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Researcher Information

last modified:2018/02/14

Associate Professor NAGATA Naoto

Mail Laboratory Website

Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences Department of Cellular and Molecular Function Analysis
Lecturer

College and School Educational Field


Laboratory

Department of Cellular and Molecular Function Analysis TEL:076-265-2453 FAX:076-234-4235

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor 200703 Completed
【Academic background(Bachelor's Degree)】
Kanazawa Uiversity 200203

Career

Kanazawa University Graduate School of Natural Science Assistant Professor(2007/04/01-2010/01/31)
University of California, Davis Department of Nutrition Postdoctoral fellow(2010/02/01-2012/08/31)
Kanazawa University Assistant Professor(2012/10/01-2016/08/31)
Kanazawa University Graduate School of Medical Science Department of Cellular and Molecular Function Analysis Assistant professor(2016/09/01-2017/06/30)
Kanazawa University Graduate School of Medical Science Department of Cellular and Molecular Function Analysis Lecturer(2017/07/01-)

Year & Month of Birth

1978/09

Academic Society

Japanese Association for Protein Phosphatase Research
The Japanese Biochemical Society
The Japan Society of Hepatology

Award

Specialities

Metabolomics、Gastroenterology、Food science、Medical pharmacy

Speciality Keywords

Energy metabolism, Obesity

Research Themes

Finding a new way to stimulate thermogenesis to combat obesity

Books

  •  Naoto Nagata, Tsuguhito Ota BIO INDUSTRY 2018/02/12
  •  Naoto Nagata, Toshinari Takamura Fatty liver and insulin resistance IGAKU SHUPPAN 2013/09

Papers

  •  Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice. Nagata N, Xu L, Kohno S, Ushida Y, Aoki Y, Umeda R, Fuke N, Zhuge F, Ni Y, Nagashimada M, Takahashi C, Suganuma H, Kaneko S, Ota T. Diabetes 66 5 1222-1236 2017/05/01 
  •  Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo Funaki M, Kitabayashi J, Shimakami T, Nagata N, Sakai Y, Takegoshi K, Okada H, Murai K, Shirasaki T, Oyama T, Yamashita T, Ota T, Takuwa Y, Honda M, Kaneko S Scientific Reports 7 1 16978 2017/12/05
  •  SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice. Xu L, Nagata N, Nagashimada M, Zhuge F, Ni Y, Chen G, Mayoux E, Kaneko S, Ota T. EBioMedicine 20 137-149 2017/06/01
  •  Peretinoin, an acyclic retinoid, suppresses steatohepatitis and tumorigenesis by activating autophagy in mice fed an atherogenic high-fat diet. Okada H, Takabatake R, Honda M, Takegoshi K, Yamashita T, Nakamura M, Shirasaki T, Sakai Y, Shimakami T, Nagata N, Takamura T, Tanaka T, Kaneko S. Oncotarget 8 25 39978-39993 2017/06/20
  •  Branched-chain amino acids prevent hepatic fibrosis and development of hepatocellular carcinoma in a non-alcoholic steatohepatitis mouse model. Takegoshi K, Honda M, Okada H, Takabatake R, Matsuzawa-Nagata N, Campbell JS, Nishikawa M, Shimakami T, Shirasaki T, Sakai Y, Yamashita T, Takamura T, Tanaka T, Kaneko S. Oncotarget 8 11 18191-18205 2017/03/14

