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Researcher Information

last modified:2020/03/31

Professor Goto, Noriko

Mail Laboratory Website
Laboratory Website
Laboratory Website

Faculty, Affiliation

Cancer Research Institute

College and School Educational Field

Division of Natural Sciences, Graduate School of Natural Science and Technology
Division of Medical Science, Graduate School of Medical Science
Division of Natural System, Graduate School of Natural Science and Technology

Laboratory

 TEL:076-264-6731

Academic Background

Career

Year & Month of Birth

Academic Society







Award

Specialities

Pathological medical chemistry、Tumor biology

Speciality Keywords

caner stem cell, tumor microenvironment, breast cancer, lung cancer, signal transduction, receptor tyrosine kinase, adaptor protein, molecular target, patient-derived xenograft (PDX), cancer mouse model

Research Themes

Books

  •  Gotoh, N Encyclopedia of Signaling Molecules, 2rd Edition Springer 2017
  •  Gotoh N and Tsuchida N Encyclopedia of Cancer, 3rd Edition Springer 2016

Papers

  •  Drug resistant mechanisms of cancer stem-like cells and their therapeutic potential as drug targets Murayama T, Gotoh N Cancer Drug Resist 2 457-470 2019
  •  Feedback inhibitors of epidermal growth factor receptor signaling pathways Gotoh, N Int. J. Biochem. Cell Biol. 41 511-515 2009
  •  Patient-derived xenograft models of breast cancer and their application. Murayama T, Gotoh N Cells 8 6 E621 2019
  •  Elucidation of breast cancer tissue diversity by comprehensive analysis of minimum unit omics.  Gotoh N. Impact, 2019 3 30-32 2019
  •  Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells. Tominaga K, Minato H, Murayama T, Sasahara A, Nishimura T, Kiyokawa E, Kanauchi H, Shimizu S, Sato A, Nishioka K, Tsuji E, Yano M, Ogawa T, Ishii H, Mori M, Akashi K, Okamoto K, Tanabe M, Tada K, Tojo A, Gotoh N Proc Natl Acad Sci, USA 116 2 625-630 2019

