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Researcher Information

last modified：2024/01/08

Associate Professor　KITAMURA Yoji

Mail

Faculty, Affiliation

Research Center for Experimental Modeling of Human Disease

College and School Educational Field

Division of Natural System, Graduate School of Natural Science and Technology

Laboratory

Division of Tracer Kinetics, Advanced Science Research Center　TEL:076-265-2474　FAX:076-234-4245

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kyoto University　Doctor　200303　Unfinished course
Kyoto University　Master　200103　Completed
【Academic background(Bachelor's Degree)】
Kyoto University　199903
【Degree】
PH.D.

Career

Kanazawa University　Advanced Science Research Center(2009/10/01-)
Okayama University(2007/04/01-2009/09/30)
Okayama University(2005/04/01-2007/04/01)
Okayama University(2004/06/15-2005/04/01)
Kobe Gakuin University(2003/04/01-2004/06/14)

Year & Month of Birth

1976/01

Academic Society

The Pharmaceutical Society of Japan
THE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Japanese Society for Molecular Imaging
Japanese Cancer Association
Japanese Society of Radiation Safety Management

The Japan Society for Analytical Chemistry
Japan Society for Biomedical Research on Trace Elements
Japanese Society for Food Hygiene and Safety

Award

Japanese Society for Food Hygiene and Safety

Specialities

Speciality Keywords

Research Themes

Books

Papers

  • 　Redesign of negatively charged 111In-DTPA-octreotide derivative to reduce renal radioactivity　Oshima N., Akizawa H., Kawashima H., Zhao S., Zhao Y., Nishijima K. I., Kitamura Y., Arano Y., Kuge Y. and Ohkura K.　Nuclear medicine and biology　48　16　2017/02/06
  • 　Evaluation of Ga-DOTA-(D-Asp)n as bone imaging agents: D-aspartic acid peptides as carriers to bone　Ogawa K., Ishizaki A., Takai K., Kitamura Y., Makino A., Kozaka T., Kiyono Y., Shiba K. and Odani A.　Scientific Reports　7　1　13971　2017/10/25
  • 　Synthesis and evaluation of radioiodinated 1-{2-[5-(2-methoxyethoxy)-1H-benzo[d]imidazol-1-yl]quinolin-8-yl}piperidin-4-amine derivatives for platelet-derived growth factor receptor β (PDGFRβ) imaging.　Effendi N., Ogawa K., Mishiro K., Takarada T., Yamada D., Kitamura Y., Shiba K., Maeda T. and Odani A.　Bioorganic & Medicinal Chemistry　25　20　5576-5585　2017/10/15
  • 　Redesign of negatively charged 111In-DTPA-octreotide derivative to reduce renal radioactivity　Nobuhiro Oshima, Hiromichi Akizawa, Hidekazu Kawashima, Songji Zhao, Yan Zhao, Ken-ichi Nishijima, Yoji Kitamura, Yasushi Arano, Yuji Kuge, Kazue Ohkura　Nuclear Medicine and Biology　48　16-25　2017/02/06
  • 　In Vivo Differences between Two Optical Isomers of Radioiodinated o-iodo-trans-decalinvesamicol for Use as a Radioligand for the Vesicular Acetylcholine Transporter　Uno I., Kozaka T., Miwa D., Kitamura Y., Azim M. A.-u., Ogawa K., Taki J., Kinuya S. and Shiba K.　PLoS ONE　11　1　e0146719　2016/01/11

