last modified：2025/04/08
Professor MATSUSHITA, Takashi
Faculty, Affiliation
Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences
College and School Educational Field
Division of Medical Sciences, Graduate School of Medical Science
Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
Laboratory
TEL:076-265-2342 FAX:076-234-4270
Academic Background
【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor Graduate School, Division of Medicine 200603 Completed
【Academic background(Bachelor's Degree)】
Kanazawa University 199903
Career
Duke University, Department of Immunology(2007/04/01-)
金沢大学大学院医学系研究科(2010/04/01-)
Year & Month of Birth
1974/06
Academic Society
Award
Specialities
Dermatology
Speciality Keywords
Dermatology,Systemic sclerosis,Dermatomyositis,Regulatory B cell,Autoantibody
Research Themes
Systemic sclerosis
Regulatory B cell
Cytokine
Books
- Identifying Regulatory B Cells (B10 cells) That Produce IL-10 In Mice. 677 99-111 2011/02
Papers
- A novel splenic B1 regulatory cell subset suppresses an allergic disease via PI3K-Akt pathway activation. Matsushita T, et al J Allergy Clin Immunol. 138 4 1170-1182 2016/04
- Characterization of a Rare IL-10-Competent B Cell Subset in Man That Parallels Mouse Regulatory B10 Cells. Iwata Y*, Matsushita T*, Horikawa, DiLillo, Yanaba, Venturi, Szabolcs, Bernstein, Magro, Williams, Hall, St.Clair, and Tedder TF (*equal contribution) BLOOD 117 530-41 2011/01
- Regulatory B Cells (B10 Cells) and Regulatory T Cells Have Independent Roles in Controlling Experimental Autoimmune Encephalomyelitis Initiation and Late-Phase Immunopathogenesis. Matsushita T, Horikawa M, Iwata Y, Tedder TF JOURNAL OF IMMUNOLOGY 185 2240-2252 2010/05
- Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. Matsushita T, Yanaba K, Bouaziz JD, Fujimoto M, Tedder TF JOURNAL OF CLINICAL INVESTIGATION 118 3420-30 2008/10
- BAFF Antagonist Attenuates the Development of Skin Fibrosis in Tight-Skin Mice. Matsushita T, Fujimoto M, Hasegawa M, Matsushita Y, Komura K, Ogawa F, Watanabe R, Takehara K, Sato S. JOURNAL OF INVESTIGATIVE DERMATOLOGY 127 2772-80 2007/10
- Elevated Serum BAFF Levels in Patients with Systemic Sclerosis (SSc): Enhanced BAFF Signaling in SSc B Lymphocytes. Matsushita T, Hasegawa M, Yanaba K, Kodera M, Takehara K, Sato S ARTHRITIS AND RHEUMATISM 54 192-201 2006/02
- Inhibitory Role of CD19 in the Progression of Experimental Autoimmune Encephalomyelitis by Regulating Cytokine Response. Matsushita T, Fujimoto M, Hasegawa M, Komura K, Takehara K, Tedder TF, Sato S AMERICAN JOURNAL OF PATHOLOGY 168 812-21 2006/08
- A novel splenic B1 regulatory cell subset suppresses an allergic disease via PI3K-Akt pathway activation. Matsushita T, Le Huu D, Kobayashi T, Hamaguchi Y, Hasegawa M, Naka K, Hirao A, Muramatsu M, Takehara K, Fujimoto M J Allergy Clin Immunol. 138 4 1170-1182 2016
- Decreased Levels of Regulatory B cells in Patients with Systemic Sclerosis: Association with autoantibody production and disease activity. Matsushita T, Hamaguchi Y, Hasegawa M, Takehara K, Fujimoto M Rheumatology (Oxford). 55 2 263-7 2016
