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Researcher Information

last modified:2024/03/21

Assistant Professor ISHIMOTO, Takahiro

Faculty, Affiliation

Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field


Academic Background


Kanazawa University Assistant professor(2019/03-)
Burke Neurological Institute Postdoctoral fellow(2018/10-2019/02)
Cincinnati Children's Hospital Medical Center Postdoctoral fellow(2018/04-2018/09)

Year & Month of Birth

Academic Society

American Society for Pharmacology and Experimental Therapeutics (ASPET)



○Young Investigator Award(2024/02/17)
○ASPET 2023, Presentation Award (2nd place) (2023/05)
○ASPET 2023, Travel Award(2023/03)
○Overseas postdoctoral fellowships, the Uehara Memorial Foundation(2018/03)



Speciality Keywords

Research Themes



  •  Ergothioneine promotes longevity and healthy aging in male mice. Katsube M, Ishimoto T, Fukushima Y, Kagami A, Shuto T, Kato Y. Geroscience 2024/03/06
  •  TrkB phosphorylation in serum extracellular vesicles correlates with cognitive function enhanced by ergothioneine in humans. Ishimoto T, Yamashita R, Matsumoto R, Matsumoto S, Matsuo Y, Nakao S, Masuo Y, Suzuki M, Kato Y. npj Science of Food 8 1 11 2024/02/06
  •  Ergothioneine in the brain Ishimoto T, Kato Y FEBS Letters 2022
  •  Regulation of Neurogenesis by Organic Cation Transporters: Potential Therapeutic Implications Ishimoto T, Kato Y Handbook of Experimental Pharmacology 2021
  •  Ergothioneine-induced Neuronal Differentiation is Mediated through Activation of S6K1 and Neurotrophin 5-TrkB Signaling in Murine Neural Stem Cells.  Ishimoto T, Masuo Y, Kato Y, Nakamichi N Cellular Signalling 2019/01

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  •  Carnitine/Organic Cation Transporter OCTN1 Negatively Regulates Activation in Murine Cultured Microglial Cells.  Ishimoto T, Nakamichi N, Nishijima H, Masuo Y, Kato Y Neurochemical Research 2018/01
  •  Food-derived antioxidant ergothioneine improves sleep difficulties in humans  Makoto Katsube, Hiroshi Watanabe, Kosuke Suzuki, Takahiro Ishimoto, Yoshitaka Tatebayashi, Yukio Kato, Norihito Murayama Journal of Functional Foods 2022/08
  •  Oral Administration of the Food Derived Hydrophilic Antioxidant Ergothioneine Enhances Object Recognition Memory in Mice Nakamichi N, Nakao S, Nishiyama M, Takeda Y, Ishimoto T, Masuo Y, Matsumoto S, Suzuki M, Kato Y Current Molecular Pharmacology 2021
  •  Identification of Food-derived Isoflavone Sulfates as Inhibition Markers for Intestinal Breast Cancer Resistance Proteins. Agustina R, Masuo Y, Kido Y, Shinoda K, Ishimoto T, Kato Y Drug Metabolism & Disposition 2021
  •  Adeno-associated virus-mediated knockdown demonstrates the major role of hepatic Bcrp in the overall disposition of the active metabolite of the tyrosine kinase inhibitor regorafenib in mice Aya Hasan Alshammari, Yusuke Masuo, Shotaro Yoshino, Reiya Ymashita, Takahiro Ishimoto, Ken-ichi Fujita, Yukio Kato Drug Metabolism and Pharmacokinetics 2022/11
  •  Homostachydrine is a Xenobiotic Substrate of OCTN1/SLC22A4 and Potentially Sensitizes Pentylenetetrazole-Induced Seizures in Mice. Nishiyama M, Nakamichi N, Yoshimura T, Masuo Y, Komori T, Ishimoto T, Matsuo JI, Kato Y Neurochemical Research 2020
  •  Maturational Characterization of Mouse Cortical Neurons Three-Dimensionally Cultured in Functional Polymer FP001-Containing Medium. Nakamichi N, Matsumoto Y, Kawanishi T, Ishimoto T, Masuo Y, Horikawa M, Kato Y Biological and Pharmaceutical Bulletin 2019
  •  Screening to Identify Multidrug Resistance-Associated Protein Inhibitors with Neuroblastoma-Selective Cytotoxicity. Nakamichi N, Ishimoto T, Yamauchi Y, Masuo Y, Kato Y Biological and Pharmaceutical Bulletin 2016
  •  Food-derived hydrophilic antioxidant ergothioneine is distributed to the brain and exerts antidepressant effect in mice.  Nakamichi N, Nakayama K, Ishimoto T, Masuo Y, Wakayama T, Sekiguchi H, Sutoh K, Usumi K, Iseki S, Kato Y Brain and Behavior 2016/04
  •  Gene ablation of carnitine/organic cation transporter 1 reduces gastrointestinal absorption of 5-aminosalicylate in mice.  Shimizu T, Kijima A, Masuo Y, Ishimoto T, Sugiura T, Takahashi S, Nakamichi N, Kato Y Biological and Pharmaceutical Bulletin 2015
  •  Organic cation transporter-mediated ergothioneine uptake in mouse neural progenitor cells suppresses proliferation and promotes differentiation into neurons.  Ishimoto T, Nakamichi N, Hosotani H, Masuo Y, Sugiura T, Kato Y PLoS One 2014/02
  •  Involvement of carnitine/organic cation transporter OCTN1/SLC22A4 in gastrointestinal absorption of metformin. Nakamichi N, Shima H, Asano S, Ishimoto T, Sugiura T, Matsubara K, Kusuhara H, Sugiyama Y, Sai Y, Miyamoto K, Tsuji A, Kato Y Journal of Pharmaceutical Sciences 2013/09

