last modified：2025/04/08
Professor WADA Taizo
Faculty, Affiliation
Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences
College and School Educational Field
Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
Laboratory
TEL:076-265-2313 FAX:076-262-1866
Academic Background
【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor Graduate School, Division of Medicine 199703 Completed
【Academic background(Bachelor's Degree)】
Kanazawa University 199203
【Degree】
PhD
Career
1999-2002 National Institutes of Health Visiting Fellow
Year & Month of Birth
Academic Society
Award
○JSPS Research Fellowships for Japanese Biomedical and Behavioral Researchers at NIH(2001/01)
○2002 Fellows Award for Research Excellence (NIH)(2002)
○Juzen Medical Award(2008/11)
○Juzen Medical Award(2008/11)
○Juzen Medical Award(2008/11)
Specialities
Speciality Keywords
pediatrics, clinical immunology
Research Themes
Ontogeny of immune system and its abnormality
Pathogenesis of EBV-associated lymphoproliferative diseases
Books
Papers
- Hematopoietic stem cell transplantation for progressive combined immunodeficiency and lymphoproliferation in patients with activated phosphatidylinositol-3-OH kinase δ syndrome type 1. Tsubasa Okano,Kohsuke Imai,Yuki Tsujita,Noriko Mitsuiki,Kenichi Yoshida,Chikako Kamae,Kenichi Honma,Kanako Mitsui-Sekinaka,Yujin Sekinaka,Tamaki Kato,Katsuyuki Hanabusa,Eri Endo,Takehiro Takashima,Haruka Hiroki,Tzu-Wen Yeh,Keisuke Tanaka,Masakazu Nagahori,Ikuya Tsuge,Yuki Bando,Fuminori Iwasaki,Yoshiaki Shikama,Masami Inoue,Tomiko Kimoto,Naohiko Moriguchi,Yuki Yuza,Takashi Kaneko,Kyoko Suzuki,Tomoyo Matsubara,Yoshihiro Maruo,Tomoaki Kunitsu,Tomoko Waragai,Hideki Sano,Yuko Hashimoto,Kazuhiro Tasaki,Osamu Suzuki,Toshihiko Shirakawa,Motohiro Kato,Toru Uchiyama,Masataka Ishimura,Tetsuzo Tauchi,Hiroshi Yagasaki,Shiann-Tarng Jou,Hsin-Hui Yu,Hirokazu Kanegane,Sven Kracker,Anne Durandy,Daiei Kojima,Hideki Muramatsu,Taizo Wada,Yuzaburo Inoue,Hidetoshi Takada,Seiji Kojima,Seishi Ogawa,Osamu Ohara,Shigeaki Nonoyama,Tomohiro Morio The Journal of allergy and clinical immunology 143 1 266 2019/01
- C/EBPε ΔRS derived from a neutrophil-specific granule deficiency patient interacts with HDAC1 and its dysfunction is restored by trichostatin A. Muraoka M,Akagi T,Ueda A,Wada T,Koeffler HP,Yokota T,Yachie A Biochemical and biophysical research communications 516 1 293 2019/08
- Collagen adhesion gene is associated with bloodstream infections caused by methicillin-resistant Staphylococcus aureus. Yasunori Iwata,Kenji Satou,Kengo Furuichi,Ikuko Yoneda,Takuhiro Matsumura,Masahiro Yutani,Yukako Fujinaga,Atsushi Hase,Hidetoshi Morita,Toshiko Ohta,Yasuko Senda,Yukiko Sakai-Takemori,Taizo Wada,Shinichi Fujita,Taito Miyake,Haruka Yasuda,Norihiko Sakai,Shinji Kitajima,Tadashi Toyama,Yasuyuki Shinozaki,Akihiro Sagara,Taro Miyagawa,Akinori Hara,Miho Shimizu,Yasutaka Kamikawa,Kazuho Ikeo,Shigeyuki Shichino,Satoshi Ueha,Takuya Nakajima,Kouji Matsushima,Shuichi Kaneko,Takashi Wada International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 91 22 2020/02
- Downregulation of CD5 and dysregulated CD8+ T-cell activation. Wada T Pediatrics international : official journal of the Japan Pediatric Society 60 9 776 2018/09
- XL-EDA-ID Presenting with Congenital Duodenal Atresia and Perforations. Mitani Y,Wada T,Matsuda Y,Sakai S,Yachie A Journal of clinical immunology 38 7 733 2018/08
- Novel HAX1 Gene Mutation in a Vietnamese Boy with Severe Congenital Neutropenia. Tran TT,Vu QV,Wada T,Yachie A,Le Thi Minh H,Nguyen SN Case reports in pediatrics 2018 2798621 2018
- Enhanced AKT Phosphorylation of Circulating B Cells in Patients With Activated PI3Kδ Syndrome. Takaki Asano,Satoshi Okada,Miyuki Tsumura,Tzu-Wen Yeh,Kanako Mitsui-Sekinaka,Yuki Tsujita,Youjiro Ichinose,Akira Shimada,Kunio Hashimoto,Taizo Wada,Kohsuke Imai,Osamu Ohara,Tomohiro Morio,Shigeaki Nonoyama,Masao Kobayashi Frontiers in immunology 9 568 2018
