last modified：2024/05/30
Vice President YACHIE Akihiro
Faculty, Affiliation
Administration Office
College and School Educational Field
Division of Medical Sciences, Graduate School of Medical Science
Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
Laboratory
Department of Pediatrics, Angiogenesis and Vascular Development TEL:076-265-2313 FAX:076-262-1866
Academic Background
【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor Graduate School, Division of Medicine 1983 Completed
【Academic background(Bachelor's Degree)】
Kanazawa University 1979
Career
Year & Month of Birth
1954/02
Academic Society
Pediatric Rheumatology Association of Japan
the Japan Pediatric Society
Award
the Japan Pediatric Society
the Japan Pediatric Society
Specialities
Pediatrics、Immunology、Pediatrics
Speciality Keywords
Clinical Immunology
Research Themes
T cell differentiation in Immune Abnormality Disorders
Molecular pathogenesis of primary immunodeficiency involved in T cell development is the major target of our research. Above all, followings are our current interest.
1) RAG1/RAG2 mutations and impaired T cell development.
2) Immunological reconstitution after stem cell transplantation.
3) Molecular and clinical impact of second site mutations in primary immunodeficiency diseases.
Oxidative Stress and Immune Response
Major goal of the research is to disclose the molecular pathogenic mechanism of various inflammatory/febrile illnesses. Moreover, we intend to establish novel approach to control inflammatory pathway of innate immunity.
1) HO-1 mediated regulation of inflammation.
2) Cytokine profiling and characterization of inflammatory illnesses.
3) Pathogenesis of autoinflammatory diseases and establishment of novel diagnostic strategies.
Pathogenic Mechanism of Abnormal Expansim of EBV-Infected Cells
EBV infection typically occurs as common infectious mononucleosis and in the case of normal immune capacity in the individual, remits and becomes a latent infection. In some cases, it transmits to lymphoid cells other than B cells, causing the infected cells to clonally expand, and by means such as excess production of cytokine, demonstrates various pathologies including hemophagocytic syndrome. I clarify the essence of these diseases and develop guidelines for early diagnosis and treatment.
(1) Analysis of various pathologies by EBV ectopic infention and investigation of the molecular mechanism of infected cell expansion.
(2) Investigation of molecular mechanism and clinical significance of CD5 expression reduction of infected CD8+T cells in EBV-HLH.
Books
Papers
- A simple and reliable method for screening retroviral producer clones without selectable markers. HUMAN GENE THERAPY 8 1189-1194 1997
- A syndrome of peripheral blood T-cell infection with Epstein-Barr virus (EBV) followed by EBV-positive T-cell lymphoma. BLOOD 91 6 2085-2091 1998
- Activated lansoprazole inhibits cancer cell adhesion to extracellular matrix components. Int. J. Oncol. 15 33-39 1999
- Administration of G-CSF to normal individuals diminishes L-selectin+ T cells in the peripheral blood that respond better to alloantigen stimulation than L-selectin- T cells. BONE MARROW TRANSPLANTATION 23 119-124 1999
- Age-dependent increase of IgE-binding and FceRI expression on circulating basophils in children. Pediatr. Res. 46 5 603-607 1999/05
- Antimicrobial activities of cefditoren against respiratory pathogens isolated from children in Japan. J. Infect. Chemother. 5 16-20 1999
- CD20 positive T-cell chronic lymphocytic leukemia. Br. J. Hematol. 102 1327-1329 1998
- CD27/CD70 interaction augments IgE secretion by promoting the differentiation of memory B cells into plasma cells. J. Immunol. 161 6496-6502 1998/04
- Characterization of immune function and analysis of RAG gene mutations in Omenn syndrome and related disorders. Clin. Exp. Immunol. 119 148-155 2000
- Characterization of T-cell repertoire of the bone marrow in immune-mediated aplastic anemia: evidence for the involvement of antigen-driven T cell response in cyclosporine-dependent aplastic anemia. BLOOD 93 9 3008-3016 1999
- Coexistence of lymphoblastic and monoblastic populations with identical mixed lineage leukemia gene rearrangements and shared immunoglobulin heavy chain rearrangements in leukemia developed in utero. 日本小児血液学会雑誌 22 1 372-377 2000/01
