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Researcher Information

last modified：2024/12/21

Associate Professor　KAKIKAWA Makiko

Mail

Faculty, Affiliation

Faculty of Biological Science and Technology,Institute of Science and Engineering

College and School Educational Field

Division of Electrical Engineering and Computer Science, Graduate School of Natural Science and Technology
Division of Electrical Engineering and Computer Science, Graduate School of Natural Science and Technology
Course in Bioengineering, School of Biological Science and Technology, College of Science and Engineering

Laboratory

　TEL:076-264-6601　FAX:076-234-4946

Academic Background

Career

Postdoctoral fellow, Japan Society for the Promotion of Science

Year & Month of Birth

Academic Society


Award

○Thesis prize of Japan Association of Aerosol Science and Technology(2008/08/21)
○Thesis prize of the magnetics society of Japan(2009/09/13)
○Thesis prize of the magnetics society of Japan(2009/09/13)
○Thesis prize of the magnetics society of Japan(2009/09/13)

Specialities

Applied microbiology、Medical systems、Environmental dynamic analysis

Speciality Keywords

protein conformation

Research Themes

Medical application of magnetic fields

Molecular identification of microorganisms in bioaerosols

Books

Papers

  • 　Effect of terahertz radiation on drug activity in bacterial cells　Kakikawa, M., Matsuzuka, R., Yamaguchi, Y.　 Journal of Electromagnetic Waves and Applications 　2024/07/22
  • 　Bone regeneration–enhancing effects of extremely low-frequency electromag-netic fields: Analysis using fish scales as a bone model　Biomedical Research (Tokyo) 　45　5　187-195　2024/10
  • 　Extremely low-frequency electromagnetic fields facilitate both osteoblast and osteoclast activity through Wnt/β-catenin signaling in the zebrafish scale　Jingjing Kobayashi-Sun,Isao Kobayashi,Makoto Kashima,Jun Hirayama,Makiko Kakikawa,Sotoshi Yamada,Nobuo Suzuki　Frontiers in Cell and Developmental Biology　12　2024/02/07　
  • 　Different effects of magnetic field on drug activity in human uterine sarcoma cell lines MES-SA and MES-SA/Dx5　Shibaki. R, Kakikawa, M.　Electromagnetic biology and medicine　41　3　343-351　2022/07
  • 　Exposure to 60 Hz magnetic field can affect membrane proteins and membrane potential in human cancer cells　Hayashi, S., Kakikawa, M.　Electromagnetic biology and medicine　40　4　459-466　2021/08

