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Researcher Information

last modified:2024/01/08

Associate Professor OSHIMA Hiroko

Mail Laboratory Website

Faculty, Affiliation

Cancer Research Institute

College and School Educational Field

Division of Pharmacy, Graduate School of Medical Science


Division of genetics TEL:076-265-2724 FAX:076-234-4519

Academic Background

【Academic background(Bachelor's Degree)】
Kumamoto University 199203


1992-1997 Banyu Tsukuba Research Institute
1997-2000 Merck Research Laboratory
2001-2005 Kyoto University

Year & Month of Birth


Academic Society



Experimental pathology

Speciality Keywords

Research Themes

Inflammatory responses in gastrointestinal tumorigenesis

Inflammatory responses in gastrointestinal tumorigenesis Inflammation and related induction of PGE2 pathway play an important role in gastrointestinal tumorigenesis. Gastritis in mice by transgenic expression of COX-2 and mPGES-1 or infection with Helicobacter causes SPEM development, which may contribute to gastric tumorigenesis.

Generation of inflammation-associated gastric cancer mouse model

Generation of inflammation-associated gastric cancer mouse model Activation of Wnt signaling and suppression of BMP pathway are both thought to cause gastric tumorigenesis. However, mouse model with Wnt activation or BMP suppression in the stomach did not develop tumors. Importantly, induction of gastritis by PGE2 induction in these model mice results in development of adenocarcinoma and hamartoma, respectively. These results indicate importance of inflammatory responses for gastric tumorigenesis.



  •  Activation of epidermal growth factor receptor signaling by the prostaglandin E2 receptor EP4 pathway during gastric tumorigenesis.  Oshima H, Popivanova BK, Oguma K, Kong D, Ishikawa T, and Oshima M.  Cancer Science 2011/04
  •  Platelet 12-lipoxigenase accelerates tumor promotion of mouse epidermal cells through enhancement of cloning efficiency. Piao Y, Du Y, Oshima H, Jin J, Nomura M, Yoshimoto T, Oshima M 2008
  •  Activated macrophages promote Wnt signaling through tumor necrosis factor-alpha in gastric tumor cell. Oguma K, Oshima H, Aoki M, Uchio R, Naka K, Nakamura S, Hirao A, Saya H, Taketo MM, Oshima M 2008
  •  Induction and downregulation of Sox17 and its possible roles during the course of gastrointestinal tumorigenesis Du YC, Oshima H, Oguma K, Kitamura T, Itadani H, Fujimura T, Piao YS, Yoshimoto T, Minamoto T, Taketo MM, Oshima M. GASTROENTEROLOGY 2009/09
  •  Induction of prostaglandin E2 pathway promotes gastric hamartoma development with suppression of bone morphogenetic protein signaling Oshima H, Itadani H, Kotani H, Taketo MM, Oshima M. CANCER RESEARCH 69 7 2729-2733 2009/04

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  •  Wnt activation and PGE2 induction. Oshima H, and Oshima M PATHOLOGY INTERNATIONAL 2010/09
  •  Prostaglandin E2 signaling and bacterial infection recruit tumor-promoting macrophages to mouse gastric tumors Oshima H, Hioki K, Popivanova BK, Oguma K, van Rooijen N, and Oshima M GASTROENTEROLOGY 2011/01
  •  ProstaglandinE2, Wnt, and BMP in gastric tumor mouse models Hiroko Oshima. Keisuke Oguma, Yu-Chen Du and Masanobu Oshima Cancer Science 2009/10
  •  Inteatinal cancer progression by mutant p53 though the acquisition of invasiveness associated with complex glandular formation. Nakayama M, Sakai E, Echizen K, Yamada Y, Oshima H, Han TS, Ohki R, Fujii S, Ochiai A, Robine S, Voon DC, Tanaka T, Taketo MM, Oshima M. Oncogene 36 42 5885-5896 2017/10/19

Conference Presentations


  •  Increased levels of serum vascular endothelial growth factor by long-term exposure to hypergravity. Oshima M, Suzuki H, Guo X, Oshima H 56 4 309-313 2007
  •  Suppression of intestinal polyposis in Apcd716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Oshima, M., Dinchuk, J. E., Kargman, S. L., Oshima, H., Hancock, B., Kwong, E., Trzaskos, J. M., Evans, J. F., and Taketo. M. M. 1996
  •  Morphological and molecular processes of polyp formation in Apcd716 knockout mice. Oshima, H., Oshima, M., Kobayashi, M., Tsutsumi, M., and Taketo, M. M. 1997
  •  Hepatocarcinogenesis in mice with beta-catenin and Ha-ras gene mutstions. Harada, N., Oshima, H., Katoh, M., Tamai, Y., Oshima, M., and Taketo, M. M. 2004
  •  Hyperplastic gastric tumors induced by activated macrophages in COX-2/mPGES-1 transgenic mice. Oshima, H., Oshima, M., Inaba, K., and Taketo, M. M. 2004

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  •  Hypergravity induces expression of cyclooxygenase-2 in the heart vessels. Oshima, M., Oshima, H., and Taketo, M. M. 2005
  •  Hyperplastic gastric tumors with spasmolytic polypeptide-expressing metaplasia (SPEM) caused by TNF-a-dependent inflammation in COX-2/mPGES-1transgenic mice. Oshima M, Oshima H, Matsunaga A, and Taketo MM. 2005
  •  Carcinogenesis in mouse stomach by simultaneous activation of the Wnt signaling and prostaglandin E2 pathway. Oshima H, Matsunaga A, Fujimura T, Tsukamoto T, Taketo MM, and Oshima M. 2006
  •  Destruction of pancreatic b-cells by transgenic induction of prostaglandin E2 in the islets. Oshima H, Taketo MM, and Oshima M. 2006
  •  Stromal fibroblasts activated by tumor cells promote angiogenesis in mouse gastric cancer . Guo X, Kitamura T, Taketo MM, Oshima M 2008/05
  •  Prostaglandin E2, Wnt and BMP in gastric tumor mouse models Oshima H, Oguma K, Du YC, Oshima M. Wiley InterScience 2009/09

Arts and Fieldwork


Theme to the desired joint research

Grant-in-Aid for Scientific Research


Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

Classes (Graduate Schools)

○Molecular Genetics of Tumor Biology(2017)
○Molecular Genetics of Tumor Biology(2017)
○Seminar on Tumor Biology(2016)
○Molecular Genetics of Tumor Biology(2016)
○Molecular Genetics of Tumor Biology(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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