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Researcher Information

last modified：2024/11/22

Professor　YAMAMOTO Yasuhiko

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Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences　Department of Biochemistry and Molecular Vascular Biology
Professor
Chair, Kanazawa University Faculty of Medicine
Head, Kanazawa University School of Medicine

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Science　TEL:076-265-2181　FAX:076-234-4217

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University　Doctor　Graduate School, Division of Medicine　199603　Completed
【Academic background(Bachelor's Degree)】
Kanazawa University　School of Medicine　199203

Career

JSPS Research Associate　Dept. Biochem, Kanazawa Univ. Sch. Med.(1997/09-1999/03)
Kanazawa University　School of Medicine　Instructor(1999/04-2001/03)
Kanazawa University　Graduate School of Medical Science(2001/04-2006/06)
金沢大学　Graduate School of Medical Science(2006/07-2012/04)
Joslin Diabetes Center & Harvard Medical School　Visiting Scientist(2006/10-2009/08)
Kanazawa University　Graduate School of Medical Sciences(2012/05-2015/04)
Kanazawa University(2015/05-)
Advisor to the President(2020/04/01-2022/03/31)
Advisor to the President(2022/04/01-2024/03/31)

Year & Month of Birth

1968/03

Academic Society



JMARS
International Maillard Reaction Society (IMARS)

Anti-Aging Medicine
Japanese Society of Internal Medicine





Award



○Japan Diabetic Complication Society Young Investigator Award(2008/10/03)
○Sr. Iacocca Visiting Scientist Award(2007/05/08)
○Sumitomo Life Social Welfare Foundation(2006/09/27)
○Japan Diabetes Foundation(2004/11/26)
○Young Investigator Award, Japan Biochemical Society Hokuriku Branch(2003/05/31)
○Young Investigator Award, Japan Biochemical Society Hokuriku Branch(2003/05/31)
○Young Investigator Award, Japan Biochemical Society Hokuriku Branch(2003/05/31)

Specialities

General medical chemistry、Pathological medical chemistry

Speciality Keywords

Cellmetabolism, Diabetic vascular complications, Immunity, Neuroendocine

Research Themes

Inflammation in obesity

Cell metabolism and diseases

Molecular mechanism for development of diabetic vascular complications

Innate immunity

Books

  • 　RAGE as a functional receptor for AGE　CMC Publishers　2010/12
  • 　AGE receptors　Asakura
  • 　AGE-RAGE system in diabetic vascular complications　Nipponrinshosha Co., Ltd.　68　増刊　39-44　2010/11
  • 　Identification of mouse ortholog of endogenous secretory receptor for advanced glycation endproducts: structure, function and expression.　396　1　 109-115　2006/01
  • 　A severe diabetic nephropathy model with early development of nodule-like lesions induced by megsin overexpression in the RAGE/ iNOS transgenic mice.　55　 356-366　2006

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  • 　Development of an ELISA for esRAGE and its application to type 1 diabetic patients.　73　 158-165　2006
  • 　Deletion of RAGE causes hyperactivity and increased sensitivity to auditory stimuli in mice.　4　12　e8309　2009
  • 　Isoflavones inhibit nicotine C-oxidation catalyzed by human CYP2A6.　46　3　 337-344　2006/03
  • 　Expression profiling of endogenous secretory receptor for advanced glycation end products in human organs.　18　10　 1385-1396　2005/10

Papers

  • 　RAGE regulates oxytocin transport into the brain.　Yasuhiko Yamamoto,Haruhiro Higashida　Communications biology　3　1　70　2020/02/13
  • 　Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice　Yamamoto Y, Liang M, Munesue S, Deguchi K, Harashima A, Furuhara K, Yuhi T, Zhong J, Akther S, Goto H, Eguchi Y, Kitao Y, Hori O, Shiraishi Y, Ozaki N, Shimizu Y, Kamide T, Yoshikawa A, Hayashi Y, Nakada M, Lopatina O, Gerasimenko M, Komleva Y, Malinovskaya N, Salmina AB, Asano M, Nishimori K, Shoelson SE, Yamamoto H, Higashida H.　Commun Biol 　2　76　2019
  • 　Aquaporin 1 elicits cell motility and coordinates vascular bed formation by downregulating thrombospondin type-1 domain-containing 7A in glioblastoma.　Masahiro Oishi,Seiichi Munesue,Ai Harashima,Mitsutoshi Nakada,Yasuhiko Yamamoto,Yasuhiko Hayashi　Cancer medicine　9　11　3904　2020/06
  • 　Deletion of CD38 and supplementation of NAD+ attenuate axon degeneration in a mouse facial nerve axotomy model.　Yuji Takaso,Masao Noda,Tsuyoshi Hattori,Jureepon Roboon,Miyako Hatano,Hisashi Sugimoto,Charles Brenner,Yasuhiko Yamamoto,Hiroshi Okamoto,Haruhiro Higashida,Makoto Ito,Tomokazu Yoshizaki,Osamu Hori　Scientific reports　10　1　17795　2020/10/20
  • 　RAGE signaling is required for AMPA receptor dysfunction in the hippocampus of hyperglycemic mice.　Zeinab Momeni,Maricris Bautista,Joseph Neapetung,Rylan Urban,Yasuhiko Yamamoto,Anand Krishnan,Verónica A Campanucci　Physiology & behavior　229　113255　2021/02/01