Conference Presentations

  • Involvement of Organic Cation Transporter OCTN1/SLC22A4 in Neurogenesis: a Potential Preventive Target for Neurodegenerative Diseases(conference:2023 ICCP450/JSSX)(2023/09/25)
  • Effect of Inhibition of Xenobiotic Transporter MRP5/ABCC5 on Neurite Elongation: Screening for MRP5 Inhibitors among Clinically Used Drugs(conference:ASPET 2023)(2023/05/18)
  • Inhibition of amino acid transporter suppresses activation of microglial cell lines.(conference:第97回日本薬理学会)(2023/12/14)
  • Signaling pathway for proliferation effect of tri-deoxycytidine in neural stem cells.(2022/03/08)
  • Effect of intravenously administered adeno-associated virus encoding TrkB gene on hippocampal neurogenesis.(2022/03/08)

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  • Functional expression and inhibition by clinically used drugs of efflux transporter MRP5/ABCC5 in neuronal cells.(2021/09/30)
  • Proteomics analysis of trideoxycytidine-induced proliferation of neural stem cells.(2021/09/30)
  • Amount of phosphorylated TrkB in serum extracellular vesicles reflect ergothioneine-induced enhancement of cognitive function(2021/03/26)
  • Oral administration of food-derived amino acid ergothioneine enhances learning and memory by phosphorylation of TrkB and promotion of neurogenesis in the hippocampal dentate gyrus(2021/03/08)
  • Proliferative effect of tri-deoxyribonucleotides on mouse neural stem cells(2021/03/08)
  • Transporter-mediated Ergothioneine Uptake Promotes Neuronal Differentiation through Activating NT5/TrkB/mTORC1 Signaling in Neural Stem Cells(conference:New Frontier in Neuroscience)(2020/01/09)
  • Enhancement of Neurogenesis by OCTN1-mediated Ergothioneine Transport(conference:APSTJ Global Education Seminar)(2019/09/30)
  • Functional Expression of Xenobiotic Transporters in Neural Stem Cells(conference:The 3rd Workshop for Japan-Korea Young Scientists on Pharmaceutics)(2019/07/10)


Arts and Fieldwork


Theme to the desired joint research

Grant-in-Aid for Scientific Research


Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Experiments in Pharmaceutical Practice 3(2023)
○Experiments in Pharmaceutical Practice 3(2023)

Classes (Graduate Schools)

International Project

International Students

Lecture themes

Others (Social Activities)

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