SASAKI Motoko - Directory of Researchers at Kanazawa University

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last modified：2025/04/07

Associate Professor　SASAKI Motoko

Basic
Research
Education
Social Contribution

Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences　Human Pathology

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

　TEL:076-265-2197　FAX:076-234-4229

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University　Doctor　Graduate School, Division of Medicine　1989　Other
【Academic background(Bachelor's Degree)】
Kanazawa University　1988

Career

Year & Month of Birth

Academic Society

International Academy of Pathology (IAP)
American Association for the study of liver diseases(AASLD)

International Academy of Pathology (IAP)

Award

Specialities

Human pathology、Pathology of the liver

Speciality Keywords

Pathology of the hepatobiliary diseases; primary biliary cholangitis (cirrhosis), Cholangiocarcinoma

Research Themes

Pathogenesis of Primary biliary cholangitis.

Immunohistochemical investigation of outbreak and development of intrahepatic bile duct cancer coexisting with intrahepatic lithiasis

Involvement of cellular senescence and autophagy in hepatobiliary diseases

Mucin core proteins in Hepatobiliary disease

Books

　Yamaguchi J,Sasaki M,Nakanuma Y　Cancer, etiology, diagnosis and treatments.　Nova Science Publishers, Inc., New York　2011/01/01
　Sasaki M,Nakanuma Y　AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging.　2013/01/01
　Ikeda H,Harada K,Sasaki M,Sato Y,Nakanuma Y　Tumor necrosis factor (ed.TP Rossard). Tumor necrosis factor-α and biliary tract diseases.　Nova Science Publishers, Inc., New York　2009/01/01
　Nakanuma Y,Sato Y,Hsu M,Ikeda H,Sasaki M,Harada K　Advances in Medicine and Biology. Volume 7. (ed. Berhardt, LV). Chapter V- Primary biliary cirrhosis: Pathology and pathogenesis　Nova Science Publishers, Inc., New York　2010/01/01
　Motoko Sasaki　Cellular senescence and biliary disorders　Pathology of the Bile Duct　39　2017/05/26

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　Sasaki M. 　Pathology of the bile duct.　Springer　2017/04/01
　Sasaki M　Biliary Diseases with Pancreatic Counterparts: A New Disease Concept. 　Nova Science publishers. 　2017/04/01
　Sasaki M, Nakanuma Y.　AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging.　2013/01/01
　Yamaguchi J, Sasaki M, Nakanuma Y.　Cancer, etiology, diagnosis and treatments. 　Nova Science Publishers, Inc., New York　2011/01/01
　Nakanuma Y, Sato Y, Hsu M, Ikeda H, Sasaki M, Harada K　Advances in Medicine and Biology. Volume 7. (ed. Berhardt, LV). Chapter V- Primary biliary cirrhosis: Pathology and pathogenesis　Nova Science Publishers, Inc., New York　2010/01/01

Papers

　Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: a possible role in bile duct loss.　Journal of Pathology　205　4　451-459　2005/03
　Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence.　Sasaki M, Ikeda H, Yamaguchi J, et al　HEPATOLOGY　48　186-195　2008/07
　A possible involvement of endoplasmic reticulum stress in biliary epithelial autophagy and senescence in primary biliary cirrhosis　Sasaki, Motoko; Yoshimura-Miyakoshi, Masami; Sato, Yasunori; Nakanuma, Yasuni　Journal of Gastroenterology　2015/01/01　
　Immunostaining for polycomb group protein EZH2 and senescent marker p16INK4a may be useful to differentiate cholangiolocellular carcinoma from ductular reaction and bile duct adenoma　Sasaki, Motoko; Matsubara, Takashi; Kakuda, Yuko; Sato, Yasunori; Nakanuma, Yasuni　American Journal of Surgical Pathology　38　3　364-369　2014/03/01　
　KRAS and GNAS mutations and p53 overexpression in biliary intraepithelial neoplasia and intrahepatic cholangiocarcinomas　Hsu, Maylee; Sasaki, Motoko; Igarashi, Saya; Sato, Yasunori; Nakanuma, Yasuni　Cancer　119　9　1669-1674　2013/05/01

