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Researcher Information

last modified:2019/03/29

Professor HARADA Kenichi

Mail Laboratory Website
Laboratory Website

Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences Department of Human Pathology

College and School Educational Field

Division of Cancer Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Human Pathology TEL:076-265-2195 FAX:076-234-4229

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor 199603 Completed
【Academic background(Bachelor's Degree)】
Kanazawa University 199103
【Degree】
Ph.D. (Medicine)

Career

Kanazawa University(1997/06/01-2007/01/31)
Kanazawa University Human Pathology(2007/02/01-)
Kanazawa University Human Pathology(2014/05/01-)

Year & Month of Birth

1966/12

Academic Society





The Clinical Electron Microscopy Society of Japan





Award






○Kanehara Ichiro Kinen
○Hokkoku Gan Kikin(2002)
○Taisho Toyama Award(2006)
○Academic Research Award of The Japanese Society of Pathology(2008/11/21)
○6th Juzen Medical Award(2010/07/09)
○6th Juzen Medical Award(2010/07/09)
○6th Juzen Medical Award(2010/07/09)
○6th Juzen Medical Award(2010/07/09)

Specialities

Human pathology、Experimental pathology、Immunology

Speciality Keywords

Liver, Pathology, Immunology

Research Themes

Pathology of the liver

I conduct basic analysis for pathological analysis and treatment strategies of hepatobiliary system diseases based on hepatic and biliary cell physiology and hepatic immunity analysis.

Immunology of the liver

Liver cancer

Books

  •  Kenichi Harada Biliary Diseases with Pancreatic Counterparts NOVA 2017
  •  Kenichi Harada Pathology of the Bile Duct  Springer 2017
  •  Kenichi Harada, Yoshifumi Ubara IgG4-Related Kidney Diseases  Springer 2016
  •  Kenichi Harada The Liver in Systemic Diseases  (Hiromasa Ohira Editor)   Chapter 15    IgG4-Related Diseases and the liver  Springer 2016
  •  Harada K, Nakanuma Y IgG4-Related Disease Sclerosing Cholangitis  Springer Japan 2014

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  •  Mechanisms of the Sclerosing Cholangiopathy in Biliary Atresia: Association with Biliary Innate Immunity and Epithelial-Mesenchymal Transition Kodansha Shuppan Service Center 2009/11

Papers

  •  Biliary Innate Immunity in the Pathogenesis of Biliary Diseases  1 9 83-90
  •  Biliary Innate Immunity:Function and Modulation Nakanuma Y Volume 2010, Article
  •  Cell-kinetic study of proliferating bile ductules in various hepatobiliary diseases LIVER 18 4 277-284 1998/04
  •  Distribution of apoptotic cells and expression of apoptosis-related proteins along the intrahepatic biliary tree in normal and non-biliary diseased liver HISTOPATHOLOGY 37 4 347-354 2000/04
  •  Enhanced apoptosis relates to bile duct loss in primary biliary cirrhosis HEPATOLOGY 26 6 1399-1405 1997/12

