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last modified：2025/04/09
Professor NAITO, Hisamichi
Faculty, Affiliation
Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences
College and School Educational Field
Laboratory
Academic Background
Career
Kanazawa University Department of Vascular Molecular Physiology, Kanazawa University School of Medicine Professor(2021/04-)
Osaka University Research Institute for Microbial Diseases(2019/04-2021/03)
Osaka University Research Institute for Microbial Diseases(2012/04-2019/03)
(2003/06-2005/03)
(2002/05-2003/06)
Year & Month of Birth
Academic Society
THE JAPANESE SOCIETY OF INTERNAL MEDICINE
The Japanese Vascular Biology and Medicine Organization
THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
Award
THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
Specialities
、、、、
Speciality Keywords
Research Themes
Books
Papers
- Mechanisms of new blood-vessel formation and proliferative heterogeneity of endothelial cells. Hisamichi Naito,Tomohiro Iba,Nobuyuki Takakura International immunology 32 5 295 2020/05/08
- Isolation of tissue-resident vascular endothelial stem cells from mouse liver. Hisamichi Naito,Taku Wakabayashi,Masako Ishida,Chang-Hyun Gil,Tomohiro Iba,Fitriana Nur Rahmawati,Shota Shimizu,Mervin C Yoder,Nobuyuki Takakura Nature protocols 15 3 1066 2020/03
- TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity. Hisamichi Naito,Tomohiro Iba,Taku Wakabayashi,Ikue Tai-Nagara,Jun-Ichi Suehiro,Weizhen Jia,Daisuke Eino,Susumu Sakimoto,Fumitaka Muramatsu,Hiroyasu Kidoya,Hiroyuki Sakurai,Takashi Satoh,Shizuo Akira,Yoshiaki Kubota,Nobuyuki Takakura Developmental cell 48 2 151 2019/01/28
- CD157 Marks Tissue-Resident Endothelial Stem Cells with Homeostatic and Regenerative Properties Taku Wakabayashi,Hisamichi Naito,Jun-ichi Suehiro,Yang Lin,Hideya Kawaji,Tomohiro Iba,Tsukasa Kouno,Sachi Ishikawa-Kato,Masaaki Furuno,Kazuhiro Takara,Fumitaka Muramatsu,Jia Weizhen,Hiroyasu Kidoya,Katsuhiko Ishihara,Yoshihide Hayashizaki,Kohji Nishida,Mervin C. Yoder,Nobuyuki Takakura Cell Stem Cell 22 3 384 2018/03/01
- Endothelial Side Population Cells Contribute to Tumor Angiogenesis and Antiangiogenic Drug Resistance Hisamichi Naito,Taku Wakabayashi,Hiroyasu Kidoya,Fumitaka Muramatsu,Kazuhiro Takara,Daisuke Eino,Keitaro Yamane,Tomohiro Iba,Nobuyuki Takakura CANCER RESEARCH 76 11 3200 2016/06
- Identification and characterization of a resident vascular stem/progenitor cell population in preexisting blood vessels Hisamichi Naito,Hiroyasu Kidoya,Susumu Sakimoto,Taku Wakabayashi,Nobuyuki Takakura EMBO JOURNAL 31 4 842 2012/02
- Isolation of tissue-resident endothelial stem cells and their use in regenerative medicine. Iba T,Naito H,Shimizu S,Rahmawati FN,Wakabayashi T,Takakura N Inflammation and regeneration 39 9 2019
- Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis. Hiroyasu Kidoya,Fumitaka Muramatsu,Teppei Shimamura,Weizhen Jia,Takashi Satoh,Yumiko Hayashi,Hisamichi Naito,Yuya Kunisaki,Fumio Arai,Masahide Seki,Yutaka Suzuki,Tsuyoshi Osawa,Shizuo Akira,Nobuyuki Takakura Nature communications 10 1 1072 2019/03/06
