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Researcher Information

last modified：2024/11/25

Associate Professor　YOSHIOKA Kazuaki

Mail

Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences
Associate Professor

College and School Educational Field

Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Department of Vasucular Molecular Physiology　TEL:076-265-2166　FAX:076-234-4223

Academic Background

【Academic background(Doctoral/Master's Degree)】
Tokyo University of Agriculture and Technology　Doctor　Graduate School, Division of Engineering　Molecular Biotechnology　199803　Completed
【Academic background(Bachelor's Degree)】
Tokyo University of Agriculture and Technology　Industrial Chemistry　199603

Career

Tokyo Metropolitan Institute for Neuroscience　Molecular and Cellular Neurobiology(1999/10/01-2002/04/01)
Bioanalytical Systems, Inc.　Microdialysis(1998/04/01-1999/09/30)

Year & Month of Birth

1969/04

Academic Society






Award

○Young Investigator Award(2006/12/01)
○Mitsubishi Pharma Research Foundation(2004)

Specialities

General physiology

Speciality Keywords

PI3 kinase,Autophagy,Endocytosis,Membrane Trafficking,Signal transduction,contruction-relaxation Smooth muscle cell,Cardiovascular remodeling,Angiogenesis

Research Themes

Single-cell RNA-sequence analysis of adventitial vasa vasorum in human aortic dissection.

Study of physiological role of cardiovascular remodeling using knockout mouse.

Regulation of Pulmonary stem cell function through intracellular clearance.

Regulation of contraction of vascular smooth muscle cells by mechanical stimulus

Books

  • 　Role of sphingosine-1-phosphate signaling in atherosclerosis　John Wiley & Sons　2011/01
  • 　Sphingosine-1-phosphate regulation of macrophages in atherosclerosis　Springer　2011/01

Papers

  • 　Synthesis and structure-activity relationships of selective ligands for P3 purinoceptor-like protein (P3LP)　Nucleic Acids Symposium Series　44　19-20　2000
  • 　Effects of melatonin administration on the release of endogenous 5-HT and its metabolite in rat SCN　Yoshioka, K., Xie, F., Gitzen, J., Kissinger, C. and Kissinger, P　Asian J. Drug Metabolism & Pharmacokinetics　3　265-272　2003/01
  • 　Rho-dependent, Rho kinase-independent inhibitory regulation of Rac and cell migration by LPA1 receptor in Gi-inactivated CHO cells.　Sugimoto, N., Takuwa, N., Yoshioka, K. and Takuwa, Y.　EXPERIMENTAL CELL RESEARCH　312　1899-1908　2006/01
  • 　Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system.　Takuwa Y, Okamoto Y, Yoshioka K, Takuwa N. 　BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS　1781　483-488　2008/01
  • 　Roles of sphingosine-1-phosphate signaling in angiogenesis.　Y Takuwa, W Du, X Qi, Y Okamoto, N Takuwa, K Yoshioka.　World J Biol Chem.　1　10　298-306　2010/01

