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Researcher Information

last modified:2017/06/29

Professor MASUDA Kazumi

Mail Laboratory Website

Faculty, Affiliation

Faculty of Human Sciences, Institute of Human and Social Sciences Faculty of Human Sciences

College and School Educational Field

Division of Humanities,Graduate School of Human and Socio-Environment Studies
Division of Life Sciences, Graduate School of Natural Science and Technology
Graduate School of Natural Science and Technology
Health and Sport Science Course, School of Regional Development Studies, College of Human and Social Sciences

Laboratory

Exercise Physiology and Biochemistry Laboratory TEL:076-264-5568 FAX:076-234-4100

Academic Background

【Academic background(Doctoral/Master's Degree)】
University of Tsukuba Doctor Sport Sciences 199903 Completed
【Academic background(Bachelor's Degree)】
University of Tsukuba School of Health and Physical Education 199403
Liverpool Polytechnic Diploma in Science and Football Course 199207
【Degree】
Ph.D. of Sport Sciences

Career

University of Tsukuba Center for Tsukuba Advanced Research All(1999/04/01-2000/03/31)
University of Tsukuba Center for Tsukuba Advanced Research All(2000/04/01-2001/12/31)
Kanazawa University Faculty of Education(2002/01/01-2009/03/31)
University of California Davis University of California Davis Visiting Scholar(2005/08/29-2006/08/15)

Year & Month of Birth

Academic Society



Japanese Society of Physicl Fitness and Sports Medicine, Hokuriku Area
Sports Coaching Society
Hokuriku Society of Physical Education

The European College of Sport Sciences
The American Physiological Society
Oxygen Dynamics Society
American College of Sports Medicine
Japanese Society of Science and Football
Japan Society of Exercise and Spotrs Physiology
Japanese Society of Physicl Fitness and Sports Medicine

Award

Japanese Society of Physicl Fitness and Sports Medicine
Japanese Society of Physicl Fitness and Sports Medicine
○The 3rd Place in The Best Poster Presenter(2016/10/04)
○Meiji Life Foundation of Health and Welfare 2001(2002/03/12)
○The Uehara Memorial Foundation 2002(2003/03/11)
○The Mikiya Science and Technology Foundation 2002(2003/03/03)
○2005 The Descente and Ishimoto Memorial Foundation for Promotion of Sports Science(2005/04/01)
○Yamaha Motor Foundation for Sports 2007(2007/04/01)
○The Best Young Investigator Award(2008/08/03)
○Shibuya Science and Sports Culture Foundation(2008/11/21)
○Nakatomi Foundation(2009/02/02)
○Yamaha Motor Foundation for Sports 2009(2009/03/27)
○Meiji-Yasuda Foundation(2009/02/20)
○Meiji-Yasuda Foundation(2009/02/20)
○Meiji-Yasuda Foundation(2009/02/20)
○Meiji-Yasuda Foundation(2009/02/20)
○Meiji-Yasuda Foundation(2009/02/20)
○Meiji-Yasuda Foundation(2009/02/20)
○Meiji-Yasuda Foundation(2009/02/20)
○Meiji-Yasuda Foundation(2009/02/20)
○Meiji-Yasuda Foundation(2009/02/20)
○Meiji-Yasuda Foundation(2009/02/20)
○Meiji-Yasuda Foundation(2009/02/20)
○Meiji-Yasuda Foundation(2009/02/20)
○ACSM Noninvasive Investigations of the Neuromuscular System Interest Group Award(2009/05/27)
○ACSM Noninvasive Investigations of the Neuromuscular System Interest Group Award(2009/05/27)
○ACSM Noninvasive Investigations of the Neuromuscular System Interest Group Award(2009/05/27)
○ACSM Noninvasive Investigations of the Neuromuscular System Interest Group Award(2009/05/27)
○ACSM Noninvasive Investigations of the Neuromuscular System Interest Group Award(2009/05/27)
○ACSM Noninvasive Investigations of the Neuromuscular System Interest Group Award(2009/05/27)