- TAK1 safeguards endothelial cells from gut microbes and inflammation. Naito H,Takakura N Molecular & cellular oncology 6 3 1588657 2019
- Schlafen-8 is essential for lymphatic endothelial cell activation in experimental autoimmune encephalomyelitis Katsuhiro Nakagawa,Takanori Matsuki,Liang Zhao,Kanako Kuniyoshi,Hiroki Tanaka,Isao Ebina,Kenta J. Yoshida,Hiroshi Nabeshima,Kiyoharu Fukushima,Hisashi Kanemaru,Fumihiro Yamane,Takahiro Kawasaki,Tomohisa Machida,Hisamichi Naito,Nobuyuki Takakura,Takashi Satoh,Shizuo Akira International Immunology 30 2 69 2018/03/08
- LPA4-Mediated Vascular Network Formation Increases the Efficacy of Anti-PD-1 Therapy against Brain Tumors. Eino D,Tsukada Y,Naito H,Kanemura Y,Iba T,Wakabayashi T,Muramatsu F,Kidoya H,Arita H,Kagawa N,Fujimoto Y,Takara K,Kishima H,Takakura N Cancer research 78 23 6607 2018/12
- Fluorescence and Bioluminescence Imaging of Angiogenesis in Flk1-Nano-lantern Transgenic Mice. Jun Matsushita,Shigenori Inagaki,Tomomi Nishie,Tomoki Sakasai,Junko Tanaka,Chisato Watanabe,Ken-Ichi Mizutani,Yoshihiro Miwa,Ken Matsumoto,Kazuhiro Takara,Hisamichi Naito,Hiroyasu Kidoya,Nobuyuki Takakura,Takeharu Nagai,Satoru Takahashi,Masatsugu Ema Scientific reports 7 46597 2017/04/20
- Lysophosphatidic Acid Receptor 4 Activation Augments Drug Delivery in Tumors by Tightening Endothelial Cell-Cell Contact Kazuhiro Takara,Daisuke Eino,Koji Ando,Daisuke Yasuda,Hisamichi Naito,Yohei Tsukada,Tomohiro Iba,Taku Wakabayashi,Fumitaka Muramatsu,Hiroyasu Kidoya,Shigetomo Fukuhara,Naoki Mochizuki,Satoshi Ishii,Haruhiko Kishima,Nobuyuki Takakura CELL REPORTS 20 9 2072 2017/08
- Plakoglobin maintains the integrity of vascular endothelial cell junctions and regulates VEGF-induced phosphorylation of VE-cadherin Fumitaka Muramatsu,Hiroyasu Kidoya,Hisamichi Naito,Yumiko Hayashi,Tomohiro Iba,Nobuyuki Takakura JOURNAL OF BIOCHEMISTRY 162 1 55 2017/07
- Gas6 derived from cancer-associated fibroblasts promotes migration of Axl-expressing lung cancer cells during chemotherapy Ryu Kanzaki,Hisamichi Naito,Kazuyoshi Kise,Kazuhiro Takara,Daisuke Eino,Masato Minami,Yasushi Shintani,Soichiro Funaki,Tomohiro Kawamura,Toru Kimura,Meinoshin Okumura,Nobuyuki Takakura SCIENTIFIC REPORTS 7 1 10613 2017/09
- Soluble HLA-associated peptide from PSF1 has a cancer vaccine potency Mari Yoshida,Yukichi Ishioka,Takamasa Ozawa,Hirohisa Okuyama,Motofumi Iguchi,Takeshi Ota,Takaomi Ito,Morio Nagira,Atsushi Morita,Hidekazu Tanaka,Hisamichi Naito,Hiroyasu Kidoya,Nobuyuki Takakura SCIENTIFIC REPORTS 7 1 11137 2017/09
- PSF1 (Partner of SLD Five 1) is a Prognostic Biomarker in Patients with Non-small Cell Lung Cancer Treated with Surgery Following Preoperative Chemotherapy or Chemoradiotherapy Ryu Kanzaki,Hisamichi Naito,Kazuyoshi Kise,Kazuhiro Takara,Daisuke Eino,Masato Minami,Yasushi Shintani,Soichiro Funaki,Tomohiro Kawamura,Toru Kimura,Meinoshin Okumura,Nobuyuki Takakura ANNALS OF SURGICAL ONCOLOGY 23 12 4093 2016/11
- Regulation of SLD5 gene expression by miR-370 during acute growth of cancer cells Keitaro Yamane,Hisamichi Naito,Taku Wakabayashi,Hironori Yoshida,Fumitaka Muramatsu,Tomohiro Iba,Hiroyasu Kidoya,Nobuyuki Takakura SCIENTIFIC REPORTS 6 30941 2016/08
