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Researcher Information

last modified:2017/05/23

Assistant Professor Sekiguchi Toshio

Mail Laboratory Website

Faculty, Affiliation

Institute of Nature and Environmental Technology Noto Marine Laboratory, Institute of Nature and Environmental Technology

College and School Educational Field

Division of Natural Sciences, Graduate School of Natural Science and Technology

Laboratory

Noto Marine Laboratory Institute of Nature and Environmental Technology TEL:0768-74-1151 FAX:0768-74-1644

Academic Background

【Academic background(Bachelor's Degree)】
Saitama University 199803
【Degree】
Ph.D.

Career

Year & Month of Birth

1974/01

Academic Society



Award

Specialities

Speciality Keywords

Research Themes

Books

Papers

  •  Calcitonin-typical suppression of osteoclastic activity by amphioxus calcitonin superfamily peptides and insights into the evolutionary conservation and diversity of their structures. Sekiguchi, T., Shiraishi, A., Satake, H., Kuwasako, K., Takahashi, H., Sato, M., Urata, M., Wada, S., Endo, M., Ikari, T., Hattori, A., Srivastav, A.K., Suzuki, N. Gen. Comp. Endocrinol. in press in press in press 2017/01
  •  Effects of low-intensity pulsed ultrasound on osteoclasts: analysis with goldfish scales as a model of bone. Hanmoto, T., Tabuchi, Y., Ikegame, M., Kondo, T., Kitamura, K., Endo, M., Kobayashi, I., Mishima, H., Sekiguchi, T., Urata, M., Seki A., Yano, S., Hattori, A., Suzuki, N. Biomed. Res. in press in press in press 2017
  •  Identification and molecular characterization of the stanniocalcin family gene from the inshore hagfish, Eptatretus burgeri. Sekiguchi, T., Kuraku, S., Tatsumi, K., Shimasaki, Y., Oshima, Y., Suzuki, N. J. Fac. Agr., Kyushu Univ. 62 1 93-98 2017/02
  •  Pollution of radiocesium and radiosilver in wharf roach (Ligia sp.) by the Fukushima Dai-ichi Nuclear Power Plant accident. Qiu, X., Undap, S.L., Honda, M., Sekiguchi, T., Suzuki, N., Shimasaki, Y., Ando, H., Sato-Okoshi, W., Wada, T., Sunobe, T., Takeda, S., Munehara, H., Yokoyama H., Momoshima, N., Oshima, Y. J. Radioanal Nucl Chem. 311 1 121-126 2017/01
  •  Sodium fluoride induces hypercalcemia resulting from the upregulation of both osteoblastic and osteoclastic activities in goldfish, Carassius auratus. Sato, M., Hanmoto, T., Yachiguchi, K., Tabuchi, Y., Kondo, T., Endo, M., Kitani, Y., Sekiguchi, T., Urata, M., Hai, T.N., Srivastav, A.K., Mishima, H., Hattori, A., Suzuki, N. Comp. Biochem. Physiol. Part C. 189 54-60 2016/11

