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Researcher Information

last modified:2018/08/25

Associate Professor NINOMIYA Kazuaki

Mail Laboratory Website

Faculty, Affiliation

Institute for Frontier Science Initiative

College and School Educational Field


Laboratory

 TEL:076-234-4806 FAX:076-234-4806

Academic Background

【Academic background(Doctoral/Master's Degree)】
Osaka University Doctor 200303 Completed
【Degree】
Ph.D.

Career

Year & Month of Birth

1975/07

Academic Society

The Society for Biotechnology, Japan
Japan Society of Sonochemistry
Japan Bioindustry Association

Award

○UNK(2008/12)
○UNK(2005)
○UNK(2001/11)

Specialities

Bioproduction

Speciality Keywords

Bio-Production. BioChemical Engineering

Research Themes

A Researches aimed at protection of human health 1 ~Cancer therapy~:Drug delivery system 2 ~Regenerative medicine~:Tissue engineering B Researches aimed at protection of earth environment 1 ~Environmental detoxification~:Advanced oxidation process 2 ~Carbon neutral~:Biomass refinery

Books

  •  UNK NTS 2008/09
  •  UNK 2006/05

Papers

  •  Segmentation of plant hairy roots promotes lateral root emergence and subsequent growth Masahiro Kino-oka, Yoshio Hitaka, Kazuaki Ninomiya, Masahito Taya and Setsuji Tone JOURNAL OF BIOSCIENCE AND BIOENGINEERING 88 6 690-692 1999/01
  •  Elongating potential of pak-bung hairy roots under photoautotrophic culture condition Kazuaki Ninomiya, Hirofumi Nagatome, Masahiro Kino-oka and Masahito Taya JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 34 11 1396-1401 2001
  •  Segmental distribution in potentials of lateral root budding and oxygen uptake of plant hairy Roots BIOCHEMICAL ENGINEERING JOURNAL 10 1 77-80 2002
  •  Elongating responses to herbicides of heterotrophic and photoautotrophic hairy roots derived from pak-bung plant Kazuaki Ninomiya, Yoshihiro Oogami, Masahiro Kino-oka and Masahito Taya JOURNAL OF BIOSCIENCE AND BIOENGINEERING 93 5 505-508 2002
  •  Assessment of herbicidal toxicity based on non-destructive measurement of local chlorophyll content in photoautotrophic hairy roots Kazuaki Ninomiya, Yoshihiro Oogami, Masahiro Kino-oka and Masahito Taya JOURNAL OF BIOSCIENCE AND BIOENGINEERING 95 3 264-270 2003

