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Researcher Information

last modified：2024/11/21

Associate Professor　Karashima Shigehiro

Faculty, Affiliation

Institute of Liberal Arts and Science

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Medicine, Graduate School of Medical Science
Faculty of Global Standard Education, Institute of Liberal Arts and Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Academic Background

Career

Year & Month of Birth

Academic Society

The Japanese Circulation Society
THE MASS SPECTROMETRY SOCIETY OF JAPAN


THE JAPANESE SOCIETY OF INTERNAL MEDICINE

JAPAN SOCIETY FOR THE STUDY OF OBESITY
THE JAPAN DIABETES SOCIETY
The Japan Endocrine Society







Award

Specialities

Epidemiology and preventive medicine、Metabolomics、Endocrinology

Speciality Keywords

Research Themes

The relationship between steroid hormone and life style diseases

Books

Papers

  • 　Raised aldosterone benin ratio predicts aldosterone breakthrough phenomenonin hypetensive patients treated with angiotensin-II receptor blocker　Takashi Yoneda,Yoshiyu Takeda,Mikiya Usukura,Hiroyuki Takada,Shigehiro Karashima,Tomoko Sakai,Masakazu Yamagishi　JOURNAL OF HYPERTENSION　24　228　2006/12
  • 　Effect of telmisartan on insulin resistance in hypertensive patients with obesity　Takashi Yoneda,Yoshiyu Takeda,Mikiya Usukura,Hiroyuki Takada,Shigehiro Karashima,Tomoko Sakai,Masakazu Yamagishi　JOURNAL OF HYPERTENSION　24　296　2006/12
  • 　Raised aldosterone to renin ratio predicts increased rate of cardiovascular and renal events in patients with essential hypertension.　Hiroyuki takata,Yoshiyu Takeda,Takashi Yoneda,Mikiya Usukura,Shigehiro Karashima,Satoko Sakai,Aoshuang Zhu　JOURNAL OF HYPERTENSION　24　302　2006/12
  • 　Effect of eplerenone, a selective aldosterone blocker, on adiposal renin-angiotensin-aldosterone system in saltsensitive hypertensive rats　Aoshuang Zhu,Yoshiyu Takeda,Mikiya Usukura,Takashi Yoneda,Hiroyuki Takata,Shigehiro Karashima,Satoko Sakai,Masakazu Yamagishi　JOURNAL OF HYPERTENSION　24　312　2006/12
  • 　Effects of candesartan and eplerenone on cardiac renin-angiotensin-aldosteroen system in experimental salt-sensitive hypertension　Yoshiyu Takeda,Aoshuang Zhu,Takashi Yoneda,Mikiya Usukura,Hiroyuki Takata,Shigehiro Karashima,Satoko Sakai,Masakazu Yamagishi　JOURNAL OF HYPERTENSION　24　312　2006/12