show all

  • 　Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in Apoe-deficient mice.　JOURNAL OF CLINICAL INVESTIGATION　120　3979-3995　2010/01
  • 　S1P(2), the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice. 　Du W, Takuwa N, Yoshioka K, Okamoto Y, Gonda K, Sugihara K, Fukamizu A, Asano M, Takuwa Y.　CANCER RESEARCH　70　772-781　2010/01
  • 　Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice.　Xun Qi, Yasuo Okamoto, Tomomi Murakawa, Fei Wang, Osamu Oyama, Ryunosuke Ohkawa, Kazuaki Yoshioka, Wa Du, Naotoshi Sugimoto, Yutaka Yatomi, Noriko Takuwa, Yoh Takuwa　EUROPEAN JOURNAL OF PHARMACOLOGY　634　121-131　2010/01
  • 　Sphingosine-1-phosphate signaling and cardiac fibrosis.　Inflammation & Regeneration　33　2　96-108　2013/01
  • 　Sphingoshine-1-phospahte as a mediator involved in development of fibrotic diseases.　BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS　1831　185-192　2013/01
  • 　Sphingosine-1-phosphate receptor-2 protects against anaphylactic shock through suppression of eNOS in mice. 　JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY　132　5　1205-1214　2013
  • 　Class II PI3 kinase C2 alpha has an essential role in angiogenesis and vascular homeostasis through regulating endosomal trafficking　Yoshioka, Kazuaki;Takuwa, Noriko;Okamoto, Yasuo;Takuwa, Yoh　JOURNAL OF PHYSIOLOGICAL SCIENCES　63　0　S98-S98　2013　
  • 　Class II PI3 kinase-C2 alpha plays essential roles in endosomal Rac1 activation and cell migration in S1P-stimulated endothelial cells　Biswas, Kuntal;Yoshioka, Kazuaki;Aki, Sho;Cui Hong;Zhao JuanJuan;Kuda, Yuichi;Takuwa, Noriko;Okamoto, Yasuo;Takuwa, Yoh　JOURNAL OF PHYSIOLOGICAL SCIENCES　63　0　S136-S136　2013　
  • 　Sphingosine-1-phosphate receptor-2 plays a protective role against anaphylactic shock through inhibiting eNOS　Cui Hong;Okamoto, Yasuo;Yoshioka, Kazuaki;Du Wa;Takuwa, Noriko;Zhang Wei;Biswas, Kuntal;Aki, Sho;Zhao JuanJuan;Kuda, Yuichi;Asano, Masahide;Shibamoto, Toshishige;Takuwa, Yoh　JOURNAL OF PHYSIOLOGICAL SCIENCES　63　0　S119-S119　2013　
  • 　Disruption of sphingosine-1-phosphate receptor-2 gene inhibits atherosclerosis in apoE-deficient mice　Wang, Fei;Okamoto, Yasuo;Inoki, Isao;Yoshioka, Kazuaki;Takuwa, Noriko;Takuwa, Yoh　JOURNAL OF PHARMACOLOGICAL SCIENCES　115　0　97P-97P　2011
  • 　[Physiological roles of class II PI3 kinase-C2alpha in endothelial cells].　Yoshioka, Kazuaki; Takuwa, Noriko; Okamoto, Yasuo; Takuwa, Yoh　Seikagaku. The Journal of Japanese Biochemical Society　85　9　775-780　2013/09/01　
  • 　Cardiovascular function of sphingosine 1-phosphate signaling　Okamoto, Yasuo; Yoshioka, Kazuaki; Takuwa, Noriko; Takuwa, Yoh　Seikagaku　83　6　536-544　2011/12/01　
  • 　G protein-coupled sphingosine-1-phosphate receptors: Potential molecular targets for angiogenic and anti-angiogenic therapies　Takuwa, Noriko; Okamoto, Yasuo; Yoshioka, Kazuaki; Takuwa, Yoh　Biomedical Reviews　22　15-29　2011/12/01　
  • 　Enhanced Ca2+-Dependent Activation of Phosphoinositide 3-Kinase Class IIα Isoform-Rho Axis in Blood Vessels of Spontaneously Hypertensive Rats.　HYPERTENSION　56　934-941　2010/01
  • 　Evaluation of 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose, a new fluorescent derivative of glucose, for viability assessment of yeast Candida albicans　K Yoshioka,KB Oh,M Saito,Y Nemoto,H Matsuoka　APPLIED MICROBIOLOGY AND BIOTECHNOLOGY　46　4　400　1996/11
  • 　Determination of melatonin in commercially available products by LCEC and LC/MS/MS　FM Xie,P Wong,K Yoshioka,RG Cooks,PT Kissinger　JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES　21　9　1273　1998