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  • 　Advanced glycation end products-driven angiogenesis in vitro　S Yamagishi,H Yonekura,Y Yamamoto,K Katsuno,F Sato,Mita, I,H Ooka,N Satozawa,T Kawakami,M Nomura,H Yamamoto　JOURNAL OF BIOLOGICAL CHEMISTRY　272　13　8723　1997/03
  • 　Hyperglycemia induces RAGE-dependent hippocampal spatial memory impairments.　Zeinab Momeni,Joseph Neapetung,Anthony Pacholko,Tabitha Achan Bol Kiir,Yasuhiko Yamamoto,Lane K Bekar,Verónica A Campanucci Dr　Physiology & behavior　229　113287　2021/02/01
  • 　Receptor for advanced glycation end products is a promising target of diabetic nephropathy　Y Yamamoto,T Doi,Kato, I,H Shinohara,S Sakurai,H Yonekura,T Watanabe,KM Myint,A Harashima,M Takeuchi,S Takasawa,H Okamoto,N Hashimoto,M Asano,H Yamamoto　MAILLARD REACTION: CHEMISTRY AT THE INTERFACE OF NUTRITION, AGING, AND DISEASE　1043　562　2005
  • 　Clonal hematopoiesis by SLIT1-mutated hematopoietic stem cells due to a breakdown of the autocrine loop involving Slit1 in acquired aplastic anemia.　Kohei Hosokawa,Hiroki Mizumaki,Mahmoud I Elbadry,Chizuru Saito,J Luis Espinoza,An Thi Thanh Dao,Takamasa Katagiri,Ai Harashima,Akihiro Kikuchi,Akinori Kanai,Hirotaka Matsui,Toshiya Inaba,Masafumi Taniwaki,Yasuhiko Yamamoto,Shinji Nakao　Leukemia　33　11　2732　2019/11
  • 　Formation of a novel quinone epoxide metabolite of troglitazone with cytotoxic to HepG2 cells　Y Yamamoto,H Yamazaki,T Ikeda,T Watanabe,H Iwabuchi,M Nakajima,T Yokoi　DRUG METABOLISM AND DISPOSITION　30　2　155　2002/02
  • 　Roles of the receptor for advanced glycation endproducts in diabetes-induced vascular injury　H Yonekura,Y Yamamoto,S Sakurai,T Watanabe,H Yamamoto　JOURNAL OF PHARMACOLOGICAL SCIENCES　97　3　305　2005/03
  • 　Interaction of receptor for advanced glycation end products with advanced oxidation protein products induces podocyte injury　Yasuhiko Yamamoto,Hiroshi Yamamoto　KIDNEY INTERNATIONAL　82　7　733　2012/10
  • 　Controlling the receptor for advanced glycation end-products to conquer diabetic vascular complications　Yasuhiko Yamamoto,Hiroshi Yamamoto　Journal of Diabetes Investigation　3　2　107　2012/04
  • 　Endogenous Secretory Receptor for Advanced Glycation End-Products Inhibits Amyloid-beta(1-42) Uptake into Mouse Brain　Takahiro Sugihara,Seiichi Munesue,Yasuhiko Yamamoto,Shigeru Sakurai,Nasima Akhter,Yoji Kitamura,Kazuhiro Shiba,Takuo Watanabe,Hideto Yonekura,Yasuhiko Hayashi,Jun-ichiro Hamada,Hiroshi Yamamoto　JOURNAL OF ALZHEIMERS DISEASE　28　3　709　2012
  • 　Regulation of RAGE for Attenuating Progression of Diabetic Vascular Complications　Myat Thu Thu Win,Yasuhiko Yamamoto,Seiichi Munesue,Hidehito Saito,Dong Han,So Motoyoshi,Tarek Kamal,Takuro Ohara,Takuo Watanabe,Hiroshi Yamamoto　EXPERIMENTAL DIABETES RESEARCH　2012　894605　2012
  • 　Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells　Mei He,Hiroshi Kubo,Konosuke Morimoto,Naoya Fujino,Takaya Suzuki,Toru Takahasi,Mitsuhiro Yamada,Mutsuo Yamaya,Tomoyuki Maekawa,Yasuhiko Yamamoto,Hiroshi Yamamoto　EMBO REPORTS　12　4　358　2011/04
  • 　The effects of the receptor for advanced glycation end products (RAGE) on bone metabolism under physiological and diabetic conditions　Yasuhiro Hamada,Sohei Kitazawa,Riko Kitazawa,Keiji Kono,Shunsuke Goto,Hirotaka Komaba,Hideki Fujii,Yasuhiko Yamamoto,Hiroshi Yamamoto,Makoto Usami,Masafumi Fukagawa　ENDOCRINE　38　3　369　2010/12　
  • 　RAGE mediates vascular injury and inflammation after global cerebral ischemia　Tomoya Kamide,Yasuko Kitao,Toshiaki Takeichi,Akiko Okada,Hiromi Mohri,Ann Marie Schmidt,Takayuki Kawano,Seiichi Munesue,Yasuhiko Yamamoto,Hiroshi Yamamoto,Jun-ichiro Hamada,Osamu Hori　NEUROCHEMISTRY INTERNATIONAL　60　3　220　2012/02
  • 　Diabetes alters subsets of endothelial progenitor cells that reside in blood, bone marrow, and spleen　Hidehito Saito,Yasuhiko Yamamoto,Hiroshi Yamamoto　AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY　302　6　C892　2012/03
  • 　Anti-high mobility group box-1 antibody therapy for traumatic brain injury　Yu Okuma,Keyue Liu,Hidenori Wake,Jiyong Zhang,Tomoko Maruo,Isao Date,Tadashi Yoshino,Aiji Ohtsuka,Naoki Otani,Satoshi Tomura,Katsuji Shima,Yasuhiko Yamamoto,Hiroshi Yamamoto,Hideo K. Takahashi,Shuji Mori,Masahiro Nishibori　ANNALS OF NEUROLOGY　72　3　373　2012/09
  • 　Receptor for advanced glycation end products regulates adipocyte hypertrophy and insulin sensitivity in mice: Involvement of toll-like receptor 2　Masayo Monden,Hidenori Koyama,Yoshiko Otsuka,Tomoaki Morioka,Katsuhito Mori,Takuhito Shoji,Yohei Mima,Koka Motoyama,Shinya Fukumoto,Atsushi Shioi,Masanori Emoto,Yasuhiko Yamamoto,Hiroshi Yamamoto,Yoshiki Nishizawa,Masafumi Kurajoh,Tetsuya Yamamoto,Masaaki Inaba　Diabetes　62　2　478　2013/02
  • 　Induction of receptor for advanced glycation end products by insufficient leptin action triggers pancreatic beta-cell failure in type 2 diabetes　Dong Han,Yasuhiko Yamamoto,Seiichi Munesue,So Motoyoshi,Hidehito Saito,Myat Thu Thu Win,Takuo Watanabe,Koichi Tsuneyama,Hiroshi Yamamoto　GENES TO CELLS　18　4　302　2013/04
  • 　CD38 in the nucleus accumbens and oxytocin are related to paternal behavior in mice　Shirin Akther,Natalia Korshnova,Jing Zhong,Mingkun Liang,Stanislav M. Cherepanov,Olga Lopatina,Yulia K. Komleva,Alla B. Salmina,Tomoko Nishimura,Azam A. K. M. Fakhrul,Hirokazu Hirai,Ichiro Kato,Yasuhiko Yamamoto,Shin Takasawa,Hiroshi Okamoto,Haruhiro Higashida　MOLECULAR BRAIN　6　41　2013/09
  • 　Regulation of Diet-Induced Adipose Tissue and Systemic Inflammation by Salicylates and Pioglitazone　Myung-Sunny Kim,Yasuhiko Yamamoto,Kyungjin Kim,Nozomu Kamei,Takeshi Shimada,Libin Liu,Kristin Moore,Ju Rang Woo,Steven E. Shoelson,Jongsoon Lee　PLOS ONE　8　12　e82847　2013/12
  • 　The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism　K Abeyama,DM Stern,Y Ito,K Kawahara,Y Yoshimoto,M Tanaka,T Uchimura,N Ida,Y Yamazaki,S Yamada,Y Yamamoto,H Yamamoto,S Iino,N Taniguchi,Maruyama, I　JOURNAL OF CLINICAL INVESTIGATION　115　5　1267　2005/05
  • 　The effects of the receptor for advanced glycation end products (RAGE) on bone metabolism under physiological and diabetic conditions　Yasuhiro Hamada,Sohei Kitazawa,Riko Kitazawa,Keiji Kono,Shunsuke Goto,Hirotaka Komaba,Hideki Fujii,Yasuhiko Yamamoto,Hiroshi Yamamoto,Makoto Usami,Masafumi Fukagawa　Endocrine　38　3　369　2010/12
  • 　Validated Liquid Culture Monitoring System for Lifespan Extension of Caenorhabditis elegans through Genetic and Dietary Manipulations　Myat Thu Thu Win,Yasuhiko Yamamoto,Seiichi Munesue,Dong Han,Shin-ichi Harada,Hiroshi Yamamoto　AGING AND DISEASE　4　4　178　2013/08
  • 　Molecular mechanism of diabetic angiopathy　T Watanabe,H Yonekura,Y Yamamoto,S Sakurai,H Yamamoto　SEIKAGAKU　75　10　1361　2003/10
  • 　RAGE-mediated inflammation, type 2 diabetes, and diabetic vascular complication　Yasuhiko Yamamoto,Hiroshi Yamamoto　Frontiers in Endocrinology　4　105　2013
  • 　Receptor for advanced glycation end-products-mediated inflammation and diabetic vascular complications　Yasuhiko Yamamoto,Hiroshi Yamamoto　Journal of Diabetes Investigation　2　3　155　2011/06
  • 　AGE-RAGE system in the development of diabetic vascular complications　Y Yamamoto　SEIKAGAKU　75　9　1230　2003/09
  • 　Septic Shock Is Associated with Receptor for Advanced Glycation End Products Ligation of LPS　Yasuhiko Yamamoto,Ai Harashima,Hidehito Saito,Koichi Tsuneyama,Seiichi Munesue,So Motoyoshi,Dong Han,Takuo Watanabe,Masahide Asano,Shin Takasawa,Hiroshi Okamoto,Satoshi Shimura,Tadahiro Karasawa,Hideto Yonekura,Hiroshi Yamamoto　JOURNAL OF IMMUNOLOGY　186　5　3248　2011/03
  • 　Advanced glycation endproducts and RAGE have a central role in the development of diabetic vascular complications.　Yamamoto Y,Doi T,Kato I,Sakurai S,Yonekura H,Watanabe T,Myint K. M,Takasawa S,Okamoto H,Asano M,Shinohara H,Yamamoto H　Atherosclerosis Supplements　4　2　56　2003/04
  • 　Advanced glycation endproduct-induced calcium handling impairment in mouse cardiac myocytes　R Petrova,Y Yamamoto,K Muraki,H Yonekura,S Sakurai,T Watanabe,H Li,M Takeuchi,Z Makita,Kato, I,S Takasawa,H Okamoto,Y Imaizumi,H Yamamoto　JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY　34　10　1425　2002/10
  • 　CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status　Hironori Kitade,Kazuki Sawamoto,Mayumi Nagashimada,Hiroshi Inoue,Yasuhiko Yamamoto,Yoshimichi Sai,Toshinari Takamura,Hiroshi Yamamoto,Ken-ichi Miyamoto,Henry N. Ginsberg,Naofumi Mukaida,Shuichi Kaneko,Tsuguhito Ota　DIABETES　61　7　1680　2012/07
  • 　Low molecular weight heparin suppresses receptor for advanced glycation end products-mediated expression of malignant phenotype in human fibrosarcoma cells　Akihiko Takeuchi,Yasuhiko Yamamoto,Seiichi Munesue,Ai Harashima,Takuo Watanabe,Hideto Yonekura,Hiroshi Yamamoto,Hiroyuki Tsuchiya　CANCER SCIENCE　104　6　740　2013/06
  • 　[AGE-RAGE system in diabetic vascular complications].　Yamamoto Y,Yamamoto H　Nihon rinsho. Japanese journal of clinical medicine　68 Suppl 9　39　2010/11