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　A serum amyloid A-positive hepatocellular neoplasm arising in alcoholic cirrhosis: A previously unrecognized type of inflammatory hepatocellular tumor　Sasaki, Motoko; Yoneda, Norihide; Kitamura, Seiko; Sato, Yasunori; Nakanuma, Yasuni　Modern Pathology　25　12　1584-1593　2012/12/01　
　Increased expression of mitochondrial proteins associated with autophagy in biliary epithelial lesions in primary biliary cirrhosis　Sasaki, Motoko; Miyakoshi, Masami; Sato, Yasunori; Nakanuma, Yasuni　Liver International　33　2　312-320　2013/02/01　
　Pathogenesis of Bile Duct Lesions in Primary Biliary Cirrhosis: Role of Autophagy Followed by Cellular Senescence　Sasaki, Motoko; Nakanuma, Yasuni　Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging　293-303　2013/10/01　
　Autophagy may precede cellular senescence of bile ductular cells in ductular reaction in primary biliary cirrhosis　Sasaki, Motoko; Miyakoshi, Masami; Sato, Yasunori; Nakanuma, Yasuni　Digestive Diseases and Sciences　57　3　660-666　2012/03/01　
　Overexpression of enhancer of zeste homolog 2 and MUC1 may be related to malignant behaviour in intraductal papillary neoplasm of the bile duct　Sasaki, Motoko; Matsubara, Takashi; Yoneda, Norihide; Nomoto, Kazuhiro; Tsuneyama, Koichi; Sato, Yasunori; Nakanuma, Yasuni　Histopathology　62　3　446-457　2013/02/01　
　Site-characteristic expression and induction of trefoil factor family 1, 2 and 3 and malignant brain tumor-1 in normal and diseased intrahepatic bile ducts relates to biliary pathophysiology.　Liver International　24　1　29-37　2004/02
　Characterization of intraductal papillary neoplasm of bile duct with respect to histopathologic similarities to pancreatic intraductal papillary mucinous neoplasm　Yasuni Nakanuma,Yuko Kakuda,Katsuhiko Uesaka,Takashi Miyata,Yusuke Yamamoto,Yuki Fukumura,Yasunori Sato,Motoko Sasaki,Kenichi Harada,Masaru Takase　HUMAN PATHOLOGY　51　103　2016/05
　Benign Hepatocellular Nodules: Hepatobiliary Phase of Gadoxetic Acid-enhanced MR Imaging Based on Molecular Background　Norihide Yoneda,Osamu Matsui,Azusa Kitao,Kazuto Kozaka,Satoshi Kobayashi,Motoko Sasaki,Kotaro Yoshida,Dai Inoue,Tetsuya Minami,Toshifumi Gabata　RADIOGRAPHICS　36　7　2010　2016/11
　A possible involvement of endoplasmic reticulum stress in biliary epithelial autophagy and senescence in primary biliary cirrhosis　Motoko Sasaki,Masami Yoshimura-Miyakoshi,Yasunori Sato,Yasuni Nakanuma　JOURNAL OF GASTROENTEROLOGY　50　9　984　2015/09
　Clinicopathological characteristics of serum amyloid A-positive hepatocellular neoplasms/nodules arising in alcoholic cirrhosis.　Motoko Sasaki,Norihide Yoneda,Yoshiyuki Sawai,Yasuharu Imai,Fukuo Kondo,Toshio Fukusato,Seiichi Yoshikawa,Satoshi Kobayashi,Yasunori Sato,Osamu Matsui,Yasuni Nakanuma　Histopathology　66　6　836　2015/05
　Autophagy and senescence in fibrosing cholangiopathies　Yasuni Nakanuma,Motoko Sasaki,Kenichi Harada　JOURNAL OF HEPATOLOGY　62　4　934　2015/04
　In recurrent primary biliary cirrhosis after liver transplantation, biliary epithelial cells show increased expression of mitochondrial proteins　Motoko Sasaki,Maylee Hsu,Matthew M. Yeh,Yasuni Nakanuma　VIRCHOWS ARCHIV　467　4　417　2015/10
　Loss of ARID1A Expression Presents a Novel Pathway of Carcinogenesis in Biliary Carcinomas.　Motoko Sasaki,Takeo Nitta,Yasunori Sato,Yasuni Nakanuma　American journal of clinical pathology　145　6　815　2016/06
　Bile Acids and Deregulated Cholangiocyte Autophagy in Primary Biliary Cholangitis.　Motoko Sasaki,Yasuni Nakanuma　Digestive diseases (Basel, Switzerland)　35　3　210　2017
　Mutational landscape of combined hepatocellular carcinoma and cholangiocarcinoma, and its clinicopathological significance.　Motoko Sasaki,Yasunori Sato,Yasuni Nakanuma　Histopathology　70　3　423　2017/02
　Confluent hepatic fibrosis in alcohol liver cirrhosis with elevated pivkaii value - usefulness of immunostaining for EZH2 and p16(INK4a) in differentiating it from cholangiolocellular carcinoma - Confluent hepatic fibrosis.　Soo Ki Kim,Soo Ryang Kim,Susumu Imoto,Chi Wan Kim,Toshiyuki Matsuoka,Motoko Sasaki,Osamu Nakashima,Tsutomu Kumabe,Yoshitake Hayashi　Pathology international　66　9　543　2016/09　
　Altered intrahepatic microcirculation of idiopathic portal hypertension in relation to glutamine synthetase expression　Yasunori Sato,Kenichi Harada,Motoko Sasaki,Yasuni Nakanuma　HEPATOLOGY RESEARCH　45　13　1323　2015/12
　Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)　Daniel J. Klionsky,Daniel J. Klionsky,Kotb Abdelmohsen,Akihisa Abe,Md Joynal Abedin,Hagai Abeliovich,Abraham Acevedo Arozena,Hiroaki Adachi,Christopher M. Adams,Peter D. Adams,Khosrow Adeli,Peter J. Adhihetty,Sharon G. Adler,Galila Agam,Rajesh Agarwal,Manish K. Aghi,Maria Agnello,Patrizia Agostinis,Patricia V. Aguilar,Julio Aguirre-Ghiso,Julio Aguirre-Ghiso,Edoardo M. Airoldi,Edoardo M. Airoldi,Slimane Ait-Si-Ali,Takahiko Akematsu,Emmanuel T. Akporiaye,Mohamed Al-Rubeai,Guillermo M. Albaiceta,Chris Albanese,Diego Albani,Matthew L. Albert,Jesus Aldudo,Hana Algül,Mehrdad Alirezaei,Iraide Alloza,Iraide Alloza,Alexandru Almasan,Maylin Almonte-Beceril,Emad S. Alnemri,Covadonga Alonso,Nihal Altan-Bonnet,Dario C. Altieri,Silvia Alvarez,Lydia Alvarez-Erviti,Sandro Alves,Giuseppina Amadoro,Atsuo Amano,Consuelo Amantini,Santiago Ambrosio,Ivano Amelio,Amal O. Amer,Mohamed Amessou,Angelika Amon,Zhenyi An,Frank A. Anania,Stig U. Andersen,Usha P. Andley,Catherine K. Andreadi,Nathalie Andrieu-Abadie,Alberto Anel,David K. Ann,Shailendra Anoopkumar-Dukie,Manuela Antonioli,Manuela Antonioli,Hiroshi Aoki,Nadezda Apostolova,Saveria Aquila,Katia Aquilano,Koichi Araki,Eli Arama,Agustin Aranda,Jun Araya,Alexandre Arcaro,Esperanza Arias,Hirokazu Arimoto,Aileen R. Ariosa,Jane L. Armstrong,Thierry Arnould,Ivica Arsov,Katsuhiko Asanuma,Valerie Askanas,Eric Asselin,Ryuichiro Atarashi,Sally S. Atherton,Julie D. Atkin,Laura D. Attardi,Patrick Auberger,Georg Auburger,Laure Aurelian,Riccardo Autelli,Laura Avagliano,Laura Avagliano,Maria Laura Avantaggiati,Limor Avrahami,Neelam Azad,Suresh Awale,Tiziana Bachetti,Jonathan M. Backer,Dong Hun Bae,Jae Sung Bae　Autophagy　12　1　1　2016/01/21　
　A Case of Amyloidosis of the Gallbladder Secondary to Rheumatoid Arthritis　HAGINO Shigeta,NAKAYAMA Akira,SAKAMOTO Koya,SASAKI Motoko　Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)　78　3　585　2017　
　The PD-1/PD-L1 axis may be aberrantly activated in occupational cholangiocarcinoma.　Yasunori Sato,Masahiko Kinoshita,Shigekazu Takemura,Shogo Tanaka,Genya Hamano,Shoji Nakamori,Masahiro Fujikawa,Yasuhiko Sugawara,Takatsugu Yamamoto,Akira Arimoto,Minako Yamamura,Motoko Sasaki,Kenichi Harada,Yasuni Nakanuma,Shoji Kubo　Pathology international　67　3　163　2017/03　
　Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is a marker that predicts presence of invasion in papillary biliary tumors.　Motoko Sasaki,Yasunori Sato　Human pathology　62　152　2017/04　
　Stress-induced cellular responses and cell death mechanisms during inflammatory cholangiopathies.　Motoko Sasaki,Yasuni Nakanuma　Clinics and research in hepatology and gastroenterology　41　2　129　2017/03
　Bile duct adenoma in patient with chronic hepatitis C: As a benign neoplasm by pathological and imaging studies.　Soo Ki Kim,Soo Ryang Kim,Susumu Imoto,Chi Wan Kim,Toshiyuki Matsuoka,Osamu Nakashima,Motoko Sasaki,Tsutomu Kumabe,Masatoshi Kudo,Toshio Fukusato,Fukuo Kondo　Pathology international　66　11　640　2016/11　
　Paraptosis cell death induction by the thiamine analog benfotiamine in leukemia cells.　Naomi Sugimori,J Luis Espinoza,Ly Quoc Trung,Akiyoshi Takami,Yukio Kondo,Dao Thi An,Motoko Sasaki,Tomohiko Wakayama,Shinji Nakao　PloS one　10　4　e0120709　2015　
　Multiple hepatocellular adenomas: A case report　Fumito Tamura,Yutaka Kawano,Koji Miyanishi,Tomohiro Kubo,Yusuke Kamihara,Yutaka Okagawa,Kazuma Ishikawa,Kohichi Takada,Tsuyoshi Hayashi,Tsutomu Sato,Yasushi Sato,Masayoshi Kobune,Rishu Takimoto,Masaki Kawamoto,Makoto Meguro,Toru Mizuguchi,Ziro Ogino,Tadashi Hasegawa,Norihide Yoneda,Motoko Sasaki,Junji Kato　Acta Hepatologica Japonica　56　11　584　2015/12/04　
　New concept: cellular senescence in pathophysiology of cholangiocarcinoma　Motoko Sasaki,Yasuni Nakanuma　EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY　10　5　625　2016/05
　Notch-Hes1 signaling activation in Caroli disease and polycystic liver disease.　Kenta Takahashi,Yasunori Sato,Minako Yamamura,Satoko Nakada,Yuko Tamano,Motoko Sasaki,Kenichi Harada　Pathology international　71　8　521　2021/08
　The cyclin‑dependent kinase pathway involving CDK1 is a potential therapeutic target for cholangiocarcinoma.　Minako Yamamura,Yasunori Sato,Kenta Takahashi,Motoko Sasaki,Kenichi Harada　Oncology reports　43　1　306　2020/01
　An immunohistochemical panel of insulin-like growth factor II mRNA-binding protein 3 (IMP3), enhancer of zeste homolog 2 (EZH2), and p53 is useful for a diagnosis in bile duct biopsy.　Motoko Sasaki,Yasunori Sato　Virchows Archiv : an international journal of pathology　479　4　697　2021/10
　The clinicopathological characterization of small hepatocellular carcinoma with fibrous stroma.　Toshihiro Yagi,Yasuni Nakanuma,Yasunori Sato,Takeo Nitta,Motoko Sasaki,Toshifumi Gabata,Kenichi Harada　International journal of clinical and experimental pathology　11　10　4806　2018
　Asymptomatic giant cell hepatitis: a subtype of post-infantile giant cell hepatitis?　Takahiro Zenda,Ichiro Araki,Motoko Sasaki　Clinical journal of gastroenterology　12　4　367　2019/08
　Is nestin a diagnostic marker for combined hepatocellular–cholangiocarcinoma?　M Sasaki,Y Sato,Y Nakanuma　Histopathology　80　5　859　2022/04　
　Expression of fibroblast growth factor receptor 2 (FGFR2) in combined hepatocellular-cholangiocarcinoma and intrahepatic cholangiocarcinoma: clinicopathological study　Motoko Sasaki,Yasunori Sato,Yasuni Nakanuma　Virchows Archiv　484　6　915　2024/03/27　
　Amiodarone-induced reversible and irreversible hepatotoxicity: two case reports.　Toyonobu Tsuda,Hayato Tada,Yoshihiro Tanaka,Naoto Nishida,Taiji Yoshida,Takeshi Sawada,Kenji Sakata,Kenshi Hayashi,Masa-Aki Kawashiri,Takeru Oyama,Motoko Sasaki,Nozomu Kurose,Masakazu Yamagishi　Journal of medical case reports　12　1　95　2018/04/14　
　An impaired biliary bicarbonate umbrella may be involved in dysregulated autophagy in primary biliary cholangitis.　Motoko Sasaki,Yasunori Sato,Yasuni Nakanuma　Laboratory investigation; a journal of technical methods and pathology　98　6　745　2018/06　
　Increased expression of senescence-associated cell cycle regulators in the progression of biliary atresia: an immunohistochemical study.　Motoko Sasaki,Fang-Ying Kuo,Chao-Cheng Huang,Paul E Swanson,Chao-Long Chen,Jiin-Haur Chuang,Matthew M Yeh　Histopathology　72　7　1164　2018/06　
　Blockade of Hedgehog Signaling Attenuates Biliary Cystogenesis in the Polycystic Kidney (PCK) Rat.　Yasunori Sato,Minako Yamamura,Motoko Sasaki,Kenichi Harada　The American journal of pathology　188　10　2251　2018/10
　[A Case of Peritoneal Mesothelioma Diagnosed by Ileus].　Hirofumi Terakawa,Ryosuke Gabata,Yusuke Haba,Satoshi Takada,Koya Sakamoto,Motoko Sasaki　Gan to kagaku ryoho. Cancer & chemotherapy　46　6　1081　2019/06
　MET amplification results in heterogeneous responses to osimertinib in EGFR-mutant lung cancer treated with erlotinib.　Akihiro Nishiyama,Shinji Takeuchi,Yuta Adachi,Sakiko Otani,Azusa Tanimoto,Motoko Sasaki,Shingo Matsumoto,Koichi Goto,Seiji Yano　Cancer science　111　10　3813　2020/10
　Interferon-induced protein with tetratricopeptide repeats 3 may be a key factor in primary biliary cholangitis.　Motoko Sasaki,Yasunori Sato,Yasuni Nakanuma　Scientific reports　11　1　11413　2021/06/01
　Drug-induced sarcoidosis-like reaction three months after BNT162b2 mRNA COVID-19 vaccination: A case report and review of literature.　Soo Ryang Kim,Soo Ki Kim,Takako Fujii,Hisato Kobayashi,Toyokazu Okuda,Takanobu Hayakumo,Atsushi Nakai,Yumi Fujii,Ryuji Suzuki,Noriko Sasase,Aya Otani,Yu-Ichiro Koma,Motoko Sasaki,Tsutomu Kumabe,Osamu Nakashima　World journal of clinical cases　11　1　177　2023/01/06
　Fulminant myocarditis and pulmonary cavity lesion induced by disseminated mucormycosis in a chronic hemodialysis patient: Report of an autopsied case.　Yuhei Fujisawa,Satoshi Hara,Takeshi Zoshima,Naoto Maekawa,Dai Inoue,Motoko Sasaki,Tadatsugu Gamou,Yoji Nagata,Kenshi Hayashi,Akari Takeji,Kiyoaki Ito,Ichiro Mizushima,Hiroshi Fujii,Mitsuhiro Kawano　Pathology international　70　8　557　2020/08
　Cholangiolocellular Carcinoma With "Ductal Plate Malformation" Pattern May Be Characterized by ARID1A Genetic Alterations.　Motoko Sasaki,Yasunori Sato,Yasuni Nakanuma　The American journal of surgical pathology　43　3　352　2019/03
