Jump to contents

Researcher Information

last modified:2019/02/15

Assistant Professor ISHIMURA Akihiko

Mail Laboratory Website

Faculty, Affiliation

Cancer Research Institute

College and School Educational Field

Division of Cancer Medicine, Graduate School of Medical Science


Division of Functional Genomics TEL:076-264-6741 FAX:076-234-4502

Academic Background

【Academic background(Doctoral/Master's Degree)】
Niigata University Doctor 200103 Completed
【Academic background(Bachelor's Degree)】
Niigata University 199603
Master of Science
PhD (Science)


2001-2002, National Cancer Institute (USA), Postdoctoral Fellow National Cancer Institute (USA) Postdoctoral Fellow(2001/04-2002/03)
2002-2003, JSPS Research Fellowship National Cancer Institute (USA) Postdoctoral Fellow(2002/03-2003/10)
2003-2007, Postdoctoral Fellow (Akita Univ.) Akita Univ. Postdoctoral Fellow(2003/11-2007/03)
2007, Postdoctoral Fellow (Akita Univ.) Akita Univ. Postdoctoral Fellow(2007/04-2007/06)
2007-, Kanazawa Univ., Assistant Profesor Cancer Research Institute(2007/07-)

Year & Month of Birth


Academic Society

The Japanese Cancer Association
The Molecular Biology Society of Japan



General anatomy (including histology/embryology)

Speciality Keywords

Research Themes

Functional analysis of Jmjd5, a candidate cancer gene identified by retroviral insertional mutagenesis



  •  GATA-1 inhibits the formation of notochord and neural tissue in Xenopus embryo. Shibata, K., Ishimura, A. and Maeno, M. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 252 1  241-248 1998/11
  •  Contribution of JNK, Mek, Mos and PI-3K signaling to GVBD in Xenopus oocytes. Mood, K., Bong, Y. S., Lee, H. S., Ishimura, A. and Daar, I. O. CELLULAR SIGNALLING 16 5  631-642 2004/05
  •  Tyr-298 in ephrinB1 is critical for an interaction with the Grb4 adaptor protein. Bong, Y. S., Park, Y. H., Lee, H. S., Mood, K., Ishimura, A. and Daar, I. O. BIOCHEMICAL JOURNAL 377  499-507 2004/01
  •  The essential vertebrate ABCE1 protein interacts with eukaryotic initiation factors. Chen, Z. Q., Dong, J., Ishimura, A., Daar, I., Hinnebusch, A. G. and Dean, M. JOURNAL OF BIOLOGICAL CHEMISTRY 281 11  7452-7457 2006/03
  •  Oncogenic Met receptor induces cell-cycle progression in Xenopus oocytes independent of direct Grb2 and Shc binding or Mos synthesis, but requires phosphatidylinositol 3-kinase and Raf signaling. Mood, K., Saucier, C., Ishimura, A., Bong, Y. S., Lee, H. S., Park, M. and Daar, I. O. JOURNAL OF CELLULAR PHYSIOLOGY 207 1  271-285 2006/04

show all

  •  Oncogenic Met receptor induces ectopic structures in Xenopus embryos. Ishimura, A., Lee, H. S., Bong, Y. S., Saucier, C., Mood, K., Park, E. K. and Daar, I. O. ONCOGENE 25 31  4286-4299 2006/07
  •  Man1, an inner nuclear membrane protein, regulates vascular remodeling by modulating transforming growth factor beta signaling. Ishimura, A., Ng, J. K., Taira, M., Young, S. G. and Osada, S. DEVELOPMENT 133 19  3919-3928 2006/10
  •  Man1, an inner nuclear membrane protein, regulates left-right axis formation by controlling nodal signaling in a node-independent manner. Ishimura A, Chida S and Osada S. DEVELOPMENTAL DYNAMICS 237 12  3565-3576 2008/12
  •  Jmjd2c histone demethylase enhances the expression of Mdm2 oncogene. Ishimura A, Terashima M, Kimura H, Akagi K, Suzuki Y, Sugano S, Suzuki T. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 389 2 366-371 2009/11
  •  Cancer Sci. 2013 Jul;104(7):795-800 CANCER SCIENCE 104 7 795-800 2013/07
  •  KDM5B histone demethylase controls epithelial-mesenchymal transition of cancer cells by regulating the expression of the microRNA-200 family. Enkhbaatar Z,Terashima M,Oktyabri D,Tange S,Ishimura A,Yano S,Suzuki T Cell Cycle 12 13 2100-2012 2013/07

Conference Presentations

Arts and Fieldwork


Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「関連遺伝子Jmjd5の新しい遺伝子発現制御機構の解明 」(2013-2016) 
○「核膜内膜蛋白 Man1 による心臓の左右非対称性制御メカニズム」(2007-2008) 

Classes (Bachelors)

Classes (Graduate Schools)

○Tumor Virology(2017)
○Tumor Virology(2017)
○Tumor Virology(2016)
○Tumor Virology(2016)
○Seminar on Tumor Biology(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

To Page Top