- Flow cytometry-based diagnosis of primary immunodeficiency diseases Hirokazu Kanegane,Akihiro Hoshino,Tsubasa Okano,Takahiro Yasumi,Taizo Wada,Hidetoshi Takada,Satoshi Okada,Motoi Yamashita,Tzu-wen Yeh,Ryuta Nishikomori,Masatoshi Takagi,Kohsuke Imai,Hans D. Ochs,Tomohiro Morio Allergology International 67 1 43 2018/01/01
- Characterization of skin blister fluids from children with Epstein–Barr virus-associated lymphoproliferative disease Taizo Wada,Tomoko Toma,Hanae Miyazawa,Eiko Koizumi,Tetsujiro Shirahashi,Yusuke Matsuda,Akihiro Yachie Journal of Dermatology 45 4 444 2018/04/01
- Longitudinal analysis of serum interleukin-18 in patients with familial Mediterranean fever carrying MEFV mutations in exon 10 Taizo Wada,Tomoko Toma,Hanae Miyazawa,Eiko Koizumi,Tetsujiro Shirahashi,Yusuke Matsuda,Akihiro Yachie Cytokine 104 143 2018/04/01
- Human CTL-based functional analysis shows the reliability of a munc13-4 protein expression assay for FHL3 diagnosis. Hirofumi Shibata,Takahiro Yasumi,Saeko Shimodera,Eitaro Hiejima,Kazushi Izawa,Tomoki Kawai,Ryutaro Shirakawa,Taizo Wada,Ryuta Nishikomori,Hisanori Horiuchi,Osamu Ohara,Eiichi Ishii,Toshio Heike Blood 131 18 2016 2018/05/03
- The increased frequency of methicillin-resistant Staphylococcus aureus with low MIC of beta-lactam antibiotics isolated from hospitalized patients. Yasunori Iwata,Norihiko Sakai,Ikuko Yoneda,Kenji Satou,Kengo Furuichi,Yasuko Senda,Yukiko Sakai-Takemori,Taizo Wada,Shinichi Fujita,Hisahiro Ogura,Kouichi Sato,Taichiro Minami,Kaori Yamaguchi,Shinji Kitajima,Tadashi Toyama,Yuta Yamamura,Taro Miyagawa,Akinori Hara,Miho Shimizu,Yoshio Sakai,Kazuho Ikeo,Shigeyuki Shichino,Satoshi Ueha,Takuya Nakajima,Kouji Matsushima,Takashi Wada Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 26 6 604 2020/06
- Apoptosis inhibitor of macrophage as a biomarker for disease activity in Japanese children with IgA nephropathy and Henoch-Schönlein purpura nephritis. Hitoshi Irabu,Masaki Shimizu,Shuya Kaneko,Natsumi Inoue,Mao Mizuta,Yuko Tasaki,Kazuhide Ohta,Akihiro Yachie,Taizo Wada Pediatric research 89 3 667 2020/05/14
- High-throughput analysis revealed the unique immunoglobulin gene rearrangements in plasmacytoma-like post-transplant lymphoproliferative disorder. Akihiro Hoshino,Akira Nishimura,Takuya Naruto,Tsubasa Okano,Kazuaki Matsumoto,Keisuke Okamoto,Hiroshi Shintaku,Shown Tokoro,Hiroyuki Okamoto,Taizo Wada,Masatoshi Takagi,Kohsuke Imai,Hirokazu Kanegane,Tomohiro Morio British journal of haematology 189 4 e164-e168 2020/05
- Hematopoietic stem cell transplantation for progressive combined immunodeficiency and lymphoproliferation in patients with activated phosphatidylinositol-3-OH kinase δ syndrome type 1. Okano T, Imai K, Tsujita Y, Mitsuiki N, Yoshida K, Kamae C, Honma K, Mitsui-Sekinaka K, Sekinaka Y, Kato T, Hanabusa K, Endo E, Takashima T, Hiroki H, Yeh TW, Tanaka K, Nagahori M, Tsuge I, Bando Y, Iwasaki F, Shikama Y, Inoue M, Kimoto T, Moriguchi N, Yuza Y, Kaneko T, Suzuki K, Matsubara T, Maruo Y, Kunitsu T, Waragai T, Sano H, Hashimoto Y, Tasaki K, Suzuki O, Shirakawa T, Kato M, Uchiyama T, Ishimura M, Tauchi T, Yagasaki H, Jou ST, Yu HH, Kanegane H, Kracker S, Durandy A, Kojima D, Muramatsu H, Wada T, Inoue Y, Takada H, Kojima S, Ogawa S, Ohara O, Nonoyama S, Morio T. J Allergy Clin Immunol 143 1 266-275 2019/01
- Novel HAX1 Gene Mutation in a Vietnamese Boy with Severe Congenital Neutropenia. Tran TT, Vu QV, Wada T, Yachie A, Le Thi Minh H, Nguyen SN. Case Rep Pediatr 2798621 2018
- XL-EDA-ID Presenting with Congenital Duodenal Atresia and Perforations. Mitani Y, Wada T, Matsuda Y, Sakai S, Yachie A. J Clin Immunol 38 7 733-735 2018
