last modified：2025/04/08
Associate Professor YOSHIOKA Kazuaki
Faculty, Affiliation
Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences
Associate Professor
College and School Educational Field
Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
Laboratory
Department of Vasucular Molecular Physiology TEL:076-265-2166 FAX:076-234-4223
Academic Background
【Academic background(Doctoral/Master's Degree)】
Tokyo University of Agriculture and Technology Doctor Graduate School, Division of Engineering Molecular Biotechnology 199803 Completed
【Academic background(Bachelor's Degree)】
Tokyo University of Agriculture and Technology Industrial Chemistry 199603
Career
Tokyo Metropolitan Institute for Neuroscience Molecular and Cellular Neurobiology(1999/10/01-2002/04/01)
Bioanalytical Systems, Inc. Microdialysis(1998/04/01-1999/09/30)
Year & Month of Birth
1969/04
Academic Society
Award
○Young Investigator Award(2006/12/01)
○Mitsubishi Pharma Research Foundation(2004)
Specialities
General physiology
Speciality Keywords
PI3 kinase,Autophagy,Endocytosis,Membrane Trafficking,Signal transduction,contruction-relaxation Smooth muscle cell,Cardiovascular remodeling,Angiogenesis
Research Themes
Single-cell RNA-sequence analysis of adventitial vasa vasorum in human aortic dissection.
Study of physiological role of cardiovascular remodeling using knockout mouse.
Regulation of Pulmonary stem cell function through intracellular clearance.
Regulation of contraction of vascular smooth muscle cells by mechanical stimulus
Books
- Role of sphingosine-1-phosphate signaling in atherosclerosis John Wiley & Sons 2011/01
- Sphingosine-1-phosphate regulation of macrophages in atherosclerosis Springer 2011/01
Papers
- Synthesis and structure-activity relationships of selective ligands for P3 purinoceptor-like protein (P3LP) Nucleic Acids Symposium Series 44 19-20 2000
- Effects of melatonin administration on the release of endogenous 5-HT and its metabolite in rat SCN Yoshioka, K., Xie, F., Gitzen, J., Kissinger, C. and Kissinger, P Asian J. Drug Metabolism & Pharmacokinetics 3 265-272 2003/01
- Rho-dependent, Rho kinase-independent inhibitory regulation of Rac and cell migration by LPA1 receptor in Gi-inactivated CHO cells. Sugimoto, N., Takuwa, N., Yoshioka, K. and Takuwa, Y. EXPERIMENTAL CELL RESEARCH 312 1899-1908 2006/01
- Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system. Takuwa Y, Okamoto Y, Yoshioka K, Takuwa N. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1781 483-488 2008/01
- Roles of sphingosine-1-phosphate signaling in angiogenesis. Y Takuwa, W Du, X Qi, Y Okamoto, N Takuwa, K Yoshioka. World J Biol Chem. 1 10 298-306 2010/01
- Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in Apoe-deficient mice. JOURNAL OF CLINICAL INVESTIGATION 120 3979-3995 2010/01
- S1P(2), the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice. Du W, Takuwa N, Yoshioka K, Okamoto Y, Gonda K, Sugihara K, Fukamizu A, Asano M, Takuwa Y. CANCER RESEARCH 70 772-781 2010/01
- Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice. Xun Qi, Yasuo Okamoto, Tomomi Murakawa, Fei Wang, Osamu Oyama, Ryunosuke Ohkawa, Kazuaki Yoshioka, Wa Du, Naotoshi Sugimoto, Yutaka Yatomi, Noriko Takuwa, Yoh Takuwa EUROPEAN JOURNAL OF PHARMACOLOGY 634 121-131 2010/01
- Sphingosine-1-phosphate signaling and cardiac fibrosis. Inflammation & Regeneration 33 2 96-108 2013/01
- Sphingoshine-1-phospahte as a mediator involved in development of fibrotic diseases. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1831 185-192 2013/01
- Sphingosine-1-phosphate receptor-2 protects against anaphylactic shock through suppression of eNOS in mice. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 132 5 1205-1214 2013