- Evaluation of PSF1 as a prognostic biomarker for prostate cancer H. Tahara,H. Naito,K. Kise,T. Wakabayashi,K. Kamoi,K. Okihara,A. Yanagisawa,Y. Nakai,N. Nonomura,E. Morii,T. Miki,N. Takakura PROSTATE CANCER AND PROSTATIC DISEASES 18 1 56 2015/03
- Cell-sheet therapy with omentopexy promotes arteriogenesis and improves coronary circulation physiology in failing heart. Satoshi Kainuma,Shigeru Miyagawa,Satsuki Fukushima,James Pearson,Yi Ching Chen,Atsuhiro Saito,Akima Harada,Motoko Shiozaki,Hiroko Iseoka,Tadashi Watabe,Hiroshi Watabe,Genki Horitsugi,Mana Ishibashi,Hayato Ikeda,Hirotsugu Tsuchimochi,Takashi Sonobe,Yutaka Fujii,Hisamichi Naito,Keiji Umetani,Tatsuya Shimizu,Teruo Okano,Eiji Kobayashi,Takashi Daimon,Takayoshi Ueno,Toru Kuratani,Koichi Toda,Nobuyuki Takakura,Jun Hatazawa,Mikiyasu Shirai,Yoshiki Sawa Molecular therapy : the journal of the American Society of Gene Therapy 23 2 374 2015/02
- APJ Regulates Parallel Alignment of Arteries and Veins in the Skin Hiroyasu Kidoya,Hisamichi Naito,Fumitaka Muramatsu,Daishi Yamakawa,Weizhen Jia,Masahito Ikawa,Takashi Sonobe,Hirotsugu Tsuchimochi,Mikiyasu Shirai,Ralf H. Adams,Akiyoshi Fukamizu,Nobuyuki Takakura DEVELOPMENTAL CELL 33 3 247 2015/05
- Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages Takashi Satoh,Hiroyasu Kidoya,Hisamichi Naito,Masahiro Yamamoto,Naoki Takemura,Katsuhiro Nakagawa,Yoshichika Yoshioka,Eiichi Morii,Nobuyuki Takakura,Osamu Takeuchi,Shizuo Akira NATURE 495 7442 524 2013/03
- Vascular-resident endothelial side population cells Hisamichi Naito,Nobuyuki Takakura Angiogenesis and Vascularisation: Cellular and Molecular Mechanisms in Health and Diseases 67 2013/12/01
- Identification of vascular endothelial side population cells in the choroidal vessels and their potential role in age- related macular degeneration Taku Wakabayashi,Hisamichi Naito,Kazuhiro Takara,Hiroyasu Kidoya,Susumu Sakimoto,Yusuke Oshima,Kohji Nishida,Nobuyuki Takakura Investigative Ophthalmology and Visual Science 54 10 6686 2013
- Tumor Endothelial Cell-Specific Drug Delivery System Using Apelin-Conjugated Liposomes Hiroki Kawahara,Hisamichi Naito,Kazuhiro Takara,Taku Wakabayashi,Hiroyasu Kidoya,Nobuyuki Takakura PLOS ONE 8 6 e65499 2013/06
- An Angiogenic Role for Adrenomedullin in Choroidal Neovascularization Susumu Sakimoto,Hiroyasu Kidoya,Motohiro Kamei,Hisamichi Naito,Daishi Yamakawa,Hirokazu Sakaguchi,Taku Wakabayashi,Kohji Nishida,Nobuyuki Takakura PLOS ONE 8 3 e58096 2013/03
- Ligand-independent Tie2 Dimers Mediate Kinase Activity Stimulated by High Dose Angiopoietin-1 Daishi Yamakawa,Hiroyasu Kidoya,Susumu Sakimoto,Weizhen Jia,Hisamichi Naito,Nobuyuki Takakura JOURNAL OF BIOLOGICAL CHEMISTRY 288 18 12469 2013/05
- Galectin-3 Accelerates M2 Macrophage Infiltration and Angiogenesis in Tumors Weizhen Jia,Hiroyasu Kidoya,Daishi Yamakawa,Hisamichi Naito,Nobuyuki Takakura AMERICAN JOURNAL OF PATHOLOGY 182 5 1821 2013/05
- microRNA-125b inhibits tube formation of blood vessels through translational suppression of VE-cadherin F. Muramatsu,H. Kidoya,H. Naito,S. Sakimoto,N. Takakura ONCOGENE 32 4 414 2013/01
