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Researcher Information

last modified:2017/06/08

Professor ANDO Toshio

Mail Laboratory Website
Laboratory Website

Faculty, Affiliation

Bio-AFM Frontier Research Center
Head of Imaging Research Division, Bio-AFM Frontier Research Center

College and School Educational Field

Division of Mathematical and Physical Science, Graduate School of Natural Science and Technology
Division of Mathematical and Physical Sciences, Graduate School of Natural Science and Technology
School of Mathematics and Physics, College of Science and Engineering

Laboratory

Biophysics Lab. TEL:076-264-5663 FAX:076-264-5739

Academic Background

【Academic background(Doctoral/Master's Degree)】
Waseda University Doctor Physics and Applied Physics 198003 Completed
【Academic background(Bachelor's Degree)】
Waseda University 197403
【Degree】
Doctor of Science

Career

Kanazawa University Natural Science & Technology(2003/04/01-)
Kanazawa University Faculty of Science(1996/07/01-2003/03/31)
Kanazawa University Faculty of Science(1992/08/01-1996/06/30)
Kanazawa University Faculty of Science(1986/04/01-1992/07/31)
University of California, San Francisco Cardiovascular Research Institute Assistant Research Biophysicist(1983/01/01-1986/03/31)
UC San Francisco, CVRI, Posdoc(1980/04/01-1982/12/31)

Year & Month of Birth

1951/03

Academic Society


American Physical Society

Jananese Socisty of Applied Physics
The Surface Science Society of Japan
Japanese Society of Microscopy

Award

○Harushige Inoue Prize(2016/07/20)
○Doctor Honoris Causa (Aix-Marseille Univ.)(2014/11/18)
○Shimadzu Prize(2014/02/17)
○Distinguished Contribution Award for Research and Education, Kanazawa University (2013/11/02)
○Chairman's prize of the Japanese Association of Invention (2013/06/18)
○Science & Technology Award of the Minister of Education, Culture, Sports, Science and Tech(2013/04/16)
○Kanazawa City Culture Prize(2012/11/03)
○University of Pennsylvania NBIC Research Excellence Award in Nanotechnology (2012/10/24)
○Yamazaki-Teiichi Prize (Foundation for Promotion of Material Science and Technology of Jap(2010/09/16)
○Hokkoku Calture Prize(2005/11/03)
○Hokkoku Calture Prize(2005/11/03)
○Award of the Japanese Society of Microscopy (2011/05/17)
○Award of the Surface Science Society of Japan (2010/05/22)
○Sakaki Prize (JSPS)(2008/09/16)
○Nanoprobe Technology Prize(2004/07/21)
○Best Paper Award of the Japan Society of Applied Physics(2007/09/07)
○2007 Distinguished Service Award of the President of Science Council of Japan(2007/06/16)
○Nikkei BP Technology Prize(2003/04/04)

Specialities

Nanomaterials chemistry、Biophysics

Speciality Keywords

motor proteins, single-molecule analysis, Atomic Force Microscope

Research Themes

Study on Motor Proteins

Study on Motor Proteins Motor proteins cordinate cell motility. We study them to understand their functional mechanism. For this purpose, we have been developing various techniques including high-speed AFM and fluorescence microscopy techniques. The left movie of walking myosin V comes from our paper published in Nature (Article) on November 4, 2010. Please look at other movies at our lab website.

Development and Biological Application of High-speed Atomic Force Microscopy

Development and Biological Application of High-speed Atomic Force Microscopy We have developed high-speed AFM capable of simultaneously recording the structure and dynamics of biological molecules at high spatiotemporal resolution. The capacity has now nearly reached the theoretical upper limit. Using this state-of-the-art microscopy, we are now imaging various functioning biomolecules in action to understand their functional mechanisms. The left images show dynamic structural changes of bacteriorhodopsin in response to light illumination (a, under dark; b, under light illumination).

