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Researcher Information

last modified:2018/04/13

Professor KANEKO Shuichi

Mail

Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Environmental Science, Graduate School of Medical Scienc
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Disease Control and Homeostasis TEL:076-265-2233 FAX:076-234-4250

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor 198603 Completed
【Academic background(Bachelor's Degree)】
Kanazawa University 198203

Career

Kanazawa University(1986/04/01-1989/03/06)
NIH(1987/02/21-1989/03/06)
Kanazawa University(1992/07/01-1995/03/31)
*(1993/09/18-1995/03/31)
Kanazawa University(1996/04/01-2004/05/15)
(1989/03/06-1993/03/31)
Kanazawa University(2004/05/16-)

Year & Month of Birth

1956/08

Academic Society

The Japanese Society of Internal Medicine
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Specialities

、Experimental Pathology、Gastroenterology

Speciality Keywords

Experimental Pathology, Virology, Cancer, Liver

Research Themes

Cancer Research

Liver metabolism and systemic illness

Hepatitis Virus

Books

  •  Kitao A, Matsui O, Yoneda N, Kozaka K, Kobayashi S, Koda W, Gabata T, Yamashita T, Kaneko S, Nakanuma Y, Kita R, Arii S. Hypervascular Hepatocellular Carcinoma: Correlation between Biologic Features and Signal Intensity on Gadoxetic Acid-enhanced MR Images. 265 3 780-89 2012/12
  •  Y Marukawa, Y Nakamoto, K Kakinoki, T Tsuchiyama, N Iida, T Kagaya, Y Sakai, M Naito, N Mukaida, S Kaneko Membrane-bound form of monocyte chemoattractant protein-1 enhances antitumor effects of suicide gene therapy in a model of hepatocellular carcinoma. 19 312-19 2012/03
  •  Keisuke Ohtani, Soichiro Usui, Shuichi Kaneko, 他6名 Benidipine reduces ischemia reperfusion-induced systemic oxidative stress through suppression of aldosterone production in mice. 35 3 287-94 2012/03
  •  Taro Yamashita, Masao Honda, Shuichi Kaneko Heterogeneity of Liver Cancer Stem Cells 7 301-317 2011/11
  •  Yusuke Nakade, Toshinari Takamura, Masaru Sakurai, Hirofumi Misu, Mitsuko Nagata, Yuko Nanbu, Hiroyasu Oe, Toshiji Takamura, Yoshio Sakai, Shuichi Kaneko, Takashi Wada Malnutrition Impairs Interferon Signaling Through mTOR and FoxO Pathways in Patients With Chronic Hepatitis C 2 4 324-27 2011/08

Papers

  •  Telomerase maintains telomere structure in normal human cells. CELL 114 2 241-253 2003/07
  •  Prevention of hepatocellular carcinoma development associated with chronic hepatitis by anti-fas ligand antibody therapy JOURNAL OF EXPERIMENTAL MEDICINE 196 8 1105-1111 2002/10
  •  Identification of differentially expressed genes in hepatocellular carcinoma with cDNA microarrays HEPATOLOGY 33 4 832-840 2001/04
  •  Differential gene expression between chronic hepatitis B and C hepatic lesion GASTROENTEROLOGY 120 4 955-966 2001/03
  •  Histological feature predicting malignant transformation of nonmalignant hepatocellular nodules: a prosptective study GASTROENTEROLOGY 115 5 1216-1222 1998/10