  • 　Intracellular fate of 2-NBDG, a fluorescent probe for glucose uptake activity, in escherichia coli cells　Kazuaki Yoshioka,Mikako Saito,Ki-Bong Oh,Yasuyuki Nemoto,Hideaki Matsuoka,Masahiro Natsume,Hiroshi Abe　Bioscience, Biotechnology and Biochemistry　60　11　1899　1996
  • 　Analysis of olfactory function of the silkworm bombyx mori　Yoshioka, K.,Homma, T.,Matsuoka, H.　Electrochemistry　64　11　1138　1996　
  • 　Development of a novel fluorescent glucose and its application to probe for cell metabolic activity　YOSHIOKA Kazuaki　Doctoral Thesis (Tokyo University of Agriculture and Technology)　12605甲博工第140号　1997/03　
  • 　In vivo microdialysis liquid chromatography tandem mass spectrometry for the on-line monitoring of melatonin in rat　PSH Wong,K Yoshioka,F Xie,PT Kissinger　RAPID COMMUNICATIONS IN MASS SPECTROMETRY　13　5　407　1999
  • 　A novel fluorescent derivative of glucose applicable to the assessment of glucose uptake activity of Escherichia coli　K Yoshioka,H Takahashi,T Homma,M Saito,KB Oh,Y Nemoto,H Matsuoka　BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS　1289　1　5　1996/02
  • 　Purinergic-receptor oligomerization: Implications for neural functions in the central nervous system　H Nakata,K Yoshioka,T Kamiya　NEUROTOXICITY RESEARCH　6　4　291　2004
  • 　Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system　Yoh Takuwa,Yasuo Okamoto,Kazuaki Yoshioka,Noriko Takuwa　BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS　1781　9　483　2008/09
  • 　G(12/13) and G(q) mediate S1P(2)-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase　Shin-ichiro Takashima,Naotoshi Sugimoto,Noriko Takuwa,Yasuo Okamoto,Kazuaki Yoshioka,Masayuki Takamura,Shigeo Takata,Shuichi Kaneko,Yoh Takuwa　CARDIOVASCULAR RESEARCH　79　4　689　2008/09
  • 　Calcium-dependent regulation of Rho and myosin phosphatase in vascular smooth muscle　Yoh Takuwa,Kazuaki Yoshioka,Noriko Takuwa,Yu Wang,Mohammed Ali Azam,Naotoshi Sugimoto　Biomedical Reviews　16　13　2005　
  • 　S1P(3)-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species　Noriko Takuwa,Sei-Ichiro Ohkura,Shin-Ichiro Takashima,Keisuke Ohtani,Yasuo Okamoto,Tamotsu Tanaka,Kaoru Hirano,Soichiro Usui,Fei Wang,Wa Du,Kazuaki Yoshioka,Yoshiko Banno,Motoko Sasaki,Ikuyo Ichi,Miwa Okamura,Naotoshi Sugimoto,Kiyomi Mizugishi,Yasuni Nakanuma,Isao Ishii,Masayuki Takamura,Shuichi Kaneko,Shosuke Kojo,Kiyoshi Satouchi,Kunitoshi Mitumori,Jerold Chun,Yoh Takuwa　CARDIOVASCULAR RESEARCH　85　3　484　2010/02
  • 　Roles of sphingosine-1-phosphate signaling in angiogenesis.　Takuwa Y,Du W,Qi X,Okamoto Y,Takuwa N,Yoshioka K　World J Biol Chem.　1　10　298　2010　
  • 　Ca2+-independent, inhibitory effects of cyclic adenosine 5 '-monophosphate on Ca2+ regulation of phosphoinositide 3-kinase c2 alpha, Rho, and myosin phosphatase in vascular smooth muscle　Mohammed Ali Azam,Kazuaki Yoshioka,Shinsuke Ohkura,Noriko Takuwa,Naotoshi Sugimoto,Koichi Sato,Yoh Takuwa　JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS　320　2　907　2007/02
  • 　Oligomerization of adenosine A(2A) and dopamine D-2 receptors in living cells　T Kamiya,O Saitoh,K Yoshioka,H Nakata　BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　306　2　544　2003/06
  • 　Hetero-oligomerization between adenosine A1 and P2Y1 receptors in living cells: Formation of ATP-sensitive adenosine receptors　Nakata, H.,Yoshioka, K.,Saitoh, O.　Drug Development Research　58　4　340　2003/05　
  • 　The role of class II PI 3-kinase signaling pathway in physiology and diseases. Curr Biodata Targeted Proteins Database.　Takuwa Y,yoshioka K,Okamoto Y,Takuwa N　Current Biodata. Targeted Proteins database　1　2009
