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Researcher Information

last modified:2019/02/15

Professor NAKADA Mitsutoshi

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Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field

Division of Neuroscience, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Neurosurgery TEL:076-265-2384 FAX:076-234-4262

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor 199903 Completed
【Academic background(Bachelor's Degree)】
Kanazawa University 199403

Career

Kanazawa University(2001/04/01-)

Year & Month of Birth

Academic Society


The Japanese Congress of Neurological Surgeons

JCA

The Japan Society of Molecular Neurosurgery
American Association for Cancer Research











Award

○Hokkoku Foundation for Cancer Research(2001/10/11)
○AACR Scholar-in-Training Award for the 93rd Annual Meeting(2002/04/09)
○Prize for Encouragement from Japan Neurosurgical Society(2002/10/02)
○The American Brain Tumor Association The Basic Research Fellowship Award(2002/10/06)
○Naito Foundation for young scientist(2002/10/06)
○Toyama Award(2003/05/09)
○“JSPS Fellowship Award” for Research Abroad(2005/04/01)
○Hoshino award(2005/10/31)
○AANS poster award(2006/04/26)
○Foundation for Promotion of Cancer Research(2007)
○Japan Brain Foundation(2008)
○Japan Research Foundation for Clinical Pharmacology(2008/12/10)
○The Yasuda Medical Foundation(2008/12/13)
○Foundation for Promotion of Cancer Research(2009/03/30)
○Juzen Medical Award(2010/10/08)
○Osaka Cancer Foundation(2010/12/01)
○Kobayashi Foundation for Cancer Research(2011/06/25)
○Research Award from Japan Research Foundation for Clinical Pharmacology(2011/11/14)
○Public Trust Surgery Research Fund(2012/08/10)
○Takeda Science Foundation(2012/11/12)
○Foundation for Promotion of Cancer Research(2013/01/23)
○The Hokuriku Industrial Advancement Center(2013/08/06)
○Mochida Memorial Foundation for Medical and Pharmaceutical Research(2013/10/25)
○Kanazawa Medical Association(2013/11/10)
○Princess Takamatsu Cancer Research Fund(2015/02/02)
○The Mitani Foundation for Research and Development(2015/07/02)
○Kobayashi International Scholarship Foundation(2017/02/23)
○Kobayashi International Scholarship Foundation(2018/02/21)

Specialities

Neurosurgery

Speciality Keywords

glioblastoma, brain function, glioma stem cell, invasion, molecular target, biomarker

Research Themes

TaylorMade molecular targeted therapy against malignant brain tumor

TaylorMade molecular targeted therapy against malignant brain tumor Glioblastoma, which is one of the most intractable tumors in human malignancies, is characterized by the remarkable proliferative activity and the invasive growth to the surrounding normal brain tissue. We recently revealed that inhibition of GSK3β induces apoptosis and suppresses glioma growth. Based on the data from our basic research, we have started the clinical trial entitled “Phase I/II study using GSK3β inhibitor against recurrent glioblastoma”. We are eager to engage in the translational research using our result of basic research.

The analysis of glioma stem cell biology

The analysis of glioma stem cell biology A characteristic of malignant glioma is their ability to infiltrate and invade the surrounding normal brain tissue. We have identified several molecules which are involved in glioma invasion, such as matrix degrading enzymes (MMP, ADAM and uPA), tyrosine kinases (Eph/ephrin), and intracellular signaling proteins (Rac/Rho). Recently, glioma stem cell has been identified and speculated as the cells which cause the recurrence. We have started to analyze the mechanism of glioma stem cell invasion.

The exploration of biomarker for malignant glioma

The exploration of biomarker for malignant glioma The useful biomarkers are needed for the malignant glioma because the early detection of the malignant glioma has a possibility to cure this miserable disease. We focus sphingosine-1-phosphate (S1P) which is a bioactive lipid that signals through a family of G protein-coupled receptors consisting of 5 members termed S1P1–5. S1P regulates cellular proliferation, migration, and survival. We recently reported that downregulation of S1P1 expression increases proliferative activity, and thus, enhances the malignancy of glioblastomas, resulting in a poor survival. Our results suggest S1P1 might be a useful biomarker for the malignant glioma.

Neuroscience based on awake surgery

Books

  •  Nakada M, Kita D, Furuta T, Watanabe T, Hayashi Y, Hamada JI. Signaling cascades driving the malignant phenotype of glioma cells 2014/10
  •  Receptor tyrosine kinases: principles and functions in glioma invasion 2013/01
  •  Current applications of 5-ALA in glioma diagnostics and therapy 2013/01
  •  Nakada M, Kita D, Hayashi Y, Hamada JI, Kawakami K, Minamoto T RNAi in malignant brain tumors: relevance to molecular and translational research Springer-Verlag Heidelberg in press 2010/01

Papers

  •  Cerebral infarction related to carmustine wafers in glioblastoma Neurol Med Chir (Tokyo) 2 1 36-39 2015/01
  •  Neurolymphomatosis exhibiting repeated exacerbation and remission in both the peripheral and central nervous systems J Neurol Sci in press 2014/07
  •  Functional recovery from pure dyslexia with preservation of subcortical association fiber networks Interdisciplinary Neurosurgery 1 3 59-62 2014/09
  •  Epithelioid glioblastoma arising from pleomorphic xanthoastrocytoma with the BRAF V600E mutation Brain Tumor Pathol 31 172-176 2014/08
  •  The mechanism of chemoresistance against tyrosine kinase inhibitors in malignant glioma Brain Tumor Pathol 31 198-207 2014/08