show all

  •  Characterization of elongating potentials of root tips in terms of ATP contents in heterotrophic and photoautotrophic hairy roots of pak-bung Kazuaki Ninomiya, Yuki Tsushima, Masahiro Kino-oka and Masahito Taya JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 36 6 725-729 2003
  •  An automatic image analyzing system for evaluation of elongating behavior of plant hairy roots exposed to herbicidal stimuli Kazuaki Ninomiya, Yuki Tsushima, Masahiro Kino-oka and Masahito Taya JOURNAL OF BIOSCIENCE AND BIOENGINEERING 96 1 98-101 2003
  •  Differences in responses of plant hairy roots to chemical toxicity compared between primary and ramified roots Kazuaki Ninomiya, Motomu Nishioka, Masahiro Kino-oka and Masahito Taya Environ. Sci. 11 5 283-291 2004
  •  Aerobic culture of Propionibacterium freudenreichii ET-3 can increase production ratio of 1,4-dihydroxy-2-naphthoic acid to menaquinone JOURNAL OF BIOSCIENCE AND BIOENGINEERING 101 6 464-470 2006/06
  •  Optimal Aerobic Culture for 1,4-dihydorxy-2-napthoic Acid Production by Propionibacterium freudenreichii ET-3 JOURNAL OF BIOSCIENCE AND BIOENGINEERING 102 3 198-205 2006/09
  •  Effect of flocculation on performance of arming yeast in direct ethanol fermentation APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 70 5 573-579 2006/11
  •  Effect of neurosphere size on the growth rate of human neural stem/progenitor cells JOURNAL OF NEUROSCIENCE RESEARCH 84 8 1682-1691 2006/12
  •  Enhancement of ethanol production by promoting surface contact between starch granules and arming yeast in direct ethanol fermentation JOURNAL OF BIOSCIENCE AND BIOENGINEERING 103 1 95-97 2007/01
  •  Validation of a method for predicting the precision, limit of detection and range of quantitation in competitive ELISA ANALYTICAL SCIENCES 23 2 215-8 2007/02
  •  Microaeration enhances productivity of bioethanol from hydrolysate of waste house wood using ethanologenic Escherichia coli KO11 JOURNAL OF BIOSCIENCE AND BIOENGINEERING 103 4 350-357 2007/04
  •  Image cytometry for analyzing regional distribution of cells inside human neurosphere JOURNAL OF BIOSCIENCE AND BIOENGINEERING 103 4 384-387 2007/04
  •  Simulation model for predicting limit of detection and range of quantification of competitive enzyme-linked immunosorbent assay Dong Hwan Choi, Yoshio Katakura, Rieko Matsuda, Yuzuru Hayashi, Kazuaki Ninomiya, Suteaki Shioya 103 5 427-431 2007/05
  •  Enhancement of 1,4-dihydroxy-2-naphthoic acid production by Propionibacterium freudenreichii ET-3 fed-batch culture APPLIED AND ENVIRONMENTAL MICROBIOLOGY 73 10 3137-3143 2007/05
  •  Fed-batch coculture of Lactobacillus kefiranofaciens with Saccharomyces cerevisiae for effective production of kefiran JOURNAL OF BIOSCIENCE AND BIOENGINEERING 103 6 557-562 2007/06
  •  Strategies for reducing supplemental medium cost in bioethanol production from waste house wood hydrolysate by ethanologenic Escherichia coli: Inoculum size increase and co-culture with Saccharomyces cerevisiae JOURNAL OF BIOSCIENCE AND BIOENGINEERING 105 2 90-96 2008/02
  •  Rational screening of antibodies and design of sandwich enzyme linked immunosorbant assay on the basis of a kinetic model JOURNAL OF BIOSCIENCE AND BIOENGINEERING 105 3 261-72 2008/03
  •  Biological detoxification of waste house wood hydrolysate using Ureibacillus thermosphaericus for bioethanol production JOURNAL OF BIOSCIENCE AND BIOENGINEERING 106 2 128-33 2008/08
