last modified：2025/04/08
Professor HARADA Kenichi
Faculty, Affiliation
Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences Department of Human Pathology
College and School Educational Field
Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
Laboratory
Human Pathology TEL:076-265-2195 FAX:076-234-4229
Academic Background
【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor Graduate School, Division of Medicine 199603 Completed
【Academic background(Bachelor's Degree)】
Kanazawa University 199103
Career
Kanazawa University(2007/02-2014/04)
(2014/05-)
(1997-2007)
Year & Month of Birth
Academic Society
The Clinical Electron Microscopy Society of Japan
Award
Specialities
Human pathology、Experimental pathology、Immunology
Speciality Keywords
Immunology,Pathology,Liver
Research Themes
Pathology of the liver
I conduct basic analysis for pathological analysis and treatment strategies of hepatobiliary system diseases based on hepatic and biliary cell physiology and hepatic immunity analysis.
Immunology of the liver
Liver cancer
Books
- 原発性肝癌取扱い規約 第6版 補訂版 2019/03
- Kenichi Harada Biliary Diseases with Pancreatic Counterparts NOVA 2017
- Kenichi Harada Pathology of the Bile Duct Springer 2017
- Kenichi Harada, Yoshifumi Ubara IgG4-Related Kidney Diseases Springer 2016
- Kenichi Harada The Liver in Systemic Diseases （Hiromasa Ohira Editor） Chapter 15 IgG4-Related Diseases and the liver Springer 2016
- Harada K, Nakanuma Y IgG4-Related Disease Sclerosing Cholangitis Springer Japan 2014
- Mechanisms of the Sclerosing Cholangiopathy in Biliary Atresia: Association with Biliary Innate Immunity and Epithelial-Mesenchymal Transition Kodansha Shuppan Service Center 2009/11
Papers
- Biliary Innate Immunity in the Pathogenesis of Biliary Diseases １ ９ 83-90
- Biliary Innate Immunity:Function and Modulation Nakanuma Y Volume 2010, Article
- Cell-kinetic study of proliferating bile ductules in various hepatobiliary diseases LIVER 18 4 277-284 1998/04
- Distribution of apoptotic cells and expression of apoptosis-related proteins along the intrahepatic biliary tree in normal and non-biliary diseased liver HISTOPATHOLOGY 37 4 347-354 2000/04
- Enhanced apoptosis relates to bile duct loss in primary biliary cirrhosis HEPATOLOGY 26 6 1399-1405 1997/12
- Enhanced expression of basement-membrane-type heparan sulfate proteoglycan in tumor fibromyxoid stroma of intrahepatic cholangiocarcinoma Pathol Int 51 4 248-256 2001/04
- Epithelioid cell granulomas in chronic hepatitis C: Immunohistochemical character and histological marker of favourable response to interferon alpha therapy HISTOPATHOLOGY 33 3 216-221 1998/03
- Frequent molecular identification of Campylobacter but not Helicobacter genus in bile and biliary epithelium in hepatholithiasis J Pathol 193 2 218-223 2001/02
- Human Reg l is up-regulated in intrahepatic cholangiocarcinoma and its precursor lesions HEPATOLOGY 33 5 1036-1042 2001/05
- In situ nucleic acid detection of PDC-E2, BCOADC-E2 OGDC-E-2, PDC-E l alpha, BCOADC-E l alpha, and the E3 binding protein (Protein X) in primary biliary cirrhosis HEPATOLOGY 30 1 36-45 1999/01
- In situ nucleic acid hybridization of cytokines in primary biliary cirrhosis: predominance of the Th1 subset HEPATOLOGY 25 4 791-796 1997/04
- In situ nucleic acid hybridization of pyruvate dehydrogenase complex-E2 in primary biliary cirrhosis: pyruvate dehydrogenase complex-E2 messenger RNA is expressed in hepatocytes but not in biliary epithelium HEPATOLOGY 25 1 27-32 1997/01
- Increased expression of WAF1 in intrahepatic bile ducts in primary biliary cirrhosis relates to apoptosis J Hepatol 34 4 500-506 2001/04
- Molecular identification of bacterial 16S ribosomal RNA gene in liver tissue of primary biliary cirrhosis: Is Propionibacterium acnes involved in granuloma formation ? HEPATOLOGY 33 3 530-536 2001/03
- PCR and in situ hybridization studies of telomerase subunits in human non-neoplsatic livers J Pathol 193 2 210-217 2001/02
- Significance of CD30-positive lymphocytes in primary biliary cirrhosis J Gastroenterol Hepatol 14 12 1197-1202 1997/12
- Accumulating CD57 + CD3 + natural killer T cells are related to intrahepatic bile duct lesions in primary biliary cirrhosis. LIVER 23 2 94-100 2003/04
- Osteopontin is involved in the formation of epithelioid granuloma and bile duct injury in primary biliary cirrhosis. PATHOLOGY INTERNATIONAL 35 1 8-17 2003/01