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  •  Enhanced expression of basement-membrane-type heparan sulfate proteoglycan in tumor fibromyxoid stroma of intrahepatic cholangiocarcinoma Pathol Int 51 4 248-256 2001/04
  •  Epithelioid cell granulomas in chronic hepatitis C: Immunohistochemical character and histological marker of favourable response to interferon alpha therapy HISTOPATHOLOGY 33 3 216-221 1998/03
  •  Frequent molecular identification of Campylobacter but not Helicobacter genus in bile and biliary epithelium in hepatholithiasis J Pathol 193 2 218-223 2001/02
  •  Human Reg l is up-regulated in intrahepatic cholangiocarcinoma and its precursor lesions HEPATOLOGY 33 5 1036-1042 2001/05
  •  In situ nucleic acid detection of PDC-E2, BCOADC-E2 OGDC-E-2, PDC-E l alpha, BCOADC-E l alpha, and the E3 binding protein (Protein X) in primary biliary cirrhosis HEPATOLOGY 30 1 36-45 1999/01
  •  In situ nucleic acid hybridization of cytokines in primary biliary cirrhosis: predominance of the Th1 subset HEPATOLOGY 25 4 791-796 1997/04
  •  In situ nucleic acid hybridization of pyruvate dehydrogenase complex-E2 in primary biliary cirrhosis: pyruvate dehydrogenase complex-E2 messenger RNA is expressed in hepatocytes but not in biliary epithelium HEPATOLOGY 25 1 27-32 1997/01
  •  Increased expression of WAF1 in intrahepatic bile ducts in primary biliary cirrhosis relates to apoptosis J Hepatol 34 4 500-506 2001/04
  •  Molecular identification of bacterial 16S ribosomal RNA gene in liver tissue of primary biliary cirrhosis: Is Propionibacterium acnes involved in granuloma formation ? HEPATOLOGY 33 3 530-536 2001/03
  •  PCR and in situ hybridization studies of telomerase subunits in human non-neoplsatic livers J Pathol 193 2 210-217 2001/02
  •  Significance of CD30-positive lymphocytes in primary biliary cirrhosis J Gastroenterol Hepatol 14 12 1197-1202 1997/12
  •  Accumulating CD57 + CD3 + natural killer T cells are related to intrahepatic bile duct lesions in primary biliary cirrhosis. LIVER 23 2 94-100 2003/04
  •  Osteopontin is involved in the formation of epithelioid granuloma and bile duct injury in primary biliary cirrhosis. PATHOLOGY INTERNATIONAL 35 1 8-17 2003/01
  •  Lipopolysaccharide activates nuclear factor-kappaB through toll-like receptors and related molecules in cultured biliary epithelial cells. LABORATORY INVESTIGATION 83 11 1657-1667 2003/11
  •  Reduced expression of syndecan-1 correlates with histologic dedifferentiation, lymph node metastasis, and poor prognosis in intrahepatic cholangiocarcinoma. HUMAN PATHOLOGY 34 9 857-863 2003/09
  •  Type1 and type2 memory T cells imbalance shown by expression of intrahepatic chemokine receptors relates to pathogenesis of primary biliary cirrhosis. 24 3 290-299 2002/11
  •  Th1 cytokine-induced downregulation of PPARgamma in human biliary cells relates to cholangitis in primary biliary cirrhosis. HEPATOLOGY 41 6 1329-1338 2005/06
  •  Peptide Antibiotic Human Beta-Defensin-1 and -2 Constitute Antimicrobial Defense in the Intrahepatic Biliary Tree HEPATOLOGY 40 4 925-932 2004/10
  •  Innate immune response to double-stranded RNA in biliary epithelial cells is associated with the pathogenesis of biliary atresia. HEPATOLOGY 27;46(4) 1146-1154 2007/07
  •  Induction of innate immune response and absence of subsequent tolerance to dsRNA in biliary epithelial cells relate to the pathogenesis of biliary atresia. Liver Int 28(5) 614-21 2008/05
  •  Epithelial-mesenchymal transition induced by biliary innate immunity contributes to the sclerosing cholangiopathy of biliary atresia. J Pathol. 217(5) 654-64 2009