- Class II PI3 kinase C2 alpha has an essential role in angiogenesis and vascular homeostasis through regulating endosomal trafficking Yoshioka, Kazuaki;Takuwa, Noriko;Okamoto, Yasuo;Takuwa, Yoh JOURNAL OF PHYSIOLOGICAL SCIENCES 63 0 S98-S98 2013
- Class II PI3 kinase-C2 alpha plays essential roles in endosomal Rac1 activation and cell migration in S1P-stimulated endothelial cells Biswas, Kuntal;Yoshioka, Kazuaki;Aki, Sho;Cui Hong;Zhao JuanJuan;Kuda, Yuichi;Takuwa, Noriko;Okamoto, Yasuo;Takuwa, Yoh JOURNAL OF PHYSIOLOGICAL SCIENCES 63 0 S136-S136 2013
- Sphingosine-1-phosphate receptor-2 plays a protective role against anaphylactic shock through inhibiting eNOS Cui Hong;Okamoto, Yasuo;Yoshioka, Kazuaki;Du Wa;Takuwa, Noriko;Zhang Wei;Biswas, Kuntal;Aki, Sho;Zhao JuanJuan;Kuda, Yuichi;Asano, Masahide;Shibamoto, Toshishige;Takuwa, Yoh JOURNAL OF PHYSIOLOGICAL SCIENCES 63 0 S119-S119 2013
- Disruption of sphingosine-1-phosphate receptor-2 gene inhibits atherosclerosis in apoE-deficient mice Wang, Fei;Okamoto, Yasuo;Inoki, Isao;Yoshioka, Kazuaki;Takuwa, Noriko;Takuwa, Yoh JOURNAL OF PHARMACOLOGICAL SCIENCES 115 0 97P-97P 2011
- [Physiological roles of class II PI3 kinase-C2alpha in endothelial cells]. Yoshioka, Kazuaki; Takuwa, Noriko; Okamoto, Yasuo; Takuwa, Yoh Seikagaku. The Journal of Japanese Biochemical Society 85 9 775-780 2013/09/01
- Cardiovascular function of sphingosine 1-phosphate signaling Okamoto, Yasuo; Yoshioka, Kazuaki; Takuwa, Noriko; Takuwa, Yoh Seikagaku 83 6 536-544 2011/12/01
- G protein-coupled sphingosine-1-phosphate receptors: Potential molecular targets for angiogenic and anti-angiogenic therapies Takuwa, Noriko; Okamoto, Yasuo; Yoshioka, Kazuaki; Takuwa, Yoh Biomedical Reviews 22 15-29 2011/12/01
- Enhanced Ca2+-Dependent Activation of Phosphoinositide 3-Kinase Class IIα Isoform-Rho Axis in Blood Vessels of Spontaneously Hypertensive Rats. HYPERTENSION 56 934-941 2010/01
- Pharmacology of a unique adenosine binding site in rat brain using a selective ligand K Yoshioka,A Matsuda,H Nakata CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 28 4 278 2001/04
- Hetero-oligomerization between adenosine A
1 and P2Y1 receptors in living cells: Formation of ATP-sensitive adenosine receptors Nakata, H.,Yoshioka, K.,Saitoh, O. Drug Development Research 58 4 340 2003/05 - Purinergic-receptor oligomerization: Implications for neural functions in the central nervous system H Nakata,K Yoshioka,T Kamiya NEUROTOXICITY RESEARCH 6 4 291 2004
- Hetero-oligomerization of adenosine A(1) receptors with P2Y(1) receptors in rat brains K Yoshioka,R Hosoda,Y Kuroda,H Nakata FEBS LETTERS 531 2 299 2002/11
- Heteromeric association creates a P2Y-like adenosine receptor K Yoshioka,O Saitoh,H Nakata PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98 13 7617 2001/06
- A novel fluorescent derivative of glucose applicable to the assessment of glucose uptake activity of Escherichia coli K Yoshioka,H Takahashi,T Homma,M Saito,KB Oh,Y Nemoto,H Matsuoka BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1289 1 5 1996/02
- Determination of melatonin in commercially available products by LCEC and LC/MS/MS FM Xie,P Wong,K Yoshioka,RG Cooks,PT Kissinger JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES 21 9 1273 1998
- Oligomerization of adenosine A(2A) and dopamine D-2 receptors in living cells T Kamiya,O Saitoh,K Yoshioka,H Nakata BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 306 2 544 2003/06
- Calcium-dependent regulation of Rho and myosin phosphatase in vascular smooth muscle Yoh Takuwa,Kazuaki Yoshioka,Noriko Takuwa,Yu Wang,Mohammed Ali Azam,Naotoshi Sugimoto Biomedical Reviews 16 13 2005 ?