show all

  •  La protein is a potent regulator of replication of hepatitis C virus in patients with chronic hepatitis C through internal ribosomal entry site (IRES) directed translation. 84 5 867-875 2005/02
  •  Different procarcinogenic potentials of lymphocyte subsets in a transgenic mouse model of chronic hepatitis B. 64 9 3326-3333 2004/05
  •  Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis. 132 1 282-293 2007/01
  •  Tumor cell apoptosis induces tumor-specific immunity in a CC chemokine receptor 1- and 5-dependent manner in mice N Iida, Y Nakamoto, T Baba, K Kakinoki, YY Li, Y Wu, K Matsushima, S Kaneko, and N Mukaida 84 4 1001-10 2008/10
  •  Expression of multidrug resistance-associated protein 3 and cytotoxic T cell responses in patients with hepatocellular carcinoma E Mizukoshi, M Honda, K Arai, T Yamashita, Y Nakamoto, and S Kaneko 49 6 946-54 2008/12
  •  Identification of novel candidate tumour marker genes for intrahepatic cholangiocarcinoma R Nishino, M Honda, H Takatori, H Minato, Y Zen, M Sasaki, H Takamura, K Horimoto, T Ohta, Y Nakanuma, and S Kaneko 49 2 207-16 2008/08
  •  Gastrobronchial fistula U Fuchizaki, T Machi, and S Kaenko 370 9601 1780 2007/11
  •  Hepatitis B virus X protein overcomes oncogenic RAS-induced senescence in human immortalized cells N Oishi, K Shilagardi, Y Nakamoto, M Honda, S Kaneko, and S Murakami 98 10 1540-8 2007/10
  •  Impact of diabetes on recurrence of hepatocellular carcinoma after surgical treatment in patients with viral hepatitis T Komura, E Mizukoshi, Y Kita, M Sakurai, Y Takata, K Arai, T Yamashita, T Ohta, K Shimizu, Y Nakamoto, M Honda, T Takamura, and S Kaneko 102 9 1939-46 2007/06
  •  Analysis of hepatitis C virus-specific CD8+ T-cells with HLA-A*24 tetramers during phlebotomy and interferon therapy for chronic hepatitis C K Kaji, Y Nakamoto, and S Kaneko 18 4 993-8 2007/10
  •  Human telomerase exists in two distinct active complexes in vivo H Mizuno, S Khurts, T Seki, Y Hirota, S Kaneko, and S Murakami 141 5 641-52 2007/03
  •  Intrahepatic interleukin-8 production during disease progression of chronic hepatitis C Y Tachibana, Y Nakamoto, N Mukaida, and S Kaneko 251 1 36-42 2007/01
  •  Expression profiling of peripheral-blood mononuclear cells from patients with chronic hepatitis C undergoing interferon therapy M Tateno, M Honda, T Kawamura, H Honda, and S Kaneko 195 2 255-67 2007/01
  •  Clinical challenges and images in GI. Yersinia enterocolitica mesenteric adenitis and terminal ileitis U Fuchizaki, T Machi, and S Kaneko 131 5 1379,1659 2006/11
  •  Different signaling pathways in the livers of patients with chronic hepatitis B or chronic hepatitis C M Honda, T Yamashita, T Ueda, H T, R Nishino, and S Kaneko 44 5 1122-38 2006/11
  •  Virological effects and safety of combined double filtration plasmapheresis (DFPP) and interferon therapy in patients with chronic hepatitis C: A preliminary study T Yamashita, K Arai, A Sakai, E Mizukoshi, Y Sakai, T Kagaya, Y Nakamoto, M Honda, T Wada, H Yokoyama, and S Kaneko Hepatol Res 36 3 167-75 2006/11
  •  Transgenic mice aberrantly expressing pyruvate dehydrogenase complex E2 component on biliary epithelial cells do not show primary biliary cirrhosis K Inamura, H Tsuji, Y Nakamoto, M Suzuki, and S Kaneko. 145 1 93-100 2006/07
  •  Analysis of intrahepatic lymphocyte subsets in a transgenic mouse model of immune-mediated hepatocarcinogenesis Y Nakamoto, and S Kaneko 25 1 55-7 2006/03
  •  Cytotoxic T cell responses to human telomerase reverse transcriptase in patients with hepatocellular carcinoma E Mizukoshi, Y Nakamoto, Y Marukawa, K Arai, T Yamashita, H Tsuji, K Kuzushima, M Takiguchi, and S Kaneko. 43 6 1284-94 2006/06
  •  The development and clinical features of splenic aneurysm associated with liver cirrhosis H Sunagozaka, H Tsuji, E Mizukoshi, K Arai, T Kagaya, T Yamashita, A Sakai, Y Nakamoto, M Honda, and S Kaneko 26 3 291-297 2006/04
  •  Effect of hepatitis C virus (HCV) NS5B-nucleolin interaction on HCV replication with HCV subgenomic replicon T Shimakami, M Honda, T Kusakawa, T Murata, K Shimotohno, S Kaneko, and S Murakami. 80 7 3332-40 2006/04
  •  Pure red cell aplasia associated with concomitant use of mycophenolate mofetil and ribavirin in post-transplant recurrent hepatitis C Y Hodo, H Tsuji, E Mizukoshi, T Yamashita, A Sakai, Y Nakamoto, M Honda, and S Kaneko 19 2 170-1 2006/02
  •  Monocyte chemoattractant protein-1 gene delivery enhances antitumor effects of herpes simplex virus thymidine kinase/ganciclovir system in a model of colon cancer T Kagaya, Y Nakamoto, Y Sakai, T Tsuchiyama, H Yagita, N Mukaida, and S Kaneko 13 4 357-66 2006/04
  •  Essential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocellular carcinoma progression X Yang, P Lu, C Fujii, Y Nakamoto, JL Gao, S Kaneko, PM Murphy, and N Mukaida 118 8 1869-76 2006/03
  •  Identification of alpha-fetoprotein-derived peptides recognized by cytotoxic T lymphocytes in HLA-A24+ patients with hepatocellular carcinoma E Mizukoshi, Y Nakamoto, H Tsuji, T Yamashita, and S Kaneko 118 5 1194-1204 2006/03
  •  Molecular functions and biological roles of hepatitis B virus x protein H Tang, N Oishi, S Kaneko, and S Murakami 97 10 977-83 2006/10
  •  cDNA microarray analysis of autoimmune hepatitis, primary biliary cirrhosis and consecutive disease manifestation. M Honda, H Kawai, Y Shirota, T Yamashita, T Takamura, and S Kaneko. 25 2 133-140 2005
  •  Auxiliary partial orthotopic liver transplantation with de novo autoimmune hepatitis in the allograft and leftover primary biliary cirrhosis in the native liver. H Tsuji, K Hiramatsu, H Minato, S Kaneko, and Y Nakanuma. 2005
  •  Differential gene expression profiles in stage I primary biliary cirrhosis. M Honda, H Kawai, Y Shirota, T Yamashita, and S Kaneko. 100 9 2019-2030 2005
  •  Image of the month. U Fuchizaki, H Ohta, and S Kaneko. 128 7 1773 2005
  •  Differential gene alteration among hepatoma cell lines demonstrated by cDNA microarray-based comparative genomic hybridization. K Kawaguchi, M Honda, T Yamashita, Y Shirota, and S Kaneko. 329/1 370-380 2005
  •  Ephrin-A1 expression contributes to the malignant characteristics of alpha-fetoprotein-producing hepatocellular carcinoma. H Iida, M Honda, H F. Kawai, T Yamashita, Y Shirota, B-C Wang, H Miao, and S Kaneko. 54 6 843-851 2005
  •  Interferon-gamma-mediated hepatocarcinogenesis in mice treated with diethylnitrosamine. M Matsuda, Y Nakamoto, S Suzuki, T Kurata, and S Kaneko. 85 5 655-663 2005
  •  La protein is a potent regulator of replication of hepatitis C virus in patients with chronic hepatitis C through internal ribosomal entry site (IRES) directed translation. M Honda, T Shimazaki, and S Kaneko. 128 2, 449-462 2005
  •  Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity N Matsuzawa-Nagata, T Takamura, H Ando, S Nakamura, S Kurita, H Misu, T Ota, M Yokoyama, M Honda, K Miyamoto, and S Kaneko 57 8 1071-7 2008/08
  •  Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis M Uno, S Kurita, H Misu, H Ando, T Ota, N Matsuzawa-Nagata, Y Kita, S Nabemoto, H Akahori, Y Zen, Y Nakanuma, S Kaneko, and T Takamura 48 1 109-18 2008/07
  •  IFN-inducible protein 10 (CXCL10) regulates tubular cell proliferation in renal ischemia-reperfusion injury K Furuichi, T Wada, S Kitajikma, T Toyama, T Okumura, A Hara, Hi Kawachi, F Shimizu, T Sugaya, N Mukaida, S Narumi, K Matsushima, and S Kaneko 109 1 c29-38 2008/06
  •  Intra-thyroid blood flow in Plummer's disease S Kurita, H Ando, S Kaneko, and T Takamura 47 11 1065-6 2008/06
  •  Olmesartan ameliorates a dietary rat model of non-alcoholic steatohepatitis through its pleiotropic effects S Kurita, T Takamura, T Ota, N Matsuzawa-Nagata, Y Kita, Masafumi Uno, Satoko Nabemoto, Kazuhide Ishikura, Hirofumi Misu, Hitoshi Ando, Yoh Zen, Yasuni Nakanuma, and Shuichi Kaneko 588 2-3 316-24 2008/07
  •  The renin-angiotensin system contributes to renal fibrosis through regulation of fibrocytes N Sakai, T Wada, K Matsushima, R Bucala, M Iwai, M Horiuchi, and S Kaneko 26 4 780-90 2008/04
  •  Altered interaction between plasminogen activator inhibitor type 1 activity and sympathetic nerve activity with aging K Otowa, M Takamura, H Murai, M Maruyama, M Nakano, T Ikeda, D Kobayashi, H Ootsuji, M Okajima, H Furushou, T Yuasa, S Takata and S Kaneko 72 3 458-62 2008/03
  •  Protein expression profile characteristic to hepatocellular carcinoma revealed by 2D-DIGE with supervised learning R Teramoto, H Minagawa, M Honda, K Miyazaki, Y Tabuse, K Kamijo, T Ueda, S Kaneko 1784 5 764-72 2008/05
  •  Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis BK Popivanova, K Kitamura, Y Wu, T Kondo, T Kagaya, S Kaneko, M Oshima, C Fujii, and N Mukaida 118 2  560-70 2008/02
  •  Reduced nitric oxide causes age-associated impairment of circadian rhythmicity T Kunieda, T Minamino, K Miura, T Katsuno K Tateno, H Miyauchi, S Kaneko, CA Bradfield, GA FitzGerald, and I Komuro 102 5 607-14 2008/03
  •  Gene systems network inferred from expression profiles in hepatocellular carcinogenesis by graphical gaussian model S Aburatani, F Sun, S Saito, M Honda, S Kaneko, and K Horimoto 47214 2007/07