Awards

Awards We have been awarded honorable prizes for the achievement of developing high-speed atomic force microscopy and its biological applications. This is the result of efforts by colleagues and many students in my lab.
2014.11.18 Doctor Honoris Causa from the Aix-Marseille Univ.
2014.2.17 Shimadzu Prize (Shimadzu Foundation for Promotion of Science & Technology)
2013.11.2 Distinguished Contribution Award for Research and Education, Kanazawa Univ.
2013.6.18 Chairman's prize of the Japanese Association of Invention
2013.4.16 Science & Technology Award of the Minister of Education, Culture, Sports, Science and Technology
2012.11.3 Kanazawa City Culture Prize
2012.10.24 Univ. of Pennsylvania NBIC Award for Research Excellence in Nanotechnology
2011.5.17 Best Paper Award of the Japanese Society of Microscopy
2010.9.16 Yamazaki-Teiichi Prize (Foundation for Promotion of Material Science and Technology of Japan)
2010.5.22 Award of the Surface Science Society of Japan
2008.9.16 Sakaki Prize (JSPS)
2007.9.4 Best Paper Award of the Japan Society of Applied Physics
2007.6.16 Distinguished Service Award of the President of Science Council of Japan
2005.11.3 Hokkoku Culture Prize
2004.7.21 Nanoprobe Technology Prize (JSPS)
2003.4.4 Nikkei BP Technology Prize

   

Books

  •  Takayuki Uchihashi, Noriyuki Kodera, Toshio Ando  Noncontact Atomic Force Microscopy Vol.3 (Seizo Moprita, Franz J. Giessibl, Ernst Meyer, Roland Wiesendanger, Eds) Springer 2015
  •  Takayuki Uchihahsi, Noriyuki Kodera, Toshio Ando Atomic Force Microscopy in Nanobiology (Kunio Takeyasu Ed.)  Pan Stanford Publishing 2014
  •  Toshio Ando, Takayuki Uchihashi  Nanoscale Liquid Interfaces: Wetting, Patterning, and Force Microscopy at the Molecular Scale (Thierry ONDARÇUHU, Jean-Pierre Aimé Ed.) Pan Stanford Publishing 2013
  •  Takayuki Uchihashi, Noriyuki Kodera, Toshio Ando Single-molecule Studies of Proteins. Biophysics for the Life Sciences Vol 2 (Andres Oberhauser, ed)  Springer 2013
  •  Noriyuki Kodera, Toshio Ando Springer series Methods in Molecular Biology, vol. 897, part 1 "Experimental Tools for the Intrinsically Disordered Protein Analysis Springer 2012/01

show all

  •  Techniques for developing high-speed AFM Springer 2011/07
  •  T. Ando Single Molecule Dynamics in Life Science Wiley-VCH 2008/08
  •  T. Ando, T. Uchihasi High-speed atomic force microscopy Springer-Verlarg  2009/09
  •  T. Ando Roadmap of Scanning Probe Microscopy Springer-Verlag  2006/06
  •  T. Uchihashi, T. Ando High-speed atomic force microscopy for dynamic biological imaging Pan Stanford Publishing Pte. Ltd. 2011/07
  •  Single-molecule Biology (Yoshie Harada & Shin'ichi Ishiwata Ed) 2014/09

Papers

  •  Go to the lab website for all publications: http://www.s.kanazawa-u.ac.jp/phys/biophys/recent_publication.htm Toshio Ando
  •  Chaperonin GroEL-GroES functions as both alternating and non-alternating engines D. Yamamoto and T. Ando J. Mol. Biol. 428 3090-3101  2016
  •  High-speed atomic force microscopy reveals strongly polarized movement of clostridial collagenase along collagen fibrils T. Watanabe-Nakayama, M. Itami, N. Kodera, T. Ando and H. Konno Scientific Reports 6 28975 2016
  •  The Intrinsically Disordered Protein Atg13 Mediates Supramolecular Assembly of Autophagy Initiation Complexes Hayashi Yamamoto, Yuko Fujioka, Sho W. Suzuki, Daisuke Noshiro, Hironori Suzuki, Chika Kondo-Kakuta, Yayoi Kimura, Hisashi Hirano, Toshio Ando, Nobuo N. Noda, Yoshinori Ohsumi Dev. Cell  38 86-99 2016
  •  Functional extension of high-speed atomic force microscopy T. Uchihashi, H. Watanabe, S. Fukuda, M. Shibata and T. Ando Ultramicroscopy 160 182-196  2016

