last modified：2024/11/22
Professor ONO Kenjiro
Faculty, Affiliation
Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences Department of Neurology
College and School Educational Field
Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
Laboratory
Academic Background
Career
Department of Neurology, Jikei University School of Medicine Department of Neurology Visiting Professor(2023/02/01-)
Department of Neurology, Showa University School of Medicine Department of Neurology Visiting Professor(2021/10/01-)
Keio University School of Medicine Department of Neurology Visiting Professor(2023/04/01-)
Faculty of Medicine, Academic Research Division, University of Toyama Department of Neurology Visiting Professor(2023/04/01-)
Kanazawa Medical University Visiting Professor(2023/04/01-)
Graduate School of Medicine, University of the Ryukyus(2021/04/01-)
Fukuoka University School of Medicine Department of Neurology Visiting Professor(2023/04/01-)
Fujita Medical University Department of Neurology Visiting Professor(2023/04/01-)
Showa Women's University Department of Health Science Visiting Professor(2023/04/01-)
Ishikawa Prefectural Nursing University Visiting Professor(2022/12/16-)
Nagaoka Sutoku University Visiting Professor(2023/04/01-)
Health Science University(2023/04/01-)
Year & Month of Birth
1972/03
Academic Society
Society for Neuroscience
Award
Specialities
Speciality Keywords
Research Themes
Development of preventives and curatives for Alzheimer’s Disease with a focus on organic compounds
Investigation into biomarkers for Alzheimer’s Disease
Development of preventive and therapeutic of Lewy body diseases
Books
- Cerebrospinal fluid and plasma of Alzheimer patients promote beta-amyloid fibril formation in vitro. Boca Raton, Taylor & Francis Group 25-26 2007
Papers
- Anti-fibrillogenic and fibril-destabilizing activity of nicotine in vitro: implications for the prevention and therapeutics of Lewy body diseases. EXPERIMENTAL NEUROLOGY 205 2 414-424 2007/06
- Effects of the English (H6R) and Tottori (D7N) familial Alzheimer disease mutations on amyloid beta-protein assembly and toxicity. Ono K, Condron MM, Teplow DB JOURNAL OF BIOLOGICAL CHEMISTRY 285 30 23186-23197 2010/07
- Anti-fibrillogenic and fibril-destabilizing activities of anti-Parkinsonian agents for alpha-synuclein fibrils in vitro. JOURNAL OF NEUROSCIENCE RESEARCH 85 7 1547-1557 2007/05
- Anti-aggregation and fibril-destabilizing effects of sex hormones on alpha-synuclein fibrils in vitro. Exp Neurol 217 2 434-439 2009/06
- Phenolic compounds prevent Alzheimer's pathology through different effects on the amyloid-beta aggregation pathway. AMERICAN JOURNAL OF PATHOLOGY 175 6 2557-2565 2009/12
- Structure-neurotoxicity relationships of amyloid beta-protein oligomers Ono K, Condron MM, Teplow DB PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME 2009/09
- REVIEW: Curcumin and Alzheimer's disease. 16 5 285-297 2010/10
- Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity. JOURNAL OF BIOLOGICAL CHEMISTRY 283 32176-32187 2008/11
- Epidemiology of familial amyloid polyneuropathy in Japan: Identification of a novel endemic focus. JOURNAL OF THE NEUROLOGICAL SCIENCES 270 1-2 133-140 2008/07
- Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease. JOURNAL OF NEUROSCIENCE 28 25 6388-6392 2008/06
- Cerebrospinal fluid/serum IgG index is correlated with medial temporal lobe atrophy in Alzheimer's disease. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 25 2 144-147 2008/02
- Comparison of 18F-FDG PET and optimized voxel-based morphometry for detection of Alzheimer's disease: aging effect on diagnostic performance. JOURNAL OF NUCLEAR MEDICINE 48 12 1961-1970 2007/12
- Estrogen has anti-amyloidogenic effects on Alzheimer's beta-amyloid fibrils in vitro. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 359 3 697-702 2007/08
- Blood-brain barrier permeability correlates with medial temporal lobe atrophy but not with amyloid-beta protein transport across the blood-brain barrier in Alzheimer's disease. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 23 4 241-245 2007
- The anti-amyloidogenic effect is exerted against Alzheimer's beta-amyloid fibrils in vitro by preferential and reversible binding of flavonoids to the amyloid fibril structure. BIOCHEMISTRY 46 7 1888-1899 2007/02
- Vitamin A potently destabilizes preformed alpha-synuclein fibrils in vitro: implications for Lewy body diseases. Ono K, Yamada M. NEUROBIOLOGY OF DISEASE 25 2 446-454 2007/02
- Cerebrospinal fluid of Alzheimer's disease and dementia with Lewy bodies patients enhances alpha-synuclein fibril formation in vitro. Ono K, Noguchi-Shinohara M, Yoshita M, Naiki H, Yamada M. EXPERIMENTAL NEUROLOGY 203 2 579-583 2007/02
- Blood-borne factors inhibit Alzheimer's beta-amyloid fibril formation in vitro. Ono K, Noguchi-Shinohara M, Samuraki M, Matsumoto Y, Yanase D, Iwasa K, Naiki H, Yamada M. EXPERIMENTAL NEUROLOGY 202 1 125-132 2006/11
- Antioxidant compounds have potent anti-fibrillogenic and fibril-destabilizing effects for alpha-synuclein fibrils in vitro. Ono K, Yamada M. JOURNAL OF NEUROCHEMISTRY 97 1 105-115 2006/04
- Alpha-lipoic acid exhibits anti-amyloidogenicity for beta-amyloid fibrils in vitro. Ono K, Hirohata M, Yamada M. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 341 4 1046-1052 2006/03
- Anti-Parkinsonian agents have anti-amyloidogenic activity for Alzheimer's beta-amyloid fibrils in vitro. Ono K, Hasegawa K, Naiki H, Yamada M. NEUROCHEMISTRY INTERNATIONAL 48 4 275-285 2006/03
- Cerebrospinal fluid of Alzheimer patients promotes beta-amyloid fibril formation in vitro. Ono K, Noguchi M, Matsumoto Y, Yanase D, Iwasa K, Naiki H, Yamada M. NEUROBIOLOGY OF DISEASE 20 2 233-240 2005/11
