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last modified：2025/04/03
Assistant Professor KOZAKA, Takashi
Faculty, Affiliation
Research Center for Experimental Modeling of Human Disease Division of Probe Chemistry for Disease Analysis
College and School Educational Field
Laboratory
Division of Probe Chemistry for Disease Analysis
Academic Background
【Degree】
Ph.D.
Career
Year & Month of Birth
Academic Society
Japanese Society for Molecular Imaging
The Japanese Society of Nuclear Medicine
Japanese Society of Radiation Safety Management
The Pharmaceutical Society of Japan
Japan Radioisotope Association
The Pharmaceutical Society of Japan
Award
Specialities
Speciality Keywords
Organic synthetic chemistry, Radiopharmaceutical chemistry, Molecular imaging
Research Themes
Books
Papers
- Antitumor agents. 284. New desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents. Kyoko Nakagawa-Goto,Pei-Chi Wu,Chin-Yu Lai,Ernest Hamel,Hao Zhu,Liying Zhang,Takashi Kozaka,Emika Ohkoshi,Masuo Goto,Kenneth F Bastow,Kuo-Hsiung Lee Journal of medicinal chemistry 54 5 1244 2011/03/10
- Introduction of radiobromine labeled decalinvesamicol analogue as a new and promising PET vesicular acetylcholine transporter (VAChT) imaging probe Azim Anwar-ul,Takashi Kozaka,Izumi Uno,Daisuke Miwa,Yoji Kitamura,Kazuma Ogawa,Keiichi Kawai,Yasushi Kiyono,Kazuhiro Shiba JOURNAL OF NUCLEAR MEDICINE 55 2014/05
- Development and evaluation of a novel radioiodinated vesamicol analog as a sigma receptor imaging agent. Kazuma Ogawa,Hiroya Kanbara,Kazuhiro Shiba,Yoji Kitamura,Takashi Kozaka,Tatsuto Kiwada,Akira Odani EJNMMI research 2 1 54 2012/09/28
- Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease. Olga Lopatina,Toru Yoshihara,Tomoko Nishimura,Jing Zhong,Shirin Akther,Azam A K M Fakhrul,Mingkun Liang,Chiharu Higashida,Kohei Sumi,Kazumi Furuhara,Yuki Inahata,Jian-Jung Huang,Keita Koizumi,Shigeru Yokoyama,Takahiro Tsuji,Yulia Petugina,Andrei Sumarokov,Alla B Salmina,Koji Hashida,Yasuko Kitao,Osamu Hori,Masahide Asano,Yoji Kitamura,Takashi Kozaka,Kazuhiro Shiba,Fangfang Zhong,Min-Jue Xie,Makoto Sato,Katsuhiko Ishihara,Haruhiro Higashida Frontiers in behavioral neuroscience 8 133 133 2014
- Stereoselective total syntheses of three Lycopodium alkaloids, (-)-magellanine, (+)-magellaninone, and (+)-paniculatine, based on two Pauson-Khand reactions. Takashi Kozaka,Naoki Miyakoshi,Chisato Mukai The Journal of organic chemistry 72 26 10147 2007/12/21
- Regional Brain Imaging of Vesicular Acetylcholine Transporter Using o-[I-125]Iodo-trans-decalinvesamicol as a New Potential Imaging Probe Takashi Kozaka,Izumi Uno,Yoji Kitamura,Daisuke Miwa,Mohammad Anwar-Ul Azim,Kazuma Ogawa,Kazuhiro Shiba SYNAPSE 68 3 107 2014/03
- Decontamination of radioactivity from contaminated vegetables derived from the Fukushima nuclear accident Kazuhiro Shiba,Yoji Kitamura,Takashi Kozaka,Izumi Uno,Kikuo Shimizu,Kazuyoshi Masumoto,Masahiro Hirota,Shogo Higaki,Hirokazu Miyoshi,Takuya Saze,Minoru Sakama,Makoto Yanaga RADIATION MEASUREMENTS 55 1 26 2013/08
- Development and evaluation of a radiobromine-labeled sigma ligand for tumor imaging. Kazuma Ogawa,Hiroya Kanbara,Yasushi Kiyono,Yoji Kitamura,Tatsuto Kiwada,Takashi Kozaka,Masanori Kitamura,Tetsuya Mori,Kazuhiro Shiba,Akira Odani Nuclear medicine and biology 40 4 445 2013/05
- Characteristics of radioactive contamination of vegetables derived from the Fukushima nuclear accident Shiba Kazuhiro,Kitamura Yoji,Kozaka Takashi,Uno Izumi,Shimizu Kikuo,Hirota Masahiro,Higaki Shogo,Masumoto Kazuyoshi Radiation Safety Management 11 1 19 2012