- Complete arrest from pro- to preB cells in a case of B cell-negative severe combined immunodeficiency (SCID) without recombinase activating gene (RAG) mutations. Clin. Exp. Immunol. 124 461-464 2001
- Cytoprotective role of heme oxygenase (HO)-1 in human kidney with various renal diseases. KIDNEY INTERNATIONAL 60 1858-1866 2001
- Decreased expression of 20-kD homologous restriction factor (HRF20, CD59) on T lymphocytes in Epstein-Barr virus (EBV)-induced infectious mononucleosis. Clin. Exp. Immunol. 108 260-265 1997
- Develomental changes and functional properties of human memory T cell subpopulations defined by CD60 expression. CELLULAR IMMUNOLOGY 187 117-123 1998
- Development of EBV-positive T-cell lymphoma following infection of peripheral blood T cells with EBV. Leukemia and Lymphoma 34 603-607 1999
- Development of improved adenosine deaminase retroviral vectors. J. Virol. 72 1769-1774 1997
- Differential cellular targets of Epstein-Barr virus (EBV) infection between acute EBV-associated hemophagocytic lymphohistiocytosis and chronic active EBV infection. BLOOD 98 1882-1888 2001
- Diffuse brain damage caused by acute twin-twin transfusion during late pregnancy. Acta Pediatrica Japonica (Pediatric International) 40 370-373 1998
- Diminished expression of CD59 on activated CD8+ T cells undergoing apoptosis in systemic lupus erythematosus and Sjogren syndrome. Scand. J. Immunol. 51 293-299 2000
- EBV-NK cell interactions and lymphoproliferative disorders. Leukemia and Lymphoma 29 491-498 1998
- Heme oxygenase-1 deficiency: the first autopsy case. HUMAN PATHOLOGY 33 1 125-130 2002
- Human pancreatic cancer cells disable function of Fas receptors at several levels in Fas signal transduction pathway. International Journal of Oncology 18 311-316 2001
- Human pancreatic cancer cells express non-functional Fas receptors and counterattack lymphocytes by expressing Fas ligand; a potential mechanism for immune escape. International Journal of Oncology 18 33-39 2001
- Hypokalemic periodic paralysis and mutations in the CACNL1A3 gene: Case study in a Japanese family. Pediatr. International 42 325-327 2000
- Increasing prevalence of ampicillin-resistant, non-beta-lactamase-producing strains of Haemophilus influenzae in children in Japan. CHEMOTHERAPY 45 15-21 1999
- Infectious mononucleosis as a disease of early childhood in Japan caused by primary Epstein-Barr virus infection. Acta Pediatrica Japonica (Pediatric International) 39 166-171 1997
- N-ethylmaleimide-enhanced phosphatidylserine externalization of human pancreatic cancer cells and immediate phosphatidyl-serine-mediated phagocytosis by macrophages. International Journal of Oncology 16 1111-1116 2000
- Novel Fas (CD95/APO-1) mutations in infants with a lymphoproliferative disorder. INTERNATIONAL IMMUNOLOGY 10 2 195-202 1997
- Osseous Langerhans' cell histiocytosis in a patient with Turner syndrome during grwoth hormone treatment. Clin. Pediatr. Endocrinol. 9 suppl. 14 77-78 2000
- Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J. Clin. Invest. 103 129-135 1999
- Structural evidence of exon-deletion mediated by Alu-Alu recombination in a human case with heme oxygenase-1 deficiency. HUMAN MUTATION Mutation in Brief #351 on line 2000
- Successful treatment of Epstein-Barr virus-associated natural killer cell large granular lymphocytic leukaemia using allogeneic peripheral blood stem cell transplantation. BONE MARROW TRANSPLANTATION 21 1279-1282 1998
- Tubular injury as a cardinal pathologic feature in human heme oxygenase-1 deficiency. Am. J. Kid. Dis. 35 5 863-870 2000
- An interesting tetrad of asplenia, inflammation, hemolysis, and nephritis Radhakrishnan, Nita; Yadav, Satya Prakash; Sachdeva, Anupam; Wada, Taizo; Yachie, Akihiro Pediatric Hematology and Oncology 28 8 723-726 2011/11/01
- Agranulocytosis after infectious mononucleosis Yokoyama, Tadafumi; Tokuhisa, Yuko; Toga, Akiko; Fujiki, Toshihiro; Sakakibara, Yasuhisa; Mase, Shintaro; Araki, Raita; Nishimura, Ryosei; Wada, Taizo; Fuseda, Tetsuya; Kato, Eiji; Yachie, Akihiro Journal of Clinical Virology 56 3 271-273 2013/03/01
- 38-year-old woman with recurrent abdominal pain, but no fever Iwata, Kentaro; Toma, Tomoko; Yachie, Akihiro International Journal of General Medicine 5 265-268 2012/12/01