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  • 　Aldosterone breakthrough during angiotensin II receptor blockade in hypertensive patients with diabetes mellitus　Takashi Yoneda,Yoshiyu Takeda,Mikiya Usukura,Nobushige Oda,Hiroyuki Takata,Yasuhiro Yamamoto,Shigehiro Karashima,Masakaz Yamagishi　AMERICAN JOURNAL OF HYPERTENSION　20　12　1329　2007/12
  • 　Effect of mineralocorticoid receptor blockade on the renal renin-angiotensin system in Dahl salt-sensitive hypertensive rats　Aoshuang Zhu,Takashi Yoneda,Masashi Demura,Shigehiro Karashima,Mikiya Usukura,Masakazu Yamagishi,Yoshiyu Takeda　JOURNAL OF HYPERTENSION　27　4　800　2009/04
  • 　A possible new syndrome with double endocrine tumors in association with an unprecedented type of familial heart-hand syndrome: A Case report　Masashi Demura,Takashi Yoneda,Shigehiro Karashima,Toshinori Higashikata,Hiroshi Mabuchi,Mitsuhiro Kawano,Masakazu Yamagishi,Yoshiyu Takeda　Journal of Medical Case Reports　4　1　347　2010
  • 　Epigenetic transcriptional repression of the human CYP11B2 gene　Masashi Demura,Fen Wang,Takashi Yoneda,Shigehiro Karashima,Yuan Cheng,Masakazu Yamagishi,Yoshiyu Takeda　ENDOCRINE JOURNAL　57　S339　2010/03
  • 　Effects of the blockade of angiotensin II and aldosterone on the experimental diabetic neuropathy　Yoshiyu Takeda,Hiroyuki Takata,Shigehiro Karashima,Mitsuhiro Kometani,Masashi Ohe,Masashi Demura,Shunsuke Mori,Yuan Cheng,Takashi Yoneda　ENDOCRINE JOURNAL　57　S646　2010/03
  • 　Ectopic Production of Parathyroid Hormone in a Patient with Sporadic Medullary Thyroid Cancer　Masashi Demura,Takashi Yoneda,Fen Wang,Yoh Zen,Shigehiro Karashima,Aoshuang Zhu,Yuan Cheng,Masakazu Yamagishi,Yoshiyu Takeda　ENDOCRINE JOURNAL　57　2　161　2010/02
  • 　Aldosterone breakthrough during combination therapy with angiotensin II receptor blocker and low dose diuretic in hypertensive patients with diabetes mellitus　Takashi Yoneda,Yoshiyu Takeda,Shigehiro Karashima,Masashi Demura,Mikiya Usukura,Hiroyuki Takata,Nobushige Oda,Yasuhiro Yamamoto,Atsushi Hashimoto,Shunsuke Mori,Mitsuhiro Kometani,Masashi Ooe,Masakazu Yamagishi　ENDOCRINE JOURNAL　57　S552　2010/03
  • 　Alcohol-induced big ACTH production in a patient with pseudo-Cushing's syndrome　Shigehiro Karashima,Toshitaka Sawamura,Masashi Ohe,Mitsuhiro Kometani,Masashi Demura,Shunsuke Mori,Takashi Yoneda,Yoshiyu Takeda　ENDOCRINE JOURNAL　57　S514　2010/03
  • 　Effect of eplerenone, a selective aldosterone blocker, on severe hypokalemia in a patient with big IGFII-producing non-islet cell tumor　Shigehiro Karashima,Mitsuhiro Kometani,Masashi Ohe,Masashi Demura,Shunsuke Mori,Takashi Yoneda,Yoshiyu Takeda　ENDOCRINE JOURNAL　57　S593　2010/03
  • 　Serotonin receptor in aldosterone producing adenoma : Implication for aldosterone secretion　Isamu Miyamori,Miki Fujii,Satoru Inaba,Isao Inoki,Tadashi Konoshita,Yoshiyu Takeda,Takashi Yoneda,Shigehiro Karashima　ENDOCRINE JOURNAL　57　S637　2010/03
  • 　Aldosterone blockade improves visceral fat area in patients with primary aldosteronism　Shigehiro Karashima,Masashi Ohe,Mitsuhiro Kometani,Masashi Demura,Shunsuke Mori,Yasuhiro Yamamoto,Takashi Yoneda,Yoshiyu Takeda　ENDOCRINE JOURNAL　57　S646　2010/03
  • 　Prevalence of primary aldosteronism among prehypertensive and stage 1 hypertensive subjects　Yuji Ito,Ryoyu Takeda,Shigehiro Karashima,Yasuhiro Yamamoto,Takashi Yoneda,Yoshiyu Takeda　HYPERTENSION RESEARCH　34　1　98　2011/01
  • 　Effects of a high-salt diet on adipocyte glucocorticoid receptor and 11-beta hydroxysteroid dehydrogenase 1 in salt-sensitive hypertensive rats　Mikiya Usukura,Aoshuang Zhu,Takashi Yoneda,Shigehiro Karashima,Kunimasa Yagi,Masakazu Yamagishi,Yoshiyu Takeda　STEROIDS　74　12　978　2009/11
  • 　Effects of eplerenone, a selective aldosterone blocker, on blood pressure and organ damage in adrenalectomized hypertensive rats　Yoshiyu Takeda,Aoshuang Zhu,Takashi Yoneda,Mikiya Usukura,Hiroyuki Takata,Shigehiro Karashima,Satoko Sakai,Masakazu Yamagishi　JOURNAL OF HYPERTENSION　24　85　2006/12