- Antitumor agents 273. Design and synthesis of N-alkyl-thiocolchicinoids as potential antitumor agents. Takashi Kozaka,Kyoko Nakagawa-Goto,Qian Shi,Chin-Yu Lai,Ernest Hamel,Kenneth F Bastow,Arnold Brossi,Kuo-Hsiung Lee Bioorganic & medicinal chemistry letters 20 14 4091 2010/07/15
- Chemical removal of radionuclides in contaminated spinach derived from the Fukushima nuclear accident Shiba Kazuhiro,Kitamura Yoji,Kozaka Takashi,Uno Izumi,Miyoshi Hirokazu,Yanaga Makoto Radiation Safety Management 11 1 23 2012/07
- Syntheses and in vitro evaluation of decalinvesamicol analogues as potential imaging probes for vesicular acetylcholine transporter (VAChT). Takashi Kozaka,Izumi Uno,Yoji Kitamura,Daisuke Miwa,Kazuma Ogawa,Kazuhiro Shiba Bioorganic & medicinal chemistry 20 16 4936 2012/08/15
- Synthesis and evaluation of a new vesamicol analog o-[(11)C]methyl-trans-decalinvesamicol as a PET ligand for the vesicular acetylcholine transporter. Yoji Kitamura,Takashi Kozaka,Daisuke Miwa,Izumi Uno,Mohammad Anwar-Ul Azim,Kazuma Ogawa,Junichi Taki,Seigo Kinuya,Kazuhiro Shiba Annals of nuclear medicine 30 2 122 2016/02
- Synthesis and evaluation of a new vesamicol analog o-[C-11]methyl-trans-decalinvesamicol as a PET ligand for the vesicular acetylcholine transporter Yoji Kitamura,Takashi Kozaka,Daisuke Miwa,Izumi Uno,Mohammad Anwar-ul Azim,Kazuma Ogawa,Junichi Taki,Seigo Kinuya,Kazuhiro Shiba ANNALS OF NUCLEAR MEDICINE 30 2 122 2016/02
- Preparation and evaluation of an astatine-211-labeled sigma receptor ligand for alpha radionuclide therapy. Kazuma Ogawa,Yoshiaki Mizuno,Kohshin Washiyama,Kazuhiro Shiba,Naruto Takahashi,Takashi Kozaka,Shigeki Watanabe,Atsushi Shinohara,Akira Odani Nuclear medicine and biology 42 11 875 2015/11
- The potential of o-bromo-trans-decalinvesamicol as a new PET ligand for vesicular acetylcholine transporter imaging. Mohammad Anwar-Ul Azim,Takashi Kozaka,Izumi Uno,Daisuke Miwa,Yoji Kitamura,Kazuma Ogawa,Akira Makino,Yasushi Kiyono,Kazuhiro Shiba Synapse (New York, N.Y.) 68 10 445 2014/10
- Characteristics of 2-[ 4-(2-iodophenyl) piperidino] cyclopenntanon (OI5V) as a new siguma-1 receptor imaging agent. Taiki Shigeno,Takashi Kozaka,Yoji Kitamura,Kazuma Ogawa,Kazuhiro Shiba JOURNAL OF NUCLEAR MEDICINE 58 2017/05
- In Vivo Differences between Two Optical Isomers of Radioiodinated o-iodo-trans-decalinvesamicol for Use as a Radioligand for the Vesicular Acetylcholine Transporter Izumi Uno,Takashi Kozaka,Daisuke Miwa,Yoji Kitamura,Mohammad Anwar-ul Azim,Kazuma Ogawa,Junichi Taki,Seigo Kinuya,Kazuhiro Shiba PLOS ONE 11 1 2016/01
- (-)-o-[11 C]methyl-trans-decalinvesamicol ((-)-[11 C]OMDV) as a PET ligand for the vesicular acetylcholine transporter. Daisuke Miwa,Yoji Kitamura,Takashi Kozaka,Taiki Shigeno,Kazuma Ogawa,Junichi Taki,Seigo Kinuya,Kazuhiro Shiba Synapse (New York, N.Y.) 74 11 e22176 2020/11
- Syntheses and evaluation of a homologous series of aza-vesamicol as improved radioiodine-labeled probes for sigma-1 receptor imaging. Kazuma Ogawa,Ryohei Masuda,Kenji Mishiro,Mengfei Wang,Takashi Kozaka,Kazuhiro Shiba,Seigo Kinuya,Akira Odani Bioorganic & medicinal chemistry 27 10 1990 2019/05/15
- In Vivo Differences between Two Optical Isomers of Radioiodinated o-iodo-trans-decalinvesamicol for Use as a Radioligand for the Vesicular Acetylcholine Transporter. Izumi Uno,Takashi Kozaka,Daisuke Miwa,Yoji Kitamura,Mohammad Anwar-Ul Azim,Kazuma Ogawa,Junichi Taki,Seigo Kinuya,Kazuhiro Shiba PloS one 11 1 e0146719 2016