- Autoantibodies to Small Ubiquitin-Like Modifier Activating Enzymes in Japanese Patients with Dermatomyositis. Fujimoto, Manabu;Matsushita, Takashi;Hamaguchi, Yasuhito;Kaji, Kenzo;Hasegawa, Minoru;Takehara, Kazuhiko ARTHRITIS AND RHEUMATISM 64 10 S97-S97 2012
- High prevalence of primary biliary cirrhosis and disease-associated autoantibodies in Japanese patients with systemic sclerosis Imura-Kumada, Sayako; Hasegawa, Minoru; Matsushita, Takashi; Hamaguchi, Yasuhito; Encabo, Susan; Shums, Zakera; Norman, Gary Lewis; Takehara, Kazuhiko; Fujimoto, Manabu Modern Rheumatology 22 6 892-898 2012/11/01
- Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease. Le Huu, Doanh; Matsushita, Takashi; Jin, Guihua; Hamaguchi, Yasuhito; Hasegawa, Minoru; Takehara, Kazuhiko; Tedder, Thomas F.; Fujimoto, Manabu Blood 121 16 3274-3283 2013/04/18
- Dermokine inhibits ELR+CXC chemokine expression and delays early skin wound healing Hasegawa, Minoru; Higashi, Kiyoshi; Matsushita, Takashi; Hamaguchi, Yasuhito; Saito, Koichi; Fujimoto, Manabu; Takehara, Kazuhiko Journal of Dermatological Science 70 1 34-41 2013/04/01
- Common and Distinct Clinical Features in Adult Patients with Anti-Aminoacyl-tRNA Synthetase Antibodies: Heterogeneity within the Syndrome Hamaguchi, Yasuhito; Fujimoto, Manabu; Matsushita, Takashi; Kaji, Kenzo; Komura, Kazuhiro; Hasegawa, Minoru; Kodera, Masanari; Muroi, Eiji; Fujikawa, Keita; Seishima, Mariko; Yamada, Hidehiro; Yamada, Ryo; Sato, Shinichi; Takehara, Kazuhiko; Kuwana, Masataka PLoS ONE 8 4 2013/04/03
- Blockade of Syk ameliorates the development of murine sclerodermatous chronic graft-versus-host disease Le Huu, Doanh; Kimura, Hiroshi; Date, Mutsumi; Hamaguchi, Yasuhito; Hasegawa, Minoru; Hau, Khangtran; Fujimoto, Manabu; Takehara, Kazuhiko; Matsushita, Takashi Journal of Dermatological Science 74 3 214-221 2014/01/01
- Basophils and mast cells play critical roles for leukocyte recruitment in IgE-mediated cutaneous reverse passive Arthus reaction Jin, Guihua; Matsushita, Takashi; Hamaguchi, Yasuhito; Le Huu, Doanh; Ishii, Takayuki; Hasegawa, Minoru; Obata, Kazushige; Karasuyama, Hajime; Takehara, Kazuhiko; Fujimoto, Manabu Journal of Dermatological Science 67 3 181-189 2012/09/01
- Augmented ICOS expression in patients with early diffuse cutaneous systemic sclerosis Hasegawa, Minoru; Fujimoto, Manabu; Matsushita, Takashi; Hamaguchi, Yasuhito; Takehara, Kazuhiko Rheumatology (United Kingdom) 52 2 242-251 2013/02/01
- Anti-NXP2 autoantibodies in adult patients with idiopathic inflammatory myopathies: Possible association with malignancy Ichimura, Yuki; Matsushita, Takashi; Hamaguchi, Yasuhito; Kaji, Kenzo; Hasegawa, Minoru; Tanino, Yoshinori; Inokoshi, Yayoi; Kawai, Kazuhiro; Kanekura, Takuro; Habuchi, Maria; Igarashi, Atsuyuki; Sogame, Ryosuke; Hashimoto, Takashi; Koga, Tomohiro; Nishino, Ayako; Ishiguro, Naoko; Sugimoto, Naoki; Aoki, Rui; Ando, Noriko; Abe, Tetsuya; Kanda, Takashi; Kuwana, Masataka; Takehara, Kazuhiko; Fujimoto, Manabu Annals of the Rheumatic Diseases 71 5 710-713 2012/05/01
