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last modified：2025/04/03
Associate Professor HORIKE Shin-ichi
Faculty, Affiliation
Research Center for Experimental Modeling of Human Disease Division of Integrated Omics research
Associate Professor
College and School Educational Field
Graduate School of Medical Science
United Graduate School of Child Depelopment
School of Medical and Pharmaceutical Sciences, College of Medical,Pharmaceutical and Health Sciences
Course in Bioengineering, School of Biological Science and Technology, College of Science and Engineering
College of Human and Social Sciences
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
Laboratory
HORIKE LAB TEL:076-265-2775 FAX:076-234-4537
Academic Background
【Academic background(Bachelor's Degree)】
Shimane University Chemistry 199503
Career
Tottori University Research Fellow(2000/10/01-2001/07/14)
Lawrence Berkeley National Laboratory Life Science Division Research Fellow(2001/07/15-2004/06/30)
The Hospital for Sick Children Genetics & Genome Biology Research Fellow(2004/07/01-2006/09/30)
University of Tokushima Institute for enzyme research Assistant Professor(2006/10/01-2007/10/31)
Kanazawa University(2007/11/01-2012/03/31)
Year & Month of Birth
1972/12
Academic Society
The American Society of Human Genetics in USA
International Society for Autism Research
Award
○Award for(2018/07)
○Award for(2018/07)
Specialities
Epigenetics
Speciality Keywords
Genomic Imprinting,Rett syndrome,Epigenetics,Autism
Research Themes
Characterization of autism-associated genes on human X chromosome
Chromatin higher-order structure and dynamics at the imprinted 15q11-q13 locus
Long-distance chromatin mechanisms controlling imprinted expression on 7q32
Identification of a novel regulatory element of the OXTR gene
Books
- Nagai, M,Meguro-Horike, M,Horike, S DNA Methylation - From Genomics to Technology INTECH 2012/03
- Nagai, M., Meguro-Horike, M., Horike, S. DNA Methylation - From Genomics to Technology INTECH 2012/03
Papers
- Preparation and some properties of perfluoroalkoxy-substituted phthalocyanine complexes of iron(III), nickel(II) and zinc(II) T Sugimori,S Horike,M Handa,K Kasuga INORGANICA CHIMICA ACTA 278 2 253 1998/09
- Catalytic oxygenation of olefin with dioxygen and tetra-t-butylphthalocyanine complexes in the presence of sodium borohydride T Sugimori,S Horike,S Tsumura,M Handa,K Kasuga INORGANICA CHIMICA ACTA 283 1 275 1998/12
- Localization of an hTERT repressor region on human chromosome 3p21.3 using chromosome engineering. Satoshi Abe,Hiromi Tanaka,Tomomi Notsu,Shin-Ichi Horike,Chikako Fujisaki,Dong-Lai Qi,Takahito Ohhira,David Gilley,Mitsuo Oshimura,Hiroyuki Kugoh Genome integrity 1 1 6 2010/05/26
- Cortisol overproduction results from DNA methylation of CYP11B1 in hypercortisolemia Mitsuhiro Kometani,Takashi Yoneda,Masashi Demura,Hiroshi Koide,Koshiro Nishimoto,Kuniaki Mukai,Celso E. Gomez-Sanchez,Tadayuki Akagi,Takashi Yokota,Shin-ichi Horike,Shigehiro Karashima,Isamu Miyamori,Masakazu Yamagishi,Yoshiyu Takeda SCIENTIFIC REPORTS 7 1 11205 2017/09
- Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation Long Guo,Hiroshi Yamashita,Ikuyo Kou,Aki Takimoto,Makiko Meguro-Horike,Shin-ichi Horike,Tetsushi Sakuma,Shigenori Miura,Taiji Adachi,Takashi Yamamoto,Shiro Ikegawa,Yuji Hiraki,Chisa Shukunami PLOS GENETICS 12 1 2016/01
- Aberrant CpG methylation of the imprinting control region KvDMR1 detected in assisted reproductive technology-produced calves and pathogenesis of large offspring syndrome Noboru Hori,Makoto Nagai,Muneyuki Hirayama,Tomokazu Hirai,Keisuke Matsuda,Michiko Hayashi,Takaichi Tanaka,Tadashi Ozawa,Shin-ichi Horike ANIMAL REPRODUCTION SCIENCE 122 3-4 303 2010/12
- Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation Long Guo,Hiroshi Yamashita,Ikuyo Kou,Aki Takimoto,Makiko Meguro-Horike,Shin-Ichi Horike,Tetsushi Sakuma,Shigenori Miura,Taiji Adachi,Takashi Yamamoto,Shiro Ikegawa,Yuji Hiraki,Chisa Shukunami PLoS Genetics 12 1 e1005802 2016
- Identification of novel distant regulatory element in the OXTR gene locus Shin-Ichi Horike,Makiko Meguro,Saya Numata,Toshiya Honda,Gensaku Okada,Shigeru Yokoyama,Haruhiro Higashida GENES & GENETIC SYSTEMS 91 6 351 2016/12
- MMCT-mediated chromosome engineering technique applicable to functional analysis of lncRNA and nuclear dynamics. Meguro-Horike M,Horike S Methods in molecular biology (Clifton, N.J.) 2015