- Downregulation of CD5 and dysregulated CD8+ T-cell activation. Wada T. Pediatr Int 60 9 776-780 2018
- Human CTL-based functional analysis shows the reliability of a munc13-4 protein expression assay for FHL3 diagnosis. Shibata H, Yasumi T, Shimodera S, Hiejima E, Izawa K, Kawai T, Shirakawa R, Wada T, Nishikomori R, Horiuchi H, Ohara O, Ishii E, Heike T. Blood 131 18 2016-2025 2018
- Enhanced AKT Phosphorylation of Circulating B Cells in Patients With Activated PI3Kδ Syndrome. Asano T, Okada S, Tsumura M, Yeh TW, Mitsui-Sekinaka K, Tsujita Y, Ichinose Y, Shimada A, Hashimoto K, Wada T, Imai K, Ohara O, Morio T, Nonoyama S, Kobayashi M. Front Immunol 9 568 2018
- Characterization of skin blister fluids from children with Epstein-Barr virus-associated lymphoproliferative disease. Wada T, Toma T, Miyazawa H, Koizumi E, Shirahashi T, Matsuda Y, Yachie A. J Dermatol 45 4 444-449 2018
- Longitudinal analysis of serum interleukin-18 in patients with familial Mediterranean fever carrying MEFV mutations in exon 10. Wada T, Toma T, Miyazawa H, Koizumi E, Shirahashi T, Matsuda Y, Yachie A. Cytokine 104 143-146 2018
- Flow cytometry-based diagnosis of primary immunodeficiency diseases. Kanegane H, Hoshino A, Okano T, Yasumi T, Wada T, Takada H, Okada S, Yamashita M, Yeh TW, Nishikomori R, Takagi M, Imai K, Ochs HD, Morio T. Allergol Int 67 1 43-54 2018/01
- The down-regulation of two component system and cell wall biosynthesis related genes was associated with the reversion to daptomycin (DAP) susceptibility in DAP non-susceptible methicillin-resistant Staphylococcus aureus. Iwata Y, Satou K, Tsuzuku H, Furuichi K, Senda Y, Sakai-Takemori Y, Wada T, Fujita S, Miyake T, Yasuda H, Sakai N, Kitajima S, Toyama T, Shinozaki Y, Sagara A, Miyagawa T, Hara A, Shimizu M, Kamikawa Y, Kaneko S, Wada T. Eur J Clin Microbiol Infect Dis 36 10 1839-1845 2017/10
- Peripheral blood plasmacytosis in severe fever with thrombocytopenia syndrome. Wada T, Iwata Y, Kamikawa Y, Wada T, Yachie A. Jpn J Infect Dis 70 4 470-471 2017
- Prolonged neutropenia due to antihuman neutrophil antigen 2 (CD177) antibody after bone marrow transplantation. Wada T, Miyamoto S, Okamoto H, Matsuda Y, Toma T, Imai K, Takagi M, Morio T, Yachie A. Pediatr Blood Cancer 64 7 e26388 2017
- Role of the Leucine Zipper Domain of CCAAT/Enhancer Binding Protein-Epsilon (C/EBPε) in Neutrophil-Specific Granule Deficiency Wada T, Akagi T. Crit Rev Immunol 36 4 349-358 2016/12
- Elevation of fecal eosinophil-derived neurotoxin in infants with food protein-induced enterocolitis syndrome. Wada T, Toma T, Muraoka M, Matsuda Y, Yachie A. Pediatr Allergy Immunol 25 6 617-619 2014/10
- Munc13-4 deficiency with CD5 downregulation on activated CD8+ T cells. Wada T, Yasumi T, Toma T, Hori M, Maeda S, Umeda K, Heike T, Adachi S, Usami I, Yachie A. Pediatr Int 56 4 605-608 2014/08
- Fecal eosinophil-derived neurotoxin in cow's milk-sensitive enteropathy: a case report. Wada T, Matsuda Y, Muraoka M, Toma T, Yachie A. Allergol Int 64 1 99-100 2015/01
- Severe congenital neutropenia caused by the ELANE gene mutation in a Vietnamese boy with misdiagnosis of tuberculosis and autoimmune neutropenia: a case report. Vu QV, Wada T, Tran TT, Ngo DN, Van Dinh T, Nguyen CH, Le HT, Yachie A, Nguyen SN. BMC Hematol 15 2 2015/01
- Basophil activation by mosquito extracts in patients with hypersensitivity to mosquito bites. Sakakibara Y, Wada T, Muraoka M, Matsuda Y, Toma T, Yachie A. Cancer Sci 106 8 965-971 2015/08
- A Novel In-Frame Deletion in the Leucine Zipper Domain of C/EBPε Leads to Neutrophil-Specific Granule Deficiency. Wada T, Akagi T, Muraoka M, Toma T, Kaji K, Agematsu K, Koeffler HP, Yokota T, Yachie A. J Immunol 95 1 80-86 2015/07