- A case series of CAEBV of children and young adults treated with reduced-intensity conditioning and allogeneic bone marrow transplantation: A single-center study Watanabe, Yuko; Sasahara, Yoji; Satoh, Miki; Looi, Chung Yeng; Katayama, Saori; Suzuki, Tasuku; Suzuki, Nobu; Ouchi, Meri; Horino, Satoshi; Moriya, Kunihiko; Nanjyo, Yuka; Onuma, Masaei; Kitazawa, Hiroshi; Irie, Masahiro; Niizuma, Hidetaka; Uchiyama, Toru; Rikiishi, Takeshi; Kumaki, Satoru; Minegishi, Masayoshi; Wada, Taizo; Yachie, Akihiro; Tsuchiya, Shigeru; K?re, Shigeo European Journal of Haematology 91 3 242-248 2013/09/01
- Aberrant glycosylation of IgA in Wiskott-Aldrich syndrome and X-linked thrombocytopenia Shimizu, Masaki; Kanegane, Hirokazu; Wada, Taizo; Motoyoshi, Yaeko; Morio, Tomohiro; Candotti, Fabio; Yachie, Akihiro Journal of Allergy and Clinical Immunology 131 2 587-590000 2013/02/01
- Cytokine profiles in children with primary Epstein-Barr virus infection Wada, Taizo; Muraoka, Masahiro; Yokoyama, Tadafumi; Toma, Tomoko; Kanegane, Hirokazu; Yachie, Akihiro Pediatric Blood and Cancer 60 7 E46-E48 2013/07/01
- Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-κB and MAPK pathways Miwa, Shinji; Sugimoto, Naotoshi; Yamamoto, Norio; Shirai, Toshiharu; Nishida, Hideji; Hayashi, Katsuhiro; Kimura, Hiroaki; Takeuchi, Akihiko; Igarashi, Kentaro; Yachie, Akihiro; Tsuchiya, Hiroyuki Anticancer Research 32 9 3643-3649 2012/09/01
- Carbon monoxide (CO)-releasing molecule-derived CO regulates tissue factor and plasminogen activator inhibitor type 1 in human endothelial cells Maruyama, Keiko; Morishita, Eriko; Yuno, Takeo; Sekiya, Akiko; Asakura, Hidesaku; Ohtake, Shigeki; Yachie, Akihiro Thrombosis Research 130 3 e188-e193 2012/09/01
- Cellular Heat acclimation regulates cell growth, cell morphology, mitogen-activated protein kinase activation, and expression of aquaporins in mouse fibroblast cells Sugimoto, Naotoshi; Shido, Osamu; Matsuzaki, Kentaro; Ohno-Shosaku, Takako; Hitomi, Yoshiaki; Tanaka, Masao; Sawaki, Toshioki; Fujita, Yoshimasa; Kawanami, Takanori; Masaki, Yasushi; Okazaki, Toshiro; Nakamura, Hiroyuki; Koizumi, Shoichi; Yachie, Akihiro; Umehara, Hisanori Cellular Physiology and Biochemistry 30 2 450-457 2012/07/01
- Clinical and immunophenotypic features of atypical complete DiGeorge syndrome Vu, Quangvan; Wada, Taizo; Toma, Tomoko; Tajima, Hanako; Maeda, Miho; Tanaka, Risa; Oh-Ishi, Tsutomu; Yachie, Akihiro Pediatrics International 55 1 2-6 2013/02/01
- Compensated inflammation in systemic juvenile idiopathic arthritis: Role of alternatively activated macrophages Shimizu, Masaki; Yachie, Akihiro Cytokine 60 1 226-232 2012/10/01
- Caffeine activates tumor suppressor PTEN in sarcoma cells Miwa, Shinji; Sugimoto, Naotoshi; Shirai, Toshiharu; Hayashi, Katsuhiro; Nishida, Hideji; Ohnari, Issei; Takeuchi, Akihiko; Yachie, Akihiro; Tsuchiya, Hiroyuki International Journal of Oncology 39 2 465-472 2011/08/01
- An infant with PELVIS (perineal hemangioma, external genital malformations, lipomyelomeningocele, vesicorenal abnormalities, imperforate anus, and skin tag) syndrome misdiagnosed as diaper rash Shimizu, Masaki; Sakai, Seisho; Tatekawa, Yukihiro; Ishikawa, Sayaka; Miyamoto, Masatoshi; Yachie, Akihiro Journal of Pediatrics 165 3 2014/01/01
- An infant with recurrent convulsive seizures of 3 weeks' duration: Answers Shimizu, Masaki; Niida, Yo; Koizumi, Shoichi; Yachie, Akihiro Pediatric Nephrology 1-3 2013/09/13
- A case of acute encephalopathy with hemophagocytic lymphohistiocytosis and clonal T-cell expansion Wada, Taizo; Nishiura, Kashiku; Kuroda, Mondo; Asai, Erika; Vu, Quangvan; Toma, Tomoko; Niida, Yo; Yachie, Akihiro Brain and Development 34 5 376-379 2012/05/01
- Anomalous origin with myocardial bridging in coronary artery: Stealth images in computed tomography Yamamoto, Ryusuke; Kawashiri, Masaaki; Tada, Hayato; Tsubokawa, Toshinari; Uchiyama, Katsuharu; Konno, Tetsuo; Hayashi, Kenshi; Saito, Takekatsu; Ohta, Kunio; Yachie, Akihiro; Yamagishi, Masakazu Journal of the American College of Cardiology 60 23 2012/12/11
- Alu-mediated large deletion of the CDSN gene as a cause of peeling skin disease Wada, Taizo; Matsuda, Yusuke; Muraoka, Masahiro; Toma, Tomoko; Takehara, Kazuhiko; Fujimoto, Manabu; Yachie, Akihiro Clinical Genetics 86 4 383-386 2014/01/01