- Neuron-specific impairment of inter-chromosomal pairing and transcription in a novel model of human 15q-duplication syndrome Makiko Meguro-Horike,Dag H. Yasui,Weston Powell,Diane I. Schroeder,Mitsuo Oshimura,Janine M. LaSalle,Shin-ichi Horike HUMAN MOLECULAR GENETICS 20 19 3798 2011/10
- 15q11.2-13.3 chromatin analysis reveals epigenetic regulation of CHRNA7 with deficiencies in Rett and autism brain Dag H. Yasui,Haley A. Scoles,Shin-ichi Horike,Makiko Meguro-Horike,Keith W. Dunaway,Diane I. Schroeder,Janine M. LaSalle HUMAN MOLECULAR GENETICS 20 22 4311 2011/11
- Pancreatic solitary fibrous tumor causing ectopic adrenocorticotropic hormone syndrome Keigo Murakami,Yasuhiro Nakamura,Saulo J. A. Felizola,Ryo Morimoto,Fumitoshi Satoh,Kentaro Takanami,Hideki Katakami,Seiichi Hirota,Yoshiyu Takeda,Makiko Meguro-Horike,Shin-ichi Horike,Michiaki Unno,Hironobu Sasano MOLECULAR AND CELLULAR ENDOCRINOLOGY 436 C 268 2016/11
- DLX5 expression is monoallelic and Dlx5 is up-regulated in the Mecp2-null frontal cortex Masaru Miyano,Shin-ichi Horike,Shutao Cai,Mitsuo Oshimura,Terumi Kohwi-Shigematsu JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 12 4 1188 2008/08
- Screening of DNA Methylation at the H19 Promoter or the Distal Region of its ICR1 Ensures Efficient Detection of Chromosome 11p15 Epimutations in Russell-Silver Syndrome Shin-Ichi Horike,Jose Carlos P. Ferreira,Makiko Meguro-Horike,Sanaa Choufani,Adam C. Smith,Cheryl Shuman,Wendy Meschino,David Chitayat,Elaine Zackai,Stephen W. Scherer,Rosanna Weksberg AMERICAN JOURNAL OF MEDICAL GENETICS PART A 149A 11 2415 2009/11
- A translocation t(6;7)(p11-p12;q22) associated with autism and mental retardation: localization and identification of candidate genes at the breakpoints John B. Vincent,Sanaa Choufani,Shin-ichi Horike,Beata Stachowriak,Martin Li,Fred J. Dill,Christian Marshal,Monica Hrynchak,Elizabeth Pewsey,Kennedy C. Ukadike,Jan M. Friedman,Anand K. Srivastava,Stephen W. Scherer PSYCHIATRIC GENETICS 18 3 101 2008/06
- An inversion inv(4)(p12-p15.3) in autistic siblings implicates the 4p GABA receptor gene cluster JB Vincent,SI Horike,S Choufani,AD Paterson,W Roberts,P Szatmari,R Weksberg,B Fernandez,SW Scherer JOURNAL OF MEDICAL GENETICS 43 5 429 2006/05
- Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome S Horike,ST Cai,M Miyano,JF Cheng,T Kohwi-Shigematsu NATURE GENETICS 37 1 31 2005/01
- Construction of a novel human artificial chromosome vector for gene delivery M Katoh,F Ayabe,S Norikane,T Okada,H Masumoto,S Horike,Y Shirayoshi,M Oshimura BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 321 2 280 2004/08
- Targeted disruption of the human LIT1 locus defines a putative imprinting control element playing an essential role in Beckwith-Wiedemann syndrome S Horike,K Mitsuya,M Meguro,N Kotobuki,A Kashiwagi,T Notsu,TC Schulz,Y Shirayoshi,M Oshimura HUMAN MOLECULAR GENETICS 9 14 2075 2000/09
- Cumulative Impact of Polychlorinated Biphenyl and Large Chromosomal Duplications on DNA Methylation, Chromatin, and Expression of Autism Candidate Genes Keith W. Dunaway,M. Saharul Islam,Rochelle L. Coulson,S. Jesse Lopez,Annie Vogel Ciernia,Roy G. Chu,Dag H. Yasui,Isaac N. Pessah,Paul Lott,Charles Mordaunt,Makiko Meguro-Horike,Shin-ichi Horike,Ian Korf,Janine M. LaSalle CELL REPORTS 17 11 3035 2016/12
- Oxytocin for Male subjects with autism spectrum Disorder and comorbid intellectual Disabilities: a randomized Pilot study Toshio Munesue,Hiroyuki Nakamura,Mitsuru Kikuchi,Yui Miura,Noriyuki Takeuchi,Tokie Anme,Eiji Nanba,Kaori Adachi,Kiyotaka Tsubouchi,Yoshimichi Sai,Ken-ichi Miyamoto,Shin-ichi Horike,Shigeru Yokoyama,Hideo Nakatani,Yo Niida,Hirotaka Kosaka,Yoshio Minabe,Haruhiro Higashida FRONTIERS IN PSYCHIATRY 7 JAN 2016/01
- UBE3A-mediated regulation of imprinted genes and epigenome-wide marks in human neurons S. Jesse Lopez,Keith Dunaway,M. Saharul Islam,Charles Mordaunt,Annie Vogel Ciernia,Makiko Meguro-Horike,Shin-ichi Horike,David J. Segal,Janine M. LaSalle EPIGENETICS 12 11 982 2017
- Pathologic Active mTOR Mutation in Brain Malformation with Intractable Epilepsy Leads to Cell-Autonomous Migration Delay Sae Hanai,Sayuri Sukigara,Hongmei Dai,Tomoo Owa,Shin-ichi Horike,Taisuke Otsuki,Takashi Saito,Eiji Nakagawa,Naoki Ikegaya,Takanobu Kaido,Noriko Sato,Akio Takahashi,Kenji Sugai,Yuko Saito,Masayuki Sasaki,Mikio Hoshino,Yu-ichi Goto,Schuichi Koizumi,Masayuki Itoh AMERICAN JOURNAL OF PATHOLOGY 187 5 1177 2017/05