  •  Sonocatalytic facilitation of hydroxyl radical generation in the presence of TiO2 ULTRASONICS SONOCHEMISTRY 15 6 988-94 2008/09
  •  Effect of CO2 concentration on the growth and exopolysaccharide production of Bifidobacterium longum cultivated under anaerobic conditions. JOURNAL OF BIOSCIENCE AND BIOENGINEERING 107 5 535-537 2009/05
  •  Potential uses of titanium dioxide in conjunction with ultrasound for improved bacterial disinfection BIOCHEMICAL ENGINEERING JOURNAL 48 3 416-423 2010/02
  •  Lactic acid bacteria display on the cell surface cytosolic proteins that recognize yeast mannan APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 86 1 319-326 2010/03
  •  Ultrasound-induced cell damage and membrane lipid peroxidation of Escherichia coli in the presence of non-woven TiO2 fabrics ULTRASONICS SONOCHEMISTRY 17 4 738-743 2010/04
  •  Evaluation of extra- and intracellular OH radical generation, cancer cell injury, and apoptosis induced by a non-thermal atmospheric pressure plasma jet Kazuaki Ninomiya, Tatsuo Ishijima, Masatoshi Imamura, Takayuki Yamahara, Hiroshi Enomoto, Kenji Takahashi, Yasunori Tanaka, Yoshihiko Uesugi, Nobuaki Shimizu J. Phys. D: Appl. Phys. 46 42 425401 2013/10
  •  Enhanced OH radical generation by dual-frequency ultrasound with TiO2 nanoparticles: its application to targeted sonodynamic therapy Kazuaki Ninomiya, Kyohei Noda, Chiaki Ogino, Shun-ichi Kuroda, and Nobuaki Shimizu Ultrason. Sonochem. 21 1 289-294 2014/01
  •  Ultrasound-mediated drug delivery using liposomes modified with a thermosensitive polymer Kazuaki Ninomiya, Shinya Kawabata, Hiroyuki Tashita, and Nobuaki Shimizu  Ultrason. Sonochem. 21 1 310-316 2014/01
  •  Effect of ultrasound irradiation on bacterial internalization and bacteria-mediated gene transfer to cancer cells Ultrason. Sonochem. 21 3 1187-1193 2014/05
  •  Targeted and ultrasound-triggered drug delivery using liposomes co-modified with cancer cell-targeting aptamers and a thermosensitive polymer Kazuaki Ninomiya, Takahiro Yamashita, Shinya Kawabata, and Nobuaki Shimizu Ultrason. Sonochem. 21 4 2014/07
  •  Pretreatment of Japanese cedar by ionic liquid solutions in combination with acid and metal ion and its application to high solid loading Ogura, Kazuma; Ninomiya, Kazuaki; Takahashi, Kenji; Ogino, Chiaki; Kondo, Akihiko Biotechnology for Biofuels 7 1 2014/08/20 
  •  Microwave pretreatment of lignocellulosic material in cholinium ionic liquid for efficient enzymatic saccharification Kazuaki Ninomiya, Takashi Yamauchi, Chiaki Ogino, Nobuaki Shimizu, Kenji Takahashi Biochem Eng. J. 90 15 90-95 2014/09
  •  Targeted and sonocatalytic cancer cell injury using avidin-conjugated TiO2 nanoparticles Kazuaki Ninomiya, Aya Fukuda, Chiaki Ogino, and Nobuaki Shimizu Ultrason. Sonochem. 21 5 1624-1628 2014/09
  •  Characterization of fractionated biomass component and recovered ionic liquid during repeated process of cholinium ionic liquid-assisted pretreatment and fractionation CHEMICAL ENGINEERING JOURNAL 259 323-329 2015/01/01 
  •  Ionic liquid/ultrasound pretreatment and in situ enzymatic saccharification of bagasse using biocompatible cholinium ionic liquid Ninomiya, Kazuaki;Kohori, Asami;Tatsumi, Mai;Osawa, Koji;Endo, Takatsugu;Kakuchi, Ryohei;Ogino, Chiaki;Shimizu, Nobuaki;Takahashi, Kenji BIORESOURCE TECHNOLOGY 176 169-174 2015/01/01 
  •  Saccharification and ethanol fermentation from cholinium ionic liquid-pretreated bagasse with a different number of post-pretreatment washings BIORESOURCE TECHNOLOGY 189 203-209 2015/08/01