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  •  Cancer stem-like properties and gefitinib-resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2 Nishimura T, Nakata A, Chen X, Nishi K, Meguro-Horike M, Sasaki S, Kita K, Horike S-I, Saitoh K, Kato K, Igarashi K, Murayama T, Kohno S, Takahashi C, Mukaida N, Yano S, Soga T, Tojo A, Gotoh N Oncogene, 38 14 2464-2481 2019
  •  Polyamine flux suppresses histone lysine demethylases and enhances ID1 gene expression in cancer stem cells.  Tamari K, Konno M, Asai A, Koseki J, Hayashi K, Kawamoto K, Murai N, Matsufuji S, Isohashi F, Satoh T, Goto N, Tanaka S, Doki Y, Mori M, Ogawa K, Ishii H Cell Death Diifer 4 1-9 2018
  •  Drug discovery of anti-cancer drugs targeting methylenetetrahydrofolage dehydrogenease 2.  Asai A, Koseki J, Konno M, Nishimura T, Gotoh N, Satoh T, Doki Y, Mori M, Ishii H Helion 4 e01021 2018
  •  Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis Garg A, Bansal M, Gotoh N, Feng G-S, Zhong J, Wang F, Kariminejad A, Brooks S, Zhang X. PLoS Genet, 13 e1007047 2017
  •  Intratumoral bidirectional transitions between epithelial and mesenchymal cells in triple-negative breast cancer Yamamoto M, Sakane K, Tominaga K, Gotoh N, Niwa T, Kikuchi Y, Tada K, Goshima N, Semba K, Inoue J-I Cancer Sci, 108 1210-1222 2017
  •  The RB-IL-6 axis controls self-renewal and endocrine therapy resistance by fine-tuning mitochondrial activity.  Kitajima S, Yoshida A, Kohno S, Suzuki S, Nagatani N, Li F, Nishimoto Y, Sasaki N, Muranaka H, Wan Y, Thai T, Okahashi N, Matsuda F, Shimizu H, Nishiuchi T, Suzuki Y, Tominaga K, Gotoh N, Suzuki M, Ewen M, Barbie D, Hirose O, Tanaka T, Takahashi C Oncogene, 26 5145-5157 2017
  •  FRS2 Gotoh, N Encyclopedia of Signaling Molecules, 2rd Edition 2017
  •  An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cells. Sasahara A, Tominga K, Nishimura T,Yano M, Kiyokawa E, Noguchi Miki, Noguchi Masakuni, Kanauchi H, Ogawa T, Minato H, Tada K, Seto Y, Tojo A, Gotoh N Oncotarget, 8 24869-24881 2017
  •  Long-term inflammation transforms intestinal epithelial cells of colonic organoids Hibiya S, Tsuchiya K, Hayashi R, Fukushima K, Horita N, Nishimura T, Gotoh N, Okamoto R, Nakamura T and Watanabe M J Crohns Colitis 11 621-630 2017
  •  Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells.  Tominaga K, Shimamura T, Kimura N, Murayama T, Matsubara D, Kanauchi H, Niida A, Shimizu S, Nishioka K, Tsuji E, Yano M, Sugano S, Shimono Y, Ishii H, Saya H, Mori M, Akashi K, Tada K, Ogawa T, Tojo A, Miyano S, Gotoh N. Oncogene, 36 1276-1286 2017
  •  Metabolic Adaptation to Nutritional Stress in Human Colorectal Cancer Miyo M, Konno M, Nishida N, Sueda T, Noguchi K, Matsui H, Colvin H, Kawamoto K, Koseki J, Haraguchi N, Nishimura J, Hata T, Gotoh N, Matsuda F, Satoh T, Mizushima T, Shimizu H, Doki Y, Mori M, Ishii H Sci Rep, 6 38415 2016
  •  Intrinsic resistance to 5-Fluorouracil in a brain metastatic variant of human breast cancer cell line, MDA-MB-231BR Sagara A, Igarashi K, Otsuka M, Karasawa T, Gotoh N, Narita M, Kuzumaki N, Narita M, Kato Y PLoS One, 11 e0164250 2016