　Immunosuppressive tumor microenvironment in occupational cholangiocarcinoma: Supportive evidence for the efficacy of immune checkpoint inhibitor therapy.　Yasunori Sato,Shogo Tanaka,Masahiko Kinoshita,Shigekazu Takemura,Hiroji Shinkawa,Takashi Kokudo,Kiyoshi Hasegawa,Hiromu Tanaka,Hidero Yoshimoto,Akira Mori,Minako Yamamura,Motoko Sasaki,Kenichi Harada,Shoji Kubo　Journal of hepato-biliary-pancreatic sciences　27　11　860　2020/11
　Recognition and pathological features of periampullary region adenocarcinoma with an indeterminable origin.　Ryuji Komine,Motohiro Kojima,Genichiro Ishi,Masashi Kudo,Motokazu Sugimoto,Shin Kobayashi,Shinichiro Takahashi,Masaru Konishi,Tatsushi Kobayashi,Tetsuo Akimoto,Ayumi Murakami,Motoko Sasaki,Mariko Tanaka,Akiko Matsuzaki,Nobuyuki Ohike,Katsunori Uchida,Tomoko Sugiyama,Kenichi Hirabayashi,Takuma Tajiri,Kazuyuki Ishida,Keita Kai,Yuko Omori,Kenji Notohara,Hiroshi Yamaguchi,Yoko Matsuda,Yoshiki Naito,Yuki Fukumura,Yoshihiro Hamada,Yumi Mihara,Yohei Masugi,Naoto Gotohda,Kenichi Harada,Noriyoshi Fukushima,Toru Furukawa　Cancer medicine　10　11　3499　2021/06
　An involvement of Hippo-yes-associated protein pathway in biliary epithelial senescence in primary biliary cholangitis.　Motoko Sasaki,Yasunori Sato,Yasuni Nakanuma　Clinics and research in hepatology and gastroenterology　47　4　102106　2023/02/26
　Hepatic Inflammatory Pseudotumor-Focusing on Its Heterogeneity.　Soo Ryang Kim,Soo Ki Kim,Yu-Ichiro Koma,Motoko Sasaki,Akira Asai,Hiroki Nishikawa　Diagnostics (Basel, Switzerland)　13　17　2023/09/04
　Identification of a Transmembrane Protein Involved in Shear Stress Signaling and Hepatocarcinogenesis After a Sustained Virological Response to Hepatitis C Virus.　Masashi Nishikawa,Hikari Okada,Kazunori Kawaguchi,Tetsuro Shimakami,Kouki Nio,Kuniaki Arai,Tatsuya Yamashita,Motoko Sasaki,Shuichi Kaneko,Taro Yamashita,Masao Honda　Cellular and molecular gastroenterology and hepatology　16　2　263　2023
　Nestin may be a candidate marker for differential diagnosis between small duct type and large duct type intrahepatic cholangiocarcinomas　Motoko Sasaki,Yasunori Sato,Yasuni Nakanuma　Pathology - Research and Practice　253　155061　2024/01
　Increased p16INK4a-expressing senescent bile ductular cells are associated with inadequate response to ursodeoxycholic acid in primary biliary cholangitis.　Motoko Sasaki,Yasunori Sato,Yasuni Nakanuma　Journal of autoimmunity　107　102377　2020/02
　Clinical features and diagnostic imaging of cholangiolocellular carcinoma compared with other primary liver cancers: a surgical perspective　Hiroyuki Takamura,Ryousuke Gabata,Yoshinao Obatake,Shinichi Nakanuma,Hironori Hayashi,Kazuto Kozaka,Motoko Sasaki,Mitsuyoshi Okazaki,Takahisa Yamaguchi,Hiroyuki Shimbashi,Shiro Terai,Koichi Okamoto,Isamu Makino,Jun Kinoshita,Keishi Nakamura,Tomoharu Miyashita,Hidehiro Tajima,Itasu Ninomiya,Sachio Fushida,Azusa Kitao,Masaaki Kitahara,Kuniaki Arai,Taro Yamashita,Tatsuya Yamashita,Hiroko Ikeda,Yasunori Satoh,Kenichi Harada,Syuichi Kaneko,Toshihumi Gabata,Tateo Kosaka,Tetsuo Ohta　Technology in cancer research & treatment　19　2020/01/01
　Bile duct adenoma and small‐sized small duct type intrahepatic cholangiocarcinoma show distinct differences in genetic alterations, expression of IMP3 and EZH2 and stromal and inflammatory components　Motoko Sasaki,Yasunori Sato,Yasuni Nakanuma　Histopathology　83　2　298　2023/05/04　
　低分子デキストラン製剤が骨髄に沈着し貧血の原因と考えられた維持透析症例の解析(Anemia associated with dextran deposits in bone marrow tissues of patients undergoing hemodialysis)　杉森尚美,中村万理,原田憲一,佐々木素子,経田克則,中川詩織,原章規,古市賢吾　臨床血液　59　9　1761　2018/09
　Bile duct adenoma may be a precursor lesion of small duct type intrahepatic cholangiocarcinoma.　Motoko Sasaki,Yasunori Sato,Yasuni Nakanuma　Histopathology　78　2　310　2021/01
　A heterogeneous subtype of biliary epithelial senescence may be involved in the pathogenesis of primary biliary cholangitis　Motoko Sasaki,Yasunori Sato,Yasuni Nakanuma　Clinics and Research in Hepatology and Gastroenterology　49　1　102512　2025/01
　A Pathological Assessment of the Microvasculature of Biliary Tract Neoplasms Referring to Pre-Existing Blood Vessels and Vessel Co-Option　Yasuni Nakanuma,Zihan Li,Yasunori Sato,Motoko Sasaki,Kenichi Harada,Yuko Kakuda,Takashi Sugino　Cancers　16　22　3869　2024/11/19　?
　Is the significance of cell ballooning lost?　10　1　13-18　2024
　Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is a marker that predict presence of invasion in papillary biliary tumors. 　Sasaki M, Sato Y.　Hum Pathol　62　Apr　152-159　2017/04/01
　Cholangiolocellular Carcinoma With "Ductal Plate Malformation" Pattern may be Characterized by ARID1A Genetic Alterations.　Sasaki M, Sato Y, Nakanuma Y　Am J Surg Pathol. 　43　3　352-360　2019/03/01
　Asymptomatic giant cell hepatitis: a subtype of post-infantile giant cell hepatitis?　Zenda T, Araki I, Sasaki M.　 Clin J Gastroenterol 　2019/03/01
　An impaired biliary bicarbonate umbrella may be involved in dysregulated autophagy in primary biliary cholangitis. 　Sasaki M, Sato Y, Nakanuma Y　Lab Invest.　98　6　745-754　2018/06/01
　Blockade of Hedgehog Signaling Attenuates Biliary Cystogenesis in the Polycystic Kidney (PCK) Rat.　Sato Y, Yamamura M, Sasaki M, Harada K.　Am J Pathol.　188　10　2251-2263　2018/10/01
　Increased expression of senescence-associated cell cycle regulators in the progression of biliary atresia: an immunohistochemical study.　Sasaki M, Kuo FY, Huang CC, Swanson PE, Chen CL, Chuang JH, Yeh MM.　Histopathology.　72　7　1164-1171　2018/07/01
　Amiodarone-induced reversible and irreversible hepatotoxicity: two case reports　Tsuda T, Tada H, Tanaka Y, Nishida N, Yoshida T, Sawada T, Sakata K, Hayashi K, Kawashiri M, Oyama T, Sasaki M, Kurose N, Yamagishi M. 　J Med Case Rep　12　1　95　2018/01/01
　Increased p16INK4a-expressing senescent bile ductular cells are associated with inadequate response to ursodeoxycholic acid in primary biliary cholangitis.　Sasaki M, Sato Y, Nakanuma Y　J Autoimmun　102377　2019/12/04
　[A Case of Peritoneal Mesothelioma Diagnosed by Ileus]　Terakawa H, Gabata R, Haba Y, Takada S, Sakamoto K, Sasaki M　Gan To Kagaku Ryoho　46　6　1081-1083　2019/07/01
　The cyclin-dependent kinase pathway involving CDK1 is a potential therapeutic target for cholangiocarcinoma.　Yamamura M, Sato Y, Takahashi K, Sasaki M, Harada K　Oncol Rep　43　1　306-317　2020/01/01
　特集：　自己免疫性肝疾患. II. 基礎　胆管上皮細胞　78　1　27-33　2020/01/01
　Are bile duct lesions of primary biliary cirrhosis distinguishable from those of autoimmune hepatitis and chronic viral hepatitis? Interobserver histological agreement on trimmed bile ducts　Y. H. Zen, K.;Sasaki, M.;Tsuneyama, K.;Matsui, K.;Haratake, J.;Sakisaka, S.;Maeyama, S.;Yamamoto, K.;Nakano, M.;Shimamatsu, K.;Kage, M.;Kurose, N.;Uchiyama, A.;Kaizaki, Y.;Toda, G.;Nakanuma, Y.　J Gastroenterol　40　2　164-70　2005
　B7-2 positive cells around interlobular bile ducts in primary biliary cirrhosis and chronic hepatitis C　K. T. Kaji, K.;Nakanuma, Y.;Harada, K.;Sasaki, M.;Kaneko, S.;Kobayashi, K.　J Gastroenterol Hepatol　12　7　507-12　1997
　Interaction of Toll-like receptors with bacterial components induces expression of CDX2 and MUC2 in rat biliary epithelium in vivo and in culture　H. S. Ikeda, M.;Ishikawa, A.;Sato, Y.;Harada, K.;Zen, Y.;Kazumori, H.;Nakanuma, Y.　Lab Invest　87　6　559-71　2007
　Different expression patterns of mucin core proteins and cytokeratins during intrahepatic cholangiocarcinogenesis from biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct--an immunohistochemical study of 110 cases of hepatolithiasis　Y. S. Zen, M.;Fujii, T.;Chen, T. C.;Chen, M. F.;Yeh, T. S.;Jan, Y. Y.;Huang, S. F.;Nimura, Y.;Nakanuma, Y.　J Hepatol　44　2　350-8　2006
　Inhibition of intrahepatic bile duct dilation of the polycystic kidney rat with a novel tyrosine kinase inhibitor gefitinib　Y. H. Sato, K.;Furubo, S.;Kizawa, K.;Sanzen, T.;Yasoshima, M.;Ozaki, S.;Isse, K.;Sasaki, M.;Nakanuma, Y.　Am J Pathol　169　4　1238-50　2006
　Expression of MAGE-A3 in intrahepatic cholangiocarcinoma and its precursor lesions　K. S. Tsuneyama, M.;Shimonishi, T.;Nakanuma, Y.　Pathol Int　54　3　181-6　2004
　Site-characteristic expression and induction of trefoil factor family 1, 2 and 3 and malignant brain tumor-1 in normal and diseased intrahepatic bile ducts relates to biliary pathophysiology　M. T. Sasaki, K.;Saito, T.;Kataoka, H.;Mollenhauer, J.;Poustka, A.;Nakanuma, Y.　Liver Int　24　1　29-37　2004
　Expression of trefoil factor family 1, 2, and 3 peptide is augmented in hepatolithiasis　M. I. Sasaki, H.;Ohira, S.;Ishikawa, A.;Nakanuma, Y.　Peptides　25　5　763-70　2004
　Retroperitoneal mucinous cystadenoma: report of two cases and review of the literature　K. H. Isse, K.;Suzuki, Y.;Ishiguro, K.;Sasaki, M.;Kajiura, S.;Nakanuma, Y.　Pathol Int　54　2　132-8　2004
　Expression of MUC apomucins in normal pancreas and pancreatic tumours　T. O. Terada, T.;Sasaki, M.;Nakanuma, Y.;Kim, Y. S.　J Pathol　180　2　160-5　1996
　Intrahepatic cholangiocarcinoma arising in autosomal dominant polycystic kidney disease　M. K. Sasaki, K.;Watanabe, K.;Takasawa, K.;Nakanuma, Y.　Virchows Arch　441　1　98-100　2002
　Primary squamous cell carcinoma of the liver producing parathyroid hormone-related protein　T. H. Saito, K.;Tsuneyama, K.;Hirano, M.;Amaya, S.;Sasaki, M.;Kaneko, S.;Kobayashi, K.;Nakanuma, Y.　J Gastroenterol　37　2　138-42　2002
　Biliary papillary neoplasm of the liver　Y. S. Nakanuma, M.;Ishikawa, A.;Tsui, W.;Chen, T. C.;Huang, S. F.　Histol Histopathol　17　3　851-61　2002
　Intrahepatic cholangitis and arteritis after transcatheter arterial embolization in a patient with tumor-like lesion-associated autoimmune hepatitis　M. S. Iwata, M.;Harada, K.;Kaneko, S.;Kobayashi, K.;Adachi, K.;Sasaki, M.;Nakanuma, Y.　Pathol Res Pract　197　1　59-63　2001
　Precancerous lesions of intrahepatic cholangiocarcinoma　T. S. Shimonishi, M.;Nakanuma, Y.　J Hepatobiliary Pancreat Surg　7　6　542-50　2000
　Comparative immunoreactivity of anti-trifluoroacetyl (TFA) antibody and anti-lipoic acid antibody in primary biliary cirrhosis: searching for a mimic　M. A. Sasaki, A.;Pumford, N.;van de Water, J.;Leung, P. S.;Humphries, K. M.;Szweda, L. I.;Nakanuma, Y.;Roche, T. E.;Coppel, R. L.;Bach, J. F.;Gershwin, M. E.　J Autoimmun　15　1　51-60　2000
　Definition and pathology of primary sclerosing cholangitis　Y. H. Nakanuma, K.;Katayanagi, K.;Tsuneyama, K.;Sasaki, M.　J Hepatobiliary Pancreat Surg　6　4　333-42　1999
　Autoimmune cholangitis in the SJL/J mouse is antigen non-specific　M. A. Sasaki, J.;Odin, J. A.;Thung, S. N.;Coppel, R.;Nakanuma, Y.;Gershwin, M. E.　Dev Immunol　9　2　103-11　2002
　Increased MUC6 apomucin expression is a characteristic of reactive biliary epithelium in chronic viral hepatitis　M. N. Sasaki, Y.;Ho, S. B.;Kim, Y. S.　J Pathol　185　2　191-8　1998
　Cholangiocarcinomas arising in cirrhosis and combined hepatocellular-cholangiocellular carcinomas share apomucin profiles　M. N. Sasaki, Y.;Ho, S. B.;Kim, Y. S.　Am J Clin Pathol　109　3　302-8　1998
　Expression of apomucins in the intrahepatic biliary tree in hepatolithiasis differs from that in normal liver and extrahepatic biliary obstruction　M. N. Sasaki, Y.;Kim, Y. S.　Hepatology　27　1　54-61　1998
　Microstructure and development of the normal and pathologic biliary tract in humans, including blood supply　Y. H. Nakanuma, M.;Sanzen, T.;Sasaki, M.　Microsc Res Tech　38　6　552-70　1997
　Abnormal expression of MUC1 apomucin and mature MUC1 mucin in biliary epithelial cells in various cystic liver diseases　M. N. Sasaki, Y.　Hepatology　24　3　539-43　1996
　[Mucinous cholangiocarcinoma]　M. T. Sasaki, T.;Nakanuma, Y.　Ryoikibetsu Shokogun Shirizu　7　423-5　1995
　[Intrahepatic sarcomatoid cholangiocarcinoma]　M. T. Sasaki, T.;Nakanuma, Y.　Ryoikibetsu Shokogun Shirizu　7　408-10　1995
　Pathological and immunohistochemical findings in a case of mucinous cholangiocarcinoma　M. N. Sasaki, Y.;Shimizu, K.;Izumi, R.　Pathol Int　45　10　781-6　1995
　Biliary epithelial expression of MUC1, MUC2, MUC3 and MUC5/6 apomucins during intrahepatic bile duct development and maturation. An immunohistochemical study　M. N. Sasaki, Y.;Terada, T.;Kim, Y. S.　Am J Pathol　147　3　574-9　1995
　Hepatocellular prolapse of hepatic portal tracts and subendothelial space of central veins in idiopathic portal hypertension　M. N. Sasaki, Y.;Watanabe, K.　Histopathology　27　1　67-70　1995
　Expression of glycoconjugates during intrahepatic bile duct development in the rat: an immunohistochemical and lectin-histochemical study　T. Y. Sanzen, K.;Sasaki, M.;Terada, T.;Nakanuma, Y.　Hepatology　22　3　944-51　1995
　Hemosiderin deposition in portal endothelial cells: a novel hepatic hemosiderosis frequent in chronic viral hepatitis B and C　K. N. Kaji, Y.;Sasaki, M.;Unoura, M.;Kobayashi, K.;Nonomura, A.　Hum Pathol　26　10　1080-5　1995
　Pathology of the spleen in primary biliary cirrhosis: an autopsy study　N. M. Terayama, K. P.;Kobayashi, S.;Nakanuma, Y.;Sasaki, M.;Saito, K.;Katayanagi, K.　Pathol Int　44　43019　753-8　1994