  •  Periductal interleukin-17 production in association with biliary innate immunity contributes to the pathogenesis of cholangiopathy in primary biliary cirrhosis. Clin Exp Immunol. 157(2):261-70 2009/08
  •  Unclassified hepatocellular adenoma in a middle-aged woman with glucose intolerance. Ozaki K, Harada K, Yamamoto T, Aoyagi H, Kaizaki Y, Yoshikawa J.  Clin J Gastroenterol.  2017
  •  Usefulness of laparoscopy and intraductal ultrasonography in a patient with isolated immunoglobulin G4-related sclerosing cholangitis.  Ohno Y, Kumagi T, Imamura Y, Kuroda T, Koizumi M, Watanabe T, Yoshida O, Tokumoto Y, Takeshita E, Abe M, Harada K, Hiasa Y.  Clin J Gastroenterol.  2017
  •  Role for Neutrophil Extracellular Traps (NETs) and Platelet Aggregation in Early Sepsis-induced Hepatic Dysfunction.  Sakurai K, Miyashita T, Okazaki M, Yamaguchi T, Ohbatake Y, Nakanuma S, Okamoto K,Sakai S, Kinoshita J, Makino I, Nakamura K, Hayashi H, Oyama K, Tajima H, Takamura H, Ninomiya I, Fushida S, Harada K, Harmon JW, Ohta T. In Vivo.  31 6 1051-1058. 2017
  •  BRAF V600E, TERT promoter mutations and CDKN2A/B homozygous deletions are frequent in epithelioid glioblastomas: A histological and molecular analysis focusing on intratumoral heterogeneity.  Nakajima N, Nobusawa S, Nakata S, Nakada M, Yamazaki T, Matsumura N, Harada K, Matsuda H, Funata N, Nagai S, Nakamura H, Sasaki A, Akimoto J, Hirato J, Yokoo H.  Brain Pathol.  2017
  •  Clinicopathological Study of Autoimmune Hepatitis Cases That Were Difficult to Differentiate from Drug-Induced Liver Injury. Tsutsui A, Harada K, Tsuneyama K, Senoh T, Nagano T, Takaguchi K, Ando M, Nakamura S, Mizobuchi K, Kudo M. Dig Dis. 35 6 506-514. 2017
  •  Sclerosing and obstructive cholangiopathy in biliary atresia: mechanisms and association with biliary innate immunity Kenichi Harada Pediatr Surg Int 2017
  •  Clinical features of cystatin A expression in patients with pancreatic ductal adenocarcinoma. Komura T, Takabatake H, Harada K, Yamato M, Miyazawa M, Yoshida K, Honda M, Wada T, Kitagawa H, Ohta T, Kaneko S, Sakai Y. Cancer Sci. 2017
  •  A case of ruptured hepatocellular carcinoma (HCC) in resolving non-alcoholic steatohepatitis associated with type 2 diabetes: Is early detection of diabetes-related HCC feasible? Ikura Y, Tiniakos DG, Tanaka T, Harada K. J Diabetes. 9 3 311-313. 2017
  •  Gadoxetic acid-enhanced magnetic resonance imaging reflects co-activation of β-catenin and hepatocyte nuclear factor 4α in hepatocellular carcinoma. Kitao A, Matsui O, Yoneda N, Kozaka K, Kobayashi S, Koda W, Minami T, Inoue D, Yoshida K, Yamashita T, Yamashita T, Kaneko S, Takamura H, Ohta T, Ikeda H, Sato Y, Nakanuma Y, Harada K, Kita R, Gabata T.  Hepatol Res. 2017
  •  Diagnostic sensitivity of cutoff values of IgG4-positive plasma cell number and IgG4-positive/CD138-positive cell ratio in typical multiple lesions of patients with IgG4-related disease. Mizushima I, Yamada K, Harada K, Matsui S, Saeki T, Kondo S, Takahira M, Waseda Y, Hamaguchi Y, Fujii H, Yamagishi M, Kawano M. Mod Rheumatol. 22 1-7 2017
  •  Challenges and difficulties in pathological diagnosis of autoimmune hepatitis. Harada K, Hiep NC, Ohira H. Hepatol Res.  47 10 963-971 2017
  •  Safety, Tolerability, and Preliminary Efficacy of the Anti-Fibrotic Small Molecule PRI-724, a CBP/β-Catenin Inhibitor, in Patients with Hepatitis C Virus-related Cirrhosis: A Single-Center, Open-Label, Dose Escalation Phase 1 Trial Kimura K, Ikoma A, Shibakawa M, Shimoda S, Harada K, Saio M, Imamura J, Osawa Y, Kimura M, Nishikawa K, Okusaka T, Morita S, Inoue K, Kanto T, Todaka K, Nakanishi Y, Kohara M, Mizokami M. E Bio Medicine 2017
