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Researcher Information

last modified：2024/11/22

Associate Professor　DEMURA, Masashi

Mail

Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

　TEL:076-265-2213　FAX:076-234-4232

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University　Doctor　Graduate School, Division of Medical Sciences　200203　Completed
【Degree】
Doctor of Medical Science (DMSc)

Career

Kanazawa University(2009/08/01-)
Kanazawa University Hospital(2008/04/01-)
Northwestern University　Research Associate(2003/10/01-2006/10/10)
Kanazawa University Hospital(1995/05/01-1996/03/29)

Year & Month of Birth

Academic Society


Japan Endcorine Society




Award

○3rd IAF-J award(2010/05/16)
○Young Investigator Award for International Symposium for Aldosterone and Related Substa(2010/03/24)
○Research presentation award from 4th Workshop on Hypertension and Coronary Artery Disease(2009/12/26)
○Travel Grant Award (ESH2009)(2009/06/12)
○The 2nd IAF-J awrad(2009/05/17)
○The Northwestern Memorial Foundation MD-Scientist Fellowship in Genetic Medicine(2006/04/01)
○Center for Genetic Medicine of Northwestern University(2005/06/15)
○the Gordon Research Conference on Hormone Action in Development and Cancer(2005/06/15)
○Travel grant award (ENDO2003)(2003/06/20)
○Travel grant award (ENDO2003)(2003/06/20)

Specialities

Endocrinology

Speciality Keywords

epigenetics,autoimmune,renin-angiotesin-aldosterone system,Endocrinology

Research Themes

Molecular genetic mechanism in aldosterone production from cardiovascular tissues

Identification of target genes for aldosterone/mineralocorticoid receptor

Books

  • 　Demura M, Saijoh K　Adv Exp Med Biol - Advances in Internal Medicine 　2017
  • 　Takeda, Y., Demura, M., Yoneda, T.　Molecular Genetics, Endocrinology, and Translational Medicine　2014/01

Papers

  • 　Regulation of serine protease inhibitor Kazal type-5 (SPINK5) gene expression in the keratinocytes. 　Le NA, Katsuyama M, Demura M, Tanii H, Katsuyama H, Saijoh K. 　Environ Health Prev Med　19　4　307-313　2014
  • 　Repeated Exposure to Cruciferous Allyl Nitrile Protects against Chemically Induced Skin Inflammation in the Mouse.　Hideji Tanii, Tomomi Higashi, Masashi Demura, Kiyofumi Saijoh　Food and Nutrition Sciences　3　8　1037-42　2012/08
  • 　A Humanized Pattern of Aromatase Expression Is Associated with Mammary Hyperplasia in Mice.　Zhao H,Pearson EK,Brooks DC,Coon V JS,Chen D,Demura M,Zhang M,Clevenger CV,Xu X,Veenstra TD,Chatterton RT,Demayo FJ,Bulun SE　ENDOCRINOLOGY　153　6　2701-13　2012/06
  • 　Unilateral primary aldosteronism with spontaneous remission after long-term spironolactone therapy.　Yoneda T,Demura M,Takata H,Kometani M,Karashima S,Yamagishi M,Takeda Y　J Clin Endocrinol Metab　97　4　1109-13　2012/04
  • 　Protective effects of mineralocorticoid receptor blockade against neuropathy in experimental diabetic rats.　Takata H,Takeda Y,Zhu A,Cheng Y,Yoneda T,Demura M,Yagi K,Karashima S,Yamagishi M　Diabetes Obes Metab　14　2　155-62　2012/02