- Disease-specific alteration of karyopherin-α subtype establishes feed-forward oncogenic signaling in head and neck squamous cell carcinoma. Masaharu Hazawa,Kie Sakai,Akiko Kobayashi,Hironori Yoshino,Yoshihiro Iga,Yuki Iwashima,Kee Sing Lim,Dominic Chih-Cheng Voon,Yan-Yi Jiang,Shin-Ichi Horike,De-Chen Lin,Richard W Wong Oncogene 39 10 2212 2019/12/10
- Pillar[6]arene acts as a biosensor for quantitative detection of a vitamin metabolite in crude biological samples Masaya Ueno,Takuya Tomita,Hiroshi Arakawa,Takahiro Kakuta,Tada-aki Yamagishi,Jumpei Terakawa,Takiko Daikoku,Shin-ichi Horike,Sha Si,Kenta Kurayoshi,Chiaki Ito,Atsuko Kasahara,Yuko Tadokoro,Masahiko Kobayashi,Tsutomu Fukuwatari,Ikumi Tamai,Atsushi Hirao,Tomoki Ogoshi Communications Chemistry 3 1 2020/12
- Genetic and epigenetic analyses of aldosterone-producing adenoma with hypercortisolemia. Mitsuhiro Kometani,Takashi Yoneda,Masashi Demura,Daisuke Aono,Yuko Gondoh,Shigehiro Karashima,Koshiro Nishimoto,Masanori Yasuda,Shin-Ichi Horike,Yoshiyu Takeda Steroids 151 108470 2019/11
- Active K-RAS induces the coherent rotation of epithelial cells: A model for collective cell invasion in vitro. Hirata E,Ichikawa T,Horike SI,Kiyokawa E Cancer science 109 12 4045 2018/10
- Baf53a is involved in survival of mouse ES cells, which can be compensated by Baf53b Bo Zhu,Atsushi Ueda,Xiaohong Song,Shin-ichi Horike,Takashi Yokota,Tadayuki Akagi SCIENTIFIC REPORTS 7 1 14059 2017/10
- Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2. Tatsunori Nishimura,Asuka Nakata,Xiaoxi Chen,Kurumi Nishi,Makiko Meguro-Horike,Soichiro Sasaki,Kenji Kita,Shin-Ichi Horike,Kaori Saitoh,Keiko Kato,Kaori Igarashi,Takahiko Murayama,Susumu Kohno,Chiaki Takahashi,Naofumi Mukaida,Seiji Yano,Tomoyoshi Soga,Arinobu Tojo,Noriko Gotoh Oncogene 38 14 2464 2019/04
- Urinary microRNA biomarkers for detecting the presence of esophageal cancer. Yusuke Okuda,Takaya Shimura,Hiroyasu Iwasaki,Shigeki Fukusada,Ruriko Nishigaki,Mika Kitagawa,Takahito Katano,Yasuyuki Okamoto,Tamaki Yamada,Shin-Ichi Horike,Hiromi Kataoka Scientific reports 11 1 8508 2021/04/20
- Effect of potassium on DNA methylation of aldosterone synthase gene. Yoshimichi Takeda,Masashi Demura,Fen Wang,Shigehiro Karashima,Takashi Yoneda,Mitsuhiro Kometani,Daisuke Aomo,Atsushi Hashimoto,Shin-Ichi Horike,Makiko Meguro-Horike,Yoshiyu Takeda Journal of hypertension 39 5 1018 2021/03/03
- Bromodomain protein BRD4 inhibitor JQ1 regulates potential prognostic molecules in advanced renal cell carcinoma Takashi Sakaguchi,Hirofumi Yoshino,Satoshi Sugita,Kazutaka Miyamoto,Masaya Yonemori,Yoichi Osako,Makiko Meguro-Horike,Shin-Ichi Horike,Masayuki Nakagawa,Hideki Enokida Oncotarget 9 33 23003 2018/05/01
- Peripubertal High Fat Diet Promotes c-Myc Stabilization in Mammary Gland Epithelium. Nilakshi Kulathunga,Susumu Kohno,Paing Linn,Yuuki Nishimoto,Shin-Ichi Horike,Mikhail I Zaraiskii,Sharad Kumar,Hayato Muranaka,Chiaki Takahashi Cancer science 2020/05/21
- Molecular genetic analysis of inherited protein C deficiency caused by the novel large deletion across two exons of PROC. Tomoki Togashi,Makiko Meguro-Horike,Satomi Nagaya,Sayaka Sugihara,Tatsuo Ichinohe,Yuhei Araiso,Koichi Yamaguchi,Kotaro Mori,Yuta Imai,Kana Kuzasa,Shin-Ichi Horike,Hidesaku Asakura,Atsushi Watanabe,Eriko Morishita Thrombosis research 188 115 2020/03/10
- Epigenetic Regulation of Aldosterone Synthase Gene by Sodium and Angiotensin II. Yoshimichi Takeda,Masashi Demura,Fen Wang,Shigehiro Karashima,Takashi Yoneda,Mitsuhiro Kometani,Atsushi Hashimoto,Daisuke Aono,Shin-Ichi Horike,Makiko Meguro-Horike,Masakazu Yamagishi,Yoshiyu Takeda Journal of the American Heart Association 7 10 2018/05/08
- Biallelic KARS pathogenic variants cause an early-onset progressive leukodystrophy. Masayuki Itoh,Hongmei Dai,Shin-Ichi Horike,John Gonzalez,Yoshikazu Kitami,Makiko Meguro-Horike,Ichiro Kuki,Shuichi Shimakawa,Harumi Yoshinaga,Yoko Ota,Tetsuya Okazaki,Yoshihiro Maegaki,Shin Nabatame,Shin Okazaki,Hisashi Kawawaki,Naoto Ueno,Yu-Ichi Goto,Yoichi Kato Brain : a journal of neurology 142 3 560 2019/03/01
- Genetic analysis of a compound heterozygous patient with congenital factor X deficiency and regular replacement therapy with a prothrombin complex concentrate. Togashi T,Nagaya S,Nagasawa M,Meguro-Horike M,Nogami K,Imai Y,Kuzasa K,Sekiya A,Horike SI,Asakura H,Morishita E International journal of hematology 111 1 51 2019/10