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  •  Seawater polluted with highly concentrated polycyclic aromatic hydrocarbons suppresses osteoblastic activity in the scales of goldfish, Carassius auratus. Suzuki, N., Sato, M., Nassar, F. H., Abdel-gawad, F. Kh., Bassem, S.M., Yachiguchi, K., Tabuchi, Y., Endo, M., Sekiguchi, T., Urata, M., Hattori, A., Mishima, H., Shimasaki, Y., Oshima, Y., Hong, C.-S., Makino, F., Tang, N., Toriba, A., Hayakawa, K. Zool. Sci. 33 4 407-413 2016/08
  •  Low-intensity pulsed ultrasound induces apoptosis in osteoclasts: Fish scales are a suitable model for analysis of bone metabolism by ultrasound. Suzuki, N., Hanmoto, T., Yano, S., Furusawa, Y., Ikegame, M., Tabuchi, Y., Kondo, T., Kitamura, K., Endo, M., Yamamoto, T., Sekiguchi, T., Urata, M., Mikuni-Takagaki, Y., Hattori, A. Comp. Biochem. Physiol. Part A. 195 26-31 2016/05
  •  Inhibitory effects of two G protein-coupled receptor kinases on the cell surface expression and signaling of the human adrenomedullin receptor. Kuwasako, K., Sekiguchi, T., Nagata, S., Jiang, D., Hayashi, H., Murakami, M., Hattori, Y., Kitamura, K. and Kato, J. Biochem. Biophys. Res. Commun. 470 4 894-899 2016/02
  •  Evidence for conservation of the calcitonin superfamily and activity-regulating mechanisms in the basal chordate Branchiostoma floridae: insight into the molecular and functional evolution in chordates. Sekiguchi, T., Kuwasako, K., Ogasawara, M., Takahashi, H., Matsubara, S., Osugi, T., Muramatsu, I., Sasayama, Y., Suzuki, N., and Satake, H. J. Biol. Chem. 291 5 2345-2356 2016/01
  •  Novel tryptophan derivatives as potentially effective therapeutic drugs to treat bone diseases.  Suzuki, N., Somei, M., Seki, A., Sekiguchi, T., Tabuchi, Y., Mishima, H., Kase, Y., Kaminishi, A., Yachiguchi, K., Kitamura, K., Oshima, Y., Hayakawa, K., Yano, S. and Hattori, A. Am. J. Life Sci. 3 31-38 2015/05
  •  Monohydroxylated polycyclic aromatic hydrocarbons influence spicule formation in the early development of sea urchins (Hemicentrotus pulcherrimus). Suzuki, N., Ogiso, S., Yachiguchi, K., Kawabe, K., Makino, F., Toriba, A., Kiyomoto, M., Sekiguchi, T., Tabuchi, Y., Kondo, T., Kitamura, K., Hong, C.-S., Srivastav, A.K., Oshima, Y., Hattori, A., Hayakawa, K. Comp. Biochem. Physiol. Part C 171 55-60 2015/05
  •  Polychlorinated biphenyl (118) activates osteoclasts and induces bone resorption in goldfish. Yachiguchi, K., Matsumoto, N., Haga, Y., Suzuki, M., Matsumura, C., Tsurukawa, M., Okuno, T., Nakano, T., Kawabe, K., Kitamura, K., Toriba, A., Hayakawa, K., Chowdhury, V.S., Endo, M., Chiba, A., Sekiguchi, T., Nakano, M., Tabuchi, Y., Kondo, T., Wada, S., Mishima, H., Hattori, A. and Suzuki, N. Env. Sci. Poll. Res. 21 6365–6372 2014/05
  •  Effect of inorganic mercury and methylmercury on osteoclasts and osteoblasts in the scales of the marine teleost as a model system of bone. Yachiguchi, K., Sekiguchi, T., Nakano, M., Hattori, A., Yamamoto, M., Kitamura, K., Maeda, M., Tabuchi, Y., Kondo, T., Kamauchi, H., Nakabayashi, H., Srivastav, A.K., Hayakawa, K., Sakamoto, T. and Suzuki, N Zool. Sci. 31 5 330-337 2014/05
  •  Increased prostaglandin E2 has a positive correlation with plasma calcium during goldfish reproduction. Suzuki, N., Maruyama, Y., Nakano, M., Hattori, A., Honda, M., Shimazaki, Y., Sekiguchi, T., Mishima, H., Wada, S., Srivastav, A.K., Hayakawa, K. and Oshima, Y. J. Fac. Agr., Kyushu Univ. 59 97-101 2014
  •  Accumulation of organotins in wharf roach (Ligia exotica Roux) and its ability to serve as a biomonitoring species for coastal pollution. Undap, SL., Matsunaga, S., Honda, M., Sekiguchi, T., Suzuki, N., Khalil, F., Qiu, X., Shimasaki, Y., Ando, H., Sato-Okoshi, W., Sunobe, T., Takeda, S., Munehara, H., Oshima, Y. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 96 1 75-79 2013/10
  •  Static and dynamic hypergravity responses of osteoblasts and osteoclasts in medaka scales. Yano, S., Kitamura, K., Satoh, Y., Nakano, M., Hattori, A., Sekiguchi, T., Ikegame, M., Nakashima, H., Omori, K., Hayakawa, K., Chiba, A., Sasayama, Y., Ejiri, S., Mikuni-Takagaki, Y., Mishima, H., Funahashi, H., Sakamoto, T., Suzuki, N ZOOLOGICAL SCIENCE 30 3 217-223 2013/03