- Altered expression of dermokine in skin disorders Hasegawa, Minoru; Higashi, Kiyoshi; Yokoyama, Chikako; Yamamoto, Fumiichiro; Tachibana, Taro; Matsushita, Takashi; Hamaguchi, Yasuhito; Saito, Koichi; Fujimoto, Manabu; Takehara, Kazuhiko Journal of the European Academy of Dermatology and Venereology 27 7 867-875 2013/07/01
- B cells promote tumor immunity against B16F10 melanoma Kobayashi, Tadahiro; Hamaguchi, Yasuhito; Hasegawa, Minoru; Fujimoto, Manabu; Takehara, Kazuhiko; Matsushita, Takashi American Journal of Pathology 184 11 3120-3129 2014/01/01
- The clinical characteristics of juvenile-onset systemic sclerosis in Japanese patients Hatta, Yuri; Hasegawa, Minoru; Matsushita, Takashi; Hamaguchi, Yasuhito; Fujimoto, Manabu; Takehara, Kazuhiko Modern Rheumatology 1-3 2013/04/29
- Scleroderma: Recent lessons from murine models and implications for future therapeutics Matsushita, Takashi; Fujimoto, Manabu Expert Review of Dermatology 8 5 527-539 2013/11/01
- Roles of ICOS-ICOSL pathway in cutaneous wound healing Maeda, Shintaro; Fujimoto, Manabu; Matsushita, Takashi; Hamaguchi, Yasuhito; Takehara, Kazuhiko; Hasegawa, Minoru Skin Research 11 SUPPL. 17 7-13 2012/03/01
- Regulatory B cells in mouse models of systemic lupus erythematosus (SLE) Matsushita, Takashi Methods in Molecular Biology 1190 195-205 2014/01/01
- Primary Cutaneous NK/T-cell lymphoma, nasal type and cd56-positive peripheral t-cell lymphoma A cellular lineage and clinicopathologic study of 60 patients from Asia Takata, Katsuyoshi; Hong, Mineui; Sitthinamsuwan, Panitta; Loong, Florence; Tan, Sooyong; Liau, Jauyu; Hsieh, Pinpen; Ng, Siokbian; Yang, Sheaufang; Pongpruttipan, Tawatchai; Sukpanichnant, Sanya; Kwong, Yoklam; Ko, Younghyeh; Cho, Yungtsu; Chng, Wee Joo; Matsushita, Takashi; Yoshino, Tadashi; Chuang, Shihsung American Journal of Surgical Pathology 39 1 1-12 2014/01/01
- Potential roles of interleukin-17A in the development of skin fibrosis in mice Okamoto, Yoshinobu; Hasegawa, Minoru; Matsushita, Takashi; Hamaguchi, Yasuhito; Huu, Doanh Le; Iwakura, Yoichiro; Fujimoto, Manabu; Takehara, Kazuhiko Arthritis and Rheumatism 64 11 3726-3735 2012/11/01
- Myositis-specific anti-155/140 autoantibodies target transcription intermediary factor 1 family proteins Fujimoto, Manabu; Hamaguchi, Yasuhito; Kaji, Kenzo; Matsushita, Takashi; Ichimura, Yuki; Kodera, Masanari; Ishiguro, Naoko; Ueda-Hayakawa, Ikuko; Asano, Yoshihide; Ogawa, Fumihide; Fujikawa, Keita; Miyagi, Takuya; Mabuchi, Eriko; Hirose, Kenji; Akimoto, Narihiro; Hatta, Naohito; Tsutsui, Kiyohiro; Higashi, Akira; Igarashi, Atsuyuki; Seishima, Mariko; Hasegawa, Minoru; Takehara, Kazuhiko Arthritis and Rheumatism 64 2 513-522 2012/02/01
- Inducible costimulator (ICOS) and ICOS ligand signaling has pivotal roles in skin wound healing via cytokine production Maeda, Shintaro; Fujimoto, Manabu; Matsushita, Takashi; Hamaguchi, Yasuhito; Takehara, Kazuhiko; Hasegawa, Minoru American Journal of Pathology 179 5 2360-2369 2011/11/01
