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Researcher Information

last modified:2024/06/19

Assistant Professor HARASHIMA, Ai

Mail

Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field


Laboratory

 TEL:076-265-2184

Academic Background

Career

(2016/02-)
(2011/04-2012/12)
(2007/04-2011/03)
(2013/01-2016/01)
(2018/01-2021/01)

Year & Month of Birth

Academic Society


IMARS

Award

Specialities

、、、、

Speciality Keywords

Research Themes

Books

Papers

  •   Dual nature of RAGE in host reaction and nurturing the mother-infant bond.  Oshima Y, Harashima A, Munesue S, Kimura K, Leerach N, Goto H, Tanaka M, Niimura A, Hayashi K, Yamamoto H, Higashida H, Yamamoto Y. Int J Mol Sci 23 4 2086 2022/02
  •  Use of cocultures to measure the blood-brain barrier permeability of oxytocin. Yamamoto Y, Harashima A, Munesue S, Higashida H. Methods Mol Biol 2384 247-255 2022/01
  •   Postprandial induction of neutrophil extracellular trap formation in the blood. Oshima Y, Tanaka M, Leerach N, Harashima A, Munesue S, Kimura K, Goto H, Hayashi K, Niimura A, Yamamoto Y. Glycative Stress Res 8 4 183-189 2021/12
  •  An improved sample extraction method reveals that plasma receptor for advanced glycation end-products (RAGE) modulates circulating free oxytocin in mice. Cherepanov SM, Gerasimenko M, Yuhi T, Shabalova A, Zhu H, Yokoyama S, Salmina AB, Munesue S, Harashima A, Yamamoto Y, Higashida H. Peptides 146 170649 2021/09
  •  Dynamic switch of immunity and antitumor effects of metformin in rat spontaneous esophageal carcinogenesis.  Takei R, Miyashita T, Takada S, Tajima H, Ninomiya I, Takamura H, Fushida S, Harashima A, Munesue S, Yagi S, Inaki N, Ohta T, Yamamoto Y. Cancer Immunol 71 4 791-793 2021/04

