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Researcher Information

last modified:2019/08/05

Professor INOUE Hiroshi

Mail Laboratory Website

Faculty, Affiliation

Institute for Frontier Science Initiative
Professor

College and School Educational Field

Graduate School of Medical Science
Graduate School of Advanced Preventive Medical Sciences

Laboratory

Metabolism and Nutrition Research Unit, Institute for Frontier Science Initiative

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kobe University Doctor 200103 Completed
【Academic background(Bachelor's Degree)】
Kobe University 199403
【Degree】
Doctor of Medicine

Career

Year & Month of Birth

1969/12

Academic Society

Award

Specialities

Eating habits、Metabolomics、

Speciality Keywords

Research Themes

Books

Papers

  •  Nicotinic alpha 7 acetylcholine receptor deficiency exacerbates hepatic inflammation and fibrosis in a mouse model of non-alcoholic steatohepatitis. Kimura K, Inaba Y, Watanabe H, Matsukawa T, Matsumoto M, Inoue H. J Diabetes Investig. 2019
  •  PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeogenesis and insulin signalling in hepatocytes.  Yano H, Sakai M, Matsukawa T, Yagi T, Naganuma T, Mitsushima M, Iida S, Inaba Y, Inoue H, Unoki-Kubota H, Kaburagi Y, Asahara S, Kido Y, Minami S, Kasuga M, Matsumoto M. Sci Rep. 8 1 14290 2018/09/24
  •  Dietary soybean protein ameliorates high-fat diet-induced obesity by modifying the gut microbiota-dependent biotransformation of bile acids.  Watanabe K, Igarashi M, Li X, Nakatani A, Miyamoto J, Inaba Y, Sutou A, Saito T, Sato T, Tachibana N, Inoue H, Kimura I. PLoS One. 13 8 e0202083 2018/08/13
  •  Dietary mung bean protein reduces high-fat diet-induced weight gain by modulating host bile acid metabolism in a gut microbiota-dependent manner. Nakatani A, Li X, Miyamoto J, Igarashi J, Watanabe H, Sutou A, Watanabe K, Motoyama T, Tachibana N, Kohno M, Inoue H, Kimura I Biochem Biophys Res Commun. 501 4 955-961 2018/07/02
  •  PDGFRβ regulates adipose tissue expansion and glucose metabolism via vascular remodeling in diet-induced obesity. Diabetes. Onogi Y, Wada T, Kamiya C, Inata K, Matsuzawa T, Inaba Y, Kimura K, Inoue H, Yamamoto S, Ishii Y, Koya D, Tsuneki H, Sasahara M, Sasaoka T. Diabetes 66 4 1008-1021 2017/04