  • 　Effects of high sodium diet on adiposal renin-angiotensin-aldosterone system in stroke-prone spontaneously hypertensive rats　Mikiya Usukura,Yoshiyu Takeda,Aoshuang Zhu,Takashi Yoneda,Hiroyuki Takata,Shigehiro Karashima,Satoko Sakai,Masakazu Yamagishi　JOURNAL OF HYPERTENSION　24　157　2006/12
  • 　The Long-term Effect of Adrenal Arterial Embolization for Unilateral Primary Aldosteronism on Cardiorenovascular Protection, Blood Pressure, and the Endocrinological Profile　Mitsuhiro Kometani,Takashi Yoneda,Masashi Demura,Shigehiro Karashima,Shunsuke Mori,Masashi Oe,Toshitaka Sawamura,Rika Okuda,Masakazu Yamagishi,Yoshiyu Takeda　INTERNAL MEDICINE　55　7　769　2016
  • 　Unilateral Primary Aldosteronism with Spontaneous Remission after Long-Term Spironolactone Therapy　Takashi Yoneda,Masashi Demura,Hiroyuki Takata,Mitsuhiro Kometani,Shigehiro Karashima,Masakazu Yamagishi,Yoshiyu Takeda　JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM　97　4　1109　2012/04
  • 　Primary aldosteronism, diagnosis and treatment in Japan　Yoshiyu Takeda,Shigehoro Karashima,Takashi Yoneda　Reviews in Endocrine and Metabolic Disorders　12　1　21　2011/03
  • 　Clinical characteristics of primary hyperaldosteronism due to adrenal microadenoma　Shigehiro Karashima,Yoshiyu Takeda,Yuan Cheng,Takashi Yoneda,Masashi Demura,Mitsuhiro Kometani,Masashi Ohe,Shunsuke Mori,Kunimasa Yagi,Masakazu Yamagishi　STEROIDS　76　12　1363　2011/11
  • 　Protective effects of mineralocorticoid receptor blockade against neuropathy in experimental diabetic rats　H. Takata,Y. Takeda,A. Zhu,Y. Cheng,T. Yoneda,M. Demura,K. Yagi,S. Karashima,M. Yamagishi　DIABETES OBESITY & METABOLISM　14　2　155　2012/02
  • 　Severe Mitral Regurgitation As a Result of Rupture of Mitral Valve Chordae Tendineae in a Patient With Graves Disease　Shigehiro Karashima,Toyonobu Tsuda,Mitsuhiro Kometani,Rie Oka,Masashi Demura,Masa-aki Kawashiri,Yoshiyu Takeda,Kenshi Hayashi,Takashi Yoneda　Journal of the Endocrine Society　2　11　1246　2018/11/01　
  • 　Ventricular Fibrillation Associated With Dynamic Changes in J-Point Elevation in a Patient With Silent Thyroiditis　Shigehiro Karashima,Toyonobu Tsuda,Yusuke Wakabayashi,Mitsuhiro Kometani,Masashi Demura,Taro Ichise,Masa-aki Kawashiri,Yoshiyu Takeda,Kenshi Hayashi,Takashi Yoneda　Journal of the Endocrine Society　2　2　135　2018/02/01　
  • 　Insulin Secretion and Risk for Future Diabetes in Subjects with a Nonpositive Insulinogenic Index.　Daisuke Aono,Rie Oka,Mitsuhiro Kometani,Yoshimichi Takeda,Shigehiro Karashima,Kenichi Yoshimura,Yoshiyu Takeda,Takashi Yoneda　Journal of diabetes research　2018　5107589　2018
  • 　The status of glycemic control and hypoglycemia in elderly patients visiting the outpatient department specializing in diabetes　Yui Soma,Rie Oka,Sumie Fujii,Naoko Ito,Mitsuhiro Kometani,Shigehiro Karashima,Yoshiyu Takeda,Takashi Yoneda,Akimichi Asano　Japanese Journal of Geriatrics　55　2　268　2018
  • 　Age-dependent Increases in Adrenal Cytochrome b5 and Serum 5-Androstenediol-3-sulfate　Juilee Rege,Shigehiro Karashima,Antonio M. Lerario,Joshua M. Smith,Richard J. Auchus,Josephine Z. Kasa-Vubu,Hironobu Sasano,Yasuhiro Nakamura,Perrin C. White,William E. Rainey　JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM　101　12　4585　2016/12
  • 　Impact of New Quick Gold Nanoparticle-Based Cortisol Assay During Adrenal Vein Sampling for Primary Aldosteronism　Takashi Yoneda,Shigehiro Karashima,Mitsuhiro Kometani,Mikiya Usukura,Masashi Demura,Junichirou Sanada,Tetsuya Minami,Wataru Koda,Toshifumi Gabata,Osamu Matsui,Koutarou Idegami,Yuzuru Takamura,Eiichi Tamiya,Masashi Oe,Masuo Nakai,Shunsuke Mori,Noboru Terayama,Yuichi Matsuda,Kouhei Kamemura,Sumie Fujii,Takashi Seta,Toshitaka Sawamura,Rika Okuda,Yoshimichi Takeda,Kenshi Hayashi,Masakazu Yamagishi,Yoshiyu Takeda　JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM　101　6　2554　2016/06
  • 　double dagger@ Epigenetic Controls of CYP11B2 and CYP11B1 Gene in Subclinical Cushing Syndrome Associated with Overproduction of Aldosterone　Mitsuhiro Kometani,Masashi Demura,Takashi Yoneda,Shigehiro Karashima,Masashi Oe,Yoshiyu Takeda　ENDOCRINE REVIEWS　35　3　2014/06
