushi Haruyama,Kenichi Harada　Medical Molecular Morphology　56　2　94　2023/01/16　
  • 　Comparison of Tofogliflozin and Glimepiride Effects on Nonalcoholic Fatty Liver Disease in Participants With Type 2 Diabetes: A Randomized, 48-Week, Open-Label, Active-Controlled Trial.　Yumie Takeshita,Masao Honda,Kenichi Harada,Yuki Kita,Noboru Takata,Hiromasa Tsujiguchi,Takeo Tanaka,Hisanori Goto,Yujiro Nakano,Noriho Iida,Kuniaki Arai,Tatsuya Yamashita,Eishiro Mizukoshi,Hiroyuki Nakamura,Shuichi Kaneko,Toshinari Takamura　Diabetes care　45　9　2064　2022/09/01
  • 　Clinical trial of autologous adipose tissue-derived regenerative (stem) cells therapy for exploration of its safety and efficacy.　Yoshio Sakai,Shinya Fukunishi,Masayuki Takamura,Kazunori Kawaguchi,Oto Inoue,Soichiro Usui,Shinichiro Takashima,Akihiro Seki,Akira Asai,Yusuke Tsuchimoto,Alessandro Nasti,Tuyen Thuy Bich Ho,Yasuhito Imai,Kenichi Yoshimura,Toshinori Murayama,Taro Yamashita,Kuniaki Arai,Tatsuya Yamashita,Eishiro Mizukoshi,Masao Honda,Takashi Wada,Kenichi Harada,Kazuhide Higuchi,Shuichi Kaneko　Regenerative therapy　18　97　2021/12
  • 　Inhibition of CBP/β-catenin signaling ameliorated fibrosis in cholestatic liver disease.　Masamichi Kimura,Koji Nishikawa,Yosuke Osawa,Jun Imamura,Kenzaburo Yamaji,Kenichi Harada,Hiroshi Yatsuhashi,Kazumoto Murata,Kouichi Miura,Atsushi Tanaka,Tatsuya Kanto,Michinori Kohara,Terumi Kamisawa,Kiminori Kimura　Hepatology communications　6　10　2732　2022/10
  • 　A novel pathologic marker, indoleamine 2,3-dioxygenase 1, for the cholangiopathy of immune checkpoint inhibitors-induced immune mediated hepatotoxicity as adverse events and the prediction of additional ursodeoxycholic acid treatment　Kaori Yoshimura,Yuko Tamano,Hiep Nguyen Canh,Li Zihan,Dong Le Thanh,Yasunori Sato,Takeshi Terashima,Shinji Shimoda,Kenichi Harada　Medical Molecular Morphology　56　2　106　2023/01/04　
  • 　Clinical practice guidelines for autoimmune hepatitis.　Hiromasa Ohira,Atsushi Takahashi,Mikio Zeniya,Masanori Abe,Teruko Arinaga-Hino,Satoru Joshita,Akinobu Takaki,Nobuhiro Nakamoto,Jong-Hon Kang,Yoshiyuki Suzuki,Tsuyosi Sogo,Ayano Inui,Kazuhiko Koike,Kenichi Harada,Yasunari Nakamoto,Yasuteru Kondo,Takuya Genda,Koichi Tsuneyama,Tsuyoshi Matsui,Atsushi Tanaka　Hepatology research : the official journal of the Japan Society of Hepatology　52　7　571　2022/07
  • 　Non-occlusive mesenteric ischemia during bevacizumab treatment for glioblastoma: a case report.　Nozomu Oikawa,Masashi Kinoshita,Minako Yamamura,Takehiro Uno,Toshiya Ichinose,Hemragul Sabit,Tomoyuki Hayashi,Dai Inoue,Kenichi Harada,Mitsutoshi Nakada　Acta neurochirurgica　164　10　2767　2022/07/30
  • 　Safety, tolerability, and anti-fibrotic efficacy of the CBP/β-catenin inhibitor PRI-724 in patients with hepatitis C and B virus-induced liver cirrhosis: An investigator-initiated, open-label, non-randomised, multicentre, phase 1/2a study　Kiminori Kimura,Tatsuya Kanto,Shinji Shimoda,Kenichi Harada,Masamichi Kimura,Koji Nishikawa,Jun Imamura,Eiichi Ogawa,Masanao Saio,Yoshihiro Ikura,Takuji Okusaka,Kazuaki Inoue,Tetsuya Ishikawa,Ichiro Ieiri,Junji Kishimoto,Koji Todaka,Terumi Kamisawa　eBioMedicine　80　104069　2022/06
  • 　A case of focal nodular hyperplasia-like lesion presenting unusual signal intensity on the hepatobiliary phase of gadoxetic acid-enhanced magnetic resonance image.　Kumi Ozaki,Norihide Yoneda,Kenichi Harada,Hiroshi Ikeno,Misa Takahashi,Yasuharu Kaizaki,Kazuya Maeda,Shohei Higuchi,Kenji Takata,Toshifumi Gabata　Radiology case reports　18　9　3093　2023/09