Specialities

Sports science、Environmental physiology (including physical medicine and nutritional physiology)、Biomedical engineering/Biomaterial science and engineering

Speciality Keywords

mitochondoria, free radical, oxidative stress, redox, skeletal muscle physilogy, oxidative metabolism, exercise and sport physilogy

Research Themes

Molecular regulation of oxygen transport to muscle tissue and mitochondria bioenergetics during exercise

Molecular regulation of oxygen transport to muscle tissue and mitochondria bioenergetics during exercise Mitochondria function is essential key role on metabolic properties in myocytes. We need to understand the functional interactions of proteins and molecules surrounding mitochondria. Our current research focuses on function of hemeprotein family, especially myoglobin within the cells, including an interaction of myoglobin with mitochondria bioenergetics.

Molecular determinants for selectivity of substrates in skeletal muscle during exercise

Molecular determinants for selectivity of substrates in skeletal muscle during exercise Skeletal muscle consisted of several types of muscle fibers, which contractile and metabolic properties differ. These differences result on usage of substrates for energy production. Our current research focuses on fat metabolism, especially on substrate transport across the plasma membrane, its delivery pathway into mitochondria and molecular interactions in order to understand substrate selectivity in muscles.

Exercise induced free radical, oxidative stress and regeneration of myocytes

Exercise induced free radical, oxidative stress and regeneration of myocytes Since reactive oxygen species (ROS) has much higher reaction than stable oxygen, it causes oxidative damage to tissues if it excesses in vivo. Exercise where tissue oxygen consumption increase, turns out to increase in chance of oxidative damage in vivo. However, ROS affects gene transcription, cell growth and proliferation, and also is intracellular signal per se on the molecular basis. Our current research focuses on role of ROS and effect of antioxidants on muscle regeneration from damage to optimize the exercise prescription and nutrients aid.

Books

  •  Thomas Jue, Kazumi Masuda Inracellular oxygen dynamics observed by NIRS during skeletal muscle contraction. In Application of Near Infrared Spectroscopy in Biomedicine, (Series: Handbook of Modern Biophysics, Vol. 4, Jue T & Masuda K Eds) Springer 2013/04

Papers

  •  Fermented grain beverage supplementation following exercise promotes glycogen supercompensation in rodent skeletal muscle and liver Shibaguchi T, Ishizawa R, Tsuji A, Yamazaki Y, Matsui K, Masuda K Indonesian J Sci Tech 2017
  •  Effect of exercise-mimic stimulation on mitochondrial biogenesis in rat myocytes Machino A, Ishizawa R, Shibaguchi T, Masuda K 北陸体育学会紀要 2017/03
  •  Intracellular oxygen tension limits muscle contraction-induced change in muscle oxygen consumption under hypoxic conditions during Hb-free perfusion Takakura H, Ojino M, Jue T, Yamada T, Furuichi Y, Hashimoto T, Iwase S, Masuda K Physiological Reports 5 e13112 2017/01
  •  Mitochondrial biogenesis induced by exercise and nutrients: implication for performance and health benefits Masuda K, Jue T, Hamidie DRR Indonesian J Sci Tech 2017
  •  Effects of different fatty acid chain lengths on fatty acid oxidation-related proteins in skeletal muscles Ishizawa R et al.  J Oleo Sci 64 415-421 2015/03