　Expression of mucin core protein of mammary type in primary liver cancer　M. N. Sasaki, Y.　Hepatology　20　5　1192-7　1994
　Membranous expression of Lewis Y antigen in clustered hepatocytes in chronic viral, autoimmune, and alcoholic liver diseases but not in biliary diseases　M. K. Sasaki, N.;Nakanuma, Y.　Mod Pathol　7　3　339-46　1994
　Neoexpression of Lewis Y antigen is a sensitive phenotypic change of the damaged intrahepatic bile ducts　M. K. Sasaki, N.;Nakanuma, Y.　Hepatology　19　1　138-44　1994
　Pseudolipoma of Glisson's capsule. Report of six cases and review of the literature　M. H. Sasaki, K.;Nakanuma, Y.;Watanabe, K.　J Clin Gastroenterol　19　1　27607　1994
　Intrahepatic peribiliary glands of humans. II. Pathological spectrum　Y. S. Nakanuma, M.;Terada, T.;Harada, K.　J Gastroenterol Hepatol　9　1　29373　1994
　Succinylated wheat germ agglutinin lectin binding in intrahepatic vessels. A new histochemical tool　Y. S. Nakanuma, M.;Kono, N.　Arch Pathol Lab Med　117　8　809-11　1993
　Hilar cholangiocarcinoma (Klatskin tumor) arising from intrahepatic peribiliary glands　T. S. Terada, M.;Nakanuma, Y.;Takeda, Y.;Masunaga, T.　J Clin Gastroenterol　15　1　79-81　1992
　Multinodular deposition of AA-type amyloid localized in the adrenal glands of an old man　M. K. Sasaki, N.;Nakanuma, Y.;Ishiura, Y.　Acta Pathol Jpn　42　12　893-6　1992
　Intrahepatic cholangiocarcinoma with sarcomatous transformation: an autopsy case　M. N. Sasaki, Y.;Nagai, Y.;Nonomura, A.　J Clin Gastroenterol　13　2　220-5　1991
　Anorectal mucinous adenocarcinoma associated with latent perianal Paget's disease　M. T. Sasaki, T.;Nakanuma, Y.;Kono, N.;Kasahara, Y.;Watanabe, K.　Am J Gastroenterol　85　2　199-202　1990
　Amyloid deposition in intrahepatic large bile ducts and peribiliary glands in systemic amyloidosis　M. N. Sasaki, Y.;Terada, T.;Hoso, M.;Saito, K.;Hayashi, M.;Kurumaya, H.　Hepatology　12　4 Pt 1　743-6　1990
　Fatty macroregenerative nodule in non-steatotic liver cirrhosis. A morphologic study　T. N. Terada, Y.;Hoso, M.;Saito, K.;Sasaki, M.;Nonomura, A.　Virchows Arch A Pathol Anat Histopathol　415　2　131-6　1989
　Expression of blood group-related antigens in the intrahepatic biliary tree and hepatocytes in normal livers and various hepatobiliary diseases　Y. S. Nakanuma, M.　Hepatology　10　2　174-8　1989
　[Pathological study of hepatolithiasis with special reference to unusual cases]　Y. O. Nakanuma, G.;Yamaguchi, K.;Koga, A.;Yamamoto, K.;Sasaki, M.;Doishita, K.;Yoshikawa, T.;Hanyu, F.;Takahashi, W.;et al.,　Nihon Geka Gakkai Zasshi　85　9　1114-8　1984
　Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: a possible role in bile duct loss　M. I. Sasaki, H.;Haga, H.;Manabe, T.;Nakanuma, Y.　J Pathol　205　4　451-9　2005
　Abundant IgG4-positive plasma cell infiltration characterizes chronic sclerosing sialadenitis (Kuttner's tumor)　S. Z. Kitagawa, Y.;Harada, K.;Sasaki, M.;Sato, Y.;Minato, H.;Watanabe, K.;Kurumaya, H.;Katayanagi, K.;Masuda, S.;Niwa, H.;Tsuneyama, K.;Saito, K.;Haratake, J.;Takagawa, K.;Nakanuma, Y.　Am J Surg Pathol　29　6　783-91　2005
　Frequent p16ink4a inactivation is an early and frequent event of intraductal papillary neoplasm of the liver arising in hepatolithiasis　A. S. Ishikawa, M.;Sato, Y.;Ohira, S.;Chen, M. F.;Huang, S. F.;Oda, K.;Nimura, Y.;Nakanuma, Y.　Hum Pathol　35　12　1505-14　2004
　Combined hepatocellular and cholangiocarcinoma with marked squamous cell carcinoma components arising in non-cirrhotic liver　K. K. Tsuneyama, Y.;Doden, K.;Kidani, E.;Harada, K.;Sasaki, M.;Nakanuma, Y.　Pathol Int　53　2　33055　2003
　Intrahepatic cholangiocarcinoma in cirrhosis presents granulocyte and granulocyte-macrophage colony-stimulating factor　M. T. Sasaki, K.;Ishikawa, A.;Nakanuma, Y.　Hum Pathol　34　12　1337-44　2003
　Aberrant expression of trefoil factor family 1 in biliary epithelium in hepatolithiasis and cholangiocarcinoma　M. T. Sasaki, K.;Nakanuma, Y.　Lab Invest　83　10　1403-13　2003
　Decrease of deleted in malignant brain tumour-1 (DMBT-1) expression is a crucial late event in intrahepatic cholangiocarcinoma　M. H. Sasaki, S. F.;Chen, M. F.;Jan, Y. Y.;Yeh, T. S.;Ishikawa, A.;Mollenhauer, J.;Poustka, A.;Tsuneyama, K.;Nimura, Y.;Oda, K.;Nakanuma, Y.　Histopathology　43　4　340-6　2003
　Expression of deleted in malignant brain tumor-1 (DMBT1) molecule in biliary epithelium is augmented in hepatolithiasis: possible participation in lithogenesis　M. H. Sasaki, S. F.;Chen, M. F.;Jan, Y. Y.;Yeh, T. S.;Ishikawa, A.;Mollenhauer, J.;Poustka, A.;Tsuneyama, K.;Nimura, Y.;Oda, K.;Nakanuma, Y.　Dig Dis Sci　48　7　1234-40　2003
　Anatomic and molecular pathology of intrahepatic cholangiocarcinoma　Y. H. Nakanuma, K.;Ishikawa, A.;Zen, Y.;Sasaki, M.　J Hepatobiliary Pancreat Surg　10　4　265-81　2003
　Expression of MUC1 and MUC2 mucin core proteins and their messenger RNA in gall bladder carcinoma: an immunohistochemical and in situ hybridization study　T. S. Yamato, M.;Watanabe, Y.;Nakanuma, Y.　J Pathol　188　1　42946　1999
　A case report of gastric carcinosarcoma with rhabdomyosarcomatous and neuroendocrinal differentiation　K. S. Tsuneyama, M.;Sabit, A.;Yokoi, K.;Arano, Y.;Imai, T.;Nakanuma, Y.　Pathol Res Pract　195　2　93-7; discussion 98　1999
　Damaged interlobular bile ducts in primary biliary cirrhosis show reduced expression of glutathione-S-transferase-pi and aberrant expression of 4-hydroxynonenal　K. H. Tsuneyama, K.;Kono, N.;Sasaki, M.;Saito, T.;Gershwin, M. E.;Ikemoto, M.;Arai, H.;Nakanuma, Y.　J Hepatol　37　2　176-83　2002
　The SJL/J mouse is not a model for PBC　M. L. Sasaki, S. A.;Van De Water, J.;He, X. S.;Shultz, L.;Coppel, R. L.;Ansari, A.;Nakanuma, Y.;Gershwin, M. E.　Hepatology　35　5　1284-6　2002
　The immunopathology of primary biliary cirrhosis: thoughts for the millennium　M. A. Sasaki, A. A.;Nakanuma, Y.;Coppel, R. L.;Keeffe, E. B.;Gershwin, M. E.　Arch Immunol Ther Exp (Warsz)　48　1　42745　2000
　Destruction of bile ducts in primary biliary cirrhosis　Y. T. Nakanuma, K.;Sasaki, M.;Harada, K.　Baillieres Best Pract Res Clin Gastroenterol　14　4　549-70　2000
　Evidence of the participation of peribiliary mast cells in regulation of the peribiliary vascular plexus along the intrahepatic biliary tree　W. H. Koda, K.;Tsuneyama, K.;Kono, N.;Sasaki, M.;Matsui, O.;Nakanuma, Y.　Lab Invest　80　7　1007-17　2000
　Amplification and sequence analysis of partial bacterial 16S ribosomal RNA gene in gallbladder bile from patients with primary biliary cirrhosis　K. H. Hiramatsu, K.;Tsuneyama, K.;Sasaki, M.;Fujita, S.;Hashimoto, T.;Kaneko, S.;Kobayashi, K.;Nakanuma, Y.　J Hepatol　33　1　42996　2000
　Aberrant expression of stem cell factor on biliary epithelial cells and peribiliary infiltration of c-kit-expressing mast cells in hepatolithiasis and primary sclerosing cholangitis: a possible contribution to bile duct fibrosis　K. K. Tsuneyama, N.;Yamashiro, M.;Kouda, W.;Sabit, A.;Sasaki, M.;Nakanuma, Y.　J Pathol　189　4　609-14　1999
　Expression of sialyl-Tn, Tn and T antigens in primary liver cancer　M. Y. Sasaki, T.;Nakanuma, Y.　Pathol Int　49　4　325-31　1999
　Expression of MUC2, MUC5AC and MUC6 apomucins in carcinoma, dysplasia and non-dysplastic epithelia of the gallbladder　M. Y. Sasaki, T.;Nakanuma, Y.;Ho, S. B.;Kim, Y. S.　Pathol Int　49　1　38-44　1999
　Frequent expression of MUC1 apomucin on biliary epithelial cells of damaged small bile ducts in primary biliary cirrhosis and chronic viral hepatitis: an immunohistochemical study　M. N. Sasaki, Y.　Hepatology　23　6　1313-7　1996
　Characterization of apomucin expression in intrahepatic cholangiocarcinomas and their precursor lesions: an immunohistochemical study　M. N. Sasaki, Y.;Kim, Y. S.　Hepatology　24　5　1074-8　1996
　Carcinoembryonic antigen and blood group-related carbohydrate antigens in glycoproteins in human bile in hepatolithiasis. Japanese Study Group of Hepatolithiasis　M. M. Sasaki, T.;Hoso, M.;Nakanuma, Y.;Tanimura, H.　Hepatology　23　2　258-63　1996
　Immunohistochemical analysis of the progression of flat and papillary preneoplastic lesions in intrahepatic cholangiocarcinogenesis in hepatolithiasis　K. Z. Itatsu, Y.;Ohira, S.;Ishikawa, A.;Sato, Y.;Harada, K.;Ikeda, H.;Sasaki, M.;Nimura, Y.;Nakanuma, Y.　Liver Int　27　9　1174-84　2007
　Intraductal papillary cholangiocarcinoma and atypical biliary epithelial lesions confused with intrabiliary extension of metastatic colorectal carcinoma　K. F. Itatsu, T.;Sasaki, M.;Zen, Y.;Nakanuma, Y.　Hepatogastroenterology　54　75　677-80　2007
　Local balance of transforming growth factor-beta1 secreted from cholangiocarcinoma cells and stromal-derived factor-1 secreted from stromal fibroblasts is a factor involved in invasion of cholangiocarcinoma　S. I. Ohira, K.;Sasaki, M.;Harada, K.;Sato, Y.;Zen, Y.;Ishikawa, A.;Oda, K.;Nagasaka, T.;Nimura, Y.;Nakanuma, Y.　Pathol Int　56　7　381-9　2006
　Possible regulation of migration of intrahepatic cholangiocarcinoma cells by interaction of CXCR4 expressed in carcinoma cells with tumor necrosis factor-alpha and stromal-derived factor-1 released in stroma　S. S. Ohira, M.;Harada, K.;Sato, Y.;Zen, Y.;Isse, K.;Kozaka, K.;Ishikawa, A.;Oda, K.;Nimura, Y.;Nakanuma, Y.　Am J Pathol　168　4　1155-68　2006
　Hepatocellular carcinoma arising in primary biliary cirrhosis presenting with nodular regenerative hyperplasia: report of an autopsy case　M. H. Sasaki, Y.;Nakanuma, Y.　J Gastroenterol Hepatol　21　12　1866-8　2006
　Lipopolysaccharide induces overexpression of MUC2 and MUC5AC in cultured biliary epithelial cells: possible key phenomenon of hepatolithiasis　Y. H. Zen, K.;Sasaki, M.;Tsuneyama, K.;Katayanagi, K.;Yamamoto, Y.;Nakanuma, Y.　Am J Pathol　161　4　1475-84　2002
　Aberrant expression of CDX2 is closely related to the intestinal metaplasia and MUC2 expression in intraductal papillary neoplasm of the liver in hepatolithiasis　A. S. Ishikawa, M.;Ohira, S.;Ohta, T.;Oda, K.;Nimura, Y.;Chen, M. F.;Jan, Y. Y.;Yeh, T. S.;Nakanuma, Y.　Lab Invest　84　5　629-38　2004
　IgG4-related sclerosing cholangitis with and without hepatic inflammatory pseudotumor, and sclerosing pancreatitis-associated sclerosing cholangitis: do they belong to a spectrum of sclerosing pancreatitis?　Y. H. Zen, K.;Sasaki, M.;Sato, Y.;Tsuneyama, K.;Haratake, J.;Kurumaya, H.;Katayanagi, K.;Masuda, S.;Niwa, H.;Morimoto, H.;Miwa, A.;Uchiyama, A.;Portmann, B. C.;Nakanuma, Y.　Am J Surg Pathol　28　9　1193-203　2004
　Proposal of histological criteria for intraepithelial atypical/proliferative biliary epithelial lesions of the bile duct in hepatolithiasis with respect to cholangiocarcinoma: preliminary report based on interobserver agreement　Y. A. Zen, S.;Ajioka, Y.;Haratake, J.;Kage, M.;Kondo, F.;Nimura, Y.;Sakamoto, M.;Sasaki, M.;Shimamatsu, K.;Wakasa, K.;Park, Y. N.;Chen, M. F.;Atomi, Y.;Nakanuma, Y.　Pathol Int　55　4　180-8　2005
　Augmented expression of hepatocytes growth factor activator inhibitor type 1 (HAI-1) in intrahepatic small bile ducts in primary biliary cirrhosis　M. I. Sasaki, H.;Kataoka, H.;Nakanuma, Y.　Virchows Arch　449　4　462-71　2006
　Immunohistochemical analysis of cell-matrix adhesion molecules and their ligands in the portal tracts of primary biliary cirrhosis　M. T. Yasoshima, K.;Harada, K.;Sasaki, M.;Gershwin, M. E.;Nakanuma, Y.　J Pathol　190　1　34213　2000
　Decreased expression of Bmi1 is closely associated with cellular senescence in small bile ducts in primary biliary cirrhosis　M. I. Sasaki, H.;Sato, Y.;Nakanuma, Y.　Am J Pathol　169　3　831-45　2006
　Expression of MUC1 and MUC2 and carbohydrate antigen Tn change during malignant transformation of biliary papillomatosis　S. S. Amaya, M.;Watanabe, Y.;Tsui, W. M.;Tsuneyama, K.;Harada, K.;Nakanuma, Y.　Histopathology　38　6　550-60　2001
　Frequent expression of mucin core protein MUC1 in non-neoplastic gallbladder mucosa from patients with pancreaticobiliary maljunction　T. K. Yamato, H.;Ohama, K.;Yamamichi, N.;Watanabe, Y.;Harada, K.;Sasaki, M.;Nakanuma, Y.　Liver　19　4　281-7　1999
　Histopathology of the liver in non-cirrhotic portal hypertension of unknown aetiology　Y. H. Nakanuma, M.;Sasaki, M.;Terada, T.;Katayanagi, K.;Nonomura, A.;Kurumaya, H.;Harada, A.;Obata, H.　Histopathology　28　3　195-204　1996
　Hepatitic bile duct injuries in chronic hepatitis C: histopathologic and immunohistochemical studies　K. N. Kaji, Y.;Sasaki, M.;Unoura, M.;Kobayashi, K.;Nonomura, A.;Tsuneyama, K.;Van de Water, J.;Gershwin, M. E.　Mod Pathol　7　9　937-45　1994
　Immunoglobulin gene usage and immunohistochemical characteristics of human monoclonal antibodies to the mitochondrial autoantigens of primary biliary cirrhosis induced in the XenoMouse　M. V. D. W. Sasaki, J.;Kenny, T. P.;Gallo, M. L.;Leung, P. S.;Nakanuma, Y.;Ansari, A. A.;Coppel, R. L.;Neuberger, J.;Gershwin, M. E.　Hepatology　34　4 Pt 1　631-7　2001
　Modulation of the microenvironment by senescent biliary epithelial cells may be involved in the pathogenesis of primary biliary cirrhosis　M. M. Sasaki, M.;Sato, Y.;Nakanuma, Y.　J Hepatol　53　2　318-25　2010