- Lipopolysaccharide activates nuclear factor-kappaB through toll-like receptors and related molecules in cultured biliary epithelial cells. LABORATORY INVESTIGATION 83 11 1657-1667 2003/11
- Reduced expression of syndecan-1 correlates with histologic dedifferentiation, lymph node metastasis, and poor prognosis in intrahepatic cholangiocarcinoma. HUMAN PATHOLOGY 34 9 857-863 2003/09
- Type1 and type2 memory T cells imbalance shown by expression of intrahepatic chemokine receptors relates to pathogenesis of primary biliary cirrhosis. 24 3 290-299 2002/11
- Th1 cytokine-induced downregulation of PPARgamma in human biliary cells relates to cholangitis in primary biliary cirrhosis. HEPATOLOGY 41 6 1329-1338 2005/06
- Peptide Antibiotic Human Beta-Defensin-1 and -2 Constitute Antimicrobial Defense in the Intrahepatic Biliary Tree HEPATOLOGY 40 4 925-932 2004/10
- Innate immune response to double-stranded RNA in biliary epithelial cells is associated with the pathogenesis of biliary atresia. HEPATOLOGY 27;46(4) 1146-1154 2007/07
- Induction of innate immune response and absence of subsequent tolerance to dsRNA in biliary epithelial cells relate to the pathogenesis of biliary atresia. Liver Int 28(5) 614-21 2008/05
- Epithelial-mesenchymal transition induced by biliary innate immunity contributes to the sclerosing cholangiopathy of biliary atresia. J Pathol. 217(5) 654-64 2009
- Periductal interleukin-17 production in association with biliary innate immunity contributes to the pathogenesis of cholangiopathy in primary biliary cirrhosis. Clin Exp Immunol. 157(2):261-70 2009/08
- A case of hepatic small vessel neoplasm without previously reported hotspot mutation of alpha subfamily of G proteins. Minako Yamamura,Yasunori Sato,Kenta Takahashi,Hiep Nguyen Canh,Zihan Li,Kazuyoshi Hosomichi,Atsushi Tajima,Takuro Terada,Yasuni Nakanuma,Kenichi Harada Human Pathology Reports 29 300660 2022/09
- Non-occlusive mesenteric ischemia during bevacizumab treatment for glioblastoma: a case report. Nozomu Oikawa,Masashi Kinoshita,Minako Yamamura,Takehiro Uno,Toshiya Ichinose,Hemragul Sabit,Tomoyuki Hayashi,Dai Inoue,Kenichi Harada,Mitsutoshi Nakada Acta neurochirurgica 164 10 2767 2022/07/30
- Safety, tolerability, and anti-fibrotic efficacy of the CBP/β-catenin inhibitor PRI-724 in patients with hepatitis C and B virus-induced liver cirrhosis: An investigator-initiated, open-label, non-randomised, multicentre, phase 1/2a study Kiminori Kimura,Tatsuya Kanto,Shinji Shimoda,Kenichi Harada,Masamichi Kimura,Koji Nishikawa,Jun Imamura,Eiichi Ogawa,Masanao Saio,Yoshihiro Ikura,Takuji Okusaka,Kazuaki Inoue,Tetsuya Ishikawa,Ichiro Ieiri,Junji Kishimoto,Koji Todaka,Terumi Kamisawa eBioMedicine 80 104069 2022/06
- Anti-inflammatory and antifibrotic effects of CBP/β-catenin inhibitor for hepatocytes: small molecular inhibitor, OP-724 possibly improves liver function Hirofumi Ouchi,Yuki Mizutani,Kaori Yoshimura,Yasunori Sato,Kiminori Kimura,Yushi Haruyama,Kenichi Harada Medical Molecular Morphology 56 2 94 2023/01/16
- Clinical practice guidelines for autoimmune hepatitis. Hiromasa Ohira,Atsushi Takahashi,Mikio Zeniya,Masanori Abe,Teruko Arinaga-Hino,Satoru Joshita,Akinobu Takaki,Nobuhiro Nakamoto,Jong-Hon Kang,Yoshiyuki Suzuki,Tsuyosi Sogo,Ayano Inui,Kazuhiko Koike,Kenichi Harada,Yasunari Nakamoto,Yasuteru Kondo,Takuya Genda,Koichi Tsuneyama,Tsuyoshi Matsui,Atsushi Tanaka Hepatology research : the official journal of the Japan Society of Hepatology 52 7 571 2022/07
- Comparison of Tofogliflozin and Glimepiride Effects on Nonalcoholic Fatty Liver Disease in Participants With Type 2 Diabetes: A Randomized, 48-Week, Open-Label, Active-Controlled Trial. Yumie Takeshita,Masao Honda,Kenichi Harada,Yuki Kita,Noboru Takata,Hiromasa Tsujiguchi,Takeo Tanaka,Hisanori Goto,Yujiro Nakano,Noriho Iida,Kuniaki Arai,Tatsuya Yamashita,Eishiro Mizukoshi,Hiroyuki Nakamura,Shuichi Kaneko,Toshinari Takamura Diabetes care 45 9 2064 2022/09/01
- Dynamic CT and Gadoxetic Acid-enhanced MRI Characteristics of P53-mutated Hepatocellular Carcinoma. Azusa Kitao,Osamu Matsui,Yu Zhang,Takahiro Ogi,Satoko Nakada,Yasunori Sato,Kenichi Harada,Norihide Yoneda,Kazuto Kozaka,Dai Inoue,Kotaro Yoshida,Wataru Koda,Taro Yamashita,Tatsuya Yamashita,Shuichi Kaneko,Satoshi Kobayashi,Toshifumi Gabata Radiology 220531 2022/10/11
