Specialities

Neuroimmunology, neurosurgery, and stem cell biology

Speciality Keywords

Evolution and neuro-regeneration, neuro-immune association; subarachnoid hemorrhage (SAH), cerebral vasospasm; spinal cord injury (SCI), unfolded protein response-induced inflammation, microglia

Research Themes

Books

• 　ISHII, Hiroshi; YAMASHITA, Toshihide; Editorial board member: YUZAKI, Michisuke　DOI：10.14931/bsd.489　Heat shock protein, Brain Science Dictionary　The Japan Neuroscience Society, Brain Science Dictionary Editorial Borad　2012/02

Papers

• 　CD150high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine.　Hirata Y, Furuhashi K, Ishii H, Li HW, Pinho S, Ding L, Robson SC, Frenette PS, Fujisaki J　　　　　　Cell Stem Cell, Cell Press　22　3　445-453　2018/03/01　
• 　N-myc downstream-regulated gene 2 protects blood-brain barrier integrity following cerebral ischemia.　　　　Takarada-Iemata M, Yoshikawa A, Ta HM, Okitani N, Nishiuchi T, Aida Y, Kamide T, Hattori T, Ishii H, Tamatani T, Le TM, Roboon J, Kitao Y, Matsuyama T, Nakada M, Hori O.　Glia, Wiley Online Library, Epub ahead of print. 　　　　　北國新聞、QLifePro 医療ニュースで取り上げられた。　2018/02/24　
• 　Ndrg2 deficiency ameliorates neurodegeneration in experimental autoimmune encephalomyelitis.　Le TM, Takarada-Iemata M, Ta HM, Roboon J, Ishii H, Tamatani T, Kitao Y, Hattori T, Hori O.　J Neurochem, The International Society for Neurochemistry, in press.　2018/02/19　
• 　CD38 positively regulates postnatal development of astrocytes cell-autonomously and oligodendrocytes non-cell-autonomously.　Hattori T, Kaji M, Ishii H, Jureepon R, Takarada-Iemata M, Minh Ta H, Manh Le T, Konno A, Hirai H, Shiraishi Y, Ozaki N, Yamamoto Y, Okamoto H, Yokoyama S, Higashida H, Kitao Y, Hori O.　Glia, Wiley Periodicals, Epub ahead of print. 　　　北國新聞、Yahooニュース、中日新聞、QLifePro 医療ニュース、日本の研究.comで取り上げられた。　2017/03/13　
• 　Atf6α deficiency suppresses microglial activation and ameliorates pathology of experimental autoimmune encephalomyelitis.　Ta HM, Le TM, Ishii H, Takarada-Iemata M, Hattori T, Hashida K, Yamamoto Y, Mori K, Takahashi R, Kitao Y, Hori O.　J Neurochem, The International Society for Neurochemistry, Epub ahead of print. 　表紙を飾った。筆頭著者は第38回日本生物学的精神医学会・第59回日本神経化学会大会 合同年会（2016年9月、福岡）にて優秀発表者賞を受賞した。　2016/07/18　

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Conference Presentations

• Transfer of Th1 cells promotes recovery from spinal cord injury. (conference：FASEB Summer Conference on Translational Neuroimmunology: From Mechanisms to Therapeutics, Carefree, Arizona, USA)(2012/07/31)
• Implantation of Th1 cells ameliorates recovery after spinal cord injury. (conference：Neuro2010, The 33rd Annual Meeting of the Japan Neuroscience Society, Kobe, Japan)(2010/09/02)
• Case study of herpes simplex encephalitis that developed with symptom of afebrile headache. (conference：Forum of Mie Medical Complex, Post Graduate Medical Training)(2007/01)

Others

Arts and Fieldwork

Patent

○COMPOSITION FOR TREATING CENTRAL NERVE DAMAGE, AND USE THEREOF, WO125531 (publish date：2013/08/29)
○Composition for Treating Central Nerve Damage, and use thereof. Pub. No. 2015-091761 Japan Patent (publish date：2015/05/14)

Theme to the desired joint research

○1. Neuro-regeneration and immunology 2. Evolution and CNS diseases; I am skilled in analysis of the central nervous system using flow cytometry/cell sorter. I am look forward to collaborating with scientists/clinicians who are interested in similar theme to mine and, dedicated in or interested in live imaging with techniques such as multi-photon excitation microscopy.

Grant-in-Aid for Scientific Research

○Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))「Developing novel therapy for subarachnoid hemorrhage」(2018-2021)　
○Grant-in-Aid for Scientific Research (C)「Elucidation of molecular mechanisms underlying vasospasm after subarachnoid hemorrhage.」(2017-2019)　
○Grant-in-Aid for Young Scientists (Start-up)「Functions of adoptive immune system after injury of the central nervous system and immunomodulatory treatment」(2012-2013)　

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Freshman Seminar I(2017)
○Embryology(2017)
○Neuroanatomy(2017)
○Neuroanatomy(2016)
○Human Embryology(2016)

Classes (Graduate Schools)

○Principles of Anatomy(2017)
○Molecular Targeting in the Central Nervous System(2017)
○Molecular Targeting in the Central Nervous System(2017)
○Molecular Targeting in the Central Nervous System(2016)
○Molecular Targeting in the Central Nervous System(2016)
○Principles of Anatomy(2016)