show all

  •  Membrane-type 1 matrix metalloproteinase regulates fibronectin assembly and N-cahderin adhesion Biochem Biophys Res Commun 2014/06
  •  Identification of the inflow zone of unruptured cerebral aneurysms: comparison of four-dimensional flow MRI- and three-dimensional TOF MRA data AJNR Am J Neuroradiol, 2014/05
  •  Prognostic paradox: Brain damage around the glioblastoma resection cavity J Neurooncol 118 187-192 2014/05
  •  Predictive value of fractional anisotropy of the arcuate fasciculus for the functional recovery of language after brain tumor resection: A preliminary study Clin Neurol Neurosurg 117 45-50 2013/12
  •  Force-detecting gripper and force feedback system for neurosurgery applications Yoneyama T, Watanabe T, Kagawa H, Hamada JI, Hayashi Y, Nakada M Int J Comp Assist Radiol and Surg 2013/01
  •  Reversible acute bilateral blindness resulting from a frontal brain tumor: A case report Br J Neurosurg 1-3 2014/05
  •  PCDH10 is required for the tumorigenicity of glioblastoma cells Biochem Biophys Res Commun 444 13-18 2014/01
  •  Characterizing invading glioma cells based on IDH1-R132H and Ki-67 immunofluorescence Brain Tumor Pathol 2014/01
  •  Ligand-dependent EphB1 signaling suppresses glioma invasion and correlates with patient survival Teng L, Nakada M, Furuyama N, Sabit H, Furuta T, Hayashi Y, Takino T, Dong Y, Sato H, Sai Y, Miyamoto KI, Berens ME, Zhao SG, Hamada JI Neuro-Oncology 15 1710-1720 2013/08
  •  Glycogen synthase kinase 3β inhibition sensitizes human glioblastoma cells to temozolomide by affecting O6-methylguanine DNA methyltransferase promoter methylation via c-Myc signaling Pyko IV, Nakada M, Sabit H, Teng L, Furuyama N, Hayashi Y, Kawakami K, Minamoto T, Fedulau AS, Hamada JI Carcinogenesis 34 2206-2217 2013/09
  •  Progressive adult primary glioblastoma in the medulla oblongata with an unmethylated MGMT promoter and without an IDH mutation Yoshikawa A, Nakada M, Watanabe T, Hayashi Y, Sabit H, Kato Y, Suzuki S, Ooi A, Sato H, Hamada JI Brain Tumor Pathol 30 175-179 2013/07
  •  Surgical strategies for nonenhancing slow-growing gliomas with special reference to functional reorganization: a review with own experience Hayashi Y, Nakada M, Kinoshita M, Hamada JI Neurol Med Chir (Tokyo) 53 438-446 2013/07
  •  Integrin α3 is overexpressed in glioma stem-like cells and promotes invasion Nakada M, Nambu E, Furuyama N, Yoshida Y, Takino T, Hayashi Y, Sato H, Sai Y, Tsuji T, Miyamoto KI, Hirao A, Hamada JI Br J Cancer 108 2516-2524 2013/06
  •  Right superior longitudinal fasciculus: Implications for visuospatial neglect mimicking Gerstmann’s syndrome Hayashi Y, Kinoshita M, Furuta T, Watanabe T, Nakada M, Hamada JI Clinical Neurology and Neurosurgery 115 775-777 2013/06
  •  What bone-part is important to remove in accessing the suprachiasmatic region with less frontal lobe retraction in frontotemporal craniotomies Kinoshita M, Tanaka S, Nakada M, Ozaki N, Hamada JI, Hayashi Y World Neurosurgery 77 342-348 2012/02
  •  Molecular analysis of a recurrent glioblastoma treated with bevacizumab Furuta T, Nakada M, Misaki K, Sato Y, Hayashi Y, Nakanuma Y, Hamada JI Brain Tumor Pathology 2013/03
  •  Recurrent anaplastic meningioma treated by sunitinib based on the absolute quantitative proteomics Yoshikawa A, Nakada M, Ohtsuki S, Hayashi Y, Obuchi W, Sato Y, Ikeda C, Watanabe T, Kawahara Y, Hasegawa T, Sabit H, Kita D, Hayashi Y, Nakanuma Y, Terasaki T, Hamada JI Neuropathology and Applied Neurobiology 38 105-110 2012/02
  •  Progressive tentorial cavernous malformation Furuta T, Nakada M, Watanabe T, Hayashi Y, Hamada JI Surgical Neurology International 3 18 2012/02
  •  Role of Eph/ephrin tyrosine kinase in malignant glioma Nakada M, Hayashi Y, Hamada JI Neuro-Oncology 13 1163-1170 2011/11
  •  MGMT promoter methylation and temozolomide response in choroid plexus carcinoma Misaki K, Nakada M, Mohri M, Hayashi Y, Hamada JI Brain Tumor Pathol 28 259-63 2011/07
  •  Neuro-Sweet disease mimicking recurrent anaplastic astrocytoma associated with therapy-related myelodysplastic syndrome: a case report Shimizu Y, Watanabe T, Nakada M, Hayashi Y, Hamaguchi Y, Sugimori N, Hamada JI Clinical Neurology and Neurosurgery 114 1049-51 2012/09
  •  The strategy for enhancing temozolomide against malignant glioma Nakada M, Furuta T, Hayashi Y, Minamoto T, Hamada JI Frontiers in Radiation Oncology 2 98 2012/08
  •  Anaplastic meningioma with extremely rapid recurrence Kawahara Y, Nakada M, Hayashi Y, Watanabe T, Tamase A, Hayashi Y, Uchiyama N, Nitta H, Hamada JI Neurol Med Chir (Tokyo) 51 386-388 2011/05
  •  Association between carotid plaque composition assessed by multidetector computed tomography and cerebral embolism after carotid stenting Uchiyama N, Misaki K, Mohri M, Hirota Y, Watanabe T, Nakada M, Hayashi Y, Ueda F, Hamada JI Neuroradiology 54 487-493 2012/05
  •  Prediction of high-grade meningioma by preoperative MRI assessment Kawahara Y, Nakada M, Hayashi Y, Kai Y, Hayashi Y, Uchiyama N, Nakamura H, Kuratsu JI, Hamada JI J Neurooncol 108 147-152 2012/05
  •  Silencing of ferrochelatase enhances 5-aminolevulinic acid-based fluorescence and photodynamic therapy efficacy Teng L, Nakada M, Zhao SG, Endo Y, Furuyama N, Nambu E, Pyko IV, Hayashi Y, Hamada JI Br J Cancer 104 798-807 2011/03
  •  Visualization of dominant angiographical arteriovenous shunting in parasylvian glioblastomas Yoshikawa A, Nakada M, Kita D, Watanabe T, Kinoshita M, Miyashita K, Furuta T, Hamada JI, Uchiyama N, Hayashi Y Acta Neurochirurgica 2013/02
  •  Aberrant glycogen synthase kinase 3β is involved in pancreatic cancer cell invasion and resistance to therapy Kitano A, Shimasaki T, Chikano Y, Nakada M, Hirose M, Higashi T, Ishigaki Y, Endo Y, Takino T, Sato H, Sai Y, Miyamoto KI, Motoo Y, Kawakami K, Minamoto T. PLoS One 8 e55289 2013/02
  •  Functional reorganization in the patient with progressing glioma of pure primary motor cortex: A case report with special reference to the topographic central sulcus defined by SEP. Hayashi Y, Nakada M, Kinoshita M, Hamada JI World Neurosurgery 2013/01
  •  Combination therapy using Notch and Akt inhibitors is effective for suppressing invasion but not proliferation in glioma cells Jin R, Nakada M, Teng L, Furuta T, Sabit H, Hayashi Y, Demuth T, Hirao A, Sato H, Zhao G, Hamada JI Neuroscience letters 534 316-321 2012/12
  •  Aberrant signaling pathways in glioma Nakada M, Kita D, Watanabe T, Hayashi Y, Teng L, Pyko IV, Hamada JI Cancers 3 3242-3278 2011/01
  •  Radiation induced cerebellar high grade glioma accompanied by meningioma and cavernoma 29 years after the treatment of medulloblastoma: a case report Kamide T, Nakada M, Hayashi Y, Suzuki T, Hayashi Y, Uchiyama N, Kijima T, Hamada JI J Neurooncol 100 299-303 2010/11
  •  Correlation between language function and the left arcuate fasciculus detected by diffusion tensor imaging tractography after brain tumor surgery Hayashi Y, Kinoshita M, Nakada M, Hamada JI J Neurosurg 117 839-843 2012/11
  •  Secondary anaplastic astrocytoma developing in a young adult with autoimmune lymphoproliferative syndrome (ALPS) Kita D, Hayashi Y, Watanabe T, Korshunov A, von Deimling A, Nakada M, Kinoshita M, Uchiyama N, Kasahara Y, Zen Y, Hamada JI, Hayashi Y Neuropathology and Applied Neurobiology 37 423-427 2011/06
