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Researcher Information

last modified：2024/11/22

Professor　WADA Taizo

Laboratory Website

Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field

Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

　TEL:076-265-2313　FAX:076-262-1866

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University　Doctor　Graduate School, Division of Medicine　199703　Completed
【Academic background(Bachelor's Degree)】
Kanazawa University　199203
【Degree】
PhD

Career

1999-2002 National Institutes of Health Visiting Fellow

Year & Month of Birth

Academic Society

Award

○JSPS Research Fellowships for Japanese Biomedical and Behavioral Researchers at NIH(2001/01)
○2002 Fellows Award for Research Excellence (NIH)(2002)
○Juzen Medical Award(2008/11)
○Juzen Medical Award(2008/11)
○Juzen Medical Award(2008/11)

Specialities

Speciality Keywords

pediatrics, clinical immunology

Research Themes

Ontogeny of immune system and its abnormality

Pathogenesis of EBV-associated lymphoproliferative diseases

Books

Papers

  • 　Characterization of skin blister fluids from children with Epstein–Barr virus-associated lymphoproliferative disease　Taizo Wada,Tomoko Toma,Hanae Miyazawa,Eiko Koizumi,Tetsujiro Shirahashi,Yusuke Matsuda,Akihiro Yachie　Journal of Dermatology　45　4　444　2018/04/01
  • 　Flow cytometry-based diagnosis of primary immunodeficiency diseases　Hirokazu Kanegane,Akihiro Hoshino,Tsubasa Okano,Takahiro Yasumi,Taizo Wada,Hidetoshi Takada,Satoshi Okada,Motoi Yamashita,Tzu-wen Yeh,Ryuta Nishikomori,Masatoshi Takagi,Kohsuke Imai,Hans D. Ochs,Tomohiro Morio　Allergology International　67　1　43　2018/01/01
  • 　XL-EDA-ID Presenting with Congenital Duodenal Atresia and Perforations.　Mitani Y,Wada T,Matsuda Y,Sakai S,Yachie A　Journal of clinical immunology　38　7　733　2018/08
  • 　Human CTL-based functional analysis shows the reliability of a munc13-4 protein expression assay for FHL3 diagnosis.　Hirofumi Shibata,Takahiro Yasumi,Saeko Shimodera,Eitaro Hiejima,Kazushi Izawa,Tomoki Kawai,Ryutaro Shirakawa,Taizo Wada,Ryuta Nishikomori,Hisanori Horiuchi,Osamu Ohara,Eiichi Ishii,Toshio Heike　Blood　131　18　2016　2018/05/03
  • 　Longitudinal analysis of serum interleukin-18 in patients with familial Mediterranean fever carrying MEFV mutations in exon 10　Taizo Wada,Tomoko Toma,Hanae Miyazawa,Eiko Koizumi,Tetsujiro Shirahashi,Yusuke Matsuda,Akihiro Yachie　Cytokine　104　143　2018/04/01