- Functions of heteromeric association between adenosine and P2Y receptors H Nakata,K Yoshioka,T Kamiya,H Tsuga,K Oyanagi JOURNAL OF MOLECULAR NEUROSCIENCE 26 2-3 233 2005
- Agonist-promoted heteromeric oligomerization between adenosine A(1) and P2Y(1) receptors in living cells K Yoshioka,O Saitoh,H Nakata FEBS LETTERS 523 1-3 147 2002/07
- Nucleosides and nucleotides. 200. Reinvestigation of 5 '-N-ethylcarboxamidoadenosine derivatives: Structure-activity relationships for P-3 purinoceptor-like proteins T Umino,K Yoshioka,Y Saitoh,N Minakawa,H Nakata,A Matsuda JOURNAL OF MEDICINAL CHEMISTRY 44 2 208 2001/01
- In vivo microdialysis liquid chromatography tandem mass spectrometry for the on-line monitoring of melatonin in rat PSH Wong,K Yoshioka,F Xie,PT Kissinger RAPID COMMUNICATIONS IN MASS SPECTROMETRY 13 5 407 1999
- Evaluation of 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose, a new fluorescent derivative of glucose, for viability assessment of yeast Candida albicans K Yoshioka,KB Oh,M Saito,Y Nemoto,H Matsuoka APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 46 4 400 1996/11
- Intracellular fate of 2-NBDG, a fluorescent probe for glucose uptake activity, in escherichia coli cells Kazuaki Yoshioka,Mikako Saito,Ki-Bong Oh,Yasuyuki Nemoto,Hideaki Matsuoka,Masahiro Natsume,Hiroshi Abe Bioscience, Biotechnology and Biochemistry 60 11 1899 1996
- Analysis of olfactory function of the silkworm bombyx mori Yoshioka, K.,Homma, T.,Matsuoka, H. Electrochemistry 64 11 1138 1996
- ATP- and adenosine-mediated signaling in the central nervous system: Purinergic receptor complex: Generating adenine nucleotide-sensitive adenosine receptors K Yoshioka,H Nakata JOURNAL OF PHARMACOLOGICAL SCIENCES 94 2 88 2004/02
- Development of a novel fluorescent glucose and its application to probe for cell metabolic activity YOSHIOKA Kazuaki Doctoral Thesis (Tokyo University of Agriculture and Technology) 12605甲博工第140号 1997/03
- Essential role for class II phosphoinositide 3-kinase α-isoform in Ca2+-induced, Rho- and Rho kinase-dependent regulation of myosin phosphatase and contraction in isolated vascular smooth muscle cells Kazuaki Yoshioka,Naotoshi Sugimoto,Noriko Takuwa,Yoh Takuwa Molecular Pharmacology 71 3 912 2007/03
- G protein-coupled sphingosine-1-phosphate receptors: Potential molecular targets for angiogenic and anti-angiogenic therapies Noriko Takuwa,Yasuo Okamoto,Kazuaki Yoshioka,Yoh Takuwa Biomedical Reviews 22 15 2011
- Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice Xun Qi,Yasuo Okamoto,Tomomi Murakawa,Fei Wang,Osamu Oyama,Ryunosuke Ohkawa,Kazuaki Yoshioka,Wa Du,Naotoshi Sugimoto,Yutaka Yatomi,Noriko Takuwa,Yoh Takuwa EUROPEAN JOURNAL OF PHARMACOLOGY 634 1-3 121 2010/05
- Rho-dependent, Rho kinase-independent inhibitory regulation of Rac and cell migration by LPA(1) receptor in G(i)-inactivated CHO cells N Sugimoto,N Takuwa,K Yoshioka,Y Takuwa EXPERIMENTAL CELL RESEARCH 312 10 1899 2006/06
- Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice Hong Cui,Yasuo Okamoto,Kazuaki Yoshioka,Wa Du,Noriko Takuwa,Wei Zhang,Masahide Asano,Toshishige Shibamoto,Yoh Takuwa Journal of Allergy and Clinical Immunology 132 5 1205 2013/11
- S1P(3)-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species Noriko Takuwa,Sei-Ichiro Ohkura,Shin-Ichiro Takashima,Keisuke Ohtani,Yasuo Okamoto,Tamotsu Tanaka,Kaoru Hirano,Soichiro Usui,Fei Wang,Wa Du,Kazuaki Yoshioka,Yoshiko Banno,Motoko Sasaki,Ikuyo Ichi,Miwa Okamura,Naotoshi Sugimoto,Kiyomi Mizugishi,Yasuni Nakanuma,Isao Ishii,Masayuki Takamura,Shuichi Kaneko,Shosuke Kojo,Kiyoshi Satouchi,Kunitoshi Mitumori,Jerold Chun,Yoh Takuwa CARDIOVASCULAR RESEARCH 85 3 484 2010/02