- Ferulic acid destabilizes preformed beta-amyloid fibrils in vitro. Ono K, Hirohata M, Yamada M. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 336 2 444-449 2005/10
- Non-steroidal anti-inflammatory drugs have anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro. Hirohata M, Ono K, Naiki H, Yamada M. NEUROPHARMACOLOGY 49 7 1088-1099 2005/12
- Decreased beta-amyloid peptide42 in cerebrospinal fluid of patients with progressive supranuclear palsy and corticobasal degeneration. Noguchi M, Yoshita M, Matsumoto Y, Ono K, Iwasa K, Yamada M. JOURNAL OF THE NEUROLOGICAL SCIENCES 237 1-2 61-65 2005/10
- Vitamin A exhibits potent antiamyloidogenic and fibril-destabilizing effects in vitro. Ono K, Yoshiike Y, Takashima A, Hasegawa K, Naiki H, Yamada M. EXPERIMENTAL NEUROLOGY 189 2 380-392 2004/10
- Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro. Ono K, Hasegawa K, Naiki H, Yamada M. JOURNAL OF NEUROSCIENCE RESEARCH 75 6 742-750 2004/03
- CSF alpha-synuclein levels in dementia with Lewy bodies and Alzheimer's disease Noguchi-Shinohara M, Tokuda T, Yoshita M, Kasai T, Ono K, Nakagawa M, El-Agnaf OM, Yamada M. BRAIN RESEARCH 1251 1-6 2009/01
- Heterogeneity in red wine polyphenolic contents differentially influences Alzheimer's disease-type neuropathology and cognitive deterioration. Journal of Alzheimer's Disease 16 1, 59-72 2009/01
- Identification of antihypertensive drugs which inhibit amyloid-beta protein oligomerization. Journal of Alzheimer's Disease 16 1 49-57 2009/01
- CSF tau protein is a useful marker for effective treatment of superficial siderosis of the central nervous system: two case reports. CLINICAL NEUROLOGY AND NEUROSURGERY 112 1 62-64 2010/01
- Progression of cerebrovascular lesions in pneumococcal meningitis. Sakai K, Ono K, Ohta K, Yamada M 49 12 1261-1262 2010/06
- Anti-amyloidogenic effects of soybean isoflavones in vitro: Fluorescence spectroscopy demonstrating direct binding to A beta monomers, oligomers and fibrils Mie Hirohata,Kenjiro Ono,Jun-ichi Takasaki,Ryoichi Takahashi,Tokuhei Ikeda,Akiyoshi Morinaga,Masahito Yamada BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1822 8 1316 2012/08
- Familial Parkinson disease mutations influence alpha-synuclein assembly Kenjiro Ono,Tokuhei Ikeda,Jun-ichi Takasaki,Masahito Yamada NEUROBIOLOGY OF DISEASE 43 3 715 2011/09
- Vitamin A and Alzheimer's disease Kenjiro Ono,Masahito Yamada GERIATRICS & GERONTOLOGY INTERNATIONAL 12 2 180 2012/04
- Parkinson's disease showing progressive conduction aphasia Kenji Sakai,Kenjiro Ono,Hiromi Harada,Keisuke Shima,Masako Notoya,Masahito Yamada NEUROLOGICAL SCIENCES 33 2 399 2012/04
- Posterior cingulate atrophy and metabolic decline in early stage Alzheimer's disease Shima, K.,Matsunari, I.,Samuraki, M.,Chen, W.-P.,Yanase, D.,Noguchi-Shinohara, M.,Takeda, N.,Ono, K.,Yoshita, M.,Miyazaki, Y.,Matsuda, H.,Yamada, M. Neurobiology of Aging 33 9 2006 2012
- Imaging Findings of Familial Dementia with a Tau R406W Mutation Junji Komatsu,Kenjiro Ono,Daisuke Yanase,Miharu Samuraki,Keisuke Shima,Ryozo Kuwano,Ichiro Matsunari,Masahito Yamada ACTA NEUROLOGICA BELGICA 111 4 374 2011/12
- Phenolic Compounds Prevent Amyloid beta-Protein Oligomerization and Synaptic Dysfunction by Site-specific Binding Kenjiro Ono,Lei Li,Yusaku Takamura,Yuji Yoshiike,Lijun Zhu,Fang Han,Xian Mao,Tokuhei Ikeda,Jun-ichi Takasaki,Hisao Nishijo,Akihiko Takashima,David B. Teplow,Michael G. Zagorski,Masahito Yamada JOURNAL OF BIOLOGICAL CHEMISTRY 287 18 14631 2012/04
- Brain-Targeted Proanthocyanidin Metabolites for Alzheimer's Disease Treatment Jun Wang,Mario G. Ferruzzi,Lap Ho,Jack Blount,Elsa M. Janle,Bing Gong,Yong Pan,G. A. Nagana Gowda,Daniel Raftery,Isabel Arrieta-Cruz,Vaishali Sharma,Bruce Cooper,Jessica Lobo,James E. Simon,Chungfen Zhang,Alice Cheng,Xianjuan Qian,Kenjiro Ono,David B. Teplow,Constantine Pavlides,Richard A. Dixon,Giulio M. Pasinetti JOURNAL OF NEUROSCIENCE 32 15 5144 2012/04
- Preparation of stable Amyloid β-protein oligomers of defined assembly order Clark Rosensweig,Kenjiro Ono,Kazuma Murakami,Devin K. Lowenstein,Gal Bitan,David B. Teplow Methods in Molecular Biology 849 23 2012
- Cervical flexion myelopathy in a patient showing apparent long tract signs: A severe form of Hirayama disease Kenji Sakai,Kenjiro Ono,Yoshiyuki Okamoto,Hideki Murakami,Masahito Yamada JOINT BONE SPINE 78 3 316 2011/05
- Carvedilol as a potential novel agent for the treatment of Alzheimer's disease Jun Wang,Kenjiro Ono,Dara L. Dickstein,Isabel Arrieta-Cruz,Wei Zhao,Xianjuan Qian,Ashley Lamparello,Rakesh Subnani,Mario Ferruzzi,Constantine Pavlides,Lap Ho,Patrick R. Hof,David B. Teplow,Giulio M. Pasinetti NEUROBIOLOGY OF AGING 32 12 2321.e1 2011/12
- Cross-seeding effects of amyloid beta-protein and alpha-synuclein Kenjiro Ono,Ryoichi Takahashi,Tokuhei Ikeda,Masahito Yamada JOURNAL OF NEUROCHEMISTRY 122 5 883 2012/09
- Efficacy of diflunisal on autonomic dysfunction of late-onset familial amyloid polyneuropathy (TTR Va130Met) in a Japanese endemic area Ryoichi Takahashi,Kenjiro Ono,Shutaro Shibata,Keiko Nakamura,Junji Komatsu,Yoshihisa Ikeda,Tokuhei Ikeda,Miharu Samuraki,Kenji Sakai,Kazuo Iwasa,Daiki Kayano,Masahito Yamada JOURNAL OF THE NEUROLOGICAL SCIENCES 345 1-2 231 2014/10
- Improvement in Language Function Correlates with Gait Improvement in Drug-naive Parkinson's Disease Patients Taking Dopaminergic Medication Hidetomo Murakami,Yutaro Momma,Tetsuhito Nohara,Yukiko Mori,Akinori Futamura,Toshihisa Sugita,Seiichiro Ishigaki,Hirotaka Katoh,Machiko Kezuka,Kenjiro Ono,Michael W. Miller,Mitsuru Kawamura JOURNAL OF PARKINSONS DISEASE 6 1 209 2016