  • 　A case of hepatic small vessel neoplasm without previously reported hotspot mutation of alpha subfamily of G proteins.　Minako Yamamura,Yasunori Sato,Kenta Takahashi,Hiep Nguyen Canh,Zihan Li,Kazuyoshi Hosomichi,Atsushi Tajima,Takuro Terada,Yasuni Nakanuma,Kenichi Harada　Human Pathology Reports　29　300660　2022/09
  • 　The disturbance of the distribution of T helper cell subsets in the mantle area surrounding germinal centers in immunoglobulin G4-related sclerosing sialadenitis.　Satomi Kasashima,Atsuhiro Kawashima,Nozomu Kurose,Satoru Ozaki,Hiroko Ikeda,Kenichi Harada　Virchows Archiv : an international journal of pathology　2022/07/28
  • 　The Challenges of Primary Biliary Cholangitis: What is new and what needs to be done　Benedetta Terziroli Beretta-Piccoli,Kenichi Harada,et al.　J Autoimmunity　105　102328　2019
  • 　A Long-term Survival after Surgical Treatment for Atypical Aortic Coarctation Complicating Takayasu Arteritis with Inactive Disease at the Diagnosis: An Appropriately Treated Autopsy Case.　Yoshida M, Zoshima T, Hara S, Mizushima I, Fujii H, Yamada K, Sato Y, Harada K, Kawano M.　Intern Med.　58　15　2241-2246　2019
  • 　A case of IgG4-related tubulointerstitial nephritis and membranous glomerulonephritis during the clinical course of gastric cancer: Imaging features of IgG4-related kidney disease.　Horita S, Fujii H, Mizushima I, Fujisawa Y, Hara S, Yamada K, Inoue D, Nakajima K, Harada K, Kawano M.　Mod Rheumatol. 　29　3　542-546　2019
  • 　Expression of fatty‑acid‑binding protein 5 in intrahepatic and extrahepatic cholangiocarcinoma: the possibility of different energy metabolisms in anatomical location　Risa Nakagawa, Nguyen Canh Hiep, Hirofumi Ouchi, Yasunori Sato, Kenichi Harada.　Medical Molecular Morphology　2019　
  • 　Expression of endoplasmic reticulum oxidoreductase 1-α in cholangiocarcinoma tissues　and its effects on the proliferation and migration of cholangiocarcinoma cells　Wendi Yan, Xue Wang,1, Tesi Liu, Liyan Chen, Longzhe Han, Jing Xu, Guihua Jin, Kenichi Harada, Zhenhua Lin, Xiangshan Ren　Cancer Management and Research 　11　6727–6739　2019
  • 　A case of primary biliary cholangitis overlapping with type 2 autoimmune hepatitis　Nozomi Amano, Sho Sato, Ayato Murata, Hironori Tsuzura, Ko Tomishima, Shunsuke Sato, Kohei Matsumoto, Yuji Shimada, Katsuyori Iijima, Kenichi Harada, Takuya Genda.　Clinical Journal of Gastroenterology　2019　
  • 　Case of metastatic glioblastoma with primitive neuronal component to the lung　Sho Tamai, Masashi Kinoshita, Hemragul Sabit, Takuya Furuta, Katsuyoshi Miyashita,Kaori Yoshimura, Taku Homma, Kenichi Harada and Mitsutoshi Nakada　Neuropathology　39　218–223　2019
  • 　Serum C16:1n7/C16:0 ratio as a diagnostic marker for nonalcoholic steatohepatitis　Kazutoshi Yamada,Kenichi Harada,et al.　Journal of Gastroenterology and Hepatology　2019
  • 　A case of chronic pancreatitis exacerbation associated with pancreatic arteriovenous malformation: a case report and literature review.　Seike T, Harada K, et al.　Clinical journal of gastroenterology　12　2　135-141　2019
  • 　糖尿病の若年女性に生じた炎症性肝細胞腺腫の1例　64　183-189　2019/02
  • 　Unclassified hepatocellular adenoma in a middle-aged woman with glucose intolerance.　Ozaki K, Harada K, Yamamoto T, Aoyagi H, Kaizaki Y, Yoshikawa J. 　Clin J Gastroenterol. 　2017
  • 　Usefulness of laparoscopy and intraductal ultrasonography in a patient with isolated immunoglobulin G4-related sclerosing cholangitis. 　Ohno Y, Kumagi T, Imamura Y, Kuroda T, Koizumi M, Watanabe T, Yoshida O, Tokumoto Y, Takeshita E, Abe M, Harada K, Hiasa Y. 　Clin J Gastroenterol. 　2017