- Are regimens containing rituximab effective in the initial treatment of Epstein-Barr virus-positive natural killer cell lymphoproliferative disease-associated hemophagocytic lymphohistiocytosis? Imashuku, Shinsaku; Kudo, Naoko; Kubo, Kagekatsu; Yachie, Akihiro International Journal of Hematology 98 3 375-377 2013/09/01
- Familial mediterranean fever: Genotype-phenotype correlations in japanese patients Migita, Kiyoshi; Agematsu, Kazunaga; Yazaki, Masahide; Nonaka, Fumiaki; Nakamura, Akinori; Toma, Tomoko; Kishida, Dai; Uehara, Ritei; Nakamura, Yoshikazu; Jiuchi, Yuka; Masumoto, Junya; Furukawa, Hiroshi; Ida, Hiroaki; Terai, Chihiro; Nakashima, Yoshikazu; Kawakami, Atsushi; Nakamura, Tadashi; Eguchi, Katsumi; Yasunami, Michio; Yachie, Akihiro Medicine (United States) 93 3 158-164 2014/01/01
- Regulatory Role of Host IL-17 Via Control of Host Macrophage Activation Contributes to Less Acute Gvhd Kuroda, Rie;Sato, Katsuaki;Maeba, Hideaki;Fujiki, Toshihiro;Mase, Shintaro;Araki, Raita;Naka, Kazuhito;Naito, Makoto;Iwakura, Yoichiro;Yachie, Akihiro;Koizumi, Shoichi;Nishimura, Ryosei BLOOD 120 21 0-0 2012
- Caffeine Induces Apoptosis of Osteosarcoma Cells by Inhibiting AKT/mTOR/S6K, NF-kappa B and MAPK Pathways Miwa, Shinji;Sugimoto, Naotoshi;Yamamoto, Norio;Shirai, Toshiharu;Nishida, Hideji;Hayashi, Katsuhiro;Kimura, Hiroaki;Takeuchi, Akihiko;Igarashi, Kentaro;Yachie, Akihiro;Tsuchiya, Hiroyuki ANTICANCER RESEARCH 32 9 3643-3649 2012
- Only High Concentration of Immunoglobulin Inhibits Activation of Lymphocytes: Potential Use of Immunoglobulin for Preventing Gvhd Maeba, Hideaki;Kuroda, Rie;Hujiki, Toshihiro;Mase, Shintaro;Araki, Raita;Koizumi, Shoichi;Yachie, Akihiro;Nishimura, Ryosei BLOOD 120 21 0-0 2012
- Allogeneic Cytokine-Induced Killer Cell-Dependent Eimination of Host Dendritic Cells Leads to Less Graft-Versus-Host Disease Mase, Shintaro;Maeba, Hideaki;Fujiki, Toshihiro;Kuroda, Rie;Araki, Raita;Koizumi, Shoichi;Yachie, Akihiro;Nishimura, Ryosei BLOOD 120 21 0-0 2012
- Serum IL-18 as a potential specific marker for differentiating systemic juvenile idiopathic arthritis from incomplete Kawasaki disease Takahara, Tadamori;Shimizu, Masaki;Nakagishi, Yasuo;Kinjo, Noriko;Yachie, Akihiro RHEUMATOLOGY INTERNATIONAL 35 1 81-84 2015/01/01
- Cutaneous Calcinosis in Juvenile Dermatomyositis Shimizu, Masaki;Ueno, Kazuyuki;Ishikawa, Sayaka;Yokoyama, Tadafumi;Kasahara, Yoshihito;Yachie, Akihiro JOURNAL OF PEDIATRICS 163 3 921-921 2013
- Upregulation of aquaporin expression in the salivary glands of heat-acclimated rats Sugimoto, Naotoshi;Matsuzaki, Kentaro;Ishibashi, Hiroaki;Tanaka, Masao;Sawaki, Toshioki;Fujita, Yoshimasa;Kawanami, Takafumi;Masaki, Yasufumi;Okazaki, Toshiro;Sekine, Joji;Koizumi, Shoichi;Yachie, Akihiro;Umehara, Hisanori;Shido, Osamu SCIENTIFIC REPORTS 3 0 0-0 2013
- Normal Values for Pediatric Urinary Biochemistry Ohta, Kazuhide;Fujiki, Takuma;Yamamiya, Mari;Inoue, Natsumi;Senda, Yumi;Sakazume, Shinobu;Ueno, Kazuyuki;Yokoyama, Tadafumi;Shimizu, Masaki;Yachie, Akihiro PEDIATRIC NEPHROLOGY 28 8 1476-1477 2013
- Successful bone marrow transplantation with reduced intensity conditioning in a patient with delayed-onset adenosine deaminase deficiency Kanegane, Hirokazu; Taneichi, Hiromichi; Nomura, Keiko; Wada, Taizo; Yachie, Akihiro; Imai, Kohsuke; Ariga, Tadashi; Santisteban, Ines; Hershfield, Michael S J E; Miyawaki, Toshio Pediatric Transplantation 17 1 E29-E32 2013/02/01
- Serum IL-18 as a potential specific marker for differentiating systemic juvenile idiopathic arthritis from incomplete Kawasaki disease Takahara, Tadamori; Shimizu, Masaki; Nakagishi, Yasuo; Kinjo, Noriko; Yachie, Akihiro Rheumatology International 2014/06/12
- Role of activated macrophage and inflammatory cytokines in the development of calcinosis in juvenile dermatomyositis Shimizu, Masaki; Ueno, Kazuyuki; Ishikawa, Sayaka; Kasahara, Yoshihito; Yachie, Akihiro Rheumatology (United Kingdom) 53 4 766-767 2014/04/01
- Phenotypic analysis in a case of hydroa vacciniforme-like eruptions associated with chronic active Epstein-Barr virus disease of γλ T cells Tanaka, Chihiro; Hasegawa, Minoru; Fujimoto, Manabu; Iwats?ki, Keiji; Yamamoto, Takenobu; Yamada, Kayo; Kawa, Keisei; Saikawa, Yutaka; Toga, Akiko; Mase, Shintaro; Wada, Taizo; Takehara, Kazuhiko; Yachie, Akihiro British Journal of Dermatology 166 1 216-218 2012/01/01
