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last modified：2025/04/09
Associate Professor MAEJIMA, Takashi
Faculty, Affiliation
Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences
College and School Educational Field
Laboratory
Academic Background
Career
Year & Month of Birth
Academic Society
Award
○Inoue Research Award for Young Scientists(2003/02)
○18th Kanazawa University Juzen Medical Award(2021/12)
Specialities
Neurophysiology/General neuroscience、Basic/Social brain science、General physiology
Speciality Keywords
Research Themes
Books
Papers
- In vivo recording of the circadian calcium rhythm in Prokineticin 2 neurons of the suprachiasmatic nucleus. Kaito Onodera,Yusuke Tsuno,Yuichi Hiraoka,Kohichi Tanaka,Takashi Maejima,Michihiro Mieda Scientific reports 13 1 16974 2023/10/09
- Action sequence learning is impaired in genetically modified mice with the suppressed GABAergic transmission from the thalamic reticular nucleus to the thalamus Takako Ohno-Shosaku,Mitsugu Yoneda,Takashi Maejima,Mohan Wang,Yui Kikuchi,Kaito Onodera,Yuji Kanazawa,Chitoshi Takayama,Michihiro Mieda Neuroscience 2023/09
- In vivo recording of suprachiasmatic nucleus dynamics reveals a dominant role of arginine vasopressin neurons in circadian pacesetting Yusuke Tsuno,Yubo Peng,Shin-ichi Horike,Mohan Wang,Ayako Matsui,Kanato Yamagata,Mizuki Sugiyama,Takahiro J. Nakamura,Takiko Daikoku,Takashi Maejima,Michihiro Mieda PLOS Biology 21 8 2023/08/29
- Isolation of ferret astrocytes reveals their morphological, transcriptional, and functional differences from mouse astrocytes Jureepon Roboon,Tsuyoshi Hattori,Dinh Thi Nguyen,Hiroshi Ishii,Mika Takarada-Iemata,Takayuki Kannon,Kazuyoshi Hosomichi,Takashi Maejima,Kengo Saito,Yohei Shinmyo,Michihiro Mieda,Atsushi Tajima,Hiroshi Kawasaki,Osamu Hori Frontiers in Cellular Neuroscience 16 877131 2022/10
- AVP neurons act as the primary circadian pacesetter cells in vivo Yusuke Tsuno,Yubo Peng,Shin-ichi Horike,Kanato Yamagata,Mizuki Sugiyama,Takahiro J. Nakamura,Takiko Daikoku,Takashi Maejima,Michihiro Mieda bioRxiv 2022/08/05
- Vasopressin neurons in the paraventricular hypothalamus promote wakefulness via lateral hypothalamic orexin neurons. Md Tarikul Islam,Florian Rumpf,Yusuke Tsuno,Shota Kodani,Takeshi Sakurai,Ayako Matsui,Takashi Maejima,Michihiro Mieda Current biology : CB 2022/07/29
- Paraventricular hypothalamic vasopressin neurons induce self-grooming in mice. Md Tarikul Islam,Takashi Maejima,Ayako Matsui,Michihiro Mieda Molecular brain 15 1 47 2022/05/23
- GABA from vasopressin neurons regulates the time at which suprachiasmatic nucleus molecular clocks enable circadian behavior. Takashi Maejima,Yusuke Tsuno,Shota Miyazaki,Yousuke Tsuneoka,Emi Hasegawa,Md Tarikul Islam,Ryosuke Enoki,Takahiro J Nakamura,Michihiro Mieda Proceedings of the National Academy of Sciences of the United States of America 118 6 2021/02/09
- Glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice. Tong Zhang,Junko Yanagida,Hironori Kamii,Shintaro Wada,Masaki Domoto,Hitoki Sasase,Satoshi Deyama,Takeshi Takarada,Eiichi Hinoi,Kenji Sakimura,Akihiro Yamanaka,Takashi Maejima,Michihiro Mieda,Takeshi Sakurai,Naoya Nishitani,Kazuki Nagayasu,Shuji Kaneko,Masabumi Minami,Katsuyuki Kaneda Addiction biology 25 1 e12723 2020/01