  • 　Role for Neutrophil Extracellular Traps (NETs) and Platelet Aggregation in Early Sepsis-induced Hepatic Dysfunction. 　Sakurai K, Miyashita T, Okazaki M, Yamaguchi T, Ohbatake Y, Nakanuma S, Okamoto K,Sakai S, Kinoshita J, Makino I, Nakamura K, Hayashi H, Oyama K, Tajima H, Takamura H, Ninomiya I, Fushida S, Harada K, Harmon JW, Ohta T.　In Vivo. 　31　6　1051-1058.　2017
  • 　BRAF V600E, TERT promoter mutations and CDKN2A/B homozygous deletions are frequent in epithelioid glioblastomas: A histological and molecular analysis focusing on intratumoral heterogeneity. 　Nakajima N, Nobusawa S, Nakata S, Nakada M, Yamazaki T, Matsumura N, Harada K, Matsuda H, Funata N, Nagai S, Nakamura H, Sasaki A, Akimoto J, Hirato J, Yokoo H. 　Brain Pathol. 　2017
  • 　Clinicopathological Study of Autoimmune Hepatitis Cases That Were Difficult to Differentiate from Drug-Induced Liver Injury.　Tsutsui A, Harada K, Tsuneyama K, Senoh T, Nagano T, Takaguchi K, Ando M, Nakamura S, Mizobuchi K, Kudo M.　Dig Dis.　35　6　506-514.　2017
  • 　Sclerosing and obstructive cholangiopathy in biliary atresia: mechanisms and association with biliary innate immunity　Kenichi Harada　Pediatr Surg Int　2017
  • 　Clinical features of cystatin A expression in patients with pancreatic ductal adenocarcinoma.　Komura T, Takabatake H, Harada K, Yamato M, Miyazawa M, Yoshida K, Honda M, Wada T, Kitagawa H, Ohta T, Kaneko S, Sakai Y.　Cancer Sci.　2017
  • 　A case of ruptured hepatocellular carcinoma (HCC) in resolving non-alcoholic steatohepatitis associated with type 2 diabetes: Is early detection of diabetes-related HCC feasible?　Ikura Y, Tiniakos DG, Tanaka T, Harada K.　J Diabetes.　9　3　311-313.　2017
  • 　Gadoxetic acid-enhanced magnetic resonance imaging reflects co-activation of β-catenin and hepatocyte nuclear factor 4α in hepatocellular carcinoma.　Kitao A, Matsui O, Yoneda N, Kozaka K, Kobayashi S, Koda W, Minami T, Inoue D, Yoshida K, Yamashita T, Yamashita T, Kaneko S, Takamura H, Ohta T, Ikeda H, Sato Y, Nakanuma Y, Harada K, Kita R, Gabata T. 　Hepatol Res.　2017
  • 　Diagnostic sensitivity of cutoff values of IgG4-positive plasma cell number and IgG4-positive/CD138-positive cell ratio in typical multiple lesions of patients with IgG4-related disease.　Mizushima I, Yamada K, Harada K, Matsui S, Saeki T, Kondo S, Takahira M, Waseda Y, Hamaguchi Y, Fujii H, Yamagishi M, Kawano M.　Mod Rheumatol.　22　1-7　2017
  • 　Challenges and difficulties in pathological diagnosis of autoimmune hepatitis.　Harada K, Hiep NC, Ohira H.　Hepatol Res. 　47　10　963-971　2017
  • 　Safety, Tolerability, and Preliminary Efficacy of the Anti-Fibrotic Small Molecule PRI-724, a CBP/β-Catenin Inhibitor, in Patients with Hepatitis C Virus-related Cirrhosis: A Single-Center, Open-Label, Dose Escalation Phase 1 Trial　Kimura K, Ikoma A, Shibakawa M, Shimoda S, Harada K, Saio M, Imamura J, Osawa Y, Kimura M, Nishikawa K, Okusaka T, Morita S, Inoue K, Kanto T, Todaka K, Nakanishi Y, Kohara M, Mizokami M.　E Bio Medicine　2017
  • 　The simultaneous inhibition of the mTOR and MAPK pathways with Gnetin-C induces apoptosis in acute myeloid leukemia　Espinoza JL, Elbadry MI , Taniwaki M , Harada K ,Trung LQ , Nakagawa N , Takami A , Ishiyama K ,Yamauchi T, Takenaka K , Nakao S.　Cancer Letters　400　127-136　2017