- Natural history of medium-sized atrial septal defect in pediatric cases Saito, Takekatsu; Ohta, Kunio; Nakayama, Yuko; Hashida, Yoko; Maeda, Akiko; Maruhashi, Keiko; Yachie, Akihiro Journal of Cardiology 60 3 248-251 2012/09/01
- Early diagnosis of Danon disease: Flow cytometric detection of lysosome-associated membrane protein-2-negative leukocytes Hashida, Yoko; Wada, Taizo; Saito, Takekatsu; Ohta, Kunio; Kasahara, Yoshihito; Yachie, Akihiro Journal of Cardiology 2014/06/10
- Diffusion-weighted MRI of exercise-induced acute renal failure (ALPE) Ohta, Kazuhide; Yokoyama, Tadafumi; Shimizu, Masaki; Mizuno, Kazunori; Sakazume, Shinobu; Fujiki, Takuma; Saikawa, Yutaka; Yachie, Akihiro Pediatric Nephrology 26 8 1321-1324 2011/08/01
- Down-regulation of CD5 expression on activated CD8+ T cells in familial hemophagocytic lymphohistiocytosis with perforin gene mutations Wada, Taizo; Sakakibara, Yasuhisa; Nishimura, Ryosei; Toma, Tomoko; Ueno, Yasuhisa; Horita, Seiki; Tanaka, Taihei; Nishi, Masanori; Kato, Keisuke; Yasumi, Takahiro; Ohara, Osamu; Yachie, Akihiro Human Immunology 74 12 1579-1585 2013/10/11
- Increased expression of epidermal thymic stromal lymphopoietin in inflammatory peeling skin syndrome Wada, Taizo; Toma, Tomoko; Hamaguchi, Yasuhito; Yachie, Akihiro Journal of Dermatology 41 5 448-449 2014/01/01
- Lactobacillus casei cell wall extract directly stimulates the expression of COX2 independent of Toll-like receptor 2 in rat glial cells Sugimoto, Naotoshi; Ohta, Kunio; Saito, Takekatsu; Nakayama, Yuko; Nakamura, Taichi; Maeda, Akiko; Yachie, Akihiro Journal of Microbiology, Immunology and Infection 46 5 389-392 2013/10/01
- Isolated congenital megacystis without intestinal obstruction: A mild variant of chronic intestinal pseudoobstruction syndrome? Shimizu, Masaki; Nishio, Sayaka; Ueno, Kazuyuki; Yokoyama, Tadafumi; Sakai, Seisho; Nagaoki, Shuya; Sugimoto, Naotoshi; Ohta, Kazuhide; Miyamoto, Masatoshi; Yachie, Akihiro Journal of Pediatric Surgery 46 11 E29-E32 2011/11/01
- Rapid detection of intracellular p47phox and p67phox by flow cytometry; Useful screening tests for chronic granulomatous disease Wada, Taizo; Muraoka, Masahiro; Toma, Tomoko; Imai, Tsuyoshi; Shigemura, Tomonari; Agematsu, Kazunaga; Haraguchi, Kohei; Moriuchi, Hiroyuki; Oh-Ishi, Tsutomu; Kitoh, Toshiyuki; Ohara, Osamu; Morio, Tomohiro; Yachie, Akihiro Journal of Clinical Immunology 33 4 857-864 2013/05/01
- Activation of tumor suppressor protein PTEN and induction of apoptosis are involved in cAMP-mediated inhibition of cell number in B92 glial cells Sugimoto, Naotoshi;Miwa, Shinji;Ohno-Shosaku, Takako;Tsuchiya, Hiroyuki;Hitomi, Yoshiaki;Nakamura, Hiroyuki;Tomita, Katsuro;Yachie, Akihiro;Koizumi, Shoichi NEUROSCIENCE LETTERS 497 1 55-59 2011
- Superior Immunomodulatory Effects of Cultured Mast Cells: Potent Strategy for Treatment of Gvhd Araki, Raita;Maeba, Hideaki;Kuroda, Rie;Fujiki, Toshihiro;Mase, Shintaro;Koizumi, Shoichi;Yachie, Akihiro;Nishimura, Ryosei BLOOD 120 21 0-0 2012
- Treatment of refractory polyarticular juvenile idiopathic arthritis with tacrolimus Shimizu, Masaki; Ueno, Kazuyuki; Ishikawa, Sayaka; Tokuhisa, Yuko; Inoue, Natsumi; Yachie, Akihiro Rheumatology (United Kingdom) 53 11 2120-2122 2014/01/01
- Successful treatment of primary sclerosing cholangitis with a steroid and a probiotic Shimizu, Masaki; Iwasaki, Hidenori; Mase, Shintaro; Yachie, Akihiro Case Reports in Gastroenterology 6 2 249-253 2012/05/01
- Successful multitarget therapy using mizoribine and tacrolimus for refractory Takayasu arteritis Shimizu, Masaki; Ueno, Kazuyuki; Ishikawa, Sayaka; Tokuhisa, Yuko; Inoue, Natsumi; Yachie, Akihiro Rheumatology (United Kingdom) 53 8 1530-1532 2014/01/01
- Multiple reversions of an IL2RG mutation restore T cell function in an X-linked severe combined immunodeficiency patient Kawai, Tomoki; Saito, Megumu; Nishikomori, Ryuta; Yasumi, Takahiro; Izawa, Kazushi; Murakami, Tomohiko; Okamoto, Shigefumi; Mori, Yasuko; Nakagawa, Noriko; Imai, Kohsuke; Nonoyama, Shigeaki; Wada, Taizo; Yachie, Akihiro; Ohmori, Katsuyuki; Nakahata, Tatsutoshi; Heike, Toshio Journal of Clinical Immunology 32 4 690-697 2012/08/01
- Evaluation of T-cell receptor diversity in pediatric patients with minimal change nephrotic syndrome Ohta, Kazuhide; Shimizu, Masaki; Yokoyama, Tadafumi; Nishio, Sayaka; Ueno, Kazuyuki; Seno, Akiko; Yachie, Akihiro Clinical Nephrology 77 4 296-304 2012/04/01
