Assistant Professor NAGAYA Satomi
Faculty, Affiliation
Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences
College and School Educational Field
Division of Health Sciences, Graduate School of Medical Science
Department of Laboratory Sciences，School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences
Laboratory
Academic Background
Career
Asanogawa General Hospital(2010/04/01-2020/03/31)
Department of Clinical Laboratory Science, Division of Health Sciences, Graduate School of Medical Science, Kanazawa University(2020/04/01-)
Year & Month of Birth
Academic Society
日本血栓止血学会
Award
Specialities
Laboratory medicine、Hematology
Speciality Keywords
laboratory hematology, thrombosis and hemostasis, inherited thrombophilia
Research Themes
Molecular analysis of thrombus formation mechanism by abnormal prothrombin with thrombomodulin binding disorder
Pathophysiology of inherited thrombophilia
Clarification of factors affecting protein S activity
Books
- Satomi Nagaya, Eriko Morishita Clinically Oriented Thrombosis and Hemostasis, Revised 3rd Edition Chugai Igakusha 2024/06/13
Papers
- Genetic variability in SARS-CoV-2 vaccine response: association of rs3824949 in TRIM5 with antibody titers in a Japanese cohort Nagaya S, Nguyen HTG, Espinoza JL, Yamaguchi K, Goto K, Horiuchi H, Morishita E Laboratory Medicine International 4 4 2025/12/01
- Optimizing blood collection and storage conditions for soluble C-type lectin-like receptor 2 measurement and evaluating diurnal variation Yamaguchi K & Nagaya S, Matsui A, Togashi T, Iritani K, Sato S, Kawamura M, Matsushita S, Furuyama H, Yamaguchi Y, Morishita E Laboratory Medicine International 2025/11/10
- Tissue Factor Pathway-Driven Initial Thrombin Generation is Associated with Hypercoagulability in Obesity Kamikubo Y, Nagaya S, Inoue R, Yamaguchi K, Morimoto-Kamata R, Morishita E, Samad F, Ohkura N, Inoue K Thromb Haemost 2025/03/31
- Functional characterization of two protein C variants causing type I deficiency via cellular degradation or retention Yasuda I & Nagaya S, Kikuchi Y, Yui R, Kuwajima Y, Morishita E Int J Hematol 2025/09/11
- A case of venous thromboembolism caused by protein C deficiency due to a novel gene mutation Noiri J, Matsuzoe H, Nagaya S, Nishio R, Matsumoto D, Takaishi H, Morishita E. J Cardiol Cases 26 5 360-363 2022/08/12
- Identification of two de novo variants causing inherited antithrombin deficiency by quantitative analysis of variant alleles Togahi T & Nagaya S, Meguro-Horike M, Matsumoto H, Imai Y, Yamaguchi K, Fujii Y, Moriya H, Kikuchi Y, Yasuda I, Horike SI, Morishita E. Thromb Res 233 37-40 2023/11/20
- First report of inherited protein S deficiency caused by paternal PROS1 mosaicism Nagaya S & Maruyama K, Watanabe A, Meguro-Horike M, Imai Y, Hiroshima Y, Horike SI, Kokame K, Morishita E. Haematologica 107 1 330-333 2021/10/14
- Effect on plasma protein S activity in patients receiving the factor Xa inhibitors Terakami T & Nagaya S , Hayashi K, Furusho H, Fujino N, Kato T, Asakura H, Morishita E. J Atherosclerosis Thromb 29 7 1059-1068 2021/07/30
- Protein C gene mutation in an older adult patient with clostridium perfringens septicemia-related visceral vein thrombosis Kanosue K,Nagaya S, Morishita E, Yamanishi M, Imashuku S. TH Open 5 2 171-173 2021/05/26
- Protein S deficiency caused by cryptic splicing due to the novel intron variant c.346+5G>C in PROS1 Nagaya S & Togashi T & Akiyama M, Imai Y, Matsumoto H, Moriya H, Meguro-Horike M, Yasuda I, Kikuchi Y, Kuwajima Y, Horike SI, Watanabe A, Morishita E Thromb Res 229 26-30 2023/06/28
- Effect of antithrombin leakage from hemodialysis therapy on antithrombin hemodynamics Fujii Y, Nagaya S, Seo A, Kanazawa Y, Oba T, Morishita E Cureus 16 12 e75117 2024/12/04
- Congenital coagulation factor X deficiency: Genetic analysis of five patients and functional characterization of mutant factor X proteins Nagaya S, Akiyama M, Murakami M, Sekiya A, Asakura H, Morishita E. Haemophilia 24 5 774-785 2018/09/01