show all

  • 　Clinical characteristics of primary hyperaldosteronism due to adrenal microadenoma.　Karashima S,Takeda Y,Cheng Y,Yoneda T,Demura M,Kometani M,Ohe M,Mori S,Yagi K,Yamagishi M　Steroids　76　12　1363-6　2011/12
  • 　Changes in aromatase (CYP19) gene promoter usage in non-small cell lung cancer.　LUNG CANCER　2011/01
  • 　A possible new syndrome with double endocrine tumors in association with an unprecedented type of familial heart-hand syndrome: a case report.　Demura M,Yoneda T,Karashima S,Higashikata T,Mabuchi H,Kawano M,Yamagishi M,Takeda Y　J Med Case Reports　4　347　2010/10
  • 　Ectopic Production of Parathyroid Hormone in a Patient with Sporadic Medullary Thyroid Cancer.　ENDOCRINE JOURNAL　57　161-70　2010/01
  • 　High aromatase expression in uterine leiomyoma tissues of African-American women.　Ishikawa H, Reierstad S, Demura M, Rademaker AW, Kasai T, Inoue M, Usui H, Shozu M, Bulun SE.　JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM　94　5　1752-6　2009/05
  • 　Novel Promoter I.8 and Promoter Usage in the CYP19 (Aromatase) Gene. 　Demura M, Reierstad S, Innes JE, Bulun SE.　Reprod Science　15　10　1044-53　2008/12
  • 　CpG dinucleotide methylation of the CYP19 I.3/II promoter modulates cAMP-stimulated aromatase activity.　Demura M,Bulun SE　Mol Cell Endocrinol　283　1-2　127-32　2008/02
  • 　Regional rearrangements in chromosome 15q21 cause formation of cryptic promoters for the CYP19 (aromatase) gene.　Demura M,Martin RM,Shozu M,Sebastian S,Takayama K,Hsu WT,Schultz RA,Neely K,Bryant M,Mendonca BB,Hanaki K,Kanzaki S,Rhoads DB,Misra M,Bulun SE　Hum Mol Genet　16　21　2529-41　2007/11
  • 　Aromatase excess in cancers of breast, endometrium and ovary.　Bulun SE,Chen D,Lu M,Zhao H,Cheng Y,Demura M,Yilmaz B,Martin R,Utsunomiya H,Thung S,Su E,Marsh E,Hakim A,Yin P,Ishikawa H,Amin S,Imir G,Gurates B,Attar E,Reierstad S,Innes J,Lin Z　J Steroid Biochem Mol Biol　106　1-5　81-96　2007/08
  • 　Aromatase excess in cancers of breast, endometrium and ovary.　Bulun SE, Lin Z, Imir G, Amin S, Demura M, Yilmaz B, Martin R, Utsunomiya H, Thung S, Gurates B, Tamura M, Langoi D, Deb S. 　PHARMACOLOGICAL REVIEWS　57　3　359-83　2005/09
  • 　Surgical stress-induced transient nephrogenic diabetes insipidus (NDI) associated with decreased Vasopressin receptor2 (AVPR2) expression linked to nonsense-mediated mRNA decay and incomplete skewed X-inactivation in a female patient with a heterozygous AVPR2 mutation (c. 89-90 delAC).　Demura M,Takeda Y,Yoneda T,Oda N,Bando Y,Mabuchi H　Clin Endocrinol (Oxf)　60　6　773-5　2004/06
  • 　Completely skewed X-inactivation in a mentally retarded young female with pseudohypoparathyroidism type IB and juvenile renin-dependent hypertension.　Demura M,Takeda Y,Yoneda T,Furukawa K,Tachi A,Mabuchi H　J Clin Endocrinol Metab　88　7　3043-9　2003/07
  • 　19-Noraldosterone in pregnancy-induced hypertension.　Takeda Y,Yoneda T,Demura M,Furukawa K,Usukura M,Mabuchi H　STEROIDS　67　7　605-10　2002/07
  • 　Genetic analysis of the cytochrome P-450c17alpha (CYP17) and aldosterone synthase (CYP11B2) in Japanese patients with 17alpha-hydroxylase deficiency.　Takeda Y,Yoneda T,Demura M,Furukawa K,Koshida H,Miyamori I,Mabuchi H　Clin Endocrinol (Oxf)　54　6　751-8　2001/06
  • 　Effects of high sodium intake on cardiovascular aldosterone synthesis in stroke-prone spontaneously hypertensive rats.　Takeda Y, Yoneda T, Demura M, Furukawa K, Miyamori I, Mabuchi H.　JOURNAL OF HYPERTENSION　19　3 Pt2　635-9　2001/03