  • 　Steroidogenic Enzyme Gene Expression in the Pheochromocytoma　Shigehiro Karashima,Takashi Yoneda,Masashi Demura,Mitsuhiro Kometani,Masashi Ohe,Yoshiyu Takeda　ENDOCRINE REVIEWS　35　3　2014/06
  • 　Epigenetic Control of 11 beta-Hydroxysteroid Dehydrogenase 1 in the Adipose Tissue of Cushing's Syndrome　Yoshiyu Takeda,Takashi Yoneda,Masashi Demura,Shigehiro Karashima,Mitsuhiro Kometani,Fen Wang,Yuan Cheng,Masashi Ohe　ENDOCRINE REVIEWS　35　3　2014/06
  • 　A Case of Multiple Aldosterone-Producing Microadenomas with Different Mutations in KCNJ5 Gene　Eriko Kabata,Mitsuhiro Kometani,Masashi Oe,Shigehiro Karashima,Masashi Demura,Takashi Yoneda,Yoshiyu Takeda　ENDOCRINE REVIEWS　35　3　2014/06
  • 　Diagnostic Discrepancy Between Adrenal Vein Sampling with and without ACTH Stimulation in Surgically-Curable Primary Aldosteronism Associated with KCNJ5 Somatic Mutation　Takashi Yoneda,Mitsuhiro Kometani,Masashi Demura,Shigehiro Karashima,Masashi Oe,Toshitaka Sawamura,Mitsugu Yoneda,Masakazu Yamagishi,Yoshiyu Takeda　ENDOCRINE REVIEWS　35　3　2014/06
  • 　A Case of Aldosterone-Producing Microadenoma with KCNJ5 Mutation　Masashi Oe,Mitsuhiro Kometani,Shigehiro Karashima,Masashi Demura,Takashi Yoneda,Yoshiyu Takeda　ENDOCRINE REVIEWS　35　3　2014/06
  • 　Dynamic CCAAT/Enhancer Binding Protein-Associated Changes of DNA Methylation in the Angiotensinogen Gene　Fen Wang,Masashi Demura,Yuan Cheng,Aoshuang Zhu,Shigehiro Karashima,Takashi Yoneda,Yoshiki Demura,Yuji Maeda,Mikio Namiki,Katsuhiko Ono,Yasuhiro Nakamura,Hironobu Sasano,Tadayuki Akagi,Masakazu Yamagishi,Kiyofumi Saijoh,Yoshiyu Takeda　HYPERTENSION　63　2　281　2014/02
  • 　Multiple noncoding exons 1 of nuclear receptors NR4A family (nerve growth factor-induced clone B, Nur-related factor 1 and neuron-derived orphan receptor 1) and NR5A1 (steroidogenic factor 1) in human cardiovascular and adrenal tissues　Masashi Demura,Fen Wang,Takashi Yoneda,Shigehiro Karashima,Shunsuke Mori,Masashi Oe,Mitsuhiro Kometani,Toshitaka Sawamura,Yuan Cheng,Yuji Maeda,Mikio Namiki,Hidekazu Ino,Noboru Fujino,Katsuharu Uchiyama,Toshinari Tsubokawa,Masakazu Yamagishi,Yasuhiro Nakamura,Katsuhiko Ono,Hironobu Sasano,Yoshiki Demura,Yoshiyu Takeda　JOURNAL OF HYPERTENSION　29　6　1185　2011/06
  • 　Angiotensin II receptor blocker combined with eplerenone or hydrochlorothiazide for hypertensive patients with diabetes mellitus　Shigehiro Karashima,Takashi Yoneda,Mitsuhiro Kometani,Masashi Ohe,Shunsuke Mori,Toshitaka Sawamura,Kenji Furukawa,Masakazu Yamagishi,Yoshiyu Takeda　CLINICAL AND EXPERIMENTAL HYPERTENSION　38　7　565　2016
  • 　Impact of aldosterone-producing cell clusters on diagnostic discrepancies in primary aldosteronism.　Mitsuhiro Kometani,Takashi Yoneda,Daisuke Aono,Shigehiro Karashima,Masashi Demura,Koshiro Nishimoto,Masakazu Yamagishi,Yoshiyu Takeda　Oncotarget　9　40　26007　2018/05/25
  • 　Epigenetic Regulation of Aldosterone Synthase Gene by Sodium and Angiotensin II.　Yoshimichi Takeda,Masashi Demura,Fen Wang,Shigehiro Karashima,Takashi Yoneda,Mitsuhiro Kometani,Atsushi Hashimoto,Daisuke Aono,Shin-Ichi Horike,Makiko Meguro-Horike,Masakazu Yamagishi,Yoshiyu Takeda　Journal of the American Heart Association　7　10　2018/05/08
  • 　Prevalence of primary aldosteronism without hypertension in the general population: Results in Shika study.　Shigehiro Karashima,Mitsuhiro Kometani,Hiromasa Tsujiguchi,Hiroki Asakura,Shigeru Nakano,Mikiya Usukura,Shunsuke Mori,Masashi Ohe,Toshitaka Sawamura,Rika Okuda,Akinori Hara,Toshinari Takamura,Masakazu Yamagishi,Hiroyuki Nakamura,Yoshiyu Takeda,Takashi Yoneda　Clinical and experimental hypertension (New York, N.Y. : 1993)　40　2　118　2018
  • 　Effect of sodium glucose cotransporter 2 inhibitors on obstructive sleep apnea in patients with type 2 diabetes　Kei Sawada,Shigehiro Karashima,Mitsuhiro Kometani,Rie Oka,Yoshimichi Takeda,Toshitaka Sawamura,Aya Fujimoto,Masashi Demura,Ayako Wakayama,Mikiya Usukura,Kunimasa Yagi,Yoshiyu Takeda,Takashi Yoneda　Endocrine Journal　65　4　461　2018