  •  The simultaneous inhibition of the mTOR and MAPK pathways with Gnetin-C induces apoptosis in acute myeloid leukemia Espinoza JL, Elbadry MI , Taniwaki M , Harada K ,Trung LQ , Nakagawa N , Takami A , Ishiyama K ,Yamauchi T, Takenaka K , Nakao S. Cancer Letters 400 127-136 2017
  •  Acute presentation of autoimmune hepatitis: a multicentre study with detailed histological evaluation in a large cohort of patients. Hiep NC, Harada K, Ouchi H, Sato Y,Tsuneyama , Kage M, Nakano M, Yoshizawa K, Takahashi A, Abe , Kang JH, Koike K, Inui A, Fujisawa T, Takaki A, Arinaga-Hino T, Torimura T, Suzuki Y, Fujiwara K, Zeniya Ohira H, Tanaka A, Takikawa H; Intractable Liver and Biliary Diseases Study Group of Japan. J Clin Pathol. 2017
  •  Rathke Cleft Cyst with Entirely Ossified Cyst Wall and Partially Solid Cyst Content: A Case Report and Literature Review Hayashi Y, Oishi M, Fukui I, Sasagawa Y, Harada K, Nakada M. World Neurosurg.  2017 Feb;98:882.e15-882.e20.  2017
  •  The PD-1/PD-L1 axis may be aberrantly activated in occupational cholangiocarcinoma Sato Y, Masahiko Kinoshita M, Takemura S, Tanaka S, Hamano G, Nakamori S, Fujikawa M, Sugawara Y, Yamamoto T, Arimoto A, Yamamura M, Sasaki M, Harada K, Nakanuma Y and Kubo S.  Pathol Int. 67 3 163-170 2017
  •  Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal paucity of alterations in TP53 and SMAD4. Hosoda W, Chianchiano P, Griffin JF, Pittman ME, Brosens LA, Noë M, Yu J, Shindo K, Suenaga M, Rezaee N, Yonescu R, Ning Y, Albores-Saavedra J, Yoshizawa N, Harada K, Yoshizawa A, Hanada K, Yonehara S, Shimizu M, Uehara T, Samra JS, Gill AJ, Wolfgang CL, Goggins MG, Hruban RH, Wood LD. J Pathol. 242 1 16-23 2017
  •  Expression and localization of sterile alpha motif domain containing 5 is associated with cell type and malignancy of biliary tree. Yagai T, Matsui S, Harada K, Inagaki F, Saijou E, Miura Y, Nakanuma Y, Miyajima A, Tanaka M.  PLoS One. 12 4 e0175355. 2017
  •  Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for primary biliary cholangitis in the Japanese population. Kawashima M, Hitomi Y, Aiba Y, Nishida N, Kojima K, Kawai Y, Nakamura H, Tanaka A,Zeniya M, Hashimoto E, Ohira H, Yamamoto K, Abe M, Nakao K, Yamagiwa S, Kaneko S, Honda M, Umemura T, Ichida T, Seike M, Sakisaka S, Harada M, Yokosuka O, Ueno Y, Senju M, Kanda T, Shibata H, Himoto T, Murata K, Miyake Y, Ebinuma H, Taniai M, Joshita S, Nikami T, Ota H, Kouno H, Kouno H, Nakamuta M, Fukushima N, Kohjima M,Komatsu T, Komeda T, Ohara Y, Muro T, Yamashita T, Yoshizawa K, Nakamura Y, Shimada M, Hirashima N, Sugi K, Ario K, Takesaki E, Naganuma A, Mano H, Yamashita H, Matsushita K, Yamauchi K, Makita F, Nishimura H, Furuta K, Takahashi N, Kikuchi M, Masaki N, Tanaka T, Tamura S, Mori A, Yagi S, Shirabe K, Komori A, Migita K, Ito M, Nagaoka S, Abiru S, Yatsuhashi H, Yasunami M, Shimoda S, Harada K, Egawa H, Maehara Y, Uemoto S, Kokudo N, Takikawa H, Ishibashi H, Chayama K, Mizokami M, Nagasaki M, Tokunaga K, Nakamura M.  Hum Mol Genet. 26 3 650-659 2017
  •  Pathological findings of nonalcoholic steatohepatitis and nonalcoholic fatty liver disease. Sakamoto M, Tsujikawa H, Effendi K, Ojima H, Harada K, Zen Y, Kondo F, Nakano M, Kage M, Sumida Y, Hashimoto E, Yamada G, Okanoue T, Koike K.  Pathol Int. 67 1 1-7 2017
  •  正常肝に発生した細胆管細胞癌の1例 49 10 1006-1015 2016
  •  Adult bile duct strictures: differentiating benign biliary stenosis from cholangiocarcinoma Nguyen Canh Hiep, Kenichi Harada. Medical Molecular Morphology 2016
  •  Hepatocyte nuclear factor 1α-inactivated hepatocellular adenomas exhibit high 18F-fludeoxyglucose uptake associated with glucose-6-phosphate transporter inactivation Kumi Ozaki, Kenichi Harada, Noboru Terayama, Osamu Matsui, Satoshi Saitoh, Yoshito Tomimaru, Takeshi fujii, Toshifumi Gabata. Br J Radiol 2016