- Honeycomb Appearance of the Liver in Wilson's Disease Tokuhisa, Yuko; Shimizu, Masaki; Yachie, Akihiro Clinical Gastroenterology and Hepatology 10 3 2012/03/01
- Distinct subsets of patients with systemic juvenile idiopathic arthritis based on their cytokine profiles Shimizu, Masaki; Nakagishi, Yasuo; Yachie, Akihiro Cytokine 61 2 345-348 2013/02/01
- Development of IgA nephropathy-like glomerulonephritis associated with Wiskott-Aldrich syndrome protein deficiency Shimizu, Masaki; Nikolov, Nikolay P.; Ueno, Kazuyuki; Ohta, Kunio; Siegel, Richard M.; Yachie, Akihiro; Candotti, Fabio Clinical Immunology 142 2 160-166 2012/02/01
- Delayed onset adenosine deaminase deficiency associated with acute disseminated encephalomyelitis Nakaoka, Hideyuki; Kanegane, Hirokazu; Taneichi, Hiromichi; Miya, Kazushi; Yang, Xi; Nomura, Keiko; Takezaki, Shunichiro; Yamada, Masafumi; Ohara, Osamu; Kamae, Chikako; Imai, Kohsuke; Nonoyama, Shigeaki; Wada, Taizo; Yachie, Akihiro; Hershfield, Michael S J E; Ariga, Tadashi; Miyawaki, Toshio International Journal of Hematology 95 6 692-696 2012/06/01
- Urinary Heme Oxygenase-1 as a Sensitive Indicator of Tubulointerstitial Inflammatory Damage in Various Renal Diseases Yokoyama, Tadafumi;Shimizu, Masaki;Ohta, Kazuhide;Yuno, Tomoji;Okajima, Michiko;Wada, Taizo;Toma, Tomoko;Koizumi, Shoichi;Yachie, Akihiro AMERICAN JOURNAL OF NEPHROLOGY 33 5 414-420 2011
- Analysis of mutations and recombination activity in RAG-deficient patients Asai, Erika;Wada, Taizo;Sakakibara, Yasuhisa;Toga, Akiko;Toma, Tomoko;Shimizu, Takashi;Nampoothiri, Sheela;Imai, Kohsuke;Nonoyama, Shigeaki;Morio, Tomohiro;Muramatsu, Hideki;Kamachi, Yoshiro;Ohara, Osamu;Yachie, Akihiro CLINICAL IMMUNOLOGY 138 2 172-177 2011
- A Genetic Variation in the Heme Oxygenase-1 Gene Predicts the Outcome of HLA-Fully-Matched Unrelated Bone Marrow Transplantation Morishita, Eriko;Maruyama, Keiko;Takami, Akiyoshi;Onizuka, Makoto;Kawase, Takakazu;Morishima, Yasuo;Fukuda, Takahiro;Kodera, Yoshihisa;Ohtake, Shigeki;Yachie, Akihiro;Nakao, Shinji BLOOD 118 21 862-862 2011
- Cannabinoids prevent TLR2-induced inflammation via CB1 receptor in human glioblastoma cells Echigo, Ryousuke;Sugimoto, Naotoshi;Yachie, Akihiro;Ohno-Shosaku, Takako NEUROSCIENCE RESEARCH 71 0 E197-E197 2011
- Attempting to Classify Prolonged Graft-Versus-Host-Disease According to Monocyte Activation Status in Addition to T-Cell Kuroda, Rie;Maeba, Hideaki;Mase, Shintaro;Araki, Raita;Fujiki, Toshihiro;Koizumi, Shoichi;Yachie, Akihiro;Nishimura, Ryosei BLOOD 118 21 1313-1313 2011
- Both Tissue-Derived and Bone Marrow-Derived Host IL-17 Producing Cells Are Required for Preventing Acute Graft-Versus-Host Disease Kuroda, Rie;Maeba, Hideaki;Sato, Katsuaki;Naka, Kazuhito;Mase, Shintaro;Araki, Raita;Fujiki, Toshihiro;Iwakura, Yoichiro;Yachie, Akihiro;Koizumi, Shoichi;Nishimura, Ryosei BLOOD 118 21 1281-1281 2011
- Evaluating Prolonged Gvhd Based On Monocyte and T-Cell Activation, Leads to Early Detection of Immunological Changes Before Gvhd Exacerbations Kuroda, Rie;Fujiki, Toshihiro;Mase, Shintaro;Araki, Raita;Maeba, Hideaki;Koizumi, Shoichi;Yachie, Akihiro;Nishimura, Ryosei BLOOD 120 21 0-0 2012
- Attempting to Redefine Renal Involvement by Utilizing 3D Reconstruction Models of CT Imagings in Pediatric Acute Leukemia Fujiki, Toshihiro;Araki, Raita;Mase, Shintaro;Kuroda, Rie;Maeba, Hideaki;Yachie, Akihiro;Nishimura, Ryosei BLOOD 120 21 0-0 2012
- Are regimens containing rituximab effective in the initial treatment of Epstein-Barr virus-positive natural killer cell lymphoproliferative disease-associated hemophagocytic lymphohistiocytosis? Imashuku, Shinsaku;Kudo, Naoko;Kubo, Kagekatsu;Yachie, Akihiro INTERNATIONAL JOURNAL OF HEMATOLOGY 98 3 375-377 2013
- Wild-type macrophages reverse disease in heme oxygenase 1-deficient mice Kovtunovych, Gennadiy; Ghosh, Manik Chandra; Ollivierre, Wade; Weitzel, R. Patrick; Eckhaus, Michael A.; Tisdale, John F.; Yachie, Akihiro; Rouault, Tracey A. Blood 124 9 1522-1530 2014/08/28
- Urinary neopterin: an immune activation marker in mesangial proliferative glomerulonephritis Ueno, Kazuyuki; Shimizu, Masaki; Yokoyama, Tadafumi; Ishikawa, Sayaka; Tasaki, Yuko; Inoue, Natsumi; Sugimoto, Naotoshi; Ohta, Kazuhide; Yachie, Akihiro Clinical and Experimental Nephrology 2014/05/25