  • 　Associations between Sleep-Disordered Breathing and Metabolic Risk Factors beyond Obesity.　Wakabayashi Y,Oka R,Nakaya M,Karashima S,Kometani M,Sakurai M,Yoshimura K,Yoneda T　Journal of diabetes research　2018　1567683　2018
  • 　Cortisol overproduction results from DNA methylation of CYP11B1 in hypercortisolemia　Mitsuhiro Kometani,Takashi Yoneda,Masashi Demura,Hiroshi Koide,Koshiro Nishimoto,Kuniaki Mukai,Celso E. Gomez-Sanchez,Tadayuki Akagi,Takashi Yokota,Shin-ichi Horike,Shigehiro Karashima,Isamu Miyamori,Masakazu Yamagishi,Yoshiyu Takeda　SCIENTIFIC REPORTS　7　1　11205　2017/09
  • 　A Novel Method: Super-selective Adrenal Venous Sampling　Kohzoh Makita,Koshiro Nishimoto,Kanako Kiriyama-Kitamoto,Shigehiro Karashima,Tsugio Seki,Masanori Yasuda,Seishi Matsui,Masao Omura,Tetsuo Nishikawa　JOVE-JOURNAL OF VISUALIZED EXPERIMENTS　127　2017/09
  • 　Mutated KCNJ5 activates the acute and chronic regulatory steps in aldosterone production　Namita G. Hattangady,Shigehiro Karashima,Lucy Yuan,Daniela Ponce-Balbuena,Jose Jalife,Celso E. Gomez-Sanchez,Richard J. Auchus,William E. Rainey,Tobias Else　JOURNAL OF MOLECULAR ENDOCRINOLOGY　57　1　1　2016/07
  • 　Comparison of eplerenone and spironolactone for the treatment of primary aldosteronism　Shigehiro Karashima,Takashi Yoneda,Mitsuhiro Kometani,Masashi Ohe,Shunsuke Mori,Toshitaka Sawamura,Kenji Furukawa,Takashi Seta,Masakazu Yamagishi,Yoshiyu Takeda　HYPERTENSION RESEARCH　39　3　133　2016/03
  • 　Madelung disease in a 58-year-old man.　Karashima S,Yoneda T　CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne　191　2　E48　2019/01
  • 　Pheochromocytoma crisis with cyclic fluctuation in blood pressure mimics acute coronary syndrome　Mitsuhiro Kometani,Takashi Yoneda,Yuji Maeda,Masashi Oe,Yoshimichi Takeda,Takuya Higashitani,Daisuke Aono,Asuka Yoshino,Shigehiro Karashima,Yoshiyu Takeda　Endocrinology, Diabetes & Metabolism Case Reports　2020　2020/09/23　
  • 　Feasibility of a Novel Mobile C-Reactive Protein–Testing Device Using Gold-Linked Electrochemical Immunoassay: Clinical Performance Study　Yuko Gondoh-Noda,Mitsuhiro Kometani,Akihiro Nomura,Daisuke Aono,Shigehiro Karashima,Hiromi Ushijima,Eiichi Tamiya,Toshinori Murayama,Takashi Yoneda　JMIR mHealth and uHealth　8　9　e18782　2020/09/07
  • 　A case of renovascular hypertension with incidental primary bilateral macronodular adrenocortical hyperplasia　Takuya Higashitani,Shigehiro Karashima,Daisuke Aono,Seigoh Konishi,Mitsuhiro Kometani,Rie Oka,Masashi Demura,Kenji Furukawa,Yuto Yamazaki,Hironobu Sasano,Takashi Yoneda,Yoshiyu Takeda　Endocrinology, Diabetes & Metabolism Case Reports　2020　1　1　2020/08/06　
  • 　Impact of mineralocorticoid receptor blockade with direct renin inhibition in angiotensin II-dependent hypertensive mice　Atsushi Hashimoto,Yoshimichi Takeda,Shigehiro Karashima,Mitsuhiro Kometani,Daisuke Aono,Masashi Demura,Takuya Higashitani,Seigo Konishi,Takashi Yoneda,Yoshiyu Takeda　Hypertension Research　43　10　1099　2020/05　
  • 　Genetic and epigenetic analyses of aldosterone-producing adenoma with hypercortisolemia　Mitsuhiro Kometani,Takashi Yoneda,Masashi Demura,Daisuke Aono,Yuko Gondoh,Shigehiro Karashima,Koshiro Nishimoto,Masanori Yasuda,Shin-ichi Horike,Yoshiyu Takeda　Steroids　151　108470　2019/11
  • 　Impact of Gut Microbiome on Hypertensive Patients With Low-Salt Intake: Shika Study Results　Satoshi Nagase,Shigehiro Karashima,Hiromasa Tsujiguchi,Hirohito Tsuboi,Sakae Miyagi,Mitsuhiro Kometani,Daisuke Aono,Takuya Higashitani,Masashi Demura,Hiroyuki Sakakibara,Akihiro Yoshida,Akinori Hara,Hiroyuki Nakamura,Yoshiyu Takeda,Hidetaka Nambo,Takashi Yoneda,Shigefumi Okamoto　Frontiers in Medicine　7　475　2020/09/02　
  • 　Effect of sodium–glucose cotransporter-2 inhibitors on aldosterone-to-renin ratio in diabetic patients with hypertension: a retrospective observational study　Toshitaka Sawamura,Shigehiro Karashima,Satoshi Nagase,Hidetaka Nambo,Eiko Shimizu,Takuya Higashitani,Daisuke Aono,Azusa Ohbatake,Mitsuhiro Kometani,Masashi Demura,Kenji Furukawa,Yoshiyu Takeda,Takashi Yoneda　BMC Endocrine Disorders　20　1　177　2020/12　