- The critical role of lipopolysaccharide in the upregulation of aquaporin 4 in glial cells treated with Shiga toxin. Sugimoto N, Leu H, Inoue N, Shimizu M, Toma T, Kuroda M, Saito T, Wada T, Yachie A. J Biomed Sci 22 78 2015/09
- Late-Onset Combined Immunodeficiency with a Novel IL2RG Mutation and Probable Revertant Somatic Mosaicism. Okuno Y, Hoshino A, Muramatsu H, Kawashima N, Wang X, Yoshida K, Wada T, Gunji M, Toma T, Kato T, Shiraishi Y, Iwata A, Hori T, Kitoh T, Chiba K, Tanaka H, Sanada M, Takahashi Y, Nonoyama S, Ito M, Miyano S, Ogawa S, Kojima S, Kanegane H. J Clin Immunol 35 7 610-614 2015/10
- An assessment of the effects of ectopic gp91phox expression in XCGD iPSC-derived neutrophils. Lin HT, Masaki H, Yamaguchi T, Wada T, Yachie A, Nishimura K, Ohtaka M, Nakanishi M, Nakauchi H, Otsu M. Mol Ther Methods Clin Dev 2 15046 2015/12
- Disruption of vascular endothelial homeostasis in systemic juvenile idiopathic arthritis-associated macrophage activation syndrome: The dynamic roles of angiopoietin-1 and -2. Tasaki Y, Shimizu M, Inoue N, Mizuta M, Nakagishi Y, Wada T, Yachie A. Cytokine 80 1-6 2016/04
- Tumor necrosis factor-α modifies the effects of Shiga toxin on glial cells. Leu H, Sugimoto N, Shimizu M, Toma T, Wada T, Ohta K, Yachie A. Int Immunopharmacol 38 139-143 2016/09
- Increased CD69 Expression on Peripheral Eosinophils from Patients with Food Protein-Induced Enterocolitis Syndrome. Wada T, Matsuda Y, Toma T, Koizumi E, Okamoto H, Yachie A. Int Arch Allergy Immunol 170 3 201-205 2016
- Hematopoietic Stem Cell Transplantation for XIAP Deficiency in Japan. Ono S, Okano T, Hoshino A, Yanagimachi M, Hamamoto K, Nakazawa Y, Imamura T, Onuma M, Niizuma H, Sasahara Y, Tsujimoto H, Wada T, Kunisaki R, Takagi M, Imai K, Morio T, Kanegane H. J Clin Immunol 37 1 85-91 2017/01
- Successful treatment of idiopathic colitis related to XIAP deficiency with allo-HSCT using reduced-intensity conditioning Tsuma, Yusuke; Imamura, Toshihiko; Ichise, Eisuke; Sakamoto, Kenichi; Ouchi, Kazutaka; Osone, Shinya; Ishida, Hiroyuki; Wada, Taizo; Hosoi, Hajime Pediatric Transplantation 19 1 E25-E28 2015/01/01
- Early diagnosis of Danon disease: Flow cytometric detection of lysosome-associated membrane protein-2-negative leukocytes Hashida, Yoko; Wada, Taizo; Saito, Takekatsu; Ohta, Kunio; Kasahara, Yoshihito; Yachie, Akihiro Journal of Cardiology 2014/06/10
- Shiga toxin-2 enhances heat-shock-induced apoptotic cell death in cultured and primary glial cells Sugimoto, Naotoshi; Toma, Tomoko; Shimizu, Masaki; Kuroda, Mondo; Wada, Taizo; Yachie, Akihiro Cell Biology and Toxicology 30 5 289-299 2014/01/01
- Successful treatment of systemic cytomegalovirus infection in severe combined immunodeficiency using allogeneic bone marrow transplantation followed by adoptive immunotherapy Koura, U.; Sakaki-Nakatsubo, Hisano; Otsubo, Keisuke; Nomura, Keiko; Oshima, Koichi; Ohara, Osamu; Wada, Taizo; Yachie, Akihiro; Imai, Kohsuke; Morio, Tomohiro; Miyawaki, Toshio; Kanegane, Hirokazu Journal of Investigational Allergology and Clinical Immunology 24 3 200-202 2014/01/01
- Down-regulation of CD5 expression on activated CD8+ T cells in familial hemophagocytic lymphohistiocytosis with perforin gene mutations Wada, Taizo; Sakakibara, Yasuhisa; Nishimura, Ryosei; Toma, Tomoko; Ueno, Yasuhisa; Horita, Seiki; Tanaka, Taihei; Nishi, Masanori; Kato, Keisuke; Yasumi, Takahiro; Ohara, Osamu; Yachie, Akihiro Human Immunology 74 12 1579-1585 2013/10/11
- Expansion of a liver-infiltrating cytotoxic T-lymphocyte clone in concert with the development of hepatitis-associated aplastic anaemia Ikawa, Yasuhiro; Nishimura, Ryosei; Kuroda, Rie; Mase, Shintaro; Araki, Raita; Maeba, Hideaki; Wada, Taizo; Toma, Tomoko; Koizumi, Shoichi; Yachie, Akihiro British Journal of Haematology 161 4 599-602 2013/05/01