　Primary localized malignant biphasic mesothelioma of the liver in a patient with asbestosis　M. A. Sasaki, I.;Yasui, T.;Kinoshita, M.;Itatsu, K.;Nojima, T.;Nakanuma, Y.　World J Gastroenterol　15　5　615-21　2009
　Multistep carcinogenesis of perihilar cholangiocarcinoma arising in the intrahepatic large bile ducts　Y. S. Nakanuma, M.;Sato, Y.;Ren, X.;Ikeda, H.;Harada, K.　World J Hepatol　1　1　35-42　2009
　Endothelial to mesenchymal transition via transforming growth factor-beta1/Smad activation is associated with portal venous stenosis in idiopathic portal hypertension　A. S. Kitao, Y.;Sawada-Kitamura, S.;Harada, K.;Sasaki, M.;Morikawa, H.;Shiomi, S.;Honda, M.;Matsui, O.;Nakanuma, Y.　Am J Pathol　175　2　616-26　2009
　Biliary epithelial apoptosis, autophagy, and senescence in primary biliary cirrhosis　M. N. Sasaki, Y.　Hepat Res Treat　2010　205128　2010
　Cyclooxygenase-2 is involved in the up-regulation of matrix metalloproteinase-9 in cholangiocarcinoma induced by tumor necrosis factor-alpha　K. S. Itatsu, M.;Yamaguchi, J.;Ohira, S.;Ishikawa, A.;Ikeda, H.;Sato, Y.;Harada, K.;Zen, Y.;Sato, H.;Ohta, T.;Nagino, M.;Nimura, Y.;Nakanuma, Y.　Am J Pathol　174　3　829-41　2009
　Large cell change of hepatocytes in chronic viral hepatitis represents a senescent-related lesion　H. S. Ikeda, M.;Sato, Y.;Harada, K.;Zen, Y.;Mitsui, T.;Nakanuma, Y.　Hum Pathol　40　12　1774-82　2009
　Bile ductular cell reaction with senescent hepatocytes in chronic viral hepatitis is lost during hepatocarcinogenesis　H. S. Ikeda, M.;Sato, Y.;Harada, K.;Zen, Y.;Mitsui, T.;Nakanuma, Y.　Pathol Int　59　7　471-8　2009
　Over-expression of polycomb group protein EZH2 relates to decreased expression of p16 INK4a in cholangiocarcinogenesis in hepatolithiasis　M. Y. Sasaki, J.;Itatsu, K.;Ikeda, H.;Nakanuma, Y.　J Pathol　215　2　175-83　2008
　Histone deacetylase inhibitor (SAHA) and repression of EZH2 synergistically inhibit proliferation of gallbladder carcinoma　J. S. Yamaguchi, M.;Sato, Y.;Itatsu, K.;Harada, K.;Zen, Y.;Ikeda, H.;Nimura, Y.;Nagino, M.;Nakanuma, Y.　Cancer Sci　101　2　355-62　2010
　The overexpression of polycomb group proteins Bmi1 and EZH2 is associated with the progression and aggressive biological behavior of hepatocellular carcinoma　M. I. Sasaki, H.;Itatsu, K.;Yamaguchi, J.;Sawada, S.;Minato, H.;Ohta, T.;Nakanuma, Y.　Lab Invest　88　8　873-82　2008
　Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mito-inhibitory p21WAF1/Cip1 in chronic non-suppurative destructive cholangitis in primary biliary cirrhosis: an immunohistochemical study　M. I. Sasaki, H.;Nakanuma, Y.　J Autoimmun　31　1　26877　2008
　Significance of enhanced expression of nitric oxide syntheses in splenic sinus lining cells in altered portal hemodynamics of idiopathic portal hypertension　Y. S. Sato, S.;Kozaka, K.;Harada, K.;Sasaki, M.;Matsui, O.;Nakanuma, Y.　Dig Dis Sci　52　8　1987-94　2007
　Cholangiocytes with mesenchymal features contribute to progressive hepatic fibrosis of the polycystic kidney rat　Y. H. Sato, K.;Ozaki, S.;Furubo, S.;Kizawa, K.;Sanzen, T.;Yasoshima, M.;Ikeda, H.;Sasaki, M.;Nakanuma, Y.　Am J Pathol　171　6　1859-71　2007
　Expression profiles of MUC mucins and trefoil factor family (TFF) peptides in the intrahepatic biliary system: physiological distribution and pathological significance　M. I. Sasaki, H.;Nakanuma, Y.　Prog Histochem Cytochem　42　2　61-110　2007
　Flare-up of nonalcoholic steatohepatitis after hepatectomy resulted in hepatic failure in a patient with type 2 diabetes mellitus　M. I. Sasaki, K.;Minato, H.;Takamura, H.;Ohta, T.;Nakanuma, Y.　Dig Dis Sci　52　12　574680　2007
　Liver steatosis, but not fibrosis, is associated with insulin resistance in nonalcoholic fatty liver disease　M. T. Sakurai, T.;Ota, T.;Ando, H.;Akahori, H.;Kaji, K.;Sasaki, M.;Nakanuma, Y.;Miura, K.;Kaneko, S.　J Gastroenterol　42　4　312-7　2007
　Clinicopathological significance of antinuclear antibodies in non-alcoholic steatohepatitis　H. S. Niwa, M.;Haratake, J.;Kasai, T.;Katayanagi, K.;Kurumaya, H.;Masuda, S.;Minato, H.;Zen, Y.;Uchiyama, A.;Miwa, A.;Saito, K.;Sudo, Y.;Nakanuma, Y.　Hepatol Res　37　11　923-31　2007
　Naturally-occurring regulatory T cells are increased in inflamed portal tracts with cholangiopathy in primary biliary cirrhosis　M. I. Sasaki, H.;Sawada, S.;Sato, Y.;Nakanuma, Y.　J Clin Pathol　60　10　1102-7　2007
　Clinicopathological significance of S100 protein expression in cholangiocarcinoma　Y. H. Sato, K.;Sasaki, M.;Nakanuma, Y.　J Gastroenterol Hepatol　28　8　1422-9　2013
　Serum amyloid A-positive hepatocellular neoplasms may be a hitherto-unrecognized type of inflammatory hepatocellular tumor arising in advanced alcoholic liver disease　Sasaki, Motoko;Yoneda, Norihide;Sato, Yasunori;Nakanuma, Yasuni　HEPATOLOGY　56　0　467A-467A　2012
　Intraepithelial infiltration of ORM1-like protein 3 (ORMDL3) -expressing cells may be closely related to the pathogenesis of primary biliary cirrhosis　Sasaki, Motoko;Miyakoshi, Masami;Sato, Yasunori;Nakanuma, Yasuni　HEPATOLOGY　56　0　1139A-1140A　2012
　Validation of a new histological staging and grading system for primary biliary cirrhosis in comparison with classical systems　Kakuda, Yuko;Harada, Kenichi;Sawada-Kitamura, Seiko;Ikeda, Hiroko;Sato, Yasunori;Sasaki, Motoko;Nakanuma, Yasuni　HEPATOLOGY　56　0　1141A-1141A　2012
　Clinicopathologic Significance of Combined Hepatocellular-Cholangiocarcinoma With Stem Cell Subtype Components With Reference to the Expression of Putative Stem Cell Markers　Ikeda, Hiroko;Harada, Kenichi;Sato, Yasunori;Sasaki, Motoko;Yoneda, Non Hide;Kitamura, Seiko;Sudo, Yoshiko;Ooi, Akishi;Nakanuma, Yasuni　AMERICAN JOURNAL OF CLINICAL PATHOLOGY　140　3　329-340　2013　
　Adenovirus pneumonia presenting with nodular shadows on chest X-ray in two unrelated allogeneic bone marrow transplant recipients　Mochizuki, Kanako; Kondo, Yukio; Hosokawa, Kohei; Ohata, Kinya; Yamazaki, Hirohito; Takami, Akiyoshi; Sasaki, Motoko; Sato, Yasunori; Nakanuma, Yasuni; Nakao, Shinji　Internal Medicine　53　5　499-503　2014/01/01　
　Histological course of nonalcoholic fatty liver disease in Japanese patients: tight glycemic control, rather than weight reduction, ameliorates liver fibrosis　E. T. Hamaguchi, T.;Sakurai, M.;Mizukoshi, E.;Zen, Y.;Takeshita, Y.;Kurita, S.;Arai, K.;Yamashita, T.;Sasaki, M.;Nakanuma, Y.;Kaneko, S.　Diabetes Care　33　2　284-6　2010
　A subgroup of intrahepatic cholangiocarcinoma with an infiltrating replacement growth pattern and a resemblance to reactive proliferating bile ductules: 'bile ductular carcinoma'　K. S. Kozaka, M.;Fujii, T.;Harada, K.;Zen, Y.;Sato, Y.;Sawada, S.;Minato, H.;Matsui, O.;Nakanuma, Y.　Histopathology　51　3　390-400　2007
　Autophagy may occur at an early stage of cholangiocarcinogenesis via biliary intraepithelial neoplasia　Sasaki, Motoko;Nitta, Takeo;Sato, Yasunori;Nakanuma, Yasuni　HUMAN PATHOLOGY　46　2　202-209　2015/01/01　
　Polycomb group protein Bmi1 is overexpressed and essential in anchorage-independent colony formation, cell proliferation and repression of cellular senescence in cholangiocarcinoma: tissue and culture studies　M. Y. Sasaki, J.;Ikeda, H.;Itatsu, K.;Nakanuma, Y.　Hum Pathol　40　12　1723-30　2009
　Phosphorylation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase and nuclear translocation of nuclear factor-kappaB are involved in upregulation of matrix metalloproteinase-9 by tumour necrosis factor-alpha　K. S. Itatsu, M.;Harada, K.;Yamaguchi, J.;Ikeda, H.;Sato, Y.;Ohta, T.;Sato, H.;Nagino, M.;Nimura, Y.;Nakanuma, Y.　Liver Int　29　2　291-8　2009
　Hepatic stellate cells are activated around central scars of focal nodular hyperplasia of the liver--a potential mechanism of central scar formation　Y. H. Sato, K.;Ikeda, H.;Fijii, T.;Sasaki, M.;Zen, Y.;Nakanuma, Y.　Hum Pathol　40　2　181-8　2009
　Intraductal papillary-mucinous neoplasm of the pancreas associated with polycystic liver and kidney disease　Y. M. Sato, M.;Sasaki, M.;Kitao, A.;Yoneda, N.;Kobayashi, D.;Imamura, Y.;Nakanuma, Y.　Pathol Int　59　3　201-4　2009
　Papillary hyperplasia of the gallbladder in pancreaticobiliary maljunction represents a senescence-related lesion induced by lysolecithin　J. S. Yamaguchi, M.;Harada, K.;Zen, Y.;Sato, Y.;Ikeda, H.;Itatsu, K.;Yokoyama, Y.;Ando, H.;Ohta, T.;Kubota, A.;Shimizu, K.;Nimura, Y.;Nagino, M.;Nakanuma, Y.　Lab Invest　89　9　1018-31　2009
　Pathological classification of intrahepatic cholangiocarcinoma based on a new concept　Y. S. Nakanuma, Y.;Harada, K.;Sasaki, M.;Xu, J.;Ikeda, H.　World J Hepatol　2　12　419-27　2010
　Adenovirus pneumonia presenting with nodular shadows on chest X-ray in two unrelated allogeneic bone marrow transplant recipients　K. K. Mochizuki, Y.;Hosokawa, K.;Ohata, K.;Yamazaki, H.;Takami, A.;Sasaki, M.;Sato, Y.;Nakanuma, Y.;Nakao, S.　Intern Med　53　5　499-503　2014
　Bile ductular cells undergoing cellular senescence increase in chronic liver diseases along with fibrous progression　M. I. Sasaki, H.;Yamaguchi, J.;Miyakoshi, M.;Sato, Y.;Nakanuma, Y.　Am J Clin Pathol　133　2　212-23　2010
　Tumorigenesis and phenotypic characteristics of mucin-producing bile duct tumors: an immunohistochemical approach　Y. Z. Nakanuma, Y.;Harada, K.;Ikeda, H.;Sato, Y.;Uehara, T.;Sasaki, M.　J Hepatobiliary Pancreat Sci　17　3　211-22　2010
　A Case of Hypereosinophilia-Associated Multiple Mass Lesions of Liver Showing Non-Granulomatous Eosinophilic Hepatic Necrosis　H. K. Ikeda, K.;Kurumaya, H.;Harada, K.;Sato, Y.;Sasaki, M.;Nakanuma, Y.　Gastroenterology Res　4　4　168-173　2011
　Application of a new histological staging and grading system for primary biliary cirrhosis to liver biopsy specimens: Interobserver agreement　Y. Z. Nakanuma, Y.;Harada, K.;Sasaki, M.;Nonomura, A.;Uehara, T.;Sano, K.;Kondo, F.;Fukusato, T.;Tsuneyama, K.;Ito, M.;Wakasa, K.;Nomoto, M.;Minato, H.;Haga, H.;Kage, M.;Yano, H.;Haratake, J.;Aishima, S.;Masuda, T.;Aoyama, H.;Miyakawa-Hayashino, A.;Matsumoto, T.;Sanefuji, H.;Ojima, H.;Chen, T. C.;Yu, E.;Kim, J. H.;Park, Y. N.;Tsui, W.　Pathol Int　60　3　167-74　2010
　Evaluation of a new histologic staging and grading system for primary biliary cirrhosis in comparison with classical systems　Y. H. Kakuda, K.;Sawada-Kitamura, S.;Ikeda, H.;Sato, Y.;Sasaki, M.;Okafuji, H.;Mizukoshi, E.;Terasaki, S.;Ohta, H.;Kasashima, S.;Kawashima, A.;Kaizaki, Y.;Kaneko, S.;Nakanuma, Y.　Hum Pathol　44　6　1107-17　2013
　Autophagy may precede cellular senescence of bile ductular cells in ductular reaction in primary biliary cirrhosis　M. M. Sasaki, M.;Sato, Y.;Nakanuma, Y.　Dig Dis Sci　57　3　660-6　2012
　KRAS and GNAS mutations and p53 overexpression in biliary intraepithelial neoplasia and intrahepatic cholangiocarcinomas　M. S. Hsu, M.;Igarashi, S.;Sato, Y.;Nakanuma, Y.　Cancer　119　9　1669-74　2013
　Association of interleukin-28B genotype and hepatocellular carcinoma recurrence in patients with chronic hepatitis C　Y. H. Hodo, M.;Tanaka, A.;Nomura, Y.;Arai, K.;Yamashita, T.;Sakai, Y.;Yamashita, T.;Mizukoshi, E.;Sakai, A.;Sasaki, M.;Nakanuma, Y.;Moriyama, M.;Kaneko, S.　Clin Cancer Res　19　7　1827-37　2013
　Hilar cholangiocarcinoma and pancreatic ductal adenocarcinoma share similar histopathologies, immunophenotypes, and development-related molecules　C. H. Gandou, K.;Sato, Y.;Igarashi, S.;Sasaki, M.;Ikeda, H.;Nakanuma, Y.　Hum Pathol　44　5　811-21　2013
　Beta-catenin-activated hepatocellular adenoma showing hyperintensity on hepatobiliary-phase gadoxetic-enhanced magnetic resonance imaging and overexpression of OATP8　N. M. Yoneda, O.;Kitao, A.;Kozaka, K.;Gabata, T.;Sasaki, M.;Nakanuma, Y.;Murata, K.;Tani, T.　Jpn J Radiol　30　9　777-82　2012
　Intrahepatic cholangiocarcinomas in cirrhosis are hypervascular in comparison with those in normal livers　J. I. Xu, S.;Sasaki, M.;Matsubara, T.;Yoneda, N.;Kozaka, K.;Ikeda, H.;Kim, J.;Yu, E.;Matsui, O.;Nakanuma, Y.　Liver Int　32　7　1156-64　2012
　GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase　M. A. T. Sakr, T.;Domoto, T.;Nakano, H.;Wong, R. W.;Sasaki, M.;Nakanuma, Y.;Sato, H.　Cancer Sci　101　11　2368-74　2010
　Metachronous intracystic and intraductal papillary neoplasms of the biliary tree　H. S. Sato, Y.;Harada, K.;Sasaki, M.;Hirano, K.;Nakanuma, Y.　World J Gastroenterol　19　36　1543303　2013
　Histological characteristics of biliary intraepithelial neoplasia-3 and intraepithelial spread of cholangiocarcinoma　Y. H. Sato, K.;Sasaki, M.;Nakanuma, Y.　Virchows Arch　462　4　421-7　2013
　Pathological spectrum of intrahepatic cholangiocarcinoma arising in non-biliary chronic advanced liver diseases　Y. X. Nakanuma, J.;Harada, K.;Sato, Y.;Sasaki, M.;Ikeda, H.;Kim, J.;Yu, E.　Pathol Int　61　5　298-305　2011
　Participation of bile ductular cells in the pathological progression of non-alcoholic fatty liver disease　M. S. Chiba, M.;Kitamura, S.;Ikeda, H.;Sato, Y.;Nakanuma, Y.　J Clin Pathol　64　7　564-70　2011