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  •  Pyridoxamine improves diabetes-evoked delayed bone repair in mice.  Ugaji S, Kimura K, Yamamoto Y, Munesue S, Harashima A, Aikawa T, Yoshida Y, Hamada T, Hikichi T, Matsubara H, Tsuchiya H. J Transl Sci in press in press in press 2021/03
  •  Receptor for advanced glycation end-products (RAGE) plays a critical role in retrieval behavior of mother mice at early postpartum. Gerasimenko M, Lopatina O, Munesue S, Harashima A, Yokoyama S, Yamamoto Y, Higashida H. Physiol Behav in press in press in press 2021/03
  •  RAGE signaling antagonist suppresses mouse macrophage foam cell formation Nontaphat LEERACH, Seiichi MUNESUE, Ai HARASHIMA, Kumi KIMURA, Yu OSHIMA, Shuhei KAWANO, Mariko TANAKA, Akane NIIMURA, Natthiya SAKULSAK, Hiroshi YAMAMOTO, Osamu HORI, Yasuhiko YAMAMOTO BBRC in press in press in press 2021/03
  •  Transport of oxytocin to the brain after peripheral administration by membrane-bound or soluble forms of receptors for advanced glycation end-products.  Munesue S, Liang MingKun, Harashima A, Zhong J, Furuhara K, Boitsova E, Cherepanov SM, Gerasimenko M, Yuhi T, Yamamoto Y, Higashida H.  J Neuroendocrinol  in press in press in press 2021/03
  •  Glycation reaction and the role of the receptor for advanced glycation end-products in immunity and social behavior.  Leerach N, Harashima A, Munesue S, Kimura K, Oshima Y, Goto H, Yamamoto H, Higashida H, Yamamoto Y. Glycoconj J  in press in press in press 2020
  •  Aquaporin 1 elicits cell motility and coordinates vascular bed formation by downregulating thrombospondin type-1 domain-containing 7A in glioblastoma. Oishi M, Munesue S, Harashima A, Nakada M, Yamamoto Y, Hayashi Y.  Cancer Med 9 11 3904-3917 2020
  •  CD38, CD157 and RAGE as molecular determinants for social behavior. Higashida H, Hashii M, Tanaka Y, Matsukawa S, Higuchi Y, Gabata R, Tsubomoto M, Seishima N, Teramachi M, Kamijima T, Hattori T, Hori O, Tsuji C, Cherepanov S, Shabalova A, Gerasimenko M, Minami K, Yokoyama S, Munesue S, Harashima A, Yamamoto Y, Salmina A, Lopatina O. Cells 9 1 E62 2019
  •  Protective role of endogenous secretory RAGE against contact hypersensitivity in mouse ear skin. Sagara A, Harashima A, Munesue S, Kimura K, Leerach N, Oshima Y, Kinoshita Y, Sakai N, Kaneko S, Wada T, Tsuneyama K, Yamamoto H, Yamamoto Y.  Glycative Stress Res 6 4 270 2019
  •  Neuroprotective effects of endogenous secretory receptor for advanced glycation end-products in brain ischemia.  Shimizu Y, Harashima A, Munesue S, Oishi M, Hattori T, Hori O, Kitao Y, Yamamoto H, Leerach N, Nakada M, Yamamoto Y, Hayashi Y.  Aging Dis in press in press 2019
  •  Monitoring of heat shock response and phenotypic changes in hepatocellular carcinoma after heat treatment.  Zaimoku R, Miyashita T, Tajima H, Takamura H, Harashima A, Munesue S, Yamamoto Y, Ninomiya I, Fushida S, Harada K.  Anticancer Res 39 10 5393 2019
  •  Clonal hematopoiesis by SLIT1-mutated hematopoietic stem cells due to a breakdown of the autocrine loop involving Slit1 in acquired aplastic anemia. Hosokawa K, Mizumaki H, Elbadry M, Saito C, Espinoza JL, An DTT, Katagiri T, Harashima A, Kikuchi A, Kanai A, Matsui H, Inaba T, Taniwaki M, Yamamoto Y, Nakao S. Leukemia 33 2732 2019
  •  Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice. Yamamoto Y, Liang M, Munesue S, Deguchi K, Harashima A, Furuhara K, Yuhi T, Zhong J, Akther S, Goto H, Eguchi Y, Kitao Y, Hori O, Shiraishi Y, Ozaki N, Shimizu Y, Kamide T, Yoshikawa A, Hayashi Y, Nakada M, Lopatina O, Gerasimenko M, Komleva Y, Malinovskaya N, Salmina AB, Asano M, Nishimori K, Shoelson SE, Yamamoto H, Higashida H. Commun Biol  2 76 2019
  •   In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system.  El-Far A, Munesue S, Harashima A, Sato A, Shindo M, Nakajima S, Inada M, Tanaka M, Takeuchi A, Tsuchiya H, Yamamoto H, Shaheen HME, El-Sayed YS, Kawano S, Tanuma S, Yamamoto Y.  Oncology Lett 15 4 4627-4634 2018
  •   Anti-tumor effects of a non-steroidal anti-inflammatory drug zaltoprofen on chondrosarcoma via activating peroxisome proliferator-activated receptor gamma and suppressing matrix metalloproteinase-2 expression.  Higuchi T, Takeuchi, A, Munesue S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Inatani H, Shimozaki S, Kato T, Aoki Y, Abe K, Taniguchi Y, Aiba H, Murakami H, Harashima A, Yamamoto Y, Tsuchiya H.  Cancer Med 75 5 1944-1954 2018
  •  Citrullinated histone H3: early biomarker of neutrophil extracellular traps in septic liver damage.  Nomura K, Miyashita T, Yamamoto Y, Munesue S, Harashima A, Takayama H, Fushida S, Ohta T.  J Surg Res  234 132-138 2018
  •   Intestinal transepithelial permeability of oxytocin into the blood is dependent on the receptor for advanced glycation end products in mice.  Higashida H, Furuhara K, Yamauchi AM, Deguchi K, Harashima A, Munesue S, Lopatina O, Gerasimenko M, Salmina AB, Zhang JS, Kodama H, Kuroda H, Tsuji C, Suto S, Yamamoto H, Yamamoto Y.  Sci Rep  in ress 2017