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  • 　Collagen adhesion gene is associated with bloodstream infections caused by methicillin-resistant Staphylococcus aureus.　Yasunori Iwata,Kenji Satou,Kengo Furuichi,Ikuko Yoneda,Takuhiro Matsumura,Masahiro Yutani,Yukako Fujinaga,Atsushi Hase,Hidetoshi Morita,Toshiko Ohta,Yasuko Senda,Yukiko Sakai-Takemori,Taizo Wada,Shinichi Fujita,Taito Miyake,Haruka Yasuda,Norihiko Sakai,Shinji Kitajima,Tadashi Toyama,Yasuyuki Shinozaki,Akihiro Sagara,Taro Miyagawa,Akinori Hara,Miho Shimizu,Yasutaka Kamikawa,Kazuho Ikeo,Shigeyuki Shichino,Satoshi Ueha,Takuya Nakajima,Kouji Matsushima,Shuichi Kaneko,Takashi Wada　International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases　91　22　2020/02
  • 　Novel HAX1 Gene Mutation in a Vietnamese Boy with Severe Congenital Neutropenia.　Tran TT,Vu QV,Wada T,Yachie A,Le Thi Minh H,Nguyen SN　Case reports in pediatrics　2018　2798621　2018
  • 　Downregulation of CD5 and dysregulated CD8+ T-cell activation.　Wada T　Pediatrics international : official journal of the Japan Pediatric Society　60　9　776　2018/09
  • 　Enhanced AKT Phosphorylation of Circulating B Cells in Patients With Activated PI3Kδ Syndrome.　Takaki Asano,Satoshi Okada,Miyuki Tsumura,Tzu-Wen Yeh,Kanako Mitsui-Sekinaka,Yuki Tsujita,Youjiro Ichinose,Akira Shimada,Kunio Hashimoto,Taizo Wada,Kohsuke Imai,Osamu Ohara,Tomohiro Morio,Shigeaki Nonoyama,Masao Kobayashi　Frontiers in immunology　9　568　2018
  • 　C/EBPε ΔRS derived from a neutrophil-specific granule deficiency patient interacts with HDAC1 and its dysfunction is restored by trichostatin A.　Muraoka M,Akagi T,Ueda A,Wada T,Koeffler HP,Yokota T,Yachie A　Biochemical and biophysical research communications　516　1　293　2019/08
  • 　Hematopoietic stem cell transplantation for progressive combined immunodeficiency and lymphoproliferation in patients with activated phosphatidylinositol-3-OH kinase δ syndrome type 1.　Tsubasa Okano,Kohsuke Imai,Yuki Tsujita,Noriko Mitsuiki,Kenichi Yoshida,Chikako Kamae,Kenichi Honma,Kanako Mitsui-Sekinaka,Yujin Sekinaka,Tamaki Kato,Katsuyuki Hanabusa,Eri Endo,Takehiro Takashima,Haruka Hiroki,Tzu-Wen Yeh,Keisuke Tanaka,Masakazu Nagahori,Ikuya Tsuge,Yuki Bando,Fuminori Iwasaki,Yoshiaki Shikama,Masami Inoue,Tomiko Kimoto,Naohiko Moriguchi,Yuki Yuza,Takashi Kaneko,Kyoko Suzuki,Tomoyo Matsubara,Yoshihiro Maruo,Tomoaki Kunitsu,Tomoko Waragai,Hideki Sano,Yuko Hashimoto,Kazuhiro Tasaki,Osamu Suzuki,Toshihiko Shirakawa,Motohiro Kato,Toru Uchiyama,Masataka Ishimura,Tetsuzo Tauchi,Hiroshi Yagasaki,Shiann-Tarng Jou,Hsin-Hui Yu,Hirokazu Kanegane,Sven Kracker,Anne Durandy,Daiei Kojima,Hideki Muramatsu,Taizo Wada,Yuzaburo Inoue,Hidetoshi Takada,Seiji Kojima,Seishi Ogawa,Osamu Ohara,Shigeaki Nonoyama,Tomohiro Morio　The Journal of allergy and clinical immunology　143　1　266　2019/01
  • 　Apoptosis inhibitor of macrophage as a biomarker for disease activity in Japanese children with IgA nephropathy and Henoch-Schönlein purpura nephritis.　Hitoshi Irabu,Masaki Shimizu,Shuya Kaneko,Natsumi Inoue,Mao Mizuta,Yuko Tasaki,Kazuhide Ohta,Akihiro Yachie,Taizo Wada　Pediatric research　89　3　667　2020/05/14
  • 　High-throughput analysis revealed the unique immunoglobulin gene rearrangements in plasmacytoma-like post-transplant lymphoproliferative disorder.　Akihiro Hoshino,Akira Nishimura,Takuya Naruto,Tsubasa Okano,Kazuaki Matsumoto,Keisuke Okamoto,Hiroshi Shintaku,Shown Tokoro,Hiroyuki Okamoto,Taizo Wada,Masatoshi Takagi,Kohsuke Imai,Hirokazu Kanegane,Tomohiro Morio　British journal of haematology　189　4　e164-e168　2020/05
  • 　The increased frequency of methicillin-resistant Staphylococcus aureus with low MIC of beta-lactam antibiotics isolated from hospitalized patients.　Yasunori Iwata,Norihiko Sakai,Ikuko Yoneda,Kenji Satou,Kengo Furuichi,Yasuko Senda,Yukiko Sakai-Takemori,Taizo Wada,Shinichi Fujita,Hisahiro Ogura,Kouichi Sato,Taichiro Minami,Kaori Yamaguchi,Shinji Kitajima,Tadashi Toyama,Yuta Yamamura,Taro Miyagawa,Akinori Hara,Miho Shimizu,Yoshio Sakai,Kazuho Ikeo,Shigeyuki Shichino,Satoshi Ueha,Takuya Nakajima,Kouji Matsushima,Takashi Wada　Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy　26　6　604　2020/06
  • 　Hematopoietic stem cell transplantation for progressive combined immunodeficiency and lymphoproliferation in patients with activated phosphatidylinositol-3-OH kinase δ syndrome type 1.　Okano T, Imai K, Tsujita Y, Mitsuiki N, Yoshida K, Kamae C, Honma K, Mitsui-Sekinaka K, Sekinaka Y, Kato T, Hanabusa K, Endo E, Takashima T, Hiroki H, Yeh TW, Tanaka K, Nagahori M, Tsuge I, Bando Y, Iwasaki F, Shikama Y, Inoue M, Kimoto T, Moriguchi N, Yuza Y, Kaneko T, Suzuki K, Matsubara T, Maruo Y, Kunitsu T, Waragai T, Sano H, Hashimoto Y, Tasaki K, Suzuki O, Shirakawa T, Kato M, Uchiyama T, Ishimura M, Tauchi T, Yagasaki H, Jou ST, Yu HH, Kanegane H, Kracker S, Durandy A, Kojima D, Muramatsu H, Wada T, Inoue Y, Takada H, Kojima S, Ogawa S, Ohara O, Nonoyama S, Morio T.　J Allergy Clin Immunol　143　1　266-275　2019/01