show all

  •  Two-ball structure of the flagellar hook-length control protein FliK as revealed by high-speed atomic force microscopy N. Kodera, K. Uchida, T. Ando, and S. Aizawa J. Mol. Biol.  427 406-414  2015
  •  Method of mechanical holding of cantilever chip for tip-scan high-speed atomic force microscopy Shingo Fukuda, Takayuki Uchihashi, Toshio Ando Rev. Sci. Instrum.  86 063703 2015
  •  Cofilin-induced unidirectional cooperative conformational changes in actin filaments revealed by high-speed AFM Kien Xuan Ngo, Noriyuki Kodera, Eisaku Katayama, Toshio Ando and Taro Q.P. Uyeda e-Life  4 e04806 2015
  •  Potential pre-pore trimer formation by the Bacillus thuringiensis mosquito-specific toxin: Molecular insights into a critical prerequisite of membrane-bound monomers Wilaiwan Sriwimol, Aratee Aroonkesorn, Somsri Sakdee, Chalermpol Kanchanawarin, Takayuki Uchihashi, Toshio Ando and Chanan Angsuthanasombat  J. Biol. Chem. 290 34 20793-20803  2015
  •  CYK4 Promotes Antiparallel Microtubule Bundling by Optimizing MKLP1 Neck Conformation T. Davies, N. Kodera, G. S. Kaminski Schierle, E. Rees, M. Erdelyi, C. F. Kaminski, T. Ando, M. Mishima  PloS Biol. 13 4 e1002121 (26 pp) 2015
  •  Long-tip high-speed atomic force microscopy for nanometer-scale imaging in live cells M. Shibata, T. Uchihashi, T. Ando and R. Yasuda Scientific Reports  5 8724 (7 pp) 2015
  •  Probing structural dynamics of an artificial protein cage using high-speed atomic force microscopy M. Imamura, T. Uchihashi, T. Ando, A. Leifert, U. Simon, A. D. Malay and J. G. Heddle Nano Lett.  15 2 1331-1335 2015
  •  IgGs are made for walking on bacterial and viral surfaces J. Preiner, N. Kodera, J. Tang, A. Ebner, M. Brameshuber, D. Blaas, N. Gelbmann, H. Gruber, T. Ando, and P. Hinterdorfer Nature Communications  5 4394 (8 pp) 2014
  •  Multiple Interactions of the Intrinsically Disordered Region between the N-terminal Helicase and C-terminal Nuclease Domains of the Archaeal Hef Protein  S. Ishino, T. Yamagami, M. Kitamura, N. Kodera, T. Mori, S. Sugiyama, T. Ando, N. Goda, T. Tenno, H. Hiroaki, and Y. Ishino J. Biol. Chem. 289 21627-21639  2014
  •  High-speed AFM imaging Toshio Ando Curr. Opin. Struct. Biol.  28 63-68 2014
  •  The path to visualization of walking myosin V by high-speed atomic force microscopy N. Kodera and T. Ando Biophys. Rev. 6 237-260  2014
  •  Single-molecule imaging analysis of elementary reaction steps of Trichoderma Reesei cellobiohydrolase I (Cel7A) hydrolyzing crystalline cell Y. Shibafuji, A. Nakamura, T. Uchihashi, N. Sugimoto, S. Fukuda, H. Watanabe, M. Samejima, T. Ando, H. Noji, A. Koivula, K. Igarashi, and R. Iino J. Biol. Chem. 289 14056-14065  2014
  •  Filming biomolecular processes by high-speed atomic force microscopy T. Ando, T. Uchihashi, and S. Scheuring Chem. Rev. 114 6 3120-3188  2014
  •  Trade-off between processivity and hydrolytic velocity of cellobiohydrolases at the surface of crystalline cellulose A. Nakamura, H. Watanabe, T. Ishida, T. Uchihashi, M. Wada, T. Ando, K. Igarashi, and M. Samejima J. Am. Chem. Soc.  136 4584-4592 2014
  •  Two-way traffic of glycoside hydrolase family 18 processive chitinases on crystalline chitin K. Igarashi, T. Uchihashi, T. Uchiyama, H. Sugimoto, M. Wada, K. Suzuki, S. Sakuda, T. Ando, T. Watanabe, and M. Samejima Nature Communications 5 3975 2014
  •  High-speed atomic force microscopic observation of ATP-dependent rotation of the AAA+ chaperone p97 Kentaro Noi, Daisuke Yamamoto, Shingo Nishikori, Ken-ichi Arita-Morioka, Toshio Ando and Teru Ogura Structure 21 1992-2002 2013
  •  High-speed atomic force microscopy of protein dynamics: myosin on actin and rotary enzyme F1-ATPase Toshio Ando Microscopy & Analysis  27 3 10-13 2013
  •  Real-Time Visualization of Assembling of a Sphingomyelin-Specific Toxin Neval Yilmaz, Taro Yamada, Peter Greimel, Takayuki Uchihashi, Toshio Ando, and Toshihide Kobayashi Biophys. J.  105 1397-1405 2013