  •  Characterization of intraductal papillary neoplasm of bile duct with respect to histopathologic similarities to pancreatic intraductal papillary mucinous neoplasm. Nakanuma Y, Kakuda Y, Uesaka K, Miyata T, Yamamoto Y, Fukumura Y, Sato Y, Sasaki M, Harada K, Takase M. Hum Pathol. 51 103-13 2016
  •  Application and Validation of a New Histologic Staging and Grading System for Primary Biliary Cirrhosis. Harada K, Hsu M, Ikeda H, Zeniya M, Nakanuma Y. J Clin Gastroenterol 47 2 174-81 2013
  •  Participation of natural killer cells in the pathogenesis of bile duct lesions in biliary atresia Okamura, Atsushi; Harada, Kenichi; Nio, Masaki; Nakanuma, Yasuni Journal of Clinical Pathology 66 2 99-108 2013 
  •  Tissue culture correlational study of genetic cholangiopathy of autosomal recessive polycystic kidney disease Nakanuma, Yasuni; Sato, Yasunori; Harada, Kenichi Methods in Molecular Biology 945 303-318 2013 
  •  Clinicopathological significance of S100 protein expression in cholangiocarcinoma Sato, Yasunori; Harada, Kenichi; Sasaki, Motoko; Nakanuma, Yasuni Journal of Gastroenterology and Hepatology (Australia) 28 8 1422-1429 2013 
  •  Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis. Harada K, Kakuda Y, Sato Y, Ikeda H, Shimoda S, Yamamoto Y, Inoue H, Ohta H,  J Clin Pathol 2013
  •  Clinicopathological significance of serum fractalkine in primary biliary cirrhosis. Harada K, Kakuda Y, Nakamura M, Shimoda S, Nakanuma Y. Dig Dis Sci 58 10 3037-43 2013
  •  Histological characteristics of biliary intraepithelial neoplasia-3 and intraepithelial spread of cholangiocarcinoma. Sato Y, Harada K, Sasaki M, Nakanuma Y.  Virchows Arch 462 4 421-7 2013
  •  Biliary adenofibroma with ominous features of imminent malignant changes  Akemi Tsutsui, Yoshimi Bando, Yasunori Sato, Hidenori Miyake, Seiko Sawada-Kitamura,  Clin J Gastroenterol.  2014
  •  What Are the Precursor and Early Lesions of Peripheral Intrahepatic Cholangiocarcinoma? Yasuni Nakanuma, Akemi Tsutsui, Xiang Shan Ren, Kenichi Harada,  International Journal of Hepatology. 2014
  •  Extrahepatic Malignancies in Primary Biliary Cirrhosis: A Comparative Study at Two Europian Centers.  Floreani A, Spinazze A, Caballeria L, Reig A, Cazzagon N, Franceschet I, Buja A, Furlan P, Clin Rev Allergy Immunol.  2014
  •  Histological characterization of biliary intraepithelial neoplasia with respect to pancreatic intraepithelial neoplasia. Yasunori Sato, Kenichi Harada, Motoko Sasaki, Yasuni Nakanuma. International Journal of Hepatology. 2014
  •  Systemic and local expression levels of TNF-like ligand 1A and its decoy receptor 3 are increased in primary biliary cirrhosis Yoshihiro Aiba, Kenichi Harada, Atsumasa Komori, Masahiro Ito, Shinji Shimoda,  Liver International 34 679-688 2014
  •  Different carcinogenic process in cholangiocarcinoma cases epidemically developing among workers of a printing company in Japan Yasunori Sato, Shoji Kubo, Shigekazu Takemura, Yasuhiko Sugawara, Shogo Tanaka, Int J Clin Exp Pathol. 7 8 4745-4754 2014
  •  Clinical course after corticosteroid therapy in IgG4-related aortitis/periaortitis and periarteritis: a retrospective multicenter study  Ichiro Mizushima, Dai Inoue, Motohisa Yamamoto, Kazunori Yamada, Takako Saeki, Arthritis Research & Therapy  16 4 R156 2014
  •  Cholangiocarcinoma with respect to IgG4 Reaction : Review Article Kenichi Harada, Yasuni Nakanuma. International Journal of Hepatology 2014