show all

  •  Curcumin treatment enhances the effect of exercise on mitochondrial biogenesis in skeletal muscle by increasing cAMP levels Hamidie DRR et al. Metabolism 64 1334-1347 2015/07
  •  Myoglobin and the regulation of mitochondrial respiratory chain complex IV Yamada T et al. Journal of Physiology 594 483-495 2016/01
  •  Endurance training facilitates myoglobin desaturation during muscle contraction in rat skeletal muscle Takakura H et al. Scientific Reports 5 9403 2015/03
  •  Imaging mass spectrometry reveals fiber-specific distribution of acetylcarnitine and contraction-induced carnitine dynamics in rat skeletal muscles Furuichi Y et al.  Biochem Biophys Acta – Bioenergetics 1837 1699-1706 2014/10
  •  Reply to Pancheva, Panchev, and Pancheva [Letter to the editor] Yamada T et al.  JOURNAL OF APPLIED PHYSIOLOGY 115 151 2013/07
  •  Effect of spontaneous exercise on antioxidant capacity in rat muscles determined by electron spin resonance Tanabe K, Masuda K et al. Acta Physiol (Oxf) 186 2 119-125 2006/02
  •  Interaction between myoglobin and mitochondria in rat skeletal muscle Yamada T et al.  JOURNAL OF APPLIED PHYSIOLOGY 114 490-497 2013/02
  •  Role of myoglobin in regulating respiration during muscle contraction Masuda K et al.  J Phys Fitness Sports Med 2 9-16 2013/02
  •  Muscle contraction increases carnitine uptake via translocation of OCTN2 Furuichi Y et al.   Biochem Biophys Res Commun 418 774-779 2012/02
  •  Quantification of myoglobin deoxygenation and intracellular partial pressure of O2 during muscle contraction under Hb-free medium perfusion Takakura H et al. EXPERIMENTAL PHYSIOLOGY 95 5 630-640 2010/05
  •  Effects of muscle temperature on muscle oxygenation kinetics during contraction (in English) Takakura H et al. 47 11-19 2010/03
  •  OCTN2 is associated with carnitine transport capacity of rat skeletal muscles Furuichi et al.  ACTA PHYSIOLOGICA SCANDINAVICA 200 57-64 2010/09
  •  NIRS measurement of O2 dynamics in contracting blood and buffer perfused hindlimb muscle Masuda K et al. Adv Exp Med Biol 662 323-328 2010/01
  •  Effect of intensive interval training during unloading on muscle oxygenation kinetics Furuichi Y et al. INTERNATIONAL JOURNAL OF SPORTS MEDICINE 30 563-568 2009/07
  •  Histological skeletal muscle damage and surface EMG relationships following eccentric contractions Kano Y et al. J Physiol Sci 58 349-355 2008/10
  •  Determination of myoglobin concentration in blood-perfused tissue Masuda K et al. Eur J Appl Physiol 104 41-48 2008/09
  •  Proanthocyanidin promotes free radical scavenging activity in muscle tissues and plasma Masuda K et al. Appl Physiol Nutr Metab 32 1097-1104 2007/12
  •  Relationships between age, daily physical activity, antioxidant capacity and oxidative stress among middle-aged and elderly people Tanabe K et al. Int J Sport Health Sci 4 S2 515-527 2006/12
  •  Oxygen uptake kinetics following 20 days of unilateral lower limb suspension Hotta N et al. J Physiol Sci 56 5 347-353 2006/10
  •  Intensive cycle training with artificial gravity maintains muscle size and function during bed rest Akima H et al. AVIATION SPACE AND ENVIRONMENTAL MEDICINE 76 10 923-929 2005/10
  •  Antioxidant capacity in rat skeletal muscle tissues determined by electron spin resonance Masuda K et al. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY 134 2 215-220 2003/02
  •  Changes in capillary luminal diameter in rat soleus muscle after hind-limb suspension Kano Y et al. ACTA PHYSIOLOGICA SCANDINAVICA 169 271-276 2000/08