- Clinical trial of autologous adipose tissue-derived regenerative (stem) cells therapy for exploration of its safety and efficacy. Yoshio Sakai,Shinya Fukunishi,Masayuki Takamura,Kazunori Kawaguchi,Oto Inoue,Soichiro Usui,Shinichiro Takashima,Akihiro Seki,Akira Asai,Yusuke Tsuchimoto,Alessandro Nasti,Tuyen Thuy Bich Ho,Yasuhito Imai,Kenichi Yoshimura,Toshinori Murayama,Taro Yamashita,Kuniaki Arai,Tatsuya Yamashita,Eishiro Mizukoshi,Masao Honda,Takashi Wada,Kenichi Harada,Kazuhide Higuchi,Shuichi Kaneko Regenerative therapy 18 97 2021/12
- A novel pathologic marker, indoleamine 2,3-dioxygenase 1, for the cholangiopathy of immune checkpoint inhibitors-induced immune mediated hepatotoxicity as adverse events and the prediction of additional ursodeoxycholic acid treatment Kaori Yoshimura,Yuko Tamano,Hiep Nguyen Canh,Li Zihan,Dong Le Thanh,Yasunori Sato,Takeshi Terashima,Shinji Shimoda,Kenichi Harada Medical Molecular Morphology 56 2 106 2023/01/04
- A case of focal nodular hyperplasia-like lesion presenting unusual signal intensity on the hepatobiliary phase of gadoxetic acid-enhanced magnetic resonance image. Kumi Ozaki,Norihide Yoneda,Kenichi Harada,Hiroshi Ikeno,Misa Takahashi,Yasuharu Kaizaki,Kazuya Maeda,Shohei Higuchi,Kenji Takata,Toshifumi Gabata Radiology case reports 18 9 3093 2023/09
- Successful second conversion surgery after trastuzumab deruxtecan for recurrent HER2-positive gastric cancer. Takeshi Terashima,Tatsuya Yamashita,Hisashi Takabatake,Shinichi Nakanuma,Jun Kinoshita,Shintaro Yagi,Eishiro Mizukoshi,Kenichi Harada,Sachio Fushida,Shuichi Kaneko Clinical journal of gastroenterology 2023/01/28
- Inhibition of CBP/β-catenin signaling ameliorated fibrosis in cholestatic liver disease. Masamichi Kimura,Koji Nishikawa,Yosuke Osawa,Jun Imamura,Kenzaburo Yamaji,Kenichi Harada,Hiroshi Yatsuhashi,Kazumoto Murata,Kouichi Miura,Atsushi Tanaka,Tatsuya Kanto,Michinori Kohara,Terumi Kamisawa,Kiminori Kimura Hepatology communications 6 10 2732 2022/10
- Reactive lymphoid hyperplasia of the liver: A case report featuring characteristic nodular and perinodular enhancement. Hirohito Osanai,Kazuto Kozaka,Norihide Yoneda,Kotaro Yoshida,Azusa Kitao,Toshifumi Gabata,Kenichi Harada,Isamu Makino,Satoshi Kobayashi Radiology case reports 19 5 1998 2024/05
- The disturbance of the distribution of T helper cell subsets in the mantle area surrounding germinal centers in immunoglobulin G4-related sclerosing sialadenitis. Satomi Kasashima,Atsuhiro Kawashima,Nozomu Kurose,Satoru Ozaki,Hiroko Ikeda,Kenichi Harada Virchows Archiv : an international journal of pathology 2022/07/28
- The Challenges of Primary Biliary Cholangitis: What is new and what needs to be done Benedetta Terziroli Beretta-Piccoli,Kenichi Harada,et al. J Autoimmunity 105 102328 2019
- A Long-term Survival after Surgical Treatment for Atypical Aortic Coarctation Complicating Takayasu Arteritis with Inactive Disease at the Diagnosis: An Appropriately Treated Autopsy Case. Yoshida M, Zoshima T, Hara S, Mizushima I, Fujii H, Yamada K, Sato Y, Harada K, Kawano M. Intern Med. 58 15 2241-2246 2019
- A case of IgG4-related tubulointerstitial nephritis and membranous glomerulonephritis during the clinical course of gastric cancer: Imaging features of IgG4-related kidney disease. Horita S, Fujii H, Mizushima I, Fujisawa Y, Hara S, Yamada K, Inoue D, Nakajima K, Harada K, Kawano M. Mod Rheumatol. 29 3 542-546 2019
- Expression of fatty‑acid‑binding protein 5 in intrahepatic and extrahepatic cholangiocarcinoma: the possibility of different energy metabolisms in anatomical location Risa Nakagawa, Nguyen Canh Hiep, Hirofumi Ouchi, Yasunori Sato, Kenichi Harada. Medical Molecular Morphology 2019
- Expression of endoplasmic reticulum oxidoreductase 1-α in cholangiocarcinoma tissues and its effects on the proliferation and migration of cholangiocarcinoma cells Wendi Yan, Xue Wang,1, Tesi Liu, Liyan Chen, Longzhe Han, Jing Xu, Guihua Jin, Kenichi Harada, Zhenhua Lin, Xiangshan Ren Cancer Management and Research 11 6727–6739 2019
- A case of primary biliary cholangitis overlapping with type 2 autoimmune hepatitis Nozomi Amano, Sho Sato, Ayato Murata, Hironori Tsuzura, Ko Tomishima, Shunsuke Sato, Kohei Matsumoto, Yuji Shimada, Katsuyori Iijima, Kenichi Harada, Takuya Genda. Clinical Journal of Gastroenterology 2019