  • 　Enhanced Ca2+-Dependent Activation of Phosphoinositide 3-Kinase Class II alpha Isoform-Rho Axis in Blood Vessels of Spontaneously Hypertensive Rats　Young Mi Seok,Mohammed Ali Azam,Yasuo Okamoto,Atsushi Sato,Kazuaki Yoshioka,Masataka Maeda,InKyeom Kim,Yoh Takuwa　HYPERTENSION　56　5　934　2010/11
  • 　Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice　Xun Qi,Yasuo Okamoto,Tomomi Murakawa,Fei Wang,Osamu Oyama,Ryunosuke Ohkawa,Kazuaki Yoshioka,Wa Du,Naotoshi Sugimoto,Yutaka Yatomi,Noriko Takuwa,Yoh Takuwa　EUROPEAN JOURNAL OF PHARMACOLOGY　634　1-3　121　2010/05
  • 　Negative regulation of endothelial morphogenesis and angiogenesis by S1P(2) receptor　Inoki, I,N Takuwa,N Sugimoto,K Yoshioka,S Takata,S Kaneko,Y Takuwa　BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　346　1　293　2006/07
  • 　Rho-dependent, Rho kinase-independent inhibitory regulation of Rac and cell migration by LPA(1) receptor in G(i)-inactivated CHO cells　N Sugimoto,N Takuwa,K Yoshioka,Y Takuwa　EXPERIMENTAL CELL RESEARCH　312　10　1899　2006/06
  • 　Class II phosphoinositide 3-kinase alpha-isoform regulates Rho, myosin phosphatase and contraction in vascular smooth muscle　Y Wang,K Yoshioka,MA Azam,N Takuwa,S Sakurada,Y Kayaba,N Sugimoto,Inoki, I,T Kimura,T Kuwaki,Y Takuwa　BIOCHEMICAL JOURNAL　394　3　581　2006/03
  • 　Functions of heteromeric association between adenosine and P2Y receptors　H Nakata,K Yoshioka,T Kamiya,H Tsuga,K Oyanagi　JOURNAL OF MOLECULAR NEUROSCIENCE　26　2-3　233　2005
  • 　Hetero-oligomerization of adenosine A(1) receptors with P2Y(1) receptors in rat brains　K Yoshioka,R Hosoda,Y Kuroda,H Nakata　FEBS LETTERS　531　2　299　2002/11
  • 　Agonist-promoted heteromeric oligomerization between adenosine A(1) and P2Y(1) receptors in living cells　K Yoshioka,O Saitoh,H Nakata　FEBS LETTERS　523　1-3　147　2002/07
  • 　Heteromeric association creates a P2Y-like adenosine receptor　K Yoshioka,O Saitoh,H Nakata　PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　98　13　7617　2001/06
  • 　Nucleosides and nucleotides. 200. Reinvestigation of 5 '-N-ethylcarboxamidoadenosine derivatives: Structure-activity relationships for P-3 purinoceptor-like proteins　T Umino,K Yoshioka,Y Saitoh,N Minakawa,H Nakata,A Matsuda　JOURNAL OF MEDICINAL CHEMISTRY　44　2　208　2001/01
  • 　ATP- and adenosine-mediated signaling in the central nervous system: Purinergic receptor complex: Generating adenine nucleotide-sensitive adenosine receptors　K Yoshioka,H Nakata　JOURNAL OF PHARMACOLOGICAL SCIENCES　94　2　88　2004/02
  • 　S1P(2), the G Protein-Coupled Receptor for Sphingosine-1-Phosphate, Negatively Regulates Tumor Angiogenesis and Tumor Growth In vivo in Mice　Wa Du,Noriko Takuwa,Kazuaki Yoshioka,Yasuo Okamoto,Koichi Gonda,Kazushi Sugihara,Akiyoshi Fukamizu,Masahide Asano,Yoh Takuwa　CANCER RESEARCH　70　2　772　2010/01
  • 　Pharmacology of a unique adenosine binding site in rat brain using a selective ligand　K Yoshioka,A Matsuda,H Nakata　CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY　28　4　278　2001/04
  • 　Essential role for class II phosphoinositide 3-kinase α-isoform in Ca2+-induced, Rho- and Rho kinase-dependent regulation of myosin phosphatase and contraction in isolated vascular smooth muscle cells　Kazuaki Yoshioka,Naotoshi Sugimoto,Noriko Takuwa,Yoh Takuwa　Molecular Pharmacology　71　3　912　2007/03
  • 　S1P 3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species　Noriko Takuwa,Sei-Ichiro Ohkura,Shin-Ichiro Takashima,Keisuke Ohtani,Yasuo Okamoto,Tamotsu Tanaka,Kaoru Hirano,Soichiro Usui,Fei Wang,Wa Du,Kazuaki Yoshioka,Yoshiko Banno,Motoko Sasaki,Ikuyo Ichi,Miwa Okamura,Naotoshi Sugimoto,Kiyomi Mizugishi,Yasuni Nakanuma,Isao Ishii,Masayuki Takamura,Shuichi Kaneko,Shosuke Kojo,Kiyoshi Satouchi,Kunitoshi Mitumori,Jerold Chun,Yoh Takuwa　Cardiovascular Research　85　3　484　2010/02