- Aldosterone inhibits endothelial morphogenesis and angiogenesis through the downregulation of vascular endothelial growth factor receptor-2 expression subsequent to peroxisome proliferator-activated receptor gamma Miki Fujii,Isao Inoki,Makoto Saga,Norihiro Morikawa,Ken-ichiro Arakawa,Satoru Inaba,Kazuaki Yoshioka,Tadashi Konoshita,Isamu Miyamori JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 129 3-5 145 2012/04
- The role of class II PI 3-kinase signaling pathway in physiology and diseases. Curr Biodata Targeted Proteins Database. Takuwa Y,yoshioka K,Okamoto Y,Takuwa N Current Biodata. Targeted Proteins database 1 2009
- Sphingosine-1-phosphate as a mediator involved in development of fibrotic diseases Yoh Takuwa,Hitoshi Ikeda,Yasuo Okamoto,Noriko Takuwa,Kazuaki Yoshioka BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1831 1 185 2013/01
- Sphingosine-1-Phosphate Signaling and Cardiac Fibrosis. Takuwa N,Okamoto Y,Yoshioka K,Takuwa Y Inflammation and Regeneration 33 2 96 2013
- Vascular endothelial S1P 2 receptor limits tumor angiogenesis and hyperpermeability Noriko Takuwa,Yasuo Okamoto,Kazuaki Yoshioka,Yoh Takuwa Bioactive Lipid Mediators: Current Reviews and Protocols 237 2015/01/01
- Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system Yoh Takuwa,Yasuo Okamoto,Kazuaki Yoshioka,Noriko Takuwa BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1781 9 483 2008/09
- Roles of sphingosine-1-phosphate signaling in angiogenesis. Takuwa Y,Du W,Qi X,Okamoto Y,Takuwa N,Yoshioka K World J Biol Chem. 1 10 298 2010
- Class II phosphoinositide 3-kinase alpha-isoform regulates Rho, myosin phosphatase and contraction in vascular smooth muscle Y Wang,K Yoshioka,MA Azam,N Takuwa,S Sakurada,Y Kayaba,N Sugimoto,Inoki, I,T Kimura,T Kuwaki,Y Takuwa BIOCHEMICAL JOURNAL 394 3 581 2006/03
- Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 Noriko Takuwa,Wa Du,Erika Kaneko,Yasuo Okamoto,Kazuaki Yoshioka,Yoh Takuwa AMERICAN JOURNAL OF CANCER RESEARCH 1 4 460 2011
- Sphingosine-1-phosphate as a mediator involved in development of fibrotic diseases Takuwa, Y.,Ikeda, H.,Okamoto, Y.,Takuwa, N.,Yoshioka, K. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1831 1 185 2013/01
- Essential Role of Class II Phosphatidylinositol-3-kinase-C2 alpha in Sphingosine 1-Phosphate Receptor-1-mediated Signaling and Migration in Endothelial Cells Kuntal Biswas,Kazuaki Yoshioka,Ken Asanuma,Yasuo Okamoto,Noriko Takuwa,Takehiko Sasaki,Yoh Takuwa JOURNAL OF BIOLOGICAL CHEMISTRY 288 4 2325 2013/01
- Overexpression of Sphingosine Kinase 1 Prevents Ceramide Accumulation and Ameliorates Muscle Insulin Resistance in High-Fat Diet-Fed Mice Clinton R. Bruce,Steve Risis,Joanne R. Babb,Christine Yang,Greg M. Kowalski,Ahrathy Selathurai,Robert S. Lee-Young,Jacquelyn M. Weir,Kazuaki Yoshioka,Yoh Takuwa,Peter J. Meikle,Stuart M. Pitson,Mark A. Febbraio DIABETES 61 12 3148 2012/12
- Endothelial PI3K-C2 alpha, a class II PI3K, has an essential role in angiogenesis and vascular barrier function Kazuaki Yoshioka,Kotaro Yoshida,Hong Cui,Tomohiko Wakayama,Noriko Takuwa,Yasuo Okamoto,Wa Du,Xun Qi,Ken Asanuma,Kazushi Sugihara,Sho Aki,Hidekazu Miyazawa,Kuntal Biswas,Chisa Nagakura,Masaya Ueno,Shoichi Iseki,Robert J. Schwartz,Hiroshi Okamoto,Takehiko Sasaki,Osamu Matsui,Masahide Asano,Ralf H. Adams,Nobuyuki Takakura,Yoh Takuwa NATURE MEDICINE 18 10 1560 2012/10
- S1P(2), the G Protein-Coupled Receptor for Sphingosine-1-Phosphate, Negatively Regulates Tumor Angiogenesis and Tumor Growth In vivo in Mice Wa Du,Noriko Takuwa,Kazuaki Yoshioka,Yasuo Okamoto,Koichi Gonda,Kazushi Sugihara,Akiyoshi Fukamizu,Masahide Asano,Yoh Takuwa CANCER RESEARCH 70 2 772 2010/01