- RGS2 drives male aggression in mice via the serotonergic system. Mark MD,Wollenweber P,Gesk A,Kösters K,Batzke K,Janoschka C,Maejima T,Han J,Deneris ES,Herlitze S Communications biology 2 373 2019
- Monoamines Inhibit GABAergic Neurons in Ventrolateral Preoptic Area That Make Direct Synaptic Connections to Hypothalamic Arousal Neurons. Saito YC*,Maejima T*,Nishitani M,Hasegawa E,Yanagawa Y,Mieda M,Sakurai T The Journal of neuroscience : the official journal of the Society for Neuroscience 38 28 6366 2018/07
- SEROTONIN NEURONS IN THE DORSAL RAPHE MEDIATE THE ANTICATAPLECTIC ACTION OF OREXIN NEURONS BY REDUCING AMYGDALA ACTIVITY Hasegawa, E,Maejima, T,Yoshida, T,Masseck, O,Herlitze, S,Yoshioka, M,Sakurai, T,Mieda, M SLEEP MEDICINE 40 1 E127 2017/12
- Orexin modulates behavioral fear expression through the locus coeruleus Shingo Soya,Tohru M. Takahashi,Thomas J. McHugh,Takashi Maejima,Stefan Herlitze,Manabu Abe,Kenji Sakimura,Takeshi Sakurai NATURE COMMUNICATIONS 8 1 1606 2017/11
- Serotonin neurons in the dorsal raphe mediate the anticataplectic action of orexin neurons by reducing amygdala activity Emi Hasegawa,Takashi Maejima,Takayuki Yoshida,Olivia A. Masseck,Stefan Herlitze,Mitsuhiro Yoshioka,Takeshi Sakurai,Michihiro Mieda PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 114 17 E3526 2017/04
- Vertebrate Cone Opsins Enable Sustained and Highly Sensitive Rapid Control of G(i/o) Signaling in Anxiety Circuitry Olivia A. Masseck,Katharina Spoida,Deniz Dalkara,Takashi Maejima,Johanna M. Rubelowski,Lutz Wallhorn,Evan S. Deneris,Stefan Herlitze NEURON 81 6 1263 2014/03
- Modulation of firing and synaptic transmission of serotonergic neurons by intrinsic G protein-coupled receptors and ion channels. Maejima T,Masseck OA,Mark MD,Herlitze S Frontiers in integrative neuroscience 7 40 2013
- Postnatal Loss of P/Q-Type Channels Confined to Rhombic-Lip-Derived Neurons Alters Synaptic Transmission at the Parallel Fiber to Purkinje Cell Synapse and Replicates Genomic Cacna1a Mutation Phenotype of Ataxia and Seizures in Mice Takashi Maejima,Patric Wollenweber,Lena U. C. Teusner,Jeffrey L. Noebels,Stefan Herlitze,Melanie D. Mark JOURNAL OF NEUROSCIENCE 33 12 5162 2013/03
- Optogenetic Control of Motor Coordination by G(i/o) Protein-coupled Vertebrate Rhodopsin in Cerebellar Purkinje Cells Davina V. Gutierrez,Melanie D. Mark,Olivia Masseck,Takashi Maejima,Denise Kuckelsberg,Robert A. Hyde,Martin Krause,Wolfgang Kruse,Stefan Herlitze JOURNAL OF BIOLOGICAL CHEMISTRY 286 29 25848 2011/07
- Delayed Postnatal Loss of P/Q-Type Calcium Channels Recapitulates the Absence Epilepsy, Dyskinesia, and Ataxia Phenotypes of Genomic Cacna1A Mutations Melanie D. Mark,Takashi Maejima,Denise Kuckelsberg,Jong W. Yoo,Robert A. Hyde,Viral Shah,Davina Gutierrez,Rosa L. Moreno,Wolfgang Kruse,Jeffrey L. Noebels,Stefan Herlitze JOURNAL OF NEUROSCIENCE 31 11 4311 2011/03
- Substitution of 5-HT1A Receptor Signaling by a Light-activated G Protein-coupled Receptor Eugene Oh,Takashi Maejima,Chen Liu,Evan Deneris,Stefan Herlitze JOURNAL OF BIOLOGICAL CHEMISTRY 285 40 30825 2010/10