  •  Ependymoma and choroid plexus papilloma as synchronous multiple neuroepithelial tumors in the same patient: a case report and review of literature Hayashi Y, Mohri M, Nakada M, Hamada JI Neurosurgery 68 E1144-1147 2011/04
  •  Sphingosine-1-phosphate receptor type 1 regulates glioma cell proliferation and correlates with survival of patients with glioblastoma. Yoshida Y, Nakada M, Sugimoto N, Harada T, Hayashi Y, Kita D, Uchiyama N, Hayashi Y, Yachie Y, Takuwa Y, Hamada JI. INTERNATIONAL JOURNAL OF CANCER 98 2341-2352 2010/05
  •  The phosphorylation of ephrin-B2 ligand promotes glioma cell migration and invasion Nakada M, Anderson EM, Demuth T, Nakada S, Reavie LB, Drake KL, Hoelzinger DB, Berens ME. INTERNATIONAL JOURNAL OF CANCER 126 1155-1165 2010/05
  •  The correlation between promoter methylation status and the expression level of O6-methylguanine-DNA methyltransferase in recurrent glioma Suzuki T, Nakada M, Yoshida Y, Nambu E, Furuyama N, Kita D, Hayashi Y, Hayashi Y, Hamada JI Jpn J Clin Oncol 41 190-196 2011/02
  •  NKX2.2 suppresses self-renewal of glioma-initiating cells Muraguchi T, Tanaka S, Yamada D, Tamase A, Nakada M, Nakamura H, Hoshii T, Ooshio T, Tadokoro Y, Naka K, Ino Y, Todo T, Kuratsu JI, Saya H, Hamada JI, Hirao A Can Res 71 1135-1145 2011/02
  •  Epithelioid glioblastoma changed to typical glioblastoma: the methylation status of MGMT promoter and 5-ALA fluorescence Tanaka S, Nakada M, Hayashi Y, Nakada S, Kitamura-Sawada S, Furuyama N, Suzuki T, Kamide T, Hayashi Y, Yano S, Hamada JI Brain Tumor Pathol 28 59-64 2011/02
  •  Ganglioglioma of the thoracolumbar spinal cord in a patient with neurofibromatosis type 1: a case report and literature review Hayashi Y, Nakada M, Mohri M, Murakami H, Kawahara N, Hamada JI Pediatr Neurosurg 47 210-213 2011/10
  •  Skull osteohypertrophy as a complication of bone wax Kamide T, Nakada M, Hirota Y, Hayashi Y, Hayashi Y, Uchiyama N, Hamada JI J Clin Neurosci 16 1658-1660 2009/12
  •  An emerging strategy for cancer treatment targeting aberrant glycogen synthase kinase 3b Miyashita K, Nakada M, Shakoori A, Ishigaki Y, Shimasaki T, Motoo Y, Kawakami K, Minamoto T Anti-Cancer Agents in Medicinal Chemistry 9 1114-1122 2009/12
  •  Intraparenchymal pneumocephalus caused by ethmoid sinus osteoma Kamide T, Nakada M, Hayashi Y, Hayashi Y, Uchiyama N, Hamada JI J Clin Neurosci 16 1487-1489 2009/11
  •  Mollaret’s meningitis associated with occipital dermal sinus Shimizu M, Araki R, Niida Y, Nakada M, Yachie A, Kamide T, Yokoyama T, Iwasa T Journal of Pediatrics 155 757 2009/11
  •  Implication of 5-ALA fluorescence of the ventricle wall for postoperative communicating hydrocephalus associated with CSF dissemination in glioblastoma patients - A report of seven cases- Hayashi Y*, Nakada M*, Tanaka S, Uchiyama N, Hayashi Y, Kita D, Hamada JI J Neurosurg 112 1015-1019 2010/05
  •  The expression level of sphingosine-1-phosphate receptor type 1 is related to MIB-1 labeling index and predicts survival of glioblastoma patients Yoshida Y, Nakada M, Harada T, Tanaka S, Furuta T, Hayashi Y, Kita D, Uchiyama N, Hayashi Y, Hamada JI J Neurooncol 98 41-47 2010/05
  •  Retro-odontoid pseudotumor without atlantoaxial subluxation Tanaka S, Nakada M, Hayashi Y, Mohri M, Hayashi Y, Uchiyama N, Hamada JI J Clin Neurosci 17 649-652 2010/05
  •  Force detecting gripper and flexible micro manipulator for neurosurgery Yoneyama T, Watanabe T, Kagawa H, Hamada JI, Hayashi Y, Nakada M. Conf Proc IEEE Eng Med Biol Soc 2011 6695-6699 2011/01
  •  PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas Ozawa T, Brennan CW, Wang L, Squatrito M, Sasayama T, Nakada M, Huse JT, Pedraza A, Utsuki S, Yasui Y, Tandon A, Fomchenko EI, Oka H, Levine RL, Fujii K, Ladanyi M, Holland EC Genes & Development 24 2205-2218 2010/10
  •  Potential effect of glycogen synthase kinase 3 beta inhibition against human glioblastoma Miyashita K, Kawakami K, Nakada M, Mai W, Shakoori A, Fujisawa H, Hayashi Y, Hamada JI, MinamotoT. CLINICAL CANCER RESEARCH 15 3 887-897 2009/02
  •  A case of neurosarcoidosis with necrotizing granuloma expressing angiotensin converting enzyme Kitajima S, Sakai N, Furuichi K, Tomokage M, Hara A, Kitagawa K, Sawada S, Zen Y, Nakada M, Kaneko S, Wada T Mod Rheumatol 20 506-510 2010/10
  •  Transcrusal approach to the retrochiasmatic region with special reference to temporal lobe retraction: An anatomical study. Kinoshita M, Nakada M, Tanaka S, Ozaki N, Hamada JI, Hayashi Y Acta Neurochirurgica 153 659-665 2011/03
  •  The guanine nucleotide exchange factors Trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma Salhia B, Tran NL, Chan A, Wolf A, Nakada M, Ennis M, Rutka F, McDonough WS, Berens ME, Symons M, Rutka JT Am J Pathol 173 1828-1838 2008/12
  •  Ossified peripheral middle cerebral artery aneurysm in a 30-year-old man Hayashi Y, Shima H, Kinoshita M, Nakada M, Miyashita K, Hamada JI J Clin Neurosci 16 1075-1077 2009/08
  •  BCL10 single nucleotide polymorphism and its association with CSF dissemination of primary intracranial germ cell tumors Hayashi Y, Watanabe T, Nakada M, Kita D, Hayashi Y, Uchiyama N, Hamada JI Pediatr Neurosurg 45 291-295 2009/04
  •  Gonadotropin-releasing hormone (GnRH) and its receptor in human meningiomas Hirota Y, Tachibana O, Uchiyama N, Hayashi Y, Nakada M, Kita D, Watanabe T, Higashi R, Hamada JI, Hayashi Y Clinical Neurol and Neurosurg 45 291-295 2009/02
  •  Role of myosin II activity and the regulation of myosin light chain phosphorylation in astrocytomas. 65 1212-1222 2008
  •  A reevaluation of the primary diagnosis of hemangiopericytoma and the clinical importance of differential diagnosis from solitary fibrous tumor of the central nervous system Clinical Neurol and Neurosurg 111 34-38 2009/01
  •  MAP-ing glioma invasion-MKK3 and p38 drive glioma invasion and progression and predict survival. 6 1212-1222 2007
  •  Molecular targets of glioma invasion. Nakada M, Nakada S, Demuth T, Tran NL, Hoelzinger DB, Berens ME 64 4 458-478 2007/02
  •  Role of Rac1-regulated signaling in medulloblastoma invasion Zavarella S, Nakada M, Belverud S, Coniglio SJ, Chan A, Mittler MA, Schneider SJ, Symons M. Journal of Neurosurg: Pediatrics 4 2  97-104 2009/08
  •  Increased Fn14 expression levels promote glioma cell invasion via Rac1 and NF-kappa B and correlate with poor patient outcome. 66 208-215 2006
  •  Autotaxin: a secreted autocrine/paracrine factor that promotes glioma invasion. JOURNAL OF NEURO-ONCOLOGY 86  297-309 2008
  •  Glioma cells on the run, the migratory transcriptome of 10 human glioma cell lines. BMC Genomics 9  54 2008
  •  Association fibers connecting the Broca center and the lateral superior frontal gyrus: a microsurgical and tractographical anatomy Kinoshita M, Shinohara H, Hori O, Ozaki N, Ueda F, Nakada M, Hamada JI, Hayashi Y J Neurosurg 116 323-330 2012/02
  •  Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin Tamase A, Muraguchi T, Naka K, Tanaka S, Kinoshita M, Hoshii T, Ohmura M, Shugo H, Ooshio T, Nakada M, Sawamoto K, Onodera M, Matsumoto K, Oshima M, Asano M, Saya H, Okano H, Suda T, Hamada JI, Hirao A. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME 106 40 17163-17168 2009/09
