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Researcher Information

last modified:2024/03/22

Associate Professor KUDO, Nobuaki


Faculty, Affiliation

Frontier Science and Social Co-creation Initiative

College and School Educational Field


Academic Background

【Academic background(Doctoral/Master's Degree)】
University of Tokyo Doctor Graduate School of Agriculture & Life Sciences Department of Biotechnology 199903 Completed
University of Tokyo Doctor Graduate School of Pharmaceutical Sciences Department of Pharmaceutical Biology 199603 Unfinished course
University of Tokyo Master Graduate School of Agriculture Department of Biotechnology 199403 Completed
【Academic background(Bachelor's Degree)】
University of Tokyo Department of Agricultural Chemistry 199203


Kanazawa University Frontier Science and Social Co-creation Initiative Associate Professor (2022-)
Tsukuba University International Institute for Integrative Sleep Medicine (WPI-IIIS) URA (2020-2022)
JAPAN Creative Platform Group Co., Ltd Office of Strategic Development Academic Advisor (2019-2019)
Imperial College London Institute of Reproductive and Developmental Biology, Faculty of Medicine Head of Research Group, Lecturer (2007-2016)
Research Institute of Molecular Pathology (IMP) Kim Nasmyth Group Postdoctoral Research Fellow (2001-2007)

Year & Month of Birth


Academic Society

Preimplantation Genetic Diagnosis International Society (PGDIS)


○The Young Investigator Award of the Japanese Association for Molecular Target Therapy of Cancer (2000)
○The 17th Inoue Research Award for Young Scientists (2000)


Applied molecular and cellular biology、Genetics/Chromosome dynamics、Chemical biology

Speciality Keywords

Chromosomes, Meiosis, Oocyte ageing

Research Themes



  •  De novo DNA methylation drives 5hmC accumulation in mouse zygotes. Amouroux D, Nashun B, Shirane K, Nakagawa S, Hill PW, D’Souza Z, Nakayama M, Matsuda M, Turp A, Ndjetehe E, Encheva V, Kudo NR, Koseki H, Sasaki H, Hajkova P. Nat Cell Biol. 18 2 225 2016
  •  Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II. Adhikari D, Diril MK, Busayavalasa K, Risal S, Nakagawa S, Lindkvist R, Shen Y, Coppola V, Tessarollo L, Kudo NR, Kaldis P, Liu K. J Cell Biol. 206 7 843 2014
  •  Rec8-containing cohesin maintains bivalents without turnover during the growing phase of mouse oocytes. Tachibana-Konwalski K, Godwin J, van der Weyden L, Champion L, Kudo NR, Adams DJ, Nasmyth K. Genes Dev. 24 22 2505 2010
  •  Resolution of chiasmata in oocytes requires separase-mediated proteolysis. Kudo NR, Wassmann K, Anger M, Schuh M, Wirth KG, Xu H, Helmhart W, Kudo H, Mckay M, Maro B, Ellenberg J, de Boer P, Nasmyth K. Cell 126 1 135 2006
  •  Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region. Kudo N, Matsumori N, Taoka H, Fujiwara D, Schreiner EP, Wolff B, Yoshida M, Horinouchi S. Proc Natl Acad Sci U S A. 96 16 9112 1999