- Host-derived MCP-1 and MIP-1α regulate protective anti-tumor immunity to localized and metastatic B16 melanoma Nakasone, Yuko; Fujimoto, Manabu; Matsushita, Takashi; Hamaguchi, Yasuhito; Huu, Doanh Le; Yanaba, Mizuki; Sato, Shinichi; Takehara, Kazuhiko; Hasegawa, Minoru American Journal of Pathology 180 1 365-374 2012/01/01
- Augmented Expression of Inducible Costimulator (ICOS) and Its Ligand (ICOSL) in Patients with Systemic Sclerosis Hasegawa, Minoru;Fujimoto, Manabu;Matsushita, Takashi;Hamaguchi, Yasuhito;Takehara, Kazuhiko ARTHRITIS AND RHEUMATISM 63 10 S581-S582 2011
- FTY720 ameliorates murine Scl-cGVHD by promoting expansion of splenic regulatory cells and inhibiting immune cell infiltration into the skin Matsushita, Takashi;Le Huu, Doanh;Takehara, Kazuhiko;Fujimoto, Manabu JOURNAL OF IMMUNOLOGY 190 0 0-0 2013
- Primary Cutaneous NK/T-cell Lymphoma, Nasal Type and CD56-positive Peripheral T-cell Lymphoma A Cellular Lineage and Clinicopathologic Study of 60 Patients From Asia Takata, Katsuyoshi;Hong, Min-eui;Sitthinamsuwan, Panitta;Loong, Florence;Tan, Soo-Yong;Liau, Jau-Yu;Hsieh, Pin-Pen;Ng, Siok-Bian;Yang, Sheau-Fang;Pongpruttipan, Tawatchai;Sukpanichnant, Sanya;Kwong, Yok-Lam;Ko, Young Hyeh;Cho, Yung-Tsu;Chng, Wee Joo;Matsushita, Takashi;Yoshino, Tadashi;Chuang, Shih-Sung AMERICAN JOURNAL OF SURGICAL PATHOLOGY 39 1 1-12 2015/01/01
- IL-6 Blockade Attenuates the Development of Murine Sclerodermatous Chronic Graft-Versus-Host Disease Doanh Le Huu;Matsushita, Takashi;Jin, Guihua;Hamaguchi, Yasuhito;Hasegawa, Minoru;Takehara, Kazuhiko;Fujimoto, Manabu JOURNAL OF INVESTIGATIVE DERMATOLOGY 132 12 2752-2761 2012
- Serum chemokine and cytokine levels as indicators of disease activity in patients with systemic sclerosis Hasegawa, Minoru;Fujimoto, Manabu;Matsushita, Takashi;Hamaguchi, Yasuhito;Takehara, Kazuhiko;Sato, Shinichi CLINICAL RHEUMATOLOGY 30 2 231-237 2011
- Clinical Correlations With Dermatomyositis-Specific Autoantibodies in Adult Japanese Patients With Dermatomyositis A Multicenter Cross-sectional Study Hamaguchi, Yasuhito;Kuwana, Masataka;Hoshino, Kana;Hasegawa, Minoru;Kaji, Kenzo;Matsushita, Takashi;Komura, Kazuhiro;Nakamura, Motonobu;Kodera, Masanari;Suga, Norihiro;Higashi, Akira;Ogusu, Koji;Tsutsui, Kiyohiro;Furusaki, Akira;Tanabe, Hiroshi;Sasaoka, Shunsuke;Muro, Yoshinao;Yoshikawa, Mika;Ishiguro, Naoko;Ayano, Masahiro;Muroi, Eiji;Fujikawa, Keita;Umeda, Yukihiro;Kawase, Masaaki;Mabuchi, Eriko;Asano, Yoshihide;Sodemoto, Kinuyo;Seishima, Mariko;Yamada, Hidehiro;Sato, Shinichi;Takehara, Kazuhiko;Fujimoto, Manabu ARCHIVES OF DERMATOLOGY 147 4 391-398 2011
- Association between nail-fold capillary findings and disease activity in dermatomyositis Mugii, Naoki;Hasegawa, Minoru;Matsushita, Takashi;Hamaguchi, Yasuhito;Horie, Sho;Yahata, Tetsutarou;Inoue, Katsumi;Someya, Fujiko;Fujimoto, Manabu;Takehara, Kazuhiko RHEUMATOLOGY 50 6 1091-1098 2011
- Use of Serum Clara Cell 16-kDa (CC16) Levels as a Potential Indicator of Active Pulmonary Fibrosis in Systemic Sclerosis Hasegawa, Minoru;Fujimoto, Manabu;Hamaguchi, Yasuhito;Matsushita, Takashi;Inoue, Katsumi;Sato, Shinichi;Takehara, Kazuhiko JOURNAL OF RHEUMATOLOGY 38 5 877-884 2011