  • 　Ocular Diseases Caused by Accumulation of Proteins with Post-translational Modifications　KAJI Yuichi　Journal of Japanese Ophthalmological Society　113　3　424　2009/03
  • 　[AGE-RAGE system in diabetic microangiopathy].　Ai Harashima,Yasuhiko Yamamoto,Hiroshi Yamamoto　Nihon rinsho. Japanese journal of clinical medicine　63 Suppl 6　62　2005/06
  • 　Plasma level of endogenous secretory RAGE is associated with components of the metabolic syndrome and atherosclerosis　H Koyama,T Shoji,H Yokoyama,K Motoyama,K Mori,S Fukumoto,M Emoto,T Shoji,H Tamei,H Matsuki,S Sakurai,Y Yamamoto,H Yonekura,T Watanabe,H Yamamoto,Y Nishizawa　ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY　25　12　2587　2005/12
  • 　Role of cell-cell interactions in high mobility group box 1 cytokine activity in human peripheral blood mononuclear cells and mouse splenocytes　Hideo Kohka Takahashi,Hiroshi Sadamori,Keyue Liu,Hidenori Wake,Shuji Mori,Tadashi Yoshino,Yasuhiko Yamamoto,Hiroshi Yamamoto,Masahiro Nishibori　European Journal of Pharmacology　701　1-3　194　2013/02/15
  • 　Emphysema Requires the Receptor for Advanced Glycation End-Products Triggering on Structural Cells　Koichi Waseda,Nobuaki Miyahara,Akihiko Taniguchi,Etsuko Kurimoto,Genyo Ikeda,Hikari Koga,Utako Fujii,Yasuhiko Yamamoto,Erwin W. Gelfand,Hiroshi Yamamoto,Mitsune Tanimoto,Arihiko Kanehiro　AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY　52　4　482　2015/04
  • 　[Therapeutic strategies for RAGE-mediated diseases].　Yamamoto Y,Yamamoto H　Nihon yakurigaku zasshi. Folia pharmacologica Japonica　143　1　10　2014/01　
  • 　Longistatin in tick saliva blocks advanced glycation end-product receptor activation　Anisuzzaman,Takeshi Hatta,Takeharu Miyoshi,Makoto Matsubayashi,M. Khyrul Islam,M. Abdul Alim,M. Abu Anas,M. Mehedi Hasan,Yasunobu Matsumoto,Yasuhiko Yamamoto,Hiroshi Yamamoto,Kozo Fujisaki,Naotoshi Tsuji　JOURNAL OF CLINICAL INVESTIGATION　124　10　4429　2014/10
  • 　Enzymatic and non-enzymatic post-translational modifications linking diabetes and heart disease　Yasuhiko Yamamoto,Hiroshi Yamamoto　JOURNAL OF DIABETES INVESTIGATION　6　1　16　2015/01
  • 　Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity　Byung-Cheol Lee,Myung-Sunny Kim,Munkyong Pae,Yasuhiko Yamamoto,Delphine Eberle,Takeshi Shimada,Nozomu Kamei,Hee-Sook Park,Souphatta Sasorith,Ju Rang Woo,Jia You,William Mosher,Hugh J. M. Brady,Steven E. Shoelson,Jongsoon Lee　CELL METABOLISM　23　4　685　2016/04
  • 　Contrasting roles for the receptor for advanced glycation end-products on structural cells in allergic airway inflammation vs. airway hyperresponsiveness　Akihiko Taniguchi,Nobuaki Miyahara,Koichi Waseda,Etsuko Kurimoto,Utako Fujii,Yasushi Tanimoto,Mikio Kataoka,Yasuhiko Yamamoto,Erwin W. Gelfand,Hiroshi Yamamoto,Mitsune Tanimoto,Arihiko Kanehiro　AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY　309　8　L789　2015/10
  • 　Growth Arrest and DNA Damage-Inducible 34 Regulates Liver Regeneration in Hepatic Steatosis in Mice　Yuka Inaba,Tomoko Furutani,Kumi Kimura,Hitoshi Watanabe,Sanae Haga,Yoshiaki Kido,Michihiro Matsumoto,Yasuhiko Yamamoto,Kenichi Harada,Shuichi Kaneko,Seiichi Oyadomari,Michitaka Ozaki,Masato Kasuga,Hiroshi Inoue　HEPATOLOGY　61　4　1343　2015/04
  • 　RAGE mediates the inactivation of nAChRs in sympathetic neurons under high glucose conditions　Andrew R. Chandna,Manoj Nair,Christine Chang,Paul R. Pennington,Yasuhiko Yamamoto,Darrell D. Mousseau,Veronica A. Campanucci　EUROPEAN JOURNAL OF NEUROSCIENCE　41　3　341　2015/02
  • 　RAGE Expression in Tumor-Associated Macrophages Promotes Angiogenesis in Glioma　Xuebo Chen,Leying Zhang,Ian Y. Zhang,Junling Liang,Huaqing Wang,Mao Ouyang,Shihua Wu,Anna Carolina Carvalho da Fonseca,Lihong Weng,Yasuhiko Yamamoto,Hiroshi Yamamoto,Rama Natarajan,Behnam Badie　CANCER RESEARCH　74　24　7285　2014/12
  • 　Receptor for advanced glycation end products and its ligand high-mobility group box-1 mediate allergic airway sensitization and airway inflammation　Md Ashik Ullah,Zhixuan Loh,Wan Jun Gan,Vivian Zhang,Huan Yang,Jian Hua Li,Yasuhiko Yamamoto,Ann Marie Schmidt,Carol L. Armour,J. Margaret Hughes,Simon Phipps,Maria B. Sukkar　JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY　134　2　440　2014/08
  • 　Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis　Kenichi Harada,Yuko Kakuda,Yasunori Sato,Hiroko Ikeda,Shinji Shimoda,Yasuhiko Yamamoto,Hiroshi Inoue,Hajime Ohta,Satomi Kasashima,Atsuhiro Kawashima,Yasuni Nakanuma　JOURNAL OF CLINICAL PATHOLOGY　67　5　396　2014/05
  • 　Sivelestat Sodium Hydrate Inhibits Neutrophil Migration to the Vessel Wall and Suppresses Hepatic Ischemia-Reperfusion Injury　Seisho Sakai,Hidehiro Tajima,Tomoharu Miyashita,Shin-ichi Nakanuma,Isamu Makino,Hironori Hayashi,Hisatoshi Nakagawara,Hirohisa Kitagawa,Sachio Fushida,Takashi Fujimura,Hidehito Saito,Seiichi Munesue,Yasuhiko Yamamoto,Tetsuo Ohta　DIGESTIVE DISEASES AND SCIENCES　59　4　787　2014/04
  • 　Low-molecular weight fractions of Japanese soy sauce act as a RAGE antagonist via inhibition of RAGE trafficking to lipid rafts　Seiichi Munesue,Yasuhiko Yamamoto,Ryouta Urushihara,Kouhei Inomata,Hidehito Saito,So Motoyoshi,Takuo Watanabe,Hideto Yonekura,Hiroshi Yamamoto　FOOD & FUNCTION　4　12　1835　2013/12
  • 　Clinical relevance of peroxisome proliferator-activated receptor-gamma expression in myxoid liposarcoma　Akihiko Takeuchi,Norio Yamamoto,Toshiharu Shirai,Katsuhiro Hayashi,Shinji Miwa,Seiichi Munesue,Yasuhiko Yamamoto,Hiroyuki Tsuchiya　BMC CANCER　16　442　2016/07
  • 　Receptor for advanced glycation end products expressed on alveolar epithelial cells is the main target for hyperoxia-induced lung injury　Chiharu Ota,Kota Ishizawa,Mitsuhiro Yamada,Yukiko Tando,Mei He,Toru Takahashi,Mutsuo Yamaya,Yasuhiko Yamamoto,Hiroshi Yamamoto,Shigeo Kure,Hiroshi Kubo　Respiratory Investigation　54　2　98　2016/03/01
  • 　Glycyrrhizin inhibits traumatic brain injury by reducing HMGB1-RAGE interaction　Yu Okuma,Keyue Liu,Hidenori Wake,Rui Liu,Yoshito Nishimura,Zhong Hui,Kiyoshi Teshigawara,Jun Haruma,Yasuhiko Yamamoto,Hiroshi Yamamoto,Isao Date,Hideo K. Takahashi,Shuji Mori,Masahiro Nishibori　NEUROPHARMACOLOGY　85　18　2014/10
  • 　Thrombomodulin Modulates Dendritic Cells via Both Antagonism of High Mobility Group Protein B1 and an Independent Mechanism　Masaaki Toda,Corina N. D'Alessandro-Gabazza,Takehiro Takagi,Ayshwarya-Lakshmi Chelakkot-Govindalayathila,Osamu Taguchi,Ziaurahman Roeen,Seiichi Munesue,Yasuhiko Yamamoto,Hiroshi Yamamoto,Esteban C. Gabazza,John Morser　ALLERGOLOGY INTERNATIONAL　63　1　57　2014/03
  • 　cAMP ameliorates inflammation by modulation of macrophage receptor for advanced glycation end-products　So Motoyoshi,Yasuhiko Yamamoto,Seiichi Munesue,Hirobumi Igawa,Ai Harashima,Hidehito Saito,Dong Han,Takuo Watanabe,Hiroshi Sato,Hiroshi Yamamoto　BIOCHEMICAL JOURNAL　463　1　75　2014/10
  • 　Receptor for advanced glycation endproducts modulates leukotriene B-4 receptor 1 signaling　Takako Ichiki,Tomoaki Koga,Toshiaki Okuno,Kazuko Saeki,Yasuhiko Yamamoto,Masakiyo Sakaguchi,Takehiko Yokomizo　FASEB JOURNAL　30　2016/04
  • 　Receptor for advanced glycation endproducts modulates leukotriene B-4 receptor 1 signaling　Takako Ichiki,Tomoaki Koga,Toshiaki Okuno,Kazuko Saeki,Yasuhiko Yamamoto,Masakiyo Sakaguchi,Takehiko Yokomizo　FASEB JOURNAL　30　2016/04
  • 　Longistatin in tick saliva blocks advanced glycation end-product receptor activation　Anisuzzaman,Takeshi Hatta,Takeharu Miyoshi,Makoto Matsubayashi,M. Khyrul Islam,M. Abdul Alim,M. Abu Anas,M. Mehedi Hasan,Yasunobu Matsumoto,Yasuhiko Yamamoto,Hiroshi Yamamoto,Kozo Fujisaki,Naotoshi Tsuji　JOURNAL OF CLINICAL INVESTIGATION　124　10　4429　2014/10
  • 　中枢神経・認知症 内在性分泌型RAGEは脳虚血から神経細胞を保護する　清水 有,山本 靖彦,原島 愛,棟居 聖一,大石 正博,林 康彦,中田 光俊,北尾 康子,堀 修,山本 博　糖尿病合併症　29　Suppl.1　197　2015/11
  • 　Epidermal expression of receptor for advanced glycation end products (RAGE) is related to inflammation and apoptosis in human skin　Maeko Iwamura,Yasuhiko Yamamoto,Yoshiaki Kitayama,Kazuhiko Higuchi,Tsutomu Fujimura,Tadashi Hase,Hiroshi Yamamoto　EXPERIMENTAL DERMATOLOGY　25　3　235　2016/03
  • 　Preventive Effect of Salicylate and Pyridoxamine on Diabetic Nephropathy　Tarek Kamal Abouzed,Seiichi Munesue,Ai Harashima,Yusuke Masuo,Yukio Kato,Khaled Khailo,Hiroshi Yamamoto,Yasuhiko Yamamoto　JOURNAL OF DIABETES RESEARCH　2016　1786789　2016
  • 　Modulation of leukotriene B4 receptor 1 signaling by receptor for advanced glycation end products (RAGE)　Takako Ichiki,Tomoaki Koga,Toshiaki Okuno,Kazuko Saeki,Yasuhiko Yamamoto,Hiroshi Yamamoto,Masakiyo Sakaguchi,Takehiko Yokomizo　FASEB JOURNAL　30　5　1811　2016/05