- Sustained elevation of serum interleukin-18 and its association with hemophagocytic lymphohistiocytosis in XIAP deficiency Wada, Taizo; Kanegane, Hirokazu; Ohta, Kazuhide; Katoh, Fumiyo; Imamura, Toshihiko; Nakazawa, Yozo; Miyashita, Ritsuko; Hara, Junichi; Hamamoto, Kazuko; Yang, Xi; Filipovich, Alexandra Hult; Marsh, Rebecca A.; Yachie, Akihiro Cytokine 65 1 74-78 2014/01/01
- Agranulocytosis after infectious mononucleosis Yokoyama, Tadafumi; Tokuhisa, Yuko; Toga, Akiko; Fujiki, Toshihiro; Sakakibara, Yasuhisa; Mase, Shintaro; Araki, Raita; Nishimura, Ryosei; Wada, Taizo; Fuseda, Tetsuya; Kato, Eiji; Yachie, Akihiro Journal of Clinical Virology 56 3 271-273 2013/03/01
- Clinical and immunophenotypic features of atypical complete DiGeorge syndrome Vu, Quangvan; Wada, Taizo; Toma, Tomoko; Tajima, Hanako; Maeda, Miho; Tanaka, Risa; Oh-Ishi, Tsutomu; Yachie, Akihiro Pediatrics International 55 1 2-6 2013/02/01
- Successful bone marrow transplantation with reduced intensity conditioning in a patient with delayed-onset adenosine deaminase deficiency Kanegane, Hirokazu; Taneichi, Hiromichi; Nomura, Keiko; Wada, Taizo; Yachie, Akihiro; Imai, Kohsuke; Ariga, Tadashi; Santisteban, Ines; Hershfield, Michael S J E; Miyawaki, Toshio Pediatric Transplantation 17 1 E29-E32 2013/02/01
- A case of acute encephalopathy with hemophagocytic lymphohistiocytosis and clonal T-cell expansion Wada, Taizo; Nishiura, Kashiku; Kuroda, Mondo; Asai, Erika; Vu, Quangvan; Toma, Tomoko; Niida, Yo; Yachie, Akihiro Brain and Development 34 5 376-379 2012/05/01
- Alu-mediated large deletion of the CDSN gene as a cause of peeling skin disease Wada, Taizo; Matsuda, Yusuke; Muraoka, Masahiro; Toma, Tomoko; Takehara, Kazuhiko; Fujimoto, Manabu; Yachie, Akihiro Clinical Genetics 86 4 383-386 2014/01/01
- Increased expression of epidermal thymic stromal lymphopoietin in inflammatory peeling skin syndrome Wada, Taizo; Toma, Tomoko; Hamaguchi, Yasuhito; Yachie, Akihiro Journal of Dermatology 41 5 448-449 2014/01/01
- Cytokine profiles in children with primary Epstein-Barr virus infection Wada, Taizo; Muraoka, Masahiro; Yokoyama, Tadafumi; Toma, Tomoko; Kanegane, Hirokazu; Yachie, Akihiro Pediatric Blood and Cancer 60 7 E46-E48 2013/07/01
- Rapid detection of intracellular p47phox and p67phox by flow cytometry; Useful screening tests for chronic granulomatous disease Wada, Taizo; Muraoka, Masahiro; Toma, Tomoko; Imai, Tsuyoshi; Shigemura, Tomonari; Agematsu, Kazunaga; Haraguchi, Kohei; Moriuchi, Hiroyuki; Oh-Ishi, Tsutomu; Kitoh, Toshiyuki; Ohara, Osamu; Morio, Tomohiro; Yachie, Akihiro Journal of Clinical Immunology 33 4 857-864 2013/05/01
- Somatic mosaicism in primary immune deficiencies. Wada T, Candotti F. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY 8 6 510-514 2008/12
- Delayed onset adenosine deaminase deficiency associated with acute disseminated encephalomyelitis. Nakaoka H, Kanegane H, Taneichi H, Miya K, Yang X, Nomura K, Takezaki S, Yamada M, Ohara O, Kamae C, Imai K, Nonoyama S, Wada T, Yachie A, Hershfield MS, Ariga T, Miyawaki T. INTERNATIONAL JOURNAL OF HEMATOLOGY 95 6 692-6 2012/06
- Phenotypic analysis in a case of hydroa vacciniforme-like eruptions associated with chronic active Epstein-Barr virus disease of γδ T cells. BRITISH JOURNAL OF DERMATOLOGY 166 1 216-8 2012/01
- Multiple reversions of an IL2RG mutation restore T cell function in an X-linked severe combined immunodeficiency patient. Kawai T,Saito M,Nishikomori R,Yasumi T,Izawa K,Murakami T,Okamoto S,Mori Y,Nakagawa N,Imai K,Nonoyama S,Wada T,Yachie A,Ohmori K,Nakahata T,Heike T JOURNAL OF CLINICAL IMMUNOLOGY 32 4 690-7 2012/08
- Characterization of Epstein-Barr virus (EBV)-infected cells in EBV-associated hemophagocytic lymphohistiocytosis in two patients with X-linked lymphoproliferative syndrome type 1 and type 2. Yang X,Wada T,Imadome K,Nishida N,Mukai T,Fujiwara M,Kawashima H,Kato F,Fujiwara S,Yachie A,Zhao X,Miyawaki T,Kanegane H HERPESVIRIDAE 3 1 1 2012/02
