last modified：2025/12/05
Associate Professor WAKASUGI Mitsuo
Faculty, Affiliation
Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences
College and School Educational Field
Division of Health Sciences, Graduate School of Phamaceutical Science
Division of Pharmaceutical Sciences, Graduate School of Medical Science
School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences
School of Pharmacy, College of Medical, Pharmaceutical and Health Sciences
Laboratory
Laboratory of Molecular Human Genetics TEL:076-234-4426 FAX:076-234-4427
Academic Background
【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor Graduate School of Natural Science & Tec Division of Life Sciences 199603 Completed
Career
Kanazawa University Faculty of Pharmaceutical Sciences(2002/04/01-)
Year & Month of Birth
1969/03
Academic Society
Award
Specialities
DNA repair Genomic instability Cancer prevention、Risk sciences of radiation and chemicals、Biological pharmacy、Molecular biology
Speciality Keywords
DNA repair Damage response
Research Themes
Molecular mechanism of nucleotide excision repair
Books
Papers
- Epitope-Based Specific Antibody Modifications. Saki Horie,Kenji Mishiro,Mio Nishino,Inori Domae,Mitsuo Wakasugi,Tsukasa Matsunaga,Munetaka Kunishima Bioconjugate chemistry 34 11 2022 2023/11/15
- UVA causes specific mutagenic DNA damage through ROS production, rather than CPD formation, in Drosophila larvae Tomoe Negishi,Fang Xing,Ryota Koike,Manami Iwasaki,Mitsuo Wakasugi,Tsukasa Matsunaga Mutation Research/Genetic Toxicology and Environmental Mutagenesis 887 503616 2023/04
- Mapping of the regions implicated in nuclear localization of multi‐functional
DNA repair endonucleaseXPF‐ERCC1 Ryo Akahori,Chie Takamori,Mitsuo Wakasugi,Tsukasa Matsunaga Genes to Cells 27 5 356 2022/05
- Camptothecin compromises transcription recovery and cell survival against cisplatin and ultraviolet irradiation regardless of transcription-coupled nucleotide excision repair. Ryo Sakasai,Mitsuo Wakasugi,Tadashi Matsui,Yumi Sunatani,Masafumi Saijo,Tsukasa Matsunaga,Kuniyoshi Iwabuchi DNA repair 113 103318 2022/03/10
- Topoisomerase I-driven repair of UV-induced damage in NER-deficient cells Liton Kumar Saha,Mitsuo Wakasugi,Salma Akter,Rajendra Prasad,Samuel H. Wilson,Naoto Shimizu,Hiroyuki Sasanuma,Shar-yin Naomi Huang,Keli Agama,Yves Pommier,Tsukasa Matsunaga,Kouji Hirota,Shigenori Iwai,Yuka Nakazawa,Tomoo Ogi,Shunichi Takeda Proceedings of the National Academy of Sciences 201920165 2020/06/08
- DCAF7 is required for maintaining the cellular levels of ERCC1-XPF and nucleotide excision repair Hiroaki Kawara,Ryo Akahori,Mitsuo Wakasugi,Aziz Sancar,Tsukasa Matsunaga Biochemical and Biophysical Research Communications 519 1 204 2019/10
- Spironolactone-induced XPB degradation depends on CDK7 kinase and SCFFBXL18 E3 ligase Ueda, Masanobu,Matsuura, Kenkyo,Kawai, Hidehiko,Wakasugi, Mitsuo,Matsunaga, Tsukasa GENES TO CELLS 24 4 284 2019/04
- PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching Tsuda, Masataka,Ogawa, Saki,Ooka, Masato,Kobayashi, Kaori,Hirota, Kouji,Wakasugi, Mitsuo,Matsunaga, Tsukasa,Sakuma, Tetsushi,Yamamoto, Takashi,Chikuma, Shunsuke,Sasanuma, Hiroyuki,Debatisse, Michelle,Doherty, Aidan J,Fuchs, Robert P,Takeda, Shunichi PLOS ONE 14 3 2019/03/06
- Aquarius is required for proper CtIP expression and homologous recombination repair Ryo Sakasai,Mayu Isono,Mitsuo Wakasugi,Mitsumasa Hashimoto,Yumi Sunatani,Tadashi Matsui,Atsushi Shibata,Tsukasa Matsunaga,Kuniyoshi Iwabuchi SCIENTIFIC REPORTS 7 2017/10
- Nucleotide Excision Repair-dependent DNA Double-strand Break Formation and ATM Signaling Activation in Mammalian Quiescent Cells Mitsuo Wakasugi,Takuma Sasaki,Megumi Matsumoto,Miyuki Nagaoka,Keiko Inoue,Manabu Inobe,Katsuyoshi Horibata,Kiyoji Tanaka,Tsukasa Matsunaga JOURNAL OF BIOLOGICAL CHEMISTRY 289 41 28730 2014/10
- The scaffold protein JLP plays a key role in regulating ultraviolet B-induced apoptosis in mice Radnaa Enkhtuya,Tokiharu Sato,Mitsuo Wakasugi,Baljinnyam Tuvshintugs,Hirofumi Miyata,Takeshi Sakurai,Tsukasa Matsunaga,Katsuji Yoshioka GENES TO CELLS 19 4 350 2014/04
- Role of Interaction of XPF with RPA in Nucleotide Excision Repair Laura A. Fisher,Mika Bessho,Mitsuo Wakasugi,Tsukasa Matsunaga,Tadayoshi Bessho JOURNAL OF MOLECULAR BIOLOGY 413 2 337 2011/10
- Establishment of a Microplate-Formatted Cell-Based Immunoassay for Rapid Analysis of Nucleotide Excision Repair Ability in Human Primary Cells Mari Nishinaga,Ryuichiro Kurata,Kazuyoshi Onishi,Kenichi Kuriyama,Mitsuo Wakasugi,Tsukasa Matsunaga PHOTOCHEMISTRY AND PHOTOBIOLOGY 88 2 356 2012/03
- The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation. Eric S Fischer,Andrea Scrima,Kerstin Böhm,Syota Matsumoto,Gondichatnahalli M Lingaraju,Mahamadou Faty,Takeshi Yasuda,Simone Cavadini,Mitsuo Wakasugi,Fumio Hanaoka,Shigenori Iwai,Heinz Gut,Kaoru Sugasawa,Nicolas H Thomä Cell 147 5 1024 2011/11/23
- Physical and functional interaction between DDB and XPA in nucleotide excision repair Mitsuo Wakasugi,Hiromi Kasashima,Yuko Fukase,Mayumi Imura,Rika Imai,Saki Yamada,James E. Cleaver,Tsukasa Matsunaga NUCLEIC ACIDS RESEARCH 37 2 516 2009/02
- DDB1 gene disruption causes a severe growth defect and apoptosis in chicken DT40 cells Mitsuo Wakasugi,Kenkyo Matsuura,Atsushi Nagasawa,DongTao Fu,Hiroko Shimizu,Ken-ichi Yamamoto,Shunichi Takeda,Tsukasa Matsunaga BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 364 4 771 2007/12
- Cleavage-mediated activation of Chk1 during apoptosis Kenkyo Matsuura,Mitsuo Wakasugi,Katsumi Yamashita,Tsukasa Matsunaga JOURNAL OF BIOLOGICAL CHEMISTRY 283 37 25485 2008/09
- Human XPC-hHR23B interacts with XPA-RPA in the recognition of triplex-directed psoralen DNA interstrand crosslinks BS Thoma,M Wakasugi,J Christensen,MC Reddy,KM Vasquez NUCLEIC ACIDS RESEARCH 33 9 2993 2005