  • 　Novel HAX1 Gene Mutation in a Vietnamese Boy with Severe Congenital Neutropenia.　Tran TT, Vu QV, Wada T, Yachie A, Le Thi Minh H, Nguyen SN.　Case Rep Pediatr　2798621　2018
  • 　XL-EDA-ID Presenting with Congenital Duodenal Atresia and Perforations.　Mitani Y, Wada T, Matsuda Y, Sakai S, Yachie A.　J Clin Immunol　38　7　733-735　2018
  • 　Downregulation of CD5 and dysregulated CD8+ T-cell activation.　Wada T.　Pediatr Int　60　9　776-780　2018
  • 　Human CTL-based functional analysis shows the reliability of a munc13-4 protein expression assay for FHL3 diagnosis.　Shibata H, Yasumi T, Shimodera S, Hiejima E, Izawa K, Kawai T, Shirakawa R, Wada T, Nishikomori R, Horiuchi H, Ohara O, Ishii E, Heike T.　Blood　131　18　2016-2025　2018
  • 　Enhanced AKT Phosphorylation of Circulating B Cells in Patients With Activated PI3Kδ Syndrome.　Asano T, Okada S, Tsumura M, Yeh TW, Mitsui-Sekinaka K, Tsujita Y, Ichinose Y, Shimada A, Hashimoto K, Wada T, Imai K, Ohara O, Morio T, Nonoyama S, Kobayashi M.　Front Immunol　9　568　2018
  • 　Characterization of skin blister fluids from children with Epstein-Barr virus-associated lymphoproliferative disease.　Wada T, Toma T, Miyazawa H, Koizumi E, Shirahashi T, Matsuda Y, Yachie A.　J Dermatol　45　4　444-449　2018
  • 　Longitudinal analysis of serum interleukin-18 in patients with familial Mediterranean fever carrying MEFV mutations in exon 10.　Wada T, Toma T, Miyazawa H, Koizumi E, Shirahashi T, Matsuda Y, Yachie A.　Cytokine　104　143-146　2018
  • 　Flow cytometry-based diagnosis of primary immunodeficiency diseases.　Kanegane H, Hoshino A, Okano T, Yasumi T, Wada T, Takada H, Okada S, Yamashita M, Yeh TW, Nishikomori R, Takagi M, Imai K, Ochs HD, Morio T.　Allergol Int　67　1　43-54　2018/01
  • 　The down-regulation of two component system and cell wall biosynthesis related genes was associated with the reversion to daptomycin (DAP) susceptibility in DAP non-susceptible methicillin-resistant Staphylococcus aureus.　Iwata Y, Satou K, Tsuzuku H, Furuichi K, Senda Y, Sakai-Takemori Y, Wada T, Fujita S, Miyake T, Yasuda H, Sakai N, Kitajima S, Toyama T, Shinozaki Y, Sagara A, Miyagawa T, Hara A, Shimizu M, Kamikawa Y, Kaneko S, Wada T.　Eur J Clin Microbiol Infect Dis　36　10　1839-1845　2017/10
  • 　Peripheral blood plasmacytosis in severe fever with thrombocytopenia syndrome.　Wada T, Iwata Y, Kamikawa Y, Wada T, Yachie A.　Jpn J Infect Dis　70　4　470-471　2017
  • 　Prolonged neutropenia due to antihuman neutrophil antigen 2 (CD177) antibody after bone marrow transplantation.　Wada T, Miyamoto S, Okamoto H, Matsuda Y, Toma T, Imai K, Takagi M, Morio T, Yachie A.　Pediatr Blood Cancer　64　7　e26388　2017
  • 　Role of the Leucine Zipper Domain of CCAAT/Enhancer Binding Protein-Epsilon (C/EBPε) in Neutrophil-Specific Granule Deficiency　Wada T, Akagi T.　Crit Rev Immunol　36　4　349-358　2016/12
  • 　Elevation of fecal eosinophil-derived neurotoxin in infants with food protein-induced enterocolitis syndrome.　Wada T, Toma T, Muraoka M, Matsuda Y, Yachie A.　Pediatr Allergy Immunol　25　6　617-619　2014/10
  • 　Munc13-4 deficiency with CD5 downregulation on activated CD8+ T cells.　Wada T, Yasumi T, Toma T, Hori M, Maeda S, Umeda K, Heike T, Adachi S, Usami I, Yachie A.　Pediatr Int　56　4　605-608　2014/08
  • 　Fecal eosinophil-derived neurotoxin in cow's milk-sensitive enteropathy: a case report.　Wada T, Matsuda Y, Muraoka M, Toma T, Yachie A.　Allergol Int　64　1　99-100　2015/01
  • 　Severe congenital neutropenia caused by the ELANE gene mutation in a Vietnamese boy with misdiagnosis of tuberculosis and autoimmune neutropenia: a case report.　Vu QV, Wada T, Tran TT, Ngo DN, Van Dinh T, Nguyen CH, Le HT, Yachie A, Nguyen SN.　BMC Hematol　15　2　2015/01
  • 　Basophil activation by mosquito extracts in patients with hypersensitivity to mosquito bites.　Sakakibara Y, Wada T, Muraoka M, Matsuda Y, Toma T, Yachie A.　Cancer Sci　106　8　965-971　2015/08
  • 　A Novel In-Frame Deletion in the Leucine Zipper Domain of C/EBPε Leads to Neutrophil-Specific Granule Deficiency.　Wada T, Akagi T, Muraoka M, Toma T, Kaji K, Agematsu K, Koeffler HP, Yokota T, Yachie A.　J Immunol　95　1　80-86　2015/07
  • 　The critical role of lipopolysaccharide in the upregulation of aquaporin 4 in glial cells treated with Shiga toxin.　Sugimoto N, Leu H, Inoue N, Shimizu M, Toma T, Kuroda M, Saito T, Wada T, Yachie A.　J Biomed Sci　22　78　2015/09