- Treatment of RB1-intact hepatocellular carcinoma with CDK4/6 inhibitor combination therapy. Jindan Sheng,Susumu Kohno,Nobuhiro Okada,Nobuyuki Okahashi,Kana Teranishi,Fumio Matsuda,Hiroshi Shimizu,Paing Linn,Naoko Nagatani,Minako Yamamura,Kenichi Harada,Shin-Ichi Horike,Hiroshi Inoue,Seiji Yano,Sharad Kumar,Shunsuke Kitajima,Itsuki Ajioka,Chiaki Takahashi Hepatology (Baltimore, Md.) 74 4 1971 2021/04/30
- Activation-induced cytidine deaminase is a possible regulator of cross-talk between oocytes and granulosa cells through GDF-9 and SCF feedback system. Takashi Iizuka,Kousho Wakae,Masanori Ono,Takuma Suzuki,Yasunari Mizumoto,Kouichi Kitamura,Shin-Ichi Horike,Masamichi Muramatsu,Hiroshi Fujiwara Scientific reports 11 1 3833 2021/02/15
- Development of a Highly Potent Analogue and a Long-Acting Analogue of Oxytocin for the Treatment of Social Impairment-Like Behaviors. Wataru Ichinose,Stanislav M Cherepanov,Anna A Shabalova,Shigeru Yokoyama,Teruko Yuhi,Hiroaki Yamaguchi,Ayu Watanabe,Yasuhiko Yamamoto,Hiroshi Okamoto,Shinichi Horike,Junpei Terakawa,Takiko Daikoku,Mizuki Watanabe,Nariyasu Mano,Haruhiro Higashida,Satoshi Shuto Journal of medicinal chemistry 62 7 3297 2019/04/11
- Aging-associated impairment in metabolic compensation by subcutaneous adipose tissue promotes diet-induced fatty liver disease in mice. Taketani H,Nishikawa T,Nakajima H,Kodo K,Sugimoto S,Aoi W,Horike SI,Meguro-Horike M,Ishiba H,Seko Y,Umemura A,Yamaguchi K,Moriguchi M,Yasui K,Itoh Y Diabetes, metabolic syndrome and obesity : targets and therapy 12 1473 2019
- ROCK-dependent phosphorylation of NUP62 regulates p63 nuclear transport and squamous cell carcinoma proliferation Masaharu Hazawa,De-Chen Lin,Akiko Kobayashi,Yan-Yi Jiang,Liang Xu,Firli Rahmah Primula Dewi,Mahmoud Shaaban Mohamed,Hartono,Mitsutoshi Nakada,Makiko Meguro-Horike,Shin-Ichi Horike,H Phillip Koeffler,Richard W Wong EMBO Reports 19 1 73 2018
- Amplicons in breast cancers analyzed by multiplex ligation-dependent probe amplification and fluorescence In Situ hybridization. Ooi A,Inokuchi M,Horike SI,Kawashima H,Ishikawa S,Ikeda H,Nakamura R,Oyama T,Dobash Y Human pathology 85 33 2018/10
- The lack of terminal tubule cells in the submandibular gland of mice deficient in submandibular gland protein C. Hiroki Nakata,Jumpei Terakawa,Shin-Ichi Horike,Takiko Daikoku,Shoichi Iseki Cell and tissue research 381 2 229 2020/05/16
- A novel urinary microRNA biomarker panel for detecting gastric cancer. Hiroyasu Iwasaki,Takaya Shimura,Tamaki Yamada,Yusuke Okuda,Makoto Natsume,Mika Kitagawa,Shin-Ichi Horike,Hiromi Kataoka Journal of gastroenterology 54 12 1061 2019/12
- Cell Type-Specific Genetic Manipulation and Impaired Circadian Rhythms in Vip tTA Knock-In Mice. Yubo Peng,Yusuke Tsuno,Ayako Matsui,Yuichi Hiraoka,Kohichi Tanaka,Shin-Ichi Horike,Takiko Daikoku,Michihiro Mieda Frontiers in physiology 13 895633 2022
- A Novel Urinary miRNA Biomarker for Early Detection of Colorectal Cancer. Hiroyasu Iwasaki,Takaya Shimura,Mika Kitagawa,Tamaki Yamada,Ruriko Nishigaki,Shigeki Fukusada,Yusuke Okuda,Takahito Katano,Shin-Ichi Horike,Hiromi Kataoka Cancers 14 2 2022/01/17
- Identification and functional analysis of three novel genetic variants resulting in premature termination codons in three unrelated patients with hereditary antithrombin deficiency Yuta Imai,Satomi Nagaya,Yuhei Araiso,Makiko Meguro-Horike,Tomoki Togashi,Kensho Ohmori,Yuka Makita,Eiichi Sato,Toshiaki Yujiri,Yuta Nagamori,Shin-ichi Horike,Atsushi Watanabe,Eriko Morishita International Journal of Hematology 2022/12/16
- Kif26b contributes to the progression of interstitial fibrosis via migration and myofibroblast differentiation in renal fibroblast. Yuta Yamamura,Yasunori Iwata,Kengo Furuichi,Takahiro Kato,Naoki Yamamoto,Keisuke Horikoshi,Hisayuki Ogura,Koichi Sato,Megumi Oshima,Shiori Nakagawa,Taro Miyagawa,Shinji Kitajima,Tadashi Toyama,Akinori Hara,Norihiko Sakai,Miho Shimizu,Shinichi Horike,Takiko Daikoku,Ryuichi Nishinakamura,Takashi Wada FASEB journal : official publication of the Federation of American Societies for Experimental Biology 36 11 e22606 2022/11