show all

  • 　Evaluation of Chlorella as a Decorporation Agent to Enhance the Elimination of Radioactive Strontium from Body　Ogawa K., Fukuda T., Han J., Kitamura Y., Shiba K. and Odani A.　Plos One　11　2　2016/02/01
  • 　The potential of o-bromo-trans-decalinvesamicol as a new PET ligand for vesicular acetylcholine transporter imaging　Azim M. A.-u., Kozaka T., Uno I., Miwa D., Kitamura Y., Ogawa K., Makino A., Kiyono Y. and Shiba K.　Synapse　68　10　445-453　2014/08　
  • 　Synthesis and evaluation of a new vesamicol analog o-[11C]methyl-trans-decalinvesamicol as a PET ligand for the vesicular acetylcholine transporter　Kitamura Y., Kozaka T., Miwa D., Uno I., Azim M. A.-u., Ogawa K., Taki J., Kinuya S. and Shiba K.　Annals of Nuclear Medicine　30　2　122-129　2015/11/25
  • 　Radiogallium Complex-Conjugated Bifunctional Peptides for Detecting Primary Cancer and Bone Metastases Simultaneously　Ogawa K., Yu J., Ishizaki A., Yokokawa M., Kitamura M., Kitamura Y., Shiba K. and Odani A　Bioconjugate Chemistry　26　8　1561-1570　2015/08/19
  • 　Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease　Lopatina O., Yoshihara T., Nishimura T., Zhong J., Akther S., Fakhrul A. A., Liang M., Higashida C., Sumi K., Furuhara K., Inahata Y., Huang J. J., Koizumi K., Yokoyama S., Tsuji T., Petugina Y., Sumarokov A., Salmina A. B., Hashida K., Kitao Y., Hori O., Asano M., Kitamura Y., Kozaka T., Shiba K., Zhong F., Xie M. J., Sato M., Ishihara K. and Higashida H.　Front Behav Neurosci　8　133　2014/04/22
  • 　Regional brain imaging of vesicular acetylcholine transporter using o-[125I]iodo-trans-decalinvesamicol as a new potential imaging probe　Kozaka T., Uno I., Kitamura Y., Miwa D., Anwar-Ul Azim M., Ogawa K. and Shiba K.　Synapse　68　3/7　107-113　2014
  • 　Design, synthesis and biological evaluation of negatively charged 111In-DTPA-octreotide derivatives　Oshima N., Akizawa H., Zhao S., Zhao Y., Nishijima K., Kitamura Y., Arano Y., Kuge Y. and Ohkura K.　Bioorg Med Chem　22　4　1377-82　2014/02/15
  • 　Development of Novel Radiogallium-Labeled Bone Imaging Agents Using Oligo-Aspartic Acid Peptides as Carriers　PLoS ONE　8　12　e84335　2013/12/31
  • 　Development and Evaluation of a Novel 99mTc-Labeled Annexin A5 for Early Detection of Response to Chemotherapy　Ogawa K., Ohtsuki K., Shibata T., Aoki M., Nakayama M., Kitamura Y., Ono M., Ueda M., Doue T., Onoguchi M., Shiba K. and Odani A.　PLoS ONE　8　12　e81191　2013/12/04
  • 　Decontamination of radioactivity from contaminated vegetables derived from the Fukushima nuclear accident　RADIATION MEASUREMENTS　55　26-29　2013/08
  • 　Development of new zinc dithiosemicarbazone complex for use as oral antidiabetic agent.　BIOLOGICAL TRACE ELEMENT RESEARCH　154　1　111-119　2013/07
  • 　Development and evaluation of a radiobromine-labeled sigma ligand for tumor imaging.　NUCLEAR MEDICINE AND BIOLOGY　40　4　445-450　2013/05
  • 　Development and evaluation of a novel radioiodinated vesamicol analog as a sigma receptor imaging agent　EJNMMI Research　2　1　54　2012/12