- G(12/13) and G(q) mediate S1P(2)-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase Shin-ichiro Takashima,Naotoshi Sugimoto,Noriko Takuwa,Yasuo Okamoto,Kazuaki Yoshioka,Masayuki Takamura,Shigeo Takata,Shuichi Kaneko,Yoh Takuwa CARDIOVASCULAR RESEARCH 79 4 689 2008/09
- Negative regulation of endothelial morphogenesis and angiogenesis by S1P(2) receptor Inoki, I,N Takuwa,N Sugimoto,K Yoshioka,S Takata,S Kaneko,Y Takuwa BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 346 1 293 2006/07
- Sphingosine-1-phosphate signaling in physiology and diseases Yoh Takuwa,Yasuo Okamoto,Kazuaki Yoshioka,Noriko Takuwa BIOFACTORS 38 5 329 2012/09
- Sphingosine-1-phosphate-specific G protein-coupled receptors as novel therapeutic targets for atherosclerosis Yasuo Okamoto,Fei Wang,Kazuaki Yoshioka,Noriko Takuwa,Yoh Takuwa Pharmaceuticals 4 1 117 2011
- Enhanced Ca2+-Dependent Activation of Phosphoinositide 3-Kinase Class II alpha Isoform-Rho Axis in Blood Vessels of Spontaneously Hypertensive Rats Young Mi Seok,Mohammed Ali Azam,Yasuo Okamoto,Atsushi Sato,Kazuaki Yoshioka,Masataka Maeda,InKyeom Kim,Yoh Takuwa HYPERTENSION 56 5 934 2010/11
- S1P 3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species Noriko Takuwa,Sei-Ichiro Ohkura,Shin-Ichiro Takashima,Keisuke Ohtani,Yasuo Okamoto,Tamotsu Tanaka,Kaoru Hirano,Soichiro Usui,Fei Wang,Wa Du,Kazuaki Yoshioka,Yoshiko Banno,Motoko Sasaki,Ikuyo Ichi,Miwa Okamura,Naotoshi Sugimoto,Kiyomi Mizugishi,Yasuni Nakanuma,Isao Ishii,Masayuki Takamura,Shuichi Kaneko,Shosuke Kojo,Kiyoshi Satouchi,Kunitoshi Mitumori,Jerold Chun,Yoh Takuwa Cardiovascular Research 85 3 484 2010/02
- Ca2+-independent, inhibitory effects of cyclic adenosine 5 '-monophosphate on Ca2+ regulation of phosphoinositide 3-kinase c2 alpha, Rho, and myosin phosphatase in vascular smooth muscle Mohammed Ali Azam,Kazuaki Yoshioka,Shinsuke Ohkura,Noriko Takuwa,Naotoshi Sugimoto,Koichi Sato,Yoh Takuwa JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 320 2 907 2007/02
- Early endothelialization associated with a biolimus A9 bioresorbable polymer stent in a porcine coronary model Masayuki Mori,Kenji Sakata,Chiaki Nakanishi,Takuya Nakahashi,Masa-aki Kawashiri,Kazuaki Yoshioka,Yoh Takuwa,Hirofumi Okada,Jun-ichiro Yokawa,Masaya Shimojima,Tsuyoshi Yoshimuta,Shohei Yoshida,Masakazu Yamagishi,Kenshi Hayashi HEART AND VESSELS 32 10 1244 2017/10
- Adipose-Derived Stem Cell Sheets Promote Meniscus Regeneration Regardless of Whether the Defect Involves the Inner Half or the Whole Width of the Anterior Half of the Medial Meniscus in a Rabbit Model Kazuki Asai,Junsuke Nakase,Kazuaki Yoshioka,Rikuto Yoshimizu,Mitsuhiro Kimura,Hiroyuki Tsuchiya Arthroscopy 38 9 2672 2022/09
- Lysophosphatidic acid-induced YAP/TAZ activation promotes developmental angiogenesis by repressing Notch ligand Dll4 Yasuda Daisuke,Kobayashi Daiki,Akahoshi Noriyuki,Ohto-Nakanishi Takayo,Yoshioka Kazuaki,Takuwa Yoh,Mizuno Seiya,Takahashi Satoru,Ishii Satoshi JOURNAL OF CLINICAL INVESTIGATION 129 10 4332 2019/10
- TGFβ receptor endocytosis and Smad signaling require synaptojanin1, PI3K-C2α-, and INPP4B-mediated phosphoinositide conversions. Sho Aki,Kazuaki Yoshioka,Noriko Takuwa,Yoh Takuwa Molecular biology of the cell 31 5 360 2020/03/01
- The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery Kiren Baines,Kazuaki Yoshioka,Yoh Takuwa,Jon D. Lane Autophagy Reports 1 1 88 2021/12/31
- Class II phosphatidylinositol 3-kinase-C2α is essential for Notch signaling by regulating the endocytosis of γ-secretase in endothelial cells Shota Shimizu,Kazuaki Yoshioka,Sho Aki,Yoh Takuwa Scientific Reports 11 1 2021/12
- Class II phosphatidylinositol 3-kinase isoforms in vesicular trafficking Kazuaki Yoshioka Biochemical Society Transactions 49 2 893 2021/04/30 ?