- Scleroderma: recent lessons from murine models and implications for future therapeutics． Matsushita T, et al. Expert Review of Dermatology in press 2013/10
- Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease. Le Huu D, Matsushita T (corresponding author), et al. BLOOD 121 3274-3283 2013/01
- FTY720 ameliorates murine Scl-cGVHD by promoting expansion of splenic regulatory cells and inhibiting immune cell infiltration into skin. Le Huu D, Matsushita T (corresponding author), et al ARTHRITIS AND RHEUMATISM 65 1624-1635 2013/01
- IL-6 blockade attenuates the development of murine sclerodermatous chronic graft-versus-host disease. Le Huu D, Matsushita T (corresponding author), et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY 132 2752-2761 2012/01
- Autoantibody against matrix metalloproteinase-3 in patients with systemic sclerosis C. Nishijima,I. Hayakawa,T. Matsushita,K. Komura,M. Hasegawa,K. Takehara,Shinichi Sato Clinical and Experimental Immunology 138 2 357 2004/11
- Identification of a novel autoantibody reactive with 155 and 140 kDa nuclear proteins in patients with dermatomyositis: An association with malignancy K. Kaji,M. Fujimoto,M. Hasegawa,M. Kondo,Y. Saito,K. Komura,T. Matsushita,H. Orito,Y. Hamaguchi,K. Yanaba,M. Itoh,Y. Asano,M. Seishima,F. Ogawa,S. Sato,K. Takehara Rheumatology 46 1 25 2007/01
- The efficacy of self-administered stretching for finger joint motion in Japanese patients with systemic sclerosis Naoki Mugii,Minoru Hasegawa,Takashi Matsushita,Miki Kondo,Hidemitsu Orito,Koichi Yanaba,Kazuhiro Komura,Ikuko Hayakawa,Yasuhito Hamaguchi,Munehiro Ikuta,Katsuhiko Tachino,Manabu Fujimoto,Kazuhiko Takehara,Shinichi Sato Journal of Rheumatology 33 8 1586 2006/08
- Longitudinal analysis of serum cytokine concentrations in systemic sclerosis: Association of interleukin 12 elevation with spontaneous regression of skin sclerosis Takashi Matsushita,Minoru Hasegawa,Yasuhito Hamaguchi,Kazuhiko Takehara,Shinichi Sato Journal of Rheumatology 33 2 275 2006/02
- Serum levels of monocyte chemotactic protein-3/CCL7 are raised in patients with systemic sclerosis: Association with extent of skin sclerosis and severity of pulmonary fibrosis K. Yanaba,K. Komura,M. Kodera,T. Matsushita,M. Hasegawa,K. Takehara,S. Sato Annals of the Rheumatic Diseases 65 1 124 2006/01
- Serum soluble CTLA-4 levels are increased in diffuse cutaneous systemic sclerosis S. Sato,M. Fujimoto,M. Hasegawa,K. Komura,K. Yanaba,I. Hayakawa,T. Matsushita,K. Takehara Rheumatology 43 10 1261 2004/10
- L-selectin and intercellular adhesion molecule-1 regulate the development of Concanavalin A-induced liver injury Ayako Kawasuji,Minoru Hasegawa,Mayuka Horikawa,Tomoyuki Fujita,Yukiyo Matsushita,Takashi Matsushita,Manabu Fujimoto,Douglas A. Steeber,Thomas F. Tedder,Kazuhiko Takehara,Shinichi Sato Journal of Leukocyte Biology 79 4 696 2006/04
- Regulation of local and metastatic host-mediated anti-tumour mechanisms by L-selectin and intercellular adhesion molecule-1 M. Yamada,K. Yanaba,M. Hasegawa,Y. Matsushita,M. Horikawa,K. Komura,T. Matsushita,A. Kawasuji,T. Fujita,K. Takehara,D. A. Steeber,T. F. Tedder,S. Sato Clinical and Experimental Immunology 143 2 216 2006/02