- Development of a radiobromine-labeled compound as a sigma receptor ligand for tumor imaging Ogawa Kazuma,Mizuno Yoshiaki,Makino Akira,Masuda Ryohei,Kozaka Takashi,Kitamura Yoji,Kiyono Yasushi,Shiba Kazuhiro,Odani Akira JOURNAL OF NUCLEAR MEDICINE 57 2016/05/01
- 125I-labeled 2-[4-(2-iodophenyl)piperidino]cyclopentanol (125I-OI5V) imaging visualized augmented sigma-1 receptor expression according to the severity of myocardial ischemia Hiroshi Wakabayashi,Hiroshi Mori,Tomo Hiromasa,Norihito Akatani,Anri Inaki,Takashi Kozaka,Yoji Kitamura,Kazuma Ogawa,Seigo Kinuya,Junichi Taki Journal of Nuclear Cardiology 2022/08/01
- Syntheses and evaluation of azavesamicol homologous as radioiodine labeled probes for sigma-1 receptor imaging Ogawa Kazuma,Masuda Ryohei,Mishiro Kenji,Wang Mengfei,Kozaka Takashi,Shiba Kazuhiro,Kinuya Seigo,Odani Akira JOURNAL OF NUCLEAR MEDICINE 60 2019/05/01
- Visualization of Dynamic Expression of Myocardial Sigma-1 Receptor After Myocardial Ischemia and Reperfusion Using Radioiodine-Labeled 2-[4-(2-iodophenyl)piperidino]cyclopentanol (OI5V) Imaging. Hiroshi Wakabayashi,Junichi Taki,Hiroshi Mori,Tomo Hiromasa,Norihito Akatani,Anri Inaki,Takashi Kozaka,Kazuhiro Shiba,Kazuma Ogawa,Seigo Kinuya Circulation journal : official journal of the Japanese Circulation Society 85 11 2102 2021/06/26
- In vitro and in vivo evaluation of [125/123I]-2-[4-(2-iodophenyl)piperidino]cyclopentanol([125/123I]-OI5V) as a potential sigma-1 receptor ligand for SPECT. Taiki Shigeno,Takashi Kozaka,Yoji Kitamura,Kazuma Ogawa,Junichi Taki,Seigo Kinuya,Kazuhiro Shiba Annals of nuclear medicine 35 2 167 2021/02
- Combination of gemcitabine and anti-PD-1 antibody enhances the anticancer effect of M1 macrophages and the Th1 response in a murine model of pancreatic cancer liver metastasis. Tuyen Thuy Bich Ho,Alessandro Nasti,Akihiro Seki,Takuya Komura,Hiiro Inui,Takashi Kozaka,Yoji Kitamura,Kazuhiro Shiba,Taro Yamashita,Tatsuya Yamashita,Eishiro Mizukoshi,Kazunori Kawaguchi,Takashi Wada,Masao Honda,Shuichi Kaneko,Yoshio Sakai Journal for immunotherapy of cancer 8 2 2020/11
- Development of a novel radiobromine-labeled sigma-1 receptor imaging probe. Kazuma Ogawa,Ryohei Masuda,Yoshiaki Mizuno,Akira Makino,Takashi Kozaka,Yoji Kitamura,Yasushi Kiyono,Kazuhiro Shiba,Akira Odani Nuclear medicine and biology 61 28 2018/06
- Evaluation of Ga-DOTA-(D-Asp)n as bone imaging agents: D-aspartic acid peptides as carriers to bone. Kazuma Ogawa,Atsushi Ishizaki,Kenichiro Takai,Yoji Kitamura,Akira Makino,Takashi Kozaka,Yasushi Kiyono,Kazuhiro Shiba,Akira Odani Scientific reports 7 1 13971 2017/10/25
Conference Presentations
- Development of a novel σ-2 receptor ligand, MILV, and basic evaluation as an imaging probe(conference：144th Annual Meeting of the Pharmaceutical Society of Japan)(2024/03/29)
- 125I-Labeled 2-[4-(2-iodophenyl)piperidino]cyclopentanol (OI5V) imaging Visualized Augmented Sigma-1 Receptor Expression by Depending on the Severity of Myocardial Ischemia(2022/09/11)
- Development of PET / SPECT probes for Vesicular acetylcholine transporter (VAChT) imaging(2021/11/04)
- Usefulness of radioiodinated 2-[4-(2-iodophenyl)piperidino]cyclopentanol(OI5V) for early diagnosing neurodegenerative disorder caused by stress.(conference：12th World Congress of the World Federation of Nuclear Medicine and Biology)(2018/04/21)
- Study on the Application of ATR for the Measurement of Infrared Absorption Spectrum of Food Adductives Identification Tests(conference：139th Annual Meeting of the Pharmaceutical Society of Japan)(2019/03/23)
