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Researcher Information

last modified:2024/12/06

Professor FUJINAGA, Yukako

Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field


Laboratory

Academic Background

Career

Year & Month of Birth

Academic Society

Award

Specialities

Speciality Keywords

Research Themes

Books

Papers

  •  Adult-onset botulism in a Japanese woman with prolonged spore excretion Keigo Kihara,Yuta Kajiyama,Yasuyoshi Kimura,Shuhei Okazaki,Naoya Esa,Ryosuke Nobe,Kentaro Shimizu,Kiyoshi Ohno,Daisuke Motooka,Takuhiro Matsumura,Takeshi Shimazu,Shota Nakamura,Yukako Fujinaga,Hideki Mochizuki Journal of Infection and Chemotherapy 29 12 1172 2023/12
  •  Botulinum neurotoxin X lacks potency in mice and in human neurons Brieana M. Gregg,Takuhiro Matsumura,Travis G. Wentz,William H. Tepp,Marite Bradshaw,Pål Stenmark,Eric A. Johnson,Yukako Fujinaga,Sabine Pellett mBio 2024/02/13 
  •  Growth prolongation of human induced pluripotent stem cell aggregate in three-dimensional suspension culture system by addition of botulinum hemagglutinin Riku Yamamoto,Ryo Sakakibara,Mee-Hae Kim,Yukako Fujinaga,Masahiro Kino-oka Journal of Bioscience and Bioengineering 137 2 141 2023/12
  •  Membrane Vesicles Derived From Clostridium botulinum and Related Clostridial Species Induce Innate Immune Responses via MyD88/TRIF Signaling in vitro. Kobayashi N, Abe K, Akagi S, Kitamura M, Shiraishi Y, Yamaguchi A, Yutani M, Amatsu S, Matsumura T, Nomura N, Ozaki N, Obana N, Fujinaga Y. Front Microbiol.  13 720308 2022/02/03
  •  Oral Corticosteroids Impair Mucin Production and Alter the Posttransplantation Microbiota in the Gut. Okafuji H, Iida N, Kitamura K, Seishima J, Wang Z, Yutani M, Yoshio T, Yamashita T, Sakai Y, Honda M, Yamashita T, Fujinaga Y, Shinkura R, Hamaguchi Y, Mizukoshi E, Kaneko S. Digestion 1-18 2022/02/18

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  •  Molecular engineering of a minimal E-cadherin inhibitor protein derived from Clostridium botulinum hemagglutinin. Amatsu S, Matsumura T, Zuka M, Fujinaga Y. .J Biol Chem. 299 3 102944 2023/01/25
  •  Chronic liver disease enables gut Enterococcus faecalis colonization to promote liver carcinogenesis. Iida N, Mizukoshi E, Yamashita T, Yutani M, Seishima J, Wang Z, Arai K, Okada H, Yamashita T, Sakai Y, Masuo Y, Agustina R, Kato Y, Fujinaga Y, Oshima M, Honda M, Lebreton F, Gilmore MS, Kaneko S Nat.Cancer 2 10 1039-1054 2021/09/27
  •  Rare toxin A-negative and toxin B-positive strain of Clostridioides difficile from Japan lacking a complete tcdA gene.  Takemori-Sakai Y, Satou K, Senda Y, Nakamura Y, Otani H, Maekawa A, Oe H, Oshima M, Yoneda-Nakagawa S, Miyagawa T, Sato K, Ogura H, Mori M, Wada T, Sakai Y, Yutani M, Matsumura T, Fujinaga Y, Gabata T, Wada T, Iwata Y. J Infect Chemother. 28 5 651-656 2022/01/22
  •  Effects of antibiotics on the viability of and toxin production by Clostridium botulinum. Yutani M, Matsumura T, Fujinaga Y. Microbiol Immunol. 65 10 432-437 2021/09/08
  •   Functional Analysis of Botulinum Hemagglutinin (HA). Matsumura T, Fujinaga Y*.  Methods Mol. Biol. 2132 191-200 2020
  •  Botulinum Hemagglutinin: Critical Protein for Adhesion and Absorption of Neurotoxin Complex in Host Intestine. Amatsu S, Fujinaga Y* 2132 183-190 2020
  •  Fully Human Monoclonal Antibodies Effectively Neutralizing Botulinum Neurotoxin Serotype B Matsumura T, Amatsu S, Misaki R, Yutani M, Du A, Kohda T, Fujiyama K, Ikuta K, Fujinaga Y* Toxins 12 E302 2020
  •  Gut-derived Enterococcus faecium from ulcerative colitis patients promotes colitis in a genetically susceptible mouse host.  Seishima J, Iida N, Kitamura K, Yutani M, Wang Z, Seki A, Yamashita T, Sakai Y, Honda M, Yamashita T, Kagaya T, Shirota Y, Fujinaga Y, Mizukoshi E, Kaneko S. Genome Biol. 20 1 252 2019/11/25
  •  Collagen adhesion gene is associated with bloodstream infections caused by methicillin-resistant Staphylococcus aureus. Iwata Y, Satou K, Furuichi K, Yoneda I, Matsumura T, Yutani M, Fujinaga Y, Hase A, Morita H, Ohta T, Senda Y, Sakai-Takemori Y, Wada T, Fujita S, Miyake T, Yasuda H, Sakai N, Kitajima S, Toyama T, Shinozaki Y, Sagara A, Miyagawa T, Hara A, Shimizu M, Kamikawa Y, Ikeo K, Shichino S, Ueha S, Nakajima T, Matsushima K, Kaneko S, Wada T.  Int J Infect Dis  91 22 2020/02/01
  •  Maintenance of an undifferentiated state of human-induced pluripotent stem cells through botulinum hemagglutinin-mediated regulation of cell behavior.  Shuzui E, Kim MH, Azuma K, Fujinaga Y, Kino-Oka M. J Biosci Bioeng 127 6 744 2019/06/01
  •  A Simple and Robust Method for Culturing Human-Induced Pluripotent Stem Cells in an Undifferentiated State Using Botulinum Hemagglutinin. Kim MH, Matsubara Y, Fujinaga Y, Kino-Oka M. Biotechnol J. 13 2 2018/02/01
  •  Translocation and dissemination of botulinum neurotoxin from the intestinal tract. Fujinaga Y, Popoff MR. Toxicon S0041-1010 17 30324-0 2017/10/01
  •  Multivalency effects of hemagglutinin component of type B botulinum neurotoxin complex on epithelial barrier disruption. Amatsu S, Matsumura T, Yutani M, Fujinaga Y. Microbiol Immunol.  62 2 80-89 2018/02/01
  •   Botulinum hemagglutinin-mediated selective removal of cells deviating from the undifferentiated state in hiPSC colonies. Kim MH, Sugawara Y, Fujinaga Y, Kino-oka M Scientific Reports 7 93 2017/03/01