show all

  •  Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein.  Watanabe H, Inaba Y, Kimura K, Matsumoto M, Kaneko S, Kasuga M, Inoue H.  Nat Commun. 9 1 30 2018/01/02
  •  Dietary Mung Bean Protein Reduces Hepatic Steatosis, Fibrosis, and Inflammation in Male Mice with Diet-Induced, Nonalcoholic Fatty Liver Disease. Watanabe H, Inaba Y, Kimura K, Asahara SI, Kido Y, Matsumoto M, Motoyama T, Tachibana N, Kaneko S, Kohno M, Inoue H. J Nutr. 147 1 52 2017/01
  •  The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch.  Sakai M, Tujimura-Hayakawa T, Yagi T, Yano H, Mitsushima M, Unoki-Kubota H, Kaburagi Y, Inoue H, Kido Y, Kasuga M, Matsumoto M.  Nat Commun. 7 13147 2016/11/22
  •  Eicosapentaenoic acid ameliorates hyperglycemia in high-fat diet-sensitive diabetes mice in conjunction with restoration of hypoadiponectinemia. Morimoto M, Lee EY, Zhang X, Inaba Y, Inoue H, Ogawa M, Shirasawa T, Yokosuka O, Miki T. Nutr Diabetes.  6 e213 2016/06/27
  •  Molecular basis of brain-mediated regulation of hepatic glucose metabolism Inoue, Hiroshi Diabetology International 5 3 158-164 2014/01/01 
  •  Histidine Augments the Suppression of Hepatic Glucose Production by Central Insulin Action Kimura, Kumi;Nakamura, Yusuke;Inaba, Yuka;Matsumoto, Michihiro;Kido, Yoshiaki;Asahara, Shun-ichiro;Matsuda, Tomokazu;Watanabe, Hiroshi;Maeda, Akifumi;Inagaki, Fuyuhiko;Mukai, Chisato;Takeda, Kiyoshi;Akira, Shizuo;Ota, Tsuguhito;Nakabayashi, Hajime;Kaneko, Shuichi;Kasuga, Masato;Inoue, Hiroshi DIABETES 62 7 2266-2277 2013 
  •   Central Insulin Action Activates Kupffer Cells by Suppressing Hepatic Vagal Activation via the Nicotinic Alpha 7 Acetylcholine Receptor. Kimura K#, Tanida M#, Nagata N, Inaba Y, Watanabe H, Nagashimada M, Ota T, Asahara S, Kido Y, Matsumoto M, Toshinai K, Nakazato M, Shibamoto T, Kaneko S, Kasuga M, Inoue H. Cell Rep. 14 10 2362-74 2016
  •  Growth arrest and DNA damage-inducible 34 regulates liver regeneration in hepatic steatosis in mice. Hepatology. Inaba Y#, Furutani T#, Kimura K, Watanabe H, Haga S, Kido Y, Matsumoto M, Yamamoto Y, Harada K, Kaneko S, Oyadomari S, Ozaki M, Kasuga M, Inoue H. Hepatology. 61 4 1343-1356 2015
  •  Hypothalamic Orexin Prevents Hepatic Insulin Resistance via Daily Bidirectional Regulation of Autonomic Nervous System in Mice Tsuneki, Hiroshi;Tokai, Emi;Nakamura, Yuya;Takahashi, Keisuke;Fujita, Mikio;Asaoka, Takehiro;Kon, Kanta;Anzawa, Yuuki;Wada, Tsutomu;Takasaki, Ichiro;Kimura, Kumi;Inoue, Hiroshi;Yanagisawa, Masashi;Sakurai, Takeshi;Sasaoka, Toshiyasu DIABETES 64 2 459-470 2015/01/01 
  •  P62/SQSTM1 plays a protective role in oxidative injury of steatotic liver in a mouse hepatectomy model Haga, Sanae; Ozawa, Takeaki; Yamada, Yuma; Morita, Naoki; Nagashima, Izuru; Inoue, Hiroshi; Inaba, Yuka; Noda, Natsumi; Abe, Riichiro; Umezawa, Kazuo; Ozaki, Michitaka Antioxidants and Redox Signaling 21 18 2515-2530 2014/12/20 
  •   The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43.  Kimura I, Ozawa K, Inoue D, Imamura T, Kimura K, Maeda T, Terasawa K, Kashihara D, Hirano K, Tani T, Takahashi T, Miyauchi S, Shioi G, Inoue H, Tsujimoto G. Nat Commun. 4 1829 2013
  •  Regulation of glucose metabolism by central insulin action.  Biomedical Reviews. 22 31-39 2011/04
  •  Endoplasmic Reticulum Stress Inhibits STAT3-dependent Suppression of Hepatic Gluconeogenesis via Dephosphorylation and Deacetylation.  Kimura K, Yamada T, Matusmoto M, Kido Y, Hosooka T, Asahara S, Matsuda T, Ota T, Watanabe H, Sai Y, Miyamoto K, Kaneko S, Kasuga M, Inoue H DIABETES 61 1 61-73 2012/01

Conference Presentations

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「リアルタイムモニタリングによる蛋白質摂取の肝糖代謝への効果の検討」(2012-2013) 
○「肥満での肝脂肪蓄積調節異常における自律神経の役割」(2011-2012) 
○「ヒスチジン誘導体の糖代謝における役割」(2011-2013) 
○「肝細胞周期調節因子の肝糖脂質代謝における役割」(2009-2010) 

Classes (Bachelors)

Classes (Graduate Schools)

International Project

International Students

Lecture themes

Others (Social Activities)

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