  •  Significance of oestrogen-related receptor γon biliary epithelial cells in the pathogenesis of primary biliary cirrhosis. Kenichi Harada, Kakuda Yuko, Yasunori Sato, Hiroko ikeda, Yasuni Nakanuma. J Clin Pathol. 67 566-572 2014
  •  Clinicopathological study of primary biliary cirrhosis with interface hepatitis compared to autoimmune hepatitis. Mio Kobayashi, Yuko Kakuda, Kenichi Harada, Yasunori Sato, Motoko Sasaki,  World J Gastroenterol.  20 13 3597-3608 2014
  •  A condition closely mimicking IgG4-related disease despite the absence of serum IgG4 elevation and IgG4-positive plasma cell infiltration. Satoshi Hara, Mitsuhiro Kawano, Ichiro mizushima, Kazunori Yamada, Kentaro Fujita,  MODERN RHEUMATOLOGY.  2 1-6 2014
  •  Prevalence and risk factors of hepatocellular carcinoma in Japanese patients with primary biliary cirrhosis. Harada K, Nakanuma Y.  Hepatol Res  44 2 133-40 2014
  •  Activation of the PI3K/mTOR Pathway Is Involved in Cystic Proliferation of Cholangiocytes of the PCK Rat. Ren XS, Sato Y, Harada K, Sasaki M, Furubo S, Song JY, Nakanuma Y. PLoS One 30 9(1) e87660. 2014
  •  Cystic and micropapillary epithelial changes of peribiliary glands might represent a precursor lesion of biliary epithelial neoplasms. Sato Y, Harada K, Sasaki M, Nakanuma Y. Virchows Arch. 464 2 157-63 2014
  •  Guidelines for the management of primary biliary cirrhosis: The Intractable Hepatobiliary Disease Study Group supported by the Ministry of Health, Labour and Welfare of Japan.  Working Subgroup (English version) for Clinical Practice Guidelines for Primary Biliary  Hepatol Res. S1 71-90 2014
  •  Proposal of a new disease concept "biliary diseases with pancreatic counterparts". Anatomical and pathological bases. Nakanuma Y, Harada K, Sasaki M, Sato Y. Histol Histopathol 29 1 1-10 2014
  •  Multicentric Castleman Disease With Tubulointerstitial Nephritis Mimicking IgG4-related Disease: Two Case Reports. Zoshima T, Yamada K, Hara S, Mizushima I, Yamagishi M, Harada K, Sato Y, Kawano M. Am J Surg Pathol. 40 4 495-501 2016/04
  •  IgG4-related stomach muscle lesion with a renal pseudotumor and multiple renal rim-like lesions: A rare manifestation of IgG4-related disease.  Inoue K, Okubo T, Kato T, Shimamura K, Sugita T, Kubota M, Kanaya K,Yamachika D,  Mod Rheumatol. 18 1-5 2015/09
  •  Natural killer cells regulate T cell immune responses in primary biliary cirrhosis.  Shimoda S, Hisamoto S, Harada K, Iwasaka S, Chong Y, Nakamura M, Bekki Hepatology. 2015/08
  •  Altered intrahepatic microcirculation of idiopathic portal hypertension in relation to glutamine synthetase expression  Sato Y, Harada K, Sasaki M, Nakanuma Y. Hepatol Res 2015
  •  Autoantibody status and histological variables influence biochemical rewsponse to treatment and long-term outcomes in Japanese patients with primary biliary cirrhosis  Nakamura M, Kondo H, Tanaka A, Komori A , Ito M, Yamamoto k, Ohira H,Zeniya M,  Hepatol Res. 45 846-855 2015
  •  Inflammatory Features of Pancreatic Cancer Highlighted byMonocytes/Macrophages and CD4+ T cells with Clinical Impact. Komura T, Sakai Y, Harada K, Kawaguchi K, Takabatake H, Kitagawa H, Wada T,  Cancer Sci. 106 6 672-86 2015/06
  •  A variant of multicystic biliary hamartoma presenting as an intrahepatic cystic neoplasm. Tominaga T, Abo T, Kinoshita N, Murakami T, Sato Y, Nakanuma Y, Harada K,  Clin J Gastroenterol. 2015/05
  •  Autophagy and senescence in fibrosing cholangiopathies Nakanuma Y, Sasaki M, Harada K. Journal of Hepatology 62 934-945 2015
  •  Growth arrest and DNA damage-inducible 34 regulates liver regeneration in hepatic steatosis in mice. Inaba Y, Furutani T, Kimura K, Watanabe H, Haga S, Kido Y, Matsumoto M, Yamamoto Y,  Hepatology. 2015 61(4) 1343-56 2015/04