  • 　Acute presentation of autoimmune hepatitis: a multicentre study with detailed histological evaluation in a large cohort of patients.　Hiep NC, Harada K, Ouchi H, Sato Y,Tsuneyama , Kage M, Nakano M, Yoshizawa K, Takahashi A, Abe , Kang JH, Koike K, Inui A, Fujisawa T, Takaki A, Arinaga-Hino T, Torimura T, Suzuki Y, Fujiwara K, Zeniya Ohira H, Tanaka A, Takikawa H; Intractable Liver and Biliary Diseases Study Group of Japan.　J Clin Pathol.　2017
  • 　Rathke Cleft Cyst with Entirely Ossified Cyst Wall and Partially Solid Cyst Content: A Case Report and Literature Review　Hayashi Y, Oishi M, Fukui I, Sasagawa Y, Harada K, Nakada M.　World Neurosurg. 　2017 Feb;98:882.e15-882.e20. 　2017
  • 　The PD-1/PD-L1 axis may be aberrantly activated in occupational cholangiocarcinoma　Sato Y, Masahiko Kinoshita M, Takemura S, Tanaka S, Hamano G, Nakamori S, Fujikawa M, Sugawara Y, Yamamoto T, Arimoto A, Yamamura M, Sasaki M, Harada K, Nakanuma Y and Kubo S. 　Pathol Int.　67　3　163-170　2017
  • 　Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal paucity of alterations in TP53 and SMAD4.　Hosoda W, Chianchiano P, Griffin JF, Pittman ME, Brosens LA, Noë M, Yu J, Shindo K, Suenaga M, Rezaee N, Yonescu R, Ning Y, Albores-Saavedra J, Yoshizawa N, Harada K, Yoshizawa A, Hanada K, Yonehara S, Shimizu M, Uehara T, Samra JS, Gill AJ, Wolfgang CL, Goggins MG, Hruban RH, Wood LD.　J Pathol.　242　1　16-23　2017
  • 　Expression and localization of sterile alpha motif domain containing 5 is associated with cell type and malignancy of biliary tree.　Yagai T, Matsui S, Harada K, Inagaki F, Saijou E, Miura Y, Nakanuma Y, Miyajima A, Tanaka M. 　PLoS One.　12　4　e0175355.　2017
  • 　Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for primary biliary cholangitis in the Japanese population.　Kawashima M, Hitomi Y, Aiba Y, Nishida N, Kojima K, Kawai Y, Nakamura H, Tanaka A,Zeniya M, Hashimoto E, Ohira H, Yamamoto K, Abe M, Nakao K, Yamagiwa S, Kaneko S, Honda M, Umemura T, Ichida T, Seike M, Sakisaka S, Harada M, Yokosuka O, Ueno Y, Senju M, Kanda T, Shibata H, Himoto T, Murata K, Miyake Y, Ebinuma H, Taniai M, Joshita S, Nikami T, Ota H, Kouno H, Kouno H, Nakamuta M, Fukushima N, Kohjima M,Komatsu T, Komeda T, Ohara Y, Muro T, Yamashita T, Yoshizawa K, Nakamura Y, Shimada M, Hirashima N, Sugi K, Ario K, Takesaki E, Naganuma A, Mano H, Yamashita H, Matsushita K, Yamauchi K, Makita F, Nishimura H, Furuta K, Takahashi N, Kikuchi M, Masaki N, Tanaka T, Tamura S, Mori A, Yagi S, Shirabe K, Komori A, Migita K, Ito M, Nagaoka S, Abiru S, Yatsuhashi H, Yasunami M, Shimoda S, Harada K, Egawa H, Maehara Y, Uemoto S, Kokudo N, Takikawa H, Ishibashi H, Chayama K, Mizokami M, Nagasaki M, Tokunaga K, Nakamura M. 　Hum Mol Genet.　26　3　650-659　2017
  • 　Pathological findings of nonalcoholic steatohepatitis and nonalcoholic fatty liver disease.　Sakamoto M, Tsujikawa H, Effendi K, Ojima H, Harada K, Zen Y, Kondo F, Nakano M, Kage M, Sumida Y, Hashimoto E, Yamada G, Okanoue T, Koike K. 　Pathol Int.　67　1　1-7　2017
  • 　正常肝に発生した細胆管細胞癌の１例　49　10　1006-1015　2016
  • 　Adult bile duct strictures: differentiating benign biliary stenosis from cholangiocarcinoma　Nguyen Canh Hiep,　Kenichi Harada.　Medical Molecular Morphology　2016
  • 　Hepatocyte nuclear factor 1α-inactivated hepatocellular adenomas exhibit high 18F-fludeoxyglucose uptake associated with glucose-6-phosphate transporter inactivation　Kumi Ozaki, Kenichi Harada, Noboru Terayama, Osamu Matsui, Satoshi Saitoh, Yoshito Tomimaru, Takeshi fujii, Toshifumi Gabata.　Br J Radiol　2016
  • 　Characterization of intraductal papillary neoplasm of bile duct with respect to histopathologic similarities to pancreatic intraductal papillary mucinous neoplasm.　Nakanuma Y, Kakuda Y, Uesaka K, Miyata T, Yamamoto Y, Fukumura Y, Sato Y, Sasaki M, Harada K, Takase M.　Hum Pathol.　51　103-13　2016