  •  Human glioblastomas overexpress ADAMTS-5 that degrades brevican. ACTA NEUROPATHOLOGICA 110  239-246 2005
  •  Ephrin-B3 ligand promotes glioma invasion through activation of Rac1. Nakada M, Drake KL, Nakada S, Niska JA, Berens ME CANCER RESEARCH 66  8492-8500 2006/09
  •  Unusual angiographic changes in an internal carotid artery pseudoaneurysm after infection in the deep neck space Hayashi Y, Shima H, Miyashita K, Kinoshita M, Nakada M, Kida S, Hamada JI. NEUROLOGIA MEDICO-CHIRURGICA 48 5 216-9 2008/05
  •  EphB2/R-Ras signaling regulates glioma cell adhesion, growth, and invasion. AMERICAN JOURNAL OF PATHOLOGY 167  565-576 2005/08
  •  Cell migration and invasion assays. METHODS 37  208-215 2005
  •  Recurrent intracranial esthesioneuroblastoma outside the initial field of radiation with progressive dural and intra-orbital invasion. ACTA NEUROCHIRURGICA 146 179-182 2004/05
  •  JSAP1/JIP3 cooperates with FAK to regulate c-Jun N-terminal kinase and cell migration. JOURNAL OF BIOLOGICAL CHEMISTRY 280  37772-37781 2005
  •  Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins. CANCER RESEARCH 63 3364-3369 2003/06
  •  ADAM12 is selectively overexpressed in human glioblastoma and is associated with glioblastoma cell proliferation and shedding HB-EGF. AMERICAN JOURNAL OF PATHOLOGY 165 1743-1753 2004/11
  •  Suppression of MT1-MMP-mediated MMP-2 activation and tumor invasion by testican 3 and its splicing variant gene product N-Tes. CANCER RESEARCH 61 8896-8902 2001/12
  •  Inhibition of Rho-Kinase effects astrocytoma morphology, motility and invasion through activation of Rac1. CANCER RESEARCH 65  8792-8800 2005
  •  Expression of dominant negative form of Ets-1 suppresses fibronectin-stimulated cell adhesion and migration through down-regulation of integrin α5 expression in U251 glioma cell line Cancer Res 61 21 7985-7991 2001/11
  •  Contrast-enhanced fluid-attenuated inversion-recovery MRI is useful to detect the CSF dissemination of glioblastoma J Comput Assist Tomogr 25 6 953-956 2001/11
  •  Roles of membrane type 1 matrix metalloproteinase and tissue inhibitor of metalloproteinases 2 in invasion and dissemination of human malignant glioma J Neurosurg 94 3 464-73 2001/03
  •  Rupture of an aneurysm during three-dimensional computerized tomography angiography J Neurosurg 93 5 900 2000/11
  •  MRI findings of cerebral paragonimiasis in chronic stage Clin Radiol 54 9 622-624 1999/09
  •  Ets-1 positively regulates expression of urokinase-type plasminogen activator (uPA) and invasiveness of astrocytic tumors J Neuropathol Exp Neurol 58 4 329-334 1999/04
  •  Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human astrocytic tumors Am J Pathol 154 2 417-428 1999/02
  •  Sweet's syndrome associated with granulocyte colony-stimulating factor Eur J Dermatol 8 7 503-505 1998/10
  •  Simulation of clipping position for cerebral aneurysms using three-dimensional computed tomography angiography. NEUROLOGIA MEDICO-CHIRURGICA 44 6-13 2004/01
  •  The cluster of arachnoid diverticula in the occipital bone: report of two cases with literature review Acta Neurochir(Wien) 140 7 647-650 1998/07
  •  Role of synaptojanin 2 in glioma cell migration and invasion. CANCER RESEARCH 64 8271-8275 2004/12
  •  CrkI adaptor protein modulates cell migration and invasion in glioblastoma. CANCER RESEARCH 63 2335-2337 2003/05
  •  The phosphorylation of EphB2 receptor regulates migration and invasion of human glioma cells. CANCER RESEARCH 64  3179-3185 2004/07
  •  Contrast-enhanced MRI of intracellar arachnoid cyst: relationship between the pituitary gland and cyst. NEURORADIOLOGY 38 566-568 1996/08
  •  Identification of blood biomarkers in glioblastoma by SWATH mass spectrometry and quantitative targeted absolute proteomics Miyauchi E, Furuta T, Ohtsuki S, Tachikawa M, Uchida Y, Sabit H, Obuchi W, Baba T, Watanabe M, Terasaki T, Nakada M PLOS ONE 13 3 e0193799 2018/03/07
  •  Activation of the receptor tyrosine kinase AXL mediates the immune microenvironment in glioblastoma Sadahiro H, Kang KD, Gibson JT, Minata M, Yu H, Shi J, Chhipa R, Chen Z, Lu S, Simoni Y, Furuta T, Sabit H, Zhang S, Bastola S, Yamaguchi S, Alsheikh HA, Komarova S, Wang J, Kim SH, Hambardzumyan D, Lu X, Newell EW, DasGupta B, Nakada M, Lee LJ, Nabors B, Norian LA, Nakano I Can Res. 2018/03/12
  •  N-myc downstream-regulated gene 2 protects blood-brain barrier integrity following cerebral ischemia Takarada-Iemata M, Yoshikawa A, Hieu TM, Okitani N, Nishiuchi T, Aida Y, Kamide T, Hattori T, Ishii H, Kitao Y, Matsuyama T, Nakada M, Hori O Glia 2018/02/12
  •  CNS high-grade neuroepithelial tumor with BCOR internal tandem duplication: a comparison with its counterparts in the kidney and soft tissue Yoshida Y, Nobusawa S, Nakata S, Nakada M, Arakawa Y, Mineharu Y, Sugita Y, Yoshioka T, Araki A, Sato Y, Okada M, Nishi A, Yamazaki T, Kohashi K, Oda Y, Hirato J, Yokoo H Brain Pathology 2017/12/11
  •  ROCK-dependent phosphorylation of NUP62 regulates p63 nuclear transport and squamous cell carcinoma proliferation Hazawa M, Lin DC, Kobayashi A, Jiang YY, Xu L, Dewi F, Mohamed M, Hartono H, Nakada M, Meguro-Horike M, Horike S, Koeffler HP, Wong R EMBO Reports 19 73-88 2018
  •  Descent of the anterior communicating artery after removal of pituitary macroadenoma using transsphenoidal surgery Hayashi Y, Sasagawa Y, Fukui I, Oishi M, Kita D, Misaki K, Kozaka K, Tachibana O, Nakada M Surg Neurol Int 8 306 2017
  •  Physical risk factors of hemorrhagic complications associated with Angio-Seal closure device use in neurointerventional procedures Aida Y, Misaki K, Kamide T, Mohri M, Uchiyama N, Nakada M World Neurosurgery 2018/01/08
  •  High pressure in virtual post-coiling model is a predictor of internal carotid artery aneurysm recurrence after coiling Nambu I, Misaki K, Uchiyama N, Mohri M, Suzuki T, Takao H, Murayama Y, Futami K, Kawamura T, Inoguchi Y, Matsuzawa T, Nakada M. Neurosurgery  2018/03/15
  •  Objective evaluation of cerebrovascular reactivity for acetazolamide predicts cerebral hyperperfusion after carotid artery stenting: Comparison with region of interest methods Misaki K, Uchiyama N, Inaki A, Kinuya S, Nambu I, Kamide T, Mohri M, Hayashi Ya, Nakada M J Neuroradiol  2018/03/07
  •  Outcome of diabetes insipidus in patients with Rathke cleft cysts Oishi M, Hayashi Y, Sasagawa Y, Kita D, Tachibana O, Nakada M Clin Neurol Neurosurg 2018/02/21
  •  Neural networks mediating high-level mentalizing in patients with right cerebral hemispheric gliomas Nakajima R, Kinoshita M, Okita H, Yahata T, Matsui M, Nakada M Front Behav Neurosci  12 33 2018
  •  Contribution of intrasellar pressure elevation to headache manifestation in pituitary adenoma evaluated with intraoperative pressure measurement Hayashi Y, Sasagawa Y, Oishi M, Kita D, Misaki K, Fukui I, Tachibana O, Nakada M Neurosurgery  2018/03/29
  •  Clinicopathological and genetic association between epithelioid glioblastoma and pleomorphic xanthoastrocytoma Furuta T, Miyoshi H, Komaki S, Arakawa F, Morioka M, Ohshima K, Nakada M, Sugita Y Neuropathol. 2018/03/13