  • 　Late-Onset Combined Immunodeficiency with a Novel IL2RG Mutation and Probable Revertant Somatic Mosaicism.　Okuno Y, Hoshino A, Muramatsu H, Kawashima N, Wang X, Yoshida K, Wada T, Gunji M, Toma T, Kato T, Shiraishi Y, Iwata A, Hori T, Kitoh T, Chiba K, Tanaka H, Sanada M, Takahashi Y, Nonoyama S, Ito M, Miyano S, Ogawa S, Kojima S, Kanegane H.　J Clin Immunol　35　7　610-614　2015/10
  • 　An assessment of the effects of ectopic gp91phox expression in XCGD iPSC-derived neutrophils.　Lin HT, Masaki H, Yamaguchi T, Wada T, Yachie A, Nishimura K, Ohtaka M, Nakanishi M, Nakauchi H, Otsu M.　Mol Ther Methods Clin Dev　2　15046　2015/12
  • 　Disruption of vascular endothelial homeostasis in systemic juvenile idiopathic arthritis-associated macrophage activation syndrome: The dynamic roles of angiopoietin-1 and -2.　Tasaki Y, Shimizu M, Inoue N, Mizuta M, Nakagishi Y, Wada T, Yachie A.　Cytokine　80　1-6　2016/04
  • 　Tumor necrosis factor-α modifies the effects of Shiga toxin on glial cells.　Leu H, Sugimoto N, Shimizu M, Toma T, Wada T, Ohta K, Yachie A.　Int Immunopharmacol　38　139-143　2016/09
  • 　Increased CD69 Expression on Peripheral Eosinophils from Patients with Food Protein-Induced Enterocolitis Syndrome.　Wada T, Matsuda Y, Toma T, Koizumi E, Okamoto H, Yachie A.　Int Arch Allergy Immunol　170　3　201-205　2016
  • 　Hematopoietic Stem Cell Transplantation for XIAP Deficiency in Japan.　Ono S, Okano T, Hoshino A, Yanagimachi M, Hamamoto K, Nakazawa Y, Imamura T, Onuma M, Niizuma H, Sasahara Y, Tsujimoto H, Wada T, Kunisaki R, Takagi M, Imai K, Morio T, Kanegane H.　J Clin Immunol　37　1　85-91　2017/01
  • 　Agranulocytosis after infectious mononucleosis　Yokoyama, Tadafumi; Tokuhisa, Yuko; Toga, Akiko; Fujiki, Toshihiro; Sakakibara, Yasuhisa; Mase, Shintaro; Araki, Raita; Nishimura, Ryosei; Wada, Taizo; Fuseda, Tetsuya; Kato, Eiji; Yachie, Akihiro　Journal of Clinical Virology　56　3　271-273　2013/03/01　
  • 　Successful treatment of idiopathic colitis related to XIAP deficiency with allo-HSCT using reduced-intensity conditioning　Tsuma, Yusuke; Imamura, Toshihiko; Ichise, Eisuke; Sakamoto, Kenichi; Ouchi, Kazutaka; Osone, Shinya; Ishida, Hiroyuki; Wada, Taizo; Hosoi, Hajime　Pediatric Transplantation　19　1　E25-E28　2015/01/01　
  • 　Early diagnosis of Danon disease: Flow cytometric detection of lysosome-associated membrane protein-2-negative leukocytes　Hashida, Yoko; Wada, Taizo; Saito, Takekatsu; Ohta, Kunio; Kasahara, Yoshihito; Yachie, Akihiro　Journal of Cardiology　2014/06/10　
  • 　Shiga toxin-2 enhances heat-shock-induced apoptotic cell death in cultured and primary glial cells　Sugimoto, Naotoshi; Toma, Tomoko; Shimizu, Masaki; Kuroda, Mondo; Wada, Taizo; Yachie, Akihiro　Cell Biology and Toxicology　30　5　289-299　2014/01/01　
  • 　Successful treatment of systemic cytomegalovirus infection in severe combined immunodeficiency using allogeneic bone marrow transplantation followed by adoptive immunotherapy　Koura, U.; Sakaki-Nakatsubo, Hisano; Otsubo, Keisuke; Nomura, Keiko; Oshima, Koichi; Ohara, Osamu; Wada, Taizo; Yachie, Akihiro; Imai, Kohsuke; Morio, Tomohiro; Miyawaki, Toshio; Kanegane, Hirokazu　Journal of Investigational Allergology and Clinical Immunology　24　3　200-202　2014/01/01　
  • 　Down-regulation of CD5 expression on activated CD8+ T cells in familial hemophagocytic lymphohistiocytosis with perforin gene mutations　Wada, Taizo; Sakakibara, Yasuhisa; Nishimura, Ryosei; Toma, Tomoko; Ueno, Yasuhisa; Horita, Seiki; Tanaka, Taihei; Nishi, Masanori; Kato, Keisuke; Yasumi, Takahiro; Ohara, Osamu; Yachie, Akihiro　Human Immunology　74　12　1579-1585　2013/10/11　
  • 　Expansion of a liver-infiltrating cytotoxic T-lymphocyte clone in concert with the development of hepatitis-associated aplastic anaemia　Ikawa, Yasuhiro; Nishimura, Ryosei; Kuroda, Rie; Mase, Shintaro; Araki, Raita; Maeba, Hideaki; Wada, Taizo; Toma, Tomoko; Koizumi, Shoichi; Yachie, Akihiro　British Journal of Haematology　161　4　599-602　2013/05/01　
  • 　Sustained elevation of serum interleukin-18 and its association with hemophagocytic lymphohistiocytosis in XIAP deficiency　Wada, Taizo; Kanegane, Hirokazu; Ohta, Kazuhide; Katoh, Fumiyo; Imamura, Toshihiko; Nakazawa, Yozo; Miyashita, Ritsuko; Hara, Junichi; Hamamoto, Kazuko; Yang, Xi; Filipovich, Alexandra Hult; Marsh, Rebecca A.; Yachie, Akihiro　Cytokine　65　1　74-78　2014/01/01　
  • 　Clinical and immunophenotypic features of atypical complete DiGeorge syndrome　Vu, Quangvan; Wada, Taizo; Toma, Tomoko; Tajima, Hanako; Maeda, Miho; Tanaka, Risa; Oh-Ishi, Tsutomu; Yachie, Akihiro　Pediatrics International　55　1　2-6　2013/02/01　