  •  Low-dose paclitaxel suppresses the induction of M2 macrophages in gastric cancer. Yamaguchi T, Fushida S, Yamamoto Y, Tsukada T, Kinoshita J, Oyama K, Miyashita T, Tajima H, Ninomiya I, Munesue S, Harashima A, Harada S, Yamamoto H and Ohta T. Oncology Rep 37 3341-3350 2017
  •  Contribution of methylglyoxal to delayed healing of bone injury in diabetes. Aikawa T, Matsubara H, Ugaji S, Shirakawa J, Nagai R, Munesue S, Harashima A, Yamamoto Y, Tsuchiya H Mol Med Rep in press 2017
  •   Nurture vs. nature in diabetic vasculopathy: roles of advanced glycation endproducts and the receptor for them. Yamamoto Y, Yonekura H, Sakurai S, Tanaka N, Li H, Myint KM, Kim CH, Harashima A, Osawa M, Takeuchi M, Watanabe T, Yamamoto H.  International Congress Series, Atherosclerosis XIII  1264 164-167 2004
  •  Receptor for advanced glycation end products is a promising target of diabetic nephropathy. Yamamoto Y, Doi T, Kato I, Shinohara H, Sakurai S, Yonekura H, Watanabe T, Myint KM, Harashima A, Takeuchi M, Takasawa S, Okamoto H, Hashimoto N, Asano M and Yamamoto H. Ann N Y Acad Sci  1043 562-566 2005
  •  Blockade of diabetic vascular injury by controlling of AGE-RAGE system. Myint KM, Yamamoto Y, Sakurai S, Harashima A, Watanabe T, Li H, Takeuchi A, Yoshimura K, Yonekura H and Yamamoto H Curr Drug Targets 6 447-452 2005
  •   RAGE in diabetic nephropathy.  Yamamoto H, Watanabe T, Yamamoto Y, Yonekura H, Munesue S, Harashima A, Ooe K, Hossain S, Saito H and Murakami N.  Curr Mol Med  7 752-757 2007
  •  AVAQ594-597 deletion of the TfR2 gene in a Japanese family with hemochromatosis.  Hattori A, Wakusawa S, Hayashi H, Harashima A, Sanae F, Kawanaka M, Yamada G, Yano M and Yoshioka K. Hepatol Res  26 154-156 2003
  •  Compound load of copper and iron in the livers of pretreatment patients with wilson’s disease.  Harashima A, Hattori A, Hayashi H, Wakusawa S, Kusakabe A, Fujita Y, Tanaka M, Yano M and Yoshioka K J Tra Elem Exp Med  17 65-73 2004
  •  Identification of mouse ortholog of endogenous secretory receptor for advanced glycation end-products. : structure, function and expression. Harashima A, Yamamoto Y, Cheng C, Tsuneyama K, Myint KM, Takeuchi A, Yoshimura K, Li H, Watanabe T, Takasawa S, Okamoto H, Yonekura H and Yamamoto Y. Biochem J 396 109-115 2006
  •  RAGE control of diabetic nephropathy in a mouse model.: effects of RAGE gene disruption and administration of low-molecular weight heparin.  Myint KM, Yamamoto Y, Doi T, Kato I, Harashima A, Yonekura H, Watanabe T, Shinohara H, Takeuchi M, Hashimoto N, Asano M, Takasawa S, Okamoto H and Yamamoto H Diabetes 55 2510-2500 2006
  •  hosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase, PKR, constitutes a novel mechanism of translational regulation and cellular defense. Harashima A, Guettouche T and Barber GN Genes Develop 24 2640-2653 2010
  •  Preventive effect of salicylate and pyridoxamine on diabetic nephropathy. Abouzed TK, Munesue S, Harashima A, Masuo Y, Kato Y, Khailo KKK, Yamamoto H, Yamamoto Y  J Diabetes res 2016 1786789 2016
  •  Short-chain aldehyde-derived ligands for RAGE and their actions on endothelial cells. Yamamoto Y, Yonekura H, Watanabe T, Sakurai S, Li H, Harashima A, Myint KM, Osawa M, Takeuchi A, Takeuchi M and Yamamoto H. Diabetes Res Clin Pract 77 S30-S40 2007
  •  cAMP ameliorates inflammation by modulation of macrophage receptor for advanced glycation end-products.  Motoyoshi S, Yamamoto Y, Munesue S, Igawa H, Harashima A, Saito H, Han D, Watanabe T, Sato H and Yamamoto H. Biochem J 463 75-82 2014
  •  STING recognition of cytoplasmic DNA instingates cellular defense.  Abe T*, Harashima A*, Xia T, Konno H, Konno K, Morales A, Anh J, Gutman D and Barber GN. Mol Cell  50 5-15 2013
  •  Tumor-associated macrophages of the M2 phenotype contribute to progression in gastric cancer with peritoneal dissemination. Yamaguchi T, Fushida S, Yamamoto Y, Tsukada T, Kinoshita J, Oyama K, Miyashita T, Tajima H, Ninomiya I, Munesue S, Harashima A, Harada S, Yamamoto H, Ohta T. Gastric Cancer 19 4 1052-65 2015
  •  Septic Shock Is Associated with Receptor for Advanced Glycation End Products Ligation of LPS Yamamoto, Yasuhiko;Harashima, Ai;Saito, Hidehito;Tsuneyama, Koichi;Munesue, Seiichi;Motoyoshi, So;Han, Dong;Watanabe, Takuo;Asano, Masahide;Takasawa, Shin;Okamoto, Hiroshi;Shimura, Satoshi;Karasawa, Tadahiro;Yonekura, Hideto;Yamamoto, Hiroshi JOURNAL OF IMMUNOLOGY 186 5 3248-3257 2011
  •  Low molecular weight heparin suppresses receptor for advanced glycation end products-mediated expression of malignant phenotype in human fibrosarcoma cells Takeuchi, Akihiko; Yamamoto, Yasuhiko; Munesue, Seiichi; Harashima, Ai; Watanabe, Takuo; Yonekura, Hideto; Yamamoto, Hiroshi; Tsuchiya, Hiroyuki Cancer Science 104 6 740-749 2013/06/01 
  •  Low molecular Weight Heparin Suppresses RAGE-mediated Expression of Malignant Phenotype in Human Fibrosarcoma Cells. Takeuchi A, Yamamoto Y, Munesue S, Harashima A, Watanabe T, Yonekura H, Yamamoto Y and Tsuchiya H. Cancer Sci 104 740-749

