last modified：2026/04/29
Professor HOSHII Takayuki
Faculty, Affiliation
Cancer Research Institute Division of Transcriptional Control and Engineering, Cancer Research Institute
College and School Educational Field
Laboratory
Division of Transcriptional Control and Engineering TEL:076-264-6720 FAX:076-234-4525
Academic Background
Career
Kanazawa University Division of Transcriptional Control and Engineering, Cancer Research Institute Professor(2026/04-)
Chiba University Department of Molecular Oncology, Graduate School of Medicine Associate Professor(2024/02-2026/03)
Chiba University Department of Molecular Oncology, Graduate School of Medicine(2020/01-2024/01)
Chiba University Department of Molecular Oncology, Graduate School of Medicine(2019/02-2019/12)
Dana-Farber Cancer Institute Department of Pediatric Oncology Scientist I(2016/07-2019/01)
Memorial Sloan Kettering Cancer Center Center for Epigenetics Research Research Fellow(2014/04-2016/06)
Cancer Research Institute Kanazawa University Division of Molecular Genetics Assistant Professor(2010/04-2014/03)
Cancer Research Institute Kanazawa University Division of Molecular Genetics(2007/04-2010/03)
Year & Month of Birth
1980/01
Academic Society
Award
Specialities
Molecular biology、Hematology、Tumor biology、Genome biology、Cell biology
Speciality Keywords
genome editing,Leukemia,epigenetics
Research Themes
Books
Papers
- A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response. Takayuki Hoshii,Paolo Cifani,Zhaohui Feng,Chun-Hao Huang,Richard Koche,Chun-Wei Chen,Christopher D Delaney,Scott W Lowe,Alex Kentsis,Scott A Armstrong Cell 172 5 1007 2018/02/22
- ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia. Liling Wan,Hong Wen,Yuanyuan Li,Jie Lyu,Yuanxin Xi,Takayuki Hoshii,Julia K Joseph,Xiaolu Wang,Yong-Hwee E Loh,Michael A Erb,Amanda L Souza,James E Bradner,Li Shen,Wei Li,Haitao Li,C David Allis,Scott A Armstrong,Xiaobing Shi Nature 543 7644 265 2017/03/09
- Regulation of H3K4me3 breadth and MYC expression by the SETD1B catalytic domain in MLL-rearranged leukemia. Shintaro Izumi,Ko Ohtani,Makoto Matsumoto,Seito Shibata,Bahityar Rahmutulla,Masaki Fukuyo,Mitsutaka Nishimoto,Hideo Miyagawa,Emiko Sakaida,Koutaro Yokote,Issay Kitabayashi,Kimi Araki,Atsushi Kaneda,Takayuki Hoshii Leukemia 39 7 1627 2025/07
- BOD1L mediates chromatin binding and non-canonical function of H3K4 methyltransferase SETD1A. Takayuki Hoshii,Sota Kikuchi,Tomoya Kujirai,Takeshi Masuda,Tomoko Ito,Satoshi Yasuda,Makoto Matsumoto,Bahityar Rahmutulla,Masaki Fukuyo,Takeshi Murata,Hitoshi Kurumizaka,Atsushi Kaneda Nucleic acids research 2024/07/11
- SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia Hoshii, T,Perlee, S,Kikuchi, S,Rahmutulla, B,Fukuyo, M,Masuda, T,Ohtsuki, S,Soga, T,Nabet, B,Kaneda, A Cell Rep. 41 9 111727 2022/11/29