- Phenolic compounds prevent the oligomerization of -synuclein and reduce synaptic toxicity Ryoichi Takahashi,Kenjiro Ono,Yusaku Takamura,Mineyuki Mizuguchi,Tokuhei Ikeda,Hisao Nishijo,Masahito Yamada JOURNAL OF NEUROCHEMISTRY 134 5 943 2015/09
- Inclusion body myositis with granuloma formation in muscle tissue Kenji Sakai,Yoshihisa Ikeda,Chiho Ishida,Yasuko Matsumoto,Kenjiro Ono,Kazuo Iwasa,Masahito Yamada NEUROMUSCULAR DISORDERS 25 9 706 2015/09
- Role of intestinal microbiota in the generation of polyphenol-derived phenolic acid mediated attenuation of Alzheimer's disease -amyloid oligomerization Dongjie Wang,Lap Ho,Jeremiah Faith,Kenjiro Ono,Elsa M. Janle,Pamela J. Lachcik,Bruce R. Cooper,Amber H. Jannasch,Bruce R. D'Arcy,Barbara A. Williams,Mario G. Ferruzzi,Samara Levine,Wei Zhao,Lauren Dubner,Giulio M. Pasinetti MOLECULAR NUTRITION & FOOD RESEARCH 59 6 1025 2015/06
- Natural Phenolic Compounds as Therapeutic and Preventive Agents for Cerebral Amyloidosis Masahito Yamada,Kenjiro Ono,Tsuyoshi Hamaguchi,Moeko Noguchi-Shinohara NATURAL COMPOUNDS AS THERAPEUTIC AGENTS FOR AMYLOIDOGENIC DISEASES 863 79 2015
- Effects of antiparkinsonian agents on -amyloid and -synuclein oligomer formation in vitro Kenjiro Ono,Jun-ichi Takasaki,Ryoichi Takahashi,Tokuhei Ikeda,Masahito Yamada JOURNAL OF NEUROSCIENCE RESEARCH 91 10 1371 2013/10
- Unintended Effects of Cardiovascular Drugs on the Pathogenesis of Alzheimer's Disease Jun Wang,Zhong Zhao,Emi Lin,Wei Zhao,Xianjuan Qian,Daniel Freire,Amanda E. Bilski,Alice Cheng,Prashant Vempati,Lap Ho,Kenjiro Ono,Masahito Yamada,Giulio M. Pasinetti PLoS ONE 8 6 e65232 2013/06/06
- Effect of melatonin on alpha-synuclein self-assembly and cytotoxicity Kenjiro Ono,Hideki Mochizuki,Tokuhei Ikeda,Tomoko Nihira,Jun-ichi Takasaki,David B. Teplow,Masahito Yamada NEUROBIOLOGY OF AGING 33 9 2172 2012/09
- Coagulation and fibrinolysis abnormalities in familial amyloid polyneuropathy Ryoichi Takahashi,Kenjiro Ono,Tokuhei Ikeda,Akio Akagi,Daisuke Noto,Ichiro Nozaki,Kenji Sakai,Hidesaku Asakura,Kazuo Iwasa,Masahito Yamada AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS 19 3 129 2012/09
- Exogenous amyloidogenic proteins function as seeds in amyloid β-protein aggregation. Ono K,Takahashi R,Ikeda T,Mizuguchi M,Hamaguchi T,Yamada M Biochimica et biophysica acta 1842 4 646 2014/04
- [Α-synuclein as a biomarker for early diagnosis of Parkinsonism]. Ono K,Yamada M Rinsho shinkeigaku = Clinical neurology 53 11 983 2013
- Cerebral Amyloid Angiopathy-Related Microbleeds Correlate with Glucose Metabolism and Brain Volume in Alzheimer's Disease Samuraki, M.,Matsunari, I.,Yoshita, M.,Shima, K.,Noguchi-Shinohara, M.,Hamaguchi, T.,Ono, K.,Yamada, M. Journal of Alzheimer's Disease 48 2 517 2015
- Exogenous amyloidogenic proteins function as seeds in amyloid beta-protein aggregation Kenjiro Ono,Ryoichi Takahashi,Tokuhei Ikeda,Mineyuki Mizuguchi,Tsuyoshi Hamaguchi,Masahito Yamada BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1842 4 646 2014/04
- [Alpha-Synuclein in blood and cerebrospinal fluid of patients with alpha-synucleinopathy]. Ono K,Yamada M Rinsho byori. The Japanese journal of clinical pathology 62 3 241 2014/03
- Anti-amyloidogenic effects of soybean isoflavones in vitro: Fluorescence spectroscopy demonstrating direct binding to Aβ monomers, oligomers and fibrils. Hirohata M,Ono K,Takasaki J,Takahashi R,Ikeda T,Morinaga A,Yamada M Biochimica et biophysica acta 1822 8 1316 2012/08
- Comparison of FDG PET and structural MRI for the detection of Alzheimer's disease using machine-learning: The Ishikawa Brain Imaging Study Matsunari Ichiro,Samuraki Miharu,Komatsu Junji,Ono Kenjiro,Shinohara Moeko,Hamaguchi Tsuyoshi,Sakai Kenji,Yamada Masahito,Kinuya Seigo JOURNAL OF NUCLEAR MEDICINE 55 2014/05
- Effects of the neurotrophic agent T-817MA on oligomeric amyloid-beta-induced deficits in long-term potentiation in the hippocampal CA1 subfield Yusaku Takamura,Kenjiro Ono,Jumpei Matsumoto,Masahito Yamada,Hisao Nishijo NEUROBIOLOGY OF AGING 35 3 532 2014/03
- Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-gamma coactivator 1 alpha regulated beta-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models Bing Gong,Yong Pan,Prashant Vempati,Wei Zhao,Lindsay Knable,Lap Ho,Jun Wang,Magdalena Sastre,Kenjiro Ono,Anthony A. Sauve,Giulio M. Pasinetti NEUROBIOLOGY OF AGING 34 6 1581 2013/06
- Molecular Topology as Novel Strategy for Discovery of Drugs with A beta Lowering and Anti-Aggregation Dual Activities for Alzheimer's Disease Jun Wang,David Land,Kenjiro Ono,Jorge Galvez,Wei Zhao,Prashant Vempati,John W. Steele,Alice Cheng,Masahito Yamada,Samara Levine,Paolo Mazzola,Giulio M. Pasinetti PLOS ONE 9 3 e92750 2014/03
- Cocoa Extracts Reduce Oligomerization of Amyloid-beta: Implications for Cognitive Improvement in Alzheimer's Disease Jun Wang,Merina Varghese,Kenjiro Ono,Masahito Yamada,Samara Levine,Nikos Tzavaras,Bing Gong,William J. Hurst,Robert D. Blitzer,Giulio Maria Pasinetti JOURNAL OF ALZHEIMERS DISEASE 41 2 643 2014
- Neurolymphomatosis exhibiting repeated exacerbation and remission in both the peripheral and central nervous systems Akio Akagi,Kenjiro Ono,Tsuyoshi Hamaguchi,Miharu Samuraki,Mitsutoshi Nakada,Yukiko Shima,Tetuya Oohata,Masahito Yamada JOURNAL OF THE NEUROLOGICAL SCIENCES 345 1-2 267 2014/10
- Pharmacokinetics, Safety and Tolerability of Melissa officinalisExtract which Contained Rosmarinic Acid in Healthy Individuals: A Randomized Controlled Trial Moeko Noguchi-Shinohara,Kenjiro Ono,Tsuyoshi Hamaguchi,Kazuo Iwasa,Toshitada Nagai,Shoko Kobayashi,Hiroyuki Nakamura,Masahito Yamada PLOS ONE 10 5 e0126422 2015/05