show all

  • 　Combined Effect of 60 Hz Magnetic Fields and Anticancer Drugs on Human Hepatoma HepG2 Cells　Kakikawa M, Maeda T, Yamada S.　IEEE Journal of Electromagnetics, RF, and Microwaves in Medicine and Biology　3　1　56-60　2019/03
  • 　Gradual Deformation of the Bacterial Cell Morphology due to the Effect of Non-thermal Atmospheric Pressure Plasma jet-Treated Water (PTW)　Begum A, Chiba R, Ishijima T, Kakikawa M, Taoka A, Pervez M. R, Innomata T, Uesugi Y, and Tanaka Y.　IEEE Transactions on Radiation and Plasma Medical Sciences　2　4　360-368　2018/07
  • 　Concentration and viability of bacteria aerosols associated with weather in Asian continental outflow: Current understanding　Zhang D, Murata K, Hu W, Yuan H, Matsusaki H, Kakikawa M.　Aerosol Science and Engineering　1　66-77　2017/08
  • 　Effect of Extremely Low-Frequency (ELF) magnetic fields on the potency of drugs in bacterial cells　Kakikawa M., Imai, S., Yamada S　IEEE Transactions on Magnetics　50　4　1-4　2014/04
  • 　Cell concentration, viability and culture composition of airborne bacteria during a dust event in Beijing　Yuan H., Zhang D., Shi Y., Li B., Yang J., Yu X.,Chen N., Kakikawa M.　Journal of Environmental Sciences　55　33-40　2017/05
  • 　Genetic and biochemical characterization of glutamyl endopeptidase of Staphylococcus warneri M.　Yokoi K,Kakikawa M,Kimoto H,Watanabe K,Yasukawa H,Yamakawa A,Taketo A,Kodaira KI　GENE　281　1-2　115-22　2001/12
  • 　Molecular Identification of Microorganisms in Bioaerosols　Earozoru Kenkyu　25　1　29-34　2010/03
  • 　Effect of Extremely Low-Frequency (ELF) magnetic fields on anticancer drugs potency　Kakikawa M., Yamada S.　IEEE Transactions on Magnetics　48　2869-2872　2012/11
  • 　Determination of calcium sensing receptor in the scales of goldfish and inductionof its mRNA expression by acceleration loading　Kakikawa M, Yamamoto T, Satoh Y, Kitamura K-I, Sekiguchi T, Chowdhury VS, Funahashi H, Omori K, Endo M, Yano S, Yamada S, Hayakawa K, Chiba A, Srivastav AK, Ijiri K, Hattori1 A, Suzuki N.　Biological Sciences in Space,　26　26-31　2012/12
  • 　Enhanced Potency of Anticancer Drug, Bleomycin by ELF Magnetic Fields　Journal of the Japan Society of Applied Electromagnetics　17　3　477-480　2009/09
  • 　Dustborne microorganisms in the atmosphere over an Asian dust source region, Dunhuang　Air Quality, Atmosphere and Health　2　4　195-202　2008/12
  • 　A Review of Studies of the Biological Effects of Electromagnetic Fields in the Intermediate Frequency Range　IEEJ Trans　2　4　405-412　2007/07
  • 　Phylogenetic analysis of atmospheric halotolerant bacterial communities at high altitude in an Asian dust (KOSA) arrival region, Suzu City 　Maki T,Susuki S, Kobayashi F, Kakikawa M,Tobo Y, Yamada M, Higashi T, Matsuki A, Hasegawa H, Iwasaka Y　Science of the Total Environment　408　20　4556-4562　2010/09
  • 　Influence of ELF Magnetic Fields on Anticancer Drug Cisplatin Potency　Journal of the Japan Society of Applied Electromagnetics　17　3　489-492　2009/09
  • 　High Spatial Resolution Measurement of Low Magnetic Fields by Needle-Type GMR Sensor　Journal of the Magnetics Society of Japan　34　4　529-532　2010
  • 　Measurement of Minute Changes in Magnetic Flux Density by Means of a Novel GMR Needle Probe for Application in Hyperthermia Therapy　Journal of the Magnetics Society of Japan　0　0　2010
  • 　GMR Sensor Application in Detecting and Estimating Magnetic Fluid Weight Density inside Various Size Tumors　Journal of the Magnetics Society of Japan　33　3　175-178　2009/05
  • 　Mixture of Kosa (Asian dust) and bioaerosols detected in the atmosphere over the Kosa particles source regions with balloon-borne measurements: Possibility of long-range transport　Air Quality, Atmosphere and Health　2　1　29-38　2009/03
  • 　Estimation of Density of Low-Concentration Magnetic Fluid by a Needle-Type GMR Sensor for Medical Applications　Journal of the Magnetics Society of Japan　32　3　191-194　2008/05
  • 　Study on Atmospheric Diffusion of Bioaerosols in a KOSA Source Region　Earozoru Kenkyu　22　3　218-227　2007/09
  • 　Detection of Magnetic Fluid Volume Density with a GMR Sensor　Journal of Magnetics Society of Japan　31　2　44-47　2007/03
  • 　Phylogenetic Analysis of Halotolerant Bacterial Species Compositions in an Asian Dust (KOSA) Bioaerosol　Earozoru Kenkyu　25　1　35-42　2010/03
  • 　Direct Samplings, Separated Culture, and Identifications of KOSA Bioaerosols over Noto Peninsula, Suzu City　Earozoru Kenkyu　25　1　23-28　2010/03
  • 　The virion proteins encoded by bacteriophage phi K and its host-range mutant phi KhT: host-range determination and DNA binding properties.　Kodaira K,Oki M,Kakikawa M,Kimoto H,Taketo A　J Biochem　119　6　1062-9　1996
  • 　Effects on the Attraction and Avoidance Behavior of C. elegans by Exposure to ELF Magnetic Fields(Biomagnetic and Medical Application)　Journal of Magnetics Society of Japan　30　3　418-421　2006/05
  • 　Effects on Bacterial Cells of Exposure to Very-Low-Frequency Magnetic Fields(Biomagnetic and Medical Applications)　Journal of Magnetics Society of Japan　29　3　356-359　2005/03
  • 　Action of Cavitation Phenomena Generated by Giant Magnetostrictive Actuator to Inactivation of Phage　Journal of the Magnetics Society of Japan　0　0　2010
  • 　Genome structure of a Lactobacillus plasmid pNMO belonging to the rolling-circle type replocon　Oki M., Kakikawa M., Taketo A., Kodaira K.-I.　J.Gen. Appli. Microbiol.,　42　271-283　1996
  • 　Characterization of the major tail protein gpP encoded by Lactobacillus plantarum phi g1e　Kakikawa M., Yamakawa A., Yokoi K.-J., Nakamura S., Taketo A., Kodaira K.-I.　6　185-191　2002/06