- Class II phosphatidylinositol 3-kinase α and β isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice. Shahidul Islam,Kazuaki Yoshioka,Sho Aki,Kazuhiro Ishimaru,Hiroki Yamada,Noriko Takuwa,Yoh Takuwa The journal of physiological sciences : JPS 70 1 18 2020/03/19
- Everolimus-Eluting Biodegradable Abluminal Coating Stent versus Durable Conformal Coating Stent: Termination of the Inflammatory Response Associated with Neointimal Healing in a Porcine Coronary Model. Masayuki Mori,Kenji Sakata,Junichiro Yokawa,Chiaki Nakanishi,Kota Murai,Hirofumi Okada,Masaya Shimojima,Shohei Yoshida,Kazuaki Yoshioka,Yoh Takuwa,Kenshi Hayashi,Masakazu Yamagishi,Masa-Aki Kawashiri Journal of interventional cardiology 2020 8 1956015 2020
- Sphingosine kinase-2 prevents macrophage cholesterol accumulation and atherosclerosis by stimulating autophagic lipid degradation Ishimaru K,Yoshioka K,Kano K,Kurano M,Saigusa D,Aoki J,Yatomi Y,Takuwa N,Okamoto Y,Proia R,Takuwa Y SCIENTIFIC REPORT 9 1 13829 2019/12
- Class II PI3Ks α and β Are Required for Rho-Dependent Uterine Smooth Muscle Contraction and Parturition in Mice Md Azadul Kabir Sarker,Sho Aki,Kazuaki Yoshioka,Kouji Kuno,Yasuo Okamoto,Kazuhiro Ishimaru,Noriko Takuwa,Yoh Takuwa Endocrinology 160 1 235 2019/01/01
- Photoacoustic imaging of tumour vascular permeability with indocyanine green in a mouse model. Kenichiro Okumura,Kotaro Yoshida,Kazuaki Yoshioka,Sho Aki,Norihide Yoneda,Dai Inoue,Azusa Kitao,Takahiro Ogi,Kazuto Kozaka,Tetsuya Minami,Wataru Koda,Satoshi Kobayashi,Yoh Takuwa,Toshifumi Gabata European radiology experimental 2 1 5 2018
- Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6 Sei-ichiro Ohkura,Soichiro Usui,Shin-ichiro Takashima,Noriko Takuwa,Kazuaki Yoshioka,Yasuo Okamoto,Yutaka Inagaki,Naotoshi Sugimoto,Teppei Kitano,Masayuki Takamura,Takashi Wada,Shuichi Kaneko,Yoh Takuwa PLOS ONE 12 8 e0182329 2017/08
- Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling Ioannis Serafimidis,Eva Rodriguez-Aznar,Mathias Lesche,Kazuaki Yoshioka,Yoh Takuwa,Andreas Dahl,Duojia Pan,Anthony Gavalas PLOS BIOLOGY 15 3 2017/03
- Analysis of various types of single-polypeptide-chain (sc) heterodimeric A(2A)R/D2R complexes and their allosteric receptor receptor interactions Toshio Kamiya,Kazuaki Yoshioka,Hiroyasu Nakata BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 456 2 573 2015/01
- MTMR4, a phosphoinositide‐specific 3’‐phosphatase, regulates TFEB activity and the endocytic and autophagic pathways Hoa Q. Pham,Kazuaki Yoshioka,Hiromi Mohri,Hiroki Nakata,Sho Aki,Kazuhiro Ishimaru,Noriko Takuwa,Yoh Takuwa Genes to Cells 23 8 670 2018/08
- Suppression of androgen receptor signaling induces prostate cancer migration via activation of the CCL20–CCR6 axis Kano, Hiroshi,Izumi, Kouji,Hiratsuka, Kaoru,Toriumi, Ren,Nakagawa, Ryunosuke,Aoyama, Shuhei,Kamijima, Taiki,Shimada, Takafumi,Naito, Renato,Kadomoto, Suguru,Iwamoto, Hiroaki,Yaegashi, Hiroshi,Kawaguchi, Shohei,Nohara, Takahiro,Shigehara, Kazuyoshi,Kadono, Yoshifumi,Saito, Yohei,Nakagawa-Goto, Kyoko,Yoshioka, Kazuaki,Nakata, Hiroki,Lin, Wen-Jye,Mizokami, Atsushi Cancer Science 114 4 1479 2023/04