  • 　Characteristics of radioactive contamination of vegetables derived from the Fukushima nuclear accident.　Radiation Safety Management　11　1　23-26　2012/12
  • 　Chemical removal of radionuclides in contaminated spinach derived from the Fukushima nuclear accident　Radiation Safety Management　11　1　in press　2012/12
  • 　Syntheses and in vitro evaluation of decalinvesamicol analogues as potential imaging probes for vesicular acetylcholine transporter (VAChT)　BIOORGANIC & MEDICINAL CHEMISTRY　20　16　4936-4941　2012/07
  • 　Endogenous Secretory Receptor for Advanced Glycation End-Products Inhibits Amyloid-beta1-42 Uptake into Mouse Brain.　Sugihara T., Munesue S., Yamamoto Y., Sakurai S., Akhter N., Kitamura Y., Shiba K., Watanabe T., Yonekura H., Hayashi Y., Hamada J. and Yamamoto H.　J Alzheimers Dis　28　709-720　2012/01
  • 　Preparation and evaluation of a radiogallium complex-conjugated bisphosphonate as a bone scintigraphy agent.　Ogawa K., Takai K., Kanbara H., Kiwada T., Kitamura Y., Shiba K. and Odani A.　NUCLEAR MEDICINE AND BIOLOGY　38　631-636　2011/01
  • 　5-Iodo-A-85380, a specific ligand for alpha4beta2 nicotinic acetylcholine receptors, prevents glutamate neurotoxicity in rat cortical cultured neurons.　Ueda M., Iida Y., Kitamura Y., Kawashima H., Ogawa M., Magata Y. and Saji H.　BRAIN RESEARCH　1199　46-52　2008/01
  • 　Peroxidase-like catalytic activity of aqueous- and immobilized-Mn3+-octabromo- porphyrins on ion-exchange resin supplied as mimetic of horseradish peroxidase.　Kitamura Y., Mori K., Yamamoto M., Nozaki A., Saito M., Tsukamoto I., Mifune M. and Saito Y.　CHEMICAL & PHARMACEUTICAL BULLETIN　56　1364-1366　2008/01
  • 　Ion-exchange resins modified with metal-porphyrin as a catalysis for oxidation of epinephrine (adrenaline).　Kitamura Y., Mifune M., Takatsuki T., Iwasaki T., Kawamoto M., Iwado A., Chikuma M. and Saito Y.　Catalysis Communications　9　224-228　2008/01
  • 　Catalytic activity of silica gels bound manganese(III)-porphyrin on oxidative reaction of adrenaline.　Kitamura Y., Takatsuki T., Kawamoto M., Saito M., Iwado A., Tsukamoto I., Mifune M. and Saito Y.　CHEMICAL & PHARMACEUTICAL BULLETIN　55　500-502　2007/01
  • 　Chemical Control of Biological Activity and Biodistribution of Metal Compounds: Drug Design of Metal Complexes with Biological Activity and Target-Specific Biodistribution. 　Saji H., Ogawa K., Kitamura Y., Kubota-Akizawa M. and Kawashima H.　Biomed Res Trace Elements　18　255-263　2007/01
  • 　Effect of Carboxyl-Group of D-Glutamic Acid or gamma-Carboxy-D-glutamic Acid as N-Terminal Amino Acid of (111)In-Diethylenetriaminepentaacetic Acid-Octreotide on Accumulation of Radioactivity in Kidney. 　Akizawa H., Saito M., Tsukamoto I., Ohkura T., Shimizu T., Kitamura Y.(Corresponding Authre), Mifune M., Saito Y., Arano Y. and Saji H.　BIOLOGICAL & PHARMACEUTICAL BULLETIN　30　2226-2228　2007/01
  • 　Peroxidase-like catalytic activity of Mn3+-octabromo-tetrakis(4-sulfophenyl)porphine on linoleate hydroperoxide and its analytical application. 　Mifune M., Kamiguchi H., Tai T., Kuremoto S., Yamamoto M., Tsukamoto I., Saito M., Kitamura Y., and Saito Y.　TALANTA　71　456-461　2007/01