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  •  Increased expression of cytotoxic T-lymphocyte-associated protein 4 by T cells, induced by B7 in sera, reduces adaptive immunity in patients with acute liver failure. Khamri W, Abeles RD, Hou TZ, Anderson AE, El-Masry A, Triantafyllou E, Bernsmeier C, Larsen FS, Singanayagam A, Kudo N, Possamai LA, Lebosse F, Auzinger G, Bernal W, Willars C, Weston CJ, Lombardi G, Wendon J, Thursz M, Antoniades CG. Gastroenterology 153 1 263 2017
  •  Dual-mode regulation of the APC/C by CDK1 and MAPK controls meiosis I progression and fidelity. Nabti I, Marangos P, Bormann J, Kudo NR, Carroll J. J Cell Biol. 204 6 891 2014
  •  Cohesin loading factor Nipbl localizes to chromosome axes during mammalian meiotic prophase. Kuleszewicz K, Fu X, Kudo NR*. Cell Div. 8 1 12 2013
  •  Role of cleavage by separase of the Rec8 kleisin subunit of cohesin in mammalian meiosis I. Kudo NR*, Anger M, Peters AH, Stemmann O, Theussl HC, Helmhart W, Kudo H, Heyting C, Nasmyth K*. J Cell Sci. 122 15 2686 2009
  •  Regulation of APC/C activity in oocytes by a Bub1-dependent spindle assembly checkpoint. McGuinness BE, Anger M, Kouznetsova A, Gil-Bernabe A, Helmhart W, Kudo NR, Wuensche A, Taylor S, Hoog C, Novak B, Nasmyth K. Curr Biol. 19 5 369 2009
  •  Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression. Wirth KG, Wutz G, Kudo NR, Desdouets C, Zetterberg A, Taghybeeglu S, Seznec J, Ducos GM, Ricci R, Firnberg N, Peters JM, Nasmyth K. J Cell Biol. 172 6 847 2006
  •  Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells. McGuinness BE, Hirota T, Kudo NR, Peters JM, Nasmyth K. PloS Biol. 3 3 e86 2005
  •  Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation. Wirth KG, Ricci R, Gimenez-Abian JF, Taghybeeglu S, Kudo NR, Jochum W, Vasseur-Cognet M, Nasmyth K. Genes Dev. 18 1 88 2004
  •  New Rev-transport inhibitor with anti-HIV activity from Valerianae Radix. Murakami N, Ye Y, Kawanishi M, Aoki S, Kudo N, Yoshida M, Nakayama EE, Shioda T, Kobayashi M. Bioorg Med Chem Lett. 12 20 2807 2002
  •  Developmentally regulated activity of CRM1/XPO1 during early Xenopus embryogenesis. Callanan M, Kudo N, Gout S, Brocard M, Yoshida M, Dimitrov S, Khochbin S. J Cell Sci. 113 3 451 2000
  •  A nuclear export signal in the N-terminal regulatory domain of IkappaBalpha controls cytoplasmic localization of inactive NF-kappaB/IkappaBalpha complexes. Huang TT, Kudo N, Yoshida M, Miyamoto S. Proc Natl Acad Sci U S A. 97 3 1014 2000
  •  Oxidative stress abolishes leptomycin B-sensitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element. Hoshino H, Kobayashi A, Yoshida M, Kudo N, Oyake T, Motohashi H, Hayashi N, Yamamoto M, Igarashi K. J Biol Chem. 275 20 15370 2000
  •  A novel nuclear export signal sensitive to oxidative stress in the fission yeast transcription factor Pap1. Kudo N, Taoka H, Toda T, Yoshida M, Horinouchi S. J Biol Chem. 274 21 15151 1999
  •  Identification of a novel nuclear export signal sensitive to oxidative stress in yeast AP-1-like transcription factor. Kudo N, Taoka H, Yoshida M, Horinouchi S. Ann N Y Acad Sci. 886 204 1999
  •  Leptomycin: a specific inhibitor of protein nuclear export Yoshida M, Kudo N, Horinouchi S. Tanpakushitsu Kakusan Koso. 44 9 1379 1999
  •  Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Kudo N, Wolff B, Sekimoto T, Schreiner EP, Yoneda Y, Yanagida M, Horinouchi S, Yoshida M.  Exp Cell Res. 242 2 540 1998
  •  Leptomycin, an antifungal and antitumor Streptomyces metabolite, is a novel chemical probe for eukaryotic nucleo-cytoplasmic transport. Yoshida M, Kudo N, Taoka H, Akakura S, Horinouchi S. Actinomycetol. 2 2 120 1998
  •  Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins. Kudo N, Khochbin S, Nishi K, Kitano K, Yanagida M, Yoshida M, Horinouchi S.  J Biol Chem. 272 47 29742 1997
  •  Cloning and characterization of a gene involved in aerial mycelium formation in Streptomyces griseus. Kudo N, Kimura M, Beppu T, Horinouchi S. J Bacteriol.  177 22 6401 1995
  •  Plasmid-mediated gene disruption in Streptomyces griseus. Kudo N, Ueda K, Ikeda H, Omura H, Beppu T, Horinouchi S. Actinomycetol. 8 1 17 1994

Conference Presentations

  • Mouse meiotic chromosome segregation: High incidences of human oocyte aneuploidy.(conference:The 18th World Congress on Controversies in Obstetrics, Gynaecology & Infertility (COGI))(2013/10)
  • The anaphase-promoting complex (APC/C) is required for primordial follicle survival in mice.(conference:EMBO Workshop for Oocyte Maturation and Fertilization.)(2013/06)
  • Why human eggs are so often aneuploid? A novel hypothesis from chromosome cohesion.(conference:The 11th International Conference on Preimplantation Genetic Diagnosis (PGDIS))(2012/05)
  • Maintenance of chromosome cohesion during meiotic prophase in mouse oocytes.(conference:EMBO Conference on Meiosis.)(2011/09)
  • Maintenance of meiotic prophase in mouse oocytes.(conference:The Meiosis Gordon Conference)(2010/06)


Arts and Fieldwork


Theme to the desired joint research

Grant-in-Aid for Scientific Research

Competitive research funding,Contribution

○Chromosome cohesion during protracted meiotic arrest in oocytes New Investigator Research Grant Medical Research Council (MRC)(2009-2013)
○Maintenance of chromosome cohesion during protracted meiotic arrest in mammalian oocytes; an essential mechanism for developing eggs with correct numbers of chromosomes Research Grant The Royal Society(2009-2010)
○Aneuploidy in early embryos Research Grant Genesis Research Trust / Institute of Obstetrics and Gynaecology Trust(2008-2014)

Collaborative research,Consignment study

Classes (Bachelors)

Classes (Graduate Schools)

International Project

International Students

Lecture themes

Others (Social Activities)

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