- Enhanced exon 2 skipping caused by c.910G>A variant and alternative splicing of MEFV genes in two independent cases of familial Mediterranean fever. Tone Y,Toma T,Toga A,Sakakibara Y,Wada T,Yabe M,Kusafuka H,Yachie A MODERN RHEUMATOLOGY 22 1 45-51 2012/02
- Clonal expansion of Epstein-Barr virus (EBV)-infected γδ T cells in patients with chronic active EBV disease and hydroa vacciniforme-like eruptions. Wada T,Toga A,Sakakibara Y,Toma T,Hasegawa M,Takehara K,Shigemura T,Agematsu K,Yachie A INTERNATIONAL JOURNAL OF HEMATOLOGY 96 4 443-9 2012/10
- Clinical and immunophenotypic features of atypical complete DiGeorge syndrome. Vu QV,Wada T,Toma T,Tajima H,Maeda M,Tanaka R,Oh-Ishi T,Yachie A PEDIATRICS INTERNATIONAL 55 1 2-6 2013/02
- Aberrant glycosylation of IgA in Wiskott-Aldrich syndrome and X-linked thrombocytopenia. Shimizu M,Kanegane H,Wada T,Motoyoshi Y,Morio T,Candotti F,Yachie A JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 131 2 587-90.e1-3 2013/02
- An interesting tetrad of asplenia, inflammation, hemolysis, and nephritis. Radhakrishnan N,Yadav SP,Sachdeva A,Wada T,Yachie A PEDIATRIC HEMATOLOGY AND ONCOLOGY 28 8 723-6 2011/11
- Gene therapy for primary immune deficiencies. Otsu M, Wada T, Candotti F CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY 1 6 497-501 2001/12
- Urinary Heme Oxygenase-1 as a Sensitive Indicator of Tubulointerstitial Inflammatory Damage in Various Renal Diseases. Yokoyama T, Shimizu M, Ohta K, Yuno T, Okajima M, Wada T, Toma T, Koizumi S, Yachie A. AMERICAN JOURNAL OF NEPHROLOGY 33 5 414-420 2011/04
- Analysis of mutations and recombination activity in RAG-deficient patients. Asai E, Wada T, Sakakibara Y, Toga A, Toma T, Shimizu T, Nampoothiri S, Imai K, Nonoyama S, Morio T, Muramatsu H, Kamachi Y, Ohara O, Yachie A. CLINICAL IMMUNOLOGY 138 2 172-177 2011/02
- Delayed Wound Healing in Leukocyte Adhesion Deficiency Type 1. JOURNAL OF PEDIATRICS 158 2 342 2011/02
- Human heme oxygenase-1 deficiency presenting with hemolysis, nephritis, and asplenia. Radhakrishnan N, Yadav SP, Sachdeva A, Pruthi PK, Sawhney S, Piplani T, Wada T, Yachie A. JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY 33 1 74-78 2011/01
- Colchicine responsive chronic recurrent multifocal osteomyelitis with MEFV mutations: A variant of familial Mediterranean fever? Shimizu M, Tone Y, Toga A, Yokoyama T, Wada T, Toma T, Yachie A. RHEUMATOLOGY 49 11 2221-2223 2010/11
- Differential resistance to antiviral drugs in an immunocompromised patient with cytomegalovirus encephalitis. Wada T, Mase S, Shibata F, Shimizu M, Toma T, Yachie A. JOURNAL OF CLINICAL VIROLOGY 49 3 223-224 2010/11
- Distinct cytokine profiles of systemic juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis. Shimizu M, Yokoyama T, Yamada K, Kaneda H, Wada H, Wada T, Toma T, Ohta K, Kasahara Y, Yachie A. RHEUMATOLOGY 49 9 1645-1653 2010/09
- Bicipital synovial cyst in systemic-onset juvenile idiopathic arthritis. JOURNAL OF PEDIATRICS 157 1 168 2010/07
- Clinical significance of CD5 downregulation in Epstein-Barr virus (EBV)-infected CD8+ T lymphocytes in EBV-associated hemophagocytic lymphohistiocytosis. Toga A, Wada T, Sakakibara Y, Mase S, Araki R, Tone Y, Toma T, Kurokawa T, Yanagisawa R, Tamura K, Nishida N, Taneichi H, Kanegane H, Yachie A. JOURNAL OF INFECTIOUS DISEASES 201 12 1923-1932 2010/06
- Flow cytometric analysis of skin blister fluid induced by mosquito bites in a patient with chronic active Epstein-Barr virus infection Wada T, Yokoyama T, Nakagawa H, Asai E, Toga A, Sakakibara Y, Shibata F, Tone Y, Shimizu M, Toma T, Yachie A. INTERNATIONAL JOURNAL OF HEMATOLOGY 90 5 611-615 2009/12