  •  High-speed AFM and applications to biomolecular systems T. Ando, T. Uchihashi, and N. Kodera Annual Review of Biophysics 42 393-414  2013
  •  Role of trimer-trimer interaction of bacteriorhodopsin studied by optical spectroscopy and high-speed atomic force microscopy H. Yamashita, K. Inoue, M. Shibata, T. Uchihashi, J. Sasaki, H. Kandori, and T. Ando J. Struct. Biol.  184 2-11 2013
  •  Wide-area scanner for high-speed atomic force microscopy H. Watanabe, T. Uchihashi, T. Kobashi, M. Shibata, J. Nishiyama, R. Yasuda, and T. Ando Review of Scientific Instruments 84 5 053702 2013
  •  Molecular Machines directly observed by high-speed atomic force microscopy FEBS LETTERS 587 8 997-1007 2013
  •  High-speed atomic force microscopy Microscopy 62 1 81-93  2013
  •  Phosphorylation-Coupled Intramolecular Dynamics of Unstructured Regions in Chromatin Remodeler FACT M. Hashimoto, N. Kodera, Y. Tsunaka, M. Oda, M. Tanimoto, T. Ando, K. Morikawa, and S. Tate BIOPHYSICAL JOURNAL 104 10 2222-2234  2013
  •  High-speed atomic force microscope combined with single-molecule fluorescence microscope S. Fukuda, T. Uchihashi, R. Iino, Y. Okazaki, M. Yoshida, K. Igarashi REVIEW OF SCIENTIFIC INSTRUMENTS 84 7 073706  2013
  •  Guide to video recording of structure dynamics and dynamic processes of proteins by high-speed atomic force microscopy T. Uchihashi, N. Kodera, and T. Ando Nature Protocols 7 6 1193-1206  2012
  •  Single molecule imaging on living bacterial cell surface by high-speed AFM H. Yamashita, A. Taoka, T. Uchihashi, T. Asano, T. Ando, and Y. Fukumori JOURNAL OF MOLECULAR BIOLOGY 422 2 300-309 2012
  •  High-speed atomic force microscopy T. Ando, T. Uchihashi, and N. Kodera JAPANESE JOURNAL OF APPLIED PHYSICS 51 08KA02 2012
  •  High-speed atomic force microscopy coming of age NANOTECHNOLOGY 23 6 062001 2012
  •  Visualization of cellobiohydrolase I from Trichoderma reesei moving on crystalline cellulose using high-speed atomic force microscopy K. Igarashi, T. Uchihashi, A. Koivula, M. Wada, S. Kimura, M. Penttilä, T. Ando, and M. Samejima METHODS IN ENZYMOLOGY 510 169-182  2012
  •  High-speed atomic force microscopy reveals rotary catalysis of rotorless F1-ATPase T. Uchihashi, R. Iino, T. Ando, and H. Noji SCIENCE 333 6043 755-758 2011
  •  Dynamics of nucleosomes assessed with time-lapse high speed atomic force microscopy A. Miyagi, T. Ando and Y. L. Lyubchenko Biochemistry 50 7901-7908  2011
  •  Self-assembly properties and dynamic of synthetic proteo-nucleic building blocks in solution and on surfaces  A. Laisne, M. Ewald, T. Ando, E. Lesniewska, D. Pompon Bioconjugate Chem.  22 1824-1834  2011
  •  High-speed atomic force microscopy and biomolecular processes T. Uchihashi and T. Ando Methods Mol. Biol. 736 285-300 2011
  •  Structural changes in bacteriorhodopsin in response to alternate illumination observed by high-speed atomic force microscopy M. Shibata, T. Uchihashi, H. Yamashita, H. Kandori, and T. Ando ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 50 4410 –4413  2011
  •  Traffic jams reduce hydrolytic efficiency of cellulase on cellulose surface K. Igarashi, T. Uchihashi, A. Koivula, M. Wada, S. Kimura, T. Okamoto, M. Penttilä, T. Ando, and M. Samejima SCIENCE 333 1279-1282  2011
  •  Imaging of nucleic acids with atomic force microscopy Y. L. Lyubchenko, L. S. Shlyakhtenko, and T. Ando METHODS 54 274-283  2011
  •  Direct Observation of Surfactant Aggregate Behavior on a Mica Surface using High-Speed Atomic Force Microscopy S. Inoue, T. Uchihashi, D. Yamamoto, and T. Ando CHEMICAL COMMUNICATIONS 47 4974–4976  2011
  •  Video imaging of walking myosin V by high-speed atomic force microscopy N. Kodera, D. Yamamoto, R. Ishikawa, and T. Ando NATURE  468 7320 72-76  2010
  •  High-speed atomic force microscopy shows dynamic molecular processes in photo-activated bacteriorhodopsin M. Shibata, H. Yamashita, T. Uchihashi, H. Kandori, and T. Ando Nature Nanotechnology 5 208-212  2010