Conference Presentations

  • Mechanisms of the sclerosing and obstructive cholangiopathy in biliary atresia: Association with biliary innate immunity. (conference:ISSBA シンポジウム2 Etiology and Pathophysiology)(2017/05/12)
  • The essence of the bile ductular carcinoma from the viewpoint of surgeon(2017/07/06)
  • CT findings of cholangiolocellular carcinoma in comparison with those of HCC and CCC(2017/07/06)
  • Imatinib Induces Apoptosis of NK/T Cell Neoplasms by Inhibitiong Hematopoietic Cell Kinase and NQO2 (conference:ASH (AMERICAN SOCIETY OF HEMATOLOGY)59th Annual meeting 2017)(2017/12/09)
  • Increased expression and altered localization of cathepsis Z is associated with progression to jaundice-stage in primary biliary cholangitis (conference:AASLD The Liver Meeting 2017)(2017/10/20)

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  • A cute presentation ofo autoimmune hepatitis in adults and children: histological Spectrum and features distinguishing it from drug-induced liver injury and acute Viral hepatitis.(2017/10/20)
  • Immune-mediated cystatin A expression in patients with pancreatic Ductal adenocarcinoma(conference:ESMO Immuno Oncology Congress 2017)(2017/12/07)
  • Pathology Update 「Recent Pathological Concept of Pancreaticobiliary Diseases」(conference:第74回日本医学放射線学会総会「Pathology Update 胆・膵」)(2015/04/18)
  • Cholangiocarcinoma with respect IgG4 Reaction(conference:IAP)(2014/10/05)
  • IgG4 reaction in biliary intraepithelial neoplasia and cholangiocarcinoma arising from sclerosing cholangitis(conference:The 102nd USCAP ANNUAL MEETING)(2013/03/02)
  • Energy metabolic change induced by ERRα-PGC-1α axis in chronic non-suppurative destructive cholangitis of primary biliary cirrhosis(conference:The 102nd USCAP ANNUAL MEETING)(2013/03/02)
  • Pathological Differences between IgG4-Related Sclerosing Cholangitis with and without Autoimmune Pancreatitis(conference:The 102nd USCAP ANNUAL MEETING )(2013/03/02)
  • Alteration of energy metabolism and subsequent oxidative stress in the pathogenesis of cholangiopathy in primary biliary cirrhosis (conference:The Liver Meeting 2013)(2013/11/01)
  • Clinicopathological significance of serum fractalkine and its regulation by ursodeoxycholic acid in primary biliary cirrhosis (conference:The Liver Meeting 2013 )(2013/11/01)