- Hypokalemic periodic paralysis and mutations in the CACNL1A3 gene: case study in a Japanese family. Wada T, Yachie A, Fujita S, Takei K, Sumita R, Ichihara T, Koizumi S PEDIATRICS INTERNATIONAL 42 3 325-327 2000/06
- Complete arrest from pro- to pre-B cells in a case of B cell-negative severe combined immunodeficiency (SCID) without recombinase activating gene (RAG) mutations. Agematsu K, Nagumo H, Hokibara S, Mori T, Wada T, Yachie A, Kanegane H, Miyawaki T, Sugita K, Karasuyama H, Komiyama A CLINICAL AND EXPERIMENTAL IMMUNOLOGY 124 3 461-464 2001/06
- Somatic mosaicism in Wiskott-Aldrich syndrome suggests in vivo reversion by a DNA slippage mechanism. Wada T, Schurman SH, Otsu M, Garabedian EK, Ochs HD, Nelson DL, Candotti F PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME 98 15 8697-8702 2001/07
- Analysis of T cell receptor Vβ diversity in peripheral CD4+ and CD8+ T lymphocytes in patients with autoimmune thyroid diseases. Okajima M, Wada T, Nishida M, Yokoyama T, Nakayama Y, Hashida Y, Shibata F, Tone Y, Ishizaki A, Shimizu M, Saito T, Ohta K, Toma T, Yachie A CLINICAL AND EXPERIMENTAL IMMUNOLOGY 155 2 166-172 2009/02
- Detection of T lymphocytes with a second-site mutation in skin lesions of atypical X-linked severe combined immunodeficiency mimicking Omenn syndrome. Wada T, Yasui M, Toma T, Nakayama Y, Nishida M, Shimizu M, Okajima M, Kasahara Y, Koizumi S, Inoue M, Kawa K, Yachie A BLOOD 112 5 1872-1875 2008/09
- Immunophenotypic analysis of Epstein-Barr virus (EBV)-infected CD8+ T cells in a patient with EBV-associated hemophagocytic lymphohistiocytosis. Wada T, Kurokawa T, Toma T, Shibata F, Tone Y, Hashida Y, Kaya H, Yoshida T, Yachie A EUROPEAN JOURNAL OF HAEMATOLOGY 79 1 72-75 2007/07
- Skin infiltration of CD56bright CD16- natural killer cells in a case of X-SCID with Omenn syndrome-like manifestations. Shibata F, Toma T, Wada T, Inoue M, Tone Y, Ohta K, Kasahara Y, Sano F, Kimura M, Ikeno M, Koizumi S, Yachie A EUROPEAN JOURNAL OF HAEMATOLOGY 79 1 81-85 2007/07
- Clonotypic analysis of T cell reconstitution after haematopoietic stem cell transplantation (HSCT) in patients with severe combined immunodeficiency. Okamoto H, Arii C, Shibata F, Toma T, Wada T, Inoue M, Tone Y, Kasahara Y, Koizumi S, Kamachi Y, Ishida Y, Inagaki J, Kato M, Morio T, Yachie A CLINICAL AND EXPERIMENTAL IMMUNOLOGY 148 3 450-460 2007/06
- Reactive peripheral blood plasmacytosis in a patient with acute hepatitis A. Wada T, Maeba H, Ikawa Y, Hashida Y, Okumura A, Shibata F, Tone Y, Inoue M, Koizumi S, Takatori H, Sakai Y, Kaneko S, Yachie A INTERNATIONAL JOURNAL OF HEMATOLOGY 85 3 191-194 2007/04
- Somatic revertant mosaicism in a patient with leukocyte adhesion deficiency type 1. Tone Y, Wada T, Shibata F, Toma T, Hashida Y, Kasahara Y, Koizumi S, Yachie A BLOOD 109 3 1182-1184 2007/02
- Analysis of T-cell repertoire diversity in Wiskott-Aldrich syndrome. Wada T, Schurman SH, Garabedian EK, Yachie A, Candotti F BLOOD 106 12 3895-3897 2005/12
- Oligoclonal expansion of T lymphocytes with multiple second-site mutations leads to Omenn syndrome in a patient with RAG1-deficient severe combined immunodeficiency. Wada T, Toma T, Okamoto H, Kasahara Y, Koizumi S, Agematsu K, Kimura H, Shimada A, Hayashi Y, Kato M, Yachie A BLOOD 106 6 2099-2101 2005/09
- Multiple patients with revertant mosaicism in a single Wiskott-Aldrich syndrome family. Wada T, Schurman SH, Jagadeesh GJ, Garabedian EK, Nelson DL, Candotti F BLOOD 104 5 1270-1272 2004/10
- Paradoxical enhancement of oxidative cell injury by overexpression of heme oxygenase-1 in an anchorage-dependent cell ECV304. Maruhashi K, Kasahara Y, Ohta K, Wada T, Ohta K, Nakamura N, Toma T, Koizumi S, Yachie A JOURNAL OF CELLULAR BIOCHEMISTRY 93 3 552-562 2004/10