  • 　Successful bone marrow transplantation with reduced intensity conditioning in a patient with delayed-onset adenosine deaminase deficiency　Kanegane, Hirokazu; Taneichi, Hiromichi; Nomura, Keiko; Wada, Taizo; Yachie, Akihiro; Imai, Kohsuke; Ariga, Tadashi; Santisteban, Ines; Hershfield, Michael S J E; Miyawaki, Toshio　Pediatric Transplantation　17　1　E29-E32　2013/02/01　
  • 　Rapid detection of intracellular p47phox and p67phox by flow cytometry; Useful screening tests for chronic granulomatous disease　Wada, Taizo; Muraoka, Masahiro; Toma, Tomoko; Imai, Tsuyoshi; Shigemura, Tomonari; Agematsu, Kazunaga; Haraguchi, Kohei; Moriuchi, Hiroyuki; Oh-Ishi, Tsutomu; Kitoh, Toshiyuki; Ohara, Osamu; Morio, Tomohiro; Yachie, Akihiro　Journal of Clinical Immunology　33　4　857-864　2013/05/01　
  • 　Cytokine profiles in children with primary Epstein-Barr virus infection　Wada, Taizo; Muraoka, Masahiro; Yokoyama, Tadafumi; Toma, Tomoko; Kanegane, Hirokazu; Yachie, Akihiro　Pediatric Blood and Cancer　60　7　E46-E48　2013/07/01　
  • 　Increased expression of epidermal thymic stromal lymphopoietin in inflammatory peeling skin syndrome　Wada, Taizo; Toma, Tomoko; Hamaguchi, Yasuhito; Yachie, Akihiro　Journal of Dermatology　41　5　448-449　2014/01/01　
  • 　Alu-mediated large deletion of the CDSN gene as a cause of peeling skin disease　Wada, Taizo; Matsuda, Yusuke; Muraoka, Masahiro; Toma, Tomoko; Takehara, Kazuhiko; Fujimoto, Manabu; Yachie, Akihiro　Clinical Genetics　86　4　383-386　2014/01/01　
  • 　A case of acute encephalopathy with hemophagocytic lymphohistiocytosis and clonal T-cell expansion　Wada, Taizo; Nishiura, Kashiku; Kuroda, Mondo; Asai, Erika; Vu, Quangvan; Toma, Tomoko; Niida, Yo; Yachie, Akihiro　Brain and Development　34　5　376-379　2012/05/01　
  • 　Somatic mosaicism in primary immune deficiencies.　Wada T, Candotti F.　CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY　8　6　510-514　2008/12
  • 　Delayed onset adenosine deaminase deficiency associated with acute disseminated encephalomyelitis.　Nakaoka H, Kanegane H, Taneichi H, Miya K, Yang X, Nomura K, Takezaki S, Yamada M, Ohara O, Kamae C, Imai K, Nonoyama S, Wada T, Yachie A, Hershfield MS, Ariga T, Miyawaki T.　INTERNATIONAL JOURNAL OF HEMATOLOGY　95　6　692-6　2012/06
  • 　Phenotypic analysis in a case of hydroa vacciniforme-like eruptions associated with chronic active Epstein-Barr virus disease of γδ T cells.　BRITISH JOURNAL OF DERMATOLOGY　166　1　216-8　2012/01
  • 　Multiple reversions of an IL2RG mutation restore T cell function in an X-linked severe combined immunodeficiency patient.　Kawai T,Saito M,Nishikomori R,Yasumi T,Izawa K,Murakami T,Okamoto S,Mori Y,Nakagawa N,Imai K,Nonoyama S,Wada T,Yachie A,Ohmori K,Nakahata T,Heike T　JOURNAL OF CLINICAL IMMUNOLOGY　32　4　690-7　2012/08
  • 　Characterization of Epstein-Barr virus (EBV)-infected cells in EBV-associated hemophagocytic lymphohistiocytosis in two patients with X-linked lymphoproliferative syndrome type 1 and type 2.　Yang X,Wada T,Imadome K,Nishida N,Mukai T,Fujiwara M,Kawashima H,Kato F,Fujiwara S,Yachie A,Zhao X,Miyawaki T,Kanegane H　HERPESVIRIDAE　3　1　1　2012/02
  • 　Enhanced exon 2 skipping caused by c.910G>A variant and alternative splicing of MEFV genes in two independent cases of familial Mediterranean fever.　Tone Y,Toma T,Toga A,Sakakibara Y,Wada T,Yabe M,Kusafuka H,Yachie A　MODERN RHEUMATOLOGY　22　1　45-51　2012/02
  • 　Clonal expansion of Epstein-Barr virus (EBV)-infected γδ T cells in patients with chronic active EBV disease and hydroa vacciniforme-like eruptions.　Wada T,Toga A,Sakakibara Y,Toma T,Hasegawa M,Takehara K,Shigemura T,Agematsu K,Yachie A　INTERNATIONAL JOURNAL OF HEMATOLOGY　96　4　443-9　2012/10
  • 　Clinical and immunophenotypic features of atypical complete DiGeorge syndrome.　Vu QV,Wada T,Toma T,Tajima H,Maeda M,Tanaka R,Oh-Ishi T,Yachie A　PEDIATRICS INTERNATIONAL　55　1　2-6　2013/02
  • 　Aberrant glycosylation of IgA in Wiskott-Aldrich syndrome and X-linked thrombocytopenia.　Shimizu M,Kanegane H,Wada T,Motoyoshi Y,Morio T,Candotti F,Yachie A　JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY　131　2　587-90.e1-3　2013/02
  • 　An interesting tetrad of asplenia, inflammation, hemolysis, and nephritis.　Radhakrishnan N,Yadav SP,Sachdeva A,Wada T,Yachie A　PEDIATRIC HEMATOLOGY AND ONCOLOGY　28　8　723-6　2011/11
  • 　Gene therapy for primary immune deficiencies.　Otsu M, Wada T, Candotti F　CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY　1　6　497-501　2001/12