  • 　Application and Validation of a New Histologic Staging and Grading System for Primary Biliary Cirrhosis.　Harada K, Hsu M, Ikeda H, Zeniya M, Nakanuma Y.　J Clin Gastroenterol　47　2　174-81　2013
  • 　Participation of natural killer cells in the pathogenesis of bile duct lesions in biliary atresia　Okamura, Atsushi; Harada, Kenichi; Nio, Masaki; Nakanuma, Yasuni　Journal of Clinical Pathology　66　2　99-108　2013　
  • 　Tissue culture correlational study of genetic cholangiopathy of autosomal recessive polycystic kidney disease　Nakanuma, Yasuni; Sato, Yasunori; Harada, Kenichi　Methods in Molecular Biology　945　303-318　2013　
  • 　Clinicopathological significance of S100 protein expression in cholangiocarcinoma　Sato, Yasunori; Harada, Kenichi; Sasaki, Motoko; Nakanuma, Yasuni　Journal of Gastroenterology and Hepatology (Australia)　28　8　1422-1429　2013　
  • 　Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis.　Harada K, Kakuda Y, Sato Y, Ikeda H, Shimoda S, Yamamoto Y, Inoue H, Ohta H, 　J Clin Pathol　2013
  • 　Clinicopathological significance of serum fractalkine in primary biliary cirrhosis.　Harada K, Kakuda Y, Nakamura M, Shimoda S, Nakanuma Y.　Dig Dis Sci　58　10　3037-43　2013
  • 　Histological characteristics of biliary intraepithelial neoplasia-3 and intraepithelial spread of cholangiocarcinoma.　Sato Y, Harada K, Sasaki M, Nakanuma Y. 　Virchows Arch　462　4　421-7　2013
  • 　Biliary adenofibroma with ominous features of imminent malignant changes　 Akemi Tsutsui, Yoshimi Bando, Yasunori Sato, Hidenori Miyake, Seiko Sawada-Kitamura, 　Clin J Gastroenterol. 　2014
  • 　What Are the Precursor and Early Lesions of Peripheral Intrahepatic Cholangiocarcinoma?　Yasuni Nakanuma, Akemi Tsutsui, Xiang Shan Ren, Kenichi Harada, 　International Journal of Hepatology.　2014
  • 　Extrahepatic Malignancies in Primary Biliary Cirrhosis: A Comparative Study at Two Europian Centers. 　Floreani A, Spinazze A, Caballeria L, Reig A, Cazzagon N, Franceschet I, Buja A, Furlan P,　Clin Rev Allergy Immunol. 　2014
  • 　Histological characterization of biliary intraepithelial neoplasia with respect to pancreatic intraepithelial neoplasia.　Yasunori Sato, Kenichi Harada, Motoko Sasaki, Yasuni Nakanuma.　International Journal of Hepatology.　2014
  • 　Systemic and local expression levels of TNF-like ligand 1A and its decoy receptor 3 are increased in primary biliary cirrhosis　Yoshihiro Aiba, Kenichi Harada, Atsumasa Komori, Masahiro Ito, Shinji Shimoda, 　Liver International　34　679-688　2014
  • 　Different carcinogenic process in cholangiocarcinoma cases epidemically developing among workers of a printing company in Japan　Yasunori Sato, Shoji Kubo, Shigekazu Takemura, Yasuhiko Sugawara, Shogo Tanaka,　Int J Clin Exp Pathol.　7　8　4745-4754　2014
  • 　Clinical course after corticosteroid therapy in IgG4-related aortitis/periaortitis and periarteritis: a retrospective multicenter study 　Ichiro Mizushima, Dai Inoue, Motohisa Yamamoto, Kazunori Yamada, Takako Saeki,　Arthritis Research & Therapy 　16　4　R156　2014
  • 　Cholangiocarcinoma with respect to IgG4 Reaction : Review Article　Kenichi Harada, Yasuni Nakanuma.　International Journal of Hepatology　2014
  • 　Significance of oestrogen-related receptor　γon biliary epithelial cells in the pathogenesis of primary biliary cirrhosis.　Kenichi Harada, Kakuda Yuko, Yasunori Sato, Hiroko ikeda, Yasuni Nakanuma.　J Clin Pathol.　67　566-572　2014