  •  A case of a mobile choroid plexus cyst presenting with different types of obstructive hydrocephalus Tamai S, Hayashi Y, Sasagawa Y, Oishi M, Nakada M Surg Neurol Int  9 47 2018
  •  Delayed occurrence of diabetes insipidus following transsphenoidal surgery with radiological evaluation of the pituitary stalk on magnetic resonance imaging Hayashi Y, Aida Y, Sasagawa Y, Oishi M, Kita D, Tachibana O, Ueda F, Nakada M World Neurosurgery 110 e1072-e1077 2018
  •  Damage of the right dorsal superior longitudinal fascicle by awake surgery for glioma causes persistent visuospatial dysfunction Nakajima R, Kinoshita M, Miyashita K, Okita H, Genda R, Yahata T, Hayashi Y, Nakada M Sci Rep 7 17158 2017
  •  In vivo imaging xenograft models for the evaluation of anti-brain-tumor efficacy of targeted drugs Kita K, Arai1 S, Nishiyama A, Taniguchi H, Fukuda K, Wang R, Yamada T, Takeuchi S, Tange S, Tajima A, Nakada M, Yasumoto K, Motoo Y, Murakami T, Yano S Cancer Medicine 6 2972-2983 2017
  •  Long spinal cord lesions in a patient with pathologically proven multiple sclerosis Komatsu J, Sakai K, Nakada M, Iwasa K, Yamada M Journal of Clinical Neuroscience 42 106-108 2017
  •  Multiple sclerosis showing elevation of adenosine deaminase levels in the cerebrospinal fluid. Samuraki M, Sakai K, Odake Y, Yoshita M, Misaki K, Nakada M, Yamada M Mult Scler Relat Disord 13  44-46 2017
  •  Force-visualized silicone retractor attachable to surgical suction pipes Watanabe T, Koyama T, Yoneyama T, Nakada M Sensors (Basel)  17 2017
  •  Genome-wide methylation profiles in primary intracranial germ cell tumors indicate a primordial germ cell origin for germinomas Fukushima S, Yamashita S, Kobayashi H, Takami H, Fukuoka K, Nakamura T, Yamasaki K, Matsushita Y, Nakamura H, Totoki Y, Kato M, Suzuki T, Mishima K, Yanagisawa T, Mukasa A, Saito N, Kanamori M, Kumabe T, Tominaga T, Nagane M, Iuchi T, Yoshimoto K, Mizoguchi M, Tamura K, Sakai K, Sugiyama K, Nakada M, Yokogami K, Takeshima H, Kanemura Y, Matsuda M, Matsumura A, Kurozumi K, Ueki K, Nonaka M, Asai A, Kawahara N, Hirose Y, Takayama T, Nakazato Y, Narita Y, Shibata T, Matsutani M, Ushijima T, Nishikawa R, Ichimura K; Intracranial Germ Cell Tumor Genome Analysis Consortium (The iGCTConsortium) Acta Neuropathologica 133 445-462 2017
  •  MR spectroscopy to distinguish between supratentorial intraventricular subependymoma and central neurocytoma Ueda F, Aburano H, Ryu Y, Yoshie Y, Nakada M, Hayashi Y, Matsui O, Gabata T Magn Reson Med Sci 16 223-230 2017
  •  Fluorescence intensity and bright spot analyses using confocal microscope for photodynamic diagnosis of brain tumors Yoneyama T, Watanabe T, Kagawa H, Hayashi Y, Nakada M Photodiagnosis Photodyn Ther 17 13-21 2017
  •  Inflow hemodynamics evaluated by using four-dimensional flow magnetic resonance imaging and the size ratio of unruptured cerebral aneurysms Futami K, Nambu I, Kitabayashi T, Misaki K, Uchiyama N, Ueda F, Nakada M Neuroradiology  59 411-418 2017
  •  Biological basis and clinical trial of glycogen synthase kinase-3β-targeted therapy by drug repositioning for glioblastoma Furuta T, Sabit H, Yu D, Miyashita K, Kinoshita M, Uchiyama N, Hayashi Y, Hayashi Y, Minamoto T, Nakada M Oncotarget 8 22811-22824 2017
  •  Identification of antipsychotic drug fluspirilene as a potential anti-glioma stem cell drug Dong Y, Furuta T, Sabit H, Kitabayashi T, Jiapaer S, Kobayashi M, Ino Y, Todo T, Teng L, Hirao A, Zhao SG, Nakada M Oncotarget 8 111728-111741 2017
  •  Intraoperative Rupture of Unruptured Cerebral Aneurysm during Craniotomy: A Case Report Yoshiki K, Misaki K, Nambu I, Fukui I, Mohri M, Uchiyama N, Nakada M Case Rep Neurol 9 261–266 2017
  •  Radiation-induced gliomas: a report of four cases and analysis of molecular biomarkers Nakao T, Sasagawa Y, Nobusawa S, Takabatake Y, Sabit H, Kinoshita M, Miyashita K, Hayashi Y, Yokoo H, Nakada M Brain Tumor Pathol 34 10 149-154 2017
  •  Concurrent cervical dural and multiple perimedullary arteriovenous fistulas presenting with subarachnoid hemorrhage: The source of bleeding was invisible at initial angiography Nambu I. Uchiyama N, Misaki K, Mohri M, Nakada M Surgical Neurology International 8 2 2017
  •  Clinical characteristics of acromegalic patients with empty sella and their outcomes following transsphenoidal surgery Sasagawa Y, Hayashi Y, Tachibana O, Oishi M, Fukui I, Iizuka H, Nakada M Pituitary 20 4 403-408 2017
  •  Unique venous drainage of a sphenoid wing dural arteriovenous fistula with ocular symptoms Misaki K, Uchiyama N, Mohri M, Aida Y, Uno T, Nakada M World Neurosurg 97 753.e1-753.e5 2017
  •  Delayed occurrence of diabetes insipidus following transsphenoidal surgery with radiological evaluation of the pituitary stalk on magnetic resonance imaging Hayashi Y, Aida Y, Sasagawa Y, Oishi M, Kita D, Tachibana O, Ueda F, Nakada M World Neurosurgery 2017
  •  Contribution of sellar dura integrity to symptom manifestation in pituitary adenomas with intratumoral hemorrhage Hayashi Y, Sasagawa Y, Kita D, Fukui I, Oishi M, Tachibana O, Nakada M Pituitary  20 5 531-538 2017
  •  Preoperative evaluation of the interface between tuberculum sellae meningioma and the optic nerves on fast imaging with steady-state acquisition for extended endoscopic endonasal transsphenoidal surgery Hayashi Y, Kita D, Fukui I, Sasagawa Y, Oishi Y, Tachibana O, Ueda F, Nakada M. World Neurosurgery  103 153-160 2017
  •  Rathke cleft cyst with entirely ossified cyst wall and partially solid cyst content: a case report and literature review World Neurosurgery 98 e15-882,e20 2017
  •  MR spectroscopy to distinguish between supratentorial intraventricular subependymoma and central neurocytoma. Ueda F, Aburano H, Ryu Y, Yoshie Y, Nakada M, Hayashi Y, Matsui O, Gabata T. Magn Reson Med Sci. 2016
  •  High efficacy of third generation EGFR inhibitor AZD9291 in a leptomeningeal carcinomatosis model with EGFR-mutant lung cancer cells. Nanjo S, Ebi H, Arai S, Takeuchi S, Yamada T, Mochizuki S, Okada Y, Nakada M, Murakami T, Yano S. Oncotarget  7 3847-3856 2016
  •  Fluorescence intensity and bright spot analyses using confocal microscope for photodynamic diagnosis of brain tumors  Yoneyama T, Watanabe T, Kagawa H, Hayashi Y, Nakada M Photodiagnosis Photodyn Ther.  2016
  •  miR-150-5p and miR-133a suppress glioma cell proliferation and migration through targeting membrane-type-1 matrix metalloproteinase. Sakr M, Takino T, Sabit H, Nakada M, Li Z, Sato H Gene  587 155-62 2016
  •  Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-κB pathway. Takino T, Nakada M, Li Z, Yoshimoto T, Domoto T, Sato H. Clin Exp Metastasis 33 45-52 2016
  •  Establishment of anti-human ATRX monoclonal antibody AMab-6 Ogasawara S, Fujii Y, Kaneko MK, Oki H, Sabit H, Nakada M, Suzuki H, Ichimura K, Komori T, Kato Y. Monoclon Antib Immunodiagn Immunother.  35 254-258 2016
  •  Glycogen synthase kinase-3β is a pivotal mediator of cancer invasion and resistance to therapy Domoto T, Pyko IV, Furuta T, Miyashita K, Uehara M, Shimasaki T, Nakada M, Minamoto T. Cancer Sci.  107 1363-1372  2016