  • 　Sodium-induced cardiac aldosterone synthesis causes cardiac hypertrophy.　Takeda Y,Yoneda T,Demura M,Miyamori I,Mabuchi H　ENDOCRINOLOGY　141　5　1901-4　2000/05
  • 　Cardiac aldosterone production in genetically hypertensive rats.　Takeda Y,Yoneda T,Demura M,Miyamori I,Mabuchi H　HYPERTENSION　36　4　495-500　2000/04
  • 　Effect of potassium on DNA methylation of aldosterone synthase gene　Takeda, Yoshimichi Demura, Masashi Wang, Fen Karashima, Shigehiro Yoneda, Takashi Kometani, Mitsuhiro Aomo, Daisuke Hashimoto, Atsushi Horike, Shin-ichi Meguro-Horike, Makiko Takeda, Yoshiyu　Journal of Hypertension　39　5　2021/05/03
  • 　A case of renovascular hypertension with incidental primary bilateral macronodular adrenocortical hyperplasia.　Higashitani, Takuya Karashima, Shigehiro Aono, Daisuke Konishi, Seigoh Kometani, Mitsuhiro Oka, Rie Demura, Masashi Furukawa, Kenji Yamazaki, Yuto Sasano, Hironobu Yoneda, Takashi Takeda, Yoshiyu　Endocrinology, diabetes & metabolism case reports　2020　1　1-6　2020/08/06
  • 　Impact of Gut Microbiome on Hypertensive Patients With Low-Salt Intake: Shika Study Results.　Nagase, Satoshi Karashima, Shigehiro Tsujiguchi, Hiromasa Tsuboi, Hirohito Miyagi, Sakae Kometani, Mitsuhiro Aono, Daisuke Higashitani, Takuya Demura, Masashi Sakakibara, Hiroyuki Yoshida, Akihiro Hara, Akinori Nakamura, Hiroyuki Takeda, Yoshiyu Nambo, Hidetaka Yoneda, Takashi Okamoto, Shigefumi　Frontiers in medicine　7　475　2020/09/02
  • 　Impact of mineralocorticoid receptor blockade with direct renin inhibition in angiotensin II-dependent hypertensive mice　Hashimoto, Atsushi Takeda, Yoshimichi Karashima, Shigehiro Kometani, Mitsuhiro Aono, Daisuke Demura, Masashi Higashitani, Takuya Konishi, Seigo Yoneda, Takashi Takeda, Yoshiyu　Hypertens Res.　2020/10/01
  • 　Renal artery aneurysm due to fenestration of a branch of the renal artery: A case study　Karashima, S. Kometani, M. Aono, D. Higashitani, T. Nishimoto, Y. Konishi, S. Demura, M. Takeda, Y. Yoneda, T.　Journal of the Endocrine Society　5　2　2021/02/01
  • 　Effect of sodium–glucose cotransporter-2 inhibitors on aldosterone-to-renin ratio in diabetic patients with hypertension: a retrospective observational study　Sawamura, Toshitaka Karashima, Shigehiro Nagase, Satoshi Nambo, Hidetaka Shimizu, Eiko Higashitani, Takuya Aono, Daisuke Ohbatake, Azusa Kometani, Mitsuhiro Demura, Masashi Furukawa, Kenji Takeda, Yoshiyu Yoneda, Takashi　BMC Endocrine Disorders　20　1　2020/12/01
  • 　Pregnancy-associated diabetes insipidus in Japan—a review based on quoting from the literatures reported during the period from 1982 to 2019　Takeda, Ryoyu Demura, Masashi Sugimura, Yoshihisa Miyamori, Isamu Konoshita, Tadashi Yamamoto, Hiroshi　Endocrine Journal　EJ20-0745　2021/04/01
  • 　Primary aldosteronism subtype discordance between computed tomography and adrenal venous sampling.　Aono D, Kometani M, Karashima S, Usukura M, Gondo Y, Hashimoto A, Demura M, Furukawa K, Takeda Y, Kawashiri M, Yoneda T.　Hypertens Res.　2019/08/13
  • 　Genetic and epigenetic analyses of aldosterone-producing adenoma with hypercortisolemia.　Kometani M, Yoneda T, Demura M, Aono D, Gondoh Y, Karashima S, Nishimoto K, Yasuda M, Horike SI, Takeda Y.　Steroids.　2019/08/07