  •  Fibrocytes: a new insight into kidney fibrosis T Wada, N Sakai, K Matsushima, S Kaneko 72 269-73 2007/08
  •  Cross talk of tumor necrosis factor-alpha and the renin-angiotensin system in tumor necrosis factor-alpha-induced plasminogen activator inhibitor-1 production from hepatocytes Y Takeshita, T Takamura, H Ando, E Hamaguchi, A Takazakura, N Matsuzawa-Nagata, and S Kaneko 579 1-3 426-32 2008/01
  •  Comparative proteomic and transcriptomic profiling of human hepatocellular carcinoma H Minagawa, M Honda, K Miyazaki, Y Tabuse, R Teramoto, T Yamashita, R Nishino, H Takatori, T Ueda, K Kamijo, and S Kaneko. 366 1 186-192 2008
  •  Microscopic polyangiitis with ocular nimanifestations as the initial presenting sign. A Hara, S Ohta, M Tanaka, K Saito, M Torisaki, Y Ishida, T Wada, and S Kaneko 344 4 308-310 2007/06
  •  Impact of diabetes mellitus on prognosis of patients infected with hepatitis C virus Y Kita, E Mizukoshi, T Takamura, M Sakurai, Y Takata, K Arai, T Yamashita, Y Nakamoto, and S Kaneko 56 12 1682-1288 2007/12
  •  Regulation of adiponectin receptor expression in human liver and a hepatocyte cell line A Shimizu, T Takamura, N Matsuzawa, S Nakamura, S Nabemoto, Y Takeshita, H Misu, S Kurita, M Sakurai, M Yokoyama, Y Zen, M Sasaki, Y Nakanuma, and S Kaneko 56 11 1478-85 2007/11
  •  Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet N Matsuzawa, T Takamura, S Kurita, H Misu, T Ota, H Ando, M Yokoyama, M Honda, Y Zen, Y Nakanuma, K Miyamoto, and S Kaneko 46 5  1392-1403 2007/11
  •  Blockade of IP-10/CXCR3 promotes progressive renal fibrosis I Nakaya, T Wada, K Furuichi, N Sakai, K Kitagawa, H Yokoyama, Y Ishida, T Kondo, T Sugaya, H Kawachi, F Shimizu, S Narumi, M Haino, C Gerard, K Matsushima, and S Kaneko 107 1 e12-21 2007/07
  •  Gene expression profiles in peripheral blood mononuclear cells reflect the pathophysiology of type 2 diabetes T Takamura, M Honda, Y Sakai, H Ando, A Shimizu, T Ota, M Sakurai, H Misu, S Kurita, N Matsuzawa-Nagata, M Uchikata, S Nakamura, R Matoba, M Tanino, K Matsubara, and S Kaneko 361 2 379-84 2007/07
  •  Possible role of alpha-cell insulin resistance in exaggerated glucagon responses to arginine in type 2 diabetes N Tsuchiyama, T Takamura, H Ando, M Sakurai, A Shimizu, K Kato, S Kurita, and S Kaneko 30 10 2583-87 2007/07
  •  Functional interaction of hepatitis C Virus NS5B with Nucleolin GAR domain T Kusakawa, T Shimakami, S Kaneko, K Yoshioka, and S Murakami 141 6 917-27 2007/06
  •  Liver steatosis, but not fibrosis, is associated with insulin resistance in nonalcoholic fatty liver disease M Sakurai, T Takamura, T Ota, H Ando, H Akahori, K Kaji, M Sasaki, Y Nakanuma, K Miura, and S Kaneko 42 4 312-317 2007/06
  •  Double filtration plasmapheresis and interferon combination therapy for chronic hepatitis C patients with genotype 1 and high viral load K Fujiwara, S Kaneko, S Kakumu, M Sata, S Hige, E Tomia, S Mochida, and The Virus Reduction Therapy Study Group 37 9 701-710 2007/08
  •  Reactive peripheral blood plasmacytosis in a patient with acute hepatitis A T Wada, H Maeba, Y Ikawa, Y Hashida, A Okumura, F Shibata, Y Tone, M Inoue, S Koizumi, H Takatori, Y Sakai, S Kaneko, and A Yachie 85 3 191-4 2007/04
  •  Selective estrogen receptor modulator raloxifene-associated aggravation of nonalcoholic steatohepatitis T Takamura, A Shimizu, H Ando, and S Kaneko 46 9 579-81 2007/05
  •  Effect of sevelamer hydrochloride on markers of bone turnover in Japanese dialysis patients with low biointact PTH levels Y Iwata, T Wada, H Yokoyama, T Tohyama, S Kitajima, T Okumura, A Hara, J Yamahana, I Nakaya, M Kobayashi, K Kitagawa, S Kokubo, K Yoshimoto, K Shimizu, N Sakai, K Furuichi, Y Koshino, S Takeda, K Takasawa, S Ohta, M Takaeda, C Takaeda, and S Kaneko 46 8 447-52 2007/04
  •  Pioglitazone in nonalcoholic steatohepatitis T Ota, T Takamura, and S Kaneko 356 10 1068 2007/04
  •  Infection of human hepatocyte chimeric mouse with genetically engineered hepatitis C virus and its susceptibility to interferon N Hiraga, M Imamura, M Tsuge, C Noguchi, S Takahashi, E Iwao, Y Fujimoto, H Abe, T Maekawa, H Ochi, C Tateno, K Yoshizato, A Sakai, Y Sakai, M Honda, S Kaneko, T Wakita, and K Chayama 581 10 1983-87 2007/05
  •  Induction of reactive oxygen species from isolated rat glomeruli by protein kinase C activation and TNF-alpha stimulation, and effects of a phosphodiesterase inhibitor N Koike, T Takamura, and S Kaneko 80 18 1721-1278 2007/04
  •  Association of the C825T polymorphism of the G-protein beta3 subunit gene with hypertension, obesity, hyperlipidemia, insulin resistance, diabetes, diabetic complications, and diabetic therapies among Japanese T Hayakawa, T Takamura, T Abe, and S Kaneko 56 1 44-48 2007/04
  •  Comment on: Nathan DM, Buse JB, Davidson MB et al. (2006) Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes T Takamura, A Shimizu, H Ando, and S Kaneko 50 1 229-330 2007/05
  •  Genes involved in oxidative phosphorylation are coordinately upregulated with fasting hyperglycaemia in livers of patients with type 2 diabetes H Misu, T Takamura, N Matsuzawa, A Shimizu, T Ota, M Sakurai, H Ando, K Arai, T Yamashita, M Honda, T Yamashita, and S Kaneko. 50 2 268-77 2007/02
  •  Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis T Ota, T Takamura, S Kurita, N Matsuzawa, Y Kita, M Uno, H Akahori, H Misu, M Sakurai, Y Zen, Y Nakanuma, and S Kaneko 132 1 282-93 2007/01
  •  Factors associated with improvement of fasting plasma glucose level by mealtime dosing of a rapid-acting insulin analog in type 2 diabetes T Takamura, M Sakurai, M Nakamura, A Shimizu, T Ota, H Misu, Y Takeshita, N Tsuchiyama, S Kurita, H Ando, and S Kaneko 75 3 278-84 2007/01
  •  Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway T Kunieda, T Minamino, J Nishi, K Tateno, T Oyama, T Katsuno, H Miyauchi, M Orimo, S Okada, M Takamura, T Nagai, S Kaneko, and Issei Komuro 114 9 953-60 2006/08
  •  Erythrocyte sorbitol level as a predictor of the efficacy of epalrestat treatment for diabetic peripheral polyneuropathy H Ando, T Takamura, Y Nagai, and S Kaneko 20 6 367-70 2006/11
  •  Tumor necrosis factor-alpha-induced production of plasminogen activator inhibitor 1 and its regulation by pioglitazone and cerivastatin in a nonmalignant human hepatocyte cell line Y Takeshita, T Takamura, E Hamaguchi, A Shimizu, T Ota, M Sakurai, and S Kaneko 55 11 1464-72 2006/11
  •  What are arrhythmogenic substrates in diabetic rat atria? T Kato, T Yamashita, A Sekiguchi, K Sagara, M Takamura, S Takata, S Kaneko, T Aizawa, and L-T Fu 17 8 890-94 2006/08
  •  Secondary lymphoid tissue chemokine (SLC/CCL21)/CCR7 signaling regulates fibrocytes in renal fibrosis N Sakai, T Wada, H Yokoyama, M Lipp, S Ueha, K Matsushima, and S Kaneko 103 38 14098-14103 2006/09
  •  TAK-603, an anti-inflammatory compound, reduces crescentic glomerulonephritis and preserves renal function in WKY rats J Yamahana, T Wada, K Furuichi, N Sakai, H Yokoyama, and S Kaneko 21 10 2736-44 2006/10
  •  Reduction in Chronic Allograft Nephropathy by Inhibition of p38 Mitogen-Activated Protein Kinase T Wada, H Azuma, K Furuichi, N Sakai, K Kitagawa, Y Iwata, K Matsushima, S Takahara, H Yokoyama, and S Kaneko. 26 4 319-25 2006/06
  •  Negative regulation of endothelial morphogenesis and angiogenesis by S1P(2) receptor I Inoki, N Takuwa, N Sugimoto, K Yoshioka, S Takata, S Kaneko, and Y Takuwa 346 1, 293-300 2006/07
  •  Blockade of VEGF accelerates proteinuria, via decrease in nephrin expression in rat crescentic glomerulonephritis A Hara, T Wada, K Furuichi, N Sakai, H Kawachi, F Shimizu, M Shibuya, K Matsuchima, H Yokoyama, K Egashira, and S Kaneko. 69 11 1986-1995 2006/06
  •  MCP-1/CCR2-dependent loop for fibrogenesis in human peripheral CD14-positive monocytes N Sakai, T Wada, K Furuichi, K Shimizu, S Kokubo, A Hara, J Yamahana, T Okumura, K Matsushima, H Yokoyama, and S Kaneko 79 3 555-63 2006/03
  •  Pancreatic exocrine and endocrine events occur concomitantly but independently during the course of fulminant type 1 diabetes T Kahara, T Takamura, M Sakurai, H Misu, R Usuda, T Hayakawa, Y Nishimura, Y Bando, T Nagaoka, Y Nagai, and S Kaneko 71 3 241-46 2006/03
  •  The activity of single muscle sympathetic vasoconstrictor nerve unit is affected by physiologic stress in humans H Murai, S Takata, M Maruyama, M Nakano, D Kobayashi, Otowa K, M Takamura, T Yuasa, S Sakagami, and S Kaneko 290 2 H853-60 2006/02
  •  Profile of rhythmic gene expression in the livers of obese diabetic KK-A(y) mice H Ando, Y Oshima, H Yanagihara, Y Hayashi, T Takamura, S Kaneko, and A Fujimura. 346 4 1297-1302 2006/08
  •  The Rho/Rho-kinase systems are involved in rapid pacing-induced changes of atrial refractory period in a canine model H Furusho, S Sakagami, M Takamura, K Kitano, T Abe, M Hirazawa, S Usui, M Okajima, T Saeki, M Maruyama, S Kaneko, and S Takata 22 3 167-73 2006/02
  •  Timing of interferon therapy and sources of infection in patients with acute hepatitis C. K Ogata, T Ide, R Kumashiro, H Kumada, H Yotsuyanagi, K Okita, Y Akahane, S Kaneko, H Tsubouchi, E Tanaka, H Moriwaki, S Nishiguchi, S Kakumu, M Mizokami, S Iino, and M Sata 34 1 35-40 2006/01
