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研究者情報

データ更新日：2026年06月22日

材木　義隆　（ざいもく よしたか）　特任助教　ZAIMOKU, Yoshitaka

所属組織・役職等

附属病院

教育分野

所属研究室等

学歴

【取得学位】
医学博士

職歴

生年月

所属学会

学内委員会委員等

受賞学術賞

専門分野

専門分野キーワード

研究課題

著書

論文

  • A comparison of minimal residual disease detection in autografts among ASO-qPCR, droplet digital PCR, and next-generation sequencing in patients with multiple myeloma who underwent autologous stem cell transplantation.　British journal of haematology　183巻　4号　664頁　2017/12　査読有　研究論文（学術雑誌）　
  • 造血幹細胞移植後のガンマグロブリン予防投与(0.1g/kg/週)の有効性の検討:単一施設での後方視的解析　高松博幸,材木義隆,丸山裕之,細川晃平,斉藤千鶴,清木ゆう,大畑欣也,望月果奈子,小谷岳春,近藤恭夫,山崎宏人,高見昭良,中尾眞二　日本輸血細胞治療学会誌　59巻　1号　43頁　2013　査読有　
  • Human herpesvirus-8-unrelated primary effusion lymphoma of the elderly not associated with an increased serum lactate dehydrogenase level: A benign sub-group of effusion lymphoma without chemotherapy.　Leukemia & lymphoma　57巻　7号　1625頁　2016/01　査読有　研究論文（学術雑誌）　
  • Immune-Mediated Hematopoietic Failure after Allogeneic Hematopoietic Stem Cell Transplantation: A Common Cause of Late Graft Failure in Patients with Complete Donor Chimerism.　Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation　24巻　1号　43頁　2017/08　査読有　研究論文（学術雑誌）　
  • Glycosylphosphatidylinositol-specific T cells, IFN-γ-producing T cells, and pathogenesis of idiopathic aplastic anemia.　Blood　129巻　3号　388頁　2016/11　査読有　研究論文（学術雑誌）　