Conference Presentations

  • Endogenous production and neurotoxicity of novel botulinum neurotoxin (BoNT/X) in a clinical isolate(2023/03/16)
  • Development of genetic manipulation methods for group I Clostridium botulinum. (conference:Interagency Botulinum Research Coordinating Committee)(2022/10/17)
  • New insights into the pathobiology of Clostridium botulinum enteric infection (conference:The 15th Korea-Japan International Symposium on Microbiology)(2022/10/13)
  • New insights into the pathobiology of Clostridium botulinum enteric infection(conference:The 20th Awaji International Forum on Infection and Immunity)(2022/09/07)
  • Mechanisms of intestinal absorption of botulinum neurotoxin complex.(conference:Toxins 2017)(2017/01/19)

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  • Intestinal absorption mechanism of type B1 botulinum progenitor toxin produced by strain Okra.(conference:54th Interagency Botulism Research Coordinating Committee(IBRCC))(2017/10/22)
  • E-cadherin機能阻害活性を維持した最小化ボツリヌス菌ヘマグルチニン由来物質の開発(conference:第65回トキシンシンポジウム)(2018/07/11)
  • Therapeutic and preventive effect of fully human monoclonal antibodies against type B botulinum intoxication.(conference:55th Interagency Botulism Research Coordinating Committee(IBRCC))(2018/10/24)
  • Human-Derived monoclonal antibodies effectively neutralize botulinum neurotoxin.(conference:TOXINS 2019)(2019/01/16)
  • Mechanism of pathogenesis of botulinum neurotoxin complex and its application. (conference:CLOSTPATH 11)(2019/08/19)
  • Molecular engineering of Nano-HA, a minimal protein that inhibits E-cadherin-mediated cell-cell adhesion derived from Clostridium botulinum hemagglutinin.(conference:56th IBRCC 2019)(2019/10/27)
  • New insights on the pathophysiology of intestinal Clostridium botulinum infection : Learning from intestinal botulism. (conference:World Microbe Forum 2021)(2021/06/14)
  • Clostridium botulinum enteric infections: Novel insights into the interplay between C. botulinum and gut microbiota (2022/02/04)

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Medical Bacteriology(2019)
○Medical Bacteriology(2018)
○Medical Bacteriology(2017)
○Medical Bacteriology(2016)

Classes (Graduate Schools)

○Basic Training on Medical Researches(2019)
○Intensive Lectures on Medical Researches(2019)
○Bacterial Infections(2019)
○Medical Sciences(2019)
○Bacterial Infections(2019)
○The Human Body in Health and Disease Curriculum 1(2019)
○The Human Body in Health and Disease Curriculum 1(2019)
○Bacterial Infections(2018)
○Bacterial Infections(2018)
○Bacterial Infections(2018)
○Bacterial Infections(2017)
○Bacterial Infections(2017)
○Bacterial Infections(2017)
○Introduction to Basic Medical Science(2016)
○Bacterial Infections(2016)
○Bacterial Infections(2016)
○Bacterial Infections(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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