  •  Measurement of thyroid blood flow area as useful for diagnosing the cause of thyrotoxicosis. S Kurita, M Sakurai, Y Kita, T Ota, H Ando, S Kaneko, and T Takamura. 15 11 1249-1252 2005
  •  Pretreatment prediction of interferon-alfa efficacy in chronic hepatitis C patients. K Hayashida, A Daiba, A Sakai, T Tanaka, K Kaji, N Inaba, S Ando, N Kajiyama, H Terasaki, A Abe, M Ogasawara, M Kohara, M Harada, T Okanoue, S Ito, and S Kaneko. 3 12 1253-1259 2005
  •  Subacute thyroiditis developed in identical twins two years apart. E Hamaguchi, Y Nishimura, S Kaneko, and T Takamura. 52 5 559-562 2005
  •  Effect of pimobendan on cardiopulmonary baroreflex control of sympathetic nerve activity in healthy young men. M Maruyama, M Takamura, S Takata, H Murai, S Usui, H Furusho, S Sakagami, T Yuasa, A Shimakura, and S Kaneko. 122 1-2 100-106 2005
  •  Rhythmic mRNA expression of clock genes and adipocytokines in mouse visceral adipose tissue. H Ando, H Yanagihara, Y Hayashi, Y Obi, S Tsuruoka, T Takamura, S Kaneko, and A Fujimura. 146 12 5631-5636 2005
  •  Detection of autoantibody to aldolase B in sera from patients with troglitazone-induced liver dysfunction. R Maniratanachote, A Shibata, S Kaneko, I Yamamori, T Wakasugi, T Sawazaki, K Katoh, S Tokudome, M Nakajima, and T Yokoi. 216 1 15-23 2005
  •  Relationship between plasma hANP level and pretibial edema by pioglitazone treatment. T Kahara, T Takamura, T Misaki, M Sakurai, Y Takeshita, A Shimizu, and S Kaneko. 52 3 373-376 2005
  •  Tranilast prevents the progression of experimental diabetic nephropathy through suppression of enhanced extracellular matrix gene expression. H Akahori, T Ota, M Torita, H Ando, S Kaneko, and T Takamura. 314 2 514-521 2005
  •  Regulation of cholesterol 7alpha-hydroxylase mRNA expression in C57BL/6 mice fed an atherogenic diet. H Ando, S Tsuruoka, H Yamamoto, T Takamura, S Kaneko, and A Fujimura. 178 2 265-269 2005
  •  Methods of analysis for chemicals that disrupt cellular signaling pathways: risk assessment for potential endocrine disruptors. 93. Y Umezawa, T Ozawa, M Sato, H Inadera, S Kaneko, M Kunimoto, and S Hashimoto. 12 1  49-64 2005
  •  Doppler tissue analysis of atrial electromechanical coupling in paroxysmal atrial fibrillation. W Omi, H Nagai, M Takamura, S Okura, M Okajima, H Furusho, M Maruyama, S Sakagami, S Takata, and S Kaneko 18 1 39-44 2005
  •  Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines. C Fujii, Y Nakamoto, P Lu, K Tsuneyama, BK Popivanova, S Kaneko, and N Mukaida. 114 2 209-218 2005
  •  Genome-wide transcriptome mapping analysis identifies organ-specific gene expression patterns along human chromosomes. T Yamashita, M Honda, H Takatori, R Nishino, N Hoshino, and S Kaneko. 84 5  867-875 2004
  •  Pivotal roles of interleukin-6 in transmural inflammation in murine T cell transfer colitis. K Kitamura, Y Nakamoto, S Kaneko, and N Mukaida. 76 6 1111-1117 2004
  •  An open-label study of administration of EH0202, a health-food additive, to patients with chronic hepatitis C. K Kaji, S Yoshida, N Nagata, T Yamashita, E Mizukoshi, M Honda, Y Kojima, and S Kaneko. 39 9  873-878 2004
  •  Genes for systemic vascular complications are differentially expressed in the livers of type 2 diabetic patients. T Takamura, M Sakurai, T Ota, H Ando, M Honda, and S Kaneko. 47 4 638-647 2004
  •  Different procarcinogenic potentials of lymphocyte subsets in a transgenic mouse model of chronic hepatitis B. Y Nakamoto, T Suda, T Momoi, and S Kaneko. 64 9 3326-3333 2004
  •  Effect of interaction between hepatitis C virus NS5A and NS5B on hepatitis C virus RNA replication with the hepatitis C virus replicon. T Shimakami, M Hijikata, H Luo, Y Y Ma, S Kaneko, K Shimotohno, and S Murakami. 78 6 2738-2748 2004
  •  Blood lipid mediator sphingosine-1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Krupel-like factor 5. S Usui, N Sugimoto, N Takuwa, S Sakagami, S Takata, S Kaneko, and Y Takuwa. 279 13 12300-12311 2004
  •  A low-density cDNA microarray with a unique reference RNA: pattern recognition analysis for IFN efficacy prediction to HCV as a model. A Daiba, N Inaba, S Ando, N Kajiyama, H Yatsuhashi, H Terasaki, A Ito, M Ogasawara, A Abe, J Yoshioka, K Hayashida, S Kaneko, M Kohara, and S Ito. 315 4 1088-1096 2004
  •  Radiofrequency ablation for life-threatening ruptured hepatocellular carcinoma. U Fuchizaki, H Miyamori, S Kitagawa, and S Kaneko. 40 2 354-355 2004
  •  Effects of pravastatin on the expression of ATP-binding cassette transporter A1. H Ando, S Tsuruoka, H Yamamoto, T Takamura, S Kaneko, and A Fujimura. 311 1 420-425 2004
  •  Hereditary haemorrhagic telangiectasia (Rendu-Osler-Weber disease). U Fuchizaki, H Miyamori, S Kitagawa, S Kaneko, and K Kobayashi. 362 9394 1490-1494 2003
  •  Mechanisms of viral hepatitis induced liver injury. Y Nakamoto, and S Kaneko. Mechanisms of viral hepatitis induced liver injury. 3 6 537-544 2003
  •  Synergistic antiviral effect of a combination of mouse interferon-alpha and interferon-gamma on mouse hepatitis virus. U Fuchizaki, S Kaneko, Y Nakamoto, Y Sugiyama, K Imagawa, M Kikuchi, and K Kobayashi. 69 2 188-194 2003
  •  DNA alterations during multi-step development of human hepatocellular carcinomas revealed by laser capture microdissection. H Nagai, M Emi, Y Terada, M Baba, M Shimizu, N Konishi, S Kaneko, K Kobayashi, Y Yumoto, M Ghazizadeh, O Kawanami, K Matsubara. 26 3 199-208 2003
  •  Potential interaction between CCR1 and its ligand, CCL3, induced by endrogenously produced interleukin-1 in human hepatomas. P Lu, Y Nakamoto, Y Nemoto-Sasaki, C Fujii, H Wang, M Hayashi, Y Ohmoto, S Kaneko, K Kobayashi, and N Mukaida. 162 4 1249-1258 2003
  •  Telomerase maintains telomere structure in normal human cells. K Masutomi, E Y Yu, S Khurts, I Ben-Porath, J L Currier, G B Metz, M W Brooks, S Kaneko, S Murakami, J A DeCaprio, R A Weinberg, S A Stewart, and W C Hahn. 114 2 241-253 2003
  •  Clinical application of a DNA chip in the field of liver diseases. S Kaneko, and K Kobayashi. 38 Suppl XV 85-88 2003
  •  Enhanced anti-tumor effects of a bicistronic adenovirus vector expressing both herpes simplex virus thymidine kinase and monocyte chemoattractant ptotein-1 against hepatocellular carcinoma. T Tsuchiyama, S Kaneko, Y Nakamoto, Y Sakai, M Honda, N Mukaida, and K Kobayashi. 10 4 260-269 2003
  •  Detection of hepatitis B virus DNA in serum from patients with chronic hepatitis B using a DNA mircoarray method. K Kawaguchi, S Kaneko, M Honda, H Kawai, Y Shirota, and K Kobayashi. 41 4 1701-1704 2003
  •  Analysis of the CD8-positive T cell response in Japanese patients with chronic hepatitis C using HLA-A*2402 peptide tetramers. Y Nakamoto, S Kaneko, H Takizawa, Y Kikumoto, M Takano, Y Himeda, and K Kobayashi. 70 1 51-61 2003
  •  Analysis of the CD8-positive T cell response in Japanese patients with chronic hepatitis C using HLA-A*2402 peptide tetramers. Y Nakamoto, S Kaneko, H Takizawa, Y Kikumoto, M Takano, Y Himeda, and K Kobayashi. 70 1  51-61 2003
  •  Direct interaction between nucleolin and hepatitis C virus NS5B. M Hirano, S Kaneko, T Yamashita, H Lou, W Qin, Y Shirota, T Nomura, K Kobayashi, and S Murakami. 278 7  5109-5115 2003
  •  Apoptosis of murine cultured biliary epithelial cells induced by glycochenodeoxycholic acid involves Fas receptor and its ligand. M Iwata, K Harada, K Katayanagi, T Saito, S Kaneko, K Kobayashi, and Y Nakanuma. 25 3 329-342 2003
  •  Identification of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-responsive genes in mouse liver by serial analysis of gene expression. M Kurachi, S Hashimoto, A Obata, S Nagai, T Nagahata, H Inadera, H Sone, C Tohyama, S Kaneko, K Kobayashi, and K Matsushima. 292 2 368-377 2002
  •  Tiny staining spots liver cirrhosis associated with HCV infection observed by computed tomographic hepatic arteriography: follow-up study. T Tsuchiyama, STerasaki, S Kaneko, K Kaji, K Kobayashi, and O Matsui. 37 10 807-814 2002
  •  Pathogenic roles of tumor necrosis factor receptor p55-mediated signals in dimethylnitrosamine-induced murine liver fibrosis. K Kitamura, Y Nakamoto, M Akiyama, C Fujii, T Kondo, K Kobayashi, S Kaneko, and N Mukaida. 82 2 571-583 2002
  •  Prevention of hepatocellular carcinoma development associated with chronic hepatitis by anti-fas ligand antibody therapy. Y Nakamoto, S Kaneko, H Fan, T Momoi, H Tsutsui, K Nakanichi, K Kobayashi, and T Suda. 196 8 1105-1111 2002
  •  BMI, Waist Circumference, and Metabolic Syndrome: Lessons from Japanese Perspectives Masaru Sakurai, Tsuguhito Ota, Katsuyuki Miura, Hideaki Nakagawa, Shuichi Kaneko, Toshinari Takamura 1973-88 2012/02
  •  The role of cytokine in the lupus nephritis. Iwata Y, Furuichi K, Kaneko S, Wada T. 2012/12
  •  Identification of Aldo-Keto Reductase 1C3-Derived Peptides Recognized by Cytotoxic T cells in Hepatocellular Carcinoma Patients. Eishiro Mizukoshi, Masao Honda, Kazumi Fushimi, Kuniaki Arai, Tatsuya Yamashita, Shuichi Kaneko. 1 1 47-57 2012/07
  •  Prospects of Immunotherapy for Hepatocellular Carcinoma.  Eishiro Mizukoshi, Shuichi Kaneko 1 69-71 2012/12
  •  Magnetic resonance imaging in a patient with an implantable cardiac defibrillator Hiroshi Furusho, Takashi Kusayama, Akio Chikata, Daisuke Kobayashi, Hisayoshi Murai, Soichiro Usui, Masaki Okajima, Shuichi Kaneko, Masakazu Yamagishi, Masayuki Takamura 28 6 353-55 2012/12