  • 　Urinary Heme Oxygenase-1 as a Sensitive Indicator of Tubulointerstitial Inflammatory Damage in Various Renal Diseases.　Yokoyama T, Shimizu M, Ohta K, Yuno T, Okajima M, Wada T, Toma T, Koizumi S, Yachie A.　AMERICAN JOURNAL OF NEPHROLOGY　33　5　414-420　2011/04
  • 　Analysis of mutations and recombination activity in RAG-deficient patients.　Asai E, Wada T, Sakakibara Y, Toga A, Toma T, Shimizu T, Nampoothiri S, Imai K, Nonoyama S, Morio T, Muramatsu H, Kamachi Y, Ohara O, Yachie A.　CLINICAL IMMUNOLOGY　138　2　172-177　2011/02
  • 　Delayed Wound Healing in Leukocyte Adhesion Deficiency Type 1.　JOURNAL OF PEDIATRICS　158　2　342　2011/02
  • 　Human heme oxygenase-1 deficiency presenting with hemolysis, nephritis, and asplenia.　Radhakrishnan N, Yadav SP, Sachdeva A, Pruthi PK, Sawhney S, Piplani T, Wada T, Yachie A.　JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY　33　1　74-78　2011/01
  • 　Colchicine responsive chronic recurrent multifocal osteomyelitis with MEFV mutations: A variant of familial Mediterranean fever?　Shimizu M, Tone Y, Toga A, Yokoyama T, Wada T, Toma T, Yachie A.　RHEUMATOLOGY　49　11　2221-2223　2010/11
  • 　Differential resistance to antiviral drugs in an immunocompromised patient with cytomegalovirus encephalitis.　Wada T, Mase S, Shibata F, Shimizu M, Toma T, Yachie A.　JOURNAL OF CLINICAL VIROLOGY　49　3　223-224　2010/11
  • 　Distinct cytokine profiles of systemic juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis.　Shimizu M, Yokoyama T, Yamada K, Kaneda H, Wada H, Wada T, Toma T, Ohta K, Kasahara Y, Yachie A.　RHEUMATOLOGY　49　9　1645-1653　2010/09
  • 　Bicipital synovial cyst in systemic-onset juvenile idiopathic arthritis.　JOURNAL OF PEDIATRICS　157　1　168　2010/07
  • 　Clinical significance of CD5 downregulation in Epstein-Barr virus (EBV)-infected CD8+ T lymphocytes in EBV-associated hemophagocytic lymphohistiocytosis.　Toga A, Wada T, Sakakibara Y, Mase S, Araki R, Tone Y, Toma T, Kurokawa T, Yanagisawa R, Tamura K, Nishida N, Taneichi H, Kanegane H, Yachie A.　JOURNAL OF INFECTIOUS DISEASES　201　12　1923-1932　2010/06
  • 　Flow cytometric analysis of skin blister fluid induced by mosquito bites in a patient with chronic active Epstein-Barr virus infection　Wada T, Yokoyama T, Nakagawa H, Asai E, Toga A, Sakakibara Y, Shibata F, Tone Y, Shimizu M, Toma T, Yachie A.　INTERNATIONAL JOURNAL OF HEMATOLOGY　90　5　611-615　2009/12
  • 　Diffuse brain damage caused by acute twin-twin transfusion during late pregnancy.　Wada H, Nunogami K, Wada T, Niida Y, Yachie A, Koizumi S　ACTA PAEDIATRICA JAPONICA　40　4　370-373　1998/08
  • 　A syndrome of peripheral blood T-cell infection with Epstein-Barr virus (EBV) followed by EBV-positive T-cell lymphoma.　Kanegane H, Bhatia K, Gutierrez M, Kaneda H, Wada T, Yachie A, Seki H, Arai T, Kagimoto S, Okazaki M, Oh-ishi T, Moghaddam A, Wang F, Tosato G　BLOOD　91　6　2085-2091　1998/02
  • 　Complete arrest from pro- to pre-B cells in a case of B cell-negative severe combined immunodeficiency (SCID) without recombinase activating gene (RAG) mutations.　Agematsu K, Nagumo H, Hokibara S, Mori T, Wada T, Yachie A, Kanegane H, Miyawaki T, Sugita K, Karasuyama H, Komiyama A　CLINICAL AND EXPERIMENTAL IMMUNOLOGY　124　3　461-464　2001/06
  • 　Somatic mosaicism in Wiskott-Aldrich syndrome suggests in vivo reversion by a DNA slippage mechanism.　Wada T, Schurman SH, Otsu M, Garabedian EK, Ochs HD, Nelson DL, Candotti F　PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME　98　15　8697-8702　2001/07
  • 　Multiple patients with revertant mosaicism in a single Wiskott-Aldrich syndrome family.　Wada T, Schurman SH, Jagadeesh GJ, Garabedian EK, Nelson DL, Candotti F　BLOOD　104　5　1270-1272　2004/10
  • 　Oligoclonal expansion of T lymphocytes with multiple second-site mutations leads to Omenn syndrome in a patient with RAG1-deficient severe combined immunodeficiency.　Wada T, Toma T, Okamoto H, Kasahara Y, Koizumi S, Agematsu K, Kimura H, Shimada A, Hayashi Y, Kato M, Yachie A　BLOOD　106　6　2099-2101　2005/09
  • 　Analysis of T-cell repertoire diversity in Wiskott-Aldrich syndrome.　Wada T, Schurman SH, Garabedian EK, Yachie A, Candotti F　BLOOD　106　12　3895-3897　2005/12
  • 　Somatic revertant mosaicism in a patient with leukocyte adhesion deficiency type 1.　Tone Y, Wada T, Shibata F, Toma T, Hashida Y, Kasahara Y, Koizumi S, Yachie A　BLOOD　109　3　1182-1184　2007/02
  • 　Tubular injury as a cardinal pathologic feature in human heme oxygenase-1 deficiency.　Ohta K, Yachie A, Fujimoto K, Kaneda H, Wada T, Toma T, Seno A, Kasahara Y, Yokoyama H, Seki H, Koizumi S　AMERICAN JOURNAL OF KIDNEY DISEASES　35　5　863-870　2000/05
  • 　Reactive peripheral blood plasmacytosis in a patient with acute hepatitis A.　Wada T, Maeba H, Ikawa Y, Hashida Y, Okumura A, Shibata F, Tone Y, Inoue M, Koizumi S, Takatori H, Sakai Y, Kaneko S, Yachie A　INTERNATIONAL JOURNAL OF HEMATOLOGY　85　3　191-194　2007/04