- Changes in blood vessel maturation in the fibrous cap of the tumor rim Hisamichi Naito,Kazuhiro Takara,Taku Wakabayashi,Hiroki Kawahara,Hiroyasu Kidoya,Nobuyuki Takakura CANCER SCIENCE 103 3 433 2012/03
- A role for endothelial cells in promoting the maturation of astrocytes through the apelin/APJ system in mice Susumu Sakimoto,Hiroyasu Kidoya,Hisamichi Naito,Motohiro Kamei,Hirokazu Sakaguchi,Nobuhito Goda,Akiyoshi Fukamizu,Kohji Nishida,Nobuyuki Takakura DEVELOPMENT 139 7 1327 2012/04
- The apelin/APJ system induces maturation of the tumor vasculature and improves the efficiency of immune therapy H. Kidoya,N. Kunii,H. Naito,F. Muramatsu,Y. Okamoto,T. Nakayama,N. Takakura ONCOGENE 31 27 3254 2012/07
- Docking Protein Gab1 Is an Essential Component of Postnatal Angiogenesis After Ischemia via HGF/c-Met Signaling Wataru Shioyama,Yoshikazu Nakaoka,Kaori Higuchi,Takashi Minami,Yoshiaki Taniyama,Keigo Nishida,Hiroyasu Kidoya,Takashi Sonobe,Hisamichi Naito,Yoh Arita,Takahiro Hashimoto,Tadashi Kuroda,Yasushi Fujio,Mikiyasu Shirai,Nobuyuki Takakura,Ryuichi Morishita,Keiko Yamauchi-Takihara,Tatsuhiko Kodama,Toshio Hirano,Naoki Mochizuki,Issei Komuro CIRCULATION RESEARCH 108 6 664 2011/03
- Apelin induces enlarged and nonleaky blood vessels for functional recovery from ischemia Hiroyasu Kidoya,Hisamichi Naito,Nobuyuki Takakura BLOOD 115 15 3166 2010/04
- Induction and Expression of Anti-Angiogenic Vasohibins in the Hematopoietic Stem/Progenitor Cell Population Hisamichi Naito,Hiroyasu Kidoya,Yasufumi Sato,Nobuyuki Takakura JOURNAL OF BIOCHEMISTRY 145 5 653 2009/05
- EphB4 overexpression in B16 melanoma cells affects arterial-venous patterning in tumor angiogenesis Xiaoyong Huang,Yoshihiro Yamada,Hiroyasu Kidoya,Hisamichi Naito,Yumi Nagahama,Lingyu Kong,Shin-Ya Katoh,Weng-Fin Li,Masaya Ueno,Nobuyuki Takakura CANCER RESEARCH 67 20 9800 2007/10
- A novel approach for myocardial regeneration with educated cord blood cells cocultured with cells from brown adipose tissue Yoshihiro Yamada,Shin-ichiro Yokoyama,Noboru Fukuda,Hiroyasu Kidoya,Xiao-Yong Huang,Hisamichi Naitoh,Naoyuki Satoh,Nobuyuki Takakura BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 353 1 182 2007/02
- Aging impairs the ability of vascular endothelial stem cells to generate endothelial cells in mice. Shota Shimizu,Tomohiro Iba,Hisamichi Naito,Fitriana Nur Rahmawati,Hirotaka Konishi,Weizhen Jia,Fumitaka Muramatsu,Nobuyuki Takakura Angiogenesis 2023/08/10
- L-carnitine prevents lenvatinib-induced muscle toxicity without impairment of the anti-angiogenic efficacy. Zheng Jing,Tomohiro Iba,Hisamichi Naito,Pingping Xu,Jun-Ichi Morishige,Naoto Nagata,Hironao Okubo,Hitoshi Ando Frontiers in pharmacology 14 1182788 2023
- Indispensable role of Galectin-3 in promoting quiescence of hematopoietic stem cells. Weizhen Jia,Lingyu Kong,Hiroyasu Kidoya,Hisamichi Naito,Fumitaka Muramatsu,Yumiko Hayashi,Han-Yun Hsieh,Daishi Yamakawa,Daniel K Hsu,Fu-Tong Liu,Nobuyuki Takakura Nature communications 12 1 2118 2021/04/09