  • 　Primary aldosteronism subtype discordance between computed tomography and adrenal venous sampling　Daisuke Aono,Mitsuhiro Kometani,Shigehiro Karashima,Mikiya Usukura,Yuko Gondo,Atsushi Hashimoto,Masashi Demura,Kenji Furukawa,Yoshiyu Takeda,Masaaki Kawashiri,Takashi Yoneda　Hypertension Research　42　12　1942　2019/12　
  • 　C-Peptide Area Under the Curve at Glucagon Stimulation Test Predicts Glucose Improvements by GLP-1 Receptor Analogue: A Retrospective Observational Study　Azusa Ohbatake,Kunimasa Yagi,Shigehiro Karashima,Yuki Shima,Yukiko Miyamoto,Hiroyuki Asaka,Satoko Okazaki,Mitsuhiro Kometani,Masa-aki Kawashiri,Yoshiyu Takeda,Takashi Yoneda,Daisuke Chujo　Diabetes Therapy　10　2　673　2019/04　
  • 　Renal Artery Aneurysm Due to Fenestration of a Branch of the Renal Artery: A Case Study　Shigehiro Karashima,Mitsuhiro Kometani,Daisuke Aono,Takuya Higashitani,Yuya Nishimoto,Seigoh Konishi,Masashi Demura,Yoshiyu Takeda,Takashi Yoneda　Journal of the Endocrine Society　5　2　2021/02/01　
  • 　Primary Aldosteronism with Parathyroid Hormone Elevation: A Single-center Retrospective Study.　Mitsuhiro Kometani,Takashi Yoneda,Daisuke Aono,Yuko Gondoh-Noda,Takahiro Matsuoka,Takuya Higashitani,Shohei Yoshikura,Kei Sawada,Yoshimichi Takeda,Aya Fujimoto,Shigehiro Karashima,Mikiya Usukura,Yoshiyu Takeda　Internal medicine (Tokyo, Japan)　60　7　993　2021
  • 　Penile and scrotal oedema along with urinary retention after insulin therapy.　Yoshimichi Takeda,Shigehiro Karashima,Mitsuhiro Kometani,Takashi Yoneda　BMJ case reports　14　7　2021/07/22
  • 　Effect of potassium on DNA methylation of aldosterone synthase gene.　Yoshimichi Takeda,Masashi Demura,Fen Wang,Shigehiro Karashima,Takashi Yoneda,Mitsuhiro Kometani,Daisuke Aomo,Atsushi Hashimoto,Shin-Ichi Horike,Makiko Meguro-Horike,Yoshiyu Takeda　Journal of hypertension　39　5　1018　2021/05/01
  • 　Carcinoma of unknown primary origin with isolated adrenal metastasis: a report of two cases.　Mitsuhiro Kometani,Takashi Yoneda,Yuji Maeda,Koushiro Ohtsubo,Yuto Yamazaki,Hiroko Ikeda,Shunsuke Mori,Daisuke Aono,Shigehiro Karashima,Mikiya Usukura,Hironobu Sasano,Yoshiyu Takeda　Endocrine journal　68　10　1209　2021/10/28
  • 　Impact of salt intake on urinary albumin excretion in patients with type 2 diabetic nephropathy: a retrospective cohort study based on a generalized additive model.　Yuka Kotake,Shigehiro Karashima,Masaki Kawakami,Satoshi Hara,Daisuke Aono,Seigo Konishi,Mitsuhiro Kometani,Hiroyuki Mori,Yoshiyu Takeda,Takashi Yoneda,Hidetaka Nambo,Kenji Furukawa　Endocrine journal　69　5　577　2021/12/22
  • 　Explainable Machine Learning for Atrial Fibrillation in the General Population Using a Generalized Additive Model - A Cross-Sectional Study.　Masaki Kawakami,Shigehiro Karashima,Kento Morita,Hayato Tada,Hirofumi Okada,Daisuke Aono,Mitsuhiro Kometani,Akihiro Nomura,Masashi Demura,Kenji Furukawa,Takashi Yoneda,Hidetaka Nambo,Masa-Aki Kawashiri　Circulation reports　4　2　73　2022/02/10
  • 　Rapidity and Precision of Steroid Hormone Measurement.　Shigehiro Karashima,Issey Osaka　Journal of clinical medicine　11　4　2022/02/12
  • 　Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome Worsen after the Administration of Dulaglutide.　Toshitaka Sawamura,Shigehiro Karashima,Ai Ohmori,Kei Sawada,Mitsuhiro Kometani,Yoshiyu Takeda,Takashi Yoneda　Medicina (Kaunas, Lithuania)　58　2　2022/02/14
  • 　Evaluating tubulointerstitial compartments in renal biopsy specimens using a deep learning-based approach for classifying normal and abnormal tubules.　Satoshi Hara,Emi Haneda,Masaki Kawakami,Kento Morita,Ryo Nishioka,Takeshi Zoshima,Mitsuhiro Kometani,Takashi Yoneda,Mitsuhiro Kawano,Shigehiro Karashima,Hidetaka Nambo　PloS one　17　7　e0271161　2022