- Effect of pre-processing on diagnostic performance of FDG PET using machine-learning for the detection of Alzheimer's disease: The Ishikawa Brain Imaging Study Matsunari Ichiro,Samuraki Miharu,Komatsu Junji,Ono Kenjiro,Shinohara Moeko,Hamaguchi Tsuyoshi,Sakai Kenji,Yamada Masahito,Kinuya Seigo JOURNAL OF NUCLEAR MEDICINE 55 2014/05
- Myasthenia gravis: Predictive factors associated with the synchronized elevation of anti-acetylcholine receptor antibody titer in Kanazawa, Japan Kazuo Iwasa,Hiroaki Yoshikawa,Miharu Samuraki,Moeko Shinohara,Tsuyoshi Hamaguchi,Kenjiro Ono,Hiroyuki Nakamura,Masahito Yamada JOURNAL OF NEUROIMMUNOLOGY 267 1-2 97 2014/02
- Of Sound Mind and Body: Dietary Lifestyles, Promotion of Healthy Brain Aging, and Prevention of Dementia in Healthy Individuals Giulio Maria Pasinetti,Amanda Bilski,Lap Ho,Jun Wang,Mario Ferruzzi,Masahito Yamada,Kenjiro Ono,Salvatore Mannino Metabolic Syndrome and Neurological Disorders 179 2013/10/11
- Green coffee as a novel agent for Alzheimer's disease prevention by attenuating diabetes Merina Varghese,Lap Ho,Jun Wang,Wei Zhao,Samara Levine,Kenjiro Ono,Salvatore Mannino,Giulio Maria Pasinetti TRANSLATIONAL NEUROSCIENCE 5 2 111 2014/06
- Exacerbation of myasthenia gravis by intravenous peramivir Koji Hayashi,Kazuo Iwasa,Akiyoshi Morinaga,Kenjiro Ono,Masahito Yamada MUSCLE & NERVE 51 6 935 2015/06
- High-speed atomic force microscopy reveals structural dynamics of amyloid beta(1-42) aggregates Takahiro Watanabe-Nakayama,Kenjiro Ono,Masahiro Itami,Ryoichi Takahashi,David B. Teplow,Masahito Yamada PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 113 21 5835 2016/05
- Comparison of FDG PET and structural MRI for the detection of Alzheimer's disease using machine-learning: The Ishikawa Brain Imaging Study Ichiro Matsunari,Miharu Samuraki,Junji Komatsu,Kenjiro Ono,Moeko Shinohara,Tsuyoshi Hamaguchi,Kenji Sakai,Masahito Yamada,Seigo Kinuya JOURNAL OF NUCLEAR MEDICINE 55 2014/05
- Usefulness Differs Between the Visual Assessment and Specific Binding Ratio of 123I-Ioflupane SPECT in Assessing Clinical Symptoms of Drug-Naïve Parkinson's Disease Patients. Murakami H,Kimura A,Yasumoto T,Miki A,Yamamoto K,Ito N,Momma Y,Owan Y,Yano S,Ono K Frontiers in aging neuroscience 10 412 2018
- Cilostazol Suppresses A beta-induced Neurotoxicity in SH-SY5Y Cells through Inhibition of Oxidative Stress and MAPK Signaling Pathway Tatsunori Oguchi,Ran Ono,Mayumi Tsuji,Hidenobu Shozawa,Masayuki Somei,Manami Inagaki,Yukiko Mori,Taro Yasumoto,Kenjiro Ono,Yuji Kiuchi FRONTIERS IN AGING NEUROSCIENCE 9 337 2017/10
- Cerebral Amyloid Angiopathy-Related Microbleeds and Cerebrospinal Fluid Biomarkers in Alzheimer's Disease Moeko Noguchi-Shinohara,Junji Komatsu,Miharu Samuraki,Ichiro Matsunari,Tokuhei Ikeda,Kenji Sakai,Tsuyoshi Hamaguchi,Kenjiro Ono,Hiroyuki Nakamura,Masahito Yamada JOURNAL OF ALZHEIMERS DISEASE 55 3 905 2017
- Tocotrienol-Rich Fraction Modulates Amyloid Pathology and Improves Cognitive Function in A beta PP/PS1 Mice Nor Faeizah Ibrahim,Daijiro Yanagisawa,Lina Wati Durani,Hamizah Shahirah Hamezah,Hanafi Ahmad Damanhuri,Wan Zurinah Wan Ngah,Mayumi Tsuji,Yuji Kiuchi,Kenjiro Ono,Ikuo Tooyama JOURNAL OF ALZHEIMERS DISEASE 55 2 597 2017
- MELAS: Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes Hidetomo Murakami,Kenjiro Ono Brain and Nerve 69 2 111 2017/02/01
- [Clocks, Behavior, and Cognition]. Akinori Futamura,Azusa Shiromaru,Takeshi Kuroda,Motoyasu Honma,Ryuta Kinno,Kenjiro Ono,Mitsuru Kawamura Brain and nerve = Shinkei kenkyu no shinpo 69 6 639 2017/06
- Elevated Serum High-Mobility Group Box-1 Protein Level Is Associated with Poor Functional Outcome in Ischemic Stroke Toshiyuki Tsukagawa,Ryu Katsumata,Mitsugu Fujita,Keizo Yasui,Cassim Akhoon,Kenjiro Ono,Kenji Dohi,Toru Aruga JOURNAL OF STROKE & CEREBROVASCULAR DISEASES 26 10 2404 2017/10
- High-Speed Atomic Force Microscopy of Individual Amyloidogenic Protein Assemblies. Watanabe-Nakayama T,Ono K Methods in molecular biology (Clifton, N.J.) 1814 201 2018
- The Oligomer Hypothesis in alpha-Synucleinopathy Kenjiro Ono NEUROCHEMICAL RESEARCH 42 12 3362 2017/12
- Characteristics of geriatric epilepsy can include dementia Seiichiro Lshigaki,Mitsuru Kawamura,Kenjiro Ono Brain and Nerve 69 10 1125 2017/10/01
- Coexistence of transthyretin- and A beta-type cerebral amyloid angiopathy in a patient with hereditary transthyretin V30M amyloidosis Kenji Sakai,Miwako Asakawa,Ryoichi Takahashi,Chiho Ishida,Ritsuko Nakamura,Tsuyoshi Hamaguchi,Kenjiro Ono,Kazuo Iwasa,Masahito Yamada JOURNAL OF THE NEUROLOGICAL SCIENCES 381 144 2017/10
- Impaired cognitive modification for estimating time duration in Parkinson's disease. Honma M,Masaoka Y,Koyama S,Kuroda T,Futamura A,Shiromaru A,Terao Y,Ono K,Kawamura M PloS one 13 12 e0208956 2018
- Accumulation of I-123-Ioflupane Is a Useful Marker of the Efficacy of Selegiline Monotherapy in Drug-Naive Parkinson's Disease Hidetomo Murakami,Tetsuhito Nohara,Masanobu Uchiyama,Yoshiyuki Owan,Akinori Futamura,Azusa Shiromaru,Setsuro Tsukada,Yu Saito,Takeshi Kuroda,Satoshi Yano,Seiichiro Ishigaki,Hirotaka Katoh,Jiro Munechika,Yoshimitsu Ohgiya,Takehiko Gokan,Kenjiro Ono FRONTIERS IN AGING NEUROSCIENCE 9 321 2017/09
- Time-series analysis: variation of anti-acetylcholine receptor antibody titer in myasthenia gravis is related to incidence of Mycoplasma pneumoniae and influenza virus infections Iwasa, K.,Yoshikawa, H.,Hamaguchi, T.,Sakai, K.,Shinohara-Noguchi, M.,Samuraki, M.,Takahashi, K.,Yanase, D.,Ono, K.,Ishida, C.,Yoshita, M.,Nakamura, H.,Yamada, M. Neurological Research 40 2 102 2018
- Diagonistic Apraxia: A Unique Case of Corpus Callosal Disconnection Syndrome and Neuromyelitis Optica Spectrum Disorder. Hidenobu Shozawa,Akinori Futamura,Yu Saito,Motoyasu Honma,Mitsuru Kawamura,Michael W Miller,Kenjiro Ono Frontiers in neurology 9 653 2018
- Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer's disease-type beta-amyloid neuropathological mechanisms Lap Ho,Kenjiro Ono,Mayumi Tsuji,Paolo Mazzola,Risham Singh,Giulio M. Pasinetti EXPERT REVIEW OF NEUROTHERAPEUTICS 18 1 83 2018
- Effects of word order and morphological information on Japanese sentence comprehension in nonfluent/agrammatic variant of primary progressive aphasia Ryuta Kinno,Yoshitaka Kii,Shinji Kurokawa,Yoshiyuki Owan,Hideyo Kasai,Kenjiro Ono Journal of Neurolinguistics 44 107 2017/11
- Granuloma formation in a patient with GNE myopathy: A case report Keiko Nakamura,Tsuyoshi Hamaguchi,Kenji Sakai,Daisuke Noto,Kenjiro Ono,Yukiko Hayashi,Ichizo Nishino,Masahito Yamada NEUROMUSCULAR DISORDERS 27 2 183 2017/02
- Effects of dopaminergic drug adjustment on executive function in different clinical stages of Parkinson’s disease Hidetomo Murakami,Tetsuhito Nohara,Hidenobu Shozawa,Yoshiyuki Owan,Takeshi Kuroda,Satoshi Yano,Machiko Kezuka,Mitsuru Kawamura,Kenjiro Ono Neuropsychiatric Disease and Treatment 13 2719 2017/10/25
- Efficacy of levetiracetam in primary hemifacial spasm Takeshi Kuroda,Yu Saito,Kazuhisa Fujita,Satoshi Yano,Seiichiro Ishigaki,Hirotaka Kato,Hidetomo Murakami,Kenjiro Ono JOURNAL OF CLINICAL NEUROSCIENCE 34 213 2016/12
- Supratherapeutic concentrations of cilostazol inhibits β-amyloid oligomerization in vitro Hidenobu Shozawa,Tatsunori Oguchi,Mayumi Tsuji,Satoshi Yano,Yuji Kiuchi,Kenjiro Ono Neuroscience Letters 677 19 2018/06/11
- Japanese multicenter database of healthy controls for [123I]FP-CIT SPECT. Hiroshi Matsuda,Miho Murata,Yohei Mukai,Kazuya Sako,Hidetoshi Ono,Hiroshi Toyama,Yoshitaka Inui,Yasuyuki Taki,Hideo Shimomura,Hiroshi Nagayama,Amane Tateno,Kenjiro Ono,Hidetomo Murakami,Atsushi Kono,Shigeki Hirano,Satoshi Kuwabara,Norihide Maikusa,Masayo Ogawa,Etsuko Imabayashi,Noriko Sato,Harumasa Takano,Jun Hatazawa,Ryosuke Takahashi European journal of nuclear medicine and molecular imaging 45 8 1405 2018/07
- Rifampicin is a candidate preventive medicine against amyloid-beta and tau oligomers Tomohiro Umeda,Kenjiro Ono,Ayumi Sakai,Minato Yamashita,Mineyuki Mizuguchi,William L. Klein,Masahito Yamada,Hiroshi Mori,Takami Tomiyama BRAIN 139 Pt 5 1568 2016/05
- Optimization of DARTEL Settings for the Detection of Alzheimer Disease. Komatsu J,Matsunari I,Samuraki M,Shima K,Noguchi-Shinohara M,Sakai K,Hamaguchi T,Ono K,Matsuda H,Yamada M AJNR. American journal of neuroradiology 39 3 473 2018/03
- Differential Effects of the Factor Structure of the Wechsler Memory Scale-Revised on the Cortical Thickness and Complexity of Patients Aged Over 75 Years in a Memory Clinic Setting Ryuta Kinno,Azusa Shiromaru,Yukiko Mori,Akinori Futamura,Takeshi Kuroda,Satoshi Yano,Hidetomo Murakami,Kenjiro Ono FRONTIERS IN AGING NEUROSCIENCE 9 405 2017/12
- The subjective perception of past, present, and future time in patients with Alzheimer's disease: a qualitative study. Shiromaru-Sugimoto A,Murakami H,Futamura A,Honma M,Kuroda T,Kawamura M,Ono K Neuropsychiatric disease and treatment 14 3185 2018
- Agraphia of the left hand with dysfunction of the left superior parietal region without callosal lesions Ryuta Kinno,Hideaki Ohashi,Yukiko Mori,Azusa Shiromaru,Kenjiro Ono eNeurologicalSci 10 16 2018/03/01
- Left Posterior Orbitofrontal Cortex Is Associated With Odor-Induced Autobiographical Memory: An fMRI Study. Keiko Watanabe,Yuri Masaoka,Mitsuru Kawamura,Masaki Yoshida,Nobuyoshi Koiwa,Akira Yoshikawa,Satomi Kubota,Masahiro Ida,Kenjiro Ono,Masahiko Izumizaki Frontiers in psychology 9 687 2018
- Singular case of the driving instructor: Temporal and topographical disorientation. Akinori Futamura,Motoyasu Honma,Azusa Shiromaru,Takeshi Kuroda,Yuri Masaoka,Akira Midorikawa,Michael W Miller,Mitsuru Kawamura,Kenjiro Ono Neurology and clinical neuroscience 6 1 16 2018/01
- Effects of dopaminergic drug adjustment on executive function in different clinical stages of Parkinson's disease Hidetomo Murakami,Tetsuhito Nohara,Hidenobu Shozawa,Yoshiyuki Owan,Takeshi Kuroda,Satoshi Yano,Machiko Kezuka,Mitsuru Kawamura,Kenjiro Ono NEUROPSYCHIATRIC DISEASE AND TREATMENT 13 2719 2017
- New mode of burst spinal cord stimulation improved mental status as well as motor function in a patient with Parkinson's disease. Kobayashi R,Kenji S,Taketomi A,Murakami H,Ono K,Otake H Parkinsonism & related disorders 57 82 2018/07
- Cerebrospinal fluid 5-HIAA concentrations correlate with cardiac uptake of 123I-MIBG during myocardial scintigraphy in drug naïve Parkinson's disease. Murakami H,Yamamoto K,Yasumoto T,Kimura A,Sakae Y,Nomoto S,Kubota S,Watanabe D,Watanabe K,Saito Y,Yano S,Ono K Journal of neural transmission (Vienna, Austria : 1996) 125 10 1511 2018/10
- Coexistence of transthyretin- and A beta-type cerebral amyloid angiopathy in a patient with hereditary transthyretin V30M amyloidosis Sakai Kenji,Asakawa Miwako,Takahashi Ryoichi,Ishida Chiho,Nakamura Ritsuko,Hamaguchi Tsuyoshi,Ono Kenjiro,Iwasa Kazuo,Yamada Masahito BRAIN PATHOLOGY 29 18 2019/02
- Effect of istradefylline on mood disorders in Parkinson's disease. Hiroshi Nagayama,Osamu Kano,Hidetomo Murakami,Kenjiro Ono,Masashi Hamada,Tatsushi Toda,Renpei Sengoku,Yasushi Shimo,Nobutaka Hattori Journal of the neurological sciences 396 78 2019/01/15
- Heterogeneity in gut microbiota drive polyphenol metabolism that influences α-synuclein misfolding and toxicity Ilaria Mogno,Justin Brathwaite,QINGLI WU,Paolo Mazzola,Tal Frolinger,Mayumi Tsuji,Thomas Lloyd,Steven Sims,Susan Westfall,James Simon,Ke Hao,Jeremiah Faith,Kai Ruan,Kenjiro Ono,Eileen Carry,lap ho,Danyue Zhao The Journal of Nutritional Biochemistry 2018/11