  •  Deciphering the structure, growth and assembly of amyloid-like fibrils using high-speed atomic force microscopy P.-E. Milhiet, D. Yamamoto, O. Berthoumieu, P. Dosset, Ch. Le Grimellec, J.-M. Verdier, S. Marchal, and T. Ando PLos One 5 11 e13240 (8 pp) 2010
  •  High-speed atomic force microscopy techniques for observing dynamic biomolecular processes D. Yamamoto, T. Uchihashi, N. Kodera, H. Yamashita, S. Nishikori, T. Ogura, M. Shibata, and T. Ando METHODS IN ENZYMOLOGY 475 Part B 541-56 2010
  •  Visualization and structural analysis of the bacterial magnetic organelle magnetosome using atomic force microscopy D. Yamamoto, A. Taoka, T. Uchihashi, H. Sasaki, H. Watanabe, T. Ando, and Y. Fukumori PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME 107 20 9382-9387  2010
  •  AAA+ chaperone ClpX regurates dynamics of prokaryotic cytoskeletal protein FtsZ S. Sugimoto, K. Yamanaka, S. Nishikori, A. Miyagi, T. Ando, and T. Ogura JOURNAL OF BIOLOGICAL CHEMISTRY 285 9 6648-6657 2010
  •  Surface topography of membrane domains M.-C. Giocondi, D. Yamamoto, E. Lesniewska, P.-E. Milhiet, T. Ando, and Ch. Le Grimellec BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1978 703-718  2010
  •  High-resolution high-speed contact mode atomic force microscopy movies of purple membrane I. Casuso, N. Kodera, C. Le Grimellec, T. Ando, and S. Scheuring BIOPHYSICAL JOURNAL 97 5 1354-1361  2009
  •  Dynamics of bacteriorhodopsin 2D crystal observed by high-speed atomic force microscopy. H. Yamashita, K. Voitchovsky, T. Uchihashi, S. Antoranz Contera, J. F. Ryan, and T. Ando JOURNAL OF STRUCTURAL BIOLOGY 167 2 153-158 2009
  •  Single-molecule imaging of a micro-Brownian motion of a chiral helical π-conjugated polymer as a molecular spring driven by thermal fluctuations K. Shinohara, N. Kodera, and T. Ando CHEMISTRY LETTERS 38 7 690-691  2009
  •  Streptavidin 2D crystal substrates for visualizing biomolecular processes by atomic force microscopy D. Yamamoto, N. Nagura, S. Omote, M. Taniguchi, and T. Ando BIOPHYSICAL JOURNAL 97 8 2358–2367  2009
  •  High-speed atomic force microscopy for nano-visualization of dynamic biomolecular processes T. Ando, T. Uchihashi, and T. Fukuma PROGRESS IN SURFACE SCIENCE 83 337-437  2008
  •  Visualization of intrinsically disordered regions of proteins by high-speed atomic force microscopy. A. Miyagi, Y. Tsunaka, T. Uchihashi, K. Mayanagi, S. Hirose, K. Morikawa, T. Ando CHEMPHYSCHEM 9 13 1859-1866 2008
  •  Anisotropic diffusion of point defects in two-dimensional crystal of streptavidin observed by high-speed atomic force microscopy. D. Yamamoto, T. Uchihashi, N. Kodera, T. Ando NANOTECHNOLOGY 19 384009-384017 2008
  •  High-speed AFM and nano-visualization of biomolecular processes T. Ando, T. Uchihashi, N. Kodera, D. Yamamoto, M. Taniguchi, A. Miyagi, and H. Yamashita PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 456 211-225  2008
  •  High resonance frequency force microscope scanner using inertia balance support. T. Fukuma, Y. Okazaki, N. Kodera, T. Uchihahsi, T. Ando APPLIED PHYSICS LETTERS 92  , 243119-243121 2008
  •  Tip-sample distance control using photo-thermal actuation of a small cantilever for high-speed atomic force microscopy. H. Yamashita, T. Uchihashi, N. Kodera, A. Miyagi, D. Yamamoto, T. Ando REVIEW OF SCIENTIFIC INSTRUMENTS 78  - 83702-83706 2007
  •  Fabrication of 3D micro-cantilevers based on MBE-grown strained semiconductor layers H. Iwase, H. Choi, M. Akabori, T. Suzuki, S. Yamada, D. Yamamoto, T. Ando Physica E: Low-dimensional Systems and Nanostructures  40 6 2210-2213  2008
  •  Control techniques in high-speed atomic force microscopy Toshio Ando Proceedings of the American Control Conference art. no. 4586984 3194-3200  2008
  •  High-speed atomic force microscopy for observing dynamic biomolecular processes T. Ando, T. Uchihashi, N. Kodera, D. Yamamoto, M. Taniguchi, A. Miyagi, H. Yamashita J. Mol. Recognit. 20 448-458  2007