- Differential contribution of Wiskott-Aldrich syndrome protein to selective advantage in T- and B-cell lineages. Konno A, Wada T, Schurman SH, Garabedian EK, Kirby M, Anderson SM, Candotti F BLOOD 103 2 676-678 2004/01
- Second-site mutation in the Wiskott-Aldrich syndrome (WAS) protein gene causes somatic mosaicism in two WAS siblings. Wada T, Konno A, Schurman SH, Garabedian EK, Anderson SM, Kirby M, Nelson DL, Candotti F JOURNAL OF CLINICAL INVESTIGATION 111 9 1389-1397 2003/05
- Retrovirus-mediated WASP gene transfer corrects Wiskott-Aldrich syndrome T-cell dysfunction. Wada T, Jagadeesh GJ, Nelson DL, Candotti F HUMAN GENE THERAPY 13 9 1039-1046 2002/06
- Age-dependent increase of IgE-binding and FcεRI expression on circulating basophils in children. Wada T, Toma T, Shimura S, Kudo M, Kasahara Y, Koizumi S, Ra C, Seki H, Yachie A PEDIATRIC RESEARCH 46 5 603-607 1999/11
- Diffuse brain damage caused by acute twin-twin transfusion during late pregnancy. Wada H, Nunogami K, Wada T, Niida Y, Yachie A, Koizumi S ACTA PAEDIATRICA JAPONICA 40 4 370-373 1998/08
- A syndrome of peripheral blood T-cell infection with Epstein-Barr virus (EBV) followed by EBV-positive T-cell lymphoma. Kanegane H, Bhatia K, Gutierrez M, Kaneda H, Wada T, Yachie A, Seki H, Arai T, Kagimoto S, Okazaki M, Oh-ishi T, Moghaddam A, Wang F, Tosato G BLOOD 91 6 2085-2091 1998/02
- Developmental changes and functional properties of human memory T cell subpopulations defined by CD60 expression. Wada T, Seki H, Konno A, Ohta K, Nunogami K, Kaneda H, Kasahara Y, Yachie A, Koizumi S, Taniguchi N, Miyawaki T CELLULAR IMMUNOLOGY 187 2 117-123 1998/08
- Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. Yachie A, Niida Y, Wada T, Igarashi N, Kaneda H, Toma T, Ohta K, Kasahara Y, Koizumi S JOURNAL OF CLINICAL INVESTIGATION 103 1 129-135 1999/01
- Characterization of immune function and analysis of RAG gene mutations in Omenn syndrome and related disorders. Wada T, Takei K, Kudo M, Shimura S, Kasahara Y, Koizumi S, Kawa-Ha K, Ishida Y, Imashuku S, Seki H, Yachie A CLINICAL AND EXPERIMENTAL IMMUNOLOGY 119 1 148-155 2000/01
- Inhibitory action of sulfatide, a putative ligand for L-selectin, on B cell proliferation and Ig production. Konno A, Nunogami K, Wada T, Yachie A, Suzuki Y, Takahashi N, Suzuki T, Miyamoto D, Kiso M, Hasegawa A, Miyawaki T INTERNATIONAL IMMUNOLOGY 8 12 1905-1913 1996/02
- Novel Fas (CD95/APO-1) mutations in infants with a lymphoproliferative disorder. Kasahara Y, Wada T, Niida Y, Yachie A, Seki H, Ishida Y, Sakai T, Koizumi F, Koizumi S, Miyawaki T, Taniguchi N INTERNATIONAL IMMUNOLOGY 10 2 195-202 1998/02
- Delineation of producing ability of IgG and IgA subclasses by naive B cells in newborn infants and adult individuals. Yachie A, Konno A, Ohta K, Wada T, Seki H, Taniguchi N, Miyawaki T CLINICAL AND EXPERIMENTAL IMMUNOLOGY 102 1 204-209 1995/10
- Tubular injury as a cardinal pathologic feature in human heme oxygenase-1 deficiency. Ohta K, Yachie A, Fujimoto K, Kaneda H, Wada T, Toma T, Seno A, Kasahara Y, Yokoyama H, Seki H, Koizumi S AMERICAN JOURNAL OF KIDNEY DISEASES 35 5 863-870 2000/05
Conference Presentations
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「自己炎症性疾患とその類縁疾患の全国診療体制整備、移行医療体制の構築、診療ガイドライン確立に関する研究」(2022-2025)
○「慢性肉芽腫症腸炎に対する小児用サリドマイド製剤の実用化に関する研究」(2019-2021)
○「原発性免疫不全症候群の診療ガイドライン改訂、診療提供体制・移行医療体制構築、データベースの確立に関する研究」(2020-2022)
○「自己炎症性疾患とその類縁疾患の全国診療体制整備、移行医療体制の構築、診療ガイドライン確立に関する研究」(2020-2022)
○「新規胚シグナルlaeverinの幹細胞と免疫システムに対する作用の解明と臨床応用」(2021-2024)
○2022「血中IL-18の異常高値で特徴付けられる疾患群の病態解明と治療法開発」(2020-2022)
○「原発性免疫不全症候群の診断基準・重症度分類および診療ガイドラインの確立に関する研究」(2019-2019)
○「慢性活動性EBウイルス感染症と類縁疾患の疾患レジストリとバイオバンクの構築」(2019-2019)
○「オミクス情報を駆使した全身型特発性関節炎分子病態の解明と先制医療開発」(2015-2018)
○「好中球二次顆粒欠損症の新規Ｃ／ＥＢＰε変異と好中球分化異常に関する研究」(2015-2017)
○「原発性免疫不全症における原因遺伝子の復帰に関する研究」(2006-2007)
○「原発性免疫不全症における復帰変異による体細胞モザイクの意義と分子生物学的基盤」(2008-2010)
○「EBV関連血球貪食性リンパ組織球症におけるEBV感染T細胞の解析と病態解明」(2012-2014)