- Transient impairment of NK cell function in an infant born to a mother with adult-onset Still's disease: Perinatal effect of maternal IL-18 Shimizu, Masaki; Sakakibara, Yasuhisa; Kawano, Mitsuhiro; Yachie, Akihiro Clinical Immunology 143 3 273-274 2012/06/01
- Transducible form of p47 phox and p67 phox compensate for defective NADPH oxidase activity in neutrophils of patients with chronic granulomatous disease Honda, Fumiko; Hane, Yumiko; Toma, Tomoko; Yachie, Akihiro; Kim, Eunsung; Lee, Sangkyou; Takagi, Masatoshi; Mizutani, Shuki; Morio, Tomohiro Biochemical and Biophysical Research Communications 417 1 162-168 2012/01/06
- Thomsen-Friedenreich antigen exposure as a cause of Streptococcus pyogenes-associated hemolytic-uremic syndrome Shimizu, Masaki; Yokoyama, Tadafumi; Sakashita, Natsuma; Sato, Akira; Ueno, Kazuyuki; Akita, Chisato; Ohta, Kazuhide; Kitano, Etsuko; Hatanaka, Michiyo; Kitamura, Hajime; Saikawa, Yutaka; Yachie, Akihiro Clinical Nephrology 78 4 328-331 2012/10/01
- Theobromine, the primary methylxanthine found in theobroma cacao, prevents malignant glioblastoma proliferation by negatively regulating phosphodiesterase-4, extracellular signal-regulated kinase, Akt/mammalian target of rapamycin kinase, and nuclear factor-kappa B Sugimoto, Naotoshi; Miwa, Shinji; Hitomi, Yoshiaki; Nakamura, Hiroyuki; Tsuchiya, Hiroyuki; Yachie, Akihiro Nutrition and Cancer 66 3 419-423 2014/04/03
- The first report of adolescent TAFRO syndrome, a unique clinicopathologic variant of multicentric Castleman's disease Kubokawa, Ikuko; Yachie, Akihiro; Hayakawa, Akira; Hirase, Satoshi; Yamamoto, Nobuyuki; Mori, Takeshi; Yanai, Tomoko; Takeshima, Yasuhiro; Kyo, Eiryu; Kageyama, Goichi; Nagai, Hiroshi; Uehara, Keiichiro; Kojima, Masaru; Iijima, Kazumoto BMC Pediatrics 14 1 2014/06/02
- Multiple osteonecrosis in a patient with juvenile systemic lupus erythematosus Shimizu, Masaki; Tokuhisa, Yuko; Ishikawa, Sayaka; Ueno, Kazuyuki; Yokoyama, Tadafumi; Yachie, Akihiro Journal of Clinical Rheumatology 19 3 2013/04/01
- Molecular and immunohistochemical detection of rotavirus in urinary sediment cells of children with rotavirus gastroenteritis Yokoyama, Tadafumi; Sugimoto, Naotoshi; Taniguchi, Koki; Komoto, Satoshi; Yuno, Tomoji; Ohta, Kunio; Hashimoto, H.; Seno, Akiko; Ashida, Akira; Fujieda, Mikiya; Nishio, Sayaka; Ueno, Kazuyuki; Shimizu, Masaki; Yachie, Akihiro Clinical Microbiology and Infection 17 8 1190-1193 2011/08/01
- Massive hyper-reactive hematopoietic nests in bilateral iliac bones in a patient with mild aplastic anemia Nishimura, Ryosei; Mase, Shintaro; Araki, Raita; Fujiki, Toshihiro; Kuroda, Rie; Maeba, Hideaki; Koizumi, Shoichi; Yachie, Akihiro Pediatric Blood and Cancer 61 10 1903-1904 2014/01/01
- Sustained elevation of serum interleukin-18 and its association with hemophagocytic lymphohistiocytosis in XIAP deficiency Wada, Taizo; Kanegane, Hirokazu; Ohta, Kazuhide; Katoh, Fumiyo; Imamura, Toshihiko; Nakazawa, Yozo; Miyashita, Ritsuko; Hara, Junichi; Hamamoto, Kazuko; Yang, Xi; Filipovich, Alexandra Hult; Marsh, Rebecca A.; Yachie, Akihiro Cytokine 65 1 74-78 2014/01/01
- Long-term Heat Exposure Prevents Hypoxia-Induced Apoptosis in Mouse Fibroblast Cells Sugimoto, Naotoshi; Shido, Osamu; Matsuzaki, Kentaro; Katakura, Masanori; Hitomi, Yoshiaki; Tanaka, Masao; Sawaki, Toshioki; Fujita, Yoshimasa; Kawanami, Takafumi; Masaki, Yasufumi; Okazaki, Toshiro; Nakamura, Hiroyuki; Koizumi, Shoichi; Yachie, Akihiro; Umehara, Hisanori Cell Biochemistry and Biophysics 70 1 301-307 2014/01/01
- Expansion of a liver-infiltrating cytotoxic T-lymphocyte clone in concert with the development of hepatitis-associated aplastic anaemia Ikawa, Yasuhiro; Nishimura, Ryosei; Kuroda, Rie; Mase, Shintaro; Araki, Raita; Maeba, Hideaki; Wada, Taizo; Toma, Tomoko; Koizumi, Shoichi; Yachie, Akihiro British Journal of Haematology 161 4 599-602 2013/05/01
- Only Dendritic Cells, but Not Lymphocytes, Acquired Tolerogenicity by PUVA-Treatment by Upregulation of Indoleamine 2,3-Dioxygenase (IDO) Maeba, Hideaki;Kuroda, Rie;Niida, Yo;Mase, Shintaro;Araki, Raita;Fujiki, Toshihiro;Yachie, Akihiro;Koizumi, Shoichi;Nishimura, Ryosei BLOOD 118 21 951-951 2011