  •  Intra-bone fibroblasts promote breast cancer bone metastasis by producing connective tissue growth factor/CCN2 under the influence of cancer cell-derived chemokine, CCL4 Sasaki S, Baba T, Nishimura T, Hayakawa Y, Hashimoto S, Gotoh N, Mukaida N Cancer Lett, 378 23-32 2016
  •  Oncogenic fusion gene CD74-NRG1 confers cancer stem cell-like properties in lung cancer through a IGF2 autocrine/paracrine circuit, Murayama T, Nakaoku T, Enari T, Nishimura T, Tominaga K, Nakata A, Tojo A, Sugano S, Kohno T, Gotoh N Cancer Res. 76 974-983 2016
  •  Membrane-linked docking protein Gotoh N and Tsuchida N Encyclopedia of Cancer, 3rd Edition 2016
  •  Cyclin G2: A novel independent prognostic marker in pancreatic cancer.  Hasegawa S, Nagano H, Konno M, Eguchi H, Tomokuni A, Tomimaru Y, Wada H, Hama N, Kawamoto K, Kobayashi S, Marubashi S, Nishida N, Koseki J, Gotoh N, Ohno S, Yabuta N, Nojima H, Mori M, Doki Y, Ishii H Oncol Lett, 10 2986-2990 2015
  •  Pyruvate Kinase M2, but not M1, allele maintains immature metabolic states of murine embryonic stem cells Konno M, Ishii H, Koseki J, Tanuma N, Nishida N, Kawamoto K, Nishimura T, Nakata A, Matsui H, Noguchi K, Ozaki M, Noguchi Y, Shima H, Gotoh N, Nagano H, Doki Y, Mori M Regenerative Therap 1 63-71 2015
  •  A novel serum 4-microRNA signature for lung cancer detection. Nadal E, Truini A, Nakata A, Lin J, Reddy RM, Chang A, Ramnath N, Gotoh N, Beer DG, Chen G: Sci Rep 5 12464 2015
  •  Embryonic MicroRNA-369 controls metabolic splicing factors and urges cellular reprogramming Konno M, Koseki J, Kawamoto K, Nishida N, Matsui H, Dewi DL, Ozaki M, Noguchi Y, Mimori K, Gotoh N, Tanuma N, Shima H, Doki Y, Mori M, Ishii H PLoS One, 10 e0132789 2015
  •  Reprogramming and Suppress Malignant Phenotypes of Human Colon Cancer Cells.  Ogawa H, Wu X, Kawamoto K, Nishida N, Konno M, Koseki J, Matsui H, Noguchi K, Gotoh N, Yamamoto T, Miyata K, Nishiyama N, Nagano H, Yamamoto H, Obika S, Kataoka K, Doki Y, Mori M, Ishii H PLoS One, 10 e0127119 2015
  •  MicroRNA-1246 expression associated with CCNG2-mediated chemoresistance and stemness in pancreatic cancer Hasegawa S, Eguchi H, Nagano H, Konno M, Tomimaru Y, Wada H, Hama N, Kawamoto K, Kobayashi S, Nishida N, Koseki J, Nishimura T, Gotoh N, Ohno S, Yabuta N, Nojima H, Mori M, Doki Y, Ishii H. Br J Cancer, 111 1572-80 2014
  •  Epiregulin enhances tumorigenicity activating ERK/MAPK pathway in glioblastoma Kohsaka S, Hinohara K, Wang L, Nishimura T, Urushido M, Yachi K, Tsuda M, Tanino M, Kimura T, Nishihara H, Gotoh N, Tanaka S Neuro. Oncol 16 960-70 2014
  •  FGFR1-Frs2/3 signalling maintains sensory progenitors during inner ear hair cell formation. Ono K, Kita T, Sato S, O’Neill P, Mak S-S., Paschaki M, It, M, Gotoh, N, Kawakami K, Ladher RK PLOS Genetics 10 e1004118 2014
  •  Frs2alpha and Shp2 signal independently of Gab to mediate FGF signaling in lens development Li H, Ta, C, Cai Z., Hertzler-Schaefer K, Collins TN, Wang F, Feng G-S, Gotoh N, Zhang X J. Cell Sci 127 571-582 2014
  •  The ordered acquisition of Class II and Class I mutations directs formation of human t(8;21) acute myelogenous leukemia stem cell. Shima T, Miyamoto T, Kikushige Y, Yoda J, Tochigi T, Yoshimoto G, Kato K, Takenaka K, Iwasaki H, Mizuno S, Goto N, Akashi K. Exp Hematol,  42 955-965, 2014