  • 　Impact of gut microbiome on dyslipidemia in japanese adults: Assessment of the Shika-machi super preventive health examination results for causal inference.　Yuna Miyajima,Shigehiro Karashima,Kazuhiro Ogai,Kouki Taniguchi,Kohei Ogura,Masaki Kawakami,Hidetaka Nambo,Mitsuhiro Kometani,Daisuke Aono,Masashi Demura,Takashi Yoneda,Hiromasa Tsujiguchi,Akinori Hara,Hiroyuki Nakamura,Shigefumi Okamoto　Frontiers in cellular and infection microbiology　12　908997　2022
  • 　Hiccups as the first presentation of secondary adrenal insufficiency associated with advanced cervical cancer.　Toshitaka Sawamura,Shigehiro Karashima,Ai Ohmori,Kei Sawada,Daisuke Aono,Mitsuhiro Kometani,Yoshiyu Takeda,Takashi Yoneda　Endocrinology, diabetes & metabolism case reports　2022　2022/08/01
  • 　Effect of Intraprocedural Cortisol Measurement on ACTH-stimulated Adrenal Vein Sampling in Primary Aldosteronism.　Mitsuhiro Kometani,Takashi Yoneda,Shigehiro Karashima,Yoshiyu Takeda,Mika Tsuiki,Akihiro Yasoda,Isao Kurihara,Norio Wada,Takuyuki Katabami,Masakatsu Sone,Takamasa Ichijo,Kouichi Tamura,Yoshihiro Ogawa,Hiroki Kobayashi,Shintaro Okamura,Nobuya Inagaki,Junji Kawashima,Megumi Fujita,Kenji Oki,Yuichi Matsuda,Akiyo Tanabe,Mitsuhide Naruse　Journal of the Endocrine Society　6　9　bvac104　2022/09/01
  • 　In vivo relationship between bound and free insulin in patients with diabetes having anti-insulin antibodies　Hiroyuki Asaka,Shigehiro Karashima,Daisuke Chujo,Mitsuhiro Kometani,Mikiya Usukura,Kunimasa Yagi,Ko Aiga,Takashi Yoneda　Diabetology International　2023
  • 　Impact of conducting adrenal venous sampling in the morning versus afternoon in primary aldosteronism　Mau Yoneda,Mitsuhiro Kometani,Ko Aiga,Shigehiro Karashima,Mikiya Usukura,Shunsuke Mori,Yoshimichi Takeda,Daisuke Aono,Seigo Konishi,Kenichiro Okumura,Takahiro Ogi,Satoshi Kobayashi,Yoshiyu Takeda,Takashi Yoneda　Journal of the Endocrine Society　2023/01/14　
  • 　A hyperaldosteronism subtypes predictive model using ensemble learning.　Shigehiro Karashima,Masaki Kawakami,Hidetaka Nambo,Mitsuhiro Kometani,Isao Kurihara,Takamasa Ichijo,Takuyuki Katabami,Mika Tsuiki,Norio Wada,Kenji Oki,Yoshihiro Ogawa,Ryuji Okamoto,Kouichi Tamura,Nobuya Inagaki,Takanobu Yoshimoto,Hiroki Kobayashi,Miki Kakutani,Megumi Fujita,Shoichiro Izawa,Tetsuya Suwa,Kohei Kamemura,Masanobu Yamada,Akiyo Tanabe,Mitsuhide Naruse,Takashi Yoneda　Scientific reports　13　1　3043　2023/02/21
  • 　Molecular and Epigenetic Control of Aldosterone Synthase, CYP11B2 and 11-Hydroxylase, CYP11B1.　Yoshimichi Takeda,Masashi Demura,Mitsuhiro Kometani,Shigehiro Karashima,Takashi Yoneda,Yoshiyu Takeda　International journal of molecular sciences　24　6　2023/03/17
  • 　Impact of gut microbiome on the renin-aldosterone system: Shika-machi Super Preventive Health Examination results.　Ren Mizoguchi,Shigehiro Karashima,Yuna Miyajima,Kohei Ogura,Mitsuhiro Kometani,Daisuke Aono,Seigo Konishi,Masashi Demura,Hiromasa Tsujiguchi,Akinori Hara,Hiroyuki Nakamura,Takashi Yoneda,Shigefumi Okamoto,Kenji Satou　Hypertension research : official journal of the Japanese Society of Hypertension　2023/06/06
  • 　Impact of gut microbiome on serum IgG4 levels in the general population: Shika-machi super preventive health examination results　Aoi Koshida,Shigehiro Karashima,Kohei Ogura,Yuna Miyajima,Kazuhiro Ogai,Ren Mizoguchi,Yasuo Ikagawa,Satoshi Hara,Ichiro Mizushima,Hiroshi Fujii,Mitsuhiro Kawano,Hiromasa Tsujiguchi,Akinori Hara,Hiroyuki Nakamura,Shigefumi Okamoto　Frontiers in Cellular and Infection Microbiology　13　2023/10/16　
  • 　Comprehensive Steroid Assay with Non-Targeted Analysis Using Liquid Chromatography Ion Mobility Mass Spectrometry　Mai Yamakawa,Shigehiro Karashima,Riko Takata,Taichi Haba,Keigo Kuroiwa,Hideaki Touyama,Atsushi Hashimoto,Seigo Konishi,Daisuke Aono,Mitsuhiro Kometani,Hidetaka Nambo,Takashi Yoneda,Issey Osaka　International Journal of Molecular Sciences　23　22　13858　2022/11/10　
  • 　A case of adrenocortical carcinoma diagnosed 9 years after the discovery of adrenal incidentaloma.　Daisuke Aono,Mitsuhiro Kometani,Takahiro Asano,Seigo Konishi,Shigehiro Karashima,Hiroko Ikeda,Takahiro Nohara,Takashi Yoneda　Endocrine journal　2022/08/06