  •  Endurance training under 2500-m hypoxia does not increase myoglobin content in human skeletal muscle Masuda K et al. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY 85 486-490 2001/09
  •  Level of myoglobin concentration in human vastus lateralis muscle: effect of training status Masuda K et al. Adv Exerc Sports Physiol 7 47-51 2001/06
  •  Determinants for stair climbing by elderly from muscle morphology Percept Motor Skills 94 814-816 2002/04
  •  Statistical evaluation of endurance-training effects on systolic blood pressure in elderly people using a single-case design Int J Sport Health Sci 1 148-153 2003/03
  •  Endurance training improves muscle VO2peak but not alters tissue oxygenation level? MEDICINE AND SCIENCE IN SPORTS AND EXERCISE 35 S95 2003/06
  •  Effects of spontaneous exercise on antioxidant capacity in rat muscle determined by electron spin resonance Proceeding of Eighth Annual Congress European College Sport Science 256 2003/07
  •  Relationships between muscle strength in various isokinetic movements and kick performance among soccer players Masuda K et al. JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS 45 1 44-52 2005/03
  •  Effect of different cool-down intensity for heart contractile activity after high intensity exercise 41 1 23-34 2005/03
  •  Model evaluation of skeletal muscle deoxygenation at onset of muscle contraction Takashima T et al. 42 1 1-7 2006/03
  •  Changes in NIRS parameters and the muscle oxygenation in elder Masuda K et al. Therapeutic Res 22 1981-1985 2001/09
  •  Relationship between muscle cross-sectional area and strength in various isokinetic movements among soccer players Masuda K et al. JOURNAL OF SPORTS SCIENCES 21 10 851-858 2003/10
  •  Early phase adaptations of muscle use and strength to isokinetic training Akima et al. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE 31 588-594 1999/04
  •  Oxygen dynamics across plasma membrane during muscle contraction and implication of myoglobin contribution to oxygen transport system Takakura H et al. 46 1-12 2010/03
  •  Morphological adaptation of capillary network in compensatory hypertrophied rat plantaris muscle Kano Y et al. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY 75 97-101 1997/02
  •  Oxidative enzyme activity and soma size in motoneurons innervating the rat slow-twitch and fast-twitch muscles after chronic activity Nakano H et al. BRAIN RESEARCH BULLETIN 43 149-154 1997/02
  •  Relationships between fiber composition and NMR measurements in human skeletal muscle NMR IN BIOMEDICINE 9 8-12 1996/01
  •  Adaptation of myoglobin in compensatory hypertrophied rat muscle Masuda K et al. ACTA PHYSIOLOGICA SCANDINAVICA 160 327-331 1997/08
  •  Changes in surface EMG parameters during static and dynamic fatiguing contractions Masuda K et al. JOURNAL OF ELECTROMYOGRAPHY AND KINESIOLOGY 9 39-46 1999/01
  •  Effects of different intensity endurance training on the capillary network in rat skeletal muscle Kano et al. Int J Microcirc 17 93-96 1997/06
  •  Maintenance of myoglobin concentration in human skeletal muscle after heavy resistance training Masuda K et al. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY 79 347-352 1999/03
  •  Expression of hybrid isomyosins in human skeletal muscle AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 271 C1250-C1255 1996/10
  •  Simultaneous recording with non-invasive plethysmogram method and an invasive arterial catheter method for continuous monitoring of blood pressure variance and cardiac output variance, during exercise by ergometer Kondo S et al. 22 1 3-10 2010/04