- Changes in cholinergic nervous system (VAChT) in stress-bearing mice(conference：139th Annual Meeting of the Pharmaceutical Society of Japan)(2019/03/21)
- Measurement of σ-1 receptor density in the duplication 15q mouse model by [125I]OI5V (conference：139th Annual Meeting of the Pharmaceutical Society of Japan)(2019/03/23)
- Involvement of P-glycoprotein on brain migration of VAChT imaging agent (OIDV)(conference：139th Annual Meeting of the Pharmaceutical Society of Japan)(2019/03/23)
- Development of a imaging probe for diagnosing stress-related neurodegenerative disorder(conference：The 58th Annual Scientific Meeting of the Japanese Society of Nuclear Medicine)(2018/11/16)
- Development of radioiodinated sigma-1 receptor ligands(conference：138th Annual Meeting of the Pharmaceutical Society of Japan)(2018/03/27)
- Study on the Application of ATR for the Measurement of Infrared Absorption Spectrum of Food Adductives Identification Tests(conference：138th Annual Meeting of the Pharmaceutical Society of Japan)(2018/03/26)
- The development of a novel σ-1 receptor imaging agent for SPECT(2017/05/26)
- Characteristics of 2-[4-(2-iodophenyl)piperidino]cyclopentanol (OI5V) as a new sigma-1 receptor imaging agent(conference：2017 SNMMI 64th annual meeting)(2017/06/13)
- Study on the Application of ATR for the Measurement of Infrared Absorption Spectrum of Food Adductives Identification Tests(conference：137th Annual Meeting of the Pharmaceutical Society of Japan)(2017/03/26)
- The structure-activity relationship between structure of vesamicol analogs and affinity of VAChT and sigma receptors.(conference：137th Annual Meeting of the Pharmaceutical Society of Japan)(2017/03/26)
- The possibility of vesamicol analog with 5-membered ring as a sigma-1 receptor imaging probe(conference：137th Annual Meeting of the Pharmaceutical Society of Japan)(2017/03/26)
- Changes of the dopamine nerve system by stress in the model mouse for 15q duplication.(conference：137th Annual Meeting of the Pharmaceutical Society of Japan)(2017/03/25)
- Development and evaluation of a radiobromine labeled sigma ligand for tumor imaging(conference：EANM'11 Annual Congress of the European Association of Nuclear Medicine)(2011/10/17)
- The radioactivity removal of contaminated vegetables caused by the Fukushima nuclear accident(conference：The 7th International Workshop on Ionizing Radiation Monitoring)(2011/12/04)
- Difference of biodistribution of (+)-[125I]-pIV by rodent species and contribution of the metabolite to long-term accumulation in tumor(2011/03/30)
- Developement of o-iodo-trans-decalinvesamicol (OIDV) as a potential VAChT imaging prove(2011/03/30)
- Study on the Measurement of Infrared Absorption Spectrum of a Food Additive Neotame(2011/03/30)
- Brain uptake of Oxytocin, potential therapeutic agent for autism(2011/03/30)
- Study on the brain uptake and metabolism of Oxytocin, a possible pharmaceutical for autism.(2012/03/29)
- Removal of radioactivity in the contaminated vegetables caused by the Fukushima nuclear accident(2012/03/29)
- The development of VAChT-imaging probes for early diagnosis of Alzheimer's disease(2012/03/30)
- Study on the Application of ATR for the Measurement of Infrared Absorption Spectrum of a Food Additive(2012/03/31)
- Study on a radiomeal-octabromoporphyrin complex as a tumor imaging agent.(2012/05/31)
- Development of a radiobromine-labeled compound as a sigma receptor ligand for tumor imaging(conference：2016 SNMMI 63th annual meeting)(2016/06/13)