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  •  β-Cryptoxanthin exerts greater cardioprotective effects on cardiac ischemia-reperfusion injury than astaxanthin by attenuating mitochondrial dysfunction in mice. Pongkan W, Takatori O, Ni Y, Xu L, Nagata N, Chattipakorn SC, Usui S, Kaneko S, Takamura M, Sugiura M, Chattipakorn N, Ota T. Molecular nutrition & food research. 2017/05/20
  •  DPP-4 inhibition by linagliptin attenuates obesity-related inflammation and insulin resistance by regulating M1/M2 macrophage polarization. Zhuge F, Ni Y, Nagashimada M, Nagata N, Xu L, Mukaida N, Kaneko S, Ota T. Diabetes 2016/07/21
  •  Micronutrient Antioxidants and Nonalcoholic Fatty Liver Disease. Chen G, Ni Y, Nagata N, Xu L, Ota T. Int J Mol Sci. 17 9 1379 2016/08/23
  •  LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance. Lan F1, Misu H, Chikamoto K, Takayama H, Kikuchi A, Mohri K, Takata N, Hayashi H, Matsuzawa-Nagata N, Takeshita Y, Noda H, Matsumoto Y, Ota T, Nagano T, Nakagen M, Miyamoto K, Takatsuki K, Seo T, Iwayama K, Tokuyama K, Matsugo S, Tang H, Saito Y, Yamagoe S, Kaneko S, Takamura T. Diabetes 63 5 1649-64 2014/05
  •  Central Insulin Action Activates Kupffer Cells by Suppressing Hepatic Vagal Activation via the Nicotinic Alpha 7 Acetylcholine Receptor. Kimura K, Tanida M, Nagata N, Inaba Y, Watanabe H, Nagashimada M, Ota T, Asahara S, Kido Y, Matsumoto M, Toshinai K, Nakazato M, Shibamoto T, Kaneko S, Kasuga M, Inoue H Cell Reports 14 10 2362-74 2016/05
  •  Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with Vitamin E Yinhua Ni, Mayumi Nagashimada, Fen Zhuge, Lili Zhan, Naoto Nagata, Akemi Tsutsui, Yasuni Nakanuma, Shuichi Kaneko & Tsuguhito Ota Scientific Reports 5 17192 2015/11
  •  Prevention and reversal of lipotoxicity-induced hepatic insulin resistance and steatohepatitis in mice by an antioxidant carotenoid, β-cryptoxanthin. Ni Y1, Nagashimada M, Zhan L, Nagata N, Kobori M, Sugiura M, Ogawa K, Kaneko S, Ota T. Endocrinology 156 3 987 2015/05
  •  Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells. Ishikura K, Misu H, Kumazaki M, Takayama H, Matsuzawa-Nagata N, Tajima N, Chikamoto K, Lan F, Ando H, Ota T, Sakurai M, Takeshita Y, Kato K, Fujimura A, Miyamoto K, Saito Y, Kameo S, Okamoto Y, Takuwa Y, Takahashi K, Kidoya H, Takakura N, Kaneko S, Takamura T. Diabetologia 57 9 1968-76 2014/09
  •  Protein Tyrosine Phosphatase 1B Regulates Pyruvate Kinase M2 Tyrosine Phosphorylation Bettaieb Ahmed, Bakke Jesse, Nagata Naoto, Fawaz Haj JOURNAL OF BIOLOGICAL CHEMISTRY 288 24 17360-17371 2013/06
  •  Regulation of the SNARE-interacting protein Munc18c tyrosine phosphorylation in adipocytes by protein-tyrosine phosphatase 1B Bakke J, Bettaieb A, Nagata N, Matsuo K, Haj FG. CELL COMMUNICATION AND SIGNALING 11 57 2013/08
  •  Soluble Epoxide Hydrolase Deficiency or Inhibition Attenuates Diet-induced Endoplasmic Reticulum Stress in Liver and Adipose Tissue Bettaieb Ahmed, Nagata Naoto, AbouBechara Daniel, Fawaz Haj JOURNAL OF BIOLOGICAL CHEMISTRY 288 20 14189-14199 2013/05
  •  Hepatic Src Homology Phosphatase 2 Regulates Energy Balance in Mice Nagata Naoto, Matsuo Kosuke, Bettaieb Ahmed, Fawaz Haj ENDOCRINOLOGY 153 7 3158-3169 2012/07
  •  Metformin Prevents and Reverses Inflammation in a Non-Diabetic Mouse Model of Nonalcoholic Steatohepatitis Yuki Kita, Toshinari Takamura, Hirofumi Misu, Tsuguhito Ota, Seiichiro Kurita, Yumie Takeshita, Masafumi Uno, Naoto Matsuzawa-Nagata, Ken-ichiro Kato, Hitoshi Ando, Akio Fujimura, Koji Hayashi, Toru Kimura, Yinhua Ni, Toshiki Otoda, Ken-ichi Miyamoto, Yoh Zen, Yasuni Nakanuma, Shuichi Kaneko PLOS ONE 7 9 e43056 2012/09 
  •  Adipose-specific deletion of Src homology phosphatase 2 does not significantly alter systemic glucose homeostasis Ahmed Bettaieb, Kosuke Matsuo, Izumi Matsuo, Naoto Nagata, Samah Chahed, Siming Liu, Fawaz G. Haj METABOLISM-CLINICAL AND EXPERIMENTAL 60 8 1193-1201 2011/08 
  •  Differential regulation of endoplasmic reticulum stress by protein tyrosine phosphatase 1B and T cell protein tyrosine phosphatase. Ahmed Bettaieb, Siming Liu, Yannan Xi, Naoto Nagata, Kosuke Matsuo, Izumi Matsuo, Samah Chahed, Jesse Bakke, Heike Keilhack, Tony Tiganis, Fawaz G Haj JOURNAL OF BIOLOGICAL CHEMISTRY 286 11 9225-9235 2011/03
  •  Regulation of brown fat adipogenesis by protein tyrosine phosphatase 1B. Kosuke Matsuo, Ahmed Bettaieb, Naoto Nagata, Izumi Matsuo, Heike Keilhack, Fawaz G Haj  PLOS One 6 1 e16446 2011/01
  •   A liver-derived secretory protein, selenoprotein P, causes insulin resistance. Hirofumi Misu, Toshinari Takamura, Hiroaki Takayama, Hiroto Hayashi, Naoto Matsuzawa-Nagata, Seiichiro Kurita, Kazuhide Ishikura, Hitoshi Ando, Yumie Takeshita, Tsuguhito Ota, Masaru Sakurai, Tatsuya Yamashita, Eishiro Mizukoshi, Taro Yamashita, Masao Honda, Ken-ichi Miyamoto, Tetsuya Kubota, Naoto Kubota, Takashi Kadowaki, Han-Jong Kim, In-kyu Lee, Yasuhiko Minokoshi, Yoshiro Saito, Kazuhiko Takahashi, Yoshihiro Yamada, Nobuyuki Takakura, Shuichi Kaneko Cell Metabolism 12 5 483-495 2010/11
