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Researcher Information

last modified：2024/11/22

Assistant Professor　NAGASHIMADA, Mayumi

Faculty, Affiliation

Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field

Division of Health Sciences, Graduate School of Medical Science
Department of Laboratory Sciences，School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Academic Background

Career

Year & Month of Birth

Academic Society



JAPAN SOCIETY FOR THE STUDY OF OBESITY
THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

Award

Specialities

Speciality Keywords

Research Themes

Books

Papers

  • 　CX3CL1/CX3CR1 interaction protects against lipotoxicity-induced nonalcoholic steatohepatitis by regulating macrophage migration and M1/M2 status.　Yinhua Ni,Fen Zhuge,Liyang Ni,Naoto Nagata,Tatsuya Yamashita,Naofumi Mukaida,Shuichi Kaneko,Tsuguhito Ota,Mayumi Nagashimada　Metabolism: clinical and experimental　136　155272　2022/07/29
  • 　CC chemokine ligand 3 deficiency ameliorates diet-induced steatohepatitis by regulating liver macrophage recruitment and M1/M2 status in mice.　Liang Xu,Yongping Chen,Mayumi Nagashimada,Yinhua Ni,Fen Zhuge,Guanliang Chen,Haoran Li,Tongtong Pan,Tatsuya Yamashita,Naofumi Mukaida,Shuichi Kaneko,Tsuguhito Ota,Naoto Nagata　Metabolism: clinical and experimental　125　154914　2021/12
  • 　LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH.　Noboru Takata,Kiyo-Aki Ishii,Hiroaki Takayama,Mayumi Nagashimada,Kyoko Kamoshita,Takeo Tanaka,Akihiro Kikuchi,Yumie Takeshita,Yukako Matsumoto,Tsuguhito Ota,Yasuhiko Yamamoto,Satoshi Yamagoe,Akihiro Seki,Yoshio Sakai,Shuichi Kaneko,Toshinari Takamura　Scientific reports　11　1　555　2021/01/12
  • 　Enhanced enteric neurogenesis by Schwann cell precursors in mouse models of Hirschsprung disease.　Toshihiro Uesaka,Mitsumasa Okamoto,Mayumi Nagashimada,Yoshihiro Tsuda,Miho Kihara,Hiroshi Kiyonari,Hideki Enomoto　Glia　69　11　2575　2021/11
  • 　Effect of Microbiome on Non-Alcoholic Fatty Liver Disease and the Role of Probiotics, Prebiotics, and Biogenics.　Mayumi Nagashimada,Masao Honda　International journal of molecular sciences　22　15　2021/07/27