  • 　Clinicopathological study of primary biliary cirrhosis with interface hepatitis compared to autoimmune hepatitis.　Mio Kobayashi, Yuko Kakuda, Kenichi Harada, Yasunori Sato, Motoko Sasaki, 　World J Gastroenterol. 　20　13　3597-3608　2014
  • 　A condition closely mimicking IgG4-related disease despite the absence of serum IgG4 elevation and IgG4-positive plasma cell infiltration.　Satoshi Hara, Mitsuhiro Kawano, Ichiro mizushima, Kazunori Yamada, Kentaro Fujita, 　MODERN RHEUMATOLOGY. 　2　1-6　2014
  • 　Prevalence and risk factors of hepatocellular carcinoma in Japanese patients with primary biliary cirrhosis.　Harada K, Nakanuma Y. 　Hepatol Res 　44　2　133-40　2014
  • 　Activation of the PI3K/mTOR Pathway Is Involved in Cystic Proliferation of Cholangiocytes of the PCK Rat.　Ren XS, Sato Y, Harada K, Sasaki M, Furubo S, Song JY, Nakanuma Y.　PLoS One　30　9(1)　e87660.　2014
  • 　Cystic and micropapillary epithelial changes of peribiliary glands might represent a precursor lesion of biliary epithelial neoplasms.　Sato Y, Harada K, Sasaki M, Nakanuma Y.　Virchows Arch.　464　2　157-63　2014
  • 　Guidelines for the management of primary biliary cirrhosis: The Intractable Hepatobiliary Disease Study Group supported by the Ministry of Health, Labour and Welfare of Japan.　 Working Subgroup (English version) for Clinical Practice Guidelines for Primary Biliary 　Hepatol Res.　S1　71-90　2014
  • 　Proposal of a new disease concept "biliary diseases with pancreatic counterparts". Anatomical and pathological bases.　Nakanuma Y, Harada K, Sasaki M, Sato Y.　Histol Histopathol　29　1　1-10　2014
  • 　Multicentric Castleman Disease With Tubulointerstitial Nephritis Mimicking IgG4-related Disease: Two Case Reports.　Zoshima T, Yamada K, Hara S, Mizushima I, Yamagishi M, Harada K, Sato Y, Kawano M.　Am J Surg Pathol.　40　4　495-501　2016/04
  • 　IgG4-related stomach muscle lesion with a renal pseudotumor and multiple renal rim-like lesions: A rare manifestation of IgG4-related disease. 　Inoue K, Okubo T, Kato T, Shimamura K, Sugita T, Kubota M, Kanaya K,Yamachika D, 　Mod Rheumatol.　18　1-5　2015/09
  • 　Natural killer cells regulate T cell immune responses in primary biliary cirrhosis.　 Shimoda S, Hisamoto S, Harada K, Iwasaka S, Chong Y, Nakamura M, Bekki　Hepatology.　2015/08
  • 　Altered intrahepatic microcirculation of idiopathic portal hypertension in relation to glutamine synthetase expression 　Sato Y, Harada K, Sasaki M, Nakanuma Y.　Hepatol Res　2015
  • 　Autoantibody status and histological variables influence biochemical rewsponse to treatment and long-term outcomes in Japanese patients with primary biliary cirrhosis 　Nakamura M, Kondo H, Tanaka A, Komori A , Ito M, Yamamoto k, Ohira H,Zeniya M, 　Hepatol Res.　45　846-855　2015
  • 　Inflammatory Features of Pancreatic Cancer Highlighted byMonocytes/Macrophages and CD4+ T cells with Clinical Impact.　Komura T, Sakai Y, Harada K, Kawaguchi K, Takabatake H, Kitagawa H, Wada T, 　Cancer Sci.　106　6　672-86　2015/06
  • 　A variant of multicystic biliary hamartoma presenting as an intrahepatic cystic neoplasm.　Tominaga T, Abo T, Kinoshita N, Murakami T, Sato Y, Nakanuma Y, Harada K, 　Clin J Gastroenterol.　2015/05
  • 　Autophagy and senescence in fibrosing cholangiopathies　Nakanuma Y, Sasaki M, Harada K.　Journal of Hepatology　62　934-945　2015
  • 　Growth arrest and DNA damage-inducible 34 regulates liver regeneration in hepatic steatosis in mice.　Inaba Y, Furutani T, Kimura K, Watanabe H, Haga S, Kido Y, Matsumoto M, Yamamoto Y, 　Hepatology.　2015　61(4)　1343-56　2015/04