- Case of metastatic glioblastoma with primitive neuronal component to the lung Sho Tamai, Masashi Kinoshita, Hemragul Sabit, Takuya Furuta, Katsuyoshi Miyashita,Kaori Yoshimura, Taku Homma, Kenichi Harada and Mitsutoshi Nakada Neuropathology 39 218–223 2019
- Serum C16:1n7/C16:0 ratio as a diagnostic marker for nonalcoholic steatohepatitis Kazutoshi Yamada,Kenichi Harada,et al. Journal of Gastroenterology and Hepatology 2019
- A case of chronic pancreatitis exacerbation associated with pancreatic arteriovenous malformation: a case report and literature review. Seike T, Harada K, et al. Clinical journal of gastroenterology 12 2 135-141 2019
- 糖尿病の若年女性に生じた炎症性肝細胞腺腫の1例 64 183-189 2019/02
- Unclassified hepatocellular adenoma in a middle-aged woman with glucose intolerance. Ozaki K, Harada K, Yamamoto T, Aoyagi H, Kaizaki Y, Yoshikawa J. Clin J Gastroenterol. 2017
- Usefulness of laparoscopy and intraductal ultrasonography in a patient with isolated immunoglobulin G4-related sclerosing cholangitis. Ohno Y, Kumagi T, Imamura Y, Kuroda T, Koizumi M, Watanabe T, Yoshida O, Tokumoto Y, Takeshita E, Abe M, Harada K, Hiasa Y. Clin J Gastroenterol. 2017
- Role for Neutrophil Extracellular Traps (NETs) and Platelet Aggregation in Early Sepsis-induced Hepatic Dysfunction. Sakurai K, Miyashita T, Okazaki M, Yamaguchi T, Ohbatake Y, Nakanuma S, Okamoto K,Sakai S, Kinoshita J, Makino I, Nakamura K, Hayashi H, Oyama K, Tajima H, Takamura H, Ninomiya I, Fushida S, Harada K, Harmon JW, Ohta T. In Vivo. 31 6 1051-1058. 2017
- BRAF V600E, TERT promoter mutations and CDKN2A/B homozygous deletions are frequent in epithelioid glioblastomas: A histological and molecular analysis focusing on intratumoral heterogeneity. Nakajima N, Nobusawa S, Nakata S, Nakada M, Yamazaki T, Matsumura N, Harada K, Matsuda H, Funata N, Nagai S, Nakamura H, Sasaki A, Akimoto J, Hirato J, Yokoo H. Brain Pathol. 2017
- Clinicopathological Study of Autoimmune Hepatitis Cases That Were Difficult to Differentiate from Drug-Induced Liver Injury. Tsutsui A, Harada K, Tsuneyama K, Senoh T, Nagano T, Takaguchi K, Ando M, Nakamura S, Mizobuchi K, Kudo M. Dig Dis. 35 6 506-514. 2017
- Sclerosing and obstructive cholangiopathy in biliary atresia: mechanisms and association with biliary innate immunity Kenichi Harada Pediatr Surg Int 2017
- Clinical features of cystatin A expression in patients with pancreatic ductal adenocarcinoma. Komura T, Takabatake H, Harada K, Yamato M, Miyazawa M, Yoshida K, Honda M, Wada T, Kitagawa H, Ohta T, Kaneko S, Sakai Y. Cancer Sci. 2017
- A case of ruptured hepatocellular carcinoma (HCC) in resolving non-alcoholic steatohepatitis associated with type 2 diabetes: Is early detection of diabetes-related HCC feasible? Ikura Y, Tiniakos DG, Tanaka T, Harada K. J Diabetes. 9 3 311-313. 2017
- Gadoxetic acid-enhanced magnetic resonance imaging reflects co-activation of β-catenin and hepatocyte nuclear factor 4α in hepatocellular carcinoma. Kitao A, Matsui O, Yoneda N, Kozaka K, Kobayashi S, Koda W, Minami T, Inoue D, Yoshida K, Yamashita T, Yamashita T, Kaneko S, Takamura H, Ohta T, Ikeda H, Sato Y, Nakanuma Y, Harada K, Kita R, Gabata T. Hepatol Res. 2017
- Diagnostic sensitivity of cutoff values of IgG4-positive plasma cell number and IgG4-positive/CD138-positive cell ratio in typical multiple lesions of patients with IgG4-related disease. Mizushima I, Yamada K, Harada K, Matsui S, Saeki T, Kondo S, Takahira M, Waseda Y, Hamaguchi Y, Fujii H, Yamagishi M, Kawano M. Mod Rheumatol. 22 1-7 2017
- Challenges and difficulties in pathological diagnosis of autoimmune hepatitis. Harada K, Hiep NC, Ohira H. Hepatol Res. 47 10 963-971 2017
- Safety, Tolerability, and Preliminary Efficacy of the Anti-Fibrotic Small Molecule PRI-724, a CBP/β-Catenin Inhibitor, in Patients with Hepatitis C Virus-related Cirrhosis: A Single-Center, Open-Label, Dose Escalation Phase 1 Trial Kimura K, Ikoma A, Shibakawa M, Shimoda S, Harada K, Saio M, Imamura J, Osawa Y, Kimura M, Nishikawa K, Okusaka T, Morita S, Inoue K, Kanto T, Todaka K, Nakanishi Y, Kohara M, Mizokami M. E Bio Medicine 2017
- The simultaneous inhibition of the mTOR and MAPK pathways with Gnetin-C induces apoptosis in acute myeloid leukemia Espinoza JL, Elbadry MI , Taniwaki M , Harada K ,Trung LQ , Nakagawa N , Takami A , Ishiyama K ,Yamauchi T, Takenaka K , Nakao S. Cancer Letters 400 127-136 2017