Conference Presentations

  • 可溶型RAGEは脳血管内皮細胞上の膜型RAGEによる血中オキシトシンの脳内輸送を阻害しない(2020/11/06)
  • Drug library screening to identify new compounds for inducing ectodomain shedding of RAGE and formation of soluble RAGE(conference:International Maillard Reaction Society)(2018/09/10)
  • In vitro anticancer effects of a novel RAGE inhibitor on suppression of tumor malignant phenotypes in human fibrosarcoma cells(conference:International Maillard Reaction Society)(2018/09/10)
  • Impact of inhibiting RAGE-dependent Rac1 activities on AGE-induced macrophage invasion and lipid accumulation(conference:JMARS)(2018/10/06)
  • Preventive effect of salicylate and pyridoxamine on type I diabetic nephrophathy.(2017/12/06)

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  • In vitro effects of a novel RAGE inhibitor on tumor malignancy in human fibrosarcoma HT1080 cells(2017/12/06)
  • Drug library screening to identify candidates for inducing ectodomain shedding of RAGE and formation of soluble RAGE(2017/11/18)
  • Novel polymorphisms in promoter region of human glyoxalase 1 regulate its transcription and are associated with aging-related diseases (conference:Keystone Symposia Conference Aging and Mechanisms of Aging-Related Disease)(2017/05/16)
  • Effects of a novel RAGE inhibitor on suppression of tumor malignant phenotypes in human fibrosarcoma cells(2017/11/18)
  • Insufficient leptin action induces RAGE expression and triggers pancreatic beta-cell failure type 2 diabetes.(conference:12th International Symposium on the Maillard Reaction (ISMR) )
  • Neuroprotective effects of endogenous secretory rage in ischemic cerebrovasculr diseases.(conference:12th International Symposium on the Maillard Reaction (ISMR) )(2015/09)
  • Glyoxalase1 promoter polymorphism regulates gene transcription(2016/09/25)
  • Low-molecular weight heparin inhibits human fibrosarcoma cell proliferation, migration and invasion by blocking RAGE signaling(2013/09/13)

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「線虫glad-4/GDL1遺伝子のエピジェネティクスな発現調節機構の解明」(2019-2021) 
○「オキシトシンの血液脳関門移行に関わる分子装置の解明と愛情の構築研究」(2018-2020) 
○「Glyoxalase1遺伝子多型に基づく統合失調症の病態解明と新規治療薬の創出」(2018-2020) 
○「解毒酵素グリオキザレースIの新規転写発現調節機構の解明」(2014-2015) 
○「グリオキザレース1の新規遺伝子多型による転写発現調節機構の解明」(2016-2017) 
○「Glyoxalase Iの転写発現制御機構の解析」

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Biochemistry 2(2021)
○Biochemistry 2(2020)
○Biochemistry2(2019)
○Biochemistry2(2017)
○Biochemistry2(2017)

Classes (Graduate Schools)

○Molecular Biology of the Cardiovascular System(2017)
○Molecular Biology of the Cardiovascular System(2017)
○Molecular Biology of the Cardiovascular System(2016)
○Molecular Biology of the Cardiovascular System(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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