  • 　Clonotypic analysis of T cell reconstitution after haematopoietic stem cell transplantation (HSCT) in patients with severe combined immunodeficiency.　Okamoto H, Arii C, Shibata F, Toma T, Wada T, Inoue M, Tone Y, Kasahara Y, Koizumi S, Kamachi Y, Ishida Y, Inagaki J, Kato M, Morio T, Yachie A　CLINICAL AND EXPERIMENTAL IMMUNOLOGY　148　3　450-460　2007/06
  • 　Immunophenotypic analysis of Epstein-Barr virus (EBV)-infected CD8+ T cells in a patient with EBV-associated hemophagocytic lymphohistiocytosis.　Wada T, Kurokawa T, Toma T, Shibata F, Tone Y, Hashida Y, Kaya H, Yoshida T, Yachie A　EUROPEAN JOURNAL OF HAEMATOLOGY　79　1　72-75　2007/07
  • 　Skin infiltration of CD56bright CD16- natural killer cells in a case of X-SCID with Omenn syndrome-like manifestations.　Shibata F, Toma T, Wada T, Inoue M, Tone Y, Ohta K, Kasahara Y, Sano F, Kimura M, Ikeno M, Koizumi S, Yachie A　EUROPEAN JOURNAL OF HAEMATOLOGY　79　1　81-85　2007/07
  • 　Detection of T lymphocytes with a second-site mutation in skin lesions of atypical X-linked severe combined immunodeficiency mimicking Omenn syndrome.　Wada T, Yasui M, Toma T, Nakayama Y, Nishida M, Shimizu M, Okajima M, Kasahara Y, Koizumi S, Inoue M, Kawa K, Yachie A　BLOOD　112　5　1872-1875　2008/09
  • 　Analysis of T cell receptor Vβ diversity in peripheral CD4+ and CD8+ T lymphocytes in patients with autoimmune thyroid diseases.　Okajima M, Wada T, Nishida M, Yokoyama T, Nakayama Y, Hashida Y, Shibata F, Tone Y, Ishizaki A, Shimizu M, Saito T, Ohta K, Toma T, Yachie A　CLINICAL AND EXPERIMENTAL IMMUNOLOGY　155　2　166-172　2009/02
  • 　Developmental changes and functional properties of human memory T cell subpopulations defined by CD60 expression.　Wada T, Seki H, Konno A, Ohta K, Nunogami K, Kaneda H, Kasahara Y, Yachie A, Koizumi S, Taniguchi N, Miyawaki T　CELLULAR IMMUNOLOGY　187　2　117-123　1998/08
  • 　Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency.　Yachie A, Niida Y, Wada T, Igarashi N, Kaneda H, Toma T, Ohta K, Kasahara Y, Koizumi S　JOURNAL OF CLINICAL INVESTIGATION　103　1　129-135　1999/01
  • 　Characterization of immune function and analysis of RAG gene mutations in Omenn syndrome and related disorders.　Wada T, Takei K, Kudo M, Shimura S, Kasahara Y, Koizumi S, Kawa-Ha K, Ishida Y, Imashuku S, Seki H, Yachie A　CLINICAL AND EXPERIMENTAL IMMUNOLOGY　119　1　148-155　2000/01
  • 　Hypokalemic periodic paralysis and mutations in the CACNL1A3 gene: case study in a Japanese family.　Wada T, Yachie A, Fujita S, Takei K, Sumita R, Ichihara T, Koizumi S　PEDIATRICS INTERNATIONAL　42　3　325-327　2000/06
  • 　Inhibitory action of sulfatide, a putative ligand for L-selectin, on B cell proliferation and Ig production.　Konno A, Nunogami K, Wada T, Yachie A, Suzuki Y, Takahashi N, Suzuki T, Miyamoto D, Kiso M, Hasegawa A, Miyawaki T　INTERNATIONAL IMMUNOLOGY　8　12　1905-1913　1996/02
  • 　Novel Fas (CD95/APO-1) mutations in infants with a lymphoproliferative disorder.　Kasahara Y, Wada T, Niida Y, Yachie A, Seki H, Ishida Y, Sakai T, Koizumi F, Koizumi S, Miyawaki T, Taniguchi N　INTERNATIONAL IMMUNOLOGY　10　2　195-202　1998/02
  • 　Differential contribution of Wiskott-Aldrich syndrome protein to selective advantage in T- and B-cell lineages.　Konno A, Wada T, Schurman SH, Garabedian EK, Kirby M, Anderson SM, Candotti F　BLOOD　103　2　676-678　2004/01
  • 　Delineation of producing ability of IgG and IgA subclasses by naive B cells in newborn infants and adult individuals.　Yachie A, Konno A, Ohta K, Wada T, Seki H, Taniguchi N, Miyawaki T　CLINICAL AND EXPERIMENTAL IMMUNOLOGY　102　1　204-209　1995/10
  • 　Second-site mutation in the Wiskott-Aldrich syndrome (WAS) protein gene causes somatic mosaicism in two WAS siblings.　Wada T, Konno A, Schurman SH, Garabedian EK, Anderson SM, Kirby M, Nelson DL, Candotti F　JOURNAL OF CLINICAL INVESTIGATION　111　9　1389-1397　2003/05
  • 　Retrovirus-mediated WASP gene transfer corrects Wiskott-Aldrich syndrome T-cell dysfunction.　Wada T, Jagadeesh GJ, Nelson DL, Candotti F　HUMAN GENE THERAPY　13　9　1039-1046　2002/06
  • 　Paradoxical enhancement of oxidative cell injury by overexpression of heme oxygenase-1 in an anchorage-dependent cell ECV304.　Maruhashi K, Kasahara Y, Ohta K, Wada T, Ohta K, Nakamura N, Toma T, Koizumi S, Yachie A　JOURNAL OF CELLULAR BIOCHEMISTRY　93　3　552-562　2004/10
  • 　Age-dependent increase of IgE-binding and FcεRI expression on circulating basophils in children.　Wada T, Toma T, Shimura S, Kudo M, Kasahara Y, Koizumi S, Ra C, Seki H, Yachie A　PEDIATRIC RESEARCH　46　5　603-607　1999/11