Conference Presentations

  • Fermented grain beverage supplementation following exercise promotes glycogen supercompensation in rodent skeletal muscle and liver(2016/11/18)
  • Curcumin potentially to increase athletic performance through regulated mitochondrial biogenesis(2016/11/18)
  • Inhibition of cAMP synthesis abolish the impact of curcumin administration in rodent skeletal muscle(2016/10/04)
  • Myoglobin regulates mitochondrial respiration through its interaction with complex IV(conference:European College of Sport Science 21st Annual Congress)(2016/07)
  • Endurance training with curcumin treatment regulated mitochondrial biogenesis in skeletal muscle through SIRT1-mediated signaling pathway(conference:American College of Sports Medicine 62nd Annual Meeting)(2015/05/29)

show all

  • Curcumin decreases phosphorylation phosphodiesterase (PDE) to regulated mitochondrial biogenesis in rat skeletal muscle(conference:第70回日本体力医学会大会)(2015/09/10)
  • Myoglobin regulates mitochondrial respiration through its interaction with complex IV(conference:European College of Sport Science 21st Annual Congress)(2016/07/08)
  • Interaction of myoglobin with mitochondria in skeletal muscles(conference:European College of Sport Science 16th Annual Congress )(2011/07/06)
  • Re-assessment of myoglobin function related to muscle mitochondrial respiration(2016/08/05)
  • Mitochondrial biogenesis induced by exercise and nutriens: implication for performance and health benefits(2016/11/18)
  • Curcumin treatment augment exercise effect on mitochondria biogenesis in skeletal muscle and myocardium(conference:American College of Sports Medicine 61st Annual Meeting)(2014/06/01)
  • PGC-1α expression is not essential for endurance training–induced increase in myoglobin expression in skeletal muscle(conference: American College of Sports Medicine 61st Annual Meeting)(2014/05/30)
  • Caffeine treatment stimulates myoglobin synthesis via cAMP signaling in L6 skeletal muscle cells(conference:ACSM Conference on Integrative Physiology of Exercise)(2014/09/19)
  • New insights for the factor regulating muscle mitochondrial respiration(conference:Cell Symposia System approach to Metabolic Diseases)(2014/10/01)
  • Enhanced respiration with myoglobin interaction in mitochondria(conference:American College of Sports Medicine 61st Annual Meeting)(2014/05/30)

Arts and Fieldwork

Patent

Theme to the desired joint research

○Research for reduction of exercise-induced oxidative stress
○Development of training and conditioning methods for competitive sports

Grant-in-Aid for Scientific Research

○「骨格筋の酸素運搬と利用における骨格筋ミオグロビンの役割」(2001-2002) 
○「筋の酸素代謝能力を評価する非侵襲的手法の考案とその生理学的機構の検討」(2003-2005) 
○「筋の酸素代謝能力を評価する非侵襲的手法の考案とその生理学的機構の検討」(2004-2004) 
○「筋収縮に伴う筋細胞内外の酸素環境動態の変化と代謝動態との関連について」(2006-2007) 
○「身体不活動及び運動トレーニングが身体機能に及ぼす宇宙医学的研究」(2005-2008) 
○「酸素輸送担体に作用する骨格筋ミトコンドリアタンパク質の網羅的探索」(2013-2014) 
○「骨格筋のミトコンドリア呼吸活性を修飾する酸素輸送担体の新たな分子相互作用」(2014-2016) 
○「基質による骨格筋ミトコンドリア生合成の新たな分子機序の解明と呼吸機能評価の確立」(2015-2017) 
○「高齢者の転倒予防のための下肢筋量のガイドライン作成」(2000-2001) 
○「筋収縮時のミトコンドリア活性化に対する酸素輸送担体の分子相互作用の解明」(2011-2013) 
○「筋収縮特異的に亢進する基質流入を調節しているトランスポーターの役割」(2011-2012) 
○「筋収縮時の筋細胞内の酸素輸送担体を介した酸素輸送量と細胞呼吸の新たな連関機序」(2009-2010) 
○「ミトコンドリアに対するミオグロビンの相互作用と筋細胞内の効果的な酸素供給システム」(2008-2010) 
○「骨格筋ミトコンドリア活性を調節する酸素輸送担体の分子相互作用の解明」(2012-2014) 
○「筋収縮時における細胞内酸素ダイナミクスについて」(2010-2011) 
○「骨格筋収縮中におけるカルニチントランスポーターの活性調節機構の解明」(2010-2011) 

Classes (Bachelors)