- Cellular heterogeneity and stem cells of vascular endothelial cells in blood vessel formation and homeostasis: Insights from single-cell RNA sequencing. Taku Wakabayashi,Hisamichi Naito Frontiers in cell and developmental biology 11 1146399 2023
- Identification of CD157-Positive Vascular Endothelial Stem Cells in Mouse Retinal and Choroidal Vessels: Fluorescence-Activated Cell Sorting Analysis. Taku Wakabayashi,Hisamichi Naito,Tomohiro Iba,Kohji Nishida,Nobuyuki Takakura Investigative ophthalmology & visual science 63 4 5 2022/04/01
- Single-cell sequencing reveals the existence of fetal vascular endothelial stem cell-like cells in mouse liver Fitriana N. Rahmawati,Tomohiro Iba,Hisamichi Naito,Shota Shimizu,Hirotaka Konishi,Weizhen Jia,Nobuyuki Takakura Stem Cell Research & Therapy 14 1 2023/08/30
- Collagen XVII regulates tumor growth in pancreatic cancer through interaction with the tumor microenvironment. Ryosuke Kashiwagi,Ryo Funayama,Shuichi Aoki,Aya Matsui,Sebastian Klein,Yukihiro Sato,Tsubasa Suzuki,Keigo Murakami,Koetsu Inoue,Masahiro Iseki,Kunihiro Masuda,Masamichi Mizuma,Hisamichi Naito,Dan G Duda,Michiaki Unno,Keiko Nakayama Cancer science 2023/09/08
- Viral uptake and pathophysiology of the lung endothelial cells in age-associated severe SARS-CoV-2 infection models. Takuya Tsumita,Ryo Takeda,Nako Maishi,Yasuhiro Hida,Michihito Sasaki,Yasuko Orba,Akihiko Sato,Shinsuke Toba,Wataru Ito,Takahito Teshirogi,Yuya Sakurai,Tomohiro Iba,Hisamichi Naito,Hitoshi Ando,Haruhisa Watanabe,Amane Mizuno,Toshiki Nakanishi,Aya Matsuda,Ren Zixiao,Ji-Won Lee,Tadahiro Iimura,Hirofumi Sawa,Kyoko Hida Aging cell e14050 2023/12/14
- Diabetes accelerates steatohepatitis in mice: liver pathology and single-cell gene expression signatures Tuerdiguli Abuduyimiti,Hisanori Goto,Kumi Kimura,Yu Oshima,Ryota Tanida,Kyoko Kamoshita,Nontaphat Leerach,Halimulati Abuduwaili,Hein Ko Oo,Qifang Li,Cynthia M. Galicia-Medina,Hiroaki Takayama,Kiyo-aki Ishii,Yujiro Nakano,Yumie Takeshita,Tomohiro Iba,Hisamichi Naito,Masao Honda,Kenichi Harada,Yasuhiko Yamamoto,Toshinari Takamura The American Journal of Pathology 2024/02
Conference Presentations
- The role of endothelial stem cell in vascular regeneration(2019/05/25)
- Mechanism of Ischemia Induced Angiogenesis Defined at Single Cell Resolution(2022/03/28)
- Endothelial side population cells contribute to tumor angiogenesis(conference：19th International Vascular Biology Meeting)(2016/11)
- Identification of Vascular Endothelial Side Population cells and their role in Angiogenesis(conference：The 11th Japan-Korea Joint Symposium on Vascular Biology)(2013/08/23)
- Vascular Endothelial Cell Heterogeneity and Mechanism of Vascular Formation(2023/03/15)
- Role of vascular resident endothelial stem/progenitor cells in pathophysiological angiogenesis.(conference：The 13th Japan-Korea Joint Symposium on Vascular Biology)(2015/10/17)
- The role of vascular endothelial stem cells and their characterization at single cell resolution(conference：Asia-Australia Vascular Biology Meeting (AAVBM) 2022)(2022/01/21)
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「腫瘍血管における新しい内皮細胞の探索と新規血管阻害療法の開発」(2019-2020)
○「血管内皮細胞の多様性の解明と疾患治療への応用」(2020-2023)