- Interferon-gamma induced APOBEC3B contributes to Merkel cell polyomavirus genome mutagenesis in Merkel cell carcinoma. Lusheng Que,Yingfang Li,Teruki Dainichi,Iwao Kukimoto,Tomoaki Nishiyama,Yuri Nakano,Kaori Shima,Tadaki Suzuki,Yuko Sato,Shinichi Horike,Hideki Aizaki,Koichi Watashi,Takanobu Kato,Hussein H Aly,Noriyuki Watanabe,Kenji Kabashima,Kousho Wakae,Masamichi Muramatsu The Journal of investigative dermatology 142 7 1793 2021/12/27
- The transcription factor ATF3 switches cell death from apoptosis to necroptosis in hepatic steatosis in male mice Yuka Inaba,Emi Hashiuchi,Hitoshi Watanabe,Kumi Kimura,Yu Oshima,Kohsuke Tsuchiya,Shin Murai,Chiaki Takahashi,Michihiro Matsumoto,Shigetaka Kitajima,Yasuhiko Yamamoto,Masao Honda,Shun-ichiro Asahara,Kim Ravnskjaer,Shin-ichi Horike,Shuichi Kaneko,Masato Kasuga,Hiroyasu Nakano,Kenichi Harada,Hiroshi Inoue Nature Communications 14 1 2023/01/23
- Uterine Deletion of Bmal1 Impairs Placental Vascularization and Induces Intrauterine Fetal Death in Mice Masanori Ono,Natsumi Toyoda,Kyosuke Kagami,Takashi Hosono,Takeo Matsumoto,Shin-ichi Horike,Rena Yamazaki,Mitsuhiro Nakamura,Yasunari Mizumoto,Tomoko Fujiwara,Hitoshi Ando,Hiroshi Fujiwara,Takiko Daikoku International Journal of Molecular Sciences 23 14 2022/07
- First report of inherited protein S deficiency caused by paternal PROS1 mosaicism. Satomi Nagaya,Keiko Maruyama,Atsushi Watanabe,Makiko Meguro-Horike,Yuta Imai,Yuki Hiroshima,Shin-Ichi Horike,Koichi Kokame,Eriko Morishita Haematologica 107 1 330 2022/01/01
- MUSASHI-2 confers resistance to third-generation EGFR-tyrosine kinase inhibitor osimertinib in lung adenocarcinoma. Reheman Yiming,Yasuto Takeuchi,Tatsunori Nishimura,Mengjiao Li,Yuming Wang,Makiko Meguro-Horike,Takashi Kohno,Shin-Ichi Horike,Asuka Nakata,Noriko Gotoh Cancer science 112 9 3810 2021/09
- Topical estrogen application promotes cutaneous wound healing in db/db female mice with type 2 diabetes. Kanae Mukai,Shin-Ichi Horike,Makiko Meguro-Horike,Yukari Nakajima,Arya Iswara,Toshio Nakatani PloS one 17 3 e0264572 2022
- FOXP4 inhibits squamous differentiation of atypical cells in cervical intraepithelial neoplasia via an ELF3-dependent pathway. Takeo Matsumoto,Takashi Iizuka,Mitsuhiro Nakamura,Takuma Suzuki,Megumi Yamamoto,Masanori Ono,Kyosuke Kagami,Haruki Kasama,Kousho Wakae,Masamichi Muramatsu,Shin-Ichi Horike,Satoru Kyo,Yasuhiko Yamamoto,Yasunari Mizumoto,Takiko Daikoku,Hiroshi Fujiwara Cancer science 113 10 3376 2022/07/15
- AVP neurons act as the primary circadian pacesetter cells in vivo Yusuke Tsuno,Yubo Peng,Shin-ichi Horike,Kanato Yamagata,Mizuki Sugiyama,Takahiro J. Nakamura,Takiko Daikoku,Takashi Maejima,Michihiro Mieda bioRxiv 2022/08/05
- Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells Masaharu Hazawa,Dini Kurnia Ikliptikawati,Yuki Iwashima,De-Chen Lin,Yuan Jiang,Yujia Qiu,Kei Makiyama,Koki Matsumoto,Akiko Kobayashi,Goro Nishide,Lim Keesiang,Hironori Yoshino,Toshinari Minamoto,Takeshi Suzuki,Isao Kobayashi,Makiko Meguro-Horike,Yan-Yi Jiang,Takumi Nishiuchi,Hiroki Konno,H. Phillip Koeffler,Kazuyoshi Hosomichi,Atsushi Tajima,Shin-ichi Horike,Richard W. Wong Cell Chemical Biology 2023/11
- Comparison of the effects of inappropriate meal timing-induced and genetic models of circadian clock disruption on uterine mRNA expression profiles. Yuchen Chen,Takashi Hosono,Masanori Ono,Takiko Daikoku,Natsumi Toyoda,Satoshi Nomura,Kyosuke Kagami,Shunsuke Orisaka,Shin-Ichi Horike,Yifan Shi,Pingping Xu,Jun-Ichi Morishige,Tomoko Fujiwara,Hiroshi Fujiwara,Hitoshi Ando The Journal of nutrition 2024/10/10
- Epigenomic Alterations of the Human CYP11B Gene in Adrenal Zonation Yoshimichi Takeda,Masashi Demura,Takashi Yoneda,Shigehiro Karashima,Mitsuhiro Kometani,Daisuke Aono,Seigo Konishi,Shin-ichi Horike,Yasuhiro Nakamura,Yuto Yamazaki,Hironobu Sasano,Yoshiyu Takeda International Journal of Molecular Sciences 2024/11/07
- Nuclear transport surveillance of p53 by nuclear pores in glioblastoma Dini Kurnia Ikliptikawati,Nozomi Hirai,Kei Makiyama,Hemragul Sabit,Masashi Kinoshita,Koki Matsumoto,Keesiang Lim,Makiko Meguro-Horike,Shin-ichi Horike,Masaharu Hazawa,Mitsutoshi Nakada,Richard W. Wong Cell Reports 112882 2023/08
- Renal pharmacokinetic adaptation to cholestasis causes increased nephrotoxic drug accumulation by Mrp6 downregulation in mice Hiroshi Arakawa,Takumi Kawanishi,Dai Shengyu,Takumi Nishiuchi,Makiko Meguro-Horike,Shin-ichi Horike,Masahiro Sugimoto,Yukio Kato Journal of Pharmaceutical Sciences 2023/08