- Anti-phosphatidylserine-prothrombine complex antibodies in patients with localized scleroderma Minoru Hasegawa,Manabu Fujimoto,Ikuko Hayakawa,Takashi Matsushita,Chihiro Nishijima,Masahide Yamazaki,Kazuhiko Takehara,Shinichi Sato Clinical and Experimental Rheumatology 24 1 19 2006/01
- Elevated serum BAFF levels in patients with systemic sclerosis: Enhanced BAFF signaling in systemic sclerosis B lymphocytes Takashi Matsushita,Minoru Hasegawa,Koichi Yanaba,Masanari Kodera,Kazuhiko Takehara,Shinichi Sato Arthritis and Rheumatism 54 1 192 2006/01
- The role of BAFF in autoimmune diseases Takashi Matsushita,Shinichi Sato Japanese Journal of Clinical Immunology 28 5 333 2005
- Increased cutaneous T-cell-attracting chemokine levels in sera from patients with systemic sclerosis I. Hayakawa,Minoruha Hasegawa,T. Matsushita,K. Yanaba,M. Kodera,K. Komura,K. Takehara,S. Sato Rheumatology 44 7 873 2005/07
- Epstein-Barr virus-associated T-cell lymphoma: A case of eyelid swelling and intramuscular infiltration mimicking dermatomyositis Fumiaki Shirasaki,K. Taniuchi,T. Matsushita,Y. Hamaguhi,M. Takata,K. Takehara British Journal of Dermatology 147 6 1244 2002/12/01
- Abnormal natural killer cell function in systemic sclerosis: Altered cytokine production and defective killing activity Mayuka Horikawa,Minoru Hasegawa,Kazuhiro Komura,Ikuko Hayakawa,Koichi Yanaba,Takashi Matsushita,Kazuhiko Takehara,Shinichi Sato Journal of Investigative Dermatology 125 4 731 2005/10
- Inhibitory role of CD19 in the progression of experimental autoimmune encephalomyelitis by regulating cytokine response Takashi Matsushita,Manabu Fujimoto,Minoru Hasegawa,Kazuhiro Komura,Kazuhiko Takehara,Thomas F. Tedder,Shinichi Sato American Journal of Pathology 168 3 812 2006/03
- A clue for telangiectasis in systemic sclerosis: Elevated serum soluble endoglin levels in patients with the limited cutaneous form of the disease M. Fujimoto,M. Hasegawa,Y. Hamaguchi,K. Komura,T. Matsushita,K. Yanaba,M. Kodera,K. Takehara,S. Sato Dermatology 213 2 88 2006/08
- E- and P-selectins synergistically inhibit bleomycin-induced pulmonary fibrosis Mayuka Horikawa,Manabu Fujimoto,Minoru Hasegawa,Takashi Matsushita,Yasuhito Hamaguchi,Ayako Kawasuji,Yukiyo Matsushita,Tomoyuki Fujita,Fumihide Ogawa,Kazuhiko Takehara,Douglas A. Steeber,Shinichi Sato American Journal of Pathology 169 3 740 2006/09
- B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis Minoru Hasegawa,Yasuhito Hamaguchi,Koichi Yanaba,Jean David Bouaziz,Junji Uchida,Manabu Fujimoto,Takashi Matsushita,Yukiyo Matsushita,Mayuka Horikawa,Kazuhiro Komura,Kazuhiko Takehara,Shinichi Sato,Thomas F. Tedder American Journal of Pathology 169 3 954 2006/09
- Clinical evaluation of anti-aminoacyl tRNA synthetase antibodies in Japanese patients with dermatomyositis Takashi Matsushita,Minoru Hasegawa,Manabu Fujimoto,Yasuhito Hamaguchi,Kazuhiro Komura,Takashi Hirano,Mayuka Horikawa,Miki Kondo,Hidemitsu Orito,Kenzo Kaji,Yuki Saito,Yukiyo Matsushita,Shigeru Kawara,Masahide Yasui,Mariko Seishima,Shoichi Ozaki,Masataka Kuwana,Fumihide Ogawa,Shinichi Sato,Kazuhiko Takehara Journal of Rheumatology 34 5 1012 2007/05
- Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1 Toru Yukami,Minoru Hasegawa,Yukiyo Matsushita,Tomoyuki Fujita,Takashi Matsushita,Mayuka Horikawa,Kazuhiro Komura,Koichi Yanaba,Yasuhito Hamaguchi,Tetsuya Nagaoka,Fumihide Ogawa,Manabu Fujimoto,Douglas A. Steeber,Thomas F. Tedder,Kazuhiko Takehara,Shinichi Sato Journal of Leukocyte Biology 82 3 519 2007/09/01
- Elevated serum BAFF levels in patients with localized scleroderma in contrast to other organ-specific autoimmune diseases Takashi Matsushita,Minoru Hasegawa,Yukiyo Matsushita,Takeshi Echigo,Takamasa Wayaku,Mayuka Horikawa,Fumihide Ogawa,Kazuhiko Takehara,Shinichi Sato Experimental Dermatology 16 2 87 2007/02
- Antigen specificity of antihistone antibodies in connective tissue disease patients with anti-U1RNP antibodies Takamasa Wayaku,Minoru Hasegawa,Kenzo Kaji,Miki Kondo,Yuki Saito,Hidemitsu Orito,Mayuka Horikawa,Takashi Matsushita,Kazuhiro Komura,Ikuko Hayakawa,Yasuhito Hamaguchi,Fumihide Ogawa,Manabu Fujimoto,Kazuhiko Takehara,Shinichi Sato Rheumatology International 28 2 113 2007/12
- A case of acute cutaneous graft-versus-host disease mimicking psoriasis vulgaris Takashi Matsushita,Minoru Hasegawa,Fumiaki Shirasaki,Manabu Fujimoto,Hirohito Yamazaki,Shinichi Sato,Kazuhiko Takehara Dermatology 216 1 64 2007/11
- Elevated serum APRIL levels in patients with systemic sclerosis: Distinct profiles of systemic sclerosis categorized by APRIL and BAFF Takashi Matsushita,Manabu Fujimoto,Minoru Hasegawa,Chihiro Tanaka,Sayako Kumada,Fumihide Ogawa,Kazuhiko Takehara,Shinichi Sato Journal of Rheumatology 34 10 2056 2007/10
- BAFF antagonist attenuates the development of skin fibrosis in tight-skin mice Takashi Matsushita,Manabu Fujimoto,Minoru Hasegawa,Yukiyo Matsushita,Kazuhiro Komura,Fumihide Ogawa,Rei Watanabe,Kazuhiko Takehara,Shinichi Sato Journal of Investigative Dermatology 127 12 2772 2007/12
- Increased serum soluble CD40 levels in patients with systemic sclerosis Kazuhiro Komura,Manabu Fujimoto,Takashi Matsushita,Koichi Yanaba,Masanari Kodera,Ayako Kawasuji,Minoru Hasegawa,Kazuhiko Takehara,Shinichi Sato Journal of Rheumatology 34 2 353 2007/02
- Intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 cooperatively contribute to the cutaneous Arthus reaction Hidemitsu Orito,Manabu Fujimoto,Nobuko Ishiura,Koichi Yanaba,Takashi Matsushita,Minoru Hasegawa,Fumihide Ogawa,Kazuhiko Takehara,Shinichi Sato Journal of Leukocyte Biology 81 5 1197 2007/05
- Phase-dependent roles of E-selectin during chronic contact hypersensitivity responses Tomoyuki Fujita,Manabu Fujimoto,Takashi Matsushita,Yuka Shimada,Minoru Hasegawa,Yoshihiro Kuwano,Fumihide Ogawa,Kazuhiko Takehara,Shinichi Sato American Journal of Pathology 170 5 1649 2007/05
- Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice Yukiyo Matsushita,Minoru Hasegawa,Takashi Matsushita,Manabu Fujimoto,Mayuka Horikawa,Tomoyuki Fujita,Ayako Kawasuji,Fumihide Ogawa,Douglas A. Steeber,Thomas F. Tedder,Kazuhiko Takehara,Shinichi Sato Journal of Immunology 179 1 698 2007/07/01