全て表示

  • IgM anti-recipient ABO antibodies predict acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation　International Journal of Hematology　98巻　1号　96頁　2013/07　査読有　研究論文（学術雑誌）
  • Clinical significance and origin of leukocytes that lack HLA-A allele expression in patients with acquired aplastic anemia.　Experimental Hematology　44巻　10号　931頁　2016/05　査読有　研究論文（学術雑誌）　
  • Hematopoiesis by iPSC-derived hematopoietic stem cells of aplastic anemia that escape cytotoxic T-cell attack.　Blood advances　2巻　4号　390頁　2018/02/27　査読有　研究論文（学術雑誌）　
  • Identification of an HLA class I allele closely involved in the autoantigen presentation in acquired aplastic anemia.　Blood　129巻　21号　2908頁　2017/02　査読有　研究論文（学術雑誌）　
  • Cyclosporine restores hematopoietic function by compensating for decreased Tregs in patients with pure red cell aplasia and acquired aplastic anemia.　Annals of Hematology　95巻　5号　771頁　2016/03　査読有　研究論文（学術雑誌）　
  • Hypomegakaryocytic thrombocytopenia (HMT): an immune-mediated bone marrow failure characterized by an increased number of PNH-phenotype cells and high plasma thrombopoietin levels.　British Journal of Haematology　175巻　2号　246頁　2016/06　査読有　研究論文（学術雑誌）　
  • 3D CNN-based Deep Learning Model-based Explanatory Prognostication in Patients  with Multiple Myeloma using Whole-body MRI.　Journal of medical systems　48巻　1号　30頁　2024/03/08　査読有　研究論文（学術雑誌）　
  • HLA class I allele-lacking leukocytes predict rare clonal evolution to MDS/AML in patients with acquired aplastic anemia.　Blood　137巻　25号　3576頁　2021/06/24　査読有　研究論文（学術雑誌）　
  • HLA Class I Allele Loss and Bone Marrow Transplantation Outcomes in Immune Aplastic Anemia　Transplantation and Cellular Therapy　30巻　3号　281.e1-281.e13頁　2024/03　査読有　研究論文（学術雑誌）
  • Evaluation of a biosimilar granulocyte colony-stimulating factor for peripheral blood stem cell mobilization in Japanese healthy donors: a prospective study.　International Journal of Hematology　110巻　6号　648頁　2019/09　査読有　研究論文（学術雑誌）　
  • Sustained clonal hematopoiesis by HLA-lacking hematopoietic stem cells without driver mutations in aplastic anemia.　Blood Advances　2巻　9号　1000頁　2018/05/08　査読有　研究論文（学術雑誌）　
  • Escape hematopoiesis by HLA-B5401-lacking hematopoietic stem progenitor cells in men with acquired aplastic anemia.　Haematologica　104巻　10号　e447頁　2019/03　査読有　研究論文（学術雑誌）　
  • Predicting response of severe aplastic anemia to immunosuppression combined with eltrombopag.　Haematologica　107巻　1号　126頁　2021/04　査読有　研究論文（学術雑誌）　
  • Culture-negative infective endocarditis due to Neisseria bacilliformis identified via 16S rRNA gene analysis from resected valve tissue: Case report and review of the literature.　Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy　31巻　2号　102502頁　2025/02　査読有　研究論文（学術雑誌）
  • Significance of absolute neutrophil count before allogeneic hematopoietic stem cell transplantation in adult patients with aplastic anemia.　Annals of hematology　103巻　8号　3121頁　2024/08　査読有　研究論文（学術雑誌）
  • Frequent loss of HLA-B*40:02 from leucocytes in male patients with hepatitis-associated aplastic anaemia.　British journal of haematology　205巻　5号　2084頁　2024/11　査読有　研究論文（学術雑誌）　
  • Minor GPI(-) granulocyte populations in aplastic anemia and healthy individuals derived from a few PIGA-mutated hematopoietic stem progenitor cells.　Blood cancer journal　13巻　1号　165頁　2023/11/08　査読有
  • Familial immune-mediated aplastic anaemia in six different families.　EJHaem　4巻　3号　714頁　2023/08　査読有　研究論文（学術雑誌）　
  • The effectiveness of immunosuppressive therapy in patients with aplastic anaemia secondary to chemoradiotherapy for cancers　British Journal of Haematology　195巻　5号　770頁　2021/12　査読有　研究論文（学術雑誌）
  • Late graft failure with donor-derived GPI-deficient cells in a mixed chimera following allogeneic bone marrow transplantation for severe aplastic anemia.　Bone marrow transplantation　58巻　4号　465頁　2023/04　査読有　研究論文（学術雑誌）
  • Deficit of circulating CD19+ CD24hi CD38hi regulatory B cells in severe aplastic anaemia.　British Journal of Haematology　190巻　4号　610頁　2020/04　査読有　研究論文（学術雑誌）　
  • Single-cell analysis of aplastic anemia reveals a convergence of NK and NK-like CD8+ T cells with a disease-associated TCR signature.　Science translational medicine　17巻　787号　eadl6758頁　2025/02/26　査読有　研究論文（学術雑誌）
  • Haematopoietic regeneration by HLA-A*0206-deficient clones in severe aplastic anaemia without definitive immunosuppressive treatment.　British journal of haematology　205巻　5号　1995頁　2024/11　査読有　研究論文（学術雑誌）　
  • A Japanese Case of COVID-19 Caused by Omicron Strain with Y453F Substitution.　Rinsho Biseibutsu Jinsoku Shindan Kenkyukai shi = JARMAM : Journal of the Association for Rapid Method and Automation in Microbiology　33巻　1号　19頁　2023/12/26　査読有　研究論文（学術雑誌）
  • Comparison of Haploidentical Stem Cell Transplantation with Post-Transplantation Cyclophosphamide versus Umbilical Cord Blood Transplantation in Adult Patients with Aplastic Anemia.　Transplantation and cellular therapy　29巻　12号　766.e1-766.e8頁　2023/12　査読有　研究論文（学術雑誌）
  • Systematic active environmental surveillance successfully identified and controlled the Legionella contamination in the hospital.　Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy　29巻　1号　43頁　2023/01　査読有　研究論文（学術雑誌）
  • Predictors of clonal evolution and myeloid neoplasia following immunosuppressive therapy in severe aplastic anemia.　Leukemia　36巻　9号　2328頁　2022/09　査読有　研究論文（学術雑誌）
  • Frequent HLA-DR loss on hematopoietic stem progenitor cells in patients with cyclosporine-dependent aplastic anemia carrying HLA-DR15.　Leukemia　36巻　6号　1666頁　2022/06　査読有　研究論文（学術雑誌）
  • HLA associations, somatic loss of HLA expression, and clinical outcomes in immune aplastic anemia　Blood　138巻　26号　2799頁　2021/12/30　査読有　研究論文（学術雑誌）
  • A frequent nonsense mutation in exon 1 across certain HLA-A and -B alleles in leukocytes of patients with acquired aplastic anemia.　Haematologica　106巻　6号　haematol.2020.247809頁　2021/06　査読有　研究論文（学術雑誌）　
  • Phase II study of the triple combination of rabbit ATG, ciclosporin and eltrombopag in patients with transfusion-dependent aplastic anaemia: West Japan Hematology Study Group (W-JHS) AA02 trial.　British journal of haematology　2026/01/04　査読有　研究論文（学術雑誌）
  • Infection in glaucoma drainage implant caused by macrolide-resistant Mycobacterium abscessus subsp. abscessus.　Diagnostic microbiology and infectious disease　113巻　4号　117060頁　2025/12　査読有　研究論文（学術雑誌）
  • Interferon-γ-mediated selective inhibition of hematopoiesis and the clonal advantage of HLA-lacking hematopoietic stem progenitor cells in aplastic anemia.　Leukemia　39巻　6号　1490頁　2025/06　査読有　研究論文（学術雑誌）
  • Loss‐Prone HLA Class I Alleles Inform Outcomes of Early Hematopoietic Cell Transplantation in Acquired Aplastic Anemia　American Journal of Hematology　2025/12　査読有　研究論文（学術雑誌）
  • Prevalence and outcome of VEXAS syndrome in unrelated hematopoietic cell transplantation for bone marrow failure.　Clinical and experimental medicine　25巻　1号　300頁　2025/08/22　査読有　研究論文（学術雑誌）
  • The contribution of metagenomic next-generation sequencing to a diagnosis of gas-producing Fusobacterium-induced septic hip arthritis: A case report.　Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy　31巻　4号　102681頁　2025/04　査読有　研究論文（学術雑誌）
  • Pediatric pneumonia involving Penicillium rolfsii isolated from sputum culture following a plunge pool near-drowning incident.　Journal de mycologie medicale　35巻　4号　101589頁　2025/12　研究論文（学術雑誌）
  • Case Report: Spontaneous Remission of Severe Aplastic Anemia Mediated by Mutant Hematopoietic Stem Cells Evading T-cell Attack　Kohei Shiroshita,Yoshitaka Zaimoku,Himari Kudo,Naoshi Obara,Kazuyoshi Hosomichi,Yui Kano,Miku Kobayashi,Eriko Morishita,Hiroyuki Takamatsu,Takaaki Toyama,Shinji Nakao　Frontiers in Immunology　2025/09　査読有　研究論文（学術雑誌）
  • iPSC-derived modeling of HLA-lacking hematopoiesis reveals clonal diversity in eltrombopag response in acquired aplastic anemia.　Stem cells (Dayton, Ohio)　2026/01/24　研究論文（学術雑誌）
  • Transient lupus anticoagulant induced by adenovirus cystitis in a bone marrow transplant recipient.　International journal of hematology　2025/06/05　査読有　研究論文（学術雑誌）