  • 　Severe Mitral Regurgitation As a Result of Rupture of Mitral Valve Chordae Tendineae in a Patient With Graves Disease.　Karashima S, Tsuda T, Kometani M, Oka R, Demura M, Kawashiri MA, Takeda Y, Hayashi K, Yoneda T.　J Endocr Soc.　2　11　1246-1250　2018/09/17
  • 　Impact of aldosterone-producing cell clusters on diagnostic discrepancies in primary aldosteronism.　Kometani M, Yoneda T, Aono D, Karashima S, Demura M, Nishimoto K, Yamagishi M, Takeda Y.　Oncotarget　9　40　26007-26018　2018/05
  • 　Epigenetic Regulation of Aldosterone Synthase Gene by Sodium and Angiotensin II.　Takeda Y, Demura M, Wang F, Karashima S, Yoneda T, Kometani M, Hashimoto A, Aono D, Horike SI, Meguro-Horike M, Yamagishi M, Takeda Y.　JAHA　7　10　e008281　2018/05
  • 　Effect of sodium glucose cotransporter 2 inhibitors on obstructive sleep apnea in patients with type 2 diabetes.　Sawada K, Karashima S, Kometani M, Oka R, Takeda Y, Sawamura T, Fujimoto A, Demura M, Wakayama A, Usukura M, Yagi K, Takeda Y, Yoneda T.　Endocr J　2018/04
  • 　Ventricular Fibrillation Associated With Dynamic Changes in J-Point Elevation in a Patient With Silent Thyroiditis.　Karashima S, Tsuda T, Wakabayashi Y, Kometani M, Demura M, Ichise T, Kawashiri MA, Takeda Y, Hayashi K, Yoneda T.　 J Endocr Soc　2　2　135-139　2017/12/06
  • 　Genistein and menaquinone-4 treatment-induced alterations in the expression of mRNAs and their products are beneficial to osteoblastic MC3T3-E1 cell functions.　Katsuyama M, Demura M, Katsuyama H, Tanii H, Saijoh K.　Mol Med Rep.　16　1　873-880　2017/07
  • 　Association between posttraumatic stress disorder (PTSD) severity and ego structure of the Nanai people　Ota Y, Korshunova N, Demura M, Katsuyama M, Katsuyama H, Rahayu SR, Saijoh K　ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE　22　1　1-8　2017/12
  • 　Cortisol overproduction results from DNA methylation of CYP11B1 in hypercortisolemia.　Kometani M, Yoneda T, Demura M, Koide H, Nishimoto K, Mukai K, Gomez-Sanchez CE, Akagi T, Yokota T, Horike SI, Karashima S, Miyamori I, Yamagishi M, Takeda Y.　Sci Rep.　7　1　11205　2017/09
  • 　The Long-term Effect of Adrenal Arterial Embolization for Unilateral Primary Aldosteronism on Cardiorenovascular Protection, Blood Pressure, and the Endocrinological Profile. 　Kometani M, Yoneda T, Demura M, Karashima S, Mori S, Oe M, Sawamura T, Okuda R, Yamagishi M, Takeda Y. 　Intern Med　55　769-773　2016
  • 　Impact of New Quick Gold Nanoparticle-Based Cortisol Assay During Adrenal Vein Sampling for Primary Aldosteronism. 　 Yoneda T, Karashima S, Kometani M, Usukura M, Demura M, Sanada J, Minami T, Koda W, Gabata T, Matsui O, Idegami K, Takamura Y, Tamiya E, Oe M, Nakai M, Mori S, Terayama N, Matsuda Y, Kamemura K, Fujii S, Seta T, Sawamura T, Okuda R, Takeda Y, Hayashi K, Yamagishi M, Takeda Y. 　J Clin Endocrinol Metab　101　2254-2261　2016
  • 　Dynamic CCAAT/enhancer binding protein-associated changes of DNA methylation in the angiotensinogen gene. 　Wang F, ✔Demura M, Cheng Y, Zhu A, Karashima S, Yoneda T, Demura Y, Maeda Y, Namiki M, Ono K, Nakamura Y, Sasano H, Akagi T, Yamagishi M, Saijoh K, Takeda Y. 　Hypertension　63　281-288　2014
  • 　Multiple noncoding exons 1 of nuclear receptors NR4A family (nerve growth factor-induced clone B, Nur-related factor 1 and neuron-derived orphan receptor 1) and NR5A1 (steroidogenic factor 1) in human cardiovascular and adrenal tissues　Journal of Hypertension　29　6　1185-1195　2011/06/01　