Conference Presentations

  • Mechanisms of the sclerosing and obstructive cholangiopathy in biliary atresia: Association with biliary innate immunity. (conference：ISSBA シンポジウム2 Etiology and Pathophysiology)(2017/05/12)
  • Classification of　intrahepatic cholangiocarcinoma microenvironment based on immune cell and tumor stromal features(conference：EASL)(2019/04/11)
  • Molecular mechanism of cholangiopathy in PBC(2019)
  • Clinical features of cystatin A expression in patients with pancreatic ductal adenocarcinoma(2019/07/12)
  • IDENTIFICATION OF NOVEL BILIARY EPITHELIAL CELL BIOMARKERS IN PRIMARY BILIARY CHOLANGITIS(PBC)(conference：The Liver Meeting 2019)(2019/11/08)

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  • EFFICACY AND SAFETY OF E6011,ANTI-HUMAN FRACTALKINE MONOCLONAL ANTIBODY, INPATIENTS WITH PRIMARY BILIARY CHOLANGITIS WITH AN INCOMPLETE RESPONSE TO URSODEOXYCHOLIC ACID:A PLACEBO-CONTROLLED DOUBLE-BLIND COMPARISON PHESE 2 STUDY(conference：The Liver Meeting 2019)(2019/11/08)
  • The essence of the bile ductular carcinoma from the viewpoint of surgeon(2017/07/06)
  • CT findings of cholangiolocellular carcinoma in comparison with those of HCC and CCC(2017/07/06)
  • Imatinib Induces Apoptosis of NK/T Cell Neoplasms by Inhibitiong Hematopoietic Cell Kinase and NQO2 (conference：ASH　（AMERICAN　SOCIETY OF HEMATOLOGY）59th Annual meeting 2017)(2017/12/09)
  • Increased expression and altered localization of cathepsis Z is associated with progression to jaundice-stage in primary biliary cholangitis (conference：AASLD The Liver Meeting 2017)(2017/10/20)
  • A cute presentation ofo autoimmune hepatitis in adults and children: histological Spectrum and features distinguishing it from drug-induced liver injury and acute Viral hepatitis.(2017/10/20)
  • Immune-mediated cystatin A expression in patients with pancreatic Ductal adenocarcinoma(conference：ESMO Immuno Oncology Congress 2017)(2017/12/07)
  • Pathology Update 「Recent Pathological Concept of Pancreaticobiliary Diseases」(conference：第７４回日本医学放射線学会総会「Pathology Update 胆・膵」)(2015/04/18)
  • Cholangiocarcinoma with respect IgG4 Reaction(conference：IAP)(2014/10/05)
  • IgG4 reaction in biliary intraepithelial neoplasia and cholangiocarcinoma arising from sclerosing cholangitis(conference：The 102nd USCAP ANNUAL MEETING)(2013/03/02)
  • Energy metabolic change induced by ERRα-PGC-1α axis in chronic non-suppurative destructive cholangitis of primary biliary cirrhosis(conference：The 102nd USCAP ANNUAL MEETING)(2013/03/02)
  • Pathological Differences between IgG4-Related Sclerosing Cholangitis with and without Autoimmune Pancreatitis(conference：The 102nd USCAP ANNUAL MEETING )(2013/03/02)
  • Alteration of energy metabolism and subsequent oxidative stress in the　pathogenesis of cholangiopathy in primary biliary cirrhosis (conference：The Liver Meeting 2013)(2013/11/01)
  • Clinicopathological significance of serum fractalkine and its regulation　by ursodeoxycholic acid in primary biliary cirrhosis (conference：The Liver Meeting 2013 )(2013/11/01)

Others

  • 　Molecular mechanisms of cholangiopathy in primary biliary cirrhosis.　Nakanuma Y　2006
  • 　Intrahepatic bile duct loss in immune-mediated ductopenic biliary diseases with an emphasis on biliary epithelial apoptosis.　Nakanuma Y　2003
  • 　Endotoxin tolerance in human intrahepatic biliary epithelial cells is induced by upregulation of IRAK-M　2006