  •  Determination of calcium sensing receptor in the scales of goldfish and induction of its mRNA expression by acceleration loading. 29. Kakikawa, M., Yamamoto, T., Chowdhury, V.S., Satoh, Y., Kitamura, K., Sekiguchi, T., Funahashi, H., Omori, K., Endo, M., Yano, S., Yamada, S., Hayakawa, K., Chiba, A., Srivastav, A.K., Ijiri, K., Hattori, A., Suzuki, N. BIOLOGICAL SCIENCE IN SPACE 26 26-31 2012/12
  •  Insight into molecular and functional diversity of tachykinins and their receptors.  Satake, H., Aoyama, M., Sekiguchi, T., Kawada, T PROTEIN AND PEPTIDE LETTERS 20 6 615-627 2012/06
  •  Cloning of two members of the calcitonin-family receptors from stingray, Dasyatis akajei: Possible physiological roles of the calcitonin family in osmoregulation. Suzuki, N., Sekiguchi, T., Satake, H., Kato, K., Nishiyama, Y., Takahashi, H., Danks, J.A., Martin, J., Hattori, A., Nakano, M., Kakikawa, M., Yamada, S., Ogoshi, M., Hyodo, S., Yamaguchi, Y., Chowdhury, V.S., Hayakawa, K., Funahashi, H., Sakamoto, T., Sasayama, Y. GENE 499 2 326-331 2012/05
  •  Molecular and functional characterization of cionin receptors in the ascidian, Ciona intestinalis: the evolutionary origin of the vertebrate cholecystokinin/gastrin family. Sekiguchi, T., Ogasawara, M., Satake, H. JOURNAL OF ENDOCRINOLOGY 213 1 99-106 2012/04
  •  Toll-like receptors of deuterostome invertebrates. Satake, H., Sekiguchi, T. FRONTIERS IN IMMUNOLOGY 29 3 34 2012/02
  •  Peptidomic analysis of the central nervous system of the protochordate, Ciona intestinalis: homologs and prototypes of vertebrate peptides and novel peptides. Kawada, T., Ogasawara, M., Sekiguchi, T., Aoyama, M., Hotta, K., Oka, K., Satake, H. ENDOCRINOLOGY 156 6 2416-2427 2011/06
  •  Neuropeptides, Hormone Peptides, and Their Receptors in Ciona instinalis: an update. Kawada, T., Sekiguchi, T., Sakai, T., Aoyama, M., Satake, H.  ZOOLOGICAL SCIENCE 27 134-153 2010/02
  •  A novel inhibitory gonadotropin-releasing hormone-related neuropeptide in the ascidian, Ciona intestinalis. 23. Kawada, T., Aoyama, M., Okada, I., Sakai, T., Sekiguchi, T., Ogasawara, M., Satake, H. PEPTIDES 30 12 2200-2205 2009/12
  •  Calcitonin in a protochordate, Ciona intestinalis-the prototype of the vertebrate calcitonin/calcitonin gene-related peptide superfamily. Sekiguchi, T., Suzuki, N., Fujiwara, N., Aoyama, M., Kawada, T., Sugase, K., Murata, Y., Sasayama, Y., Ogasawara, M., Satake, H. FEBS JOURNAL 276 16 4437-4447 2009/10
  •  Toll-like receptors of the ascidian, Ciona intestinalis: prototypes with hybrid functionalities of vertebrate Toll-like receptors. 22. Sasaki, N., Ogasawara, M., Sekiguchi, T., Kusumoto, S., Satake, H. JOURNAL OF BIOLOGICAL CHEMISTRY 284 40 27336-27343 2009/10
  •  Characterization of a novel vasopressin/oxytocin superfamily peptide and its receptor from an ascidian, Ciona intestinalis. Kawada, T., Sekiguchi, T., Itoh, Y., Ogasawara, M., Satake, H. PEPTIDES 29 1672-1678 2008/10
  •  A novel biological role of tachykinins as an up-regulator of oocyte growth: identification of an evolutionary origin of tachykininergic functions in the ovary of the ascidian, Ciona intestinalis. Aoyama, M., Kawada, T., Fujie, M., Hotta, K., Sakai, T., Sekiguchi T., Oka, K., Satoh, N., Satake, H. ENDOCRINOLOGY 149 9 4346-4356 2008/09
  •  Neuropeptides and their receptors of the protochordate, Ciona intestinalis: the evolutionary origin of vertebrate neuropeptides. Satake, H., Aoyama, M., Kawada, T., Sekiguchi, T., Sakai, T., Fujie, M., Satoh, N. ACTA BIOLOGICA HUNGARICA 59  237-239 2008/06
  •   Differentiation of adult stem cells derived from bone marrow stroma into Leydig or adrenocortical cells. Yazawa, T., Mizutani, T., Yamada, K., Kawata, H., Sekiguchi, T., Kajitani, T., Shou, Z., Umezawa, A., Miyamoto, K. ENDOCRINOLOGY 149 4 4104-4111 2008/04
  •  Further EST analysis of endocrine genes that are preferentially expressed in the neural complex of Ciona intestinalis: Receptor and enzyme genes associated with endocrine system in the neural complex. Sekiguchi, T., Kawashima, T., Satou, Y., Satoh, N. GENERAL AND COMPARATIVE ENDOCRINOLOGY 150 2 233-245 2007/01