- The relationship between thyroid function and cerebral blood flow in mild cognitive impairment and Alzheimer's disease. Nomoto S,Kinno R,Ochiai H,Kubota S,Mori Y,Futamura A,Sugimoto A,Kuroda T,Yano S,Murakami H,Shirasawa T,Yoshimoto T,Minoura A,Kokaze A,Ono K PLoS One 14 4 e0214676 2019/04
- High molecular weight amyloid β1-42 oligomers induce neurotoxicity via plasma membrane damage. Yasumoto T,Takamura Y,Tsuji M,Watanabe-Nakayama T,Imamura K,Inoue H,Nakamura S,Inoue T,Kimura A,Yano S,Nishijo H,Kiuchi Y,Teplow DB,Ono K FASEB journal : official publication of the Federation of American Societies for Experimental Biology 33 8 fj201900604R 2019/05
- High serum high-density lipoprotein-cholesterol is associated with memory function and gyrification of insular and frontal opercular cortex in an elderly memory-clinic population. Kinno R,Mori Y,Kubota S,Nomoto S,Futamura A,Shiromaru A,Kuroda T,Yano S,Ishigaki S,Murakami H,Baba Y,Ono K NeuroImage. Clinical 22 101746 2019/03
- The Cerebellar Leptomeningeal Enhancement Associated with Cryptococcal Meningitis. Shiromaru A,Kinno R,Ito N,Ono K Internal medicine (Tokyo, Japan) 58 1 149 2018/08
- Alzheimer's disease as oligomeropathy. Ono K Neurochemistry international 119 57 2018/10
- [Musical Hallucinosis]. Futamura A,Kawamura M,Ono K Brain and nerve = Shinkei kenkyu no shinpo 70 11 1147 2018/11
- Pharmacological potential of cilostazol for Alzheimer’s disease. Kenjiro Ono,Mayumi Tsuji Frontiers in Pharmacology 10 1 2019/05
- Contraction of distance and duration production in autism spectrum disorder. Honma M,Itoi C,Midorikawa A,Terao Y,Masaoka Y,Kuroda T,Futamura A,Shiromaru A,Ohta H,Kato N,Kawamura M,Ono K Scientific reports 9 1 8806 2019/06
- A New Serum Biomarker Set to Detect Mild Cognitive Impairment and Alzheimer's Disease by Peptidome Technology Koji Abe,Jingwei Shang,Xiaowen Shi,Toru Yamashita,Nozomi Hishikawa,Mami Takemoto,Ryuta Morihara,Yumiko Nakano,Yasuyuki Ohta,Kentaro Deguchi,Masaki Ikeda,Yoshio Ikeda,Koichi Okamoto,Mikio Shoji,Masamitsu Takatama,Motohisa Kojo,Takeshi Kuroda,Kenjiro Ono,Noriyuki Kimura,Etsuro Matsubara,Yosuke Osakada,Yosuke Wakutani,Yoshiki Takao,Yasuto Higashi,Kyoichi Asada,Takehito Senga,Lyang Ja Lee,Kenji Tanaka Journal of Alzheimer's Disease 73 1 217 2020
- Novel VPS13A gene mutations in a South Asian, Indian Patient with Choreaacanthocytosis Akinori Futamura,Masayuki Nakamura,Mitsuru Kawamura,Akira Sano,Kenjiro Ono Neurology India 68 1 206 2020
- Rosmarinic acid suppresses Alzheimer's disease development by reducing amyloid β aggregation by increasing monoamine secretion. Hase T,Shishido S,Yamamoto S,Yamashita R,Nukima H,Taira S,Toyoda T,Abe K,Hamaguchi T,Ono K,Noguchi-Shinohara M,Yamada M,Kobayashi S Scientific reports 9 1 8711 2019/06/18
- Prognostic evaluation of branch atheromatous disease in the pons using carotid artery ultrasonography Seiya Takahashi,Yumika Kokudai,Shinji Kurokawa,Hideyo Kasai,Ryuta Kinno,Yuriko Inoue,Hiromitsu Ezure,Hiroshi Moriyama,Kenjiro Ono,Naruhito Otsuka,Yasuhiko Baba Journal of Stroke and Cerebrovascular Diseases 29 7 104852 2020
- A New Serum Biomarker Set to Detect Mild Cognitive Impairment and Alzheimer's Disease by Peptidome Technology Koji Abe,Jinwei Shang,Xiaowen Shi,Toru hita Yamas,Nozomi Hishikawa,Mami Takemoto,Ryuta Morihara,Yumiko Nakano,Yasuyuki Ohta,Kentaro Deguchi,Masaki Ikeda,Yoshio Ikeda,Koichi Okamoto,Mikio Shoji,Masamitsu Takatama,Motohisa Kojo,Takeshi Kuroda,Kenjiro Ono,Noriyuki Kimura,Etsuro Matsubara,Yosuke Osakada,Yosuke Wakutani,Yoshiki Takao,Yasuto Higashi,Kyoichi Asada,Takehito Senga,Liang-Ja Lee,Kenji Tanaka JOURNAL OF ALZHEIMERS DISEASE 73 1 217 2020
- Nonsystemic vasculitic neuropathy in a patient with IgG-monoclonal gammopathy of undetermined significance: A case report. Ryuta Kinno,Yuyuko Osakabe,Seiya Takahashi,Shinji Kurokawa,Yoshiyuki Owan,Kenjiro Ono,Yasuhiko Baba Medicine 99 5 e19036 2020/01
- Atrial Septal Aneurysm may Cause In-Hospital Recurrence of Cryptogenic Stroke Ayako Kuriki,Yuji Ueno,Yuki Kamiya,Takahiro Shimizu,Ryosuke Doijiri,Yohei Tateishi,Muneaki Kikuno,Yoshiaki Shimada,Hidehiro Takekawa,Eriko Yamaguchi,Masatoshi Koga,Masafumi Ihara,Kenjiro Ono,Akira Tsujino,Koichi Hirata,Kazunori Toyoda,Yasuhiro Hasegawa,Nobutaka Hattori,Takao Urabe Journal of Atherosclerosis and Thrombosis 2020
- Increased Presence of Cerebral Microbleeds Correlates With Ventricular Enlargement and Increased White Matter Hyperintensities in Alzheimer's Disease. Takeshi Kuroda,Motoyasu Honma,Yukiko Mori,Akinori Futamura,Azusa Sugimoto,Satoshi Yano,Ryuta Kinno,Hidetomo Murakami,Kenjiro Ono Frontiers in aging neuroscience 12 13 2020
- Discriminating chorea-acanthocytosis from Huntington's disease with single-case voxel-based morphometry analysis Fumio Suzuki,Noriko Sato,Miho Ota,Atsuhiko Sugiyama,Yoko Shigemoto,Emiko Morimoto,Yukio Kimura,Noritaka Wakasugi,Yuji Takahashi,Akinori Futamura,Mitsuru Kawamura,Kenjiro Ono,Masayuki Nakamura,Akira Sano,Masako Watanabe,Hiroshi Matsuda,Osamu Abe Journal of the Neurological Sciences 408 2020/01/15
- A new computerized assessment battery for cognition (C-ABC) to detect mild cognitive impairment and dementia around 5 min. Moeko Noguchi-Shinohara,Chiaki Domoto,Taketoshi Yoshida,Kozue Niwa,Sohshi Yuki-Nozaki,Miharu Samuraki-Yokohama,Kenji Sakai,Tsuyoshi Hamaguchi,Kenjiro Ono,Kazuo Iwasa,Ichiro Matsunari,Kiyonobu Komai,Hiroyuki Nakamura,Masahito Yamada PloS one 15 12 e0243469 2020
- Pallidal dementia with underlying sleep apnea syndrome: a case report and literature review. Azusa Sugimoto,Hidenobu Shozawa,Keita Mizuma,Sotaro Hieda,Kenjiro Ono Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 41 7 1961 2020/07