  •  Efficient and rapid direct transesterification reactions of cellulose with isopropenyl acetate in ionic liquids Ryohei Kakuchi, Makoto Yamaguchi, Takatsugu Endo, Yoshiki Shibata, Kazuaki Ninomiya, Tomoyuki Ikai, Katsuhiro Maeda Kenji Takahashi RSC adv. 5 72071-72074 2015/08/20
  •  Application of a non-thermal atmospheric pressure plasma jet to the decomposition of salicylic acid to inorganic carbon Kosuke Kuroda, Tatsuo Ishijima, Toshiki Kaga, Kai Shiomomura, Kazuaki Ninomiya, Kenji Takahashi Chemistry Letters 44 11 1473-1475 2015/11/05
  •  Effect of post-pretreatment washing on saccharification and co-fermentation from bagasse pretreated with biocompatible cholinium ionic liquid Kazuaki Ninomiya,Chiaki Ogino,Miki Ishizaki,Misa Yasuda,Nobuaki Shimizu,Kenji Takahashi Biochemical Engineering Journal 103 198-204 2015/11/15
  •  Transport properties of various ionic liquids during electrodialysis Takatsugu Endo, Koji Osawa, Mai Tatsumi, Kazuaki Ninomiya, Kenji Takahashi Journal of Solution Chemistry 44 12 2405-2415 2015/12
  •  Targeted and ultrasound-triggered cancer cell injury using perfluorocarbon emulsion-loaded liposomes endowed with cancer cell-targeting and fusogenic capabilities Kazuaki Ninomiya, Takahiro Yamashita, Yamato Tanabe, Miki Imai, Kenji Takahashi, Nobuaki Shimizu Ultrason. Sonochem. 28 54-61 2016/01
  •  Sonocatalytic injury of cancer cells attached on the surface of a nickel–titanium dioxide alloy plate Kazuaki Ninomiya, Hirotaka Maruyama, Chiaki Ogino, Kenji Takahashi, Nobuaki Shimizu Ultrason. Sonochem. 28 1-6 2016/01
  •  Hydrolysis of cellulose using an acidic and hydrophobic ionic liquid, and subsequent separation of glucose aqueous solution from the ionic liquid and 5-(hydroxymethyl)furfural Kosuke Kuroda, Kyohei Miyamura, Heri Satria, Kenji Takada, Kazuaki Ninomiya, Kenji Takahashi ACS Sustainable Chemistry & Engineering 4 6 3352-3356 2016/06
  •  Enhanced hydrolyisis of lignocellulosic biomass assisted by a combination of acidic ionic liquids and microwave heating Kosuke Kuroda, Ken Inoue, Kyohei Miyamura, Kenji Takada, Kazuaki Ninomiya, Kenji Takahashi J. Chem. Eng. Jpn 49 8 809-813 2016/08
  •  Anion bridging-induced structural transformation of cellulose dissolved in ionic liquid Takatsugu Endo, Shota Hosomi, Shunsuke Fujii, Kazuaki Ninomiya, Kenji Takahashi J Phys Chem Lett 7 24 5156-5161 2016/12/15
  •  A mechanistic insight into the organocatalytic properties of imidazolium-based ionic liquids and a positive co-solvent effect on cellulose modification reactions in an ionic liquid Ryohei Kakuchi, Ryo Ito, Shuhei Nomura, Hadi Abroshan, Kazuaki Ninomiya, Tomoyuki Ikai, Katsuhiro Maeda, Hyung J. Kim, Kenji Takahashi RSC Advances 7 16 9423-9430 2017/01/01
  •  Effective dissolution of biomass in ionic liquids by irradiation of non-thermal atmospheric pressure plasma Kosuke Kuroda, Kai Shimomura, Tatsuo Ishijima, Kazuaki Ninomiya, Kenji Takahashi Australian Journal of Chemistry 7 6 731-734 2017/01/01
  •  Efficient hydrolysis of polysaccharides in bagasse by in situ synthesis of an acidic ionic liquid after pretreatment Heri Satria, Kosuke Kuroda (co-first author), Takatsugu Endo, Kenji Takada, Kazuaki Ninomiya, Kenji Takahashi ACS Sustain. Chem. Eng. 5 1 708-713 2017/01/03
  •  Nano-Structural Investigation on Cellulose Highly Dissolved in Ionic Liquid: A Small Angle X-ray Scattering Study Takatsugu Endo, Shota Hosomi, Shunsuke Fujii, Kazuaki Ninomiya, Kenji Takahashi Molecules 22 1 178 2017/01/21