- Acute presentation of autoimmune hepatitis: a multicentre study with detailed histological evaluation in a large cohort of patients. Hiep NC, Harada K, Ouchi H, Sato Y,Tsuneyama , Kage M, Nakano M, Yoshizawa K, Takahashi A, Abe , Kang JH, Koike K, Inui A, Fujisawa T, Takaki A, Arinaga-Hino T, Torimura T, Suzuki Y, Fujiwara K, Zeniya Ohira H, Tanaka A, Takikawa H; Intractable Liver and Biliary Diseases Study Group of Japan. J Clin Pathol. 2017
- Rathke Cleft Cyst with Entirely Ossified Cyst Wall and Partially Solid Cyst Content: A Case Report and Literature Review Hayashi Y, Oishi M, Fukui I, Sasagawa Y, Harada K, Nakada M. World Neurosurg. 2017 Feb;98:882.e15-882.e20. 2017
- The PD-1/PD-L1 axis may be aberrantly activated in occupational cholangiocarcinoma Sato Y, Masahiko Kinoshita M, Takemura S, Tanaka S, Hamano G, Nakamori S, Fujikawa M, Sugawara Y, Yamamoto T, Arimoto A, Yamamura M, Sasaki M, Harada K, Nakanuma Y and Kubo S. Pathol Int. 67 3 163-170 2017
- Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal paucity of alterations in TP53 and SMAD4. Hosoda W, Chianchiano P, Griffin JF, Pittman ME, Brosens LA, Noë M, Yu J, Shindo K, Suenaga M, Rezaee N, Yonescu R, Ning Y, Albores-Saavedra J, Yoshizawa N, Harada K, Yoshizawa A, Hanada K, Yonehara S, Shimizu M, Uehara T, Samra JS, Gill AJ, Wolfgang CL, Goggins MG, Hruban RH, Wood LD. J Pathol. 242 1 16-23 2017
- Expression and localization of sterile alpha motif domain containing 5 is associated with cell type and malignancy of biliary tree. Yagai T, Matsui S, Harada K, Inagaki F, Saijou E, Miura Y, Nakanuma Y, Miyajima A, Tanaka M. PLoS One. 12 4 e0175355. 2017
- Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for primary biliary cholangitis in the Japanese population. Kawashima M, Hitomi Y, Aiba Y, Nishida N, Kojima K, Kawai Y, Nakamura H, Tanaka A,Zeniya M, Hashimoto E, Ohira H, Yamamoto K, Abe M, Nakao K, Yamagiwa S, Kaneko S, Honda M, Umemura T, Ichida T, Seike M, Sakisaka S, Harada M, Yokosuka O, Ueno Y, Senju M, Kanda T, Shibata H, Himoto T, Murata K, Miyake Y, Ebinuma H, Taniai M, Joshita S, Nikami T, Ota H, Kouno H, Kouno H, Nakamuta M, Fukushima N, Kohjima M,Komatsu T, Komeda T, Ohara Y, Muro T, Yamashita T, Yoshizawa K, Nakamura Y, Shimada M, Hirashima N, Sugi K, Ario K, Takesaki E, Naganuma A, Mano H, Yamashita H, Matsushita K, Yamauchi K, Makita F, Nishimura H, Furuta K, Takahashi N, Kikuchi M, Masaki N, Tanaka T, Tamura S, Mori A, Yagi S, Shirabe K, Komori A, Migita K, Ito M, Nagaoka S, Abiru S, Yatsuhashi H, Yasunami M, Shimoda S, Harada K, Egawa H, Maehara Y, Uemoto S, Kokudo N, Takikawa H, Ishibashi H, Chayama K, Mizokami M, Nagasaki M, Tokunaga K, Nakamura M. Hum Mol Genet. 26 3 650-659 2017
- Pathological findings of nonalcoholic steatohepatitis and nonalcoholic fatty liver disease. Sakamoto M, Tsujikawa H, Effendi K, Ojima H, Harada K, Zen Y, Kondo F, Nakano M, Kage M, Sumida Y, Hashimoto E, Yamada G, Okanoue T, Koike K. Pathol Int. 67 1 1-7 2017
- 正常肝に発生した細胆管細胞癌の１例 49 10 1006-1015 2016
- Adult bile duct strictures: differentiating benign biliary stenosis from cholangiocarcinoma Nguyen Canh Hiep, Kenichi Harada. Medical Molecular Morphology 2016
- Hepatocyte nuclear factor 1α-inactivated hepatocellular adenomas exhibit high 18F-fludeoxyglucose uptake associated with glucose-6-phosphate transporter inactivation Kumi Ozaki, Kenichi Harada, Noboru Terayama, Osamu Matsui, Satoshi Saitoh, Yoshito Tomimaru, Takeshi fujii, Toshifumi Gabata. Br J Radiol 2016
- Characterization of intraductal papillary neoplasm of bile duct with respect to histopathologic similarities to pancreatic intraductal papillary mucinous neoplasm. Nakanuma Y, Kakuda Y, Uesaka K, Miyata T, Yamamoto Y, Fukumura Y, Sato Y, Sasaki M, Harada K, Takase M. Hum Pathol. 51 103-13 2016
- Application and Validation of a New Histologic Staging and Grading System for Primary Biliary Cirrhosis. Harada K, Hsu M, Ikeda H, Zeniya M, Nakanuma Y. J Clin Gastroenterol 47 2 174-81 2013
- Participation of natural killer cells in the pathogenesis of bile duct lesions in biliary atresia Okamura, Atsushi; Harada, Kenichi; Nio, Masaki; Nakanuma, Yasuni Journal of Clinical Pathology 66 2 99-108 2013