  •  Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition Hamabe A, Konno M, Tanuma N, Shima H, Tsunekuni K, Kawamoto K, Nishida N, Koseki J, Mimori K, Gotoh N, Yamamoto H, Doki Y, Mori M, Ishii H Proc. Natl. Acad. Sci., USA 111 15526-31 2014
  •  Effect of in vivo administration of reprogramming factors in the mouse liver. Tomokuni A, Eguchi H, Hoshino H, Dewi DL, Nishikawa S, Kano Y, Miyoshi N, Tojo A, Kobayashi S, Gotoh N, Hinohara K, Fusaki N, Saito T, Suemizu H, Wada H, Kobayashi S, Marubashji S, Tanemura M, Doki Y, Mor, M, Ishii H, Nagano H Oncol. Lett. 6 323-328 2013
  •  Protooncogene TCL1b functions as an Akt kinase co-activator which exhibits oncogenic potency in vivo Hashimoto M, Suizu F, Tokuyama W., Noguchi H, Hirata N, Matsuda-Lennikov M, Masuzawa M, Gotoh, N, Tanaka S. & Noguchi M Oncogenesis 2 e70 2013
  •  Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma. Cai Z, Tao C, Li H, Ladher R, Gotoh N, Feng GS, Wang F. & Zhang X Development, 140 2711-2723 2013
  •  An adaptor protein complex of FRS2beta and CIN85/CD2AP provides a novel mechanism for ErbB2/HER2 protein downregulation. Minegishi Y, Shibagaki Y, Mizutani A, Fujita F, Tezuka T, Kinoshita M, Kuroda M, Hattori S. & Gotoh N Cancer Sci. 104 345-352 2013
  •  Elevated beta-catenin pathway as a novel target for patients with resistance to EGF receptor targeting drugs Nakata A, Yoshida R, Yamaguchi R, Yamauchi M, Tamada Y, Fujita A, Shimamura T, Imoto S, Higuchi T, Nomura M, Kimura T, Nokihara H, Higashiyama K, Kondoh K, Nishihara H, Tojo A, Yano S, Miyano S, Gotoh N. Sci Rep 5 13076 2015
  •  Growth factor signaling regulates breast cancer stem cells. In Practical molecular target for suppression of cancer Gotoh N Publication in Forum on Immunopathological Diseases and Therapeutics 4 2013
  •  The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein Kano Y, Tsuchiya K, Zheng X, Horita N, Fukushima K, Hibiya S, Yamauchi Y, Nishimura T, Hinohara K, Gotoh N, Suzuki S, Okamoto R., Nakamura T. & Watanabe M Biochem. Biophys. Res. Commun 432 175-181 2013
  •  Systemically injected exosomes targeted to EGFR deliver anti-tumor microRNA to breast cancer cells. Ohno, S., Takanashi, M., Sudo, K., Ueda, S., Ishikawa, A, Matsuyama, N., Fujita, K., Mizutani, T., Ohgi, T., Ochiya, T., Gotoh, N. & Kuroda, M. Molecular Therapy 21 185-191 2012
  •  EGFR-targeted liposome for molecular imaging and therapy on NSCLC cells.  Yokoyama T, Osato Y, Miyazawa K, Kiyasato A, Hayabe H, Nomura M, Gotoh N, Itoi T, Tauchi T, Ikeda N & Ohyashiki K Cancer Res. 72 2904 2012
  •  Epidermal growth factor receptor tyrosine kinase defines critical prognostic genes of stage I lung adenocarcinoma Yamauchi, M., Yamaguchi, R., Nakata, A., Kohno, T., Nagasaki, M., Shimamura, T., Imoto S., Saito A., Ueno, K., Hatanaka, Y., Yoshida, R., Higuchi, T., Nomura, M., Beer, D.G., Yokota, J., Miyano, S. & Gotoh, N PLoS ONE, 7 e43923 2012
  •  Recent understanding of the molecular mechanisms for the efficacy and resistance of EGF receptor-specific tyrosine kinase inhibitors in non-small cell lung cancer. Nakata, A. & Gotoh, N. Expert Opin. Ther. Targets 16 771-781 2012