  • 　Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus during Social or Psychological Stress in Mice.　Jing Zhong,Sarwat Amina,Mingkun Liang,Shirin Akther,Teruko Yuhi,Tomoko Nishimura,Chiharu Tsuji,Takahiro Tsuji,Hong-Xiang Liu,Minako Hashii,Kazumi Furuhara,Shigeru Yokoyama,Yasuhiko Yamamoto,Hiroshi Okamoto,Yong Juan Zhao,Hon Cheung Lee,Makoto Tominaga,Olga Lopatina,Haruhiro Higashida　Frontiers in neuroscience　10　304　2016
  • 　Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus during Social or Psychological Stress in Mice　Jing Zhong,Sarwat Amina,Mingkun Liang,Shirin Akther,Teruko Yuhi,Tomoko Nishimura,Chiharu Tsuji,Takahiro Tsuji,Hong-Xiang Liu,Minako Hashii,Kazumi Furuhara,Shigeru Yokoyama,Yasuhiko Yamamoto,Hiroshi Okamoto,Yong Juan Zhao,Hon Cheung Lee,Makoto Tominaga,Olga Lopatina,Haruhiro Higashida　FRONTIERS IN NEUROSCIENCE　10　2016/07
  • 　[AGE-RAGE system].　Ai Harashima,Seiichi Munesue,Yasuhiko Yamamoto　Nihon rinsho. Japanese journal of clinical medicine　74 Suppl 2　49　2016/04
  • 　CD38 in the Nucleus Accumbens is Critical in Paternal Behavior in Mice　Akther, Shirin,Zhong, Jing,Liang, Mingkun,Cherepanov,Stanislav M,Lopatina, Olga,Salmina, Alla B,Tsuji, Chiharu,Tsuji, Takahiro,Yamamoto, Yasuhiko,Yokoyama, Shegeru,Higashida, Haruhiro　6　4　81　2018/11
  • 　Nitration and Glycation Turn Mature NGF into a Toxic Factor for Motor Neurons: A Role for p75NTR and RAGE Signaling in ALS　Mi Jin Kim,Marcelo R. Vargas,Benjamin A. Harlan,Kelby M. Killoy,Lauren E. Ball,Susana Comte-Walters,Monika Gooz,Yasuhiko Yamamoto,Joseph S. Beckman,Luis Barbeito,Mariana Pehar　Antioxidants and Redox Signaling　28　18　1587　2018/06/20
  • 　Soluble Thrombomodulin Attenuates Endothelial Cell Damage in Hepatic Sinusoidal Obstruction Syndrome.　Takada S,Miyashita T,Yamamoto Y,Kanou S,Munesue S,Ohbatake Y,Nakanuma S,Okamoto K,Sakai S,Kinoshita J,Makino I,Nakamura K,Tajima H,Takamura H,Ninomiya I,Fushida S,Ohta T　In vivo (Athens, Greece)　32　6　1409　2018/11
  • 　Citrullinated Histone H3: Early Biomarker of Neutrophil Extracellular Traps in Septic Liver Damage.　Kozo Nomura,Tomoharu Miyashita,Yasuhiko Yamamoto,Seiichi Munesue,Ai Harashima,Hideo Takayama,Sachio Fushida,Tetsuo Ohta　The Journal of surgical research　234　132　2019/02
  • 　JNK and ATF4 as two important platforms for tumor necrosis factor-α-stimulated shedding of receptor for advanced glycation end products.　Miyoshi A,Koyama S,Sasagawa-Monden M,Kadoya M,Konishi K,Shoji T,Inaba M,Yamamoto Y,Koyama H　FASEB journal : official publication of the Federation of American Societies for Experimental Biology　33　3　3575　2019/03
  • 　Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice.　Yasuhiko Yamamoto,Mingkun Liang,Seiichi Munesue,Kisaburo Deguchi,Ai Harashima,Kazumi Furuhara,Teruko Yuhi,Jing Zhong,Shirin Akther,Hisanori Goto,Yuya Eguchi,Yasuko Kitao,Osamu Hori,Yoshitake Shiraishi,Noriyuki Ozaki,Yu Shimizu,Tomoya Kamide,Akifumi Yoshikawa,Yasuhiko Hayashi,Mitsutoshi Nakada,Olga Lopatina,Maria Gerasimenko,Yulia Komleva,Natalia Malinovskaya,Alla B Salmina,Masahide Asano,Katsuhiko Nishimori,Steven E Shoelson,Hiroshi Yamamoto,Haruhiro Higashida　Communications biology　2　76　2019
  • 　Development of a Highly Potent Analogue and a Long-Acting Analogue of Oxytocin for the Treatment of Social Impairment-Like Behaviors.　Wataru Ichinose,Stanislav M Cherepanov,Anna A Shabalova,Shigeru Yokoyama,Teruko Yuhi,Hiroaki Yamaguchi,Ayu Watanabe,Yasuhiko Yamamoto,Hiroshi Okamoto,Shinichi Horike,Junpei Terakawa,Takiko Daikoku,Mizuki Watanabe,Nariyasu Mano,Haruhiro Higashida,Satoshi Shuto　Journal of medicinal chemistry　62　7　3297　2019/04/11
  • 　Upregulation of Mobility in Pancreatic Cancer Cells by Secreted S100A11 Through Activation of Surrounding Fibroblasts.　Yosuke Mitsui,Nahoko Tomonobu,Masami Watanabe,Rie Kinoshita,I Wayan Sumardika,Chen Youyi,Hitoshi Murata,Ken-Ichi Yamamoto,Takuya Sadahira,Acosta Gonzalez Herik Rodrigo,Hitoshi Takamatsu,Kota Araki,Akira Yamauchi,Masahiro Yamamura,Hideyo Fujiwara,Yusuke Inoue,Junichiro Futami,Ken Saito,Hidekazu Iioka,Eisaku Kondo,Masahiro Nishibori,Shinichi Toyooka,Yasuhiko Yamamoto,Yasutomo Nasu,Masakiyo Sakaguchi　Oncology research　27　8　945　2019/08/08
  • 　The regulation of soluble receptor for AGEs contributes to carbonyl stress in schizophrenia.　Mitsuhiro Miyashita,Takuo Watanabe,Tomoe Ichikawa,Kazuya Toriumi,Yasue Horiuchi,Akiko Kobori,Itaru Kushima,Ryota Hashimoto,Motoyuki Fukumoto,Shinsuke Koike,Hiroshi Ujike,Tadao Arinami,Yoshitaka Tatebayashi,Kiyoto Kasai,Masatoshi Takeda,Norio Ozaki,Yuji Okazaki,Takeo Yoshikawa,Naoji Amano,Shinsuke Washizuka,Hiroshi Yamamoto,Toshio Miyata,Masanari Itokawa,Yasuhiko Yamamoto,Makoto Arai　Biochemical and biophysical research communications　479　3　447　2016/10/21
  • 　Contribution of methylglyoxal to delayed healing of bone injury in diabetes　Takao Aikawa,Hidenori Matsubara,Shuhei Ugaji,Junichi Shirakawa,Ryoji Nagai,Seiichi Munesue,Ai Harashima,Yasuhiko Yamamoto,Hiroyuki Tsuchiya　MOLECULAR MEDICINE REPORTS　16　1　403　2017/07
  • 　From insulin synthesis to secretion: Alternative splicing of type 2 ryanodine receptor gene is essential for insulin secretion in pancreatic beta cells　Hiroshi Okamoto,Shin Takasawa,Yasuhiko Yamamoto　INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY　91　Pt B　176　2017/10
  • 　In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system.　Ali Hafez Ali Mohammed El-Far,Seiichi Munesue,Ai Harashima,Akira Sato,Mika Shindo,Shingo Nakajima,Mana Inada,Mariko Tanaka,Akihiko Takeuchi,Hiroyuki Tsuchiya,Hiroshi Yamamoto,Hazem M E Shaheen,Yasser S El-Sayed,Shuhei Kawano,Sei-Ichi Tanuma,Yasuhiko Yamamoto　Oncology letters　15　4　4627　2018/04
  • 　Intestinal transepithelial permeability of oxytocin into the blood is dependent on the receptor for advanced glycation end products in mice　Haruhiro Higashida,Kazumi Furuhara,Agnes-Mikiko Yamauchi,Kisaburo Deguchi,Ai Harashima,Seiichi Munesue,Olga Lopatina,Maria Gerasimenko,Alla B. Salmina,Jia-Sheng Zhang,Hikari Kodama,Hironori Kuroda,Chiharu Tsuji,Satoshi Suto,Hiroshi Yamamoto,Yasuhiko Yamamoto　SCIENTIFIC REPORTS　7　1　7883　2017/08
  • 　Effects of Three Lipidated Oxytocin Analogs on Behavioral Deficits in CD38 Knockout Mice.　Stanislav M Cherepanov,Shirin Akther,Tomoko Nishimura,Anna A Shabalova,Akira Mizuno,Wataru Ichinose,Satoshi Shuto,Yasuhiko Yamamoto,Shigeru Yokoyama,Haruhiro Higashida　Brain sciences　7　10　2017/10/16
  • 　CD38 is Required for Dendritic Organization in Visual Cortex and Hippocampus　Thom P. Nelissen,Rosemary A. Bamford,Shiro Tochitani,Kamuran Akkus,Aurimas Kudzinskas,Kenichiro Yokoi,Hiroshi Okamoto,Yasuhiko Yamamoto,J. Peter H. Burbach,Hideo Matsuzaki,Asami Oguro-Ando　Neuroscience　372　114　2018/02/21
  • 　Anti-tumor effects of a nonsteroidal anti-inflammatory drug zaltoprofen on chondrosarcoma via activating peroxisome proliferator-activated receptor gamma and suppressing matrix metalloproteinase-2 expression.　Takashi Higuchi,Akihiko Takeuchi,Seiichi Munesue,Norio Yamamoto,Katsuhiro Hayashi,Hiroaki Kimura,Shinji Miwa,Hiroyuki Inatani,Shingo Shimozaki,Takashi Kato,Yu Aoki,Kensaku Abe,Yuta Taniguchi,Hisaki Aiba,Hideki Murakami,Ai Harashima,Yasuhiko Yamamoto,Hiroyuki Tsuchiya　Cancer medicine　7　5　1944　2018/05
  • 　TRPM2, a New Player, in Cyclic ADP-Ribose/CD38-Dependent Oxytocin Release in the Hypothalamus　Tsuji, Takahiro,Liang, Mingkun,Lopatina, Olga,Yuhi, Teruko,Tsuji, Chiharu,Zhong, Jing,Akther, Shirin,Nishimura, Tomoko,Amina, Sarwat,Liu, Hong-Xiang,Hashii, Minako,Furuhara, Kazumi,Yamamoto, Yasuhiko,Yokoyama, Shigeru,Higashida, Haruhiro　6　5　71　2018/11
  • 　Structure-specific effects of lipidated oxytocin analogs on intracellular calcium levels, parental behavior, and oxytocin concentrations in the plasma and cerebrospinal fluid in mice.　Stanislav M Cherepanov,Shigeru Yokoyama,Akira Mizuno,Wataru Ichinose,Olga Lopatina,Anna A Shabalova,Alla B Salmina,Yasuhiko Yamamoto,Hiroshi Okamoto,Satoshi Shuto,Haruhiro Higashida　Pharmacology research & perspectives　5　1　e00290　2017/02
  • 　Monitoring of Heat Shock Response and Phenotypic Changes in Hepatocellular Carcinoma After Heat Treatment.　Ryosuke Zaimoku,Tomoharu Miyashita,Hidehiro Tajima,Hiroyuki Takamura,A I Harashima,Seiichi Munesue,Yasuhiko Yamamoto,Itasu Ninomiya,Sachio Fushida,Kenichi Harada　Anticancer research　39　10　5393　2019/10
  • 　Atf6 alpha deficiency suppresses microglial activation and ameliorates pathology of experimental autoimmune encephalomyelitis　Hieu Minh Ta,Thuong Manh Le,Hiroshi Ishii,Mika Takarada-Iemata,Tsuyoshi Hattori,Koji Hashida,Yasuhiko Yamamoto,Kazutoshi Mori,Ryosuke Takahashi,Yasuko Kitao,Osamu Hori　JOURNAL OF NEUROCHEMISTRY　139　6　1124　2016/12
  • 　Extracellular S100A11 Plays a Critical Role in Spread of the Fibroblast Population in Pancreatic Cancers.　Hitoshi Takamatsu,Ken-Ichi Yamamoto,Nahoko Tomonobu,Hitoshi Murata,Yusuke Inoue,Akira Yamauchi,I Wayan Sumardika,Youyi Chen,Rie Kinoshita,Masahiro Yamamura,Hideyo Fujiwara,Yosuke Mitsui,Kota Araki,Junichiro Futami,Ken Saito,Hidekazu Iioka,I Made Winarsa Ruma,Endy Widya Putranto,Masahiro Nishibori,Eisaku Kondo,Yasuhiko Yamamoto,Shinichi Toyooka,Masakiyo Sakaguchi　Oncology research　27　6　713　2019/06/21