- Human Heme Oxygenase-1 Deficiency Presenting With Hemolysis, Nephritis, and Asplenia Radhakrishnan, Nita;Yadav, Satya Prakash;Sachdeva, Anupam;Pruthi, Praveen K.;Sawhney, Sujata;Piplani, Tarun;Wada, Taizo;Yachie, Akihiro JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY 33 1 74-78 2011
- Cannabinoids prevent TLR2-induced inflammation in human glioma cells Echigo, Ryosuke;Sugimoto, Naotoshi;Yachie, Akihiro;Ohono-Shosaku, Takako FASEB JOURNAL 25 0 0-0 2011
- Delayed Wound Healing in Leukocyte Adhesion Deficiency Type 1 Wada, Taizo;Tone, Yumi;Shibata, Fumie;Toma, Tomoko;Yachie, Akihiro JOURNAL OF PEDIATRICS 158 2 342-342 2011
- Aplastic anemia successfully treated with rituximab: the possible role of aplastic anemia-associated autoantibodies as a marker for response Takamatsu, Hiroyuki;Yagasaki, Hiroshi;Takahashi, Yoshiyuki;Hama, Asahito;Saikawa, Yutaka;Yachie, Akihiro;Koizumi, Shoichi;Kojima, Seiji;Nakao, Shinji EUROPEAN JOURNAL OF HAEMATOLOGY 86 6 541-545 2011
Conference Presentations
Others
- Role of heme oxygenase-1 in cardiovascular diseases: A novel target for molecular intervention? 8 444-446 2001
- Role of heme oxygenase-1 in cardiovascular diseases: a novel target for molecular intervention. Ohta K 8 5 444-446 2001
- Oligoclonal expansion of circulating and tissue-infiltrating CD8+ T cells with killer/effector phenotypes in juvenile dermatomyositis syndrome. Mizuno K, Nagaoki S et al 137 1 187-194 2004//7
- Heme oxygenase-1 production by peripheral blood monocytes during acute inflammatory illnesses of children. 228 5 550-556 2003//5
- Epstein-Barr virus-associated T/natural killer cell lymphoproliferative diseases. Kanegane H, Kasahara Y 40 2 124-132 2003//4
- Detection of T lymphocytes with a seconde-site mutation in skin lesions of atypical X-linked severe combined immunodeficiency mimicking Omenn syndrome. Wada T, Yasui M, et al 112 5 1872-1875 2008//9
- Skin infiltration of CD56bright CD16- natural killer cells in a case of X-SCID with Omenn syndrome-like manifestations. Shibata F, Toma T et al 79 1 81-85 2007//7
- Immunophenotypic analysis of Epstein-Barr virus (EBV)-infected CD8+ T cells in a patient with EBV-associated hemophagocytic lymphohistiocytosis. Wada T, Kurokawa T, Toma T et al 79 1 81-85 2007//7
- Clonotypic analysis of T cell reconstitution after haematopoietic stem cell transplantation (HSCT) in patients with severe combined immunodeficiency. Okamoto H, Arii C, Shibata F et al 148 3 450-460 2007/06
- Selective expantion of CD16high CCR2- subpopulation of circulating monocytes with preferential production of haem oxygenase (HO)-1 in response to acute inflammation. Mizuno K, Toma T et al 142 3 461-470 2005/12
- Oligoclonal expansion of T lymphocytes with multiple second-site mutations leads to Omenn syndrome in a patient with RAG1-deficient severe combined immunodeficiency. Wada T, Toma T et al 106 6 2099-2101 2005//9
- Expansion of activated eosinophils in infants with severe atopic dermatitis. Toma T, Mizuno K et al 47 1 32-38 2005//2
Arts and Fieldwork
Patent
Theme to the desired joint research
○Control of inflammation and cytokine regulation
Grant-in-Aid for Scientific Research
○「新生児・乳児期におけるアレルギー感作機序に関する研究」(1997-)
○「新生児・乳児期におけるアレルギー感作機序に関する研究」(1998-)
○「ヘムオキシゲナーゼ１（HO-1）の多面的生理学的意義：HO-1欠損症からの学習」(2001-)
○「ヘムオキシゲナーゼ１による炎症制御機構の解析と新しい炎症治療戦略に関する研究」(2002-)
○「ヘムオキシゲナーゼ１産生制御による単球機能の調節と炎症治療戦略の開」(2004-)
○「生体侵襲時におけるヘムオキシゲナーゼ1を介する血栓形成制御機構の解明」(2004-)
○「複合免疫不全症の多様な臨床像とその背景となる分子生物学的基盤に関する研究」(2007-)
○「ヘムオキシゲナーゼ‐１（ＨＯ‐１）が凝固・線溶系因子の発現調節に果たす役割の解明」(2007-)
○「早期治療介入のための新しいEBV関連リンパ増殖性疾患診断指標の確立」(2009-2011)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Normal Growth & Development/Pediatrics(2017)
○Clinical Genetics(2017)
○Pediatrics(BSL)(2017)
○Pediatric Physical Diagnosis(CE)(2017)
○Congenital Anomalies(2017)
○Congenital Anomalies(2016)
○Pediatric Physical Diagnosis(CE)(2016)
○Normal Growth & Development/Pediatrics(2016)
○Pediatrics(BSL)(2016)
○Clinical Genetics(2016)
Classes (Graduate Schools)
○Pathophysiology of Vasoangiogenesis(2017)
○Neonatal and Developmental Medicine(2017)
○Neonatal and Developmental Medicine(2017)
○Environment and Health -Introductory(2017)
○Neonatal and Developmental Medicine(2016)
○Pathophysiology of Vasoangiogenesis(2016)
○Environment and Health -Introductory(2016)
○Neonatal and Developmental Medicine(2016)
International Project
International Students
Lecture themes
○Cytokines in autoinflammatory disease