  •  Tip-sample distance control using photo-thermal actuation of a small cantilever for high-speed atomic force microscopy H. Yamashita, T. Uchihashi, N. Kodera, A. Miyagi, D. Yamamoto, T. Ando Rev. Sci. Instrum. 78 083702 (5 pp)  2007
  •  Single Molecular Imaging of a micro-Brownian Motion and a Bond Scission of a Supramolecular Chiral pai-conjugated. K. Shinohara, N. Kodera, T. Ando CHEMISTRY LETTERS 36 1378-1379 2007
  •  Japan AFM roadmap 2006 S. Morira, H. Yamada, T. Ando NANOTECHNOLOGY 18 x 084001-084010 2007
  •  A dynamic PID controller for high-speed atomic force microscopy N. Kodera, M. Sakashita, and T. Ando REVIEW OF SCIENTIFIC INSTRUMENTS 77 8 083704-7 2006
  •  Identification of the specific IQ motif of myosin V from which calmodulin dissociates in the presence of Ca2+. H. Koide, T. Kinoshita, Y. Tanaka, S. Tanaka, N. Nagura, G. Meyer zu Hoerste, A. Miyagi BIOCHEMISTRY 45 38 11598-11604 2006
  •  Fast phase imaging in liquids using a rapid scan atomic force microscope T. Uchihashi, H. Yamashita, T. Ando APPLIED PHYSICS LETTERS 89 21 213112-3 2006
  •  Feed-forward compensation for high-speed atomic force microscopy imaging of biomolecules. T. Uchihashi, N. KOdera, H. Ito, H. Yamashita, T. Ando JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REV 45 3B 1904-1908 2006
  •  Fast-scaaning atomic foece microscopy reveals the ATP/ADP-dependent conformational changes of GroEL. M. Yokokawa, S.H. Yoshimura, Y. Naito, T. Ando, A. Yagi, S. Sakai, K. Takeyasu EMBO JOURNAL 25 x 4567-4576 2006
  •  High-speed atomic force microscopy for studying dynamic behavior of protein molecules at work. T. Ando, T. Uchihashi, N. Kodera, A. Miyagi, R. Nakakita, H. Yamashita, M. Sakashita JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REV 45 3B 1897-1903 2006
  •  Fast-scanning atomic force microscopy reveals the molecular mechanism of DNA cleavage by ApaI endonuclease. M. Yokokawa, S.H. Yoshimura, Y. Naito, T. Ando, A. Yagi, N. Sakai, K. Takeyasu IEE Proc. Nanobiotechnology 153 4 60-66 2006
  •  Active damping of the scanner for high-speed atomic force microscopy. REVIEW OF SCIENTIFIC INSTRUMENTS 76 5 053708 2005
  •  High-speed AFM for studying the dynamic behavior of protein molecules at work T. Ando, T. Uchihashi, N. Kodera, A. Miyagi, R. Nakakita, H. Yamashita, K. Matada e-J. Surf. Sci. Nanotechnol.  3 384-392 2005
  •  Polarized Actin Bundles Formed by Human fascin-1: Their Sliding and Disassembly on Myosin II and Myosin V in vitro. R. Ishikawa, T. Sakamoto, T. Ando JOURNAL OF NEUROCHEMISTRY 87 676-685 2003
  •  High-resolution Imaging of Myosin Motor in Action by a High-speed Atomic Force Microscope. N. Kodera, T. Ando ADVANCES IN PROTEIN CHEMISTRY 538 119-127 2003
  •  A high-speed Atomic force microscope for studying biological macromolecules in action. CHEMPHYSCHEM 4 1196-1202 2003
  •  A high-speed atomic force microscope for studying biological macromolecules in action JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REV 41 7B 4851-4856 2002
  •  A high-speed atomic force microscope for studying biological macromolecules PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME 98 22 12468-12472 2001
  •  Link between the enzymatic and mechanical behavior in an actomyosin motor I. Amitani, T. Sakamoto, T. Ando Biophys. J. 80 379-397  2001
  •  Direct observation of processive movement by individual myosin V molecules Biochem. Biophys. Res. Commun. 272 586-590 2000
  •  Single-fluorophore imaging with an unmodified epifluorescence microscope and conventional video camera J. Microscopy 195 178-182 1999
  •  Scanning force microscopy of the interaction events between a single molecule of heavy meromyosin and actin Biochem. Biophys. Res. Commun. 234 178-182 1997
  •  High-speed Atomic Force Microscopy for Directly Visualizing Dynamic Biomolecular Processes 45 1 22-30 2010