- Tissue culture correlational study of genetic cholangiopathy of autosomal recessive polycystic kidney disease Nakanuma, Yasuni; Sato, Yasunori; Harada, Kenichi Methods in Molecular Biology 945 303-318 2013
- Clinicopathological significance of S100 protein expression in cholangiocarcinoma Sato, Yasunori; Harada, Kenichi; Sasaki, Motoko; Nakanuma, Yasuni Journal of Gastroenterology and Hepatology (Australia) 28 8 1422-1429 2013
- Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis. Harada K, Kakuda Y, Sato Y, Ikeda H, Shimoda S, Yamamoto Y, Inoue H, Ohta H, J Clin Pathol 2013
- Clinicopathological significance of serum fractalkine in primary biliary cirrhosis. Harada K, Kakuda Y, Nakamura M, Shimoda S, Nakanuma Y. Dig Dis Sci 58 10 3037-43 2013
- Histological characteristics of biliary intraepithelial neoplasia-3 and intraepithelial spread of cholangiocarcinoma. Sato Y, Harada K, Sasaki M, Nakanuma Y. Virchows Arch 462 4 421-7 2013
- Biliary adenofibroma with ominous features of imminent malignant changes Akemi Tsutsui, Yoshimi Bando, Yasunori Sato, Hidenori Miyake, Seiko Sawada-Kitamura, Clin J Gastroenterol. 2014
- What Are the Precursor and Early Lesions of Peripheral Intrahepatic Cholangiocarcinoma? Yasuni Nakanuma, Akemi Tsutsui, Xiang Shan Ren, Kenichi Harada, International Journal of Hepatology. 2014
- Extrahepatic Malignancies in Primary Biliary Cirrhosis: A Comparative Study at Two Europian Centers. Floreani A, Spinazze A, Caballeria L, Reig A, Cazzagon N, Franceschet I, Buja A, Furlan P, Clin Rev Allergy Immunol. 2014
- Histological characterization of biliary intraepithelial neoplasia with respect to pancreatic intraepithelial neoplasia. Yasunori Sato, Kenichi Harada, Motoko Sasaki, Yasuni Nakanuma. International Journal of Hepatology. 2014
- Systemic and local expression levels of TNF-like ligand 1A and its decoy receptor 3 are increased in primary biliary cirrhosis Yoshihiro Aiba, Kenichi Harada, Atsumasa Komori, Masahiro Ito, Shinji Shimoda, Liver International 34 679-688 2014
- Different carcinogenic process in cholangiocarcinoma cases epidemically developing among workers of a printing company in Japan Yasunori Sato, Shoji Kubo, Shigekazu Takemura, Yasuhiko Sugawara, Shogo Tanaka, Int J Clin Exp Pathol. 7 8 4745-4754 2014
- Clinical course after corticosteroid therapy in IgG4-related aortitis/periaortitis and periarteritis: a retrospective multicenter study Ichiro Mizushima, Dai Inoue, Motohisa Yamamoto, Kazunori Yamada, Takako Saeki, Arthritis Research & Therapy 16 4 R156 2014
- Cholangiocarcinoma with respect to IgG4 Reaction : Review Article Kenichi Harada, Yasuni Nakanuma. International Journal of Hepatology 2014
- Significance of oestrogen-related receptor γon biliary epithelial cells in the pathogenesis of primary biliary cirrhosis. Kenichi Harada, Kakuda Yuko, Yasunori Sato, Hiroko ikeda, Yasuni Nakanuma. J Clin Pathol. 67 566-572 2014
- Clinicopathological study of primary biliary cirrhosis with interface hepatitis compared to autoimmune hepatitis. Mio Kobayashi, Yuko Kakuda, Kenichi Harada, Yasunori Sato, Motoko Sasaki, World J Gastroenterol. 20 13 3597-3608 2014
- A condition closely mimicking IgG4-related disease despite the absence of serum IgG4 elevation and IgG4-positive plasma cell infiltration. Satoshi Hara, Mitsuhiro Kawano, Ichiro mizushima, Kazunori Yamada, Kentaro Fujita, MODERN RHEUMATOLOGY. 2 1-6 2014
- Prevalence and risk factors of hepatocellular carcinoma in Japanese patients with primary biliary cirrhosis. Harada K, Nakanuma Y. Hepatol Res 44 2 133-40 2014
- Activation of the PI3K/mTOR Pathway Is Involved in Cystic Proliferation of Cholangiocytes of the PCK Rat. Ren XS, Sato Y, Harada K, Sasaki M, Furubo S, Song JY, Nakanuma Y. PLoS One 30 9(1) e87660. 2014
- Cystic and micropapillary epithelial changes of peribiliary glands might represent a precursor lesion of biliary epithelial neoplasms. Sato Y, Harada K, Sasaki M, Nakanuma Y. Virchows Arch. 464 2 157-63 2014
- Guidelines for the management of primary biliary cirrhosis: The Intractable Hepatobiliary Disease Study Group supported by the Ministry of Health, Labour and Welfare of Japan. Working Subgroup (English version) for Clinical Practice Guidelines for Primary Biliary Hepatol Res. S1 71-90 2014
- Proposal of a new disease concept "biliary diseases with pancreatic counterparts". Anatomical and pathological bases. Nakanuma Y, Harada K, Sasaki M, Sato Y. Histol Histopathol 29 1 1-10 2014