○Health Exercise 2(2017)
○Sports Physiology (Including Exercise Physiology)(2017)
○Regional Development Studies(2017)
○Seminar in Health and Sport Sciences 1(2017)
○Seminar in Health and Sport Sciences 2(2017)
○Lecture in Biosystem and Sport(2017)
○Seminar of Graduation Thesis(2017)
○Study for Graduation Thesis(2017)
○Physiology (Including Exercise Physiology)(2017)
○Lecture in Biosystem and Sport 1(2017)
○Health Exercise(2017)
○Hygiene and Public Health 1(2017)
○Hygiene and Public Health 2(2017)
○Health Exercise 1(2017)
○Health and Sport Sciences 2(2017)
○Hygiene and Public Health(2017)
○Seminar in Health and Sport Sciences(2017)
○Regional Development Studies 2(2017)
○Seminar in Sport Physiology(2017)
○Practice in Sport Physiology(2017)
○Regional Development Studies 1(2017)
○Lecture in Biosystem and Sport 2(2017)
○Health and Sport Sciences(2017)
○Sports Physiology (Including Exercise Physiology) 1(2017)
○Hygiene and Public Health(2017)
○Health and Sport Sciences 1(2017)
○Exercise & Sports Practice(2017)
○Exercise & Sports Practice(2017)
○Sports and Exercise/Skiing(2017)
○Exercise & Sports Practice(2017)
○Exercise & Sports Practice(2017)
○Exercise & Sports Practice(2017)
○Internship in Health and Sport Sciences(2017)
○Sports Physiology (Including Exercise Physiology) 2(2017)
○Presentation and Debate (Freshman Seminar II)(2016)
○Health and Sport Sciences 1(2016)
○Hygiene and Public Health(2016)
○Seminar of Graduation Thesis(2016)
○Regional Development Studies 2(2016)
○Internship in Health and Sport Sciences(2016)
○Health and Sport Sciences 2(2016)
○Health Exercise(2016)
○Seminar in Health and Sport Sciences(2016)
○Health and Sport Sciences(2016)
○Study for Graduation Thesis(2016)
○Regional Development Studies 1(2016)
○Sports Physiology (Including Exercise Physiology)(2016)
○Regional Development Studies(2016)
○Practice in Sport Physiology(2016)
○Physiology (Including Exercise Physiology)(2016)
○Lecture in Biosystem and Sport(2016)
○Hygiene and Public Health(2016)
○Seminar in Sport Physiology(2016)
○Sports and Exercise/Skiing(2016)
○Lecture on Life in Campus and Society(2016)
○Freshman Seminar I(2016)

Classes (Graduate Schools)

○Problem Based Internship (Short Term)(2017)
○Advanced Exercise Physiology(2017)
○Advanced Exercise Physiology(2017)
○Advanced Exercise Physiology(2017)
○Advanced Exercise Physiology(2017)
○Special Study on Advanced Health Promotion Sciences 1(2017)
○Special Study on Advanced Exercise Physiology and Health Sciences(2017)
○Lectures in Leading Regional Development Studies(2017)
○Special Study on Advanced Health Promotion Sciences(2017)
○Research Seminar on Exercise and Health Promotion 1(2017)
○Special Study on Advanced Health Promotion Sciences 2(2017)
○Special Study on Advanced Exercise Physiology and Health Sciences 1(2017)
○Research Seminar on Exercise and Health Promotion(2017)
○Special Study on Advanced Exercise Physiology and Health Sciences 2(2017)
○Problem Based Internship (Long Term)(2017)
○Research Seminar on Exercise and Health Promotion 2(2017)
○Special Study on Advanced Exercise Physiology and Health Sciences 1(2016)
○Advanced Exercise Physiology(2016)
○Special Study on Advanced Health Promotion Sciences 2(2016)
○Special Study on Advanced Health Promotion Sciences 1(2016)
○Lectures in Leading Regional Development Studies(2016)
○Special Study on Advanced Exercise Physiology and Health Sciences 2(2016)
○Special Study on Advanced Health Promotion Sciences(2016)
○Research Seminar on Exercise and Health Promotion 1(2016)
○Special Study on Advanced Exercise Physiology and Health Sciences(2016)
○Problem Based Internship (Short Term)(2016)
○Research Seminar on Exercise and Health Promotion 2(2016)
○Problem Based Internship (Long Term)(2016)
○Research Seminar on Exercise and Health Promotion(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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