  •  ErbB/NF-kB signaling controls mammosphere formation in human breast cancer. Hinorara K, Kobayashi S, Kanauchi H, Shimizu S, Nishioka K, Tsuji E, Tada K, Umezawa K, Mori M, Ogawa T, Inoue J, Tojo A. & Gotoh N Proc. Natl. Acad. Sci., USA 109 6584-6589 2012
  •  Identifying regulational alterations in gene regulatory networks by state space representation of vector autoregressive models and variational annealing. Kojima, K., Imoto, S., Yamaguchi, R., Fujita, A., Yamauchi, M., Gotoh, N. & Miyano, S BMC Genomics suppl 1 S6 2012
  •  Identification of genes up-regulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinoma Okayama, H., Khono, T., Ishii, Y., Shimada, Y., Shiraishi, K., Iwakawa, R., Furuta, K., Tsuta, K., Shibata, T., Yamamoto, S., Watanabe, S., Sakamoto, H., Kumamoto, K., Takenoshita, S., Gotoh, N., Mizuno, H., Sarai, A., Kawano, S., Yamaguchi, R., Miyano, S. & Yokota, J Cancer Res. 72 100-111 2012
  •  Integrated quantitative analysis of the phoshpoproteome and transcriptome in tamoxifen-resistant breast cancer. Oyama, M., Nagashima, T., Suzuki, T., Kozuka-Hata, H., Yumoto, N., Shiraishi, Y., Ikeda, K., Kuroki, Y., Gotoh, N., Ishida, T., Inoue, S., Kitano, H. & Okada-Hatakeyama, M J. Biol. Chem 286 818-829 2011
  •  Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. Nomura, M., Fukuda, T, Fujii, K., Kawamura, T., Tojo, H., Kihara, M., Bando, Y., Gazdar, A.F., Tsuboi, M., Oshiro, H., Nagao, T., Ohira, T., Ikeda, N., Gotoh, N., Kato, H., Marko-Varga, G. & Nishimura, T Journal of Clinical Bioinformatics, 1 23 2011
  •  N-cadherin expression is a potential survival mechanism of gefitinib-resistant lung cancer cells. Yamauchi, M., Yoshino, I., Yamaguchi, R., Shimamura, T., Nagasaki, M., Imoto, S., Niida, A., Koizumi, F., Kohno, T., Yokota, J., Miyano, S. & Gotoh, N Am. J. Cancer. Res 1 823-833 2011
  •  Somatic mutations of the EGF receptor and their signal transducers affect the efficacy of EGF receptor-specific tyrosine kinase inhibitors Gotoh, N. Int. J. Clin. Exp. Pathol 4 403-409 2011
  •  FRS2 Gotoh, N Encyclopedia of Signaling Molecule 2011
  •  Phosphoproteomics-based modeling defines the regulatory mechanism underlying aberrant EGFR signaling Tasaki, S., Nagasaki, M., Kozuka-Hata, H., Semba, K., Gotoh, N., Hattori, S., Inoue, J., Yamamoto, T., Miyano, S., Sugano, S. and Oyama, M PLoS ONE, 5 11 e13926 2010
  •  Possible signaling pathways in cancer stem cells in breast cancer. Gotoh, N Cancer Stem Cells Theories and Practice, chapter 13 2011
  •  Inflammatory signaling pathways in self-renewing breast cancer stem cells. Hinohara, K. and Gotoh, N Curr. Opin. Pharmacol 10 650-654 2010
  •  Collocation-based sparse estimation for constructing dynamic gene networks. Shimamura, T., Imoto, S., Nagasaki, M., Yamauchi, M., Yamaguchi, R., Fujita, A., Tamada, Y., Gotoh, N., Miyano, S Genome Inform 24 164-178 2010
  •  FGF-FRS2alpha-Erk axis controls a self-renewal target Hes1 and growth of neural stem/progenitor cells Sato, T., Shimazaki, T., Naka, H, Fukami, S., Okano, H., Lax, I., Schlessinger, J. and Gotoh, N. Stem Cells 28 1661-1672 2010