  •  Co-activator p120 is increased by gonadotropins in the rat ovary and enhances progesterone receptor activity. Yoshino, M., Mizutani, T., Yamada, K., Yazawa, T., Ogata, K.H., Sekiguchi, T., Kajitani, T., Miyamoto, K. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 4 50 2006/10
  •  Transcriptional regulation of the Epiregulin gene in the rat ovary. Sekiguchi, T., Mizutani, T., Yamada, K., Yazawa, T., Kawata, H., Yoshino, M., Kajitani, T., Kameda, T., Minegishi, T., Miyamoto, K. ENDOCRINOLOGY 143 12 4718-4729 2002/12
  •  Expression of epiregulin and amphiregulin in the rat ovary. Sekiguchi, T., Mizutani, T., Yamada, K., Kajitani, T., Yazawa, T., Yoshino, M., Miyamoto, K. JOURNAL OF MOLECULAR ENDOCRINOLOGY 33 1 281-291 2004/10
  •  Cloning and characterization of GCX-1, a novel HMG-box transcriptional regulator strongly expressed in rat ovarian granulosa cells. Kajitani, T., Mizutani, T., Yamada, K., Yazawa, T., Sekiguchi, T., Yoshino, M., Kawata, H., Miyamoto, K. ENDOCRINOLOGY 145 5 2307-2318 2004/05
  •  Gene expression of basic helix-loop-helix transcription factor, SHARP-2, is regulated by gonadotropins in the rat ovary and MA-10 cells. Yamada, K., Kawata, H., Mizutani, T., Arima, T., Yazawa, T., Matsuura, K., Shou, Z., Sekiguchi, T., Yoshino, M., Kajitani, T., Miyamoto, K. BIOLOGY OF REPRODUCTION 70 1 76-82 2004/01
  •  Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. Kawata, H., Yamada, K., Shou, Z., Mizutani, T., Yazawa, T., Yoshino, M., Sekiguchi, T., Kajitani, T., Miyamoto, K. BIOCHEMICAL JOURNAL 737 Pt3 747-757 2003/08
  •  Genomic structure and analysis of transcriptional regulation of the mouse zinc-fingers and homeoboxes 1 (ZHX1) gene. Shou, Z., Yamada, K., Inazu, T., Kawata, H., Hirano, S., Mizutani, T., Yazawa, T., Sekiguchi, T., Yoshino, M., Kajitani, T., Okada, K.-I., Miyamoto, K. GENE 302 1-2 83-94 2003/01
  •  Analysis of zinc-fingers and homeoboxes (ZHX) 1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3. Yamada, K., Kawata, H., Shou, Z., Hirano, S., Mizutani, T., Yazawa, T., Sekiguchi, T., Yoshino, M., Kajitani, T., Miyamoto, K. BIOCHEMICAL JOURNAL 373 Pt1 167-178 2003/07
  •  Involvement of cyclic adenosine 5'-monophosphate response element-binding protein, steroidogenic factor 1, and dax-1 in the regulation of gonadotropin-inducible ovarian transcription factor 1 gene expression by follicle-stimulating hormone in ovarian granulosa cells. Yazawa, T., Mizutani, T., Yamada, K., Kawata, H., Sekiguchi, T., Yoshino, M., Kajitani, T., Shou, Z., Miyamoto, K. ENDOCRINOLOGY 144 5 1920-1930  2003/05
  •  Functional analysis and the molecular dissection of zinc-fingers and homeoboxes 1 (ZHX1).  Yamada, K., Kawata, H., Matsuura, K., Shou, Z., Hirano, S., Mizutani, T., Yazawa, T., Yoshino, M., Sekiguchi, T., Kajitani, T., Miyamoto, K. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 297 2 368-374 2002/09
  •  Adrenocorticotropin-like immunoreactivity in the granules of neural complex cells of the Ascidian Halocynthia roretzi.  Kawahara, G., Terakado, K., Sekiguchi, T., Inoue, K., Kikuyama, S. ZOOLOGICAL SCIENCE 19 9 1061-1065 2002/09
  •  Rat zinc-fingers and homeoboxes 1 (ZHX1), a nuclear factor-YA-interacting nuclear protein, forms a homodimer. Hirano, S., Yamada, K., Kawata, H., Shou, Z., Mizutani, T., Yazawa, T., Kajitani, T., Sekiguchi, T., Yoshino, M., Shigematsu, Y., Mayumi, M., Miyamoto, K. GENE 290 1-2 107-114 2002/05
  •  Molecular cloning of natriuretic-peptide receptor A from bullfrog (Rana catesbeiana) brain and its functional expression. Sekiguchi, T., Miyamoto, K., Mizutani, T., Yamada, K., Yazawa, T., Yoshino, M., Minegishi, T., Takei, Y., Kangawa, K., Minamino, N., Saito, Y., Kojima, M. GENE 273 2 251-257 2001/08
  •  Cloning and functional expression of an E box-binding protein from rat granulosa cells. Yamada, K., Mizutani, T., Shou, Z., Yazawa, T., Sekiguchi, T., Yoshino, M., Inazu, T., Miyamoto, K. BIOLOGY OF REPRODUCTION 64 5 1315-1319 2001/05