- The class II phosphoinositide 3-kinases PI3K-C2α and PI3K-C2β differentially regulate clathrin-dependent pinocytosis in human vascular endothelial cells Aung, K.T.,Yoshioka, K.,Aki, S.,Ishimaru, K.,Takuwa, N.,Takuwa, Y. Journal of Physiological Sciences 69 2 263 2019/03
- LPA-induced YAP/TAZ activation promotes developmental angiogenesis by regulating Dll4 expression Yasuda D,Kobayashi D,Akahoshi N,Ohto-Nakanishi T,Yoshioka K,Takuwa Y,Mizuno S,Takahashi S,Ishii S J Clin Invest 129 10 4332 2019
- Sphigosine-1-phosphate receptor 1 promotes neointimal hyperplasia in a mouse model of carotid artery injury. Teppei Kitano,Soichiro Usui,Shin-Ichiro Takashima,Oto Inoue,Chiaki Goten,Ayano Nomura,Kazuaki Yoshioka,Masaki Okajima,Shuichi Kaneko,Yoh Takuwa,Masayuki Takamura Biochemical and biophysical research communications 511 1 179 2019/03/26
- Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages Juanjuan Zhao,Yasuo Okamoto,Yuya Asano,Kazuhiro Ishimaru,Sho Aki,Kazuaki Yoshioka,Noriko Takuwa,Takashi Wada,Yutaka Inagaki,Chiaki Takahashi,Takumi Nishiuchi,Yoh Takuwa PLoS ONE 13 5 e0197604 2018/05/01
- Phosphatidylinositol 3-Kinase Class II alpha-Isoform PI3K-C2 alpha Is Required for Transforming Growth Factor beta-induced Smad Signaling in Endothelial Cells Sho Aki,Kazuaki Yoshioka,Yasuo Okamoto,Noriko Takuwa,Yoh Takuwa JOURNAL OF BIOLOGICAL CHEMISTRY 290 10 6086 2015/03
- Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice (Journal of Clinical Investigation (2010) 120, 11, (3979-3995) DOI:10.1172/JCI42315) Wang F,Okamoto Y,Inoki I,Yoshioka K,Du W,Qi X,Takuwa N,Gonda K,Yamamoto Y,Ohkawa R,Nishiuchi T,Sugimoto N,Yatomi Y,Mitsumori K,Asano M,Kinoshita M,Takuwa Y Journal of Clinical Investigation 122 3 1131 2012/03
- Differences in Collagen Types in the Semitendinosus, Quadriceps, and Patellar Tendons: The Report Using Samples from the Same Individual. Yushin Mizuno, Junsuke Nakase, Kazuaki Yoshioka, Takuya Sengoku, Rikuto Yoshimizu, Tomoyuki Kanayama, Yusuke Yanatori, Hiroyuki Tsuchiya The Knee in press 2023
Conference Presentations
- Essential role of class II PI3K in endocytosis and endosomal signaling(conference：9th Federation of the Asia and Oceanian Physiological Societies (FAOPS2019) )(2019/03/28)
- Class II phosphoinositide 3-kinase isoforms PI3K-C2α and PI3K-C2β play essential roles in pinocytosis in vascular endothelial cells(2018/03/28)
- Indispensable role of α and β isoforms of class II phosphoinositide 3-kinases (PI3K) in the uterine smooth muscle contraction during labor(2018/03/28)
- Myotubularin-related protein 4 (MTMR4), a phosphoinositide 3'-phosphatase, regulates endolysosome integrity and autophagy flux in human lung alveolar epithelial A549 cells(2018/03/28)
- Endothelial Class II PI3K-C2α is necessary for vascular formation and integrity through regulating endocytic membrane trafficking(2017/03/18)
- PI3K-C2α is required for TGFβ-induced receptor endocytosis and endosomal signaling in endothelial cells.(2016/03/24)
- Sphingosine 1-phosohate receptor-2 plays a protective role against lopopolysaccharide (LPS)-induced acute lung injury(2016/03/22)