Conference Presentations

  • Study on the Application of ATR for the Measurement of Infrared Absorption Spectrum of Food Adductives Identification Tests(2017/03/26)
  • The development of a novel σ-1 receptor imaging agent for SPECT(2017/05/25)
  • The structure-activity relationship between structure of vesamicol analogs and affinity of VAChT and sigma receptors(2017/03/26)
  • The possibility of vesamicol analog with 5-membered ring structure as the sigma-1 receptor imaging agents(2017/03/26)
  • Changes of the dopamine nerve system by stress in the model mouse for 15q duplication.(2017/03/25)

show all

  • Development of a radiobromine-labeled compound as a sigma receptor ligand for tumor imaging.(conference：2016SNMMI 63th annual meeting)(2016/06/12)
  • In vitro evaluation meta-bromo benzovesamicol as PET VAChT imaging Probe.(conference：The 2nd Asian Nuclear Medicine Academic Forum 2016,(ANMAF 2016))(2016/05/06)
  • Bioactive Radionuclear Coordination Compounds(2014/03/28)
  • n vivo evaluation of radiobromine-labeled o-bromo-trans-decalinvesamicol (OBDV) as a potential VAChT imaging probe(2013/12/14)
  • Introduction of radiobromine labeled decalinvesamicol analogue as a new and promising PET vesicular acetylcholine transporter (VAChT) imaging probe(conference：2014 SNMMI 61th annual meeting)(2014/06/08)
  • Evaluation of Radiolabeled o-Bromo-decalinvesamicol (OBDV) as a PET Ligand for the Vesicular Acetylcholine Transporter (VAChT)(conference：International Workshop for Molecular Functional Imaging -Brain and Gynecologic Oncology-(Fukui2014: The Fifth International Workshop on Biomedical Imaging))(2014/03/03)
  • The Process of Radiation Exposure Lymphocyte Damage Assessed by γH2AX Expression Level using Flow Cytometry(conference：2023 13th Congress of the World Federation of Nuclear Medicine and Biology)(2022/09/11)
  • Usefulness of radioiodinated 2-[4-(2-iodophenyl)piperidino] cyclopentanol (OI5V) for early diagnosing neurodegenerative disorder caused by stress. (conference：12th World Congress of the World Federation of Nuclear Medicine and Biology.)(2018/04/22)
  • Characteristics of 2-[4-(2-iodophenyl)piperidino]cyclopenntanon (OI5V) as a new sigma-1 receptor imaging agent.(conference：SNMMI 2017 Annual Meeting)(2017/06/12)

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「食品添加物の安全性確保に資する研究」(2019-2021)　
○「アルツハイマー病の早期診断用シナプス前コリン作動性神経分子イメージング剤の開発」(2014-2017)　
○「腫瘍イメージング剤としての放射性金属－八臭素化ポルフィリンの開発研究」(2015-2017)　
○「食品添加物の安全性確保のための研究」(2016-2018)　
○「腫瘍イメージング剤としての放射性金属－八臭素化ポルフィリンの開発と応用」(2012-2014)
○「食品添加物の規格試験法の向上及び摂取量推定等に関する研究」(2013-2015)　
○「アルツハイマー病の早期診断を目的としたコリントランスポーターイメージング剤の開発」(2011-2013)　
○「腫瘍イメージング剤としての放射性金属-八臭素化ポルフィリンの開発と応用」(2012-2014)　
○「食品添加物の規格の向上と使用実態の把握等に関する研究」(2010-2012)　
○「放射性金属－八臭素化ポルフィリンを用いた新規核医学診断・治療薬剤の開発と応用」(2010-2011)　
○「種々のγ線放出核を用いた早期疾患診断プローブ開発とコンプトンカメラによる複数核種同時イメージング 」(2009-2009)　
○「新規腫瘍放射性医薬品としての放射性金属－八臭素化ポルフィリン錯体の開発」(2008-2009)　
○「国際的動向を踏まえた食品添加物の規格，基準の向上に関する調査研究」(2008-2009)　

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Radioisotope in In-Vitro and In-Vivo Techniques(2017)
○Radiation Protection and Safety Experiment(2017)
○Radiation Protection and Safety Experiment(2016)
○Radioisotope in In-Vitro and In-Vivo Techniques(2016)

Classes (Graduate Schools)

○Introduction to Basic Medical Science(2016)
○Seminar on Advanced Medical Science(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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