  • 　Sphigosine-1-phosphate receptor 1 promotes neointimal hyperplasia in a mouse model of carotid artery injury.　Teppei Kitano,Soichiro Usui,Shin-Ichiro Takashima,Oto Inoue,Chiaki Goten,Ayano Nomura,Kazuaki Yoshioka,Masaki Okajima,Shuichi Kaneko,Yoh Takuwa,Masayuki Takamura　Biochemical and biophysical research communications　511　1　179　2019/03/26
  • 　Sphingosine-1-phosphate-specific G protein-coupled receptors as novel therapeutic targets for atherosclerosis　Yasuo Okamoto,Fei Wang,Kazuaki Yoshioka,Noriko Takuwa,Yoh Takuwa　Pharmaceuticals　4　1　117　2011
  • 　Sphingosine-1-phosphate as a mediator involved in development of fibrotic diseases　Yoh Takuwa,Hitoshi Ikeda,Yasuo Okamoto,Noriko Takuwa,Kazuaki Yoshioka　BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS　1831　1　185　2013/01
  • 　Vascular endothelial S1P 2 receptor limits tumor angiogenesis and hyperpermeability　Noriko Takuwa,Yasuo Okamoto,Kazuaki Yoshioka,Yoh Takuwa　Bioactive Lipid Mediators: Current Reviews and Protocols　237　2015/01/01
  • 　Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice　Hong Cui,Yasuo Okamoto,Kazuaki Yoshioka,Wa Du,Noriko Takuwa,Wei Zhang,Masahide Asano,Toshishige Shibamoto,Yoh Takuwa　Journal of Allergy and Clinical Immunology　132　5　1205　2013/11
  • 　TGFβ receptor endocytosis and Smad signaling require synaptojanin1, PI3K-C2α-, and INPP4B-mediated phosphoinositide conversions.　Sho Aki,Kazuaki Yoshioka,Noriko Takuwa,Yoh Takuwa　Molecular biology of the cell　31　5　360　2020/03/01
  • 　Sphingosine-1-phosphate signaling in physiology and diseases　Yoh Takuwa,Yasuo Okamoto,Kazuaki Yoshioka,Noriko Takuwa　BIOFACTORS　38　5　329　2012/09
  • 　Early endothelialization associated with a biolimus A9 bioresorbable polymer stent in a porcine coronary model　Masayuki Mori,Kenji Sakata,Chiaki Nakanishi,Takuya Nakahashi,Masa-aki Kawashiri,Kazuaki Yoshioka,Yoh Takuwa,Hirofumi Okada,Jun-ichiro Yokawa,Masaya Shimojima,Tsuyoshi Yoshimuta,Shohei Yoshida,Masakazu Yamagishi,Kenshi Hayashi　HEART AND VESSELS　32　10　1244　2017/10
  • 　Endothelial PI3K-C2 alpha, a class II PI3K, has an essential role in angiogenesis and vascular barrier function　Kazuaki Yoshioka,Kotaro Yoshida,Hong Cui,Tomohiko Wakayama,Noriko Takuwa,Yasuo Okamoto,Wa Du,Xun Qi,Ken Asanuma,Kazushi Sugihara,Sho Aki,Hidekazu Miyazawa,Kuntal Biswas,Chisa Nagakura,Masaya Ueno,Shoichi Iseki,Robert J. Schwartz,Hiroshi Okamoto,Takehiko Sasaki,Osamu Matsui,Masahide Asano,Ralf H. Adams,Nobuyuki Takakura,Yoh Takuwa　NATURE MEDICINE　18　10　1560　2012/10
  • 　Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages　Juanjuan Zhao,Yasuo Okamoto,Yuya Asano,Kazuhiro Ishimaru,Sho Aki,Kazuaki Yoshioka,Noriko Takuwa,Takashi Wada,Yutaka Inagaki,Chiaki Takahashi,Takumi Nishiuchi,Yoh Takuwa　PLoS ONE　13　5　e0197604　2018/05/01
  • 　Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling　Ioannis Serafimidis,Eva Rodriguez-Aznar,Mathias Lesche,Kazuaki Yoshioka,Yoh Takuwa,Andreas Dahl,Duojia Pan,Anthony Gavalas　PLOS BIOLOGY　15　3　2017/03
  • 　Sphingosine kinase-2 prevents macrophage cholesterol accumulation and atherosclerosis by stimulating autophagic lipid degradation　Ishimaru K,Yoshioka K,Kano K,Kurano M,Saigusa D,Aoki J,Yatomi Y,Takuwa N,Okamoto Y,Proia R,Takuwa Y　SCIENTIFIC REPORT　9　1　13829　2019/12