- Human NTH1 physically interacts with p53 and proliferating cell nuclear antigen M Oyama,M Wakasugi,T Hama,H Hashidume,Y Iwakami,R Imai,S Hoshino,H Morioka,Y Ishigaki,O Nikaido,T Matsunaga BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 321 1 183 2004/08
- CDNA cloning of the chicken DDB1 gene encoding the p127 subunit of damaged DNA-binding protein DT Fu,M Wakasugi,Y Ishigaki,O Nikaido,T Matsunaga GENES & GENETIC SYSTEMS 78 2 169 2003/04
- DDB accumulates at DNA damage sites immediately after UV irradiation and directly stimulates nucleotide excision repair M Wakasugi,A Kawashima,H Morioka,S Linn,A Sancar,T Mori,O Nikaido,T Matsunaga JOURNAL OF BIOLOGICAL CHEMISTRY 277 3 1637 2002/01
- Damaged DNA-binding protein DDB stimulates the excision of cyclobutane pyrimidine dimers in vitro in concert with XPA and replication protein A M Wakasugi,M Shimizu,H Morioka,S Linn,O Nikaido,T Matsunaga JOURNAL OF BIOLOGICAL CHEMISTRY 276 18 15434 2001/05
- Order of assembly of human DNA repair excision nuclease M Wakasugi,A Sancar JOURNAL OF BIOLOGICAL CHEMISTRY 274 26 18759 1999/06
- Mutational analysis of a function of xeroderma pigmentosum group A (XPA) protein in strand-specific DNA repair T Kobayashi,S Takeuchi,M Saijo,Y Nakatsu,H Morioka,E Otsuka,M Wakasugi,O Nikaido,K Tanaka NUCLEIC ACIDS RESEARCH 26 20 4662 1998/10
- Assembly, subunit composition, and footprint of human DNA repair excision nuclease M Wakasugi,A Sancar PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 95 12 6669 1998/06
- Characterization of reaction intermediates of human excision repair nuclease D Mu,M Wakasugi,DS Hsu,A Sancar JOURNAL OF BIOLOGICAL CHEMISTRY 272 46 28971 1997/11
- The non-catalytic function of XPG protein human nucleotide excision repair M Wakasugi,JT Reardon,A Sancar JOURNAL OF BIOLOGICAL CHEMISTRY 272 25 16030 1997/06
- Purification of a novel UV-damaged-DNA binding protein highly specific for (6-4) photoproduct M Wakasugi,Y Abe,Y Yoshida,T Matsunaga,O Nikaido NUCLEIC ACIDS RESEARCH 24 6 1099 1996/03
- Rodent complementation group 8 (ERCC8) corresponds to Cockayne syndrome complementation group A T Itoh,T Shiomi,N Shiomi,Y Harada,M Wakasugi,T Matsunaga,O Nikaido,EC Friedberg,M Yamaizumi MUTATION RESEARCH-DNA REPAIR 362 2 167 1996/02
Conference Presentations
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「ヌクレオチド除去修復におけるDDBの機能とクロマチン構造変換機構の解析」(2004-)
○「ヌクレオチド除去修復におけるクロマチン制御とDDBの機能」(2006-)
○「ゲノム損傷応答機構におけるＣｕｌ４／ＤＤＢ１ユビキチンリガーゼの新機能の解明」(2009-)
○「休止期においてＮＥＲ依存的に活性化するＤＮＡ損傷応答機構の解析」(2012-2014)
○「休止期のヌクレオチド除去修復により生じる二次的DNA損傷とゲノム恒常性維持機構」(2015-2017)
○「NER中間体がもたらす新たなDNA損傷生成とその防御応答の解析」(2019-2021)
○「ヌクレオチド除去修復機構解明に向けたケミカルアプローチ」(2019-2021)
○「NER反応中間体のプロセッシングと生物影響の解明」(2023-2025)
○「BioID法を利用したヌクレオチド除去修復反応の高精細・動的モデルの構築」(2023-2025)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Molecular and Cellular Biology 3(2017)
○Advanced Molecular Cell Biology(2017)
○Presentation and Debate (Freshman Seminar II)(2017)
○Molecular and Cellular Biology 3(2016)
○Advanced Molecular Cell Biology(2016)
Classes (Graduate Schools)
○Advanced Seminar on Biopharmaceutical Sciences(2017)