講演・口頭発表等

  • Prevalence, clinical features, and outcomes of VEXAS syndrome in hematology clinic(会議名：日本血液学会学術集会)(2025/10)
  • Role of HLA in AA(会議名：8th International Bone Marrow Failure Disease Scientific Symposium)(2022/05/19)
  • HLA Class I Allele-Deficient Clones Enable Durable Hematopoietic Regeneration without Anti-Thymocyte Globulin in Immune Aplastic Anemia(会議名：2nd Asian Bone Marrow Failure Symposium, Seoul, Korea)(2026/01/17)
  • Multiple HLA-loss clones are required for hematologic regeneration in immune aplastic anemia(会議名：67TH ASH ANNUAL MEETING AND EXPOSITION)(2025/12/06)
  • 教育講演：再生不良性貧血におけるHLA欠失(会議名：第87回日本血液学会学術集会)(2025/10/10)

全て表示

  • Immune escape and hematopoietic regeneration in aplastic anemia(会議名：1st Asian Bone Marrow Failure Symposium. Seoul, Korea.)(2025/01/17)
  • The Copy Number of Disease-Associated HLA Alleles Predicts the Response to Immunosuppressive Therapy in Acquired Aplastic Anemia(会議名：63rd ASH Annual Meeting and Exposition)(2021/12/13)
  • HLA Clonality in Aplastic Anemia(会議名：10th International Bone Marrow Failure Disease Scientific Symposium. Bethesda, MD, USA.)(2026/03/19)

その他（報告書など）

芸術・フィールドワーク

特許

○ヒト抗HLAモノクローナル抗体の作製方法(出願国名：国内,外国,特許協力条約より出願)(特許番号：特許6952295)

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