  •  Discrete nature of EpCAM(+) and CD90(+) cancer stem cells in human hepatocellular carcinoma. Yamashita T, Honda M, Nakamoto Y, Baba M, Nio K, Hara Y, Zeng SS, Kondo TH, Takatori H, Yamashita T, Mizukoshi E, Ikeda H, Zen Y, Takamura H, Wang XW, Kaneko S 2012/11
  •  Nucleostemin in Injury-Induced Liver Regeneration. Haruhiko Shugo, Takako Ooshio, Masako Naito, Kazuhito Naka, Takayuki Hoshii, Yuko Tadokoro, Teruyuki Muraguchi, Akira Tamase, Noriyuki Uema, Taro Yamashita, Yasunari Nakamoto, Toshio Suda, Shuichi Kaneko, Atsushi Hirao 21 16 3044-54 2012/11
  •  Expression of chondroitin-glucuronate C5-epimerase and cellular immune responses in patients with hepatocellular carcinoma. Mizukoshi E, Fushimi K, Arai K, Yamashita T, Honda M, Kaneko S 32 10 1516-26 2012/11
  •  Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma. Oishi N, Kumar MR, Roessler S, Ji J, Forgues M, Budhu A, Zhao X, Andersen JB, Ye QH, Jia HL, Qin LX, Yamashita T, Woo HG, Kim YJ, Kaneko S, Tang ZY, Thorgeirsson SS, Wang XW 56 5 1792-1803 2012/11
  •  Association of changes in the gene expression profile of blood cells with the local tumor inflammatory response in a murine tumor model. Sakai Y, Tatsumi I, Higashimoto M, Seki A, Nasti A, Yoshida K, Kawaguchi K, Wada T, Honda M, Komura T, Kaneko S.  428 1 36-43 2012/11
  •  Genome-wide Association Study Identifies TNFSF15 and POU2AF1 as Susceptibility Loci for Primary Biliary Cirrhosis in the Japanese Population. Minoru Nakamura, Nao Nishida, Minae Kawashima, Yoshihiro Aiba, Atsushi Tanaka, Michio Yasunami, Hitomi Nakamura, Atsumasai Komori, Makoto Nakamuta, Mikio Zeniya, Etsuko Hashimoto, Hiromasa Ohira, Kazuhide Yamamoto, Morikazu Onji, Shuichi Kaneko,  他65名 91 4 721-28 2012/10
  •  Effects of adipose-derived mesenchymal cells on ischemia-reperfusion injury in kidney.  Furuichi K, Shintani H, Sakai Y, Ochiya T, Matsushima K, Kaneko S, Wada T. 16 5 679-89 2012/10
  •  Fatty liver as a consequence and cause of insulin resistance: Lessons from type 2 diabetic liver [Review]. Yamashita T, Arai K, Terashima T, Sunagozaka H, Shimakami T, Yamashita T,Mizukoshi E, Sakai A, Honda M, Kaneko S. 59 9 745-63 2012/09
  •  A case report of S-1 monotherapy foradvanced hepatocellular carcinoma.9 Kita Y, Takamura T, Misu H, Ota T, Kurita S, Takeshita Y, Uno M, Matsuzawa-Nagata N, Kato K, Ando H, Fujimura A, Hayashi K, Kimura T, Ni Y, Otoda T, Miyamoto K, Zen Y, Nakanuma Y, Kaneko S. 39 9 1435-37 2012/09
  •  Duodenal adenocarcinoma with neuroendocrine features in a patient with acromegaly and thyroid papillary adenocarcinoma: an unique combination of endocrine neoplasia. Ken-ichiro Kato, Yumie Takeshita, Hirofumi Misu, Kazuhide Ishikura, Kaheita Kakinoki, Seiko Sawada-Kitamura, Shuichi Kaneko, Toshinari Takamura 59 9 791-96 2012/09
  •  Acyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinoma development. Okada H, Honda M, Campbell JS, Sakai Y, Yamashita T, Takebuchi Y, Hada K, Shirasaki T, Takabatake R, Nakamura M, Sunagozaka H, Tanaka T, Fausto N, Kaneko S. 72 17 4459-71 2012/09
  •  Metformin prevents and reverses inflammation in a non-diabetic mouse model of nonalcoholic steatohepatitis. Kita Y, Takamura T, Misu H, Ota T, Kurita S, Takeshita Y, Uno M, Matsuzawa-Nagata N, Kato K, Ando H, Fujimura A, Hayashi K, Kimura T, Ni Y, Otoda T, Miyamoto K, Zen Y, Nakanuma Y, Kaneko S. 7 9 2012/09
  •  Three cases of pneumatosis intestinalis presenting in autoimmune diseases. Sagara A, Kitagawa K, Furuichi K, Kitajima S, Toyama T, Okumura T, Hara A, Sakai Y, Kaneko S, Wada T. 22 4 610-15 2012/08
  •  Comparison of chemotherapeutic treatment outcomes of advanced extrapulmonary neuroendocrine carcinomas and advanced small-cell lung carcinoma.  Terashima T, Morizane C, Hiraoka N, Tsuda H, Tamura T, Shimada Y, Kaneko S, Kushima R, Ueno H, Kondo S, Ikeda M, Okusaka T 96 4 324-32 2012/08
  •  Heterogeneous nuclear ribonucleoprotein A2/B1 in association with hTERT is a potential biomarker for hepatocellular carcinoma. Hideki Mizuno, Masao Honda, Takayoshi Shirasaki, Taro Yamashita, Tatsuya Yamashita, Eishiro Mizukoshi, Shuichi Kaneko 32 7 1146-55 2012/08
  •  CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status. Hironori Kitade, Kazuki Sawamoto, Mayumi Nagashimada, Hiroshi Inoue, Yasuhiko Yamamoto, Yoshimichi Sai, Toshinari Takamura, Hiroshi Yamamoto, Ken-ichi Miyamoto, Henry N. Ginsberg, Naofumi Mukaida, Shuichi Kaneko, Tsuguhito Ota 61 1680-90 2012/07
  •  No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations. Nakamura S, Kawai K, Takeshita Y, Honda M, Takamura T, Kaneko S, Matoba R, Matsubara K.  2012/06
  •  Genome-Wide Association Study Confirming Association of HLA-DP with Protection against Chronic Hepatitis B and Viral Clearance in Japanese and Korean. Nishida N, Sawai H, Matsuura K, Sugiyama M, Ahn SH, Park JY, Hige S, Kang JH, Suzuki K, Kurosaki M, Asahina Y, Mochida S, Watanabe M, Tanaka E, Honda M, Kaneko S, 他20名 7 6 2012/06
  •  Guideline on the use of new anticancer drugs for the treatment of Hepatocellular Carcinoma 2010 update. Kaneko S, Furuse J, Kudo M, Ikeda K, Honda M, Nakamoto Y, 他14名 42 6 523-42 2012/06
  •  Pharmacokinetics and pharmacodynamics of insulin aspart in patients with Type 2 diabetes: Assessment using a meal tolerance test under clinical conditions. Hitoshi Ando, Seiichiro Kurita, Akiko Shimizu, Ken-ichiro Kato, Kazuhide Ishikura, Koumei Taji, Masafumi Uno, Yumie Takeshita, Hirofumi Misu, Akio Fujimura, Shuichi Kaneko, Toshinari Takamura 39 6 528-34 2012/05
  •  Advantage of recording single-unit muscle sympathetic nerve activity in heart failure. Hisayoshi Murai, Masayuki Takamura, Shuichi Kaneko 3 109 2012/05
  •  Beneficial effect of branched-chain amino acid supplementation on glycemic control in chronic hepatitis C patients with insulin resistance: Implications for type 2 diabetes. Yumie Takeshita, Toshinari Takamura, Yuki Kita, Hitoshi Ando, Teruyuki Ueda, Kenichiro Kato, Hirofumi Misu, Hajime Sunagozaka, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko 61 10 1388-94 2012/04
  •  Synthesis, Structure, and Physiological Effects of Peroxovanadium(V) Complexes Containing Amino Acid Derivatives as Ancillary Ligands Hironori Sugiyama, Seiichi Matsugo, Tetsuya Konishi, Toshinari Takamura, Shuichi Kaneko, Yukari Kubo, Kyouhei Sato, Kan Kanamori* 41 4 377-79 2012/04
  •  Inverse Correlation between Serum Levels of Selenoprotein P and Adiponectin in Patients with Type 2 Diabetes. Hirofumi Misu, Kazuhide Ishikura, Seiichiro Kurita, Yumie Takeshita, Tsuguhito Ota, Yoshiro Saito, Kazuhiko Takahashi, Shuichi Kaneko, Toshinari Takamura 7 4 2012/04
  •  Coexpression network analysis in chronic hepatitis B and C hepatic lesion reveals distinct patterns of disease progression to hepatocellular carcinoma. Danning He, Zhi-Ping Liu, Masao Honda, Shuichi Kaneko, Luonan Chen 2012/03
  •  Effects of adipose-derived mesenchymal cells on ischemia-reperfusion injury in kidney. Kengo Furuichi, Hidemi Shintani, Yoshio Sakai, Takahiro Ochiya, Kouji Matsushima, Shuichi Kaneko, Takashi Wada 19 312-19 2012/03
  •  Mesenchymal stem cell therapy on murine model of nonalcoholic steatohepatitis. Yoshio Sakai, Shuichi Kaneko 826 5 217-23 2012/03
  •  Induction of elastin expression in vascular endothelial cells relates to hepatoportal sclerosis in idiopathic portal hypertension: possible link to serum anti-endothelial cell antibodies. Sato Y, Ren XS, Harada K, Sasaki M, Morikawa H, Shiomi S, Honda M, Kaneko S, Nakanuma Y. 167 3 532-42 2012/03
  •  Identification of blood biomarkers of aging by transcript profiling of whole blood. Seiji Nakamura, Kozo Kawai, Yumie Takeshita, Masao Honda, Toshinari Takamura, Shuichi Kaneko, Ryo Matoba, Kenichi Matsubara 418 2 313-318 2012/02
  •  Fas Ligand Has a Greater Impact than TNF-α on Apoptosis and Inflammation in Ischemic Acute Kidney Injury  Kengo Furuichi, Satoshi Kokubo, Akinori Hara, Ryu Imamura, Qiang Wang, Shinji Kitajima, Tadashi Toyama, Toshiya Okumura, Kouji Matsushima, Takashi Suda, Naofumi Mukaida, Shuichi Kaneko, Takashi Wada 2 1 27-38 2012/02
  •  Clinical impact of albuminuria in diabetic nephropathy. Wada T, Shimizu M, Toyama T, Hara A, Kaneko S, Furuichi K 16 1 96-101 2012/02
  •  Possible Influence of Ileal Neobladder on Assessment of Urinary C-peptide. TAKAHIRO ZENDA, MASAJI MIYAMOTO, TOSHIMITSU MISAKI, SHUICHI KANEKO 35 2 8- 2012/02
  •  Augmented single-unit muscle sympathetic nerve activity in heart failure with chronic atrial fibrillation Tatsunori Ikeda, Hisayoshi Murai, Shuichi Kaneko, 他9名 590 3 509-17 2012/02
  •  Slowly Progressive Insulin-Dependent Diabetes in a Patient with Primary Biliary Cirrhosis with Portal Hypertension-Type Progression Yumie Takeshita, Toshinari Takamura, Oto Inoue, Miki Okumura, Kenichiro Kato, Hajime Sunagozaka, Kuniaki Arai, Hirofumi Misu, Minoru Nakamura, Yasuni Nakanuma and Shuichi Kaneko 51 1 79-82 2012/01
  •  Dietary glycemic index and risk of type 2 diabetes mellitus in middle-aged Japanese men. Sakurai M, Nakamura K, Miura K, Takamura T, Yoshita K, Morikawa Y, Ishizaki M, Kido T, Naruse Y, Suwazono Y, Kaneko S, Sasaki S, Nakagawa  61 1 47-55 2012/01