Conference Presentations

  • Go to the lab website: http://www.s.kanazawa-u.ac.jp/phys/biophys/invited_talks.htm

Arts and Fieldwork

Patent

○Scan type probe microscope and active damping drive control device(publish date:2008/03)(country:Almost all countries)(No:WO 2008/029561 A1)
○Atomic Force Microscope(publish date:2008/03/01)(country:Almost all countries)(No:WO 2008/029562 A1)
○Scanning probe microscope and molecular structure change observation method.(publish date:2009/07/01)(country:USA)(No:US 7,556,968 B2)
○Scanning unit and scanning microscope having the same(publish date:2004/10/01)(country:USA)(No:US 6,809,306 B2)
○Scanning unit and scanning microscope having the same(publish date:2003/09/01)(country:USA)(No:US 6,617,761 B2)

Theme to the desired joint research

○Development of high-speed scanning probe microscopies

Grant-in-Aid for Scientific Research

○「高速AFMの高度化技術の開発とタンパク質の動作機序解析」(2014-2017) 
○「高速バイオAFMが拓く新構造生物学」(2012-2016) 
○「天然変性蛋白質」(2009-2013) 
○「生命現象の解明に資する革新的高速AFMの開発」(2008-2012) 
○「最高速AFMが解き明かす生物分子モーターのナノ構造ダイナミクス」(2003-2007) 
○「アクチンに形成される場で無生物は走るか?」(2004-2005) 

Classes (Bachelors)

Classes (Graduate Schools)

International Project

International Students

Lecture themes

Others (Social Activities)

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