- Sphingosine-1-phosphate receptor-2 plays a protective role against anaphylactic shock through inhibiting eNOS.(2013)
- Essential role of class Iiα-isoform PI3 kinase C2α in sphingosine-1-phosphate (S1P)-induced endothelial cell migration.(2013/03/28)
- Class II PI3 kinase, PI3K-C2α, mediates S1P-induced endothelial cell migration through endosomal Rac1 activation.(conference：Gordon Research Conference on Vascular Cell Biology)(2013/02/01)
- Class II PI3K-C2α is essential for vascular barrier integrity.” JST-CREST International Symposium “Frontiers in Immunology and Inflammation: From Molecules and Inflammation(conference：JST-CREST International Symposium “Frontiers in Immunology and Inflammation: From Molecules and Inflammation.”)(2013/02/13)
- 蛍光イメージングが拓く見せる血管生物学(2013/09/26)
- Endothelial class II PI3K-C2α has an essential role in vascular formation and barrier function(conference：Gordon Research Conference on Vascular Cell Biology)(2013/02/01)
- クラスII型PI3キナーゼC2αは血管形成・血管恒常性維持に必須である(2012/12/14)
- Class II phosphatidylinositol 3-kinase α and β isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice(conference：The 98th Annual Meeting of The Physiological Society of Japan)(2021/03/29)
- イノシトールリン脂質特異的3’-ホスファターゼMTMR4はリソソーム機能・オートファジーを制御する(conference：第94 回日本生理学会大会)(2017/03/28)
Others
- Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system. Takuwa Y, Okamoto Y, Yoshioka K, Takuwa N. 1781 2008
- CALCIUM-DEPENDENT REGULATION OF RHO AND MYOSIN PHOSPHATASE IN VASCULAR SMOOTH MUSCLE Takuwa Y., Yoshioka K., Takuwa N., Wang Yu., Azam M.A., Sugimoto N. 16 2005
- Functions of Heteromeric Association Between Adenosine and P2Y Receptors. Nakata, H., Yoshioka, K., Kamiya, T., Tsuga, H., and Oyanagi, K. 26 2005
- ATP- and adenosine-Mediated Signaling in the Central Nervous System: Purinergic Receptor Complex: Generating Adenosine Nucleotide-Sensitive Adenosine Receptors. Yoshioka, K., Nakata, H. 94 2004
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「2型PI3キナーゼα酵素による細胞内小胞輸送調節を介した物質・情報交換制御の機構」(2011-2013)
○「心血管ホメオスターシスとその破綻における機能性脂質の役割」(2009-2011)
○「KO マウスを用いたクラスⅡ型PI3 キナーゼC2α の血管形成における役割」(2008-2010)
○「がん血行転移を制御するシグナリング機構」(2007-)
○「伸展力を介した血管平滑筋トーヌスのカルシウム感受性制御」(2004-)
○「膜動現象を制御するイノシトールリン脂質脱リン酸化酵素の肺発達・成熟における役割」(2017-2019)
○「血管内皮機能に必須なPI(3)P代謝酵素によるメンブレン・トラフィック制御」(2014-2016)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Basic Health Science(2018)
○Organ Physiology(2018)
○Basic Health Science(2017)
○Organ Physiology(2017)
○Basic Physiology(2016)
○Basic Health Science(2016)
○Basic Physiology(2015)
○Basic Physiology(2014)
○Basic Physiology(2013)
Classes (Graduate Schools)
○Human Body: Functions(2018)
○The Function of the Human Body(2018)
○The Function of the Human Body(2018)
○Signal Transduction in the Vascular System(2018)
○The Function of the Human Body(2017)
○Signal Transduction in the Vascular System(2017)
○Signal Transduction in the Vascular System(2017)
○The Function of the Human Body(2016)
○Signal Transduction in the Vascular System(2016)
○Signal Transduction in the Vascular System(2016)