  •  Activation of p38 mitogen-activated protein kinase promotes peritoneal fibrosis by regulating fibrocytes. Satoshi Kokubo, Norihiko Sakai, Kengo Furuichi, Tadashi Toyama, Shinji Kitajima, Toshiya Okumura, Kouji Matsushima, Shuichi Kaneko, Takashi Wada 32 1 10-19 2012/01
  •  Randomized, Phase II Study Comparing Interferon Combined with Hepatic Arterial Infusion of Fluorouracil plus Cisplatin and Fluorouracil Alone in Patients with Advanced Hepatocellular Carcinoma. Yamashita T, Arai K, Sunagozaka H, Ueda T, Terashima T, Yamashita T, Mizukoshi E, Sakai A, Nakamoto Y, Honda M, Kaneko S. 81 56 281-90 2011/11
  •  Concentration-dependent Dual Effects of Hydrogen Peroxide on Insulin Signal Transduction in H4IIEC Hepatocytes Satoshi Iwakami, Hirofumi Misu, Takashi Takeda, Makoto Sugimori, Seiichi Matsugo, Shuichi Kaneko, Toshinari Takamura 6 11 1-11 2011/11
  •  Identification of a secretory protein c19orf10 activated in hepatocellular carcinoma. Hajime Sunagozaka, Masao Honda, Taro Yamashita, Ryuhei Nishino, Hajime Takatori, Kuniaki Arai, Tatsuya Yamashita, Yoshio Sakai, Shuichi Kaneko 129 1576-85 2011/10
  •  The uptake transporter OATP8 expression decreases during multistep hepatocarcinogenesis: correlation with gadoxetic acid enhanced MR imaging Azusa Kitao, Osamu Matsui, Norihide Yoneda, Kazuto Kozaka, Rieko Shinmura, Wataru Koda, Satoshi Kobayashi, Toshifumi Gabata, Yoh Zen, Tatsuya Yamashita, Shuichi Kaneko, Yasuni Nakanuma 21 10 2056-66 2011/10
  •  Cytokines and chemokines as therapeutic targets for ischemic kidney injury Furuichi K, Wada T, Kaneko S 31 4 365-69 2011/09
  •  Angiotensin II type 1 receptor blocker attenuates diabetes-induced atrial structural remodeling. Takeshi Kato, Takeshi Yamashita, Akiko Sekiguchi, Takayuki Tsuneda, Kouichi Sagara, Masayuki Takamura, Shuichi Kaneko, Tadanori Aizawa, Long-Tai Fu 58 2 131-36 2011/09
  •  Characterization of naturally occurring protease inhibitor-resistance mutations in genotype 1b hepatitis C virus patients. Hiroko Shindo, Shinya Maekawa, Kazuki Komase, Ryota Sueki, Mika Miura, Makoto Kadokura, Kuniaki Shindo, Fumitake Amemiya, Takatoshi Kitamura, Yasuhiro Nakayama, Taisuke Inoue, Minoru Sakamoto, Shun-ichi Okada, Yasuhiro Asahina, Namiki Izumi, Masao Honda, Shuichi Kaneko, Nobuyuki Enomoto 6 482-90 2011/08
  •  Frequency of CD45RO+ subset in CD4+CD25high regulatory T cells associated with progression of hepatocellular carcinoma. Yoshiko Takata, Yasunari Nakamotoa, Akiko Nakadab, Takeshi Terashimaa, Fumitaka Ariharaa, Masaaki Kitaharaa, Kaheita Kakinokia, Kuniaki Araia, Taro Yamashitaa, Yoshio Sakaia, Tatsuya Yamashitaa, Eishiro Mizukoshia, Shuichi Kaneko 307 2 165-73 2011/08
  •  Differentiation of Cancer Stem Cells Taro Yamashita, Masao Honda, Shuichi Kaneko 337-350 2011/08
  •  Malnutrition Impairs Interferon Signaling Through mTOR and FoxO Pathways in Patients With Chronic Hepatitis C Masao Honda, Kenji Takehana, Akito Sakai, Yusuke Tagata, Takayoshi Shirasaki, Shinobu Nishitani, Takahiko Muramatsu, Tatsuya Yamashita, Yasunari Nakamoto, Eishiro Mizukoshi, Yoshio Sakai, Taro Yamashita, Mikiko Nakamura, Tetsuro Shimakami, MinKyung Yi, Stanley M. Lemon, Tetsuo Suzuki, Takaji Wakita, Shuichi Kaneko 141 1 128-140 2011/07
  •  Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C. Yasuhito Tanaka, Masayuki Kurosaki, Nao Nishida, Masaya Sugiyama, Kentaro Matsuura, Naoya Sakamoto, Nobuyuki Enomoto, Hiroshi Yatsuhashi, Shuhei Nishiguchi, Keisuke Hino, Shuhei Hige, Yoshito Itoh, Eiji Tanaka, Satoshi Mochida, Masao Honda, Yoichi Hiasa, Asako Koike, Fuminaka Sugauchi, Shuichi Kaneko, 他3名 20 17 3507-16 2011/06
  •  Norovirus Gastroenteritis Accompanied by Marked Elevation of Transaminases Takahiro Zenda, Masaji Miyamoto, Shuichi Kaneko 60 2 41-43 2011/06
  •  Fractalkine and its receptor, CX3CR1, promote hypertensive interstitial fibrosis in the kidney. Shimizu K, Furuichi K, Sakai N, Kitagawa K, Matsushima K, Mukaida N, Kaneko S, Wada T 34 747-52 2011/06
  •  Insulin resistance caused by a redox-associated hepatokine Toshinari Takamura, Hirofumi Misu, Shuichi Kaneko 1 3 255-57 2011/05
  •  Comparative analysis of various tumor-associated antigen-specific t-cell responses in patients with hepatocellular carcinoma Eishiro Mizukoshi, Yasunari Nakamoto, Kuniaki Arai, Tatsuya Yamashita, Akito Sakai, Yoshio Sakai, Takashi Kagaya, Taro Yamashita, Masao Honda, Shuichi Kaneko 53 4 1206-16 2011/04
  •  Molecular mechanisms of hepatocarcinogenesis in chronic hepatitis C virus infection Taro Yamashita, Masao Honda, Shuichi Kaneko 26 960-64 2011/03
  •  Matrix metalloproteinase-2 (MMP-2) and membrane-type 1 MMP (MT1-MMP) affect the remodeling of glomerulosclerosis in diabetic OLETF rats. Kengo Furuichi, Yukimasa Hisada, Miho Shimizu, Toshiya Okumura, Kiyoki Kitagawa, Keiichi Yoshimoto, Yasunori Iwata, Hitoshi Yokoyama, Shuichi Kaneko and Takashi Wada 1-8 2011/03
  •  Pre-treatment prediction of response to pegylated-interferon plus ribavirin for chronic hepatitis C using genetic polymorphism in IL28B and viral factors Masayuki Kurosaki, Yasuhito Tanaka, Nao Nishida, Naoya Sakamoto, Nobuyuki Enomoto, Masao Honda, Masaya Sugiyama, Kentaro Matsuura, Fuminaka Sugauchi, Yasuhiro Asahina, Mina Nakagawa, Mamoru Watanabe, Minoru Sakamoto, Shinya Maekawa, Akito Sakai, Shuichi Kaneko 他5名 54 3 439-48 2011/03
  •  Involvement of bone-marrow-derived cells in kidney fibrosis Takashi Wada, Norihiko Sakai, Yoshio Sakai, Kouji Matsushima, Shuichi Kaneko, Kengo Furuichi 15 1 8-13 2011/02
  •  Involvement of inflammation in autoinflammation and autoimmune disease Kengo Furuichi, Takashi Wada, Shuichi Kaneko 31 1 81-87 2011/01
  •  Interleukin-1-dependent sequential chemokine expression and inflammatory cell infiltration in ischemia-reperfusion injury 34 9 2447-55 2006/09
  •  Combined therapy of transcatheter hepatic arterial embolization with intratumoral dendritic cell infusion for hepatocellular carcinoma; clinical safety 147 2 296-305 2007/02
  •  Prolonged, NK cell-mediated antitumor effects of suicide gene therapy combined with monocyte chemoattractant protein-1 against hepatocellular carcinoma 178 1 574-83 2007/01
  •  Comment on: Nathan DM, Buse JB, Davidson MB et al. (2006) Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes 50 1 229-30 2007/01
  •  Association of the C825T polymorphism of the G-protein β3 subunit gene with hypertension, obesity, hyperlipidemia, insulin resistance, diabetes, diabetic complications, and diabetic therapies among Japanese 56 1 44-8 2007/01
  •  Liver steatosis, but not fibrosis, is associated with insulin resistance in nonalcoholic fatty liver disease 42 4 312-7 2007/06
  •  Microscopic polyangiitis with ocular manifestations as the initial presenting sign 344 4 308-10 2007/10
  •   Fibrocyte: New participant in the pathogenesis of renal fibrosis 28 1 20-6 2008/04
  •   Development of evidence-based clinical guidelines for the diagnosis and treatment of hepatocellular carcinoma in Japan 38 1 37-51 2008/01
  •  Comparative proteomic and transcriptomic profiling of the human hepatocellular carcinoma 36 1 186-92 2008/02
  •  BMI may be better than waist circumference for defining metabolic syndrome in Japanese women 31 3 e12 2008/03
  •   Protein expression profile characteristic to hepatocellular carcinoma revealed by 2D-DIGE with supervised learning 19 4 415-20 2008/04
  •  Combined pure red cell aplasia and autoimmune hemolytic anemia in systemic lupus erythematosus with anti-erythropoietin autoantibodies 83 9 750-2 2008/09
  •  The attitudes of Japanese high school students toward cardiopulmonary resuscitation 78 3 340-55 2008/09
  •  Optimal amount of monocyte chemoattractant protein-1 enhances antitumor effects of suiside gene therapy against hepatocelluar carcinoma by M1 macrophage activation 99 10 2075-82 2008/10
  •   SAGE application in the study of diabetes 9 5 392-9 2008/10
  •  Application of serial analysis of gene expression in cancer research 9 5 375-82 2008/10
  •  Transformation of p53-positive papillary thyroid carcinoma to anaplastic carcinoma of the liver following postoperative radioactive iodine-131 therapy Y Takeshita, T Takamura, H Minato, H Misu, H Ando, T Yamashita, H Ikeda, Y Nakanuma, S Kaneko 49 19 1709-12 2008/10
  •  Comparative analysis of proteome and transcriptome in human hepatocellular carcinoma using 2D-DIGE and SAGE 27 7-8 401-19 2008/12
  •  Current status of anticoagulation therapy for elderly atrial fibrillation patients in Japan 72 12 2058-61 2008/12
  •   Obesity upregulates genes involved in oxidative phosphorylation in livers of diabetic patients T Takamura, H Misu, N Matsuzawa-Nagata, M Sakurai, T Ota, A Shimizu, S Kurita, Y Takeshita, H Ando, M Honda, S Kaneko 16 12 2601-09 2008/12
  •  Common transcriptional signature of tumor-infiltrating mononuclear inflammatory cells and peripheral blood mononuclear cells in hepatocellular carcinoma patients Y Sakai, M Honda, H Fujinaga, I Tatsumi, E Mizukoshi, Y Nakamoto, and S Kaneko 68 24 10267-79 2008/12