  • 　Deletion of CD38 Suppresses Glial Activation and Neuroinflammation in a Mouse Model of Demyelination.　Jureepon Roboon,Tsuyoshi Hattori,Hiroshi Ishii,Mika Takarada-Iemata,Thuong Manh Le,Yoshitake Shiraishi,Noriyuki Ozaki,Yasuhiko Yamamoto,Akira Sugawara,Hiroshi Okamoto,Haruhiro Higashida,Yasuko Kitao,Osamu Hori　Frontiers in cellular neuroscience　13　258　2019
  • 　RAGE-dependent potentiation of TRPV1 currents in sensory neurons exposed to high glucose　Doris Lam,Zeinab Momeni,Michael Theaker,Santosh Jagadeeshan,Yasuhiko Yamamoto,Juan P. Ianowski,Verónica A. Campanucci　PLoS ONE　13　2　e0193312　2018/02/01
  • 　CD38 positively regulates postnatal development of astrocytes cell-autonomously and oligodendrocytes non-cell-autonomously　Tsuyoshi Hattori,Minoru Kaji,Hiroshi Ishii,Roboon Jureepon,Mika Takarada-Iemata,Hieu Minh Ta,Thuong Manh Le,Ayumu Konno,Hirokazu Hirai,Yoshitake Shiraishi,Noriyuki Ozaki,Yasuhiko Yamamoto,Hiroshi Okamoto,Shigeru Yokoyama,Haruhiro Higashida,Yasuko Kitao,Osamu Hori　GLIA　65　6　974　2017/06
  • 　Low-dose paclitaxel suppresses the induction of M2 macrophages in gastric cancer　Takahisa Yamaguchi,Sachio Fushida,Yasuhiko Yamamoto,Tomoya Tsukada,Jun Kinoshita,Katsunobu Oyama,Tomoharu Miyashita,Hidehiro Tajima,Itasu Ninomiya,Seiichi Munesue,Ai Harashima,Shinichi Harada,Hiroshi Yamamoto,Tetsuo Ohta　ONCOLOGY REPORTS　37　6　3341　2017/06
  • 　Tumor-associated macrophages of the M2 phenotype contribute to progression in gastric cancer with peritoneal dissemination　Takahisa Yamaguchi,Sachio Fushida,Yasuhiko Yamamoto,Tomoya Tsukada,Jun Kinoshita,Katsunobu Oyama,Tomoharu Miyashita,Hidehiro Tajima,Itasu Ninomiya,Seiichi Munesue,Ai Harashima,Shinichi Harada,Hiroshi Yamamoto,Tetsuo Ohta　GASTRIC CANCER　19　4　1052　2016/10
  • 　Effects of RAGE inhibition on the progression of the disease in hSOD1G93A ALS mice.　Liping Liu,Kelby M Killoy,Marcelo R Vargas,Yasuhiko Yamamoto,Mariana Pehar　Pharmacology research & perspectives　8　4　e00636　2020/08
  • 　CD38, CD157, and RAGE as Molecular Determinants for Social Behavior.　Haruhiro Higashida,Minako Hashii,Yukie Tanaka,Shigeru Matsukawa,Yoshihiro Higuchi,Ryosuke Gabata,Makoto Tsubomoto,Noriko Seishima,Mitsuyo Teramachi,Taiki Kamijima,Tsuyoshi Hattori,Osamu Hori,Chiharu Tsuji,Stanislav M Cherepanov,Anna A Shabalova,Maria Gerasimenko,Kana Minami,Shigeru Yokoyama,Sei-Ichi Munesue,Ai Harashima,Yasuhiko Yamamoto,Alla B Salmina,Olga Lopatina　Cells　9　1　2019/12/25
  • 　Oxytocin and CD38 in the paraventricular nucleus play a critical role in paternal aggression in mice.　Anna A Shabalova,Mingkun Liang,Jing Zhong,Zhiqi Huang,Chiharu Tsuji,Natalia A Shnayder,Olga Lopatina,Alla B Salmina,Hiroshi Okamoto,Yasuhiko Yamamoto,Zeng-Guo Zhong,Shigeru Yokoyama,Haruhiro Higashida　Hormones and behavior　120　104695　2020/04
  • 　Intake of ω-6 Polyunsaturated Fatty Acid-Rich Vegetable Oils and Risk of Lifestyle Diseases.　Tetsumori Yamashima,Tsuguhito Ota,Eishiro Mizukoshi,Hiroyuki Nakamura,Yasuhiko Yamamoto,Mitsuru Kikuchi,Tatsuya Yamashita,Shuichi Kaneko　Advances in nutrition (Bethesda, Md.)　11　6　1489　2020/11/16
  • 　Glycation reaction and the role of the receptor for advanced glycation end-products in immunity and social behavior.　Nontaphat Leerach,Ai Harashima,Seiichi Munesue,Kumi Kimura,Yu Oshima,Hisanori Goto,Hiroshi Yamamoto,Haruhiro Higashida,Yasuhiko Yamamoto　Glycoconjugate journal　38　3　303　2020/10/27
  • 　Inhibitory Effects of Beraprost Sodium in Murine Hepatic Sinusoidal Obstruction Syndrome.　Makoto Nakura,Tomoharu Miyashita,Yasuhiko Yamamoto,Satoshi Takada,Shunsuke Kanou,Hidehiro Tajima,Hiroyuki Takamura,Tetsuo Ohta　Anticancer research　40　9　5171　2020/09
  • 　Neuroprotective Effects of Endogenous Secretory Receptor for Advanced Glycation End-products in Brain Ischemia.　Yu Shimizu,Ai Harashima,Seiichi Munesue,Masahiro Oishi,Tsuyoshi Hattori,Osamu Hori,Yasuko Kitao,Hiroshi Yamamoto,Nontaphat Leerach,Mitsutoshi Nakada,Yasuhiko Yamamoto,Yasuhiko Hayashi　Aging and disease　11　3　547　2020/05
  • 　Distinct physical condition and social behavior phenotypes of CD157 and CD38 knockout mice during aging.　Maria Gerasimenko,Olga Lopatina,Anna A Shabalova,Stanislav M Cherepanov,Alla B Salmina,Shigeru Yokoyama,Hisanori Goto,Hiroshi Okamoto,Yasuhiko Yamamoto,Katsuhiko Ishihara,Haruhiro Higashida　PloS one　15　12　e0244022　2020
  • 　Development of a highly potent analogue and a long-acting analogue of oxytocin for the treatment of social impairment-like behaviors.　Ichinose W, Cherepanov SM, Shabalova AA, Yokoyama S, Yuhi T, Yamaguchi H, Watanabe A, Yamamoto Y, Okamoto H, Horike S, Terakawa J, Daikoku T, Watanabe M, Mano N, Higashida H, Shuto S.　J Med Chem　2019
  • 　Extracellular S100A11 plays a critical role in spread of the fibroblast population in pancreatic cancers　Takamatsu H, Yamamoto K, Tomonobu N, Murata H, Inoue Y, Yamauchi A, Sumardika W, Youyi C, Kinoshita R, Yamamura M, Fujiwara H, Mitsui Y, Araki K, Futami J, Saito K, Iioka H, Ruma MW, Putranto EW, Nishibori M, Kondo E, Yamamoto Y, Toyooka S, Sakaguchi M.　Oncol Res　2019
  • 　JNK and ATF4 as two important platforms for tumor necrosis factor-α-stimulated shedding of receptor for advanced glycation endproducts　Miyoshi A, Koyama S, Sasagawa-Monden M, Kadoya M, Konishi K, Shoji T, Inaba M, Yamamoto Y, Koyama H. 　FASEB J　33　3　3575-3589　2019
  • 　Tuning inflammation: inducing ectodomain shedding of receptor for advanced glycation end-products (RAGE) and formation of soluble RAGE　Kawano S, Yamamoto Y. 　IMARS Highlight　14　1　18-19　2019
  • 　Soluble thrombomodulin attenuates endothelial cell damage in hepatic sinusoidal obstruction syndrome　Takada S, Miyashita T, Yamamoto Y, Kanou S, Munesue S, Ohbatake Y, Nakanuma S, Okamoto K, Sakai S, Knoshita J, Makino I, Nakamura K, Tajima H, Takamura H, Ninomiya I, Fushida S, Ohta T.　In Vivo　32　6　1409-1417　2018
  • 　In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system　El-Far A, Munesue S, Harashima A, Sato A, Shindo M, Nakajima S, Inada M, Tanaka M, Takeuchi A, Tsuchiya H, Yamamoto H, Shaheen HME, El-Sayed YS, Kawano S, Tanuma S, Yamamoto Y.　Oncology Lett　25　4　4627-4634　2018
  • 　Nitration and glycation turn mature NGF into a toxic factor for motor neurons: a role for p75NTR and RAGE signaling in ALS　Kim MJ, Vargas MR, Harlan BA, Killoy KM, Ball L, Comte-Walters S, Gooz M, Yamamoto Y, Beckman JS, Barbeito L, Pehar M.　Antioxid Redox Signal　28　18　1587-1602　2018
  • 　Citrullinated histone H3: early biomarker of neutrophil extracellular traps in septic liver damage　Nomura K, Miyashita T, Yamamoto Y, Munesue S, Harashima A, Takayama H, Fushida S, Ohta T.　J Surg Res　234　132-138　2018
  • 　TRPM2, a new player, in cyclic ADP-ribose/CD38-dependent oxytocin release in the hypothalamus　Tsuji T, Liang M, Lopatina O, Yuhi T, Tsuji C, Zhong J, Akther S, Zhong J, Nishimura T, Amina S, Liu HX, Hashii M, Furuhara K, Yamamoto Y, Yokoyama S, Higashida H.　Messenger　6　71-75　2018
  • 　CD38 in the nucleus accumbens is critical in paternal behavior in mice　Akther S, Zhong J, Liang M, Cherepanov SM, Lopatina O, Salmina AB, Tsuji C, Tsuji T, Yamamoto Y, Yokoyama S, Higashida H.　Messenger　6　81-84　2018
  • 　CD38 is Required for Dendritic Organization in Visual Cortex and Hippocampus　Nelissen TP, Bamford RA, Tochitani S, Akkus K, Kudzinskas A, Yokoi K, Okamoto H, Yamamoto Y, Burbach JPH, Matsuzaki H, Oguro-Ando A.　Neuroscience　372　114-125　2018/02/21
  • 　RAGE-dependent potentiation of TRPV1 currents in sensory neurons exposed to high glucose　Lam D, Momeni Z, Theaker M, Jagadeeshan S, Yamamoto Y, Ianowski JP, Campanucci VA.　PLoS One　13　2　e0193312　2018/02/23
  • 　Anti-tumor effects of a nonsteroidal anti-inflammatory drug zaltoprofen on chondrosarcoma via activating peroxisome proliferator-activated receptor gamma and suppressing matrix metalloproteinase-2 expression　metalloproteinase-2 expression. Higuchi T, Takeuchi A, Munesue S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Inatani H, Shimozaki S, Kato T, Aoki Y, Abe K, Taniguchi Y, Aiba H, Murakami H, Harashima A, Yamamoto Y, Tsuchiya H.　Cancer Med　2018/03/23
  • 　In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system　structure-based drug design system. El-Far AHAM, Munesue S, Harashima A, Sato A, Shindo M, Nakajima S, Inada M, Tanaka M, Takeuchi A, Tsuchiya H, Yamamoto H, Shaheen HME, El-Sayed YS, Kawano S, Tanuma SI, Yamamoto Y.　Oncol Lett　15　4　4627-4634　2018/04/01
  • 　Targeting RAGE: a viable strategy for cancer prevention and treatment?　Munesue S, Yamamoto Y.　IMARS Highlights　12　6　5-6　2017/12/01
  • 　Effects of three lipidated oxytocin analogs on behavioral deficits in CD38 knockout mice　Cherepanov SM, Akther S, Nishimura T, Shabalova AA, Mizuno A, Ichinose W, Satoshi Shuto S, Yamamoto Y, Yokoyama S, Higashida H.　Brain Sci　7　10　E132　2017/10/01