  •  FRS2beta a potential prognostic gene for non-small cell lung cancer, encodes a feedback inhibitor for EGF receptor family members via ERK binding.  Iejima, D., Minegichi, Y., Takenaka, K., Siswanto, A., Watanabe, M., Huang, L., Watanabe, T., Tanaka, F., Kuroda, M. and Gotoh, N Oncogene 29 3087-3099 2010
  •  A state space representation of VAR models with sparse learning for dynamic gene networks. Kojima, K., Yamaguchi, R., Imoto, S., Yamauchi, M., Nagasaki, M., Yoshida, R., Shimamura, T, Ueno, K., Higuchi, T., , Gotoh, N., Miyano, S Genome Inform 22 56-68 2010
  •  Gene set enrichment analysis provides insight into novel signaling pathways in breast cancer stem cells Murohashi, M., Hinohara, K., Kuroda, M., Isagawa, T., Tsuji, S., Kobayashi, S., Umezawa, K., Tojo, A., Aburatani, H. and Gotoh, N Br J. Cancer 102 206-212 2010
  •  An FGF4-FRS2alpha-Cdx2 axis-in trophoblast stem cells induces BMP4 to regulate proper growth of early mouse embryos Murohashi, M., Nakamura, T., Tanaka, S., Ichise, T., Yoshida, N., Yamamoto, T., Shibuya, M., Schlessinger, J. and Gotoh, N Stem Cells 28 113-121 2010
  •  Gain-of-function of mutated c-Cbl tumor suppressor in myeloid neoplasms with 11q uniparental disomy Sanada, M., Suzuki, T., Shih, L.-Y., Otsu, M., Kato, M., Yamazaki, S., Tamura, A., Honda, H., Sakata-Yanagimoto, M., Kumano, K., Oda, H., Yamagata, T., Takita, J., Gotoh, N., Nakazaki, K., Kawamata, N., Onodera, M., Nobuyoshi, M., Hayashi, Y., Harada, H., Kurokawa, M., Chiba, S., Mori, H., Ozawa, K., Omine, M., Hirai, H., Nakauchi, H., Koeffler, P. and Ogawa, S Nature 460 904-909 2009
  •  FRS2beta docking/scaffolding adaptor protein Iejima, D. and Gotoh, N Current research in cancer, 3 99-107 2009
  •  FRS2alpha is required for the separation, migration, and survival of pharyngeal-endoderm derived organs including thyroid, ultimobranchial body, parathyroid, and thymus. Kameda, Y., Ito, M., Nishimaki, T. and Gotoh, N Dev. Dyn 238 503-513 2009
  •  Molecular mechanisms determining efficacy of EGF receptor-specific tyrosine kinase inhibitors help to identify biomarker candidates Yamauchi, M., and Gotoh, N Biomark. Med 3 139-151 2009
  •  Prominent expression of FRS2beta protein in neural cells and its association with intracellular vesicles Minegishi, Y., Iwanari, H., Mochizuki, Y., Horii, T., Hoshino, T., Kodama, T., Hamakubo, T. and Gotoh, N. FEBS lett 583 807-814 2009
  •  The FRS2 family of docking/scaffold adaptor proteins as therapeutic targets of cancer treatment Sato T. and Gotoh, N Expert Opinion on Therapeutic Targets 13 689-700 2009
  •  Control of stemness by fibroblast growth factor signaling in stem cells and cancer stem cells. Gotoh, N Current Stem Cell Research & Therapy 4 9-15 2009
  •  One-carbon metabolism 35 10 46-51 2017
  •  乳がん幹細胞性を維持するシグナル伝達の解析 富永香菜、後藤典子 48 9 423-426 2017
  •  乳癌の癌幹細胞 富永香菜、後藤典子 Surgery Frontier 22 4 61-67 2015
  •  がん幹細胞研究の歴史および治療への展望 後藤典子、佐谷秀行 33 5 676-677 2015
  •  乳がん幹細胞とニッチの増殖因子シグナル 33 5 712-717 2015
  •  Large miRNA survival analysis reveals a prognostic four-biomarker signature for triple negative breast cancer Andrade F, Nakata A, Gotoh N, Fujita A Genet Mol Biol, in press 2020