Conference Presentations

  • miRNA-mediated crosstalk between Wnt3a and TGF beta 3 in osteoblast differentiation(conference：FASEB JOURNAL)(2017/04)
  • Immunohistochemical Analysis of Adrenal Subclinical Cushing's Syndrome with Aldosterone Excess(2017/10/20)
  • Epigenetic Regulation of Aldosterone Synthase Gene by Potassium(conference：ENDO 2019)(2019/03/24)

Others

  • 　The role of DNA methylation on Hypertension　Masashi Demura　86　2　199　2020/05/10
  • 　Epigenetics of aldosterone synthase gene　Yoshimichi Takeda, Masashi Demura, Yoshiyu Takeda　CARDIOANGIOLOGY　86　2　199　2019/08/28
  • 　Dynamic CCAAT/enhancer binding protein-associated changes of DNA methylation in the angiotensinogen gene.　Wang F, Demura M, Cheng Y, Zhu A, Karashima S, Yoneda T, Demura Y, Maeda Y, Namiki M, Ono K, Nakamura Y, Sasano H, Akagi T, Yamagishi M, Saijoh K, Takeda Y.　World Biomedical Frontiers　2015 Hypertension　2015
  • 　Dynamic regulation of the angiotensinogen gene by DNA methylation, which is influe nced by various stimuli experienced in daily life.　Demura M, Demura Y, Takeda Y, Saijoh K.　Hypertens Res.　38　8　519-527　2015
  • 　Epigenetics in aldosterone production　65　10　2253-2260　2010/10

Arts and Fieldwork

Patent

Theme to the desired joint research

○Molecular mechanisms for aldosterone production and effect of aldosterone on target organs

Grant-in-Aid for Scientific Research

○「自己免疫性原発性アルドステロン症の確立と自己抗体測定法の開発」(2017-2019)　
○「心血管アルドステロンの合成制御機構の解明」(2009-2011)　

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Hygiene(2019)
○Medical Ethics(2019)
○Medical Ethics(2018)
○Medical Ethics(2017)
○Medical Ethics(2017)
○Medical Ethics(2016)

Classes (Graduate Schools)

○Environment and Health(2019)
○Environmental and Molecular Bio-Informatics(2019)
○Bio-Ethics(2019)
○Bio-Ethics(2019)
○Environmental and Molecular Bio-Informatics(2019)
○Environmental and Molecular Bio-Informatics(2018)
○Bio-Ethics(2018)
○Bio-Ethics(2017)
○Environmental and Molecular Bio-Informatics(2017)
○Environmental and Molecular Bio-Informatics(2017)
○Bio-Ethics･Research-Ethics(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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