  •  The role of AKT isoforms in glioblastoma: AKT3 delays tumor progression. Joy A, Kapoor M, Georges J, Butler L, Chang Y, Li C, Crouch A, Smirnov I, Nakada M, Hepler J, Marty M, Feuerstein BG. J Neurooncol.  130 43-52, 2016
  •  Force-sensible silicone retractor for attachment to surgical suction pipes. Watanabe T, Koyama T, Yoneyama T, Nakada M Sensors (Basel) 16 2016
  •  Recurrent neomorphic mutations of MTOR in central nervous system and testicular germ cell tumors may be targeted for therapy" Ichimura K, Fukushima S, Totoki Y, Matsushita Y, Otsuka A, Tomiyama A, Niwa T, Takami H, Nakamura T, Suzuki T, Fukuoka K, Yanagisawa T, Mishima K, Nakazato Y, Hosoda F, Narita Y, Shibui S, Yoshida A, Mukasa A, Saito N, Kumabe T, Kanamori M, Tominaga T, Kobayashi K, Shimizu S, Nagane M, Iuchi T, Mizoguchi M, Yoshimoto K, Tamura K, Maehara T, Sugiyama K, Nakada M, Sakai K, Kanemura Y, Nonaka M, Asai A, Yokogami K, Takeshima H, Kawahara N, Takayama T, Yao M, Kato M, Nakamura H, Hama N, Sakai R, Ushijima T, Matsutani M, Shibata T, Nishikawa R, Intracranial Germ Cell Tumor Genome Analysis Consortium (iGCT Consortium) Acta Neuropathologica 131: 889-901, 2016 131 889-901 2016
  •  Serine/Threonine kinase MLK4 determines Mesenchymal Identity in Glioma Stem Cells in an NFkB-dependent manner Kim SH, Ezhilarasan R, Chhipa R, Ladner K, Phillips E, Sparks A, Taylor D, Furuta T, Sabit H, Kurozumi K, Kuroiwa T, Akio A, Gallego-Perez1 D, Sulman EP, Cheng S, Lee J, Nakada M, Guttridge D, DasGupta B, Goidts V, Bhat KP, Walker J, Nakano I. Cancer Cell  29 201-213 2016
  •  Critical neural networks in awake surgery for gliomas. Kinoshita M, Miyashita K, Tsutsui T, Furuta T, Nakada M Neurol Med Chir (Tokyo)  56 674-686 2016
  •  Chronic spatial working memory deficit associated with the superior longitudinal fasciculus: a study using voxel-based lesion-symptom mapping and intraoperative direct stimulation in the right prefrontal glioma surgery Kinoshita M, Nakajima R, Shinohara H, Miyashita K, Tanaka S, Okita H, Nakada M , Hayashi Y. J Neurosurg  125 1024-1032 2016
  •  Rathke cleft cyst with entirely ossified cyst wall and partially solid cyst content: a case report and literature review. Hayashi Y, Oishi M, Fukui I, Kita D, Sasagawa Y, Aida Y, Tachibana O, Nakada M  World Neurosurgery
  •  Pseudoaneurysm formation caused by the withdrawal of a Trevo ProVue stent at a tortuous cerebral vessel: a case report Misaki K, Uchiyama N, Mohri M, Kamide T, Tsutsui T, Kanamori N, Kurokawa K, Nakada M Acta Neurochirurgica 158 2085-2088 2016
  •  Intracranial aneurysm formation after radiotherapy for medulloblastoma. Kamide T, Mohri M, Misaki K, Uchiyama N, Nakada M Surg Neurol Int  7 S880-S882 2016
  •  Volumetric growth analysis of an insular dysembryoplastic neuroepithelial tumor over a 10-year follow-up Uno T, Kinoshita M, Furuta T, Miyashita K, Sabit H, Nakada M Surg Neurol Int  7  S1154-1157  2016
  •  Acute progression of recurrent meningioma during luteinizing hormone-releasing hormone agonist treatment for prostate cancer Tsutsui T, Miyashita K, Sabit H, Fukui I, Hayashi Y, Mizokami A, Ikeda H, Nagatani H, Nakada M World Neurosurg  91 670 e1-6 2016
  •  Simultaneous ventriculoperitoneal shunt removal and endoscopic third ventriculostomy for three patients previously treated for intracranial germ cell tumors more than 20 years ago Kita D, Hayashi Y, Fukui I, Oishi M, Nakada M Child's Nervous System 32 1543-7 2016
  •  Carotid artery protrusion and dehiscence in patients with acromegaly Sasagawa Y, Tachibana O, Doai M, Hayashi Y, Tonami H, Iizuka H, Nakada M. Pituitary  19: 482-7 2016
  •  Midline dural filum of the sellar floor; its relationship to the septum attachment to the sellar floor and the ossification in the sphenoid sinus Hayashi Y, Kita D, Iwato M, Fukui I, Sasagawa Y, Oishi M, Tachibana O, Nakada M. Clin Neurol Neurosurg  147 53-58 2016
  •  Xanthomatous hypophysitis associated with autoimmune disease in an elderly patient: A rare case report Oishi M, Hayashi Y, Fukui I, Kita D, Miyamori T, Nakada M Surg Neurol Int  7 S449-453  2016
  •  Simple classification of carotid bifurcation: is it possible to predict twisted carotid artery during carotid endarterectomy? Kamide T, Nomura M, Tamase A, Mori K, Seki S, Kitamura Y, Nakada M. Acta Neurochirurgica (Wien)  158  2393-2397  2016
  •  Prediction of postoperative diabetes insipidus using morphological hyperintensity patterns in the pituitary stalk on magnetic resonance imaging after transsphenoidal surgery for sellar tumors Hayashi Y, Kita D, Watanabe T, Fukui I, Sasagawa Y, Oishi M, Tachibana O, Ueda F, Nakada M. Pituitary  19 552-559 2016
  •  Treatment result of in the initial stage of Kanazawa Mobile Embolectomy Team for acute ischemic stroke Uchiyama N, Misaki K, Mohri M, Kamide T, Hirota Y, Higashi R, Minamide H, Kohda Y, Asahi T, Shoin K, Iwato M, Kita D, Hamada H, Yoshida Y, Nakada M. Neurol Med Chir (Tokyo)  56 737-744 2016
  •  Pediatric symptomatic Rathke cleft cyst compared to cystic craniopharyngioma Hayashi Y, Kita D, Fukui I, Sasagawa Y, Oishi M, Okajima M, Tachibana O, Nakada M. Child's Nervous System 32 1625-32 2016
  •  Optimizing the volume of the initial framing coil to facilitate tight packing of intracranial aneurysms Misaki K, Uchiyama N, Nambu I, Aida Y, Kamide T, Mohri M, Ueda F, Nakada M World Neurosurg  90 397-402 2016
  •  Inflow jet patterns of unruptured cerebral aneurysms based on flow velocity of the parent artery: evaluation using 4D flow MRI. Futami K, Shimizu Y, Kitabayashi T, Sano H, Misaki K, Uchiyama N, Ueda F, Nakada M.  37 2016
  •  Prediction of carotid artery in-stent restenosis by quantitative assessment of vulnerable plaque using computed tomography.  Misaki K, Uchiyama N, Mohri M, Hayashi Y, Ueda F, Nakada M J Neuroradiol 43: 18-24, 2016  43 18-24 2016
  •  Ligand-dependent EphB1 signaling suppresses glioma invasion and correlates with patient survival Teng, Lei; Nakada, Mitsutoshi; Furuyama, Natsuki; Sabit, Hemragul; Furuta, Takuya; Hayashi, Yutaka; Takino, Takahisa; Dong, Yu; Sato, Hiroshi; Sai, Yoshimichi; Miyamoto, Kenichi; Berens, Michael E.; Zhao, Shiguang; Hamada, Junichiro Neuro-Oncology 15 12 1710-1720 2013/12/01 
  •  Strong therapeutic potential of γ-secretase inhibitor MRK003 for CD44-high and CD133-low glioblastoma initiating cells Tanaka, Shingo; Nakada, Mitsutoshi; Yamada, Daisuke; Nakano, Ichiro; Todo, Tomoki; Ino, Yasushi; Hoshii, Takayuki; Tadokoro, Yuko; Ohta, Kumiko; Ali, Mohammed Aamir E; Hayashi, Yutaka; Hamada, Junichiro; Hirao, Atsushi Journal of Neuro-Oncology 2014/10/08 
  •  Prognostic paradox: Brain damage around the glioblastoma resection cavity Furuta, Takuya; Nakada, Mitsutoshi; Ueda, Fumiaki; Watanabe, Takuya; Arakawa, Yasuaki; Higashi, Ryo; Hashimoto, Masaaki; Nitta, Hisashi; Hayashi, Yutaka; Hamada, Junichiro Journal of Neuro-Oncology 118 1 187-192 2014/01/01 
  •  Functional reorganization in the patient with progressing glioma of the pure primary motor cortex: A case report with special reference to the topographic central sulcus defined by somatosensory-evoked potential Hayashi, Yutaka; Nakada, Mitsutoshi; Kinoshita, Masashi; Hamada, Junichiro World Neurosurgery 82 3 5360-5360000 2014/01/01 