  • 　From insulin synthesis to secretion: alternative splicing of type 2 ryanodine receptor gene is essential for insulin secretion in pancreatic β cells　Okamoto H, Takasawa S, Yamamoto Y.　Int J Biochem Cell Biol　91　176-183　2017/08/01
  • 　Intestinal transepithelial permeability of oxytocin into the blood is dependent on the receptor for advanced glycation end products in mice　Higashida H, Furuhara K, Yamauchi AM, Deguchi K, Harashima A, Munesue S, Lopatina O, Gerasimenko M, Salmina AB, Zhang JS, Kodama H, Kuroda H, Tsuji C, Suto S, Yamamoto H, Yamamoto Y.　Sci Rep　7　1　7883　2017/07/01
  • 　Perception of pathogenic bacteria by pattern recognition receptor RAGE in the frontline　Harashima A, Yamamoto Y.　IMARS Highlights　12　2　5-7　2017/02/01
  • 　Nitration and glycation turn mature NGF into a toxic factor for motor neurons: a role for p75NTR and RAGE signaling in ALS　Kim MJ, Vargas MR, Harlan BA, Killoy KM, Ball L, Comte-Walters S, Gooz M, Yamamoto Y, Beckman JS, Barbeito L, Pehar M.　Antioxid Redox Signal　2017　2017/06/26
  • 　Low-dose paclitaxel suppresses the induction of M2 macrophages in gastric cancer　Yamaguchi T, Fushida S, Yamamoto Y, Tsukada T, Kinoshita J, Oyama K, Miyashita T, Tajima H, Ninomiya I, Munesue S, Harashima A, Harada S, Yamamoto H, Ohta T.　Oncology Rep　37　6　3341-3350　2017/06/01
  • 　CD38 positively regulates postnatal development of astrocytes cell-autonomously and oligodendrocytes non-cell-autonomously　Hattori T, Kaji M, Ishii H, Jureepon R, Takarada-Iemata M, Minh Ta H, Manh Le T, Konno A, Hirai H, Shiraishi Y, Ozaki N, Yamamoto Y, Okamoto H, Yokoyama S, Higashida H, Kitao Y, Hori O.　Glia　65　6　974-89　2017/06/01
  • 　Targeting of RAGE-ligand signaling impairs breast cancer cell invasion and metastasis　Kwak T, Drews-Elger K, Ergonul A, Miller PC, Braley A, Hwang GH, Zhao D, Besser A, Yamamoto Y, Yamamoto H, El-Ashry D, Slingerland JM, Lippman ME, Hudson BI.　Oncogene　36　11　1559-72　2017/11/01
  • 　Contribution of methylglyoxal to delayed healing of bone injury in diabetes　Aikawa T, Matsubara H, Ugaji S, Shirakawa J, Nagai R, Munesue S, Harashima A, Yamamoto Y, Tsuchiya H. 　Mol Med Rep　16　1　402-409　2017/08/01
  • 　Structure-specific effects of lipidated oxytocin analogs on intracellular calcium levels, parental behavior, plasma and cerebrospinal fluid oxytocin concentrations in mice　Cherepanov S, Yokoyama S, Mizuno A, Ichinose W, Lopatina O, Shabalova A, Salmina A, Yamamoto Y, Okamoto H, Shuto S, Higashida H.　Pharmacology Research & Perspectives　5　1　e00290　2017/05/01
  • 　Deletion of RAGE causes hyperactivity and increased sensitivity to auditory stimuli in mice　4　12　8309　2009/12
  • 　Blockade of endothelial-mesenchymal-transition by a Smad3 inhibitor delays the early development of streptozotocin-induced diabetic nephropathy.　DIABETES　2010
  • 　Regulation of alternative splicing of the receptor for advanced glycation endproducts (RAGE) through G-rich cis-elements and heterogenous nuclear ribonucleoprotein (hnRNP) H.　JOURNAL OF BIOCHEMISTRY　147　5　651-659　2010
  • 　Inhibition of allergic bronchial asthma by thrombomodulin is mediated by dendritic cells.　AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE　2010
  • 　Spontaneous bone loss in RIP-iNOS transgenic mouse: A mouse model for diabetes- mediated osteopenia/osteoporosis.　Cell Cycle　8　24　4179-4181　2009
  • 　Glycation of a food allergen by the Maillard reaction enhances its T-cell immunogenicity: the role of macrophage scavenger receptor class A type I and II.　JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY　125　1　175-183　2010
  • 　RAGE mediates oxidized LDL-induced pro-inflammatory effects and atherosclerosis in non-diabetic LDL receptor-deficient mice.　CARDIOVASCULAR RESEARCH　82　2　 371-381　2009/02
  • 　The solution structure of variable-type domain of receptor for advanced glycation endproducts: a new insight into AGE-RAGE interaction.　BIOCHEMISTRY　47　47　 12299-12311　2008
  • 　Neural activity dependent release of S100B from astrocytes enhances kainite-induced gamma oscillations in vivo.　JOURNAL OF NEUROSCIENCE　28　43　 10928-10936　2008
  • 　Reduced expression of endogenous secretory receptor for advanced glycation endproducts in hippocampal neurons of Alzheimer's disease brains.　ARCHIVES OF HISTOLOGY AND CYTOLOGY　70　5　 279-290　2007/05
  • 　De-N-glycosylation or G82S mutation of RAGE sensitizes its interaction with advanced glycation endproducts.　BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS　1770　10　 1468-1474　2007/10
  • 　Assaying soluble forms of receptor for advanced glycation endproducts.　ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY　27　 33-34　2007
  • 　The role of the receptor for advanced glycation end-products in lung fibrosis.　AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY　2007/06
  • 　Endogenous secretory receptor for advanced glycation end-products as a novel prognostic marker in chondrosarcoma.　CANCER　109　12　 2532-2540　2007/12
  • 　Short-chain aldehyde-derived ligands for RAGE and their actions on endothelial cells.　DIABETES RESEARCH AND CLINICAL PRACTICE　S1　 30-40　2007/01
  • 　Inhibition of diabetic leukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products.　INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　48　2　 858-865　2007/02
  • 　Endogenous secretory receptor for advanced glycation endproducts levels are correlated with serum pentosidine and CML in patients with type 1 diabetes.　ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY　27　1　 253-254　2007/01
  • 　Endogenous secretory receptor for advanced glycation end products in non-small cell lung carcinoma.　AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE　175　2　 184-189　2007/02
  • 　Receptor for advanced glycation endproducts is involved in impaired angiogenic response in diabetes.　DIABETES　55　8　 2245-2255　2006/08
  • 　RAGE control of diabetic nephropathy in a mouse model: effects of RAGE gene disruption and administration of low molecular weight heparin.　DIABETES　55　9　 2510-2522　2006/09
  • 　Plasma level of endogenous secretory receptor for advanced glycation endproducts (esRAGE) is associated with components of the metabolic syndrome and atherosclerotic arterial wall thickness.　ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY　25　12　 2587-2593　2005/12
  • 　RAGE is a promising target of diabetic nephropathy.　ANNALS OF THE NEW YORK ACADEMY OF SCIENCES　1013　1-5　2005/06
  • 　The N-terminal domain of thrombomodulin sequesters high mobility group-B1.　JOURNAL OF CLINICAL INVESTIGATION　115　1267-1274　2005/05
  • 　Possible participation of pICln in the regulation of angiogenesis through alternative splicing of VEGF receptor mRNAs.　ENDOTHELIUM-NEW YORK　11　5-6　293-300　2004
  • 　AGE downregulation of monocyte expression of RAGE mRNA and its association with diabetic complications in type 1 diabetes.　JOURNAL OF DIABETES AND ITS COMPLICATIONS　18　53-60　2004/01
  • 　Advanced glycation end products increase collagen-specific chaperone protein in mouse diabetic nephropathy.　JOURNAL OF BIOLOGICAL CHEMISTRY　279　19816-19823　2004/04
  • 　Identification of a novel AGE-capturable soluble variant of the RAGE in human sera.　Excerpta Medical International Congress Series　163-167　2002/10
  • 　RAGE engagement and vascular cell derangement by short chain sugar-derived advanced glycation endproducts.　Excerpta Medical International Congress Series　129-135　2002/10
  • 　The role of AGE-RAGE system in the development of diabetic nephropathy in vivo.　Excerpta Medica International Congress Series　45-50　2002/10
  • 　Advanced glycation endproduct-induced calcium handling impairment in mouse cardiac myocytes.　JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY　34　1425-1431　2002/10
  • 　Novel splice variants of the RAGE expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury.　BIOCHEMICAL JOURNAL　370　3　1097-1109　2003/03
  • 　AGE-deriven angiogenesis in vitro: induction of the growth and tube formation of human microvascular endothelial cells through autocrine VEGF.　JOURNAL OF BIOLOGICAL CHEMISTRY　272　13　8723-8730　1997/04
  • 　The regulation of soluble receptor for AGEs contributes to carbonyl stress in schizophrenia　Miyashita M, Watanabe T, Ichikawa T, Toriumi K, Horiuchi Y, Kobori A, Kushima I, Hashimoto R, Fukumoto M, Koike S, Ujike H, Arinami T, Tatebayashi Y, Kasai K, Takeda M, Ozaki N, Okazaki Y, Yoshikawa T, Amano N, Washizuka S, Yamamoto H, Miyata T, Itokawa M, Yamamoto Y, Arai M　Biochemical and Biophysical Research Communications　2016
  • 　Targeting of RAGE-ligand signaling impairs breast cancer cell invasion and metastasis　Hudson B, Kwak TY, Drews-Elger K, Ergonul A, Braley A, Zhao D, Besser A, El-Ashry D, Slingerland J, Lippman M, Miller P, Yamamoto Y, Yamamoto H, Hwang G　Oncogene　2016
