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last modified：2025/04/03
Assistant Professor KINOSHITA Takeshi
Faculty, Affiliation
Cancer Research Institute
College and School Educational Field
Division of Medicine, Graduate School of Medical Science
Laboratory
Division of Immunology and Molecular Biology TEL:076-265-2732 FAX:076-234-4525
Academic Background
【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor Graduate School, Division of Medicine 199803 Completed
【Academic background(Bachelor's Degree)】
University of Tsukuba 198703
Career
Kanazawa University(1998/10/01-)
Year & Month of Birth
1964/04
Academic Society
Award
Specialities
Cell biology、Molecular biology
Speciality Keywords
innate-immunity,inflammation,apoptosis
Research Themes
Multiple roles for innate immunity
Books
Papers
- Mechanism and repertoire of ASC-mediated gene expression M Hasegawa,R Imamura,Kou Motani,T Nishiuchi,N Matsumoto,T Kinoshita,T Suda The Journal of Immunology Vol.182 No.12 7655 2009/06/15
- PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1 beta secretion T Kinoshita,YT Wang,M Hasegawa,R Imamura,T Suda JOURNAL OF BIOLOGICAL CHEMISTRY 280 23 21720 2005/06
- PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1 YT Wang,M Hasegawa,R Imamura,T Kinoshita,C Kondo,K Konaka,T Suda INTERNATIONAL IMMUNOLOGY 16 6 777 2004/06
- MT-MMPs and their functions: Activation of a recombinant membrane-type matrix metalloproteinase 1 (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases-2 (TIMP-2) H Sato,T Kinoshita,T Takino,K Nakayama,M Seiki TISSUE INHIBITORS OF METALLOPROTEINASES IN DEVELOPMENT AND DISEASE, PROCEEDINGS 97 2000
- Fas-associated factor 1 is a negative regulator of PYRIN-containing Apaf-1-like protein 1 Takeshi Kinoshita,Chiaki Kondoh,Mizuho Hasegawa,Ryu Imamura,Takashi Suda INTERNATIONAL IMMUNOLOGY 18 12 1701 2006/12
- NLRP3 Mediates NF-kappa B Activation and Cytokine Induction in Microbially Induced and Sterile Inflammation Takeshi Kinoshita,Ryu Imamura,Hiroko Kushiyama,Takashi Suda PLOS ONE 10 3 e0119179 2015/03
- ASC-mediated NF-kappa B activation leading to interleukin-8 production requires caspase-8 and is inhibited by CLARP M Hasegawa,R Imamura,T Kinoshita,N Matsumoto,J Masumoto,N Inohara,T Suda JOURNAL OF BIOLOGICAL CHEMISTRY 280 15 15122 2005/04
- Expression of NLRP7 (PYPAF3, NALP7) protein in endometrial cancer tissues Satoshi Ohno,Takeshi Kinoshita,Yumiko Ohno,Toshinari Minamoto,Nobutaka Suzuki,Masaki Inoue,Takashi Suda ANTICANCER RESEARCH 28 4C 2493 2008/07
- Caspase-1 protein induces apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)-mediated necrosis independently of its catalytic activity. Motani K,Kushiyama H,Imamura R,Kinoshita T,Nishiuchi T,Suda T The Journal of biological chemistry 286 39 33963 2011/09
- Activation of ASC induces apoptosis or necrosis depending on the cell type and causes tumor eradication MOTANI Kou,KAWASE Kouji,IMAMURA Ryu,KINOSHITA Takeshi,KUSHIYAMA Hiroko,SUDA Takashi Cancer Science 101 8 1822 2010
- Mechanism and Repertoire of ASC-Mediated Gene Expression Mizuho Hasegawa,Ryu Imamura,Kou Motani,Takumi Nishiuchi,Norihiko Matsumoto,Takeshi Kinoshita,Takashi Suda JOURNAL OF IMMUNOLOGY 182 12 7655 2009/06
- Mechanism of ASC-mediated apoptosis: Bid-dependent apoptosis in type II cells M. Hasegawa,K. Kawase,N. Inohara,R. Imamura,W. -C Yeh,T. Kinoshita,T. Suda ONCOGENE 26 12 1748 2007/03
- Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein-1 is a new member of the Cupin superfamily - A possible multifunctional protein acting as an invasion suppressor down-regulated in tumors T Uekita,Gotoh, I,T Kinoshita,Y Itoh,H Sato,T Shiomi,Y Okada,M Seiki JOURNAL OF BIOLOGICAL CHEMISTRY 279 13 12734 2004/03
- Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2. Sato H,Kinoshita T,Takino T,Nakayama K,Seiki M FEBS Letters 393 1 101 1996/09
- Processing of a precursor of 72-kilodalton type IV collagenase/gelatinase A by a recombinant membrane-type 1 matrix metalloproteinase. Kinoshita T,Sato H,Takino T,Itoh M,Akizawa T,Seiki M Cancer Research 56 11 2535 1996/06
- Cell surface binding and activation of gelatinase A induced by expression of membrane-type-1-matrix metalloproteinase (MT1-MMP). Sato H,Takino T,Kinoshita T,Imai K,Okada Y,Stetler Stevenson WG,Seiki M FEBS Letters 385 3 238 1996/05
- Anti-Inflammatory Activity of PYNOD and Its Mechanism in Humans and Mice Ryu Imamura,Yetao Wang,Takeshi Kinoshita,Misao Suzuki,Tetsuo Noda,Junji Sagara,Shun'ichiro Taniguchi,Hiroshi Okamoto,Takashi Suda JOURNAL OF IMMUNOLOGY 184 10 5874 2010/05
- Caspase-1 induces apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC)-mediated necrosis independently of its catalytic activity Kou Motani,H Kushiyama,R Imamura,T Kinoshita,T Nishiuchi,T Suda The Journal of Biological Chemistry Vol.286 33963 2011/08/08
- Fas ligand induces cell-autonomous NF-kappa B activation and interleukin-8 production by a mechanism distinct from that of tumor necrosis factor-alpha R Imamura,K Konaka,N Matsumoto,M Hasegawa,M Fukui,N Mukaida,T Kinoshita,T Suda JOURNAL OF BIOLOGICAL CHEMISTRY 279 45 46415 2004/11
- Mechanism of ASC-mediated apoptosis: Bid-dependent apoptosis in type II cells M. Hasegawa,K. Kawase,N. Inohara,R. Imamura,W. -C Yeh,T. Kinoshita,T. Suda ONCOGENE 26 12 1748 2007/03
- Vitamin B6 Prevents IL-1 beta Protein Production by Inhibiting NLRP3 Inflammasome Activation Peipei Zhang,Kohsuke Tsuchiya,Takeshi Kinoshita,Hiroko Kushiyama,Sofya Suidasari,Mizuki Hatakeyama,Hisanori Imura,Norihisa Kato,Takashi Suda JOURNAL OF BIOLOGICAL CHEMISTRY 291 47 24517 2016/11
- Caspase-1 initiates apoptosis in the absence of gasdermin D. Tsuchiya K,Nakajima S,Hosojima S,Thi Nguyen D,Hattori T,Manh Le T,Hori O,Mahib MR,Yamaguchi Y,Miura M,Kinoshita T,Kushiyama H,Sakurai M,Shiroishi T,Suda T Nature communications 10 1 2091 2019/05
- Caspase‐7 mediates caspase‐1‐induced apoptosis independently of Bid Mamunur Rashid Mahib,Shoko Hosojima,Hiroko Kushiyama,Takeshi Kinoshita,Toshihiko Shiroishi,Takashi Suda,Kohsuke Tsuchiya Microbiology and Immunology 64 2 143 2020/02
- Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes Kohsuke Tsuchiya,Shoko Hosojima,Hideki Hara,Hiroko Kushiyama,Mamunur Rashid Mahib,Takeshi Kinoshita,Takashi Suda Cell Reports 34 12 2021/03/23
- TIMP-2 promotes activation of progelatinase a by membrane-type 1 matrix metalloproteinase immobilized on agarose beads T Kinoshita,H Sato,Akiko,Okada,E Ohuchi,K Imai,Y Okada,M Seiki JOURNAL OF BIOLOGICAL CHEMISTRY 273 26 16098 1998/06
Conference Presentations
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「アポトーシス促進因子Ｂidの制御機構」(2001-)
○「新規Bid結合因子によるアポトーシス制御機構の解明」(2003-)
○「新規BH3ファミリー結合因子の機能解析」(2003-)
○「TNFレセプターファミリーDR6のシグナル伝達機構解明」(2002-)
○「抗炎症因子NLRP7の発現制御と新機能：細胞増殖、分化、運動、腫瘍化への関与」(2008-)
○「自然免疫制御因子PYPAF2, PYPAF3の細胞生存、増殖への関与」(2007-)
○「Fas-associated factor 1はマクロファージ抗炎症因子か？」(2006-)
○「単球系細胞における炎症反応のフィードバック制御機構」(2005-)
○「BH3ファミリーの細胞内局在を制御する新規因子」(2005-)
○「NF-kB活性化を介した自然免疫制御因子群NLRファミリーの新機能」(2009-)
○「自然免疫制御因子NLRPファミリーを介したがん細胞サイトカイン産生制御機構の解明」(2010-)
○「自然免疫ストレスセンサーNLRP3の新機能とその分子機構解明」(2011-2013)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
Classes (Graduate Schools)
○Body Defense Mechanisms(2017)
○Body Defense Mechanisms(2017)
○Body Defense Mechanisms(2016)
○Seminar on Tumor Biology(2016)
○Body Defense Mechanisms(2016)