last modified：2024/11/22
Professor ANDO Hitoshi
Faculty, Affiliation
Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences Department of Cellular and Molecular Function Analysis
Professor
College and School Educational Field
Division of Medical Sciences, Graduate School of Medical Science
Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
Laboratory
Department of Cellular and Molecular Function Analysis
Academic Background
【Degree】
MD
Career
Kanazawa University(2007/04-2008/02)
Jichi Medical University(2008/03-2009/01)
Jichi Medical University(2009/02-2016/03)
Year & Month of Birth
1969/12
Academic Society
Award
○Grand prize(2011)
○Young Researcher's Award(2011)
○Japan Research Foundation for Clinical Pharmacology Young Researcher's Award(2013)
Specialities
Applied pharmacology
Speciality Keywords
Research Themes
Elucidation of the mechanisms underlying the association between impaired circadian clock and the development of lifestyle-related diseases, and the development of therapeutic agents
Books
Papers
- Brown adipocyte-specific knockout of Bmal1 causes mild but significant impairment of thermogenesis in mice. Nazmul Hasan,Naoto Nagata,Jun-Ichi Morishige,Md Tarikul Islam,Zheng Jing,Ken-Ichi Harada,Mieda Michihiro,Masanori Ono,Hiroshi Fujiwara,Takiko Daikoku,Tomoko Fujiwara,Yoshiko Maida,Tsuguhito Ota,Shigeki Shimba,Shuichi Kaneko,Akio Fujimura,Hitoshi Ando Molecular metabolism 49 101202 2021/03/03
- Time-Restricted Feeding Regulates Circadian Rhythm of Murine Uterine Clock. Hosono T, Ono M, Daikoku T, Mieda M, Nomura S, Kagami K, Iizuka T, Nakata R, Fujiwara T, Fujiwara H, Ando H. Curr Dev Nutr 5 5 nzab064 2021
- Edoxaban Dosing Time Affects Blood Coagulation Inhibition in Rats Nagata N, Kawasumi M, Fujimura A, Ando H. TH Open 5 2 e107-e112 2021
- Serum concentration of the CKD4/6 inhibitor abemaciclib, but not of creatinine, strongly predicts hematological adverse events in patients with breast cancer: a preliminary report. Akimitsu Maeda,Kei Irie,Naoya Hashimoto,Shoji Fukushima,Hitoshi Ando,Akira Okada,Hiromichi Ebi,Masaki Kajita,Hiroji Iwata,Masataka Sawaki Investigational new drugs 39 1 272 2021/02
- Carnitine insufficiency is associated with fatigue during lenvatinib treatment in patients with hepatocellular carcinoma. Okubo H, Ando H, Ishizuka K, Kitagawa R, Okubo S, Saito H, Kokubu S, Miyazaki A, Ikejima K, Shiina S, Nagahara A. PLoS One 15 3 e0229772 2020/03/03
- Social participation and physical prefrailty in older Japanese adults: The Shimane CoHRE study. Takafumi Abe,Kenta Okuyama,Masamitsu Kamada,Shozo Yano,Yuta Toyama,Minoru Isomura,Toru Nabika,Naoki Sakane,Hitoshi Ando,Ryo Miyazaki PloS one 15 12 e0243548 2020
- Adolescent Dietary Habit-induced Obstetric and Gynecologic Disease (ADHOGD) as a New Hypothesis-Possible Involvement of Clock System. Tomoko Fujiwara,Masanori Ono,Michihiro Mieda,Hiroaki Yoshikawa,Rieko Nakata,Takiko Daikoku,Naomi Sekizuka-Kagami,Yoshiko Maida,Hitoshi Ando,Hiroshi Fujiwara Nutrients 12 5 2020/05/02
- Induction of Dbp by a histone deacetylase inhibitor is involved in amelioration of insulin sensityvity via adipocyte differentiation in ob/ob mice. Suzuki C, Ushijima K, Ando H, Kitamura H, Horiguchi M, Akita T, Yamashita C, Fujimura A Chronobiol Int 36 955-968 2019/07/01
- Influence of renal ischaemia-reperfusion injury on renal neutrophil gelatinase-associated lipocalin receptor (24p3R) in rats. Arakawa Y, Ushijima K, Tsuchiya H, Morishige JI, Mii A, Ando H, Tsuruoka SI, Fujimura A. Clin Exp Pharmacol Physiol 46 12 1166-1173 2019/12/01