- Molecular genetic analysis of inherited protein C deficiency caused by the novel large deletion across two exons of PROC Togashi T, Meguro-Horike M, Nagaya S, Sugihara S, Ichinose T, Araiso Y, Yamaguchi K, Mori K, Imai Y, Kuzasa K, Horike SI, Asakura H, Morishita E. Thromb Res 188 115-118 2020/04/01
- Molecular mechanism underlying functional defects in the prothrombin variant Segovia that cause a bleeding tendency Kuwajima Y & Nagaya S, Kikuchi Y, Yasuda I, Kamikubo Y, Morishita E Haemophilia 2025/09/05
- Identification and functional analysis of three novel genetic variants resulting in premature termination codons in three unrelated patients with hereditary antithrombin deficiency Imai Y, Nagaya S, Araiso Y, Meguro-Horike M, Togashi T, Ohmori K, Makita Y, Sato E, Yujiri T, Nagamori Y, Horike SI, Watanabe A, Morishita E. Int J Hematol 117 4 523-529 2022/12/16
- Functional analysis of two abnormal antithrombin proteins with different intracellular kinetics Imai Y, Nagaya S, Araiso Y, Meguro-Horike M, Togashi T, Horike SI, Kawasaki H, Morishita E. Thromb Res 230 18-26 2023/10/01
- A case of factor X (FX) deficiency due to novel mutation V196M, FX Hofu Shinohara K, Adachi M, Matsui K, Matsuda K, Nagaya S, Morishita E. Int J Hematol 87 3 256-259 2008/04/01
- Genetic analysis of a compound heterozygous patient with congenital factor X deficiency and regular replacement therapy with a prothrombin complex concentrate Togashi T, Nagaya S, Nagasawa M, Meguro-Horike M, Nogami K, Imai Y, Kuzasa K, Sekiya A, Horike SI, Asakura H, Morishita E. Int J Hematol 111 1 51-56 2020/01/01
- Evaluation of Optimal Sample Processing Conditions for Accurate Measurement of Protein S Activity Nagaya S, Araiso Y, Yamaguchi K, Omote Y, Matsui A, Asakura H, Morishita E. Ann Clin Lab Sci 51 2 206-212 2021/03/31
- A case of treatment with dabigatran for cerebral venous thrombosis caused by hereditary protein C deficiency Fukushima T, Shimomura Y, Nagaya S, Morishita E, Kawakami O. Cureus 13 6 e15473 2021/06/06
- Loss of von Willebrand factor large multimers in patients undergoing hemodialysis: A single-center, retrospective study Fujii Y & Nagaya S, Kanno T, Yamada S, Suzuki M, Goto K, Horiuchi H, Matsumoto M, Morishita E Thromb Res 249 109316 2025/04/02
- The novel protein C variant p.C101F results in early intracellular degradation that drives type I protein C deficiency Yui R & Nagaya S, Yasuda I, Togashi T, Kikuchi Y, Saito K, Meguro‐Horike M, Horike SI, Kawasaki H, Nishikii H, Morishita E Int J Hematol 121 6 774-781 2025/02/10
- Mechanism of antithrombin deficiency due to the novel variant C32W in the C-terminus of the signal peptide Kikuchi Y & Nagaya S, Togashi T, Imai Y, Togashi M, Araiso Y, Nishiuchi T, Morishita E Int J Hematol 122 1 35-44 2025/02/10
Conference Presentations
- Phospholipid binding analysis of prothrombin variants using high-speed atomic force microscopy(conference：The 33rd Congress of the International Society on Thrombosis and Haemostasis)(2025/06/24)
- The Role of BMAL1 in Endothelial Cell Function in Vascular Endothelial Cells(conference：The 46th Annual Meeting of the Japanese Society on Thrombosis and Hemostasis)(2024/06/13)
- The Role of TFPI in Vivo: Regulation and Control Mechanisms of Blood Coagulation(conference：All Hemophilia Clinical Conference in Hokuriku)(2024/11/21)
- Effects of Anticoagulants on the Activities of Coagulation Regulatory Factors(conference：The 19th Japanese Society on Thrombosis and Hemostasis Scientific Standardization Committee Symposium)(2025/02/15)
Others
- Molecular Mechanisms and Pathophysiology of Congenital Protein C Deficiency/Dysfunction Satomi Nagaya, Eriko Morishita Journal of the Japanese Society on Thrombosis and Hemostasis 35 5 589 2024/10/01