- Strong therapeutic potential of γ-secretase inhibitor MRK003 for CD44-high and CD133-low glioblastoma initiating cells. Shingo Tanaka,Mitsutoshi Nakada,Daisuke Yamada,Ichiro Nakano,Tomoki Todo,Yasushi Ino,Takayuki Hoshii,Yuko Tadokoro,Kumiko Ohta,Mohamed A E Ali,Yutaka Hayashi,Jun-ichiro Hamada,Atsushi Hirao Journal of neuro-oncology 121 2 239 2015/01
- mTORC1 Inactivation Prevents and Eradicates Acute Lymphoblastic T-Cell Leukemia Takayuki Hoshii,Atsuo Kasada,Tomoki Hatakeyama,Masashi Ohtani,Yuko Tadokoro,Kazuhito Naka,Tsuneo Ikenoue,Tomokatsu Ikawa,Hiroshi Kawamoto,Kimi Araki,Ken-ichi Yamamura,Atsushi Iwama,Satoshi Matsuda,Atsushi Hirao BLOOD 122 21 2013/11
- NKX2.2 suppresses self-renewal of glioma-initiating cells. Teruyuki Muraguchi,Shingo Tanaka,Daisuke Yamada,Akira Tamase,Mitsutoshi Nakada,Hideo Nakamura,Takayuki Hoshii,Takako Ooshio,Yuko Tadokoro,Kazuhito Naka,Yasushi Ino,Tomoki Todo,Jun-ichi Kuratsu,Hideyuki Saya,Jun-ichiro Hamada,Atsushi Hirao Cancer research 71 3 1135 2011/02/01
- Mechanistic / mammalian target protein of rapamycin signaling in hematopoietic stem cells and leukemia. Atsushi Hirao,Takayuki Hoshii Cancer science 104 8 977 2013/08
- Molecular pathology of tumor-initiating cells: lessons from Philadelphia chromosome-positive leukemia. Kazuhito Naka,Takayuki Hoshii,Yuko Tadokoro,Atsushi Hirao Pathology international 61 9 501 2011/09
- Novel therapeutic approach to eradicate tyrosine kinase inhibitor resistant chronic myeloid leukemia stem cells. Kazuhito Naka,Takayuki Hoshii,Atsushi Hirao Cancer science 101 7 1577 2010/07
- Methyl-beta-cyclodextrin improves fertilizing ability of C57BL/6 mouse sperm after freezing and thawing by facilitating cholesterol efflux from the cells. Toru Takeo,Takayuki Hoshii,Yuki Kondo,Hiroshi Toyodome,Hidetoshi Arima,Ken-ichi Yamamura,Tetsumi Irie,Naomi Nakagata Biology of reproduction 78 3 546 2008/03
- Metabolic regulation of osteoclast differentiation and function. Yoriko Indo,Sunao Takeshita,Kiyo-Aki Ishii,Takayuki Hoshii,Hiroyuki Aburatani,Atsushi Hirao,Kyoji Ikeda Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 28 11 2392 2013/11
- Identification of stem cells during prepubertal spermatogenesis via monitoring of nucleostemin promoter activity. Masako Ohmura,Kazuhito Naka,Takayuki Hoshii,Teruyuki Muraguchi,Haruhiko Shugo,Akira Tamase,Noriyuki Uema,Takako Ooshio,Fumio Arai,Keiyo Takubo,Go Nagamatsu,Isao Hamaguchi,Minoru Takagi,Masahiko Ishihara,Kazuhiro Sakurada,Hiromasa Miyaji,Toshio Suda,Atsushi Hirao Stem cells (Dayton, Ohio) 26 12 3237 2008/12
- mTORC1 is essential for leukemia propagation but not stem cell self-renewal. Takayuki Hoshii,Yuko Tadokoro,Kazuhito Naka,Takako Ooshio,Teruyuki Muraguchi,Naoyuki Sugiyama,Tomoyoshi Soga,Kimi Araki,Ken-Ichi Yamamura,Atsushi Hirao The Journal of clinical investigation 122 6 2114 2012/06
- Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Yoshinobu Ichimura,Satoshi Waguri,Yu-Shin Sou,Shun Kageyama,Jun Hasegawa,Ryosuke Ishimura,Tetsuya Saito,Yinjie Yang,Tsuguka Kouno,Toshiaki Fukutomi,Takayuki Hoshii,Atsushi Hirao,Kenji Takagi,Tsunehiro Mizushima,Hozumi Motohashi,Myung-Shik Lee,Tamotsu Yoshimori,Keiji Tanaka,Masayuki Yamamoto,Masaaki Komatsu Molecular cell 51 5 618 2013/09/12
- Abundant nucleostemin expression supports the undifferentiated properties of germ cell tumors. Noriyuki Uema,Takako Ooshio,Kenichi Harada,Masako Naito,Kazuhito Naka,Takayuki Hoshii,Yuko Tadokoro,Kumiko Ohta,Mohamed A E Ali,Miyuki Katano,Tomoyoshi Soga,Yasuni Nakanuma,Akihiko Okuda,Atsushi Hirao The American journal of pathology 183 2 592 2013/08
- Nucleostemin in injury-induced liver regeneration. Haruhiko Shugo,Takako Ooshio,Masako Naito,Kazuhito Naka,Takayuki Hoshii,Yuko Tadokoro,Teruyuki Muraguchi,Akira Tamase,Noriyuki Uema,Taro Yamashita,Yasunari Nakamoto,Toshio Suda,Shuichi Kaneko,Atsushi Hirao Stem cells and development 21 16 3044 2012/11/01
- Cutting edge: mTORC1 in intestinal CD11c+ CD11b+ dendritic cells regulates intestinal homeostasis by promoting IL-10 production. Masashi Ohtani,Takayuki Hoshii,Hideki Fujii,Shigeo Koyasu,Atsushi Hirao,Satoshi Matsuda Journal of immunology (Baltimore, Md. : 1950) 188 10 4736 2012/05/15
- TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia. Kazuhito Naka,Takayuki Hoshii,Teruyuki Muraguchi,Yuko Tadokoro,Takako Ooshio,Yukio Kondo,Shinji Nakao,Noboru Motoyama,Atsushi Hirao Nature 463 7281 676 2010/02/04
- Defective development of the gall bladder and cystic duct in Lgr4- hypomorphic mice. Ryo Yamashita,Yumiko Takegawa,Machiko Sakumoto,Mai Nakahara,Haruna Kawazu,Takayuki Hoshii,Kimi Araki,Yuji Yokouchi,Ken-ichi Yamamura Developmental dynamics : an official publication of the American Association of Anatomists 238 4 993 2009/04
- Regulation of reactive oxygen species and genomic stability in hematopoietic stem cells. Kazuhito Naka,Teruyuki Muraguchi,Takayuki Hoshii,Atsushi Hirao Antioxidants & redox signaling 10 11 1883 2008/11
- Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin. Akira Tamase,Teruyuki Muraguchi,Kazuhito Naka,Shingo Tanaka,Masashi Kinoshita,Takayuki Hoshii,Masako Ohmura,Haruhiko Shugo,Takako Ooshio,Mitsutoshi Nakada,Kazunobu Sawamoto,Masafumi Onodera,Kunio Matsumoto,Masanobu Oshima,Masahide Asano,Hideyuki Saya,Hideyuki Okano,Toshio Suda,Jun-ichiro Hamada,Atsushi Hirao Proceedings of the National Academy of Sciences of the United States of America 106 40 17163 2009/10/06
- Identification of stem cells during prepubertal spermatogenesis via monitoring of nucleostemin promoter activity. Ohmura M,Naka K,Hoshii T,Muraguchi T,Shugo H,ISHIHARA MASAHIKO Stem Cells 26 12 3237 2008