  • 　Interferon-gamma accelerates NF-kappaB activation of biliary epithelial cells induced by Toll-like receptor and ligand interaction.　2006
  • 　Molecular mechanisms of cholangiopathy in primary biliary cirrhosis.　39(2):55-61　2006//2

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  • 　Molecular mechanisms of cholangiopathy in primary biliary cirrhosis.　39(2)　55-61　2006/02
  • 　Endotoxin tolerance in human intrahepatic biliary epithelial cells is induced by upregulation of IRAK-M.　26(8):935-42　2006/10
  • 　Biliary innate immunity and cholangiopathy.　3:S430-7　2007/10

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○2022「免疫チェックポイント阻害薬による肝障害の病理学的病態解明」(2020-2022)　
○「難治性の肝・胆道疾患に関する調査研究」(2017-2019)　
○「肝細胞癌の分子・遺伝子的亜分類に基づいたradiogenomics」(2017-2019)　
○「原発性胆汁性胆管炎模倣培養系からのゲノム・脂質情報を利用した新規治療法の開発」(2017-2019)　
○「包括的１細胞遺伝子解析法を用いた自己免疫性肝疾患の病理学的解析」(2017-2019)　
○「肝内胆管癌の遺伝子・分子生物学的機構に基づいたイメージバイオマーカーの研究」(2016-2018)　
○「小児期発症の希少難治性肝胆膵疾患における包括的な診断・治療ガイドライン作成に関する研究」(2014-2015)　
○「Ｃ型肝炎ウイルスに起因する肝硬変に対する抗線維化治療薬の開発に関する研究」(2013-2015)　
○「胆道閉鎖症の病態解明－胆道系自然免疫から獲得免疫への連携と自己免疫現象の解析」(2008-2010)　
○「原発性胆汁性肝硬変の胆管細胞アポトーシスにおける自然免疫の関与」(2007-2007)　
○「原発性胆汁性肝硬変の胆管細胞アポトーシスにおける自然免疫の関与」(2007-2007)　
○「原発性胆汁性肝硬変の胆管細胞アポトーシスにおける自然免疫の関与」(2006-2006)　
○「原発性胆汁性肝硬変の肝内胆管細胞培養株の樹立と病態解析への応用」(2005-2005)　
○「原発性胆汁性肝硬変の肝内胆管細胞培養株の樹立と病態解析への応用」(2004-2004)　
○「原発性胆汁性肝硬変における肝内胆管破壊の分子機構」(2003-2003)　
○「原発性胆汁性肝硬変における肝内胆管破壊の分子機構」(2002-2002)　
○「原発性胆汁性肝硬変の肝組織内における疾患特異的抗原成分の検出の試み」(1998-1998)　
○「原発性胆汁性肝硬変の肝組織内における疾患特異的抗原成分の検出の試み」(1997-1998)　
○「原発性胆汁性肝硬変の胆管病変におけるエネルギー代謝の解析と治療戦略」(2014-2016)　
○「原発性胆汁性肝硬変の胆管病変における性ホルモンの関与と治療戦略」(2011-2013)　
○「胆道閉鎖症の病態解明－胆道系自然免疫から獲得免疫への連携と自己免疫現象の解析」(2009-2010)　

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＡ(2022)
○Human Pathology 1(2022)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＡ(2022)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＡ(2022)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＡ(2022)
○Human Pathology 1(2022)
○Human Pathology 2(2022)
○Academic Skills(2022)
○Human Pathology 2(2022)
○Human Pathology 2(2022)
○Human Pathology 2(2022)
○Basic Health Science 2(2022)
○Basic Health Science 1(2022)
○Freshman Seminar I(2019)
○Basic Health Science(2019)
○Human Pathology2(2019)
○Freshman Seminar I(2018)
○Human Pathology2(2018)
○Basic Health Science(2018)
○Freshman Seminar I(2017)
○Basic Health Science(2017)
○Human Pathology(2017)
○Human Pathology(2016)
○Freshman Seminar I(2016)
○Basic Health Science(2016)
○Human Pathology(2016)

Classes (Graduate Schools)

○Human Pathology(2022)
○Human Pathology(2022)
○Morpho-Functional Pathology(2022)
○Morpho-Functional Pathology(2022)
○Human Pathology(2022)
○Human Pathology(2022)
○Morpho-Functional Pathology(2022)
○Morpho-Functional Pathology(2022)
○Medical Sciences(2022)
○Human Pathology(2022)
○Human Pathology(2022)
○Morpho-Functional Pathology(2022)
○Morpho-Functional Pathology(2022)
○Introduction to Basic Medical Science(2022)
○Human Pathology(2022)
○Human Pathology(2022)
○Morpho-Functional Pathology(2022)
○Morpho-Functional Pathology(2022)
○Introduction to Basic Medical Science(2022)
○Human Body: Diseases(2022)
○Pathology and Pathogenesis(2022)
○Medical Sciences(2017)
○Pathology and Pathogenesis(2017)
○Morpho-Functional Pathology(2017)
○Morpho-Functional Pathology(2017)
○Morpho-Functional Pathology(2017)
○Introduction to Basic Medical Science(2016)
○Morpho-Functional Pathology(2016)
○Morpho-Functional Pathology(2016)
○Morpho-Functional Pathology(2016)
○Pathology and Pathogenesis(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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