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○「自己炎症性疾患とその類縁疾患の全国診療体制整備、移行医療体制の構築、診療ガイドライン確立に関する研究」(2022-2025)　
○「慢性肉芽腫症腸炎に対する小児用サリドマイド製剤の実用化に関する研究」(2019-2021)　
○「原発性免疫不全症候群の診療ガイドライン改訂、診療提供体制・移行医療体制構築、データベースの確立に関する研究」(2020-2022)　
○「自己炎症性疾患とその類縁疾患の全国診療体制整備、移行医療体制の構築、診療ガイドライン確立に関する研究」(2020-2022)　
○「新規胚シグナルlaeverinの幹細胞と免疫システムに対する作用の解明と臨床応用」(2021-2024)　
○2022「血中IL-18の異常高値で特徴付けられる疾患群の病態解明と治療法開発」(2020-2022)　
○「原発性免疫不全症候群の診断基準・重症度分類および診療ガイドラインの確立に関する研究」(2019-2019)　
○「慢性活動性EBウイルス感染症と類縁疾患の疾患レジストリとバイオバンクの構築」(2019-2019)　
○「オミクス情報を駆使した全身型特発性関節炎分子病態の解明と先制医療開発」(2015-2018)　
○「好中球二次顆粒欠損症の新規Ｃ／ＥＢＰε変異と好中球分化異常に関する研究」(2015-2017)　
○「原発性免疫不全症における原因遺伝子の復帰に関する研究」(2006-2007)　
○「原発性免疫不全症における復帰変異による体細胞モザイクの意義と分子生物学的基盤」(2008-2010)　
○「EBV関連血球貪食性リンパ組織球症におけるEBV感染T細胞の解析と病態解明」(2012-2014)　

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