  •  Awake surgery with line bisection task for two cases of parietal glioma in the non-dominant hemisphere Kitabayashi, Tomohiro; Nakada, Mitsutoshi; Kinoshita, Masashi; Sakurai, Hiroyuki; Kobayashi, Saori; Okita, Hirokazu; Nanbu, Yuko; Hayashi, Yutaka; Hamada, Junichiro Neurological Surgery 40 12 1087-1093 2012/12/01 
  •  Receptor tyrosine kinases: Principles and functions in glioma invasion Nakada, Mitsutoshi; Kita, Daisuke; Teng, Lei; Pyko, Ilya V.; Watanabe, Takuya; Hayashi, Yutaka; Hamada, Junichiro Advances in Experimental Medicine and Biology 986 143-170 2013/01/01 
  •  Neurolymphomatosis exhibiting repeated exacerbation and remission in both the peripheral and central nervous systems Akagi, Akio; Ono, Kenjiro; Hamaguchi, Tsuyoshi; Samuraki, Miharu; Nakada, Mitsutoshi; Shima, Yukiko; Oohata, Tetuya; Yamada, Masahito Journal of the Neurological Sciences 345 1 267-268 2014/01/01 
  •  Molecular analysis of a recurrent glioblastoma treated with bevacizumab Furuta, Takuya; Nakada, Mitsutoshi; Misaki, Kouichi; Sato, Yasunori; Hayashi, Yutaka; Nakanuma, Yasuni; Hamada, Junichiro Brain Tumor Pathology 31 1 32-39 2014/01/01 
  •  Neuro-Sweet disease mimicking recurrent anaplastic astrocytoma associated with therapy-related myelodysplastic syndrome: A case report Shimizu, Yu; Watanabe, Takuya; Nakada, Mitsutoshi; Hayashi, Yutaka; Hamaguchi, Yasuhito; Sugimori, Naomi; Hamada, Junichiro Clinical Neurology and Neurosurgery 114 7 1049-1051 2012/09/01 
  •  Direct evidence for the causal role of the left supplementary motor area in working memory: A preliminary study Nakajima, Riho; Okita, Hirokazu; Kinoshita, Masashi; Miyashita, Katsuyoshi; Nakada, Mitsutoshi; Yahata, Tetsutaro; Hamada, Junichiro; Hayashi, Yutaka Clinical Neurology and Neurosurgery 126 201-204 2014/01/01 
  •  Ganglioglioma of the thoracolumbar spinal cord in a patient with neurofibromatosis type 1: A case report and literature review Hayashi, Yutaka; Nakada, Mitsutoshi; Mohri, Masanao; Murakami, Hideki; Kawahara, Norio; Hamada, Junichiro Pediatric Neurosurgery 47 3 210-213 2012/01/01 
  •  MGMT promoter methylation and temozolomide response in choroid plexus carcinoma Misaki, Kouichi; Nakada, Mitsutoshi; Mohri, Masanao; Hayashi, Yutaka; Hamada, Junichiro Brain Tumor Pathology 28 3 259-263 2011/07/01 
  •  Epithelioid glioblastoma arising from pleomorphic xanthoastrocytoma with the BRAF V600E mutation Tanaka, Shingo; Nakada, Mitsutoshi; Nobusawa, Sumihito; Suzuki, Satoshi O.; Sabit, Hemragul; Miyashita, Katsuyoshi; Hayashi, Yutaka Brain Tumor Pathology 31 3 172-176 2014/01/01 
  •  Reversible acute bilateral blindness resulting from a frontal brain tumor: A case report Hayashi, Koji; Nakada, Mitsutoshi; Miyashita, Katsuyoshi; Hayashi, Yutaka; Hamada, Junichiro British Journal of Neurosurgery 28 6 793-795 2014/01/01 
  •  Characterizing invading glioma cells based on IDH1-R132H and Ki-67 immunofluorescence Sabit, Hemragul; Nakada, Mitsutoshi; Furuta, Takuya; Watanabe, Takuya; Hayashi, Yutaka; Sato, Hiroshi; Kato, Yukinari; Hamada, Junichiro Brain Tumor Pathology 31 4 242-246 2014/01/01 
  •  Association between carotid plaque composition assessed by multidetector computed tomography and cerebral embolism after carotid stenting Uchiyama, Naoyuki; Misaki, Kouichi; Mohri, Masanao; Watanabe, Takuya; Hirota, Yuichi; Nakada, Mitsutoshi; Hayashi, Yutaka; Ueda, Fumiaki; Hamada, Junichiro Neuroradiology 54 5 487-493 2012/05/01 
  •  PCDH10 is required for the tumorigenicity of glioblastoma cells Echizen, Kanae; Nakada, Mitsutoshi; Hayashi, Tomoatsu; Sabit, Hemragul; Furuta, Takuya; Nakai, Miyuki; Koyama-Nasu, Ryo; Nishimura, Yukiko; Taniue, Kenzui; Morishita, Yasuyuki; Hirano, Shinji; Terai, Kenta; Todo, Tomoki; Ino, Yasushi; Mukasa, Akitake; Takayanagi, Shunsaku; Ohtani, Ryohei; Saito, Nobuhito; Akiyama, Tetsu Biochemical and Biophysical Research Communications 444 1 13-18 2014/01/31 
  •  Recurrent anaplastic meningioma treated by sunitinib based on results from quantitative proteomics Yoshikawa, Akifumi; Nakada, Mitsutoshi; Ohtsuki, Sumio; Hayashi, Yasuhiko; Obuchi, Wataru; Sato, Yasunori; Ikeda, Chiemi; Watanabe, T.; Kawahara, Yosuke; Hasegawa, Takeshi; Sabit, Hemragul; Kita, Daisuke; Hayashi, Yutaka; Nakanuma, Yasuni; Terasaki, Tetsuya; Hamada, Junichiro Neuropathology and Applied Neurobiology 38 1 105-110 2012/02/01 
  •  Aberrant signaling pathways in Glioma Nakada, Mitsutoshi; Kita, Daisuke; Watanabe, Takuya; Hayashi, Yutaka; Teng, Lei; Pyko, Ilya V.; Hamada, Junichiro Cancers 3 3 3242-3278 2011/09/01 
  •  Identification of the inflow zone of unruptured cerebral aneurysms: Comparison of 4D flow MRI and 3D TOF MRA data Futami, Kazuya; Sano, Hirotoshi; Misaki, Kouichi; Nakada, Mitsutoshi; Ueda, Fumiaki; Hamada, Junichiro American Journal of Neuroradiology 35 7 1363-1370 2014/01/01 
  •  Transcrusal approach to the retrochiasmatic region with special reference to temporal lobe retraction: an anatomical study Kinoshita, Masashi;Nakada, Mitsutoshi;Tanaka, Shingo;Ozaki, Noriyuki;Hamada, Jun-ichiro;Hayashi, Yutaka ACTA NEUROCHIRURGICA 153 3 659-665 2011
  •  Anaplastic Meningioma With Extremely Rapid Recurrence-Case Report Kawahara, Yosuke;Nakada, Mitsutoshi;Hayashi, Yutaka;Watanabe, Takuya;Tamase, Akira;Hayashi, Yasuhiko;Uchiyama, Naoyuki;Nitta, Hisashi;Hamada, Jun-ichiro NEUROLOGIA MEDICO-CHIRURGICA 51 5 386-388 2011
  •  Ependymoma and Choroid Plexus Papilloma as Synchronous Multiple Neuroepithelial Tumors in the Same Patient: A Case Report and Review of Literature Hayashi, Yutaka;Mohri, Masanao;Nakada, Mitsutoshi;Hamada, Jun-ichiro NEUROSURGERY 68 4 E1144-E1147 2011
  •  NKX2.2 Suppresses Self-Renewal of Glioma-Initiating Cells Muraguchi, Teruyuki;Tanaka, Shingo;Yamada, Daisuke;Tamase, Akira;Nakada, Mitsutoshi;Nakamura, Hideo;Hoshii, Takayuki;Ooshio, Takako;Tadokoro, Yuko;Naka, Kazuhito;Ino, Yasushi;Todo, Tomoki;Kuratsu, Jun-ichi;Saya, Hideyuki;Hamada, Jun-ichiro;Hirao, Atsushi CANCER RESEARCH 71 3 1135-1145 2011
  •  The mechanism of chemoresistance against tyrosine kinase inhibitors in malignant glioma Nakada, Mitsutoshi; Kita, Daisuke; Watanabe, Takuya; Hayashi, Yutaka; Hamada, Junichiro Brain Tumor Pathology 31 3 198-207 2014/01/01 
  •  Role of Eph/ephrin tyrosine kinase in malignant glioma Nakada, Mitsutoshi; Hayashi, Yutaka; Hamada, Junichiro Neuro-Oncology 13 11 1163-1170 2011/11/01 
  •  Force-detecting gripper and force feedback system for neurosurgery applications Yoneyama, Takeshi;Watanabe, Tetsuyou;Kagawa, Hiroyuki;Hamada, Junichiro;Hayashi, Yutaka;Nakada, Mitsutoshi INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY 8 5 819-829 2013 
  •  Right superior longitudinal fasciculus: Implications for visuospatial neglect mimicking Gerstmann's syndrome Hayashi, Yutaka; Kinoshita, Masashi; Furuta, Takuya; Watanabe, Takuya; Nakada, Mitsutoshi; Hamada, Junichiro Clinical Neurology and Neurosurgery 115 6 775-777 2013/06/01 
  •  The Correlation between Promoter Methylation Status and the Expression Level of O-6-Methylguanine-DNA Methyltransferase in Recurrent Glioma Suzuki, Tomohide;Nakada, Mitsutoshi;Yoshida, Yuya;Nambu, Emi;Furuyama, Natsuki;Kita, Daisuke;Hayashi, Yutaka;Hayashi, Yasuhiko;Hamada, Jun-ichiro JAPANESE JOURNAL OF CLINICAL ONCOLOGY 41 2 190-196 2011