- The novel protein C variant p.C101F results in early intracellular degradation that drives type I protein C deficiency. Rikuto Yui,Satomi Nagaya,Ibuki Yasuda,Tomoki Togashi,Yuika Kikuchi,Kengo Saito,Makiko Meguro-Horike,Shin-Ichi Horike,Hiroshi Kawasaki,Hidekazu Nishikii,Eriko Morishita International journal of hematology 2025/02/10
- ASH2L, a COMPASS core subunit, is involved in the cell invasion and migration of triple-negative breast cancer cells through the epigenetic control of histone H3 lysine 4 methylation. Gerelsuren Batbayar,Akihiko Ishimura,Hanbing Lyu,Sasithorn Wanna-Udom,Makiko Meguro-Horike,Minoru Terashima,Shin-Ichi Horike,Takahisa Takino,Takeshi Suzuki Biochemical and biophysical research communications 669 19 2023/08/20
- Protein S deficiency caused by cryptic splicing due to the novel intron variant c.346+5G>C in PROS1 Satomi Nagaya,Tomoki Togashi,Masaharu Akiyama,Yuta Imai,Haruto Matsumoto,Haruka Moriya,Makiko Meguro-Horike,Ibuki Yasuda,Yuika Kikuchi,Yamato Kuwajima,Shin-ichi Horike,Atsushi Watanabe,Eriko Morishita Thrombosis Research 2023/06
- Role of organic anion transporter NPT4 in renal handling of uremic toxin 3-indoxyl sulfate Rikako Imamura,Masahiro Sugimoto,Shin-ichi Horike,Jumpei Terakawa,Kazuki Fujita,Ikumi Tamai,Takiko Daikoku,Yukio Kato,Hiroshi Arakawa Journal of Pharmaceutical Sciences 2024/04
- Targeting cis-regulatory elements of FOXO family is a novel therapeutic strategy for induction of leukemia cell differentiation. Kenta Kurayoshi,Yusuke Takase,Masaya Ueno,Kumiko Ohta,Kyoko Fuse,Shuji Ikeda,Takayoshi Watanabe,Yuki Nishida,Shin-Ichi Horike,Kazuyoshi Hosomichi,Yuichi Ishikawa,Yuko Tadokoro,Masahiko Kobayashi,Atsuko Kasahara,Yongwei Jing,Mahmoud I Shoulkamy,Makiko Meguro-Horike,Kensuke Kojima,Hitoshi Kiyoi,Hiroshi Sugiyama,Hiroki Nagase,Atsushi Tajima,Atsushi Hirao Cell death & disease 14 9 642 2023/09/29
- Functional analysis of two abnormal antithrombin proteins with different intracellular kinetics Yuta Imai,Satomi Nagaya,Yuhei Araiso,Makiko Meguro-Horike,Tomoki Togashi,Shin-ichi Horike,Hiroshi Kawasaki,Eriko Morishita Thrombosis Research 230 18 2023/10
- Identification of two de novo variants causing inherited antithrombin deficiency by quantitative analysis of variant alleles Tomoki Togashi,Satomi Nagaya,Makiko Meguro-Horike,Haruto Matsumoto,Yuta Imai,Koichi Yamaguchi,Yoshinari Fujii,Haruka Moriya,Yuika Kikuchi,Ibuki Yasuda,Shin-ichi Horike,Eriko Morishita Thrombosis Research 2023/11
- Epigenetic alterations of 11beta-hydroxysteroid dehydrogenase 1 gene in the adipose tissue of patients with primary aldosteronism. Yoshimichi Takeda,Masashi Demura,Mitsuhiro Kometani,Shigehiro Karashima,Daisuke Aono,Seigo Konishi,Shin-Ichi Horike,Makiko Meguro-Horike,Takashi Yoneda,Yoshiyu Takeda Endocrine journal 71 3 245 2024/03/28
- Androgen-responsive FOXP4 is a target for endometrial carcinoma. Kayo Kayahashi,Mahadi Hasan,Anowara Khatun,Susumu Kohno,Jumpei Terakawa,Shin-Ichi Horike,Natsumi Toyoda,Ayumi Matsuoka,Takashi Iizuka,Takeshi Obata,Masanori Ono,Yasunari Mizumoto,Chiaki Takahashi,Hiroshi Fujiwara,Takiko Daikoku Communications biology 7 1 740 2024/06/18
- Early parental deprivation during primate infancy has a lifelong impact on gene expression in the male marmoset brain. Haruka Shinohara,Makiko Meguro-Horike,Takashi Inoue,Miyuki Shimazu,Machiko Hattori,Hitoshi Hibino,Kazumasa Fukasawa,Erika Sasaki,Shin-Ichi Horike Scientific reports 14 1 330 2024/01/03
- In vivo recording of suprachiasmatic nucleus dynamics reveals a dominant role of arginine vasopressin neurons in circadian pacesetting Yusuke Tsuno,Yubo Peng,Shin-ichi Horike,Mohan Wang,Ayako Matsui,Kanato Yamagata,Mizuki Sugiyama,Takahiro J. Nakamura,Takiko Daikoku,Takashi Maejima,Michihiro Mieda PLOS Biology 21 8 2023/08/29
- Endoplasmic reticulum transporter OAT2 regulates drug metabolism and interaction. Hiroshi Arakawa,Naoki Ishida,Tomoki Nakatsuji,Natsumi Matsumoto,Rikako Imamura,Dai Shengyu,Karin Araya,Shin-Ichi Horike,Rieko Tanaka-Yachi,Mureo Kasahara,Takako Yoshioka,Yuto Sumida,Hirohisa Ohmiya,Takiko Daikoku,Tomohiko Wakayama,Kazuaki Nakamura,Ken-Ichi Fujita,Yukio Kato Biochemical pharmacology 225 116322 2024/07
- Early parental deprivation during primate infancy has a lifelong impact on gene expression in the male marmoset brain Shinohara H., Meguro-Horike M., Inoue T., Shimazu M., Hattori M., Hibino H., Fukazawa K., Sasaki E., Horike S. Scientific Reports 2024/01