- Plasma concentration and efficacy of tolvaptan in cirrhotic patients with refractory ascites. Sagawa E, Okubo H, Ando H, Sorin Y, Kanazawa R, Nakadera E, Fukada H, Kokubu S, Miyazaki A. J Pharmacol Sci 2019/02/27
- Associations among regorafenib concentrations, severe adverse reactions, and ABCG2 and OATP1B1 polymorphisms. Maeda A, Irie K, Ando H, Hasegawa A, Taniguchi H, Kadowaki S, Muro K, Tajika M, Aoki M, Inaguma K, Kajita M, Fujimura A, Fukushima S. Cancer Chemother Pharmacol 83 107-113 2019/01/01
- Plasma concentration and efficacy of tolvaptan in cirrhotic patients with refractory ascites. Sagawa E,Okubo H,Ando H,Sorin Y,Kanazawa R,Nakadera E,Fukada H,Kokubu S,Miyazaki A J Pharmacol Sci 139 4 373 2019
- Associations among regorafenib concentrations, severe adverse reactions, and ABCG2 and OATP1B1 polymorphisms. Maeda A,Irie K,Ando H,Hasegawa A,Taniguchi H,Kadowaki S,Muro K,Tajika M,Aoki M,Inaguma K,Kajita M,Fujimura A,Fukushima S Cancer Chemother Pharmacol 83 1 107 2019
- Time restriction of food intake during the circadian cycle Is a possible reegulator of reproductive function in postadolescent female rats. Fujiwara T, Nakata R, Ono M, Mieda M, Ando H, Daikoku T, Fujiwara H. Curr Dev Nutr 3 4 nzy093 2018/11/26
- Development and initial validation of the Morningness-Eveningness Exercise Preference Questionnaire (MEEPQ) in Japanese university students. Miyazaki R, Ando H, Hamasaki T, Higuchi Y, Oshita K, Tashiro T, Sakane N. PLoS One 13 e0200870 2018/07/18
- Pulmonary administration of curcumin inhibits B16F10 melanoma lung metastasis and invasion in mice. Shimada K, Ushijima K, Suzuki C, Horiguchi M, Ando H, Akita T, Shimamura M, Fujii J, Yamashita C, Fujimura A. Cancer Chemother Pharmacol 82 265-273 2018/06/04
- Chronotherapy of maxacalcitol on skin inflammation induced by topical 12-O-tetradecanoylphorbol-13-acetate in mice. Yoshioka D, Ando H, Ushijima K, Kumazaki M, Fujimura A. Chronobiol Int 35 9 1269-1280 2018/05/18
- Gadoxetic acid-enhanced magnetic resonance imaging to predict paritaprevir-induced hyperbilirubinemia during treatment of hepatitis C. Okubo H, Ando H, Sorin Y, Nakadera E, Fukada H, Morishige J, Miyazaki A, Ikejima K. PLoS One 13 e0196747 2018/04/30
- Influence of a dosing-time on toxicities induced by docetaxel, cisplatin and 5-fluorouracil in patients with oral squamous cell carcinoma; a cross-over pilot study. Tsuchiya Y, Ushijima K, Noguchi T, Okada N, Hayasaka JI, Jinbu Y, Ando H, Mori Y, Kusama M, Fujimura A. Chronobiol Int 35 289-294 2018/02/01
- Differences in urinary renal failure biomarkers in cancer patients initially treated with cisplatin. Maeda A, Ando H, Ura T, Muro K, Aoki M, Saito K, Kondo E, Takahashi S, Ito Y, Mizuno Y, Fujimura A. Anticancer Res 37 5235-5239 2017/09/01
- Dosing-time-dependent effect of rivaroxaban on coagulation activity in rats. Fujiwara Y, Ando H, Ushijima K, Horiguchi M, Yamashita C, Fujimura A. J Pharmacol Sci 134 234-238 2017/08/12
- Prevention against renal damage in rats with subtotal nephrectomy by sacubitril/valsartan (LCZ696), a dual-acting angiotensin receptor-neprilysin inhibitor. Ushijima K, Ando H, Arakawa Y, Aizawa K, Suzuki C, Shimada K, Tsuruoka SI, Fujimura A. Pharmacol Res Perspect 5 e00336 2017/08/01