Conference Presentations

Arts and Fieldwork

Patent

Theme to the desired joint research

○The molecular analysis of malignant glioma
○The molecular mechanism of glioma invasion
○Molecular targeted therapy for malignant glioma
○The developement of apparatus for neurosurgery
○localization of brain function

Grant-in-Aid for Scientific Research

○「新規細胞外マトリックス分解酵素阻害分子による神経膠芽腫」(2002-) 
○「神経膠芽腫の浸潤に関与する転写因子と細胞外マトリックス」(2002-) 
○「Eph/ephrinバイオロジーと神経膠腫浸潤」(2007-2008) 
○「グリオーマ幹細胞の浸潤関連分子の同定と機能解析」(2009-2010) 
○「膜型マトリックスメタロプロテアーゼ-1のがん悪性化形質に果たす役割の解析」(2009-) 
○「グリオーマ幹細胞の浸潤関連分子の同定と機能解析」(2009-2010) 
○「次世代プロテオミクスによる悪性グリオーマのバイオマーカー 探索 」(2016-) 
○「悪性グリオーマの浸潤シグナルを狙った分子標的療法の確立」(2011-2013) 
○「ドラッグリポジショニングによる悪性グリオーマに対する新規化学療法の基盤構築」(2014-2016) 
○「標的タンパク発現プロファイルに基づく新規膠芽腫分類の試み」(2014-2015) 
○「標的タンパク発現プロファイルに基づく新規膠芽腫分類の試み」(2014-2015)
○「ドラッグリポジショニングによる悪性グリオーマに対する新規化学療法の基盤構築」(2014-2016)
○「次世代プロテオミクスによる悪性グリオーマのバイオマーカー探索」(2016-2017) 

Classes (Bachelors)

○Neurosurgery(BSL)(2017)
○Neurosurgery(BSL)(2017)
○Cranial Nerves & Sensory Organ(2017)
○Cranial Nerves & Sensory Organ(2016)
○Neurosurgery(BSL)(2016)

Classes (Graduate Schools)

○Neurosurgery(2017)
○Neurosurgery(2017)
○Neurosurgery(2017)
○Medical Sciences(2016)
○Neurosurgery(2016)
○Neurosurgery(2016)
○Neurosurgery(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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