- Two cases of livedo vasculopathy with non-criteria antiphospholipid antibodies Minoru Hasegawa,Manabu Fujimoto,Hidemitsu Orito,Takashi Matsushita,Yasuhito Hamaguchi,Kazuhiko Takehara Journal of Dermatology 39 12 1026 2012/12
- Potential roles of interleukin-17A in the development of skin fibrosis in mice Yoshinobu Okamoto,Minoru Hasegawa,Takashi Matsushita,Yasuhito Hamaguchi,Doanh Le Huu,Yoichiro Iwakura,Manabu Fujimoto,Kazuhiko Takehara Arthritis and Rheumatism 64 11 3726 2012/11
- IL-6 blockade attenuates the development of murine sclerodermatous chronic graft-versus-host disease Doanh Le Huu,Takashi Matsushita,Guihua Jin,Yasuhito Hamaguchi,Minoru Hasegawa,Kazuhiko Takehara,Manabu Fujimoto Journal of Investigative Dermatology 132 12 2752 2012/12
- Skin sclerosis as a manifestation of POEMS syndrome Minoru Hasegawa,Hidemitsu Orito,Keiko Yamamoto,Takashi Matsushita,Yasuhito Hamaguchi,Manabu Fujimoto,Kazuhiko Takehara Journal of Dermatology 39 11 922 2012/11
- High prevalence of primary biliary cirrhosis and disease-associated autoantibodies in Japanese patients with systemic sclerosis Sayako Imura-Kumada,Minoru Hasegawa,Takashi Matsushita,Yasuhito Hamaguchi,Susan Encabo,Zakera Shums,Gary L. Norman,Kazuhiko Takehara,Manabu Fujimoto Modern Rheumatology 22 6 892 2012/11
- Basophils and mast cells play critical roles for leukocyte recruitment in IgE-mediated cutaneous reverse passive Arthus reaction Guihua Jin,Takashi Matsushita,Yasuhito Hamaguchi,Doanh Le Huu,Takayuki Ishii,Minoru Hasegawa,Kazushige Obata,Hajime Karasuyama,Kazuhiko Takehara,Manabu Fujimoto Journal of Dermatological Science 67 3 181 2012/09
- A crucial role of L-selectin in C protein-induced experimental polymyositis in mice Kyosuke Oishi,Yasuhito Hamaguchi,Takashi Matsushita,Minoru Hasegawa,Naoko Okiyama,Jens Dernedde,Marie Weinhart,Rainer Haag,Thomas F. Tedder,Kazuhiko Takehara,Hitoshi Kohsaka,Manabu Fujimoto Arthritis and Rheumatology 66 7 1864 2014/07
Conference Presentations
- A unique CD9+CD80+ regulatory B cell inhibits contact hypersensitivity response.(conference： JSID 2016)
- A novel splenic B1 regulatory B cell subset with a unique CD9+CD80+ phenotype suppresses an allergic disease via PI3K-Akt pathway activation. (conference：ESDR 2016)(2016)
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「サイトカイン産生B細胞の制御による強皮症の新規治療法の開発」(2019-2021)
○「全身性強皮症におけるEffector B細胞の役割についての検討」(2017-2019)
○「強皮症モデルマウスにおけるサイトカイン産生B細胞の役割」(2016-2018)
○「全身性強皮症ならびに強皮症モデルマウスにおけるSyk阻害剤の有効性の検討」(2014-2016)
○「全身性強皮症におけるregulatory B細胞の機能解析および新規治療法の開発」(2013-2015)
○「制御性B細胞におけるPI3Kシグナルによる制御機構の解析」(2011-2012)
○「全身性強皮症患者および線維化モデルマウスにおける制御性Ｂ細胞の解析」(2011-2013)
○「Sclerodermatous GVHDマウスにおける制御性B細胞の役割」(2010-2010)
○「BAFFアンタゴニストによる強皮症モデルマウスの治療」(2006-2007)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
Classes (Graduate Schools)
○Angiogenesis and Connective Tissue Metabolism(2017)
○Angiogenesis and Connective Tissue Metabolism(2017)
○Angiogenesis and Connective Tissue Metabolism(2016)
○Angiogenesis and Connective Tissue Metabolism(2016)