  •  Efficient Hydrolysis of Lignocellulose by Acidic Ionic Liquids under Low-Toxic Condition to Microorganisms Kosuke Kuroda, Ken Inoue, Kyohei Miyamura, Heri Satria, Kenji Takada, Kazuaki Ninomiya, Kenji Takahashi Catalysts 7 4 108 2017/04/01
  •  Efficient recovery of ionic liquid by electrodialysis in the acid hydrolysis process Takatsugu Endo, Mai Tatsumi, Kosuke Kuroda, Heri Satria, Yumiko Shimada, Kazuaki Ninomiya, Kenji Takahashi Separation Science and Technology 52 7 1240-1245 2017/05/03
  •  Viscosity effect of ionic liquid-assisted controlled growth of CH 3 NH 3 PbI 3 nanoparticle-based planar perovskite solar cells Md. Shahiduzzaman, Kohei Yamamoto, Yoshikazu Furumoto, Kyosuke Yonezawa, Keitarou Hamada, Kosuke Kuroda, Kazuaki Ninomiya, Makoto Karakawa, Takayuki Kuwabara, Kenji Takahashi, Kohshin Takahashi, Tetsuya Taima Organic Electronics 48 147-153 2017/09/01
  •  Recyclable and scalable organocatalytic transesterification of polysaccharides in a mixed solvent of 1-ethyl-3-methylimidazolium acetate and dimethyl sulfoxide Quy Van Nguyen, Shuhei Nomura, Rina Hoshino, Kazuaki Ninomiya, Kenji Takada, Ryohei Kakuchi, Kenji Takahashi Polymer Journal 49 11 783-787 2017/11/01
  •  Investigation of accessibility and reactivity of cellulose pretreated by ionic liquid at high loading Takatsugu Endo, Ei Mon Aung, Shunsuke Fujii, Shota Hosomi, Mitsugu Kimizu, Kazuaki Ninomiya, Kenji Takahashi Carbohydrate Polymers 176 365-373 2017/11/15
  •  Design of Wall-Destructive but Membrane-Compatible Solvents Kosuke Kuroda, Heri Satria, Kyohei Miyamura, Kazuaki Ninomiya, Kenji Takahashi Journal of the American Chemical Society 139 45 16052-16055 2017/11/15
  •  Development and evaluation of consolidated bioprocessing yeast for ethanol production from ionic liquid-pretreated bagasse Jerome Amoah, Naoya Ishizue, Miki Ishizaki, Misa Yasuda, Kenji Takahashi, Kazuaki Ninomiya, Ryosuke Yamada, Akihiko Kondo, Chiaki Ogino Bioresource Technology 245 Pt B 1413-1420 2017/12/01
  •  Ionic liquid pretreatment of bagasse improves mechanical property of bagasse/polypropylene composites Kazuaki Ninomiya, Megumi Abe, Takayuki Tsukegi, Kosuke Kuroda, Masaaki Omichi, Kenji Takada, Mana Noguchi, Yota Tsuge, Chiaki Ogino, Kentaro Taki, Tetsuya Taima, Kiyoshi Uzawa, Kenji Takahashi Industrial Crops and Products 109 158-162 2017/12/15
  •  Oxidative depolymerization potential of biorefinery lignin obtained by ionic liquid pretreatment and subsequent enzymatic saccharification of eucalyptus Kazuaki Ninomiya, Kobako Ochiai, Mao Eguchi, Kosuke Kuroda, Yota Tsuge, Chiaki Ogino, Tetsuya Taima, Kenji Takahashi Industrial Crops and Products 111 457-461 2018/01/01
  •  Lignocellulose nanofibers prepared by ionic iquid pretreatment and subsequent mechanical nanofibrillation of bagasse powder: Application to esterified bagasse/polypropylene composites Kazuaki Ninomiya, Megumi Abe, Takayuki Tsukegi, Kosuke Kuroda, Yota Tsuge, Chiaki Ogino, Kentaro Taki, Tetsuya Taima, Joji Saito, Mitsugu Kimizu, Kiyoshi Uzawa, Kenji Takahashi Carbohydrate Polymers 182 8-14 2018/02/15
  •  Pretreatment of bagasse with a minimum amount of cholinium ionic liquid for subsequent saccharification at high loading and co-fermentation for ethanol production Kazuaki Ninomiya, Amaliyah. Rohsari Indah Utami, Yota Tsuge, Kosuke Kuroda, Chiaki Ogino, Tetsuya Taima, Joji Saito, Mitsugu Kimizu, Kenji Takahashi Chemical Engineering Journal 334 657-663 2018/02/15