  • 　Clinical relevance of peroxisome proliferator-activated receptor-gamma expression in myxoid liposarcoma　Takeuchi A, Yamamoto N, Shirai T, Hayashi K, Miwa S, Munesue S, Yamamoto Y, Tsuchiya H　BMC Cancer　16　442　2016/07
  • 　Atf6α deficiency suppresses microglial activation and ameliorates pathology of experimental autoimmune encephalomyelitis　Ta H, Le T, Ishii H, Takarada-Iemata M, Hattori, T, Hashida K, Yamamoto Y, Mori K, Takahashi R, Kitao Y, Hori O　J Neurochem　2016/10
  • 　Cyclic ADP-ribose and heat regulate oxytocin release via CD38 and TRPM2 in the hypothalamus during social or psychological stress in mice　Zhong J, Amina S, Liang M, Akther S, Yuhi T, Nishimura T, Higashida C, Tsuji T, Liu HX, Hashii M, Furuhara K, Yokoyama S, Yamamoto Y, Okamoto H, Zhao YJ, Lee HC, Tominaga M, OLopatina O, Higashida H　Front Neurosci　10　304　2016/10
  • 　Adipose natural killer cells regulate adipose tissue macrophages to promote insulin resistance in obesity　Lee BC, Kim MS, Pae M, Yamamoto Y, Eberlé D, Shimada T, Kamei N, Park HS, Sasorith S, Woo JR, You J, Mosher W, Brady HJM, Shoelson SE, Lee J　Cell Metab　23　4　685-698　2016/04
  • 　Modulation of leukotriene B4 receptor 1 signaling by RAGE　Ichiki T, Koga T, Okuno T, Saeki K, Yamamoto Y, Yamamoto H, Sakaguchi M, Yokomizo T　FASEB J　30　5　1811-1822　2016/05
  • 　Tumor-associated macrophages of the M2 phenotype contribute to progression in gastric cancer with peritoneal dissemination　Yamaguchi T, Fushida S, Yamamoto Y, Tsukada T, Kinoshita J, Oyama K, Miyashita T, Tajima H, Ninomiya I, Munesue S, Harashima A, Harada S, Yamamoto H, Ohta T　Gastric Cancer　2015/11
  • 　The receptor for advanced glycation end-products is associated with apoptosis of alveolar epithelial cells in hyperoxia exposure in vitro and in vivo　Ota C, Ishizawa K, Yamada M, Tando Y, Mei H, Takahashi T, Yamamoto Y, Yamamoto H, Kubo H　Respiratory Invest　54　2　98-108　2016/02
  • 　Epidermal expression of receptor for advanced glycation end-products (RAGE) is related to inflammation and apoptosis in human skin　Iwamura M, Yamamoto Y, Kitayama Y, Higuchi K, Fujimura T, Hase T, Yamamoto H　Exp Dermatology　25　3　235-237　2016/03
  • 　RAGE mediates the interactivation of nAChRs in sympathetic neurons during high glucose conditions　Chandna AR, Baskaran MN, Chang C, Pennington PR, Mousseau DD, Yamamoto Y, Campanucci VA　Eur J Neurosci　41　3　341-351　2015/03
  • 　Gadd34 regulates liver regeneration in hepatic steatosis　Inaba Y, Furutani T, Kimura K, Watanabe H, Haga S, Kido Y, Yamamoto Y, Harada K, Kaneko S, Oyadomari S, Ozaki M, Kasuga M, Inoue H　Hepatology　61　4　1343-1356　2015/04
  • 　Emphysema requires the receptor for advanced glycation end products triggering on structural cells　Waseda K, Miyahara N, Taniguchi A, Kurimoto E, Ikeda G, Koga H, Fujii U, Yamamoto Y, Gelfand EW, Yamamoto H, Tanimoto M, Kanehiro A　Am J Respir Cell Mol Biol　52　4　482-491　2015/04
  • 　Contrasting Roles for the Receptor for Advanced Glycation End-Products on Structural Cells in Allergic Airway Inflammation versus Airway Hyperresponsiveness　Taniguchi A, Miyahara N, Waseda K, Kurimoto E, Fuji U, Tanimoto Y, Kataoka M, Yamamoto, Y, Gelfand E, Tanimoto M, Yamamoto H, Kanehiro A　Am J Physiol Lung Cell Mol Physiol　309　8　L789-800　2015/08
  • 　Thrombomodulin modulates dendritic cells via both antagonism of high mobility group protein B1 and an independent mechanism　Toda M, D'Alessandro-Gabazza CN, Takagi T, Chelakkot-Govindalayathila AL, Taguchi O, Roeen Z, Munesue S, Yamamoto Y, Yamamoto H, Gabazza EC, Morser J　Allergology Int　63　1　57-66　2014/01
  • 　Maltitol endows foods with lower 3-deoxyglucosone content and less RAGE agonism as a sweetener against sucrose　Kuretani A, Kawamura R, Munesue S, Yamamoto Y, Honda J, Yamamoto H　Glycative Stress Res　1　2　25-31　2014/02
  • 　Glycyrrhizin inhibits traumatic brain injury in rats by reducing HMGB1-RAGE interaction　Okuma Y, Liu K, Wake H, Liu R, Nishimura Y, Hui Z, Teshigawara K, Haruma J, Yamamoto Y, Yamamoto H, Date I, Takahashi HK, Mori S, Nishibori M　Neuropharmacology　85　18-26　2014/07
  • 　cAMP ameliorates inflammation in macrophages by modulation of receptor for advanced glycation end-products　Motoyoshi S, Yamamoto Y, Munesue S, Igawa H, Harashima A, Saito H, Han H, Watanabe T, Sato H, Yamamoto H　Biochem J　463　1　72-82　2014/01
  • 　Longistatin secreted with tick saliva blocks RAGE　Anisuzzaman, Hatta T, Miyoshi T, Mtsubayashi M, Islam MK, Alim MA, Anas MA, Hasan MM, Matsumoto Y, Yamamoto Y, Yamamoto H, Fujisaki K, Tsuji N　J Clin Invest　124　10　4429-4444　2014/10
  • 　Expression of RAGE by tumor macrophages promotes angiogenesis in gliomas　Chen X, Zhang L, Zhang IY, Liang J, Wang H, Ouyang M, Wu S, da Fonseca ACC, Weng L, Yamamoto Y, Yamamoto H, Natarajan R, Badie B　Cancer Res　74　24　7285-7297　2014/08
  • 　Sivelestat sodium hydrate inhibits neutrophil migration to the vessel wall and suppresses hepatic ischemia-reperfusion injury　Sakai S, Tajima H, Miyashita T, Nakanuma SI, Makino I, Hayashi H, Nakagawara H, Kitagawa H, Fushida S, Fujimura T, Saito H, Munesue S, Yamamoto Y, Ohta T　Dig Dis Sci　59　4　787-794　2014/04
  • 　Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis　Harada K, Kakuda Y, Sato Y, Ikeda H, Shimoda S, Yamamoto Y, Inoue H, Ohta H, Kasashima S, Kawashima A, Nakanuma Y　J Clin Pathol 　67　5　396-402　2014/05
  • 　CD38 in the nucleus accumbens and oxytocin are related to paternal behavior in mice　Akther S, Korshnova N, Zhong J, Liang M, Cherepanov SM, Lopatina O, Komleva YK, Salmina AB, Nishimura T, Fakhrul AAKM, Hirai H, Kato I, Yamamoto Y, Takasawa S, Okamoto H, Higashida H　Mol Brain　6　41　2013/06
  • 　Regulation of diet-induced adipose tissue and systemic inflammation by salicylates and pioglitazone　Kim MS, Yamamoto Y, Kim K, Kamei N, Shimada T, Liu L, Moore K, Woo JR, Shoelson SE, Lee J　PLoS ONE　8　12　e82847　2013/08
  • 　The first case of IDDM with prominent spurious hyperglucagonemia due to interference of IgG in glucagon RIA (OAL-123).　HORMONE RESEARCH　45　295-299　1996/03
  • 　CD38 disruption impairs glucose-induced increases in cyclic ADP-ribose, [Ca2+]i,and insulin secretion.　J. Biol. Chem.　274　4　1869-1872　1999/01
  • 　Relationship between interindividual differences of nicotine metabolism and CYP2A6 genetic polymorphism in humans.　Clin. Pharmacol. Ther.　69　1　72-78　2001/01
  • 　Placenta growth factor and vascular endothelial growth factor B and C expressions in microvascular endothelial cells and pericytes: implication in autocrine and paracrine regulation of angiogenesis.　J. Biol. Chem.　274　49　35172-35178　1999/12
  • 　Molecular heterogeneity of the receptor for advanced glycation endproducts.　J. Biochem. Mol. Biol. Biophys.　4　373-381　2000
  • 　Insulin stimulates the growth and tube formation of human microvascular endothelial cells through autocrine vascular endothelial growth factor.　Microvasc. Res.　57　3　329-339　1999/05
  • 　Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice.　J. Clin. Invest.　108　2　261-268　2001/07
  • 　Advanced glycation endproducts inhibit prostacyclin production and induce plasminogen activator inhibitor-1 in human microvascular endothelial cells.　DIABETOLOGIA　41　12　1435-1441　1998/12
  • 　Inhibitory effect of cyclosporin A on prolactin synthesis in GH3 cells.　TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　180　337-346　1996/02
  • 　Antisense display - A new method for functional gene screen and its application to angiogenesis-related gene isolation.　Ann. N. Y. Acad. Sci.　947　382-386　2001/12
  • 　Advanced glycosylation end products could not only stimulate the growth , but also inhibit the prostacyclin-producing ability of endothelial cells.　FEBS LETTERS　384　103-106　1996/02
  • 　Receptor-mediated toxicity to pericytes of advanced glycosylation end products: a possible mechanism of pericyte loss in diabetic microangiopathy.　BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　213　2　681-687　1995/02
  • 　Spinal cord compression by heterotopic ossification associated with Pseudohypoparathyroidism.　JOURNAL OF INTERNATIONAL MEDICAL RESEARCH　25　364-368　1997/03
  • 　Advanced glycation endproducts-receptor interactions stimulate the growth of human pancreatic cancer cells through the induction of PDGF-B.　BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　222　3　700-703　1996/07
  • 　Roles of the AGE-RAGE system in vascular injury in diabetes.　Ann. N. Y. Acad. Sci.　902　163-172　2000/05
  • 　Vascular endothelial growth factor acts as a pericyte mitogen under hypoxic conditions.　Lab. Invest.　79　4　501-509　1999/04
  • 　The receptor for advanced glycation endproducts is induced by the glycation products themselves and TNF-a through NF-kB, and by 17b-estradiol through Sp-1 in human vascular endothelial cells.　J. Biol. Chem.　275　33　25781-25790　2000/08