  • 　Characterization of halotolerant and oligotrophic bacterial communities in Asian desert dust (KOSA) bioaerosol accumulated in layers of snow on Mount Tateyama, Central Japan　Maki　T, Aoki K, Kobayashi F, Kakikawa M, Tobo Y, Matsuki A, Hasegawa H, Iwasaka Y　Aerobiologia　27　227-290　2011/12
  • 　Cloning of two members of the calcitonin-family receptors from stingray, Dasyatis akajei: Possible physiological roles of the calcitonin family in osmoregulation　Suzuki N,　Sekiguchi T,　Satake H,　Kato, K,　Nishiyama Y,　Takahashi H,　Danks JA,　Martin TJ,　Hattori A,　Nakano M,　Kakikawa M,　Yamada S,　Ogoshi M,　Hyodo S,　Yamaguchi Y,　Chowdhury VS,　Hayakawa K,　Funahashi H,　Sakamoto T,　Sasayama Y.　GENE　499　326-331　2012/05
  • 　Spectroscopic Susceptibility Measurements of Magnetic Markers by SV-GMR Needle Probe　Journal of the Magnetics Society of Japan　35　2　157-162　2011
  • 　Molecular analysis of the lysis protein Lys encoded by Lactobacillus plantarum phage phig1e.　Kakikawa M,Yokoi KJ,Kimoto H,Nakano M,Kawasaki K,Taketo A,Kodaira K　GENE　299　1-2　227-34　2002/10
  • 　Purification and biochemical properties of an N-hydroxyarylamine O-acetyltransferase from Escherichia coli.　Yamamura E,Sayama M,Kakikawa M,Mori M,Taketo A,Kodaira K　Biochim Biophys Acta　1475　1　10-6　2000/06
  • 　The genetic switch for the regulatory pathway of Lactobacillus plantarum phage (phi)g1e: characterization of the promoter P(L), the repressor gene cpg, and the cpg-encoded protein Cpg in Escherichia coli.　Kakikawa M,Ohkubo S,Syama M,Taketo A,Kodaira KI　GENE　242　1-2　155-66　2000/01
  • 　Cloning and nucleotide sequence of the major capsid proteins of Lactobacillus bacteriophage phi gle　Kakikawa, M., Oki M., Tadokoro H., Nakamura S., Taketo A., Kodaira K.-I.　Gene　175　157-165　1996/10
  • 　Assessment of composition and origin of airborne bacteria in the free troposphere over Japan　ATMOSPHERIC ENVIRONMENT　74　73-82　2013/08
  • 　Mutagenicities of 2,4- and 2,6-dinitrotoluenes and their reduced products in Salmonella typhimurium nitroreductase- and O-acetyltransferase-overproducing Ames test strains　Sayama M., Mori M., Shoji M., Uda S., Kakikawa M., Kondo T., Kodaira K.-I.　Mutation Research　420　27-32　1998/12
  • 　Effects of deifferent temperature treatments on biological ice nuclei in snow samples, Atmospheric Environment　Hara K, Maki T, Kakikawa M, Kobayashi F, Matsuki A　 Atmospheric Environment　140　415-419　2016/09
  • 　Variations of ice nuclei concentration induced by rain and snowfall within a local forested site in Japan　Hara K, Maki T, Kobayashi F, Kakikawa M, Wada M, Matsuki A　Atmospheric Environment　127　1-5　2016/02
  • 　Atmospheric bioaerosols originating from Adélie penguins (Pygoscelis adeliae): ecological observations of airborne bacteria at Hukuro Cove, Langhovde, Antarctica　Kobayashi F, Maki T, Kakikawa M, Noda T, Mitamura H, Takahashi A, Imura S, Iwasaka Y　Polar Science　10　71-78　2016/03
  • 　Vertical distribution of airborne bacterial communities in an Asian dust downwind area, Noto Peninsula, 　Maki T., Hara K., Kobayashi F., Kurosaki Y., Kakikawa M., Matsuki A., Chen B., Shi G., Hasegawa H., Iwasaka Y.　Atmospheric Environment　119　282-293　2015/08
  • 　Bioprocess of Kosa bioaerosols: effect of 1 ultraviolet radiation on airborne bacteria within Kosa (Asian dust)　Kobayashi F, Maki T, Kakikawa M, Yamada M, Puspitasari F, Iwasaka Y　Journal of Bioscience and Bioengineering　199　570-579　2015/02
  • 　Mutagenic and physiological effects on the bacterial cell by exposure to magnetic fields　Kakikawa M, Hosono R, Hashimoto S, Iwahara M, Yamada S,　J. Jpn. Soc. Appl. Electromagn. Mechan,　15　199-202　2005/08
  • 　Novel GMR Sensor for Estimation of Magnetic Nanoparticles inside Minute Cavities　Journal of the Japan Society of Applied Electromagnetics　17　3　457-460　2009/09
  • 　Purification and DNA-binding properties of the cro-type regulatory repressor protein cng encoded by the Lactobacillus plantarum phage phi g1e.　Kakikawa M,Ohkubo S,Sakate T,Sayama M,Taketo A,Kodaira K　GENE　249　1-2　161-9　2000/05
  • 　Purification and DNA-binding properties of the integrase protein Int encoded by Lactobacillus plantarum phage.　Yasukawa H,Kakikawa M,Masamune Y,Taketo A,Kodaira KI　GENE　204　1-2　219-25　1997/12
  • 　Application of Giant Magnetostrictive Actuator in the Generation of Radicals　Journal of the Japan Society of Applied Electromagnetics　17　0　S145-S148　2009/09
  • 　Genome structure of the Lactobacillus temperate phage phi g1e: the whole genome sequence and the putative promoter/repressor system　Kodaira K.-I., Oki M., Kakikawa M., Watanabe N., Hirakawa M., Yamada K., Taketo A.　Gene　187　45-53　1997/03
  • 　Monitoring minute changes of magnetic Markers' susceptibility by SV-GMR needle-type probe　Haraszczuk, R., Yamada, S., Kakikawa, M., Ueno, T.　IEEE TRANSACTIONS ON MAGNETICS　47　2584-2587　2011/10
  • 　Functional and structural features of the holin HOL protein of the Lactobacillus plantarum phage phi gle: analysis in Escherichia coli system.　Oki M,Kakikawa M,Nakamura S,Yamamura ET,Watanabe K,Sasamoto M,Taketo A,Kodaira K　GENE　197　1-2　137-45　1997/09
  • 　Promoter/repressor system of Lactobacillus plantarum phage og1e: characterization of the promoters pR49-pR-pL and overproduction of the cro-like protein cng in Escherichia coli.　Kakikawa M,Watanabe N,Funawatashi T,Oki M,Yasukawa H,Taketo A,Kodaira KI　GENE　215　2　371-9　1998/07
  • 　Cloning, sequence analysis, and expression of the genes encoding lytic functions of Bacteriophage phi g1e　Oki M., Kakikawa M., Yamada K., Taketo A., Kodaira K.-I.　Gene　176　215-223　1996/10
  • 　Characterization of the genes encoding integrative and excisive functions of Lactobacillus phage phi g1e: cloning, sequence analysis, and expression in Escherichia coli　Kakikawa M., Oki M., Watanabe N., Yasukawa H., Masamune Y., Taketo A., Kodaira K.-I.　Gene　185　119-125　1997/01