- The molecular bases of the self-renewal and differentiation of leukemic stem cells Kazuhito Naka,Masako Ohmura,Takayuki Hoshii,Teruyuki Muraguchi,Atsushi Hirao Current Cancer Therapy Reviews 4 3 178 2008
- Pleiotropic roles of mTOR complexes in haemato-lymphopoiesis and leukemogenesis. Takayuki Hoshii,Satoshi Matsuda,Atsushi Hirao Journal of biochemistry 156 2 73 2014/08
- LGR4 regulates the postnatal development and integrity of male reproductive tracts in mice. Takayuki Hoshii,Toru Takeo,Naomi Nakagata,Motohiro Takeya,Kimi Araki,Ken-ichi Yamamura Biology of reproduction 76 2 303 2007/02
- The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells. Kazuhito Naka,Ryosuke Ochiai,Eriko Matsubara,Chie Kondo,Kyung-Min Yang,Takayuki Hoshii,Masatake Araki,Kimi Araki,Yusuke Sotomaru,Ko Sasaki,Kinuko Mitani,Dong-Wook Kim,Akira Ooshima,Seong-Jin Kim Nature communications 11 1 4681 2020/09/17
- Loss of Tsc1 accelerates malignant gliomagenesis when combined with oncogenic signals. Daisuke Yamada,Takayuki Hoshii,Shingo Tanaka,Ahmed M Hegazy,Masahiko Kobayashi,Yuko Tadokoro,Kumiko Ohta,Masaya Ueno,Mohamed A E Ali,Atsushi Hirao Journal of biochemistry 155 4 227 2014/04
- Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress. Yuko Tadokoro,Takayuki Hoshii,Satoshi Yamazaki,Koji Eto,Hideo Ema,Masahiko Kobayashi,Masaya Ueno,Kumiko Ohta,Yuriko Arai,Eiji Hara,Kenichi Harada,Masanobu Oshima,Hiroko Oshima,Fumio Arai,Akihiko Yoshimura,Hiromitsu Nakauchi,Atsushi Hirao Cell stem cell 22 5 713 2018/05/03
- PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORγ. Yutaka Kurebayashi,Shigenori Nagai,Ai Ikejiri,Masashi Ohtani,Kenji Ichiyama,Yukiko Baba,Taketo Yamada,Shohei Egami,Takayuki Hoshii,Atsushi Hirao,Satoshi Matsuda,Shigeo Koyasu Cell reports 1 4 360 2012/04/19
- SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3. Sarah Perlee,Sota Kikuchi,Tomoyoshi Nakadai,Takeshi Masuda,Sumio Ohtsuki,Makoto Matsumoto,Bahityar Rahmutulla,Masaki Fukuyo,Paolo Cifani,Alex Kentsis,Robert G Roeder,Atsushi Kaneda,Takayuki Hoshii EMBO reports e57108 2023/08/03
- Canonical and Non-Canonical Functions of Histone H3K4 Methylation Modifiers in Cancer. Takayuki Hoshii Cancer science 116 11 2940 2025/11
- Non-enzymatic SETD1A activity drives breast cancer cell proliferation via cyclin K Kanako Hayashi,Takayuki Hoshii,Meng Ning,Makoto Matsumoto,Shintaro Izumi,Masaki Fukuyo,Bahityar Rahmutulla,Masahiko Tanabe,Atsushi Kaneda Breast Cancer Research 27 1 2025/08/11
- Chromatin activation with H3K36me2 and compartment shift in metastatic castration-resistant prostate cancer Sanji Kanaoka,Atsushi Okabe,Manato Kanesaka,Bahityar Rahmutulla,Masaki Fukuyo,Motoaki Seki,Takayuki Hoshii,Hiroaki Sato,Yusuke Imamura,Shinichi Sakamoto,Tomohiko Ichikawa,Atsushi Kaneda Cancer Letters 588 216815 2024/04
