Specialities

Bacteriology (including mycology)、Immunology、Molecular biology

Speciality Keywords

Clostridium botulinum, Intestinal microbiota, Microfold cell, mucosal immunology, membrane vesicles, organoid

Research Themes

Books

Papers

• 　Membrane Vesicles Derived From Clostridium botulinum and Related Clostridial Species Induce Innate Immune Responses via MyD88/TRIF Signaling in vitro 　Nobuhide Kobayashi, Kimihiro Abe, Sachiyo Akagi, Mayu Kitamura, Yoshitake Shiraishi, Aki Yamaguchi, Masahiro Yutani, Sho Amatsu, Takuhiro Matsumura, Nobuhiko Nomura, Noriyuki Ozaki, Nozomu Obana, Yukako Fujinaga　Frontiers in Microbiology　13　2022/02/03　
• 　Osteoprotegerin-dependent M-cell self-regulation balances gut infection and immunity.　Kimura S, Nakamura Y, Kobayashi N, Shiroguchi N, Kawakami E, Mutoh M, Takahashi-Iwanaga H, Yamada T, Hisamoto M, Nakamura M, Udagawa N, Sato S, Kaisho T, Iwanaga T, and Hase K　Nature communications　11　1　234　2020　
• 　The Roles of Peyer’s Patches and Microfold Cells in the Gut Immune System: Relevance to Autoimmune Diseases.　Kobayashi, N., Takahashi, D., Takano, S., Kimura, S. & Hase, K.　Frontiers in Immunology　10　2345　2019
• 　Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses.　Nagai, M., Noguchi, R., Takahashi, D., Morikawa, T., Koshida, K., Komiyama, S., Ishihara, N., Yamada, T., Kawamura, Y., Muroi, K., Hattori, K., Kobayashi, N., Fujimura, Y., Hirota, M., Matsumoto, R., Aoki, R., Tamura-Nakano, M., Sugiyama, M., Katakai, T., Sato, S., Takubo, K., Dohi, T. & Hase, K.　Cell　178　5　1072-1087　2019
• 　Sox8 is essential for M-cell maturation to accelerate IgA response at the early stage after weaning in mice.　#Kimura S., #Kobayashi N. (#equal first contribution), Nakamura Y, Kanaya T, Takahashi D, Fujiki R, Mutoh M, Obata Y, Iwanaga T, Nakagawa T, Kato N, Sato S, Kaisho T, Ohno H, Hase K　Journal of Experimental Medicine　216　4　831-846　2019

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Conference Presentations

• C. botulinum and related clostridia derived membrane vesicles induce inflammatory responses.(2022/03/29)
• Analysis of host response against membrane vesicles derived from Clostridium botulinum.(conference：The Interagency Botulism Research Coordinating Committee)(2021/10/25)
• Analysis of the interaction between host and Clostridium botulinum derived membrane vesicles.(conference：The 93rd Annual Meeting of Japanese Society for Bacteriology.)(2020/02/19)
• Sox8 is essential for the maturation of M cells and accelerates IgA response at the early stage after weaning.(conference：The 18th Awaji International Forum on Infection and Immunity)(2019/09/12)
• Sox8 is essential for M-cell maturation to accelerate IgA response in the gut.(conference：19th international congress of mucosal immunology)(2019/07/19)

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「共生細菌による病原性クロストリジウム属菌の腸管感染制御とその機構の解明」(2024-2026)　
○「腸内細菌叢が産生する膜小胞が腸管恒常性維持に果たす役割の解明」(2022-2024)　
○2021「ボツリヌス菌が産生する膜小胞の病態生理学的意義の解明」(2020-2021)　
○「腸管感染型ボツリヌス症を制御する腸内因子のin vivoを中心とした解析」(2021-2023)　
○「M細胞の抗原取り込みにおける新規同定輸送関連分子による制御機構の解明」(2019-2020)　

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

Classes (Graduate Schools)