  •  Altered glucose homeostasis in mice with liver-specific deletion of Src homology phosphatase 2. Kosuke Matsuo, Mirela Delibegovic, Izumi Matsuo, Naoto Nagata, Siming Liu, Ahmed Bettaieb, Yannan Xi, Kazushi Araki, Wentian Yang, Barbara B Kahn, Benjamin G Neel, Fawaz G Haj  JOURNAL OF BIOLOGICAL CHEMISTRY 285 51 39750-39758 2010/12
  •  Protecting cisplatin-induced nephrotoxicity with cimetidine does not affect antitumor activity. Hiromu Katsuda, Mariko Yamashita, Hideyuki Katsura, Jia Yu, Yoshihiro Waki, Naoto Nagata, Yoshimichi Sai, Ken-Ichi Miyamoto BIOLOGICAL & PHARMACEUTICAL BULLETIN 33 11 1867 2010/01
  •  Clock gene expression in peripheral leucocytes of patients with type 2 diabetes. Ando H,Takamura T,Matsuzawa-Nagata N,Shima KR,Eto T,Misu H,Shiramoto M,Tsuru T,Irie S,Fujimura A,Kaneko S DIABETOLOGIA 52 2 329-35 2008/10
  •  Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria. Seiji Nakamura, Toshinari Takamura, Naoto Matsuzawa-Nagata, Hiroaki Takayama, Hirofumi Misu, Hiroyo Noda, Satoko Nabemoto, Seiichiro Kurita, Tsuguhito Ota, Hitoshi Ando, Ken-Ichi Miyamoto, Shuichi Kaneko Journal of Biological Chemistry 284 22 14809 2009/04
  •  The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis. Hitoshi Ando, Toshinari Takamura, Naoto Matsuzawa-Nagata, Kosuke R Shima, Seiji Nakamura, Masafumi Kumazaki, Seiichiro Kurita, Hirofumi Misu, Naoyuki Togawa, Tatsunobu Fukushima, Akio Fujimura, Shuichi Kaneko BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 380 3 684 2009/04
  •  Cross talk of tumor necrosis factor-alpha and the renin-angiotensin system in tumor necrosis factor-alpha-induced plasminogen activator inhibitor-1 production from hepatocytes. Takeshita Y,Takamura T,Ando H,Hamaguchi E,Takazakura A,Matsuzawa-Nagata N,Kaneko S European Journal of Pharmacology  579 1-3 426-32 2008/01
  •  Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity. Matsuzawa-Nagata N,Takamura T,Ando H,Nakamura S,Kurita S,Misu H,Ota T,Yokoyama M,Honda M,Miyamoto K,Kaneko S Metabolism 57 8 1071-7 2008/06
  •  Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells Nomura M, Takahashi T, Nagata N, Tsutsumi K, Kobayashi S, Akiba T, Yokogawa K, Moritani S, Miyamoto K BIOLOGICAL & PHARMACEUTICAL BULLETIN 31 7 1403-1409 2008/07
  •  Obesity upregulates genes involved in oxidative phosphorylation in livers of diabetic patients. Takamura T,Misu H,Matsuzawa-Nagata N,Sakurai M,Ota T,Shimizu A,Kurita S,Takeshita Y,Ando H,Honda M,Kaneko S Obesity (Silver Spring) 16 12 2601-9 2008/12
  •  Olmesartan ameliorates a dietary rat model of non-alcoholic steatohepatitis through its pleiotropic effects. Kurita S,Takamura T,Ota T,Matsuzawa-Nagata N,Kita Y,Uno M,Nabemoto S,Ishikura K,Misu H,Ando H,Zen Y,Nakanuma Y,Kaneko S EUROPEAN JOURNAL OF PHARMACOLOGY 588 2-3 316-24 2008/07
  •  Soybean fat supplementation controls insulin resistance caused by fat-free total parenteral nutrition. Ohkawa H,Fukuwa C,Matsuzawa-Nagata N,Yokogawa K,Omura K,Miyamoto K JOURNAL OF PHARMACY AND PHARMACOLOGY 60 4 461-5 2008/04
  •  Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis. Uno M,Kurita S,Misu H,Ando H,Ota T,Matsuzawa-Nagata N,Kita Y,Nabemoto S,Akahori H,Zen Y,Nakanuma Y,Kaneko S,Takamura T HEPATOLOGY 48 1 109-18 2008/07
  •  Gene expression profiles in peripheral blood mononuclear cells reflect the pathophysiology of type 2 diabetes Takamura T, Honda M, Sakai Y, Ando H, Shimizu A, Ota T, Sakurai M, Misu H, Kurita S, Matsuzawa-Nagata N, Uchikata M, Nakamura S, Matoba R, Tanino M, Matsubara K, Kaneko S BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 361 2 379-384 2007/09
  •  Genes involved in oxidative phosphorylation are coordinately upregulated with fasting hyperglycaemia in livers of patients with type 2 diabetes Misu H, Takamura T, Matsuzawa N, Shimizu A, Ota T, Sakurai M, Ando H, Arai K, Yamashita T, Honda M, Kaneko S Diabetologia 50 2 268-277 2007/02
  •  Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis 2. Ota T, Takamura T, Kurita S, Matsuzawa N, Kita Y, Uno M, Akahori H, Misu H, Sakurai M, Zen Y, Nakanuma Y, Kaneko S Gastroenterology  132 1 282-293 2007/01
  •  Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet. Matsuzawa N,Takamura T,Kurita S,Misu H,Ota T,Ando H,Yokoyama M,Honda M,Zen Y,Nakanuma Y,Miyamoto K,Kaneko S HEPATOLOGY 46 5 1392-403 2007/11
  •  Regulation of adiponectin receptor expression in human liver and a hepatocyte cell line. Shimizu A,Takamura T,Matsuzawa N,Nakamura S,Nabemoto S,Takeshita Y,Misu H,Kurita S,Sakurai M,Yokoyama M,Zen Y,Sasaki M,Nakanuma Y,Kaneko S Metabolism 56 11 1478-85 2007/11