- Overlapping role of c-Jun N-terminal kinase (JNK) 1 and 2 in imidazole ketone erastin-induced ferroptosis. Odongoo R., Gunarta K.I., Erdenebaatar P., Suzuki R., Meguro-Horike M., Horike S., Endo Y., Fujii T., Fukunaga R., Yoshioka K. Gene Reports, 33 2023/12
- Potential therapeutic target secretogranin II might cooperate with hypoxia-inducible factor 1α in sunitinib-resistant renal cell carcinoma Fukumoto W., Yoshino H., Horike S-I., Kawakami I., Tamai M., Arima J., Kawahara I., Mitsuke A., Sakaguchi T., Inoguchi S., Meguro-Horike M., Tatarano S., Enokida H. Cancer Science 114 10 3946-3956 2023/10
Conference Presentations
- A noncoding imprinted RNA, MESTIT1 is essential for the repression in cis of KLF14(conference：62th Annual Meeting; The American Society of Human Genetics)(2012/11/06)
- The spliced lncRNA SNORD116HG is essential for the high order chromatin dynamics of the MAGEL2 and NDN locus over long distance.(2018/09/19)
Others
- コルチゾール産生腫瘍の体細胞変異はDNAメチル化に影響しているか 米谷充弘,出村昌史,唐島成宙,米田隆,小出寛,堀家慎一,西本鉱嗣郎,向井邦晃,山岸正和,武田仁勇 日本高血圧学会総会プログラム・抄録集 39th 331 2016/09/30
- レット症候群の発症機序の解明~MeCP2ターゲット遺伝子LBX1の同定とその作用機序の解明~ 堀家慎一,奥村兼汰,岡田源作,目黒牧子 日本生化学会大会(Web) 90th ROMBUNNO.1P‐1218 (WEB ONLY) 2017
- レット症候群の発症機序の解明~MeCP2ターゲット遺伝子LBX1の同定とその作用機序の解明~ 堀家慎一,奥村兼汰,岡田源作,目黒牧子 日本遺伝学会大会プログラム・予稿集 89th 109 2017/08/28
- ヒトLIT1遺伝子座は染色体ドメインレベルのインプリンティングセンターとして機能する 堀家慎一,三ツ矢幸造,目黒牧子,白吉安昭,押村光雄 Japanese Journal of Cancer Research 91 Supplement (Sept) 69 2000/09/01
- Beckwith‐Wiedemann症候群の責任遺伝子座LIT1は11p15.5領域のインプリンティングセンターとして機能する 三ツ矢幸造,堀家慎一,目黒牧子,神田将和,柏木明子,加藤基伸,白吉安昭,押村光雄 生化学 72 8 636 2000/08/25
- Chromatin Dynamics of the autism susceptibility locus 15q11-q13 Horike Shin-ichi,Meguro Makino THE CELL 49 8 35 2017/07
- コルチゾール自律産生を伴うアルドステロン産生腺腫におけるゲノム・エピゲノム解析 西本 優弥,米谷 充弘,権藤 侑子,木村 友美,蘇馬 由依,東谷 拓弥,青野 大輔,橋本 篤,唐島 成宙,出村 昌史,堀家 慎一,米田 隆,武田 仁勇 日本高血圧学会総会プログラム・抄録集 41回 PB01 2018/09
- レット症候群の発症機序の解明~MeCP2ターゲット遺伝子LBX1の同定~ 堀家慎一,奥村兼汰,岡田源作,目黒牧子 エピゲノムはどこまで操れるようになったか 第11回日本エピジェネティクス研究会年会プログラム集 理研シンポジウム 平成29年 71 2017
- 長鎖ノンコーディングRNAのマイルストーン研究 転写制御lncRNA 4.インプリントlncRNAによる染色体ドメインレベルの遺伝子発現制御 目黒牧子,堀家慎一 実験医学 33 20 3278 2015/12/10
- Molecular analysis of 8 autism patients with cytogenetic abnormalities John Vincent,Christian Marshall,Abdul Noor,Christian Windpassinger,Shin-ichi Horike,Sanaa Choufani,Beata Stachowiak,Jennifer Skaug,Leon Sloman,Peter Kroisel,Erwin Petek,Wendy Roberts,Stephen Scherer AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 141B 7 714 2006/10
- インプリンティングドメインの制御センターとしてのアンチセンスRNA,LIT1 堀家慎一,三ツ矢幸造,目黒牧子,寿典子,柏木明子,白吉安昭,押村光雄 日本分子生物学会年会プログラム・講演要旨集 23rd 608 2000/11/25
- The human LIT1 CpG island is a putative imprinting control element playing an essential role in Beckwith-Wiedemann syndrome. S Horike,K Mitsuya,M Meguro,N Kotobuki,A Kashiwagi,T Notsu,F Ayabe,Y Shirayoshi,M Oshimura AMERICAN JOURNAL OF HUMAN GENETICS 69 4 571 2001/10
- ニワトリDT40細胞株を用いたヒトLIT1 CpGアイランド領域のターゲティング 堀家慎一,三ツ矢幸造,目黒牧子,SCHULZ T C,久郷裕之,白吉安昭,押村光雄 日本分子生物学会年会プログラム・講演要旨集 22nd 456 1999/11/22
- An inversion INV (4) (p12-p15.3) associated with autism implicates the 4p GABA receptor gene cluster JB Vincent,S Choufani,S Horike,J Skaug,B Fernandez,SW Scherer AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 138B 1 71 2005/09
- 広汎性神経発達障害に関連する15q11‐q13ゲノム刷り込み領域のアレル特異的クロマチンダイナミクスの解析 堀家慎一,POWELL Weston,YASUI Dag H,LASALLE Janine M,目黒牧子 日本人類遺伝学会大会プログラム・抄録集 57th 141 2012
- 自閉症発症機序におけるエピゲノムの重要性~オキシトシンレセプタープロモーター領域のDNAメチル化解析~ 堀家慎一,岡田源作,棟居俊夫,東田陽博,横山茂,目黒牧子 日本人類遺伝学会大会プログラム・抄録集 58th 163 2013
- オキシトシンレセプターのエピゲノム異常と自閉症 堀家慎一,赤木佐千代,目黒牧子 先進医薬研究振興財団 2014年度 研究成果報告集 2014年度 40 2015
- オキシトシン受容体遺伝子の発現制御機構の解明 堀家慎一,目黒牧子,沼田紗弥,沼田紗弥,本田俊哉,本田俊哉,岡田源作,横山茂,東田陽博 日本分子生物学会年会プログラム・要旨集(Web) 39th ROMBUNNO.2P‐0162 (WEB ONLY) 2016
- オキシトシンレセプター遺伝子の発現制御機構の解明 堀家慎一,目黒牧子,沼田紗弥,沼田紗弥,本田俊哉,本田俊哉,岡田源作,横山茂,東田陽博 日本遺伝学会大会プログラム・予稿集 88th 129 2016/08/22
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「エピゲノム編集技術によるレット症候群の新規治療方法の開発」(2022-2024)
○「命をつなぐ染色体～遺伝子の運び屋である染色体を観察しよう～」(2021-2021)
○「新規胚シグナルlaeverinの幹細胞と免疫システムに対する作用の解明と臨床応用」(2021-2024)
○2020「命をつなぐ染色体～遺伝子の運び屋である染色体を観察しよう～」(2020-2020)
○2023「概日リズムに基づく妊娠・産褥期セルフケアプログラムの開発-光と食による制御の検討」(2020-2023)
○「性特異的なエピゲノム制御による自閉症発症機序の解明」(2019-2021)
○「生後早期の母子関係を評価する新規バイオマーカーの開発 -発達障害回避を目指して-」(2019-2020)
○「Y染色体微小重複が男性不妊症に与える影響－Y染色体は微小欠失だけではない－」(2019-2021)
○「染色体の空間的配置と組織特異的遺伝子発現制御機構の解明」(2011-2012)
○「LINE1配列のストランド特異的分布とMARを介したクロマチン制御機構の解明」(2016-2018)
○「神経細胞特異的なクロマチンダイナミクスを司る分子の同定」(2013-2015)
○「性特異的なエピゲノム制御による自閉症発症機序の解明」(2019-2021)
○「15q11-13染色体ペアリングに着目した自閉症発症機構の解明」(2009-2010)