- Novel Therapeutic Strategies for Hereditary Thrombophilia Satomi Nagaya, Eriko Morishita Hematology 90 2 177 2025/02/28
- The measurements of anti-cardiolipin IgG/IgM antibody and anti-β2GP I IgG/IgM antibody Satomi Nagaya, Eriko Morishita 67 3 146 2021/03/01
- Changes in coagulation and fibrinolytic factors and molecular markers during pregnancy Satomi Nagaya, Eriko Morishita Kensa to Gizyutsu 50 1 20 2022/01/01
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「異常トロンビンのトロンボモジュリンまたはPAR-1を介した血栓形成メカニズムの解明」(2024-2025)
○「Analysis of the mechanism of thrombogenesis mediated by thrombomodulin or PAR-1 of abnormal thrombin」(2022-2023)
○Research Activity start-up「異常プロトロンビンのトロンボモジュリン抵抗性による血栓症発症機序の解明」(2021-2021)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Experimental Course of Clinical Physiology II(2023)
○Clinial Practice of Hematology and Blood Transfusion(2023)
○Clinial Practice of Clinical Physiology(2023)
○Laboratory Information Management(2023)
○Hematology(2023)
○Experimental Course of Clinical Physiology II(2023)
○Laboratory Information Management(2023)
○Clinial Practice of Hematology and Blood Transfusion(2023)
○Clinial Practice of Clinical Physiology(2023)
○Hematology(2023)
○Practice in Laboratory Hematology(2023)
○Presentation and Debate(2023)
○Practice in Laboratory Hematology(2023)
○Physiology(2023)
○Physiology(2023)
○Academic Skill(2023)
○Introduction to Region-studies(2023)
○Laboratory Hematology(2022)
○Experimental Course of Clinical Physiology II(2022)
○Clinial Practice of Clinical Physiology(2022)
○Clinial Practice of Hematology and Blood Transfusion(2022)
○Laboratory Information Management(2022)
○Experimental Course of Clinical Physiology II(2022)
○Clinial Practice of Hematology and Blood Transfusion(2022)
○Laboratory Information Management(2022)
○Clinial Practice of Clinical Physiology(2022)
○Laboratory Hematology(2022)
○Experimental Course in Physiology(2022)
○Practice in Laboratory Hematology(2022)
○Clinical Physiology 2(2022)
○Practice in Laboratory Hematology(2022)
○Human Physiology(2022)
○Human Physiology(2022)
○Experimental Course in Physiology(2022)
○Clinical Physiology 2(2022)
○Experimental Course in Physiology(2022)
○Practice in Laboratory Hematology(2022)
○Human Physiology(2022)
○Public Health(2021)
○Practice in Laboratory Hematology(2021)
○Human Physiology(2021)
○Laboratory Hematology(2021)
○Clinial Practice of Clinical Physiology(2021)
○Clinical Physiology II(2021)
○Clinial Practice of Hematology and Blood Transfusion(2021)
○Experimental Course of Clinical Physiology II(2021)
○Clinical Physiology I(2020)
○Laboratory Hematology(2020)
○Clinical Physiology II(2020)
○Experimental Course of Clinical Physiology II(2020)
○Practice in Laboratory Hematology(2020)
○Experimental Course in Physiology(2020)
○Public Health(2020)
○Human Physiology(2020)
○Clinial Practice of Hematology and Blood Transfusion(2020)
○Clinial Practice of Clinical Physiology(2020)
Classes (Graduate Schools)
○Clinical Immunohematology: Seminar(2023)
○Clinical Immunohematology: Seminar(2023)
○Clinical Immunohematology: Seminar(2023)
○Clinical Immunohematology: Seminar(2023)
○Laboratory Rotation Ⅱ(2023)
○Laboratory Rotation Ｉ(2023)
○Clinical Immunohematology: Lecture(2023)
○Clinical Immunohematology: Lecture(2023)
○An Introduction to Medical Laboratory Sciences:Lec(2023)
○An Introduction to Medical Laboratory Sciences:Lec(2023)
○Laboratory Rotation Ⅱ(2023)
○Laboratory Rotation Ｉ(2023)
○Clinical Immunohematology: Lecture(2023)
○Clinical Immunohematology: Lecture(2023)
○Laboratory RotationⅠ(2023)
○Laboratory RotationⅠ(2023)
○Laboratory RotationⅠ(2023)
○Laboratory Rotation I(2023)
○Laboratory Rotation I(2023)
○Clinical Immunohematology: Seminar(2022)
○Clinical Immunohematology: Seminar(2022)
○An Introduction to Medical Laboratory Sciences:Lec(2022)
○Clinical Immunohematology: Lecture(2022)
○Clinical Immunohematology: Lecture(2022)