- In vitro Evaluation of meta-bromo benzovesamicol (MBBzV) as a Potential Vesicular Acetylcholine Transporter (VAChT) Imaging Probe(2016/05/05)
- Regional brain distribution of the dopamine nerve system of CD157/BST1 knockout mouse(2016/03/29)
- The possibility of the sigma receptor as the target of the early imaging of the stress disorder(2016/03/28)
- The development study on new sigma-2 receptor selective ligands based on vesamicol(2016/03/28)
- Study of radiomeal-octabromoporphyrin complex as a tumor diagnostic agent(2014/06/14)
- Introduction of radiobromine labeled decalinvesamicol analogue as a new and promising PET vesicular acetylcholine transporter (VAChT) imaging probe(conference：2014 SNMMI 61th annual meeting)(2014/06/08)
- A new and promising VAChT imaging probe for PET: Radiobromine labeled analogue of decalinvesamicol(2014/03/28)
- ヨードベンゼンからの18F化法(2014/02/08)
- Evaluation of radiolabeled o-bromo-trans-decalinvesamicol (OBDV) as a PET ligand for the vesicular acetylcholine transporter (VAChT)(conference：International Workshop for Molecular Functional Imaging -Brain and Gynecologic Oncology-)(2014/03/03)
- In vivo evaluation of radiobromine-labeled o-bromo-trans-decalinvesamicol (OBDV) as a potential VAChT imaging probe(2013/12/14)
- In vivo evaluation of radiomeal-octabromoporphyrin complex as a tumor imaging agent」(2013/06/28)
- In vivo evaluation of radioiodinated o-iodo-trans-decalinvesamicol(OIDV) as a vesicular acetylcholine transporter (VAChT) imaging agent.(conference：2013 SNMMI 60th annual meeting)(2013/06/10)
- The development of potential vesicular acetylcholine transporter (VAChT) PET imaging probes(conference：2013 SNMMI 60th annual meeting)(2013/06/10)
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「シグマ-2受容体を標的とする中枢神経系疾患イメージング剤の開発」(2023-2025)
○2022「σ受容体を標的とした新規固形がんイメージング剤と抗がん剤の開発」(2020-2022)
○「シグマ受容体イメージングによるストレス性疾患の客観的早期診断法の開発」(2019-2021)
○「固形腫瘍の画像診断及びホウ素中性子捕捉療法を目的としたσ-2受容体標的薬剤の開発」(2017-2019)
○「アルツハイマー病の早期診断用シナプス前コリン作動性神経分子イメージング剤の開発」(2014-2017)
○「固形腫瘍の早期発見・増殖能診断を目的としたσ-2受容体イメージング剤の開発研究」(2014-2016)
○「脳内σ—１受容体イメージングによる老化及びストレス性疾患の客観的評価に関する研究」(2011-2013)
○「アルツハイマー病の早期診断を目的としたコリントランスポーターイメージング剤の開発」(2011-2013)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Radiation Measurement Experiment 2(2022)
○Radiochemistry Experiment(2022)
○Radiation Measurement Experiment 2(2022)
○Radiochemistry Experiment(2022)
○Radiation Measurement Experiment 2(2021)
○Radiochemistry Experiment(2021)
○Radiation Measurement Experiment 2(2020)
○Radiochemistry Experiment(2020)
○Radioisotope in In-Vitro and In-Vivo Techniques(2020)
○Radiochemistry Experiment(2019)
○Radioisotope in In-Vitro and In-Vivo Techniques(2019)
○Radiation Measurement Experiment 2(2019)
○Radioisotope in In-Vitro and In-Vivo Techniques(2018)
○Radiation Measurement Experiment 2(2017)
○Radiochemistry Experiment(2017)
○Radioisotope in In-Vitro and In-Vivo Techniques(2017)
○Radiochemistry Experiment(2016)
○Radioisotope in In-Vitro and In-Vivo Techniques(2016)
○Radiation Measurement Experiment 2(2016)
Classes (Graduate Schools)
○Seminar on Advanced Medical Science(2022)
○Seminar on Advanced Medical Science(2022)
○Seminar on Advanced Medical Science(2021)
○Seminar on Advanced Medical Science(2020)
○Introduction to Basic Medical Science(2020)
○Introduction to Basic Medical Science(2019)
○Seminar on Advanced Medical Science(2019)
○Introduction to Basic Medical Science(2018)
○Seminar on Advanced Medical Science(2018)
○Seminar on Advanced Medical Science(2017)
○Introduction to Basic Medical Science(2016)
○Seminar on Advanced Medical Science(2016)