- Multicentric Castleman Disease With Tubulointerstitial Nephritis Mimicking IgG4-related Disease: Two Case Reports. Zoshima T, Yamada K, Hara S, Mizushima I, Yamagishi M, Harada K, Sato Y, Kawano M. Am J Surg Pathol. 40 4 495-501 2016/04
- IgG4-related stomach muscle lesion with a renal pseudotumor and multiple renal rim-like lesions: A rare manifestation of IgG4-related disease. Inoue K, Okubo T, Kato T, Shimamura K, Sugita T, Kubota M, Kanaya K,Yamachika D, Mod Rheumatol. 18 1-5 2015/09
- Natural killer cells regulate T cell immune responses in primary biliary cirrhosis. Shimoda S, Hisamoto S, Harada K, Iwasaka S, Chong Y, Nakamura M, Bekki Hepatology. 2015/08
- Altered intrahepatic microcirculation of idiopathic portal hypertension in relation to glutamine synthetase expression Sato Y, Harada K, Sasaki M, Nakanuma Y. Hepatol Res 2015
- Autoantibody status and histological variables influence biochemical rewsponse to treatment and long-term outcomes in Japanese patients with primary biliary cirrhosis Nakamura M, Kondo H, Tanaka A, Komori A , Ito M, Yamamoto k, Ohira H,Zeniya M, Hepatol Res. 45 846-855 2015
- Inflammatory Features of Pancreatic Cancer Highlighted byMonocytes/Macrophages and CD4+ T cells with Clinical Impact. Komura T, Sakai Y, Harada K, Kawaguchi K, Takabatake H, Kitagawa H, Wada T, Cancer Sci. 106 6 672-86 2015/06
- A variant of multicystic biliary hamartoma presenting as an intrahepatic cystic neoplasm. Tominaga T, Abo T, Kinoshita N, Murakami T, Sato Y, Nakanuma Y, Harada K, Clin J Gastroenterol. 2015/05
- Autophagy and senescence in fibrosing cholangiopathies Nakanuma Y, Sasaki M, Harada K. Journal of Hepatology 62 934-945 2015
- Growth arrest and DNA damage-inducible 34 regulates liver regeneration in hepatic steatosis in mice. Inaba Y, Furutani T, Kimura K, Watanabe H, Haga S, Kido Y, Matsumoto M, Yamamoto Y, Hepatology. 2015 61(4) 1343-56 2015/04
Conference Presentations
- Mechanisms of the sclerosing and obstructive cholangiopathy in biliary atresia: Association with biliary innate immunity. (conference：ISSBA シンポジウム2 Etiology and Pathophysiology)(2017/05/12)
- Classification of intrahepatic cholangiocarcinoma microenvironment based on immune cell and tumor stromal features(conference：EASL)(2019/04/11)
- Molecular mechanism of cholangiopathy in PBC(2019)
- Clinical features of cystatin A expression in patients with pancreatic ductal adenocarcinoma(2019/07/12)
- IDENTIFICATION OF NOVEL BILIARY EPITHELIAL CELL BIOMARKERS IN PRIMARY BILIARY CHOLANGITIS(PBC)(conference：The Liver Meeting 2019)(2019/11/08)
- EFFICACY AND SAFETY OF E6011,ANTI-HUMAN FRACTALKINE MONOCLONAL ANTIBODY, INPATIENTS WITH PRIMARY BILIARY CHOLANGITIS WITH AN INCOMPLETE RESPONSE TO URSODEOXYCHOLIC ACID:A PLACEBO-CONTROLLED DOUBLE-BLIND COMPARISON PHESE 2 STUDY(conference：The Liver Meeting 2019)(2019/11/08)
- The essence of the bile ductular carcinoma from the viewpoint of surgeon(2017/07/06)
- CT findings of cholangiolocellular carcinoma in comparison with those of HCC and CCC(2017/07/06)
- Imatinib Induces Apoptosis of NK/T Cell Neoplasms by Inhibitiong Hematopoietic Cell Kinase and NQO2 (conference：ASH （AMERICAN SOCIETY OF HEMATOLOGY）59th Annual meeting 2017)(2017/12/09)
- Increased expression and altered localization of cathepsis Z is associated with progression to jaundice-stage in primary biliary cholangitis (conference：AASLD The Liver Meeting 2017)(2017/10/20)
- A cute presentation ofo autoimmune hepatitis in adults and children: histological Spectrum and features distinguishing it from drug-induced liver injury and acute Viral hepatitis.(2017/10/20)
- Immune-mediated cystatin A expression in patients with pancreatic Ductal adenocarcinoma(conference：ESMO Immuno Oncology Congress 2017)(2017/12/07)
- Pathology Update 「Recent Pathological Concept of Pancreaticobiliary Diseases」(conference：第７４回日本医学放射線学会総会「Pathology Update 胆・膵」)(2015/04/18)
- Cholangiocarcinoma with respect IgG4 Reaction(conference：IAP)(2014/10/05)
- IgG4 reaction in biliary intraepithelial neoplasia and cholangiocarcinoma arising from sclerosing cholangitis(conference：The 102nd USCAP ANNUAL MEETING)(2013/03/02)
- Energy metabolic change induced by ERRα-PGC-1α axis in chronic non-suppurative destructive cholangitis of primary biliary cirrhosis(conference：The 102nd USCAP ANNUAL MEETING)(2013/03/02)