show all

  • 　CX3CL1-CX3CR1 Signaling Deficiency Exacerbates Obesity-induced Inflammation and Insulin Resistance in Male Mice.　Mayumi Nagashimada,Kazuki Sawamoto,Yinhua Ni,Hironori Kitade,Naoto Nagata,Liang Xu,Masuko Kobori,Naofumi Mukaida,Tatsuya Yamashita,Shuichi Kaneko,Tsuguhito Ota　Endocrinology　162　6　2021/06/01
  • 　Lactobacillus pentosus strain S-PT84 improves steatohepatitis by maintaining gut permeability.　Yuriko Sakai,Hideyuki Arie,Yinhua Ni,Fen Zhuge,Liang Xu,Guanliang Chen,Naoto Nagata,Takuya Suzuki,Shuichi Kaneko,Tsuguhito Ota,Mayumi Nagashimada　The Journal of endocrinology　247　2　169　2020/11
  • 　Xanthine oxidase inhibition attenuates insulin resistance and diet-induced steatohepatitis in mice.　Tomoki Nishikawa,Naoto Nagata,Tetsuro Shimakami,Takashi Shirakura,Chieko Matsui,Yinhua Ni,Fen Zhuge,Liang Xu,Guanliang Chen,Mayumi Nagashimada,Taro Yamashita,Yoshio Sakai,Tatsuya Yamashita,Eishiro Mizukoshi,Masao Honda,Shuichi Kaneko,Tsuguhito Ota　Scientific reports　10　1　815　2020/01/21
  • 　DPP-4 Inhibition with Anagliptin Reduces Lipotoxicity-Induced Insulin Resistance and Steatohepatitis in Male Mice.　Yuriko Sakai,Guanliang Chen,Yinhua Ni,Fen Zhuge,Liang Xu,Naoto Nagata,Shuichi Kaneko,Tsuguhito Ota,Mayumi Nagashimada　Endocrinology　161　10　2020/10/01
  • 　Lycopene prevents the progression of lipotoxicity-induced nonalcoholic steatohepatitis by decreasing oxidative stress in mice.　Yinhua Ni,Fen Zhuge,Mayumi Nagashimada,Naoto Nagata,Liang Xu,Sayo Yamamoto,Nobuo Fuke,Yusuke Ushida,Hiroyuki Suganuma,Shuichi Kaneko,Tsuguhito Ota　Free radical biology & medicine　2019/11/29
  • 　Lycopene Alleviates Obesity-Induced Inflammation and Insulin Resistance by Regulating M1/M2 Status of Macrophages.　Guanliang Chen,Yinhua Ni,Naoto Nagata,Fen Zhuge,Liang Xu,Mayumi Nagashimada,Sayo Yamamoto,Yusuke Ushida,Nobuo Fuke,Hiroyuki Suganuma,Shuichi Kaneko,Tsuguhito Ota　Molecular nutrition & food research　63　21　e1900602　2019/11
  • 　Pirfenidone prevents and reverses hepatic insulin resistance and steatohepatitis by polarizing M2 macrophages.　Guanliang Chen,Yinhua Ni,Naoto Nagata,Liang Xu,Fen Zhuge,Mayumi Nagashimada,Shuichi Kaneko,Tsuguhito Ota　Laboratory investigation; a journal of technical methods and pathology　99　9　1335　2019/09
  • 　Role of vitamin E in nonalcoholic fatty liver disease.　Nagashimada M,Ota T　IUBMB life　71　4　516　2019/04
  • 　Empagliflozin reverses obesity and insulin resistance through fat browning and alternative macrophage activation in mice fed a high-fat diet.　Liang Xu,Naoto Nagata,Guanliang Chen,Mayumi Nagashimada,Fen Zhuge,Yinhua Ni,Yuriko Sakai,Shuichi Kaneko,Tsuguhito Ota　BMJ open diabetes research & care　7　1　e000783　2019
  • 　TAF7 is a heat-inducible unstable protein and is required for sustained expression of heat shock protein genes.　Nagashimada M,Ueda T,Ishita Y,Sakurai H　The FEBS journal　285　17　3215　2018/09
  • 　A porcine placental extract prevents steatohepatitis by suppressing activation of macrophages and stellate cells in mice.　Liang Xu,Naoto Nagata,Mayumi Nagashimada,Fen Zhuge,Yinhua Ni,Guanliang Chen,Junzo Kamei,Hiroki Ishikawa,Yasuhiko Komatsu,Shuichi Kaneko,Tsuguhito Ota　Oncotarget　9　19　15047　2018/03/13
  • 　SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice.　Liang Xu,Naoto Nagata,Mayumi Nagashimada,Fen Zhuge,Yinhua Ni,Guanliang Chen,Eric Mayoux,Shuichi Kaneko,Tsuguhito Ota　EBioMedicine　20　137　2017/06
  • 　Reply to the Letter to the Editor by Li et al.: Bioinformatics Analysis in Mice with Diet-Induced Nonalcoholic Steatohepatitis Treated with Astaxanthin and Vitamin E　Masuko Kobori,Yumiko Takahashi,Mutsumi Sakurai,Yinhua Ni,Guanliang Chen,Mayumi Nagashimada,Shuichi Kaneko,Tsuguhito Ota　INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES　18　5　2017/05
  • 　Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice.　Naoto Nagata,Liang Xu,Susumu Kohno,Yusuke Ushida,Yudai Aoki,Ryohei Umeda,Nobuo Fuke,Fen Zhuge,Yinhua Ni,Mayumi Nagashimada,Chiaki Takahashi,Hiroyuki Suganuma,Shuichi Kaneko,Tsuguhito Ota　Diabetes　66　5　1222　2017/05
  • 　Hepatic Transcriptome Profiles of Mice with Diet-Induced Nonalcoholic Steatohepatitis Treated with Astaxanthin and Vitamin E　Masuko Kobori,Yumiko Takahashi,Mutsumi Sakurai,Yinhua Ni,Guanliang Chen,Mayumi Nagashimada,Shuichi Kaneko,Tsuguhito Ota　INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES　18　3　2017/03