  • 　Everolimus-Eluting Biodegradable Abluminal Coating Stent versus Durable Conformal Coating Stent: Termination of the Inflammatory Response Associated with Neointimal Healing in a Porcine Coronary Model.　Masayuki Mori,Kenji Sakata,Junichiro Yokawa,Chiaki Nakanishi,Kota Murai,Hirofumi Okada,Masaya Shimojima,Shohei Yoshida,Kazuaki Yoshioka,Yoh Takuwa,Kenshi Hayashi,Masakazu Yamagishi,Masa-Aki Kawashiri　Journal of interventional cardiology　2020　8　1956015　2020
  • 　G protein-coupled sphingosine-1-phosphate receptors: Potential molecular targets for angiogenic and anti-angiogenic therapies　Noriko Takuwa,Yasuo Okamoto,Kazuaki Yoshioka,Yoh Takuwa　Biomedical Reviews　22　15　2011
  • 　Overexpression of Sphingosine Kinase 1 Prevents Ceramide Accumulation and Ameliorates Muscle Insulin Resistance in High-Fat Diet-Fed Mice　Clinton R. Bruce,Steve Risis,Joanne R. Babb,Christine Yang,Greg M. Kowalski,Ahrathy Selathurai,Robert S. Lee-Young,Jacquelyn M. Weir,Kazuaki Yoshioka,Yoh Takuwa,Peter J. Meikle,Stuart M. Pitson,Mark A. Febbraio　DIABETES　61　12　3148　2012/12
  • 　Sphingosine-1-Phosphate Signaling and Cardiac Fibrosis.　Takuwa N,Okamoto Y,Yoshioka K,Takuwa Y　Inflammation and Regeneration　33　2　96　2013　
  • 　Essential Role of Class II Phosphatidylinositol-3-kinase-C2 alpha in Sphingosine 1-Phosphate Receptor-1-mediated Signaling and Migration in Endothelial Cells　Kuntal Biswas,Kazuaki Yoshioka,Ken Asanuma,Yasuo Okamoto,Noriko Takuwa,Takehiko Sasaki,Yoh Takuwa　JOURNAL OF BIOLOGICAL CHEMISTRY　288　4　2325　2013/01
  • 　Analysis of various types of single-polypeptide-chain (sc) heterodimeric A(2A)R/D2R complexes and their allosteric receptor receptor interactions　Toshio Kamiya,Kazuaki Yoshioka,Hiroyasu Nakata　BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　456　2　573　2015/01
  • 　Phosphatidylinositol 3-Kinase Class II alpha-Isoform PI3K-C2 alpha Is Required for Transforming Growth Factor beta-induced Smad Signaling in Endothelial Cells　Sho Aki,Kazuaki Yoshioka,Yasuo Okamoto,Noriko Takuwa,Yoh Takuwa　JOURNAL OF BIOLOGICAL CHEMISTRY　290　10　6086　2015/03
  • 　Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6　Sei-ichiro Ohkura,Soichiro Usui,Shin-ichiro Takashima,Noriko Takuwa,Kazuaki Yoshioka,Yasuo Okamoto,Yutaka Inagaki,Naotoshi Sugimoto,Teppei Kitano,Masayuki Takamura,Takashi Wada,Shuichi Kaneko,Yoh Takuwa　PLOS ONE　12　8　e0182329　2017/08
  • 　Photoacoustic imaging of tumour vascular permeability with indocyanine green in a mouse model.　Kenichiro Okumura,Kotaro Yoshida,Kazuaki Yoshioka,Sho Aki,Norihide Yoneda,Dai Inoue,Azusa Kitao,Takahiro Ogi,Kazuto Kozaka,Tetsuya Minami,Wataru Koda,Satoshi Kobayashi,Yoh Takuwa,Toshifumi Gabata　European radiology experimental　2　1　5　2018
  • 　LPA-induced YAP/TAZ activation promotes developmental angiogenesis by regulating Dll4 expression　Yasuda D,Kobayashi D,Akahoshi N,Ohto-Nakanishi T,Yoshioka K,Takuwa Y,Mizuno S,Takahashi S,Ishii S　J Clin Invest　129　10　4332　2019
  • 　Lysophosphatidic acid-induced YAP/TAZ activation promotes developmental angiogenesis by repressing Notch ligand Dll4　Yasuda Daisuke,Kobayashi Daiki,Akahoshi Noriyuki,Ohto-Nakanishi Takayo,Yoshioka Kazuaki,Takuwa Yoh,Mizuno Seiya,Takahashi Satoru,Ishii Satoshi　JOURNAL OF CLINICAL INVESTIGATION　129　10　4332　2019/10
  • 　Class II phosphatidylinositol 3-kinase α and β isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice.　Shahidul Islam,Kazuaki Yoshioka,Sho Aki,Kazuhiro Ishimaru,Hiroki Yamada,Noriko Takuwa,Yoh Takuwa　The journal of physiological sciences : JPS　70　1　18　2020/03/19
  • 　Class II phosphatidylinositol 3-kinase isoforms in vesicular trafficking　Kazuaki Yoshioka　Biochemical Society Transactions　49　2　893　2021/04/30　