- Association between ABCG2 and SLCO1B1 polymorphisms and adverse drug reactions to regorafenib: a preliminary study. Maeda A, Ando H, Ura T, Komori A, Hasegawa A, Taniguchi H, Kadowaki S, Muro K, Tajika M, Kobara M, Matsuzaki M, Hashimoto N, Maeda M, Kojima Y, Aoki M, Kondo E, Mizutani A, Fujimura A. Int J Clin Pharmacol Ther 55 409-415 2017/05/01
- Effect of a dosing-time on quetiapine-induced acute hyperglycemia in mice. Kapse S, Ando H, Fujiwara Y, Suzuki C, Ushijima K, Kitamura H, Hosohata K, Kotani K, Shimba S, Fujimura A. J Pharmacol Sci 133 139-145 2017/02/17
- The Effect of Treatments for Rheumatoid Arthritis on Endothelial Dysfunction Evaluated by Flow-Mediated Vasodilation in Patients with Rheumatoid Arthritis. Kotani K, Miyamoto M, Ando H. Curr Vasc Pharmacol 15 1 10-18 2017/01/01
- Gadoxetic Acid-Enhanced MR Imaging Predicts Simeprevir-Induced Hyperbilirubinemia During Hepatitis C Virus Treatment: A Pilot Study. Okubo H, Kitamura T, Ando H, Fukada H, Igusa Y, Kokubu S, Miyazaki A, Fujimura A, Shiina S, Watanabe S. J Clin Pharmacol 57 369-375 2016/09/22
- Early prediction of cisplatin-induced nephrotoxicity by urinary vanin-1 in patients with urothelial carcinoma. Hosohata K, Washino S, Kubo T, Natsui S, Fujisaki A, Kurokawa S, Ando H, Fujimura A, Morita T. Toxicology 359-360 71-75 2016/06/01
- Influence of genetic polymorphisms of multidrug and toxin extrusion protein 1 on its mRNA expression in peripheral blood cells. Ando H, Nakano K, Ushijima K, Kurokawa S, Washino S, Hosohata K, Morita T, Fujimura A. J Pharmacol Sci 131 2 138-140 2016/06/01
- Daily Fasting Blood Glucose Rhythm in Male Mice: A Role of the Circadian Clock in the Liver. Ando H, Ushijima K, Shimba S, Fujimura A. Endocrinology 157 2 463-469 2016/02/01
- Early urinary biomarkers for renal tubular damage in spontaneously hypertensive rats on a high salt intake. Hosohata K, Yoshioka D, Tanaka A, Ando H, Fujimura A. Hypertens Res 39 1 19-26 2016/01/01
- Radiofrequency ablation combined with chemolipiodolization in a porcine liver: Comparison of the pharmacokinetic analysis with cisplatin powder and miriplatin Tomoyasu Ito,Hironao Okubo,Shigehiro Kokubu,Akihisa Miyazaki,Hitoshi Ando,Akio Fujimura,Sumio Watanabe HEPATOLOGY RESEARCH 45 5 589 2015/05
- Different chronotherapeutic effects of valsartan and olmesartan in non-dipper hypertensive patients during valsartan treatment at morning Kentaro Ushijima,Hajime Nakashima,Tsuyoshi Shiga,Kazuhiro Harada,Shizukiyo Ishikawa,Takashi Ioka,Hitoshi Ando,Akio Fujimura JOURNAL OF PHARMACOLOGICAL SCIENCES 127 1 62 2015/01
Conference Presentations
- Disruption of circadian clocks and metabolic diseases(conference：The 1st Tufts University-Kanazawa University Joint Symposium)(2016/12/13)
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「末梢体内時計障害の本態の解明と治療基盤の確立」(2021-2023)
○「思春期の欠食とダイエットで性差をもって“リプログラミング”される食欲と代謝効率」(2021-2024)
○2023「概日リズムに基づく妊娠・産褥期セルフケアプログラムの開発-光と食による制御の検討」(2020-2023)
○2021「がん自然発症マウスを用いた末梢概日リズム異常によるがん発生・進展誘導機構の解析」(2020-2021)
○「摂食リズムの非同期による時計遺伝子の記憶が誘発する女性生殖機能異常の総合的解析」(2019-2021)
○「概日リズムによる子宮収縮制御機構に着目した産婦人科疾患予防法の探索」(2019-2021)
○「褐色脂肪細胞における熱産生リズムの形成機構解明と制御法の開発」(2018-2020)
○「末梢体内時計障害の病態生理学的意義の解明と治療法の開発」(2015-2017)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Pharmacology(2021)
Classes (Graduate Schools)
○Medical Sciences(2021)
○Molecular Function Analysis(2021)
○Introduction to Basic Medical Science(2021)
○Bio-Ethics(2021)
○Intensive Lectures on Medical Researches(2021)
○Basic Training on Medical Researches(2021)