- Functional dissection of hematopoietic stem cell populations with a stemness-monitoring system based on NS-GFP transgene expression. Mohamed A E Ali,Kyoko Fuse,Yuko Tadokoro,Takayuki Hoshii,Masaya Ueno,Masahiko Kobayashi,Naho Nomura,Ha Thi Vu,Hui Peng,Ahmed M Hegazy,Masayoshi Masuko,Hirohito Sone,Fumio Arai,Atsushi Tajima,Atsushi Hirao Scientific reports 7 1 11442 2017/09/12
- Histone Acetyltransferase Activity of MOF Is Required for MLL-AF9 Leukemogenesis. Daria G Valerio,Haiming Xu,Chun-Wei Chen,Takayuki Hoshii,Meghan E Eisold,Christopher Delaney,Monica Cusan,Aniruddha J Deshpande,Chun-Hao Huang,Amaia Lujambio,YuJun George Zheng,Johannes Zuber,Tej K Pandita,Scott W Lowe,Scott A Armstrong Cancer research 77 7 1753 2017/04/01
- Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells. Takayuki Hoshii,Atsuo Kasada,Tomoki Hatakeyama,Masashi Ohtani,Yuko Tadokoro,Kazuhito Naka,Tsuneo Ikenoue,Tomokatsu Ikawa,Hiroshi Kawamoto,Hans Joerg Fehling,Kimi Araki,Ken-ichi Yamamura,Satoshi Matsuda,Atsushi Hirao Proceedings of the National Academy of Sciences of the United States of America 111 10 3805 2014/03/11
- Association of a murine leukaemia stem cell gene signature based on nucleostemin promoter activity with prognosis of acute myeloid leukaemia in patients. Mohamed A E Ali,Kazuhito Naka,Akiyo Yoshida,Kyoko Fuse,Atsuo Kasada,Takayuki Hoshii,Yuko Tadokoro,Masaya Ueno,Kumiko Ohta,Masahiko Kobayashi,Chiaki Takahashi,Atsushi Hirao Biochemical and biophysical research communications 450 1 837 2014/07/18
- [Roles of mTORC1 in acute myeloid leukemia]. Takayuki Hoshii,Atsushi Hirao [Rinsho ketsueki] The Japanese journal of clinical hematology 56 4 359 2015/04
- Mixed-Lineage Leukemia Fusions and Chromatin in Leukemia. Andrei V Krivtsov,Takayuki Hoshii,Scott A Armstrong Cold Spring Harbor perspectives in medicine 7 11 2017/11/01
- Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia. Michael W M Kühn,Evelyn Song,Zhaohui Feng,Amit Sinha,Chun-Wei Chen,Aniruddha J Deshpande,Monica Cusan,Noushin Farnoud,Annalisa Mupo,Carolyn Grove,Richard Koche,James E Bradner,Elisa de Stanchina,George S Vassiliou,Takayuki Hoshii,Scott A Armstrong Cancer discovery 6 10 1166 2016/10
- Cross-species chromatin interactions drive transcriptional rewiring in Epstein-Barr virus-positive gastric adenocarcinoma. Atsushi Okabe,Kie Kyon Huang,Keisuke Matsusaka,Masaki Fukuyo,Manjie Xing,Xuewen Ong,Takayuki Hoshii,Genki Usui,Motoaki Seki,Yasunobu Mano,Bahityar Rahmutulla,Teru Kanda,Takayoshi Suzuki,Sun Young Rha,Tetsuo Ushiku,Masashi Fukayama,Patrick Tan,Atsushi Kaneda Nature genetics 52 9 919 2020/09
- Cinobufagin inhibits proliferation of acute myeloid leukaemia cells by repressing c-Myc pathway-associated genes. Yoshiro Hirasaki,Atsushi Okabe,Masaki Fukuyo,Bahityar Rahmutulla,Yasunobu Mano,Motoaki Seki,Takayuki Hoshii,Takao Namiki,Atsushi Kaneda Chemico-biological interactions 360 109936 2022/06/01