  • 　MTMR4, a phosphoinositide‐specific 3’‐phosphatase, regulates TFEB activity and the endocytic and autophagic pathways　Hoa Q. Pham,Kazuaki Yoshioka,Hiromi Mohri,Hiroki Nakata,Sho Aki,Kazuhiro Ishimaru,Noriko Takuwa,Yoh Takuwa　Genes to Cells　23　8　670　2018/08　
  • 　Aldosterone inhibits endothelial morphogenesis and angiogenesis through the downregulation of vascular endothelial growth factor receptor-2 expression subsequent to peroxisome proliferator-activated receptor gamma　Miki Fujii,Isao Inoki,Makoto Saga,Norihiro Morikawa,Ken-ichiro Arakawa,Satoru Inaba,Kazuaki Yoshioka,Tadashi Konoshita,Isamu Miyamori　JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY　129　3-5　145　2012/04
  • 　Sphingosine-1-phosphate as a mediator involved in development of fibrotic diseases　Takuwa, Y.,Ikeda, H.,Okamoto, Y.,Takuwa, N.,Yoshioka, K.　Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids　1831　1　185　2013/01　
  • 　Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1　Noriko Takuwa,Wa Du,Erika Kaneko,Yasuo Okamoto,Kazuaki Yoshioka,Yoh Takuwa　AMERICAN JOURNAL OF CANCER RESEARCH　1　4　460　2011　
  • 　Class II PI3Ks α and β Are Required for Rho-Dependent Uterine Smooth Muscle Contraction and Parturition in Mice　Md Azadul Kabir Sarker,Sho Aki,Kazuaki Yoshioka,Kouji Kuno,Yasuo Okamoto,Kazuhiro Ishimaru,Noriko Takuwa,Yoh Takuwa　Endocrinology　160　1　235　2019/01/01　
  • 　The class II phosphoinositide 3-kinases PI3K-C2α and PI3K-C2β differentially regulate clathrin-dependent pinocytosis in human vascular endothelial cells　Aung, K.T.,Yoshioka, K.,Aki, S.,Ishimaru, K.,Takuwa, N.,Takuwa, Y.　Journal of Physiological Sciences　69　2　263　2019/03　
  • 　Adipose-Derived Stem Cell Sheets Promote Meniscus Regeneration Regardless of Whether the Defect Involves the Inner Half or the Whole Width of the Anterior Half of the Medial Meniscus in a Rabbit Model　Kazuki Asai,Junsuke Nakase,Kazuaki Yoshioka,Rikuto Yoshimizu,Mitsuhiro Kimura,Hiroyuki Tsuchiya　Arthroscopy　38　9　2672　2022/09
  • 　The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery　Kiren Baines,Kazuaki Yoshioka,Yoh Takuwa,Jon D. Lane　Autophagy Reports　1　1　88　2021/12/31　
  • 　Suppression of androgen receptor signaling induces prostate cancer migration via activation of the CCL20–CCR6 axis　Kano, Hiroshi,Izumi, Kouji,Hiratsuka, Kaoru,Toriumi, Ren,Nakagawa, Ryunosuke,Aoyama, Shuhei,Kamijima, Taiki,Shimada, Takafumi,Naito, Renato,Kadomoto, Suguru,Iwamoto, Hiroaki,Yaegashi, Hiroshi,Kawaguchi, Shohei,Nohara, Takahiro,Shigehara, Kazuyoshi,Kadono, Yoshifumi,Saito, Yohei,Nakagawa-Goto, Kyoko,Yoshioka, Kazuaki,Nakata, Hiroki,Lin, Wen-Jye,Mizokami, Atsushi　Cancer Science　114　4　1479　2023/04
  • 　Class II phosphatidylinositol 3-kinase-C2α is essential for Notch signaling by regulating the endocytosis of γ-secretase in endothelial cells　Shota Shimizu,Kazuaki Yoshioka,Sho Aki,Yoh Takuwa　Scientific Reports　11　1　2021/12　
  • 　Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice (Journal of Clinical Investigation (2010) 120, 11, (3979-3995) DOI:10.1172/JCI42315)　Wang F,Okamoto Y,Inoki I,Yoshioka K,Du W,Qi X,Takuwa N,Gonda K,Yamamoto Y,Ohkawa R,Nishiuchi T,Sugimoto N,Yatomi Y,Mitsumori K,Asano M,Kinoshita M,Takuwa Y　Journal of Clinical Investigation　122　3　1131　2012/03　
  • 　Differences in Collagen Types in the Semitendinosus, Quadriceps, and Patellar Tendons: The Report Using Samples from the Same Individual.　Yushin Mizuno, Junsuke Nakase, Kazuaki Yoshioka, Takuya Sengoku, Rikuto Yoshimizu, Tomoyuki Kanayama, Yusuke Yanatori, Hiroyuki Tsuchiya　The Knee　in press　2023