- Pathological Differences between IgG4-Related Sclerosing Cholangitis with and without Autoimmune Pancreatitis(conference：The 102nd USCAP ANNUAL MEETING )(2013/03/02)
- Alteration of energy metabolism and subsequent oxidative stress in the pathogenesis of cholangiopathy in primary biliary cirrhosis (conference：The Liver Meeting 2013)(2013/11/01)
- Clinicopathological significance of serum fractalkine and its regulation by ursodeoxycholic acid in primary biliary cirrhosis (conference：The Liver Meeting 2013 )(2013/11/01)
Others
- Molecular mechanisms of cholangiopathy in primary biliary cirrhosis. Nakanuma Y 2006
- Intrahepatic bile duct loss in immune-mediated ductopenic biliary diseases with an emphasis on biliary epithelial apoptosis. Nakanuma Y 2003
- Endotoxin tolerance in human intrahepatic biliary epithelial cells is induced by upregulation of IRAK-M 2006
- Interferon-gamma accelerates NF-kappaB activation of biliary epithelial cells induced by Toll-like receptor and ligand interaction. 2006
- Molecular mechanisms of cholangiopathy in primary biliary cirrhosis. 39(2):55-61 2006//2
- Molecular mechanisms of cholangiopathy in primary biliary cirrhosis. 39(2) 55-61 2006/02
- Endotoxin tolerance in human intrahepatic biliary epithelial cells is induced by upregulation of IRAK-M. 26(8):935-42 2006/10
- Biliary innate immunity and cholangiopathy. 3:S430-7 2007/10
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○2022「免疫チェックポイント阻害薬による肝障害の病理学的病態解明」(2020-2022)
○「難治性の肝・胆道疾患に関する調査研究」(2017-2019)
○「肝細胞癌の分子・遺伝子的亜分類に基づいたradiogenomics」(2017-2019)
○「原発性胆汁性胆管炎模倣培養系からのゲノム・脂質情報を利用した新規治療法の開発」(2017-2019)
○「包括的１細胞遺伝子解析法を用いた自己免疫性肝疾患の病理学的解析」(2017-2019)
○「肝内胆管癌の遺伝子・分子生物学的機構に基づいたイメージバイオマーカーの研究」(2016-2018)
○「小児期発症の希少難治性肝胆膵疾患における包括的な診断・治療ガイドライン作成に関する研究」(2014-2015)
○「Ｃ型肝炎ウイルスに起因する肝硬変に対する抗線維化治療薬の開発に関する研究」(2013-2015)
○「胆道閉鎖症の病態解明－胆道系自然免疫から獲得免疫への連携と自己免疫現象の解析」(2008-2010)
○「原発性胆汁性肝硬変の胆管細胞アポトーシスにおける自然免疫の関与」(2007-2007)
○「原発性胆汁性肝硬変の胆管細胞アポトーシスにおける自然免疫の関与」(2007-2007)
○「原発性胆汁性肝硬変の胆管細胞アポトーシスにおける自然免疫の関与」(2006-2006)
○「原発性胆汁性肝硬変の肝内胆管細胞培養株の樹立と病態解析への応用」(2005-2005)
○「原発性胆汁性肝硬変の肝内胆管細胞培養株の樹立と病態解析への応用」(2004-2004)
○「原発性胆汁性肝硬変における肝内胆管破壊の分子機構」(2003-2003)
○「原発性胆汁性肝硬変における肝内胆管破壊の分子機構」(2002-2002)
○「原発性胆汁性肝硬変の肝組織内における疾患特異的抗原成分の検出の試み」(1998-1998)
○「原発性胆汁性肝硬変の肝組織内における疾患特異的抗原成分の検出の試み」(1997-1998)
○「原発性胆汁性肝硬変の胆管病変におけるエネルギー代謝の解析と治療戦略」(2014-2016)
○「原発性胆汁性肝硬変の胆管病変における性ホルモンの関与と治療戦略」(2011-2013)
○「胆道閉鎖症の病態解明－胆道系自然免疫から獲得免疫への連携と自己免疫現象の解析」(2009-2010)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Human Pathology 1(2022)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＡ(2022)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＡ(2022)
○Human Pathology 1(2022)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＡ(2022)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＡ(2022)
○Human Pathology 2(2022)
○Academic Skills(2022)
○Human Pathology 2(2022)
○Basic Health Science 1(2022)
○Basic Health Science 2(2022)
○Human Pathology 2(2022)
○Human Pathology 2(2022)
○Human Pathology2(2019)
○Freshman Seminar I(2019)
○Basic Health Science(2019)
○Freshman Seminar I(2018)
○Human Pathology2(2018)
○Basic Health Science(2018)
○Human Pathology(2017)
○Freshman Seminar I(2017)
○Basic Health Science(2017)
○Human Pathology(2016)
○Freshman Seminar I(2016)
○Human Pathology(2016)
○Basic Health Science(2016)
Classes (Graduate Schools)
○Human Pathology(2022)
○Human Pathology(2022)
○Morpho-Functional Pathology(2022)
○Morpho-Functional Pathology(2022)
○Human Pathology(2022)
○Human Pathology(2022)
○Morpho-Functional Pathology(2022)
○Morpho-Functional Pathology(2022)
○Medical Sciences(2022)
○Human Pathology(2022)
○Human Pathology(2022)
○Morpho-Functional Pathology(2022)
○Morpho-Functional Pathology(2022)
○Introduction to Basic Medical Science(2022)
○Human Pathology(2022)
○Human Pathology(2022)
○Morpho-Functional Pathology(2022)
○Morpho-Functional Pathology(2022)
○Introduction to Basic Medical Science(2022)
○Human Body: Diseases(2022)
○Pathology and Pathogenesis(2022)
○Medical Sciences(2017)
○Pathology and Pathogenesis(2017)
○Morpho-Functional Pathology(2017)
○Morpho-Functional Pathology(2017)
○Morpho-Functional Pathology(2017)
○Introduction to Basic Medical Science(2016)
○Morpho-Functional Pathology(2016)
○Morpho-Functional Pathology(2016)
○Pathology and Pathogenesis(2016)
○Morpho-Functional Pathology(2016)