  •  Prevention of intrahepatic metastasis of liver cancer by suicide gene therapy and chemokine ligand 2/monocyte chemoattractant protein-1 delivery in mice K Kakinoki, Y Nakamoto, T Kagaya, T Tsuchiyama, Y Sakai, T Nakahama, N Mukaida, S Kaneko 12 12 1002-13 2010/12
  •  Graves' disease associated with infectious mononucleosis due to primary Epstein-Barr virus infection: report of 3 cases H Akahori, Y Takeshita, R Saito, S Kaneko, T Takamura 49 23 2599-603 2010/12
  •  Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma T Yamashita, M Honda, H Takatori, R Nishino, H Minato, H Takamura, T Ohta, and S Kaneko 50 1 100-10 2009/01
  •  Chemokine/chemokine receptor-mediated inflammation regulates pathologic changes from acute kidney injury to chronic kidney disease K Furuichi, S Kaneko, T Wada 13 1 9-14 2009/02
  •  Dendritic cells contribute to autoimmune kidney injury in MRL-Faslpr mice Y Iwata, K Furuichi, N Sakai, H Yamauchi, Y Shinozaki, H Zhou, Y Kurokawa, T Toyama, S Kitajima, T Okumura, S Yamada, I Maruyama, K Matsushima, S Kaneko, T Wada 36 2 306-14 2009/02
  •  Clock gene expression in peripheral leucocytes of patients with type 2 diabetes H Ando, T Takamura, N Matsuzawa-Nagata, KR Shima, T Eto, H Misu, M Shiramoto, T Tsuru, S Irie, A Fujimura, and S Kaneko 52 2 329-35 2009/02
  •  Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma S Ura, M Honda, T Yamashita, T Ueda, H Takatori, R Nishino, H Sunakozaka, Y Sakai, K Horimoto, and S Kaneko 49 4 1098-112 2009/04
  •  Middle-aged Japanese women are resistant to obesity-related metabolic abnormalities M Sakurai, T Takamura, K Miura, S Kaneko, H Nakagawa 58 4 456-9 2009/04
  •  EpCAM-Positive Hepatocellular Carcinoma Cells Are Tumor-Initiating Cells With Stem/Progenitor Cell Features T Yamashita, J Ji, A Budhu, M Forgues, W Yang, HY Wang, H Jia, Q Ye, LX Qin, E Wauthier, LM Reid, H Minato, M Honda, S Kaneko, ZY Tang, XW Wang 136 3 1012-24 2009/03
  •  The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis H Ando, T Takamura, N Matsuzawa-Nagata, KR Shima, S Nakamura, M Kumazaki, S Kurita, H Misu, N Togawa, T Fukushima, A Fujimura, S Kaneko 380 3 684-8 2009/03
  •  Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria S Nakamura, T Takamura, N Matsuzawa-Nagata, H Takayama, H Misu, H Noda, S Nabemoto, S Kurita, T Ota, H Ando, K Miyamoto, S Kaneko 284 22 14809-18 2009/05
  •  J-shaped relationship between waist circumference and subsequent risk for Type 2 diabetes: an 8-year follow-up of relatively lean Japanese individuals M Sakurai, K Miura, T Takamura, M Ishizaki, Y Morikawa, K Nakamura, K Yoshita, T Kido, Y Naruse, S Kaneko, H Nakagawa 26 8 753-9 2009/08
  •  S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species N Takuwa, SI Ohkura, SI Takashima, K Ohtani, Y Okamoto, T Tanaka, K Hirano, S Usui, F Wang, W Du, K Yoshioka, Y Banno, M Sasaki, I Ichi, M Okamura, N Sugimoto, K Mizugishi, Y Nakanuma, I Ishii, M Takamura, S Kaneko, S Kojo, K Satouchi, K Mitumori, J Chun, Y Takuwa 85 3 484-93 2010/02
  •  The histological course of nonalcoholic fatty liver disease in Japanese patients: Tight glycemic control, rather than weight reduction, ameliorates liver fibrosis E Hamaguchi, T Takamura, M Sakurai, E Mizukoshi, Y Zen, Y Takeshita, S Kurita, K Arai, T Yamashita, M Sasaki, Y Nakanuma, S Kaneko 33 2 284-6 2010/02
  •  Altered hepatic gene expression profiles associated with myocardial ischemia H Ootsuji, M Honda, S Kaneko, S Usui, M Okajima, H Okada, Y Sakai, T Takamura, K Horimoto, M Takamura 3 1 68-77 2010/02
  •  CD14+monocytes are vulnerable and functionally impaired under ER stress in patients with type 2 diabetes T Komura, Y Sakai, M Honda, T Takamura, K Matsushima, S Kaneko 59 3 634-43 2010/03
  •  dUTP pyrophosphatase expression correlates with a poor prognosis in hepatocellular carcinoma H Takatori, T Yamashita, M Honda, R Nishino, K Arai, T Yamashita, H Takamura, T Ohta, Y Zen, S Kaneko 30 3 438-46 2010/03
  •  Comprehensive gene expression analysis of 5'-end of mRNA identified novel intronic transcripts associated with hepatocellular carcinoma Y Hodo, SI Hashimoto, M Honda, T Yamashita, Y Suzuki, S Sugano, S Kaneko, K Matsushima 95 4 217-23 2010/04
  •  Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver Y Wu, Y Y Wang, Y Nakamoto, Y-Y Li, T Baba, S Kaneko, C Fujii, N Mukaida 29 15 2228-37 2010/04
  •  Enhancement of tumor-specific T cell responses by transcatheter arterial embolization with dendritic cell infusion for hepatocellular carcinoma E Mizukoshi, Y Nakamoto, K Arai, T Yamashita, N Mukaida, K Matsushima, O Matsui, S Kaneko 126 9 2164-74 2010/05
  •  Gene Knockout and Metabolome Analysis of Carnitine/Organic Cation Transporter OCTN1 Y Kato, Y Kubo, D Iwata, S Kato, T Sudo, T Sugiura, T Kagaya, T Wakayama, A Hirayama, M Sugimoto, K Sugihara, S Kaneko, T Soga, M Asano, M Tomita, T Matsui, M Wada, A Tsuji 27 5 832-40 2010/05
  •  Fibrocytes are involved in the pathogenesis of human chronic kidney disease N Sakai, K Furuichi, Y Shinozaki, H Yamauchi, T Toyama, S Kitajima, T Okumura, S Kokubo, M Kobayashi, K Takasawa, SI Takeda, M Yoshimura, S Kaneko, Wada T 41 5 672-8 2010/05
  •  Oncostatin m renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-Fluorouracil by inducing hepatocytic differentiation T Yamashita, M Honda, K Nio, Y Nakamoto, T Yamashita, H Takamura, T Tani, Y Zen, S Kaneko 70 11 4687-97 2010/06
  •  Altered firing pattern of single-unit muscle sympathetic nerve activity during handgrip exercise in chronic heart failure H Murai, M Takamura, M Maruyama, M Nakano, T Ikeda, D Kobayashi, K Otowa, H Ootsuji, M Okajima, H Furusho, S Takata, S Kaneko 587 Pt11 2613-22 2009/06
  •  La Protein Required for Internal Ribosome Entry Site-Directed Translation Is a Potential Therapeutic Target for Hepatitis C Virus Replication T Shirasaki, M Honda, H Mizuno, T Shimakami, H Okada, Y Sakai, S Murakami, T Wakita, S Kaneko 202 1 75-85 2010/07
  •  Hepatic ISG expression is associated with genetic variation in IL28B and the outcome of IFN therapy for chronic hepatitis C M Honda, A Sakai, T Yamashita, Y Nakamoto, E Mizukoshi, Y Sakai, T Yamashita, M Nakamura, T Shirasaki, K Horimoto, Y Tanaka, K Tokunaga, M Mizokami, S Kaneko; Hokuriku Liver Study Group 139 2 499-509 2010/08
  •  Antitumor Effect after Radiofrequency Ablation of Murine Hepatoma Is Augmented by an Active Variant of CC Chemokine Ligand 3/Macrophage Inflammatory Protein-1α N Iida, Y Nakamoto, T Baba, H Nakagawa, E Mizukoshi, M Naito, N Mukaida, S Kaneko 70 16 6556-65 2010/08
  •  Hepatocellular Carcinoma: Signal Intensity at Gadoxetic Acid-enhanced MR Imaging--Correlation with Molecular Transporters and Histopathologic Features A Kitao, Y Zen, O Matsui, T Gabata, S Kobayashi, W Koda, K Kozaka, N Yoneda, T Yamashita, S Kaneko, Y Nakanuma 256 3 817-26 2010/09
  •  Differential gene expression profiling in blood from patients with digestive system cancers M Honda, Y Sakai, T Yamashita, T Yamashita, A Sakai, E Mizukoshi, Y Nakamoto, I Tatsumi, Y Miyazaki, H Tanno, S Kaneko; Hokuriku Liver Study Group  400 1 7-15 2010/09
  •  A case of neurosarcoidosis with necrotizing granuloma expressing angiotensin-converting enzyme S Kitajima, N Sakai, K Furuichi, M Tomokage, A Hara, K Kitagawa, S Sawada Kitamura, Y Zen, M Nakada, S Kaneko, T Wada 20 5 506-10 2010/10
  •  Involvement of CD11b(+) GR-1 (low) cells in autoimmune disorder in MRL-Fas ( lpr ) mouse Y Iwata, K Furuichi, K Kitagawa, A Hara, T Okumura, S Kokubo, K Shimizu, N Sakai, A Sagara, Y Kurokawa, S Ueha, K Matsushima, S Kaneko, T Wada 14 5 411-7 2010/10
  •  Differential interferon signaling in liver lobule and portal area cells under treatment for chronic hepatitis C M Honda, M Nakamura, M Tateno, A Sakai, T Shimakami, T Shirasaki, T Yamashita, K Arai, T Yamashita, Y Sakai, S Kaneko 53 5 817-26 2010/11
  •  Detection of hepatitis B and C viruses in almost all hepatocytes by modified PCR-based in situ hybridization H Nuriya, K Inoue, T Tanaka, Y Hayashi, T Hishima, N Funata, K Kaji, S Hayashi, S Kaneko 48 11 3843-51 2010/11
  •  Efficacy and safety of double filtration plasmapheresis in combination with interferon therapy for chronic hepatitis C S Kaneko, M Sata, T Ide, T Yamashita, S Hige, E Tomita, S Mochida, Y Yamashita, Y Inui, SR Kim, N Komada, T Mikami, S Satoh, S Morita, K Takaguchi, N Hirashima, Y Nishio, D Watanabe, K Kioka, K Fujiwara 40 11 1072-81 2010/11
  •  A liver-derived secretory protein, selenoprotein P, causes insulin resistance  H Misu, T Takamura, H Takayama, H Hayashi, N Matsuzawa-Nagata, S Kurita, K Ishikura, H Ando, Y Takeshita, T Ota, M Sakurai, T Yamashita, E Mizukoshi, T Yamashita, M Honda, K Miyamoto, T Kubota, N Kubota, T Kadowaki, HJ Kim, IK Lee, Y Minokoshi, Y Saito, K Takahashi, Y Yamada, N Takakura, S Kaneko 12 5 483-95 2010/11
  •  Effect of pioglitazone on muscle sympathetic nerve activity in type 2 diabetes mellitus with alpha-glucosidase inhibitor D Kobayashi, M Takamura, H Murai, S Usui, T Ikeda, JI Inomata, SI Takashima, T Kato, H Furusho, Y Takeshita, T Ota, T Takamura, S Kaneko 158 1-2 86-91 2010/12
  •  Phase I/II study of the pharmacokinetics, safety and efficacy of S-1 in patients with advanced hepatocellular carcinoma J Furuse, T Okusaka, S Kaneko, M Kudo, K Nakachi, H Ueno, T Yamashita, K Ueshima 101 12 2606-11 2010/12