Conference Presentations

  • Essential role of class II PI3K in endocytosis and endosomal signaling(conference：9th Federation of the Asia and Oceanian Physiological Societies (FAOPS2019) )(2019/03/28)
  • Class II phosphoinositide 3-kinase isoforms PI3K-C2α and PI3K-C2β play essential roles in pinocytosis in vascular endothelial cells(2018/03/28)
  • Indispensable role of α and β isoforms of class II phosphoinositide 3-kinases (PI3K) in the uterine smooth muscle contraction during labor(2018/03/28)
  • Myotubularin-related protein 4 (MTMR4), a phosphoinositide 3'-phosphatase, regulates endolysosome integrity and autophagy flux in human lung alveolar epithelial A549 cells(2018/03/28)
  • Endothelial Class II PI3K-C2α is necessary for vascular formation and integrity through regulating endocytic membrane trafficking(2017/03/18)

show all

  • PI3K-C2α is required for TGFβ-induced receptor endocytosis and endosomal signaling in endothelial cells.(2016/03/24)
  • Sphingosine 1-phosohate receptor-2 plays a protective role against lopopolysaccharide (LPS)-induced acute lung injury(2016/03/22)
  • Sphingosine-1-phosphate receptor-2 plays a protective role against anaphylactic shock through inhibiting eNOS.(2013)
  • Essential role of class Iiα-isoform PI3 kinase C2α in sphingosine-1-phosphate (S1P)-induced endothelial cell migration.(2013/03/28)
  • Class II PI3 kinase, PI3K-C2α, mediates S1P-induced endothelial cell migration through endosomal Rac1 activation.(conference：Gordon Research Conference on Vascular Cell Biology)(2013/02/01)
  • Class II PI3K-C2α is essential for vascular barrier integrity.” JST-CREST International Symposium “Frontiers in Immunology and Inflammation: From Molecules and Inflammation(conference：JST-CREST International Symposium “Frontiers in Immunology and Inflammation: From Molecules and Inflammation.”)(2013/02/13)
  • 蛍光イメージングが拓く見せる血管生物学(2013/09/26)
  • Endothelial class II PI3K-C2α has an essential role in vascular formation and barrier function(conference：Gordon Research Conference on Vascular Cell Biology)(2013/02/01)
  • クラスII型PI3キナーゼC2αは血管形成・血管恒常性維持に必須である(2012/12/14)
  • Class II phosphatidylinositol 3-kinase α and β isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice(conference：The 98th Annual Meeting of The Physiological Society of Japan)(2021/03/29)
  • イノシトールリン脂質特異的3’-ホスファターゼMTMR4はリソソーム機能・オートファジーを制御する(conference：第94 回日本生理学会大会)(2017/03/28)

Others

  • 　Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system.　Takuwa Y, Okamoto Y, Yoshioka K, Takuwa N.　1781　2008
  • 　CALCIUM-DEPENDENT REGULATION OF RHO AND MYOSIN PHOSPHATASE IN VASCULAR SMOOTH MUSCLE　Takuwa Y., Yoshioka K., Takuwa N., Wang Yu., Azam M.A., Sugimoto N.　16　2005
  • 　Functions of Heteromeric Association Between Adenosine and P2Y Receptors.　Nakata, H., Yoshioka, K., Kamiya, T., Tsuga, H., and Oyanagi, K.　26　2005
  • 　ATP- and adenosine-Mediated Signaling in the Central Nervous System: Purinergic Receptor Complex: Generating Adenosine Nucleotide-Sensitive Adenosine Receptors.　Yoshioka, K., Nakata, H.　94　2004

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「2型PI3キナーゼα酵素による細胞内小胞輸送調節を介した物質・情報交換制御の機構」(2011-2013)　
○「心血管ホメオスターシスとその破綻における機能性脂質の役割」(2009-2011)　
○「KO マウスを用いたクラスⅡ型PI3 キナーゼC2α の血管形成における役割」(2008-2010)　
○「がん血行転移を制御するシグナリング機構」(2007-)　
○「伸展力を介した血管平滑筋トーヌスのカルシウム感受性制御」(2004-)　
○「膜動現象を制御するイノシトールリン脂質脱リン酸化酵素の肺発達・成熟における役割」(2017-2019)　
○「血管内皮機能に必須なPI(3)P代謝酵素によるメンブレン・トラフィック制御」(2014-2016)

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Basic Health Science(2018)
○Organ Physiology(2018)
○Basic Health Science(2017)
○Organ Physiology(2017)
○Basic Physiology(2016)
○Basic Health Science(2016)
○Basic Physiology(2015)
○Basic Physiology(2014)
○Basic Physiology(2013)

Classes (Graduate Schools)

○Human Body: Functions(2018)
○The Function of the Human Body(2018)
○The Function of the Human Body(2018)
○Signal Transduction in the Vascular System(2018)
○The Function of the Human Body(2017)
○Signal Transduction in the Vascular System(2017)
○Signal Transduction in the Vascular System(2017)
○The Function of the Human Body(2016)
○Signal Transduction in the Vascular System(2016)
○Signal Transduction in the Vascular System(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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