Conference Presentations

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「イオン液体を用いたリグニンのカスケード利用による完全型バイオマスリファイナリー」(2015-2018) 
○「イオン液体型架橋の相互作用を制御した自己修復性リグニンスルホン酸樹脂の開発」(2015-2016) 
○「抗がん剤耐性を示すがん幹細胞へ集積する超音波応答性ナノ粒子を用いたがん根治療法」(2012-2013) 
○「イオン液体とラジカルを利用したリグノセルロースのトータルリファイナリー」(2012-2014) 
○「腫瘍集積型光触媒ナノ粒子の創製と超音波力学的がん治療」(2010-2012) 
○「バイオエタノールの効率的生産を目指したスーパー酵母の育種」(2008-2009) 
○「低細胞毒性のセルロース溶媒を用いたリグノセルロースリファイナリー基盤技術の構築」(2010-2011) 
○「東南アジアにおける乳酸菌資源の学術調査及びデータベースの構築」(2004-2005) 
○「難培養共生微生物群追跡技術の確立とその産業利用」(2007-2008) 
○「分子標的ナノ粒子を用いた診断と治療を同時に行う超音波力学的がん治療」(2007-2009) 
○「ナイシンの高生産を目的とした高濃度ナイシン脱感作株の育種」(2006-2007) 
○「非分解性と信じられているプラスチックの分解酵素遺伝子のクローニング」(2004-2005) 
○「微生物共生システムを利用した発酵生産法の開発」(2003-2004) 

Classes (Bachelors)

○Biochemical Engineering(2017)
○Introduction of Biochemical Engineering(2017)
○Biomedical Engineering(2017)
○Basic Laboratory in Chemical and Biochemical Engineering(2017)
○Biomedical Engineering(2017)
○Introduction of Biochemical Engineering 2(2017)
○Introduction of Biochemical Engineering 1(2017)
○Introduction to Biology, Material Engineering and Geosciences A(2017)
○Internship(2017)
○Biochemical Engineering(2017)
○Bioreaction Engineering(2017)
○Biochemical Engineering(2017)
○Biomedical Engineering(2017)
○Biomedical Engineering(2017)
○Physical Biology(2017)
○Bioreaction Engineering(2017)
○Basic Laboratory in Chemical and Biochemical Engineering(2016)
○Presentation and Debate (Freshman Seminar II)(2016)
○Biomedical Engineering(2016)
○Basic Laboratory in Chemical and Biochemical Engineering(2016)
○Biomedical Engineering(2016)
○Experiments in Biochemical Engineering B(2016)
○Freshman Seminar I(2016)
○Physical Biology(2016)
○Internship(2016)
○Experiments in Biochemical Engineering A(2016)
○Introduction of Biochemical Engineering(2016)
○Biochemical Engineering(2016)

Classes (Graduate Schools)

○Fundamentals of Bioengineering(2017)
○Advanced Bioproduction Engineering 1(2017)
○Advanced Bioproduction Engineering 2(2017)
○Advanced Bioproduction Engineering 2(2017)
○Advanced Bioproduction Engineering 1(2017)
○Practice of Biorefinery(2017)
○Advanced Biorefinery(2017)
○Topics in Biochemical Engineering 2(2017)
○Advanced Biorefinery(2017)
○Advanced Bioproduction Engineering 2(2016)
○Fundamentals of Bioengineering(2016)
○Advanced Bioproduction Engineering 1(2016)
○Advanced Bioproduction Engineering 2(2016)
○Advanced Biorefinery(2016)
○Topics in Biochemical Engineering 2(2016)
○Practice of Biorefinery(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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