　Novel approach to bile duct damage in primary biliary cirrhosis: participation of cellular senescence and autophagy　M. N. Sasaki, Y.　Int J Hepatol　2012　452143　2012
　Intraductal tubular neoplasm of the common bile duct　Y. O. Sato, H.;Harada, K.;Sasaki, M.;Nakanuma, Y.　Pathol Int　60　7　516-9　2010
　Epithelial-mesenchymal transition induced by transforming growth factor-{beta}1/Snail activation aggravates invasive growth of cholangiocarcinoma　Y. H. Sato, K.;Itatsu, K.;Ikeda, H.;Kakuda, Y.;Shimomura, S.;Shan Ren, X.;Yoneda, N.;Sasaki, M.;Nakanuma, Y.　Am J Pathol　177　1　141-52　2010
　Autophagy mediates the process of cellular senescence characterizing bile duct damages in primary biliary cirrhosis　M. M. Sasaki, M.;Sato, Y.;Nakanuma, Y.　Lab Invest　90　6　835-43　2010
　Loss of ARID1A Expression Presents a Novel Pathway of Carcinogenesis in Biliary Carcinomas　M. N. Sasaki, T.;Sato, Y.;Nakanuma, Y.　Am J Clin Pathol　145　6　815-25　2016
　Altered intrahepatic microcirculation of idiopathic portal hypertension in relation to glutamine synthetase expression　Y. H. Sato, K.;Sasaki, M.;Nakanuma, Y.　Hepatol Res　45　13　1323-30　2015
　Mutational landscape of combined hepatocellular carcinoma and cholangiocarcinoma, and its clinicopathological significance　M. S. Sasaki, Y.;Nakanuma, Y.　Histopathology　70　3　423-434　2017/03/01
　EFFECTS OF MTOR INHIBITORS ON THE BILIARY DYSGENESIS OF THE PCK RAT, AN ANIMAL MODEL OF CAROLI'S DISEASE　Sato, Yasunori;Ren, Xiang Shan;Harada, Kenichi;Sasaki, Motoko;Nakanuma, Yasuni　HEPATOLOGY　54　0　767A-767A　2011
　Pathological spectrum of intrahepatic cholangiocarcinoma arising in non-biliary chronic advanced liver diseases　Nakanuma, Yasuni;Xu, Jing;Harada, Kenichi;Sato, Yasunori;Sasaki, Motoko;Ikeda, Hiroko;Kim, Jihun;Yu, Eunsil　PATHOLOGY INTERNATIONAL　61　5　298-305　2011
　Perihilar cholangiocarcinoma and pancreatic ductal adenocarcinoma share similar histopathologies, immunophenotypes and development-related molecules: a suggestion of a common carcinogenetic process　Sato, Yasunori;Gandou, Chihiro;Harada, Kenichi;Sasaki, Motoko;Nakanuma, Yasuni　HEPATOLOGY　56　0　620A-620A　2012
　Bile Acids and Deregulated Cholangiocyte Autophagy in Primary Biliary Cholangitis　Sasaki M, Nakanuma Y　Dig Dis　35　3　210-216　2017/03/01
　Stress-induced cellular responses and cell death mechanisms during inflammatory cholangiopathies　Sasaki M, Nakanuma Y　Clin Res Hepatol Gastroenterol　41　2　129-138　2017/02/01
　Benign Hepatocellular Nodules: Hepatobiliary Phase of Gadoxetic Acid-enhanced MR Imaging Based on Molecular Background　N. M. Yoneda, O.;Kitao, A.;Kozaka, K.;Kobayashi, S.;Sasaki, M.;Yoshida, K.;Inoue, D.;Minami, T.;Gabata, T.　Radiographics　36　7　2010-2027　2016
　New concept: cellular senescence in pathophysiology of cholangiocarcinoma　M. N. Sasaki, Y.　Expert Rev Gastroenterol Hepatol　10　5　625-38　2016
　Characterization of intraductal papillary neoplasm of bile duct with respect to histopathologic similarities to pancreatic intraductal papillary mucinous neoplasm　Y. K. Nakanuma, Y.;Uesaka, K.;Miyata, T.;Yamamoto, Y.;Fukumura, Y.;Sato, Y.;Sasaki, M.;Harada, K.;Takase, M.　Hum Pathol　51　103-13　2016
　Clinicopathological significance of 'subtypes with stem-cell feature' in combined hepatocellular-cholangiocarcinoma　M. S. Sasaki, H.;Kakuda, Y.;Sato, Y.;Choi, J. H.;Nakanuma, Y.　Liver Int　35　3　1024-35　2015
　Cellular senescence in biliary pathology. Special emphasis on expression of a polycomb group protein EZH2 and a senescent marker p16INK4a in bile ductular tumors and lesions　M. N. Sasaki, Y.　Histol Histopathol　30　3　267-75　2015
　Pathological diagnosis of flat epithelial lesions of the biliary tract with emphasis on biliary intraepithelial neoplasia　Y. S. Sato, M.;Harada, K.;Aishima, S.;Fukusato, T.;Ojima, H.;Kanai, Y.;Kage, M.;Nakanuma, Y.;Tsubouchi, H.;Hepatolithiasis Subdivision of Intractable Hepatobiliary Diseases Study Group of, Japan　J Gastroenterol　49　1　64-72　2014
　A case of mucinous cystic neoplasm of the liver: description of Sonazoid-enhanced ultrasound imaging and histopathologic findings　K. M. Sugimoto, F.;Kono, S.;Sasaki, M.;Nakanuma, Y.;Imai, Y.　J Med Ultrason (2001)　40　3　243-50　2013
　Serum amyloid A-positive hepatocellular neoplasms in the resected livers from 3 patients with alcoholic cirrhosis　M. K. Sasaki, F.;Sawai, Y.;Imai, Y.;Kadowaki, S.;Sano, K.;Fukusato, T.;Matsui, O.;Nakanuma, Y.　Histol Histopathol　28　11　1499-505　2013
　Induction of elastin expression in vascular endothelial cells relates to hepatoportal sclerosis in idiopathic portal hypertension: possible link to serum anti-endothelial cell antibodies　Y. R. Sato, X. S.;Harada, K.;Sasaki, M.;Morikawa, H.;Shiomi, S.;Honda, M.;Kaneko, S.;Nakanuma, Y.　Clin Exp Immunol　167　3　532-42　2012
　Heat shock proteins 27 and 70 are potential biliary markers for the detection of cholangiocarcinoma　Y. H. Sato, K.;Sasaki, M.;Yasaka, T.;Nakanuma, Y.　Am J Pathol　180　1　123-30　2012
　A serum amyloid A-positive hepatocellular neoplasm arising in alcoholic cirrhosis: a previously unrecognized type of inflammatory hepatocellular tumor　M. Y. Sasaki, N.;Kitamura, S.;Sato, Y.;Nakanuma, Y.　Mod Pathol　25　12　1584-93　2012
　Overview of hepatocellular adenoma in Japan　M. N. Sasaki, Y.　Int J Hepatol　2012　648131　2012
　Immunohistochemical characteristics and malignant progression of hepatic cystic neoplasms in comparison with pancreatic counterparts　T. S. Matsubara, Y.;Sasaki, M.;Harada, K.;Nomoto, K.;Tsuneyama, K.;Nakamura, K.;Gabata, T.;Matsui, O.;Nakanuma, Y.　Hum Pathol　43　12　2177-86　2012
　Frequent p16ink4a inactivation is an early and frequent event of intraductal papillary neoplasm of the liver arising in hepatolithiasis.　HUMAN PATHOLOGY　35　12　1505-1514　2004/12
　Intrahepatic cholangiocarcinoma escapes from growth inhibitory effect of transforming growth factor-beta1 by overexpression of cyclin D1　LABORATORY INVESTIGATION　85　4　572-581　2005/04
　A possible involvement of endoplasmic reticulum stress in biliary epithelial autophagy and senescence in primary biliary cirrhosis　M. Y.-M. Sasaki, M.;Sato, Y.;Nakanuma, Y.　J Gastroenterol　50　9　984-95　2015
　Clinicopathological characteristics of serum amyloid A-positive hepatocellular neoplasms/nodules arising in alcoholic cirrhosis　M. Y. Sasaki, N.;Sawai, Y.;Imai, Y.;Kondo, F.;Fukusato, T.;Yoshikawa, S.;Kobayashi, S.;Sato, Y.;Matsui, O.;Nakanuma, Y.　Histopathology　66　6　836-45　2015
　Serum Amyloid A-Positive Hepatocellular Neoplasm: A New Type of Tumor Arising in Patients with Advanced Alcoholic Disease　M. N. Sasaki, Y.　Dig Dis　33　5　648-54　2015
　Autophagy may occur at an early stage of cholangiocarcinogenesis via biliary intraepithelial neoplasia　M. N. Sasaki, T.;Sato, Y.;Nakanuma, Y.　Hum Pathol　46　2　202-9　2015
　In recurrent primary biliary cirrhosis after liver transplantation, biliary epithelial cells show increased expression of mitochondrial proteins　M. H. Sasaki, M.;Yeh, M. M.;Nakanuma, Y.　Virchows Arch　467　4　417-25　2015
　Autophagy and senescence in fibrosing cholangiopathies　Y. S. Nakanuma, M.;Harada, K.　J Hepatol　62　4　934-45　2015
　Autophagy may promote carcinoma cell invasion and correlate with poor prognosis in cholangiocarcinoma　T. S. Nitta, Y.;Ren, X. S.;Harada, K.;Sasaki, M.;Hirano, S.;Nakanuma, Y.　Int J Clin Exp Pathol　7　8　4913-21　2014
　What are the precursor and early lesions of peripheral intrahepatic cholangiocarcinoma?　Y. T. Nakanuma, A.;Ren, X. S.;Harada, K.;Sato, Y.;Sasaki, M.　Int J Hepatol　2014　805973　2014
　Proposal of a new disease concept "biliary diseases with pancreatic counterparts". Anatomical and pathological bases　Y. H. Nakanuma, K.;Sasaki, M.;Sato, Y.　Histol Histopathol　29　1　42745　2014
　Clinicopathological study of primary biliary cirrhosis with interface hepatitis compared to autoimmune hepatitis　M. K. Kobayashi, Y.;Harada, K.;Sato, Y.;Sasaki, M.;Ikeda, H.;Terada, M.;Mukai, M.;Kaneko, S.;Nakanuma, Y.　World J Gastroenterol　20　13　3597-608　2014
　Multiple hypervascular FNH-like lesions in a patient with no history of alcohol abuse or chronic liver disease　J. M. Tani, H.;Sasaki, M.;Nakanuma, Y.;Nomura, T.;Yoneyama, H.;Morishita, A.;Kobara, H.;Hirohito, M.;Himoto, T.;Masaki, T.　Intern Med　52　19　2225-30　2013
　Clinicopathologic significance of combined hepatocellular-cholangiocarcinoma with stem cell subtype components with reference to the expression of putative stem cell markers　H. H. Ikeda, K.;Sato, Y.;Sasaki, M.;Yoneda, N.;Kitamura, S.;Sudo, Y.;Ooi, A.;Nakanuma, Y.　Am J Clin Pathol　140　3　329-40　2013
　Participation of peribiliary glands in biliary tract pathophysiologies　S. S. Igarashi, Y.;Ren, X. S.;Harada, K.;Sasaki, M.;Nakanuma, Y.　World J Hepatol　5　8　425-32　2013
　A possible involvement of p62/sequestosome-1 in the process of biliary epithelial autophagy and senescence in primary biliary cirrhosis　M. M. Sasaki, M.;Sato, Y.;Nakanuma, Y.　Liver Int　32　3　487-99　2012
　Biliary adenofibroma with ominous features of imminent malignant changes　A. B. Tsutsui, Y.;Sato, Y.;Miyake, H.;Sawada-Kitamura, S.;Shibata, H.;Kakuda, Y.;Harada, K.;Sasaki, M.;Nakanuma, Y.　Clin J Gastroenterol　7　5　441-8　2014
　alpha-Fetoprotein-producing gastric carcinoma and combined hepatocellular and cholangiocarcinoma show similar morphology but different histogenesis with respect to SALL4 expression　H. S. Ikeda, Y.;Yoneda, N.;Harada, K.;Sasaki, M.;Kitamura, S.;Sudo, Y.;Ooi, A.;Nakanuma, Y.　Hum Pathol　43　11　1955-63　2012
　Bile duct expression of pancreatic and duodenal homeobox 1 in perihilar cholangiocarcinogenesis　S. M. Igarashi, T.;Harada, K.;Ikeda, H.;Sato, Y.;Sasaki, M.;Matsui, O.;Nakanuma, Y.　Histopathology　61　2　266-76　2012
　Epidermal growth factor induces cytokeratin 19 expression accompanied by increased growth abilities in human hepatocellular carcinoma　N. S. Yoneda, Y.;Kitao, A.;Ikeda, H.;Sawada-Kitamura, S.;Miyakoshi, M.;Harada, K.;Sasaki, M.;Matsui, O.;Nakanuma, Y.　Lab Invest　91　2　262-72　2011
　Intrahepatic cholangiocarcinoma arising in chronic advanced liver disease and the cholangiocarcinomatous component of hepatocellular cholangiocarcinoma share common phenotypes and cholangiocarcinogenesis　J. S. Xu, M.;Harada, K.;Sato, Y.;Ikeda, H.;Kim, J. H.;Yu, E.;Nakanuma, Y.　Histopathology　59　6　1090-9　2011
　Characterization of hepatocellular adenoma based on the phenotypic classification: The Kanazawa experience　M. Y. Sasaki, N.;Kitamura, S.;Sato, Y.;Nakanuma, Y.　Hepatol Res　41　10　982-8　2011
　Biliary infection may exacerbate biliary cystogenesis through the induction of VEGF in cholangiocytes of the polycystic kidney (PCK) rat　X. S. S. Ren, Y.;Harada, K.;Sasaki, M.;Yoneda, N.;Lin, Z. H.;Nakanuma, Y.　Am J Pathol　179　6　2845-54　2011
　Proinflammatory cytokine-induced cellular senescence of biliary epithelial cells is mediated via oxidative stress and activation of ATM pathway: a culture study　M. I. Sasaki, H.;Sato, Y.;Nakanuma, Y.　Free Radic Res　42　7　625-32　2008
　Regulation of adiponectin receptor expression in human liver and a hepatocyte cell line　A. T. Shimizu, T.;Matsuzawa, N.;Nakamura, S.;Nabemoto, S.;Takeshita, Y.;Misu, H.;Kurita, S.;Sakurai, M.;Yokoyama, M.;Zen, Y.;Sasaki, M.;Nakanuma, Y.;Kaneko, S.　Metabolism　56　11　1478-85　2007
　Involvement of Escherichia coli in pathogenesis of xanthogranulomatous cholecystitis with scavenger receptor class A and CXCL16-CXCR6 interaction　S. H. Sawada, K.;Isse, K.;Sato, Y.;Sasaki, M.;Kaizaki, Y.;Nakanuma, Y.　Pathol Int　57　10　652-63　2007
　Different carcinogenic process in cholangiocarcinoma cases epidemically developing among workers of a printing company in Japan　Y. K. Sato, S.;Takemura, S.;Sugawara, Y.;Tanaka, S.;Fujikawa, M.;Arimoto, A.;Harada, K.;Sasaki, M.;Nakanuma, Y.　Int J Clin Exp Pathol　7　8　4745-54　2014
　Histological Characterization of Biliary Intraepithelial Neoplasia with respect to Pancreatic Intraepithelial Neoplasia　Y. H. Sato, K.;Sasaki, M.;Nakanuma, Y.　Int J Hepatol　2014　678260　2014
　Cystic and micropapillary epithelial changes of peribiliary glands might represent a precursor lesion of biliary epithelial neoplasms　Y. H. Sato, K.;Sasaki, M.;Nakanuma, Y.　Virchows Arch　464　2　157-63　2014
　Immunostaining for polycomb group protein EZH2 and senescent marker p16INK4a may be useful to differentiate cholangiolocellular carcinoma from ductular reaction and bile duct adenoma　M. M. Sasaki, T.;Kakuda, Y.;Sato, Y.;Nakanuma, Y.　Am J Surg Pathol　38　3　364-9　2014
　Chemokine-chemokine receptor CCL2-CCR2 and CX3CL1-CX3CR1 axis may play a role in the aggravated inflammation in primary biliary cirrhosis　M. M. Sasaki, M.;Sato, Y.;Nakanuma, Y.　Dig Dis Sci　59　2　358-64　2014
　Infiltration of inflammatory cells expressing mitochondrial proteins around bile ducts and in biliary epithelial layer may be involved in the pathogenesis in primary biliary cirrhosis　M. K. Sasaki, Y.;Miyakoshi, M.;Sato, Y.;Nakanuma, Y.　J Clin Pathol　67　6　470-6　2014