Conference Presentations

Arts and Fieldwork

Patent

○Composition for treating hepatitis c
○USE OF DIABETES-RELATED, LIVER-DERIVED SECRETED PROTEIN IN DIAGNOSIS OR TREATMENT OF TYPE-2 DIABETES OR VASCULAR DISORDER
○HEPATOCELLULAR CARCINOMA PROTEIN MARKER, AND METHOD FOR DETECTION OF HEPATOCELLULAR CARCINOMA USING THE SAME
○DETECTION OF DIGESTIVE SYSTEM CANCER, STOMACH CANCER, COLON CANCER, PANCREATIC CANCER, AND BILIARY TRACT CANCER BY MEANS OF GENE EXPRESSION PROFILING

Theme to the desired joint research

○Study for genomics in liver

Grant-in-Aid for Scientific Research

○「ウイルス性肝疾患に対する分子標的治療創薬に関する研究」(2010-2012) 
○「初発肝細胞癌に対する肝切除とラジオ波焼灼療法の有効性に関する多施設共同研究」(2009-2011) 
○「がん診療ガイドラインの作成(新規・更新)と公開の維持およびその在り方に関する研究」(2009-2011) 
○「主にアジアに蔓延するウイルス性肝疾患の制御に資する為の日米合作的肝炎ウイルス基礎研究」(2009-2011) 
○「幹細胞制御によるがん治療法開発のための基盤研究」(2009-2011) 
○「C型肝炎難治症例の病態解明と抗ウイルス治療に関する研究」(2009-2011) 
○「肝がんの新規治療法に関する研究」(2009-2011) 
○「ジェノミクス技術を用いたウイルス性肝炎に対する新規診断・治療法の開発」(2007-2009) 
○「ヒト肝細胞キメラマウスを用いた治療抵抗性の肝炎に関する研究」(2008-2010) 
○「過栄養状態における肝臓機能の破綻と生活習慣病の研究」(2006-2010) 
○「Transcriptional controlによる進行肝細胞癌の遺伝子治療」(1997-) 
○「血液浄化法によるC型肝炎ウイルス除法の試み」(1998-) 
○「肝内およぶ肝外転移を有する進行肝細胞癌に対する遺伝子治療法の確立」(1998-) 
○「癌に対するバイオセンサー型DNAチップの開発」(1999-) 
○「血液浄化法によるC型肝炎ウイルス除去の試み」(1999-) 
○「肝内および肝外転移を有する進行肝細胞癌に対する遺伝子治療法の確立」(1999-) 
○「チンパンジーを用いた血液浄化法によるC型肝炎ウイルス除去の試み」(1999-) 
○「癌に対するバイオセンサー型DNAチップの開発」(2000-) 
○「Genomicsを用いた早期肝細胞癌の診断開発研究」(2000-)
○「Genomicsを用いた早期肝細胞癌の診断開発研究」(2000-) 
○「進行肝細胞癌に対する新たな遺伝子治療ペクターの開発」(2000-) 
○「癌に対するバイオセンサー型DNAチップの開発」(2001-)
○「Genomics技術による新しい肝臓病学の確立」(2001-) 
○「癌に対するバイオセンサー型DNAチップの開発」(2001-) 
○「進行肝細胞に対する新たな遺伝子治療のベクターの開発」(2001-) 
○「肝細胞におけるFunctional Genomics 解析系の確立」(2001-) 
○「Genomics技術による新しい肝臓病学の確立」(2004-2005) 
○「進行肝がんに対する集学的治療に関する研究」(2004-2004) 
○「B型及びC型肝炎ウイルス感染者における新たな発がん予防法の確立のための肝がん発生等の病態解明に関する研究」(2004-2006) 
○「難治性自己免疫性肝疾患の画期的治療法の開発に関する臨床研究」(2004-2005) 
○「B型及びC型肝炎の疫学及び健診を含む肝炎対策に関する研究」(2004-2006) 
○「Genomics技術による新しい肝臓病学の確立」(2005-2005) 
○「B型及びC型肝炎の疫学及び健診を含む肝炎対策に関する研究」(2005-2006) 
○「B型及びC型肝炎ウイルスの新たな感染予防法の確立のための肝がん発生等の病態解明に関する研究」(2005-2006) 
○「難治性自己免疫性肝疾患の画期的治療法の開発に関する臨床研究」(2005-) 
○「B型及びC型肝炎の疫学及び健診を含む肝炎対策に関する研究」(2006-2006) 
○「B型及びC型肝炎ウイルス感染者における新たな発がん予防法の確立のための肝がん発生等の病態解明に関する研究」(2006-2006) 
○「C型肝炎新規治療開発に資するプロテオーム解析を用いた治療標的分子の網羅的検索系とヒト肝細胞キメラマウスHCV感染モデルを用いた実証系の開発に関する研究」(2005-2007) 
○「過栄養状態の肝臓が産生するタンパクと生活習慣病の関連」(2011-2013) 
○「創薬と新規治療法開発に資するヒト肝細胞キメラマウスを用いた肝炎ウイルス制御に関する研究」(2011-2013) 
○「進行肝細胞癌に対する集学的治療確立に関する研究」(2006-2008) 
○「電子化された肝癌診療ガイドラインの活用と評価に関する研究」(2004-) 
○「肝炎ウイルス検診の現状把握と評価及び今後のあり方に関する研究」(2006-) 

Classes (Bachelors)

○Nutrition & Gastroenterology(2017)
○Internal Medicine(BSL)(2017)
○General Medicine(2017)
○Internal Medicine(BSL)(2016)
○Nutrition & Gastroenterology(2016)

Classes (Graduate Schools)

○Disease Control and Homeotasis(2017)
○Disease Control and Homeotasis(2017)
○Introduction to Medicine(2017)
○Disease Control and Homeotasis(2017)
○omics(2017)
○Disease Control and Homeotasis(2016)
○Introduction to Medicine(2016)
○omics(2016)
○Disease Control and Homeotasis(2016)
○Disease Control and Homeotasis(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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