  • 　DPP-4 Inhibition by Linagliptin Attenuates Obesity-Related Inflammation and Insulin Resistance by Regulating M1/M2 Macrophage Polarization　Fen Zhuge,Yinhua Ni,Mayumi Nagashimada,Naoto Nagata,Liang Xu,Naofumi Mukaida,Shuichi Kaneko,Tsuguhito Ota　DIABETES　65　10　2966　2016/10
  • 　DPP-4 inhibition by linagliptin attenuates obesity-related inflammation and insulin resistance by regulating M1/M2 macrophage polarization.　Zhuge F,Ni Y,Nagashimada M,Nagata N,Xu L,Mukaida N,Kaneko S,Ota T　Diabetes　65　10　2966　2016/07
  • 　Novel Action of Carotenoids on Non-Alcoholic Fatty Liver Disease: Macrophage Polarization and Liver Homeostasis　Yinhua Ni,Fen Zhuge,Mayumi Nagashimada,Tsuguhito Ota　NUTRIENTS　8　7　2016/07
  • 　Central Insulin Action Activates Kupffer Cells by Suppressing Hepatic Vagal Activation via the Nicotinic Alpha 7 Acetylcholine Receptor　Kumi Kimura,Mamoru Tanida,Naoto Nagata,Yuka Inaba,Hitoshi Watanabe,Mayumi Nagashimada,Tsuguhito Ota,Shun-ichiro Asahara,Yoshiaki Kido,Michihiro Matsumoto,Koji Toshinai,Masamitsu Nakazato,Toshishige Shibamoto,Shuichi Kaneko,Masato Kasuga,Hiroshi Inoue　CELL REPORTS　14　10　2362　2016/03
  • 　Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E　Yinhua Ni,Mayumi Nagashimada,Fen Zhuge,Lili Zhan,Naoto Nagata,Akemi Tsutsui,Yasuni Nakanuma,Shuichi Kaneko,Tsuguhito Ota　SCIENTIFIC REPORTS　5　17192　2015/11
  • 　Neuronal Differentiation in Schwann Cell Lineage Underlies Postnatal Neurogenesis in the Enteric Nervous System　Toshihiro Uesaka,Mayumi Nagashimada,Hideki Enomoto　JOURNAL OF NEUROSCIENCE　35　27　9879　2015/07
  • 　Prevention and Reversal of Lipotoxicity-Induced Hepatic Insulin Resistance and Steatohepatitis in Mice by an Antioxidant Carotenoid, beta-Cryptoxanthin　Yinhua Ni,Mayumi Nagashimada,Lili Zhan,Naoto Nagata,Masuko Kobori,Minoru Sugiura,Kazunori Ogawa,Shuichi Kaneko,Tsuguhito Ota　ENDOCRINOLOGY　156　3　987　2015/03
  • 　Prevention and reversal of lipotoxicity-induced nonalcoholic steatohepatitis by an antioxidant carotenoid, β-cryptoxanthin.　Ni Y,Nagashimada M,Zhan L,Nagata N,Kobori M,Sugiura M,Ogawa K,Kaneko S,Ota T　135　1　67　2015
  • 　beta-Cryptoxanthin Alleviates Diet-Induced Nonalcoholic Steatohepatitis by Suppressing Inflammatory Gene Expression in Mice　Masuko Kobori,Yinhua Ni,Yumiko Takahashi,Natsumi Watanabe,Minoru Sugiura,Kazunori Ogawa,Mayumi Nagashimada,Shuichi Kaneko,Shigehiro Naito,Tsuguhito Ota　PLOS ONE　9　5　e98294　2014/05
  • 　GDNF Signaling Levels Control Migration and Neuronal Differentiation of Enteric Ganglion Precursors　Toshihiro Uesaka,Mayumi Nagashimada,Hideki Enomoto　JOURNAL OF NEUROSCIENCE　33　41　16372　2013/10
  • 　Autonomic neurocristopathy-associated mutations in PHOX2B dysregulate Sox10 expression　Mayumi Nagashimada,Hiroshi Ohta,Chong Li,Kazuki Nakao,Toshihiro Uesaka,Jean-Francois Brunet,Jeanne Amiel,Delphine Trochet,Teruhiko Wakayama,Hideki Enomoto　JOURNAL OF CLINICAL INVESTIGATION　122　9　3145　2012/09
  • 　CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status　Hironori Kitade,Kazuki Sawamoto,Mayumi Nagashimada,Hiroshi Inoue,Yasuhiko Yamamoto,Yoshimichi Sai,Toshinari Takamura,Hiroshi Yamamoto,Ken-ichi Miyamoto,Henry N. Ginsberg,Naofumi Mukaida,Shuichi Kaneko,Tsuguhito Ota　DIABETES　61　7　1680　2012/07
  • 　Diminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in mice.　Uesaka T,Nagashimada M,Yonemura S,Enomoto H　The Journal of clinical investigation　118　5　1890　2008/05
  • 　Differential gene expression and functional analysis implicate novel mechanisms in enteric nervous system precursor migration and neuritogenesis　Bhupinder P. S. Vohra,Keiji Tsuji,Mayumi Nagashimada,Toshihiro Uesaka,Daniel Wind,Ming Fu,Jennifer Armon,Hideki Enomoto,Robert O. Heuckeroth　DEVELOPMENTAL BIOLOGY　298　1　259　2006/10

Conference Presentations

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「運動と非アルコール性脂肪肝炎の改善をつなぐ制御分子機構の解明」(2022-2026)　
○「マクロファージ極性をM2へと導く新規転写因子の機能解明と生活習慣病創薬への展開」(2019-2021)　
○「自然発症メタボリック症候群モデルを用いたカロテノイドの新たな生体調節機能の解明」(2015-2018)　
○「インスリン抵抗性の制御におけるフラクタルカインと受容体の役割 」(2013-2015)　

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Lecture on Clinical Laboratory Management(2023)
○Clinical Chemistry Laboratory(2023)
○Experimental Course in Physiology(2023)
○Clinical Chemistry Laboratory(2023)
○Experimental Course in Physiology(2023)
○Introduction to Region-studies(2017)

Classes (Graduate Schools)

International Project

International Students

Lecture themes

Others (Social Activities)

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