Conference Presentations

Others

  • 　Biological Effect of magnetic fields　84　 456　2006/11

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「薬物取込タンパク質への磁場影響メカニズムの解明」(2022-2024)　
○「抗がん剤作用への磁場影響メカニズムの解明」(2019-2021)　
○「超磁歪アクチュエータによるパルスパワー生成と殺菌・ウイルス失活作用の研究」(2010-2011)　
○「交流磁場併用による抗がん剤薬理作用増強効果を利用した新規化学療法の開発」(2016-2018)　
○「砂漠上空での砂塵とバイオエアロゾルの混合状態に関する野外研究：気球による直接採集」(2008-2010)　
○「マイクロ駆動機構を持つ針状磁気抵抗効果プローブによる低侵襲・非破壊計測の開発 」(2010-2012)　
○「磁場と抗がん剤の併用療法に関する基礎的研究」(2006-2007)　
○「自由大気圏を長距離移動するバイオエアロゾルが遺伝子の水平伝播に及ぼす影響」(2012-2014)　
○「交流磁場を用いた抗がん剤の標的治療技術の開発」(2012-2014)　
○「交流磁場によるがん標的化学療法の開発」(2015-2017)　
○「乳酸菌の分子育種:遺伝子導入並びに発現系の構築 」(1999-2001)　
○「交流磁場と抗がん剤の併用治療法の開発」(2010-2011)　

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Introduction to Information Technology(2017)
○Student-Initiated Project(2017)
○Design of Biological Information System(2017)
○Introduction to Information Technology(2016)
○Design of Biological Information System(2016)
○Student-Initiated Project(2016)

Classes (Graduate Schools)

○Foundation of Genome informatics A(2017)
○Foundation of Genome informatics A(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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