- Self- and Cross-Seeding on α-Synuclein Fibril Growth Kinetics and Structure Observed by High-Speed Atomic Force Microscopy. Takahiro Watanabe-Nakayama,Maika Nawa,Hiroki Konno,Noriyuki Kodera,Toshio Ando,David B Teplow,Kenjiro Ono ACS nano 14 8 9979 2020/08/25
- Optic Nerve Tortuosity in Idiopathic Intracranial Hypertension. Sotaro Hieda,Taro Yasumoto,Yumika Kokudai,Kenjiro Ono Internal medicine (Tokyo, Japan) 59 20 2635 2020/10/15
- Three-dimensional Imaging of Abducens Palsy by Neurovascular Compression. Azusa Sugimoto,Takeshi Kuroda,Hiromasa Tsuda,Kenjiro Ono Internal medicine (Tokyo, Japan) 59 2 305 2020/01/15
- Vitamin B12 may prevent Aβ oligomer‐induced neurotoxicity in Alzheimer's disease Atsushi Michael Kimura,Mayumi Tsuji,Taro Yasumoto,Tatsunori Oguchi,Yukiko Mori,Satoshi Yano,Ryuta Kinnno,Shiro Nakamura,Tomio Inoue,David B. Teplow,Yuji Kiuchi,Kenjiro Ono Alzheimer's & Dementia 16 S9 2020/12
- Safety and efficacy of Melissa officinalis extract containing rosmarinic acid in the prevention of Alzheimer's disease progression. Moeko Noguchi-Shinohara,Kenjiro Ono,Tsuyoshi Hamaguchi,Toshitada Nagai,Shoko Kobayashi,Junji Komatsu,Miharu Samuraki-Yokohama,Kazuo Iwasa,Kunihiko Yokoyama,Hiroyuki Nakamura,Masahito Yamada Scientific reports 10 1 18627 2020/10/29
- Differential Effects of a Left Frontal Glioma on the Cortical Thickness and Complexity of Both Hemispheres. Ryuta Kinno,Yoshihiro Muragaki,Takashi Maruyama,Manabu Tamura,Kyohei Tanaka,Kenjiro Ono,Kuniyoshi L Sakai Cerebral cortex communications 1 1 tgaa027 2020
- Mini Review: Correlations of Cognitive Domains With Cerebrospinal Fluid α-Synuclein Levels in Patients With Parkinson's Disease. Hidetomo Murakami,Kenjiro Ono,Tomotaka Shiraishi,Tadashi Umehara,Shusaku Omoto,Yasuyuki Iguchi Frontiers in aging neuroscience 12 616357 2020
- Hippocampus and Parahippocampus Volume Reduction Associated With Impaired Olfactory Abilities in Subjects Without Evidence of Cognitive Decline. Satomi Kubota,Yuri Masaoka,Haruko Sugiyama,Masaki Yoshida,Akira Yoshikawa,Nobuyoshi Koiwa,Motoyasu Honma,Ryuta Kinno,Keiko Watanabe,Natsuko Iizuka,Masahiro Ida,Kenjiro Ono,Masahiko Izumizaki Frontiers in human neuroscience 14 556519 2020
- Recurrent HyperCKemia with Immunological Involvement of the Endomysial Capillaries in Neuromyelitis Optica. Ryuta Kinno,Yuyuko Osakabe,Seiya Takahashi,Shinji Kurokawa,Yoshiyuki Owan,Jun Shimizu,Kenjiro Ono,Yasuhiko Baba Internal medicine (Tokyo, Japan) 59 23 3079 2020/08/04
- Spontaneous MEG activity of the cerebral cortex during eyes closed and open discriminates Alzheimer's disease from cognitively normal older adults. Yoshihisa Ikeda,Mitsuru Kikuchi,Moeko Noguchi-Shinohara,Kazuo Iwasa,Masafumi Kameya,Tetsu Hirosawa,Mitsuhiro Yoshita,Kenjiro Ono,Miharu Samuraki-Yokohama,Masahito Yamada Scientific reports 10 1 9132 2020/06/04
- High-Speed Atomic Force Microscopy Reveals the Structural Dynamics of the Amyloid-β and Amylin Aggregation Pathways. Takahiro Watanabe-Nakayama,Bikash R Sahoo,Ayyalusamy Ramamoorthy,Kenjiro Ono International journal of molecular sciences 21 12 2020/06/16
- Volume of the right supramarginal gyrus is associated with a maintenance of emotion recognition ability Sayaka Wada,Motoyasu Honma,Yuri Masaoka,Masaki Yoshida,Nobuyoshi Koiwa,Haruko Sugiyama,Natsuko Iizuka,Satomi Kubota,Yumika Kokudai,Akira Yoshikawa,Shotaro Kamijo,Sawa Kamimura,Masahiro Ida,Kenjiro Ono,Hidetoshi Onda,Masahiko Izumizaki PLOS ONE 16 7 e0254623 2021/07/22
- Case Report: Paraneoplastic Hashimoto's Encephalopathy Associated With Lymphomatosis Cerebri With Periodic Synchronous Discharges Resembling Creutzfeldt-Jakob Disease. Ryota Amano,Setsuro Tsukada,Shota Kosuge,Satoshi Yano,Kenjiro Ono,Makoto Yoneda,Katsumi Taki Frontiers in neurology 12 701178 2021
- Sex Differences in the Relationship of Serum Vitamin B1 and B12 to Dementia Among Memory Clinic Outpatients in Japan. Ayako Miki,Ryuta Kinno,Hirotaka Ochiai,Satomi Kubota,Yukiko Mori,Akinori Futamura,Azusa Sugimoto,Takeshi Kuroda,Hideyo Kasai,Satoshi Yano,Sotaro Hieda,Akatsuki Kokaze,Kenjiro Ono Frontiers in aging neuroscience 13 667215 2021
- Cerebrospinal fluid cytokines and metalloproteinases in cerebral amyloid angiopathy-related inflammation. Kenji Sakai,Moeko Noguchi-Shinohara,Tokuhei Ikeda,Tsuyoshi Hamaguchi,Kenjiro Ono,Masahito Yamada Acta neurologica Scandinavica 143 4 450 2021/04
- Takotsubo syndrome associated with autoimmune limbic encephalitis: a case report. Yuki Kakinuma,Taro Kimura,Yoshiki Sakae,Satomi Kubota,Kenjiro Ono,Ryuta Kinno BMC cardiovascular disorders 21 1 86 2021/02/11
- Cingulate Island Sign in Single Photon Emission Computed Tomography: Clinical Biomarker Correlations in Lewy Body Disease and Alzheimer's Disease. Akinori Futamura,Sotaro Hieda,Yukiko Mori,Azusa Sugimoto,Hideyo Kasai,Takeshi Kuroda,Satoshi Yano,Kensaku Kasuga,Hidetomo Murakami,Takeshi Ikeuchi,Kenjiro Ono Journal of Alzheimer's disease : JAD 79 3 1003 2021
- Odors Associated With Autobiographical Memory Induce Visual Imagination of Emotional Scenes as Well as Orbitofrontal-Fusiform Activation Yuri Masaoka,Haruko Sugiyama,Masaki Yoshida,Akira Yoshikawa,Motoyasu Honma,Nobuyoshi Koiwa,Shotaro Kamijo,Keiko Watanabe,Satomi Kubota,Natsuko Iizuka,Masahiro Ida,Kenjiro Ono,Masahiko Izumizaki Frontiers in Neuroscience 15 2021/08/03
- Stopwatch training improves cognitive functions in patients with Parkinson's disease. Motoyasu Honma,Hidetomo Murakami,Yoshiko Yabe,Takeshi Kuroda,Akinori Futamura,Azusa Sugimoto,Yasuo Terao,Yuri Masaoka,Masahiko Izumizaki,Mitsuru Kawamura,Kenjiro Ono Journal of neuroscience research 99 5 1325 2021/05