　Hyperplastic hepatocellular nodule with localized hemangiomatosis: A hither-to unrecognized type of hypervascular hepatic lesion　M. I. Sasaki, T.;Hatanaka, K. C.;Nakanuma, Y.　Hepatol Res　44　10　E77-83　2014
　Activation of the PI3K/mTOR pathway is involved in cystic proliferation of cholangiocytes of the PCK rat　X. S. S. Ren, Y.;Harada, K.;Sasaki, M.;Furubo, S.;Song, J. Y.;Nakanuma, Y.　PLoS One　9　1　e87660　2014
　GNAS and KRAS mutations are common in intraductal papillary neoplasms of the bile duct　M. M. Sasaki, T.;Nitta, T.;Sato, Y.;Nakanuma, Y.　PLoS One　8　12　e81706　2013
　Chemokines CCL2 and CX3CL1 as senescence-associated secretory phenotypes may play a role in aggravated inflammation in primary biliary cirrhosis　Sasaki, Motoko;Miyakoshi, Masami;Sato, Yasunori;Nakanuma, Yasuni　HEPATOLOGY　56　0　1135A-1136A　2012
　Overexpression of enhancer of zeste homolog 2 and MUC1 may be related to malignant behaviour in intraductal papillary neoplasm of the bile duct　M. M. Sasaki, T.;Yoneda, N.;Nomoto, K.;Tsuneyama, K.;Sato, Y.;Nakanuma, Y.　Histopathology　62　3　446-57　2013
　Increased expression of mitochondrial proteins associated with autophagy in biliary epithelial lesions in primary biliary cirrhosis　M. M. Sasaki, M.;Sato, Y.;Nakanuma, Y.　Liver Int　33　2　312-20　2013
　S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species　N. O. Takuwa, S.;Takashima, S.;Ohtani, K.;Okamoto, Y.;Tanaka, T.;Hirano, K.;Usui, S.;Wang, F.;Du, W.;Yoshioka, K.;Banno, Y.;Sasaki, M.;Ichi, I.;Okamura, M.;Sugimoto, N.;Mizugishi, K.;Nakanuma, Y.;Ishii, I.;Takamura, M.;Kaneko, S.;Kojo, S.;Satouchi, K.;Mitumori, K.;Chun, J.;Takuwa, Y.　Cardiovasc Res　85　3　484-93　2010
　Epidermal growth factor induces cytokeratin 19 expression accompanied by increased growth abilities in human hepatocellular carcinoma　Yoneda, Norihide;Sato, Yasunori;Kitao, Azusa;Ikeda, Hiroko;Sawada-Kitamura, Seiko;Miyakoshi, Masami;Harada, Kenichi;Sasaki, Motoko;Matsui, Osamu;Nakanuma, Yasuni　LABORATORY INVESTIGATION　91　2　262-272　2011
　Characterization of possible precursors of intraductal papillary neoplasm of the bile duct involving peribiliary glands　Sato, Yasunori;Harada, Kenichi;Sasaki, Motoko;Nakanuma, Yasuni　HEPATOLOGY　56　0　607A-608A　2012
　Characterization of hepatocellular adenoma based on the phenotypic classification: The Kanazawa experience　Sasaki, Motoko; Yoneda, Norihide; Kitamura, Seiko; Sato, Yasunori; Nakanuma, Yasuni　Hepatology Research　41　10　982-988　2011/10/01　
　Biliary infection may exacerbate biliary cystogenesis through the induction of VEGF in cholangiocytes of the polycystic kidney (PCK) rat　Ren, Xiangshan; Sato, Yasunori; Harada, Kenichi; Sasaki, Motoko; Yoneda, Norihide; Lin, Zhenhua; Nakanuma, Yasuni　American Journal of Pathology　179　6　2845-2854　2011/12/01　
　Participation of peribiliary glands in biliary tract pathophysiologies　Igarashi, Saya; Sato, Yasunori; Ren, Xiangshan; Harada, Kenichi; Sasaki, Motoko; Nakanuma, Yasuni　World Journal of Hepatology　5　8　425-432　2013/09/24　
　Immunohistochemical characteristics and malignant progression of hepatic cystic neoplasms in comparison with pancreatic counterparts　Matsubara, Takashi; Sato, Yasunori; Sasaki, Motoko; Harada, Kenichi; Nomoto, Kazuhiro; Tsuneyama, Koichi; Nakamura, Koichi; Gabata, Toshifumi; Matsui, Osamu; Nakanuma, Yasuni　Human Pathology　43　12　2177-2186　2012/12/01　
　Hyperplastic hepatocellular nodule with localized hemangiomatosis: A hither-to unrecognized type of hypervascular hepatic lesion　Sasaki, Motoko; Ikeda, Tatsuru; Hatanaka, Kanako; Nakanuma, Yasuni　Hepatology Research　44　10　E77-E83　2014/01/01　
　Histological characteristics of biliary intraepithelial neoplasia-3 and intraepithelial spread of cholangiocarcinoma　Sato, Yasunori; Harada, Kenichi; Sasaki, Motoko; Nakanuma, Yasuni　Virchows Archiv　462　4　421-427　2013/04/01　
　Serum amyloid A-positive hepatocellular neoplasms in the resected livers from 3 patients with alcoholic cirrhosis　Sasaki, Motoko; Kondo, Fukuo; Sawai, Yoshiyuki; Imai, Yasuharu; Kadowaki, Susumu; Sano, Keiji; Fukusato, Toshio; Matsui, Osamu; Nakanuma, Yasuni　Histology and Histopathology　28　11　1499-1505　2013/11/01　
　α-Fetoprotein-producing gastric carcinoma and combined hepatocellular and cholangiocarcinoma show similar morphology but different histogenesis with respect to SALL4 expression　Ikeda, Hiroko; Sato, Yasunori; Yoneda, Norihide; Harada, Kenichi; Sasaki, Motoko; Kitamura, Seiko; Sudo, Yoshiko; Ooi, Akishi; Nakanuma, Yasuni　Human Pathology　43　11　1955-1963　2012/11/01　
　Clinicopathologic significance of combined hepatocellular- cholangiocarcinoma with stem cell subtype components with reference to the expression of putative stem cell markers　Ikeda, Hiroko; Harada, Kenichi; Sato, Yasunori; Sasaki, Motoko; Yoneda, Norihide; Kitamura, Seiko; Sudo, Yoshiko; Ooi, Akishi; Nakanuma, Yasuni　American Journal of Clinical Pathology　140　3　329-340　2013/09/01　
　Autophagy may occur at an early stage of cholangiocarcinogenesis via biliary intraepithelial neoplasia　Sasaki, Motoko; Nitta, Takeo; Sato, Yasunori; Nakanuma, Yasuni　Human Pathology　46　2　202-209　2015/01/01　
　Hilar cholangiocarcinoma and pancreatic ductal adenocarcinoma share similar histopathologies, immunophenotypes, and development-related molecules　Gandou, Chihiro; Harada, Kenichi; Sato, Yasunori; Igarashi, Saya; Sasaki, Motoko; Ikeda, Hiroko; Nakanuma, Yasuni　Human Pathology　44　5　811-821　2013/05/01　
　Heat shock proteins 27 and 70 are potential biliary markers for the detection of cholangiocarcinoma　Sato, Yasunori; Harada, Kenichi; Sasaki, Motoko; Yasaka, Takahiro; Nakanuma, Yasuni　American Journal of Pathology　180　1　123-130　2012/01/01　
　GNAS and KRAS mutations are common in intraductal papillary neoplasms of the bile duct　Sasaki, Motoko; Matsubara, Takashi; Nitta, Takeo; Sato, Yasunori; Nakanuma, Yasuni　PLoS ONE　8　12　2013/12/02　
　Beta-catenin-activated hepatocellular adenoma showing hyperintensity on hepatobiliary-phase gadoxetic-enhanced magnetic resonance imaging and overexpression of OATP8　Yoneda, Norihide; Matsui, Osamu; Kitao, Azusa; Kozaka, Kazuto; Gabata, Toshifumi; Sasaki, Motoko; Nakanuma, Yasuni; Murata, Kiyoshi; Tani, Toru　Japanese Journal of Radiology　30　9　777-782　2012/11/01　
　Clinicopathological significance of S100 protein expression in cholangiocarcinoma　Sato, Yasunori; Harada, Kenichi; Sasaki, Motoko; Nakanuma, Yasuni　Journal of Gastroenterology and Hepatology (Australia)　28　8　1422-1429　2013/01/01　
　Cystic and micropapillary epithelial changes of peribiliary glands might represent a precursor lesion of biliary epithelial neoplasms　Sato, Yasunori; Harada, Kenichi; Sasaki, Motoko; Nakanuma, Yasuni　Virchows Archiv　464　2　157-163　2014/02/01　
　Different carcinogenic process in cholangiocarcinoma cases epidemically developing among workers of a printing company in Japan　Sato, Yasunori; Kubo, Shoji; Takemura, Shigekazu; Sugawara, Yasuhiko; Tanaka, Shogo; Fujikawa, Masahiro; Arimoto, Akira; Harada, Kenichi; Sasaki, Motoko; Nakanuma, Yasuni　International Journal of Clinical and Experimental Pathology　7　8　4745-4754　2014/01/01　
　Infiltration of inflammatory cells expressing mitochondrial proteins around bile ducts and in biliary epithelial layer may be involved in the pathogenesis in primary biliary cirrhosis　Sasaki, Motoko; Kakuda, Yuko; Miyakoshi, Masami; Sato, Yasunori; Nakanuma, Yasuni　Journal of Clinical Pathology　67　6　470-476　2014/01/01　
　Intrahepatic cholangiocarcinoma arising in chronic advanced liver disease and the cholangiocarcinomatous component of hepatocellular cholangiocarcinoma share common phenotypes and cholangiocarcinogenesis　Xu, Jing; Sasaki, Motoko; Harada, Kenichi; Sato, Yasunori; Ikeda, Hiroko; Kim, Jihun; Yu, Eunsil; Nakanuma, Yasuni　Histopathology　59　6　1090-1099　2011/12/01　
　Intrahepatic cholangiocarcinomas in cirrhosis are hypervascular in comparison with those in normal livers　Xu, Jing; Igarashi, Saya; Sasaki, Motoko; Matsubara, Takashi; Yoneda, Norihide; Kozaka, Kazuto; Ikeda, Hiroko; Kim, Jihun; Yu, Eunsil; Matsui, Osamu; Nakanuma, Yasuni　Liver International　32　7　1156-1164　2012/08/01　
　Metachronous intracystic and intraductal papillary neoplasms of the biliary tree　Sato, Hirohide; Sato, Yasunori; Harada, Kenichi; Sasaki, Motoko; Hirano, Katsuyasu; Nakanuma, Yasuni　World Journal of Gastroenterology　19　36　6125-6126　2013/09/28　
　Chemokine-chemokine receptor CCL2-CCR2 and CX3CL1-CX3CR1 axis may play a role in the aggravated inflammation in primary biliary cirrhosis　Sasaki, Motoko; Miyakoshi, Masami; Sato, Yasunori; Nakanuma, Yasuni　Digestive Diseases and Sciences　59　2　358-364　2014/02/01　
　Bile duct expression of pancreatic and duodenal homeobox 1 in perihilar cholangiocarcinogenesis　Igarashi, Saya; Matsubara, Takashi; Harada, Kenichi; Ikeda, Hiroko; Sato, Yasunori; Sasaki, Motoko; Matsui, Osamu; Nakanuma, Yasuni　Histopathology　61　2　266-276　2012/08/01　
　Proposal of a new disease concept biliary diseases with pancreatic counterparts. Anatomical and pathological bases　Nakanuma, Yasuni; Harada, Kenichi; Sasaki, Motoko; Sato, Yasunori　Histology and Histopathology　29　1　1-10　2014/01/01　
　Pathological diagnosis of flat epithelial lesions of the biliary tract with emphasis on biliary intraepithelial neoplasia　Sato, Yasunori; Sasaki, Motoko; Harada, Kenichi; Aishima, Shinichi; Fukusato, Toshio; Ojima, Hidenori; Kanai, Yae; Kage, Masayoshi; Nakanuma, Yasuni; Tsubouchi, Hirohito　Journal of Gastroenterology　49　1　64-72　2014/01/01　
　A case of mucinous cystic neoplasm of the liver: Description of Sonazoid-enhanced ultrasound imaging and histopathologic findings　Sugimoto, Katsutoshi; Moriyasu, Fuminori; Kono, Shin; Sasaki, Motoko; Nakanuma, Yasuni; Imai, Yasuharu　Journal of Medical Ultrasonics　40　3　243-250　2013/07/01　
　Multiple hypervascular FNH-like lesions in a patient with no history of alcohol abuse or chronic liver disease　Tani, Joji; Miyoshi, Hisaaki; Sasaki, Motoko; Nakanuma, Yasuni; Nomura, Takako; Yoneyama, Hirohito; Morishita, Asahiro; Kobara, Hideki; Hirohito, Mori; Himoto., Takashi; Masaki, Tsutomu　Internal Medicine　52　19　2225-2230　2013/10/08　
　Evaluation of a new histologic staging and grading system for primary biliary cirrhosis in comparison with classical systems　Kakuda, Yuko; Harada, Kenichi; Sawada-Kitamura, Seiko; Ikeda, Hiroko; Sato, Yasunori; Sasaki, Motoko; Okafuji, Hirofumi; Mizukoshi, Eishiro; Terasaki, Shuichi; Ohta, Hajime; Kasashima, Satomi; Kawashima, Atsuhiro; Kaizaki, Yasuharu; Kaneko, Shuichi; Nakanuma, Yasuni　Human Pathology　44　6　1107-1117　2013/06/01　
　A possible involvement of p62/sequestosome-1 in the process of biliary epithelial autophagy and senescence in primary biliary cirrhosis　Sasaki, Motoko; Miyakoshi, Masami; Sato, Yasunori; Nakanuma, Yasuni　Liver International　32　3　487-499　2012/03/01　
　Clinicopathological study of primary biliary cirrhosis with interface hepatitis compared to autoimmune hepatitis　Kobayashi, Mio; Kakuda, Yuko; Harada, Kenichi; Sato, Yasunori; Sasaki, Motoko; Ikeda, Hiroko; Terada, Mitsuhiro; Mukai, Munenori; Kaneko, Shuichi; Nakanuma, Yasuni　World Journal of Gastroenterology　20　13　3597-3608　2014/04/07　
　Activation of the PI3K/mTOR pathway is involved in cystic proliferation of cholangiocytes of the PCK rat　Ren, Xiangshan; Sato, Yasunori; Harada, Kenichi; Sasaki, Motoko; Furubo, Shinichi; Song, Jingyu; Nakanuma, Yasuni　PLoS ONE　9　1　2014/01/30　
　Participation of bile ductular cells in the pathological progression of non-alcoholic fatty liver disease　Chiba, Mayumi; Sasaki, Motoko; Kitamura, Seiko; Ikeda, Hiroko; Sato, Yasunori; Nakanuma, Yasuni　Journal of Clinical Pathology　64　7　564-570　2011/07/01　
　Biliary adenofibroma with ominous features of imminent malignant changes　Tsutsui, Akemi; Bando, Yoshimi; Sato, Yasunori; Miyake, Hidenori; Sawada-Kitamura, Seiko; Shibata, Hiroshi; Kakuda, Yuko; Harada, Kenichi; Sasaki, Motoko; Nakanuma, Yasuni　Clinical Journal of Gastroenterology　7　5　441-448　2014/01/01　
　Autophagy may promote carcinoma cell invasion and correlate with poor prognosis in cholangiocarcinoma　Nitta, Takeo; Sato, Yasunori; Ren, Xiangshan; Harada, Kenichi; Sasaki, Motoko; Hirano, Satoshi; Nakanuma, Yasuni　International Journal of Clinical and Experimental Pathology　7　8　4913-4921　2014/01/01　
　Induction of elastin expression in vascular endothelial cells relates to hepatoportal sclerosis in idiopathic portal hypertension: Possible link to serum anti-endothelial cell antibodies　Sato, Yasunori; Ren, Xiangshan; Harada, Kenichi; Sasaki, Motoko; Morikawa, Hiroyasu; Shiomi, Susumu; Honda, Masao; Kaneko, Shuichi; Nakanuma, Yasuni　Clinical and Experimental Immunology　167　3　532-542　2012/03/01