- Pet-1 is required across different stages of life to regulate serotonergic function Chen Liu,Takashi Maejima,Steven C. Wyler,Gemma Casadesus,Stefan Herlitze,Evan S. Deneris NATURE NEUROSCIENCE 13 10 1190 2010/10
- ENDOCANNABINOIDS CONTRIBUTE TO METABOTROPIC GLUTAMATE RECEPTOR-MEDIATED INHIBITION OF GABA RELEASE ONTO HIPPOCAMPAL CA3 PYRAMIDAL NEURONS IN AN ISOLATED NEURON/BOUTON PREPARATION H. Inada,T. Maejima,Y. Nakahata,J. Yamaguchi,J. Nabekura,H. Ishibashi NEUROSCIENCE 165 4 1377 2010/02
- Induction of paranodal myelin detachment and sodium channel loss in vivo by Campylobacter jejuni DNA-binding protein from starved cells (C-Dps) in myelinated nerve fibers Hua Piao,Motozumi Minohara,Nobutoshi Kawamura,Wei Li,Yoshimitsu Mizunoe,Fujio Umehara,Yoshinobu Goto,Susumu Kusunoki,Takuya Matsushita,Kazuhiro Ikenaka,Takashi Maejima,Jun-ichi Nabekura,Ryo Yamasaki,Jun-ichi Kira JOURNAL OF THE NEUROLOGICAL SCIENCES 288 1-2 54 2010/01
- Pharmacological evidence for the involvement of diacylglycerol lipase in depolarization-induced endocanabinoid release Yuki Hashimotodani,Takako Ohno-Shosaku,Takashi Maejima,Kiyoko Fukami,Masanobu Kano NEUROPHARMACOLOGY 54 1 58 2008/01
- The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic sites in the hippocampus and cerebellum Y Kawamura,M Fukaya,T Maejima,T Yoshida,E Miura,M Watanabe,T Ohno-Shosaku,M Kano JOURNAL OF NEUROSCIENCE 26 11 2991 2006/03
- Calcium signaling and synaptic modulation: Regulation of endocannabinoid-mediated synaptic modulation by calcium T Ohno-Shosaku,Y Hashimotodani,T Maejima,M Kano CELL CALCIUM 38 3-4 369 2005/09
- Synaptically driven endocannabinoid release requires Ca2+-assisted metabotropic glutamate receptor subtype 1 to phospholipase C beta 4 signaling cascade in the cerebellum T Maejima,S Oka,Y Hashimotodani,T Ohno-Shosaku,A Aiba,DQ Wu,K Waku,T Sugiura,M Kano JOURNAL OF NEUROSCIENCE 25 29 6826 2005/07
- Phospholipase C beta serves as a coincidence detector through its Ca2+ dependency for triggering retrograde endocannabinoid signal Y Hashimotodani,T Ohno-Shosaku,H Tsubokawa,H Ogata,K Emoto,T Maejima,K Araishi,HS Shin,M Kano NEURON 45 2 257 2005/01
- Retrograde modulation of synaptic transmission mediated by endogenous cannabinoids M. Kano,T. Ohno-Shosaku,T. Maejima,T. Yoshida,K. Hashimoto Current Neuropharmacology 2 1 49 2004/01
- Retrograde signaling at central synapses via endogenous cannabinoids M Kano,T Ohno-Shosaku,T Maejima MOLECULAR PSYCHIATRY 7 3 234 2002
- The cannabinoid CB1 receptor mediates retrograde signals for depolarization-induced suppression of inhibition in cerebellar Purkinje cells T Yoshida,K Hashimoto,A Zimmer,T Maejima,K Araishi,M Kano JOURNAL OF NEUROSCIENCE 22 5 1690 2002/03
- Presynaptic inhibition caused by retrograde signal from metabotropic glutamate to cannabinoid receptors T Maejima,K Hashimoto,T Yoshida,A Aiba,M Kano NEURON 31 3 463 2001/08
- Endogenous cannabinoid as a retrograde messenger from depolarized postsynaptic neurons to presynaptic terminals T Maejima,T Ohno-Shosaku,M Kano NEUROSCIENCE RESEARCH 40 3 205 2001/07
- Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals T Ohno-Shosaku,T Maejima,M Kano NEURON 29 3 729 2001/03
Conference Presentations
Others
- Roles of Endocannabinoids in Modulation of Synaptic Transmission KANO Masanobu,HASHIMOTODANI Yuki,MAEJIMA Takashi,OHNO SHOSAKU Takako 47 24 2005/06/02
- Control of synaptic transmission in the CNS through endocannabinoid-mediated retrograde signaling Ohno-Shosaku T,Maejima T,Yoshida T,Hashimoto K,Fukudome Y,Kano M “Dendritic Neurotransmitter Release” edited by Ludwig M. 269 2005
- Endocannabinoid-Mediated Modulation of Excitatory and Inhibitory Synaptic Transmission. Kano, M,Ohno-Shosaku, T,Maejima, T,Yoshida, T "Excitatory-Inhibitory Balance: Synapses, Circuits, and Systems" edited by Hensch, T.K. and Fagiolini, M. 99 2004
- I. Basic Neuroscience 3. カンナビノイド受容体 少作隆子,前島隆司,狩野方伸 Annual Review 神経 2003 18 2003/01/25
- カンナビノイド受容体と逆行性シグナル伝達 前島隆司,少作隆子,狩野方伸 Clin Neurosci 19 12 1431 2001/12/01
- 脳内カンナビノイド受容体とシナプス伝達調節 少作隆子,前島隆司,狩野方伸 脳の科学 23 11 1000 2001/11/10
- 内因性カンナビノイドによる逆行性シナプス伝達調節 少作隆子,前島隆司,水島伊知郎,米田憲秀,狩野方伸 神経化学 40 2/3 440 2001/09/01
- 発達期マウス小脳における代謝型グルタミン酸受容体1型の活性化により誘導されるシナプス前抑制 前島隆司,橋本浩一,吉田隆之,狩野方伸 神経化学 40 2/3 439 2001/09/01
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「中枢時計における概日リズムの行動時間帯を設定する神経回路基盤の解明」(2024-2027)
○「マウス胎盤ラビリンス層に出現する新規GLAST陽性細胞の機能解析」(2022-2024)
○「中枢時計視交叉上核におけるシナプス伝達の機能的性質と役割の解明」(2021-2023)
○「空間認知システムにおける頭部方向情報を処理する神経回路基盤の解明」(2018-2020)
○「錐体オプシンを用いた光遺伝学的手法による睡眠・覚醒制御システム作動機序の解析」(2015-2017)
○「錐体オプシンを用いた光遺伝学的手法による睡眠・覚醒制御システムの解析」(2014-2015)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Basic Human Physiology(2024)
○Neurophysiology 2(2024)
○Neurophysiology 1(2024)
○Neurophysiology(2024)
○Basic Human Physiology(2023)
○Neurophysiology 2(2023)
○Neurophysiology 1(2023)
○Neurophysiology(2023)
○Neurophysiology 1(2022)
○Basic Human Physiology(2022)
○Neurophysiology 2(2022)
○Neurophysiology(2022)
○Neurophysiology(2021)
○Neurophysiology(2020)
○Neurophysiology(2019)
○Neurophysiology(2018)
○Neurophysiology(2017)
Classes (Graduate Schools)
○Molecular Neuroscience and Integrative Physiology(2024)
○Human Body: Functions(2024)
○The Function of the Human Body(2024)
○Molecular Neuroscience and Integrative Physiology(2023)
○Human Body: Functions(2023)
○The Function of the Human Body(2023)
○Frontier Life Science(2022)
○Molecular Neuroscience and Integrative Physiology(2022)
○Human Body: Functions(2022)
○The Function of the Human Body(2022)
○The Function of the Human Body(2021)
○Frontier Life Science(2021)
○The Function of the Human Body(2020)
○Frontier Life Science(2020)
○Molecular Neuroscience and Integrative Physiology(2020)
○Human Body: Functions(2020)
○Molecular Neuroscience and Integrative Physiology(2019)
○Human Body: Functions(2019)
○Frontier Life Science(2019)
○The Function of the Human Body(2019)
○Molecular Neuroscience and Integrative Physiology(2018)
○Human Body: Functions(2018)
○Frontier Life Science(2018)
○The Function of the Human Body(2018)
○Frontier Life Science(2017)
○The Function of the Human Body(2017)
○Molecular Neuroscience and Integrative Physiology(2017)
○Frontier Life Science(2016)
○Molecular Neuroscience and Integrative Physiology(2016)
○The Function of the Human Body(2016)