○「核マトリックスを介した長鎖ncRNA,UBE3A-ATSのクロマチン制御機構」(2010-2011)
○「ヒトDMRにおける母性メチル化インプリント確立メカニズムの解明」(2011-2012)
○「インプリント長鎖非コードRNAの核内動態とクロマチンダイナミクスの解析」(2012-2013)
○「エピジェネティック因子MBD5による発達障害発症機序の解明」(2014-2016)
○「核内足場クロマチン構造を介したncRNA, IPWの作動機序の解明」(2015-2016)
○「レット症候群の早期診断と治療を目指した統合的研究」(2013-)
○「レット症候群の診断と予防・治療法確立のための臨床および生物科学の集学的研究」(2009-2011)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＡ(2024)
○Laboratory animal science and stem cell biology(2024)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＡ(2024)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＡ(2024)
○Laboratory animal science and stem cell biology(2024)
○Laboratory animal science and stem cell biology(2024)
○Laboratory animal science and stem cell biology(2024)
○Basic Experiments in Bioengineering B(2024)
○Introduction to Researches in Bioengineering(2024)
○Neuro- and Physiological Psychology B(2024)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＡ(2023)
○Laboratory animal science and stem cell biology(2023)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＡ(2023)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＡ(2023)
○Laboratory animal science and stem cell biology(2023)
○Laboratory animal science and stem cell biology(2023)
○Laboratory animal science and stem cell biology(2023)
○Neuro- and Physiological Psychology B(2023)
○Laboratory animal science and stem cell biology(2022)
○Laboratory animal science and stem cell biology(2022)
○Laboratory animal science and stem cell biology(2022)
○Laboratory animal science and stem cell biology(2022)
○Neuro- and Physiological Psychology B(2022)
○Neuro- and Physiological Psychology B(2021)
○Laboratory animal science and stem cell biology(2021)
○Neuropsychology A(2020)
○Laboratory animal science and stem cell biology(2020)
○Neuro- and Physiological Psychology A(2020)
Classes (Graduate Schools)
○Gene Engineering Basic Course(2024)
○Seminar on Advanced Medical Science(2024)
○Laboratory Rotation Ｉ(2024)
○Laboratory RotationⅠ(2024)
○Laboratory RotationⅠ(2024)
○Laboratory RotationⅡ(2024)
○Seminar on Animal Experimentation(2024)
○Laboratory RotationⅠ(2024)
○Laboratory Rotation I(2024)
○Laboratory Rotation I(2024)
○Seminar on Advanced Medical Science(2023)
○Gene Engineering Basic Course(2023)
○Laboratory Rotation I(2023)
○Basic Training on Medical Researches(2023)
○Basic Training on Medical Researches(2023)
○Laboratory RotationⅠ(2023)
○Intensive Lectures on Medical Researches(2023)
○Intensive Lectures on Medical Researches(2023)
○Basic Training on Medical Researches(2023)
○Basic Training on Medical Researches(2023)
○Intensive Lectures on Medical Researches(2023)
○Intensive Lectures on Medical Researches(2023)
○Laboratory RotationⅡ(2023)
○Basic Training on Medical Researches(2023)
○Intensive Lectures on Medical Researches(2023)
○Intensive Lectures on Medical Researches(2023)
○Seminar on Animal Experimentation(2023)
○Basic Training on Medical Researches(2023)
○Laboratory RotationⅠ(2023)
○Laboratory Rotation I(2023)
○Laboratory Rotation I(2023)
○Seminar on Advanced Medical Science(2022)
○Gene Engineering Basic Course(2022)
○Basic Training on Medical Researches(2022)
○Basic Training on Medical Researches(2022)
○Basic Training on Medical Researches(2022)
○Basic Training on Medical Researches(2022)
○Intensive Lectures on Medical Researches(2022)
○Intensive Lectures on Medical Researches(2022)
○Basic Training on Medical Researches(2022)
○Basic Training on Medical Researches(2022)
○Basic Training on Medical Researches(2022)
○Basic Training on Medical Researches(2022)
○Intensive Lectures on Medical Researches(2022)
○Intensive Lectures on Medical Researches(2022)
○Basic Training on Medical Researches(2022)
○Basic Training on Medical Researches(2022)
○Intensive Lectures on Medical Researches(2022)
○Seminar on Animal Experimentation(2022)
○Basic Training on Medical Researches(2022)
○Basic Training on Medical Researches(2022)
○Intensive Lectures on Medical Researches(2022)
○Gene Engineering Basic Course(2022)
○Seminar on Advanced Medical Science(2022)
○Gene Engineering Basic Course(2021)
○Basic Training on Medical Researches(2021)
○Seminar on Advanced Medical Science(2021)
○Intensive Lectures on Medical Researches(2021)
○Seminar on Animal Experimentation(2021)
○Seminar on Advanced Medical Science(2017)
○Gene Engineering Basic Course(2017)
○Seminar on Animal Experimentation(2017)
○Seminar on Animal Experimentation(2016)