Conference Presentations

Impaired biliary bicarbonate umbrella may play a central role in deregulated autophagy and cellular senescence in cholangiocytes in primary biliary cholangitis(conference：AASLD The Liver Meeting 2017 )(2017/11/11)
Bile acids and cholangiocyte autophagy(conference：The XXIV International Bile Acid Meeting“Bile Acids in Health and Disease”. Düsseldorf)(2016)
Enhanced VASH1 expression in splenic sinus lining cells relates to splenomegaly in IPH(conference：The Asian Pacific Association for the Study of the Liver (APASL) 2016 Tokyo)(2016)
Mutations of p53, ARID 1A and KRAS mutations and their association with “subtypes with stem-cell feature” in combined hepatocellular-cholangiocellular carcinoma. (conference：The 66th Annual meeting of American Association for the Study of Liver Diseases (AASLD). San Francisco)(2015)
Increased expression of ORM1-like protein 3 (ORMDL3) in biliary epithelial cells may be related to the pathogenesis of primary biliary cirrhosis.(conference：The 66th Annual meeting of American Association for the Study of Liver Diseases (AASLD). San Francisco)(2015)

show all

ARID 1A mutations may represent a novel pathway of carcinogenesis in biliary carcinomas.(conference：The 66th Annual meeting of American Association for the Study of Liver Diseases (AASLD). San Francisco)(2015)
Correlation of destruction of canals of Hering with the progression of the primary biliary cirrhosis stage(conference：The 64th Annual meeting of American Association for the Study of Liver Diseases (AASLD). Washington, DC)(2013)
Histological characterization of biliary intraepithelial neoplasia with respect to pancreatic intraepithelial neoplasia(conference：The 64th Annual meeting of American Association for the Study of Liver Diseases (AASLD). Washington, DC)(2013)
Autophagy may be an early event in the stepwise carcinogenesis via biliary intraepithelial neoplasia in cholangiocarcinoma associated with hepatolithiasis. (conference：The 65th Annual meeting of American Association for the Study of Liver Diseases (AASLD).Boston)(2014)
A possible involvement of endoplasmic reticulum stress in the process of biliary epithelial autophagy and endoplasmic reticulum stress in the process of biliary epithelial autophagy and senescence in primary biliary cirrhosis. (conference：The 65th Annual meeting of American Association for the Study of Liver Diseases (AASLD).Boston)(2014)
Pathology of hepatolithiasis with an emphasis on metaplasia of biliary mucosa. (conference：First Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association (A-PHPBA))(2007)
Short Course: Chronic Cholangitis and Cholangiocarcinoma: Hepatolithiasis and cholangiocarcinoma: phenotypic and changes.(conference：XXIIth International Congress of the International Academy of Pathology　and 14th World Congress of Academic and Enviromental Pathology. Nagoya)(2000)
Prevalence and significance of ´Subtypes with stem-cell feature´ in combined hepatocellular- cholangiocarcinoma and hepatocellular carcinoma. (conference：The 102nd Annual meeting of United States and Canadian Academy of Pathology (USCAP))(2013)
Infiltration of inflammatory cells expressing mitochondrial proteins around bile ducts and intraepithelial layer may be involved to the pathogenesis in primary biliary cirrhosis. (conference：The 102nd Annual meeting of United States and Canadian Academy of Pathology (USCAP) Baltimore,2013)(2013)
Clinicopathological Characteristics of serum amyloid a-positive hepatocellular neoplasms arising in advanced alcoholic liver disease(conference：The 102nd Annual meeting of United States and Canadian Academy of Pathology (USCAP))(2013)
Intraepithelial infiltration of ORM1-like protein 3 (ORMDL3) –expressing cells may be closely related to the pathogenesis of primary biliary cirrhosis.(conference：he 63th Annual Meeting of American Association for the Study of Liver Diseases (AASLD)(2012)
Chemokines CCL2 and CX3CL1 as senescence-associated secretory phenotypes may play a role in aggravated inflammation in primary biliary cirrhosis(conference：The 63th Annual Meeting of American Association for the Study of Liver Diseases(AASLD))(2012)
Serum amyloid A-positive hepatocellular neoplasms may be a hitherto-unrecognized type of inflammatory hepatocellular tumor arising in advanced alcoholic liver disease(conference：The 63th Annual Meeting of American Association for the Study of Liver Diseases (AASLD))(2012)
The deregulated autophagy of mitochondria may be involved in the pathogenesis in primary biliary cirrhosis. (conference：The 101st Annual meeting of United States and Canadian Academy of Pathology (USCAP))(2012)
The overexpression of enhancer of zeste homolog 2 (EZH2) may be related to malignant behaviors in intraductal papillary neoplasm of the bile duct(conference：The 101st Annual meeting of United States and Canadian Academy of Pathology (USCAP))(2012)
Increased expression of mitochondrial proteins associated with autophagy in the biliary epithelial lesions in primary biliary cirrhosis.(conference：The 62th Annual Meeting of American Association for the Study of Liver Diseases (AASLD))(2011)
Inflammatory hepatocellular adenomas arise in alcoholic cirrhosis.(conference：The 2nd Asia-Pacific Primary Liver Cancer Expert Meeting)(2011)
ATM/p53/p21 pathway is involved in the oxidative stress-induced cellular senescence in biliary epithelial cell in primary biliary cirrhosis(conference：The 57th Annual Meeting of American Association for the Study of Liver Diseases (AASLD))(2006)
Cellular senescence of bile ductular cells may be involved in the　pathophysiology in ductular rections in chronic liver diseases.(conference：The 59th Annual Meeting of American Association for the Study of Liver Diseases (AASLD).)(2008)
Cellular senescence of biliary epithelial cells characterizes the damaged small bile ducts in primary biliary cirrhosis. (conference：The 59th Annual Meeting of American Association for the Study of Liver Diseases (AASLD).)(2008)
A case of intraductal/intracystic papillary neoplasm of the bile duct (IPN-B).(2008)
modulation of microenvironment by senescent biliary epithelial cells in the pathogenesis of bile duct lesions in primary biliary cirrhosis.(conference：The 60th Annual Meeting of American Association for the Study of Liver Diseases(AASLD))(2009)
A possible involvement of autophagy in the process of biliary epithelial senescence in primary biliary cirrhosis.(conference：The 60th Annual Meeting of American Association for the Study of Liver Diseases (AASLD))(2009)
A Possible involvement of P62/sequestosome-1 in the process of biliary epithelial autophagy and senescence in primary biliary cirrhosis. (conference：The 61th Annual Meeting of American Association for the Study of Liver Diseases (AASLD))(2010)
Autophagy may precede cellular senescence of bile ductular cells in ductuar reaction in 　primary biliary cirrhosis. (conference： The 61th Annual Meeting of American Association for the Study of Liver Diseases(AASLD))(2010)
Augmented and irregularly distributed expression of trefoil factor family-1,2,3 and their putative receptor in small bile ducts in primary biliary cirrhosis. (conference：The 53th Annual meeting of American Association for the Study of Liver Diseases (AASLD))(2002)
Decreased expression of bmi1 is closely associated with cellular senescence in damaged small bile ducts in primary biliary cirrhosis.(conference：The 56th Annual Meeting of American Association for the Study of Liver Diseases (AASLD))(2005)
Hepatocytes growth factor activator type 1 (HAI-1) is augmented in intrahepatic small bile ducts in primary biliary cirrhosis(conference：The 56th Annual Meeting of American Association for the Study of Liver Diseases (AASLD))(2005)
GNAS and KRAS mutations are common in intraductal papillary neoplasm of the bile duct. (conference：The 64th Annual Meeting of American Association for the Study of Liver Diseases (AASLD))(2013)
Serum amyloid A (SAA)-positive hepatocellular neoplasms and SAA-negative focal nodular hyperplasia-like nodules arising in alcoholic cirrhosis.(conference：The 64th Annual Meeting of American Association for the Study of Liver Diseases (AASLD))(2013)
Infiltration of macrophages and plasma cells with coarse granular expression of mitochondrial proteins around bile ducts and intraepithelial layer may be involved in the pathogenesis of bile duct lesions in primary biliary cirrhosis. (conference：The 64th Annual Meeting of American Association for the Study of Liver Diseases (AASLD))(2013)
Analysis of 3D human intrahepatic biliary structures in liver diseases using tissue clearing method(2024/03/28)
Re-classification of combined hepatocellular-cholangiocarcinoma and small duct type intrahepatic cholangiocarcinoma by genetic alterations. (conference：The Liver Meeting® 2024)(2024/11/18)
Significance of heterogeneous biliary epithelial senescence as a possible target of new therapies in primary biliary cholangitis.(conference：The Liver Meeting® 2024)(2024/11/18)
Expression and clinicopathological significance of fibroblast growth factor receptor 2 (FGFR2) in combined hepatocellular-cholangiocarcinoma.(conference：The Liver Meeting® 2023)(2023/11/09)
A heterogeneous subtype of biliary epithelial senescence may be involved in the pathogenesis of primary biliary cholangitis.(conference：The Liver Meeting® 2023)(2023/11/09)
Expression of FGFR2 in combined hepatocellular-cholangiocarcinoma and intrahepatic cholangiocarcinoma: Clinicopathological study(2023/07/27)
An involvement of hippo-yes-associated protein (yap) pathway and its association with biliary epithelial senescence in the pathogenesis of primary biliary cholangitis(conference：The Liver Meeting® 2022 )(2022/11/07)
AASLD/JSH Symposium: Women's Health. Liver Masses in Women: Adenomas & HCC. (conference：The Liver Meeting® 2022 )(2022/11/07)
Increased expression of interferon- induced protein with tetratricopeptide repeats 3 (Ifit3) in senescent biliary epithelial cells may play a role in the pathogenesis of primary biliary cholangitis(conference：AASLD The Liver Meeting Digital Experience™ 2020.)(2020/11/13)
Biliary epithelial senescence may play a critical role in the pathogenesis and could be a target of senolytic therapy in primary biliary cholangitis(conference：AASLD The Liver Meeting 2018 )(2018/11/09)
Anemia associated with dextran deposits in bone marrow tissues of patients undergoing hemodialysis(2018/10/12)
Altered expression of various inflammation and immune-related genes in senescent biliary epithelial cells relating to primary biliary cholangitis(conference：Asian Pacific Association for the Study of the Liver Single Topic Conference)(2019/04/18)
ARID1A alterations may be related to “ductal plate malformation” pattern in cholangiolocellular carcinoma and combined hepatocellular carcinoma-cholangiocarcinoma(conference：AASLD The Liver Meeting 2018 )(2018/11/09)
Increased p16INK4a-expressing senescent biliary epithelial cells in ductular reactions is associated with inadequate response to ursodeoxycholic acid and could be a target of senolytic elimination in primary biliary cholangitis(conference：AASLD The Liver Meeting 2019)(2019/11/08)

Others

　Expression of trefoil factor family 1, 2, and 3 peptide is augmented in hepatolithiasis.　25　5　763-770　2004/05

Arts and Fieldwork

Patent

Theme to the desired joint research

○Cellular senescence and dysregulated autophagy in hepatobiliary diseases
○Pathology and Pathogenesis of hepatobiliary disease

Grant-in-Aid for Scientific Research

○「老化細胞制御による肝臓病の新しい治療法の開発」(2018-2020)　
○「自己免疫性疾患におけるオートファジー異常の役割の解明」(2015-2017)　
○「オートファジー異常に着目した原発性胆汁性肝硬変の新たな解析」(2012-2014)
○「細胞老化に着目した肝臓病の新たな解析」(2009-2011)　
○「原発性胆汁性肝硬変における胆管消失発生の分子機構：胆管細胞老化の関与を中心に」(2006-)
○「肝内胆管消失症候群における粘膜上皮再生・修復の分子機構」(2003-)　
○「増生細胆管でのアポムチンサブタイプの発現とその意義：増生細胆管は肝ステムセルか？」(1997-)　
○「肝内胆管系におけるムチンコア蛋白の正常分布と疾患に伴う変動；肝内結石症を中心に」(1996-)　
○「ウイルス性肝硬変の再生結節内の”ルイスY抗原陰性巣”；新しい癌関連病巣か」(1995-)　
○「肝内結石症に合併する肝内胆管癌の発生，進展に関する免疫組織化学的検討」(1993-)　
○「胆汁中粘液糖蛋白の解析：肝内胆管病変との対比を中心に」(1994-)　
○「老化細胞を標的とした原発性胆汁性胆管炎の新しい治療法開発」(2022-2024)　

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Human Pathology 1(2023)
○Human Pathology 2(2023)
○Human Pathology 1(2023)
○Human Pathology 2(2023)
○Human Pathology 2(2023)
○Human Pathology 2(2023)
○Human Pathology 2(2023)
○Human Pathology 2(2023)
○Human Pathology 2(2023)
○Human Pathology 2(2023)
○Human Pathology 1(2022)
○Human Pathology 1(2022)
○Human Pathology 2(2022)
○Human Pathology 2(2022)
○Human Pathology 2(2022)
○Human Pathology 2(2022)
○Human Pathology 2(2022)
○Human Pathology 2(2022)
○Human Pathology 2(2022)
○Human Pathology 2(2021)
○Human Pathology 2(2020)
○Human Pathology2(2019)
○Human Pathology2(2018)
○Human Pathology(2017)
○Human Pathology(2017)

Classes (Graduate Schools)

○Morpho-Functional Pathology(2023)
○Morpho-Functional Pathology(2023)
○Morpho-Functional Pathology(2023)
○Morpho-Functional Pathology(2023)
○Morpho-Functional Pathology(2023)
○Morpho-Functional Pathology(2023)
○Morpho-Functional Pathology(2023)
○Morpho-Functional Pathology(2023)
○Morpho-Functional Pathology(2023)
○Morpho-Functional Pathology(2023)
○Morpho-Functional Pathology(2023)
○Morpho-Functional Pathology(2023)
○Morpho-Functional Pathology(2023)
○Morpho-Functional Pathology(2023)
○Morpho-Functional Pathology(2023)
○Morpho-Functional Pathology(2023)
○Morpho-Functional Pathology(2022)
○Morpho-Functional Pathology(2022)
○Morpho-Functional Pathology(2022)
○Morpho-Functional Pathology(2022)
○Morpho-Functional Pathology(2022)
○Morpho-Functional Pathology(2022)
○Morpho-Functional Pathology(2022)
○Morpho-Functional Pathology(2022)
○Morpho-Functional Pathology(2022)
○Morpho-Functional Pathology(2022)
○Morpho-Functional Pathology(2022)
○Morpho-Functional Pathology(2022)
○Morpho-Functional Pathology(2022)
○Morpho-Functional Pathology(2022)
○Morpho-Functional Pathology(2022)
○Morpho-Functional Pathology(2022)
○Morpho-Functional Pathology(2021)
○Morpho-Functional Pathology(2021)
○Morpho-Functional Pathology(2020)
○Morpho-Functional Pathology(2020)
○Morpho-Functional Pathology(2019)
○Morpho-Functional Pathology(2019)
○The Human Body in Health and Disease Curriculum 4(2018)

International Project

International Students

Lecture themes

Others (Social Activities)

○日本肝胆膵外科学会(20110401-20210331)

Associate Professor SASAKI Motoko

Faculty, Affiliation

College and School Educational Field

Laboratory

Academic Background

Career

Year & Month of Birth

Academic Society

Award

Specialities

Speciality Keywords

Research Themes

Pathogenesis of Primary biliary cholangitis.

Immunohistochemical investigation of outbreak and development of intrahepatic bile duct cancer coexisting with intrahepatic lithiasis

Involvement of cellular senescence and autophagy in hepatobiliary diseases

Mucin core proteins in Hepatobiliary disease

Books

Papers

Conference Presentations

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

Classes (Graduate Schools)

International Project

International Students

Lecture themes

Others (Social Activities)

Associate Professor　SASAKI Motoko