Conference Presentations

  • Down-regulation of Ptpn11 in myeloid cells mitigates hepatic fibrosis in mice fed a CDAA diet(conference:The 3rd Japan-Taiwan Bilateral Conference on Protein Phosphatase)(2017/11/18)
  • Sulforaphane-mediated Nrf2 activation ameliorates obesity and fatty liver disease in obese mice(conference:ConBio2017)(2017/12/09)
  • Nrf2 activation improves high fat diet-induced inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status in liver(conference:ADA76th Scientific Session)(2016/06)
  • Broccoli sprouts improve high fat diet-induced inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status in liver(conference:ACN2015)(2015/05)
  • Lycopene Attenuates the Inflammatory Adipose Tissue Response to High Fat Feeding by Regulating both Macrophage Recruitment and M1/M2 Status(conference:ADA74th Scientific Session)(2014/06)

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  • staxanthin ameliorates hepatic insulin resistance and inhibits the progression of lipotoxic model of nonalcoholic steatohepatitis(conference:IDF2013)(2013/12)

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「ブロッコリースプラウト抽出物による炎症制御及びエネルギー代謝調節機構の解明」(2015-2017) 
○「タンパク質チロシンフォスファターゼShp2による炎症制御機構の解明」(2013-2014) 
○「脂肪肝炎の新規治療法の開発-酪酸菌のプロバイオティクス効果の検討 」(2008-2010) 

Classes (Bachelors)

○Pharmacology(2017)
○Pharmacology(2016)

Classes (Graduate Schools)

○Molecular Function Analysis(2017)
○Molecular Function Analysis(2017)

International Project

International Students

Lecture themes

Others (Social Activities)

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