Conference Presentations

  • Growth factor signaling regulates cancer stem cells and their niche(conference:The 6th Symposium on Anti-tumor Agents and Individual Therapy)(2019/11/24)
  • One carbon metabolic enzymes play important roles for cancer cells and cancer stem-like cells(conference:3rd World Congress on Cancer)(2019/09/23)
  • Growth factor signaling regulates cancer stem cells and their niche(conference:International Symposium of Advances in Cancer Stem Cell Therapeutics)(2019/08/24)
  • The replicative factor MCM10 maintains patient-derived breast cancer stem-like cells that constitutively experience DNA replicative stress(2019/07/31)
  • Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells(conference:Symposium: The State-of-the-Art 3D Tissue Culture & Organoids)(2019/03/18)

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  • Critical roles of luminal progenitor cells in creating the cytokine-rich precancerous niche for mammary tumorigenesis(conference:International Society for Precision Cancer Medicine, 2019)(2019/03/14)
  • Growth factor and cytokine signaling regulates breast cancer stem-like cells and their niche(conference:第7回Cancer Stem Cell Symposium)(2018/12/14)
  • Analysis of regulatory mechanisms in breast cancer-stem like cells by using spheroid cultures of patient-derived cancer cells and patient-derived xenograft (PDX) models(conference:International Symposium on Tumor Biology in Kanazawa)(2018/11/26)
  • Maintenance of stemness and niche environment of breast cancer cells by FRS2β, a feedback inhibitor for HER2-ERK pathway, during mammary tumorigenesis(conference:The 8th FUSCC-CRIKU Joint Symposium on Tumor Biolog)(2018/09/04)
  • Semaphorin signaling via MICAL3 induces symmetric cell division of breast cancer stem-like cells(conference:The 1st Meeting of International Society of Precision Cancer Medicine (ISPCM))(2017/03/16)
  • Growth factor signaling controls breast cancer stem-like cells and their niche(conference:The Korean Sciety for Biochemistry and Molecular Biology (KSBMB) International Conference 2017)(2017/05)
  • Semaphorin signal via MICAL3 induces symmetrical cell division of cancer stem-like cells(conference:2017 AACR Annual Meeting, Symposium “Tumor Stem Cell Biology”)(2017/04)
  • Growth factor signaling controls breast cancer stem-like cells(2017/03)
  • Cancer stem-like cells derived from breast cancer or lung cancer(2017/01)
  • Growth factor signaling in cancer stem-like cells and their niche(conference:The 47th International Symposium of the Princess Takamatsu Cancer Research Fund:Current Status and Perspective of Cancer Stem Cell Research)(2016/11/10)
  • Oncogenic fusion gene CD74-NRG1 confers cancer stem cell-like properties in lung cancer through a IGF2 autocrine/paracrine circuit(conference:The international academic seminar of tumor basis and clinical translational medicine in Jinan university)(2016/10/12)
  • A serine-glycine metabolic enzyme MTHFD2 is a novel molecular target for overcoming resistance in lung cancer(conference:6th FUSCC-CRIKU Joint Symposium on Tumor Biology)(2016/09)
  • Dependence on the mitochondrial MTHFD2-mediated purine synthetic pathway in lung cancer(2016/12/02)
  • A serine-glycine metabolic enzyme MTHFD2 is a novel molecular target for overcoming resistance in lung cancer(2016/10/06)
  • Novel therapeutic strategies to eradicate tumors by targeting cancer stem-like cells(2016/07/29)
  • Stem cells, progenitor cells and cancer stem cells in breast tissues(2016/04/22)
  • CD74-NRG1, an oncogenic fusion gene product, leads to insulin-like growth factor 2 autocrine/paracrine circuit and confers cancer stem cell properties(conference:The 20th Korea-Japan Cancer Research Workshop)(2015/11/30)
  • Molecular targets in the signaling and metabolism in cancer stem cells and their niche(2015/12/01)
  • Molecular targets in the signaling and metabolism in cancer stem cells and their niche(2015/10/09)
  • MICAL3 regulates stemness of human breast cancer(2015/07/16)
  • Maintenance of stemness of breast cancer stem-like cells by FRS2beta, a feedback inhibitor for HER, during mammary tumorigenesis(conference:2015 SNUCRI Cancer Symposium)(2015/04/03)
  • Novel molecular targets for breast and lung cancer stem cells(2015/02/06)

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

Classes (Bachelors)

Classes (Graduate Schools)

○Cancer molecular pathology 1(2017)
○Molecular Pathology(2017)
○Molecular Pathology(2017)
○Cancer molecular pathology 1(2017)
○Cancer molecular pathology 1(2017)
○Molecular Medical Oncology(2017)
○Biology of Cancer 1A(2017)
○Biology of Cancer 1B(2017)
○Molecular and Cellular Pathology(2017)
○Cancer molecular pathology 1(2017)
○Molecular Oncology(2017)
○Biology of Cancer 1A(2016)
○Cancer molecular pathology 1(2016)
○Molecular Oncology(2016)
○Molecular Medical Oncology(2016)
○Molecular Pathology(2016)
○Molecular and Cellular Pathology(2016)
○Molecular Pathology(2016)
○Biology of Cancer 1B(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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