Conference Presentations

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「硬骨を持たない原始的脊椎動物ヤツメウナギにおける新規カルシウム代謝機構 の解明」(2015-2017) 
○「消化管ペプチドの機能進化の研究:ホヤの受容体トランスジェニック個体を用いた解析」(2013-2014) 
○「ペプチド-受容体―受容体修飾蛋白の共進化機構解明:ナメクジウオカルシトニンの研究」(2011-2012)

Classes (Bachelors)

○Research Seminar in Biology (1)(2017)
○Research Work in Biology(2)(2017)
○Field Work in Biology 4(2017)
○Research Work in Biology(1)(2017)
○Research Seminar in Biology (2)(2017)
○Marine Biochemistry(2017)
○Marine Biochemistry(2017)
○Research Work in Biology(1)(2016)
○Research Seminar in Biology (2)(2016)
○Research Seminar in Biology (1)(2016)
○A Marine Exercise in Noto Peninsula(2016)
○Marine Biochemistry(2016)
○Marine Biochemistry(2016)
○A Marine Exercise in Noto Peninsula(2016)
○Research Work in Biology(2)(2016)
○Field Work in Biology 4(2016)

Classes (Graduate Schools)

○Integrated Systems Biology B(2017)
○Integrated Systems Biology A(2017)

International Project

International Students

Lecture themes

Others (Social Activities)

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