Conference Presentations

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

○Development of explainable disease prediction algorithms using medical big data
○Quantification and Imaging of Steroid Using Mass Spectrometry

Grant-in-Aid for Scientific Research

○「イオンモビリティ質量分析法を用いた毛髪メタボロミクスによる健康・疾患予測」(2023-2025)　
○「腸内細菌叢相互ネットワークを標的にした生活習慣病改善フレームワークの開発」(2022-2024)　
○「腸内細菌由来ステロイドホルモンによる塩感受性代謝制御ネットワークの解明」(2021-2024)　
○「オンライン特定保健指導・オンライン診療におけるPHR活用による行動変容に関する研究」(2020-2023)　
○「副腎皮質ホルモン由来の生活習慣病の早期診断法の開発と疾患原理の追及 」(2019-2021)　
○「ステロイドメタボロミクス解析による生活習慣病発症バイオマーカーの探索的研究」(2019-2020)　
○「原発性アルドステロン症の罹病率と遺伝子学 的背景及びステロイドプロファイルの検討 」(2017-2019)　

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Regulatory Science(2023)
○Introduction to Technology(2023)
○Reform of Medical System and Medical Economics(2023)
○Health Promotion of the Future(2023)
○Practice of Wellness Promotion(2023)
○Practice of Wellness Promotion(2023)
○Introduction to Technology(2022)
○Practice of Wellness Promotion(2022)
○Introduction to Technology(2021)
○Academic Skills(2021)
○Health Science (2020)
○Health Promotion of the Future(2020)
○Health Promotion of the Future(2020)
○Health Promotion of the Future(2020)

Classes (Graduate Schools)

International Project

International Students

Lecture themes

Others (Social Activities)

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