- Association of frequent hypermethylation with high grade histological subtype in lung adenocarcinoma. Yuki Ito,Genki Usui,Motoaki Seki,Masaki Fukuyo,Keisuke Matsusaka,Takayuki Hoshii,Yuki Sata,Junichi Morimoto,Atsushi Hata,Takahiro Nakajima,Bahityar Rahmutulla,Taisuke Kaiho,Terunaga Inage,Kazuhisa Tanaka,Yuichi Sakairi,Hidemi Suzuki,Ichiro Yoshino,Atsushi Kaneda Cancer science 114 7 3003 2023/04/21
- Integrated enhancer regulatory network by enhancer-promoter looping in gastric cancer. Tianhui Zhu,Atsushi Okabe,Genki Usui,Ryoji Fujiki,Daichi Komiyama,Kie Kyon Huang,Motoaki Seki,Masaki Fukuyo,Hiroyuki Abe,Meng Ning,Tomoka Okada,Mizuki Minami,Makoto Matsumoto,Qin Fan,Bahityar Rahmutulla,Takayuki Hoshii,Patrick Tan,Teppei Morikawa,Tetsuo Ushiku,Atsushi Kaneda NAR cancer 6 2 zcae020 2024/06
- mTORC1-Independent IgA Production: A Unique Pathway for Gut Immune Homeostasis. Masashi Ohtani,Hideki Fujii,Takashi Watanabe,Osamu Ohara,Mikako Maruya,Sidonia Fagarasan,Takayuki Hoshii,Atsushi Hirao,Shigeo Koyasu,Masato Kubo,Satoshi Matsuda International immunology 2025/10/22
- Distinct roles of Rheb and Raptor in activating mTOR complex 1 for the self-renewal of hematopoietic stem cells. Hui Peng,Atsuo Kasada,Masaya Ueno,Takayuki Hoshii,Yuko Tadokoro,Naho Nomura,Chiaki Ito,Yusuke Takase,Ha Thi Vu,Masahiko Kobayashi,Bo Xiao,Paul F Worley,Atsushi Hirao Biochemical and biophysical research communications 495 1 1129 2018/01/01
- Correction: PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORγ. Yutaka Kurebayashi,Shigenori Nagai,Ai Ikejiri,Masashi Ohtani,Kenji Ichiyama,Yukiko Baba,Taketo Yamada,Shohei Egami,Takayuki Hoshii,Atsushi Hirao,Satoshi Matsuda,Shigeo Koyasu Cell reports 34 12 2021/03/23
- Activation of EHF via STAT3 phosphorylation by LMP2A in Epstein-Barr virus-positive gastric cancer. Wenzhe Li,Atsushi Okabe,Genki Usui,Masaki Fukuyo,Keisuke Matsusaka,Bahityar Rahmutulla,Yasunobu Mano,Takayuki Hoshii,Sayaka Funata,Nobuhiro Hiura,Masashi Fukayama,Patrick Tan,Tetsuo Ushiku,Atsushi Kaneda Cancer science 112 8 3349 2021/08
- Non-catalytic role of SETD1A promotes gastric cancer cell proliferation through the E2F4-TAF6 axis in the cell cycle. Meng Ning,Takayuki Hoshii,Takuya Nakagawa,Genki Usui,Shintaro Izumi,Kanako Hayashi,Makoto Matsumoto,Bahityar Rahmutulla,Masaki Fukuyo,Hiroyuki Abe,Tetsuo Ushiku,Atsushi Kaneda Cell death & disease 16 1 639 2025/08/23
- High-resolution characterization of gene function using single-cell CRISPR tiling screen. Lu Yang,Anthony K N Chan,Kazuya Miyashita,Christopher D Delaney,Xi Wang,Hongzhi Li,Sheela Pangeni Pokharel,Sandra Li,Mingli Li,Xiaobao Xu,Wei Lu,Qiao Liu,Nicole Mattson,Kevin Yining Chen,Jinhui Wang,Yate-Ching Yuan,David Horne,Steven T Rosen,Yadira Soto-Feliciano,Zhaohui Feng,Takayuki Hoshii,Gang Xiao,Markus Müschen,Jianjun Chen,Scott A Armstrong,Chun-Wei Chen Nature communications 12 1 4063 2021/07/01
- Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function. Takayuki Imanishi,Midori Unno,Wakana Kobayashi,Natsumi Yoneda,Satoshi Matsuda,Kazutaka Ikeda,Takayuki Hoshii,Atsushi Hirao,Kensuke Miyake,Glen N Barber,Makoto Arita,Ken J Ishii,Shizuo Akira,Takashi Saito Life science alliance 2 1 2019/02
- Tumorigenic activation around HPV integrated sites in head and neck squamous cell carcinoma. Masato Mima,Atsushi Okabe,Takayuki Hoshii,Takuya Nakagawa,Tomoya Kurokawa,Satoru Kondo,Harue Mizokami,Masaki Fukuyo,Ryoji Fujiki,Bahityar Rahmutulla,Tomokazu Yoshizaki,Toyoyuki Hanazawa,Kiyoshi Misawa,Atsushi Kaneda International journal of cancer 152 9 1847 2023/01/17
- Increase of smooth muscle cell migration and of intimal hyperplasia in mice lacking the alpha/beta hydrolase domain containing 2 gene. Keishi Miyata,Yuichi Oike,Takayuki Hoshii,Hiromitsu Maekawa,Hisao Ogawa,Toshio Suda,Kimi Araki,Ken-ichi Yamamura Biochemical and biophysical research communications 329 1 296 2005/04/01
- Metabolic regulation of osteoclast differentiation and function. Indo Y,Takeshita S,Ishii KA,Hoshii T,Aburatani H,Hirao A,Ikeda K J Bone Miner Res
- Mechanistic / mammalian target protein of rapamycin signaling in hematopoietic stem cells and leukemia. Hirao A,Hoshii T Cancer Sci 104 8 977-82
- Nucleostemin in injury-induced liver regeneration. Shugo H,Ooshio T,Naito M,Naka K,Hoshii T,Tadokoro Y,Muraguchi T,Tamase A,Uema N,Yamashita T,Nakamoto Y,Suda T,Kaneko S,Hirao A Stem Cells Dev 21 16 3044-54
- Molecular pathology of tumor-initiating cells: lessons from Philadelphia chromosome-positive leukemia. Naka K,Hoshii T,Tadokoro Y,Hirao A Pathol Int 61 9 501-8
- Abundant nucleostemin expression supports the undifferentiated properties of germ cell tumors. Uema N,Ooshio T,Harada K,Naito M,Naka K,Hoshii T,Tadokoro Y,Ohta K,Ali MA,Katano M,Soga T,Nakanuma Y,Okuda A,Hirao A Am J Pathol 183 2 592-603
- PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORγ. Kurebayashi Y,Nagai S,Ikejiri A,Ohtani M,Ichiyama K,Baba Y,Yamada T,Egami S,Hoshii T,Hirao A,Matsuda S,Koyasu S Cell Rep 1 4 360-73
- Cutting edge: mTORC1 in intestinal CD11c+ CD11b+ dendritic cells regulates intestinal homeostasis by promoting IL-10 production. Ohtani M,Hoshii T,Fujii H,Koyasu S,Hirao A,Matsuda S J Immunol 188 10 4736-40
- mTORC1 is essential for leukemia propagation but not stem cell self-renewal. Hoshii T,Tadokoro Y,Naka K,Ooshio T,Muraguchi T,Sugiyama N,Soga T,Araki K,Yamamura K,Hirao A J Clin Invest 122 6 2114-29
- NKX2.2 suppresses self-renewal of glioma-initiating cells. 2011/02
Conference Presentations
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「mTOR複合体1による白血病幹細胞自己複製維持メカニズムの解明」(2012-2013)
○「mTOR複合体1による正常造血幹細胞・白血病幹細胞制御機構の解明」(2010-2011)
○「mTOR複合体1を介した細胞分化制御機構の解明」(2011-2011)