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「難治性の肝・胆道疾患に関する調査研究」(2017-2019) 
○「肝内胆管癌の遺伝子・分子生物学的機構に基づいたイメージバイオマーカーの研究」(2016-2018) 
○「小児期発症の希少難治性肝胆膵疾患における包括的な診断・治療ガイドライン作成に関する研究」(2014-2015) 
○「C型肝炎ウイルスに起因する肝硬変に対する抗線維化治療薬の開発に関する研究」(2013-2015) 
○「胆道閉鎖症の病態解明-胆道系自然免疫から獲得免疫への連携と自己免疫現象の解析」(2008-2010) 
○「原発性胆汁性肝硬変の胆管細胞アポトーシスにおける自然免疫の関与」(2007-2007) 
○「原発性胆汁性肝硬変の胆管細胞アポトーシスにおける自然免疫の関与」(2007-2007) 
○「原発性胆汁性肝硬変の胆管細胞アポトーシスにおける自然免疫の関与」(2006-2006) 
○「原発性胆汁性肝硬変の肝内胆管細胞培養株の樹立と病態解析への応用」(2005-2005) 
○「原発性胆汁性肝硬変の肝内胆管細胞培養株の樹立と病態解析への応用」(2004-2004) 
○「原発性胆汁性肝硬変における肝内胆管破壊の分子機構」(2003-2003) 
○「原発性胆汁性肝硬変における肝内胆管破壊の分子機構」(2002-2002) 
○「原発性胆汁性肝硬変の肝組織内における疾患特異的抗原成分の検出の試み」(1998-1998) 
○「原発性胆汁性肝硬変の肝組織内における疾患特異的抗原成分の検出の試み」(1997-1998) 
○「原発性胆汁性肝硬変の胆管病変におけるエネルギー代謝の解析と治療戦略」(2014-2016) 
○「原発性胆汁性肝硬変の胆管病変における性ホルモンの関与と治療戦略」(2011-2013) 
○「胆道閉鎖症の病態解明-胆道系自然免疫から獲得免疫への連携と自己免疫現象の解析」(2009-2010) 
○「包括的1細胞遺伝子解析法を用いた自己免疫性肝疾患の病理学的解析」(2017-2019) 
○「肝細胞癌の分子・遺伝子的亜分類に基づいたradiogenomics」(2017-2019) 
○「原発性胆汁性胆管炎模倣培養系からのゲノム・脂質情報を利用した新規治療法の開発」(2017-2019) 

Classes (Bachelors)

○Freshman Seminar I(2018)
○Human Pathology(2017)
○Freshman Seminar I(2017)
○Basic Health Science(2017)
○Human Pathology(2016)
○Human Pathology(2016)
○Freshman Seminar I(2016)
○Basic Health Science(2016)

Classes (Graduate Schools)

○Medical Sciences(2017)
○Pathology and Pathogenesis(2017)
○Morpho-Functional Pathology(2017)
○Morpho-Functional Pathology(2017)
○Morpho-Functional Pathology(2017)
○Introduction to Basic Medical Science(2016)
○Pathology and Pathogenesis(2016)
○Morpho-Functional Pathology(2016)
○Morpho-Functional Pathology(2016)
○Morpho-Functional Pathology(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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