Conference Presentations

  • Glycation reaction and the receptor for advanced glycation end-products (RAGE): foe or friend for life?(conference：22nd IUNS-ICN)(2022/12/10)
  • RAGE: a pattern-recognition receptor(conference：12th International congress on amino acids, peptides and proteins)(2011/08/01)
  • RAGE: a pattern-recognition receptor(conference：International Guest Lecture for the Scientific Community of the University of Barcelona)(2012/02/23)
  • AGE, diabetes and its vascular complications(conference：International Conference on Diabetes and Metabolism 2012)(2012/11/09)

Others

  • 　AGE and endothelial cells.　4　4　141-143　1998
  • 　Roles of AGE-RAGE system in vascular injury in diabetes.　902　163-172　2000/03
  • 　The AGE-RAGE System and Diabetic Nephropathy.　14　Suppl3　S259-263　2003/08
  • 　Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice.　1　1　32-33　2002/05
  • 　Nurture vs. nature in diabetic vasculopathy: role of advanced glycation endproducts and the receptor for them.　Elsevier　1262　164-167　2004/04

show all

  • 　Roles of the receptor for advanced glycation endproducts in diabetes-induced vascular injury.　97　305-311　2005/03
  • 　Blockage of diabetic vascular injury by controlling of AGE-RAGE system.　6　4　 447-452　2005//6
  • 　RAGE in diabetic nephropathy.　7　8　 752-757　2007//8
  • 　Significance of advanced glycation endproducts (AGEs) in aging-related disease.　2010

Arts and Fieldwork

Patent

Theme to the desired joint research

○Prevention of development of diabetic complications
○animal models of diabetic nephropathy
○Role of endogenous secretory RAGE (esRAGE) in human diseases
○Transporter of hormones
○Molecular mechanisms in the development of cancer stem-like cells
○Drugs targeting RAGE

Grant-in-Aid for Scientific Research

○「愛情ホルモン・オキシトシンによる炎症免疫抑制作用の分子基盤の解明」(2021-2023)　
○2023「リンパ管のin vitroモデル構築とリンパ浮腫治療法開発の基礎研究」(2020-2023)　
○「糖尿病による骨癒合遅延を解消する挑戦的治療の開発」(2019-2021)　
○「胚シグナルに対する免疫応答異常を共通の病因とする新しい疾患群の同定と解析」(2019-2020)　
○「リンパ浮腫に対する培養リンパ管移植の効果と瘢痕組織のリンパ管再生阻害の基礎研究」(2018-2020)　
○「オキシトシンの血液脳関門移行に関わる分子装置の解明と愛情の構築研究」(2018-2020)　
○「骨肉腫幹細胞モデルにおけるmiR-35aの役割と治療ターゲットの可能性の解析」(2018-2020)　
○「頭脳循環を加速する戦略的国際研究ネットワーク推進プログラム 「慢性炎症と線維化をきたす生体ネットワークの解明とその制御の国際研究拠点形成」 」(2017-2019)　
○「RAGEにより誘導される骨肉腫幹細胞モデルの確立とその分子機構の解明」(2015-2017)　
○「RAGE欠損によりマウス養育行動異常が生じるメカニズムの解明」　
○「関節リウマチ滑膜の上皮間葉移行の分子機構の解析と新規治療法への応用」(2015-2017)　
○「糖化ストレス消去系酵素の転写発現調節機構の解明」
○「食品に含まれるRAGEシグナル阻害成分の同定と阻害機構の解明」(2014-2016)
○「2型糖尿病の膵β細胞不全におけるRAGE・糖脂肪毒性・レプチンの役割の解明 」(2013-2016)　
○「スンクスにおける脂肪幹細胞の分布と分化能の解析」(2013-2016)　
○「パターン認識受容体の切断により糖尿病血管合併症を制御する」(2012-2014)　
○「新規血管保護因子-分泌型RAGEの発現機構と病態生理の解明」(2007-2010)　
○「マルチリガンド受容体RAGEによる細胞内シグナル生成機構の解明」(2006-)　
○「血管新生・糖尿病血管症罹患感受性を制御する選択的mRNAスプライシングの新機構」(2005-)　
○「内在性分泌型RAGEタンパクの病原微生物に対する防御作用」(2004-)　
○「多機能受容体RAGEのシグナリングネットワークの解明」(2004-)　
○「新規糖化蛋白質分子種による血管障害機序の解明」(2002-)　
○「グライコミクスによる糖尿病合併症発症の新機序の解明」(2005-)　
○「グライコミクスによる糖尿病合併症発症の新機序の解明」(2004-)　
○「遺伝子ターゲティングによる糖尿病血管合併症の原因・治療の解明」(2003-)　
○「遺伝子ターゲティングによる糖尿病血管合併症の原因・治療の解明」(2002-)　
○「発生工学的手法を用いた糖尿病性血管合併症発症機構の解明」(2001-)　
○「糖化蛋白レセプター（RAGE）情報伝達系の解明―糖尿病性血管病変発生の新機構」(2001-)　
○「新しい機能性遺伝子同定技術の創出と成人病性血管障害関連遺伝子探索への応用」(2000-)　
○「発生工学的手法を用いた糖尿病性血管合併症発症機構の解明」(2000-)　

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Presentation and Debate (Freshman Seminar II)(2017)
○Introduction to Region-studies(2017)
○Presentation and Debate (Freshman Seminar II)(2017)
○Basic Health Science(2017)
○Biochemistry2(2017)
○Practical Medical Research(2017)
○Molecular Basis of the Cell Functions(2016)
○Presentation and Debate (Freshman Seminar II)(2016)
○Basic Health Science(2016)
○Introduction to Region-studies(2016)

Classes (Graduate Schools)

○Fostering the Independence of Researchers(2017)
○Molecular Biology of the Cardiovascular System(2017)
○BIOETHICS(2017)
○Molecular Biology of the Cardiovascular System(2017)
○Molecular Biology of the Cardiovascular System(2017)
○Introduction to Basic Medical Science(2016)
○Molecular Biology of the Cardiovascular System(2016)
○Molecular Biology of the Cardiovascular System(2016)
○Molecular Biology of the Cardiovascular System(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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