- Numbsense of shape, texture, and objects after left parietal infarction: A case report. Keisuke Hanada,Kayoko Yokoi,Akinori Futamura,Yuji Kinoshita,Kazutaka Sakamoto,Kenjiro Ono,Kazumi Hirayama Journal of neuropsychology 15 2 204 2021/06
- Clinicopathologic Features of Oculopharyngodistal Myopathy With LRP12 CGG Repeat Expansions Compared With Other Oculopharyngodistal Myopathy Subtypes Theerawat Kumutpongpanich,Masashi Ogasawara,Ayami Ozaki,Hiroyuki Ishiura,Shoji Tsuji,Narihiro Minami,Shinichiro Hayashi,Satoru Noguchi,Aritoshi Iida,Ichizo Nishino,Madoka Mori-Yoshimura,Yasushi Oya,Kenjiro Ono,Toshio Shimizu,Akihiro Kawata,Shun Shimohama,Keiko Toyooka,Kaoru Endo,Shuta Toru,Oga Sasaki,Kenji Isahaya,Masanori P. Takahashi,Kazuo Iwasa,Jun-Ichi Kira,Tatsuya Yamamoto,Michi Kawamoto,Tadanori Hamano,Kazuma Sugie,Nobuyuki Eura,Tomo Shiota,Mizuho Koide,Kanako Sekiya,Hideaki Kishi,Takuto Hideyama,Shigeru Kawai,Satoshi Yanagimoto,Hiroyasu Sato,Hajime Arahata,Shigeo Murayama,Kayoko Saito,Hideo Hara,Takashi Kanda,Hiroshi Yaguchi,Noboru Imai,Yuichi Kawagashira,Mitsuru Sanada,Kazuki Obara,Misako Kaido,Minori Furuta,Takashi Kurashige,Wataru Hara,Daisuke Kuzume,Mamoru Yamamoto,Jun Tsugawa,Hitaru Kishida,Naoki Ishizuka,Kohei Morimoto,Yukio Tsuji,Atsuko Tsuneyama,Atsuhiro Matsuno,Ryo Sasaki,Daigo Tamakoshi,Erika Abe,Shinichiro Yamada,Akiyuki Uzawa JAMA Neurology 78 7 853 2021/07/01
- Entorhinal cortex and parahippocampus volume reductions impact olfactory decline in aged subjects. Natsuko Iizuka,Yuri Masaoka,Satomi Kubota,Haruko Sugiyama,Masaki Yoshida,Akira Yoshikawa,Nobuyoshi Koiwa,Motoyasu Honma,Keiko Watanabe,Shotaro Kamijo,Sawa Kamimura,Masahiro Ida,Kenjiro Ono,Masahiko Izumizaki Brain and behavior 11 5 e02115 2021/05
- Serum BDNF as a Potential Biomarker of Alzheimer's Disease: Verification Through Assessment of Serum, Cerebrospinal Fluid, and Medial Temporal Lobe Atrophy Yukiko Mori,Mayumi Tsuji,Tatsunori Oguchi,Kensaku Kasuga,Atsushi Kimura,Akinori Futamura,Azusa Sugimoto,Hideyo Kasai,Takeshi Kuroda,Satoshi Yano,Sotaro Hieda,Yuji Kiuchi,Takeshi Ikeuchi,Kenjiro Ono Frontiers in Neurology 12 2021/04/23
- Myricetin prevents high molecular weight Aβ1-42 oligomer-induced neurotoxicity through antioxidant effects in cell membranes and mitochondria Atsushi Michael Kimura,Mayumi Tsuji,Taro Yasumoto,Yukiko Mori,Tatsunori Oguchi,Yuya Tsuji,Masakazu Umino,Asami Umino,Toru Nishikawa,Shiro Nakamura,Tomio Inoue,Yuji Kiuchi,Masahito Yamada,David B. Teplow,Kenjiro Ono Free Radical Biology and Medicine 171 232 2021/08
- Toxic Amyloid-β42 Conformer May Accelerate the Onset of Alzheimer’s Disease in the Preclinical Stage Akinori Futamura,Sotaro Hieda,Yukiko Mori,Kensaku Kasuga,Azusa Sugimoto,Hideyo Kasai,Takeshi Kuroda,Satoshi Yano,Mayumi Tsuji,Takeshi Ikeuchi,Kazuhiro Irie,Kenjiro Ono Journal of Alzheimer's Disease 1 2021/02/09
- Retinal Amyloid Imaging for Screening Alzheimer's Disease Koh Tadokoro,Toru Yamashita,Shuhei Kimura,Emi Nomura,Yasuyuki Ohta,Yoshio Omote,Mami Takemoto,Nozomi Hishikawa,Ryuta Morihara,Yuki Morizane,Koji Abe,Kenjiro Ono Journal of Alzheimer's Disease 83 2 927 2021
- Review/Advances in Neurological Therapeutics (2020). Dementia Hieda Sotaro,Ono Kenjiro Neurological Therapeutics 38 5 715 2021
- Takotsubo Syndrome: Optimizing Care with a Multidisciplinary Approach. Ryuta Kinno,Kenjiro Ono Journal of multidisciplinary healthcare 14 2487 2021
- A case report of platypnea-orthodeoxia syndrome: A rare condition found during diagnostic workup of a patient with embolic stroke of undetermined sources. Keita Mizuma,Azusa Sugimoto,Yasuhide Mochizuki,Toshiro Shinke,Kenjiro Ono eNeurologicalSci 26 100393 2022/03
- Deterioration after Liver Transplantation and Transthyretin Stabilizer Administration in a Patient with ATTRv Amyloidosis with a Leu58Arg (p.Leu78Arg) TTR Variant. Sadao Hikishima,Kenji Sakai,Akio Akagi,Hiroki Yamaguchi,Shutaro Shibata,Koji Hayashi,Hiroto Nakano,Mizuki Kanemoto,Yuta Usui,Yu Taniguchi,Junji Komatsu,Keiko Nakamura-Shindo,Ichiro Nozaki,Tsuyoshi Hamaguchi,Kenjiro Ono,Kazuo Iwasa,Masahito Yamada Internal medicine (Tokyo, Japan) 2022/03/12
- The Eyes Are More Eloquent Than Words: Anticipatory Looking as an Index of Event Memory in Alzheimer's Disease Yuki Hanazuka,Akinori Futamura,Satoshi Hirata,Akira Midorikawa,Kenjiro Ono,Mitsuru Kawamura Frontiers in Neurology 12 2021/10/15
- Inactivation of seeding activity of amyloid β‐protein aggregates in vitro Hiroto Nakano,Tsuyoshi Hamaguchi,Tokuhei Ikeda,Takahiro Watanabe‐Nakayama,Kenjiro Ono,Masahito Yamada Journal of Neurochemistry 2021/12/20
- Aggregation and structure of amyloid β-protein Kenjiro Ono,Takahiro Watanabe-Nakayama Neurochemistry International 151 105208 2021/12
- Development of a Novel Nutrition-Related Multivariate Biomarker for Mild Cognitive Impairment Based on the Plasma Free Amino Acid Profile. Takeshi Ikeuchi,Yuki Yano,Wataru Sato,Fumiyoshi Morikawa,Shuta Toru,Chika Nishimura,Nobuhiko Miyazawa,Yasuko Kuroha,Ryoko Koike,Shin Tanaka,Kumiko Utsumi,Kensaku Kasuga,Takayoshi Tokutake,Kenjiro Ono,Satoshi Yano,Satoshi Naruse,Ryuji Yajima,Tadanori Hamano,Yuri Yokoyama,Akihiko Kitamura,Eiji Kaneko,Minoru Yamakado,Kenji Nagao Nutrients 14 3 2022/02/01
- Cascade process mediated by left hippocampus and left superior frontal gyrus affects relationship between aging and cognitive dysfunction. Yumika Kokudai,Motoyasu Honma,Yuri Masaoka,Masaki Yoshida,Haruko Sugiyama,Akira Yoshikawa,Nobuyoshi Koiwa,Satomi Kubota,Natsuko Iizuka,Sayaka Wada,Shotaro Kamijo,Yuki Uchida,Satoshi Yano,Masahiro Ida,Kenjiro Ono,Masahiko Izumizaki BMC neuroscience 22 1 75 2021/12/07
- [Recommendations (Proposal) for promoting research for overcoming neurological diseases 2020]. Hideki Mochizuki,Masashi Aoki,Kensuke Ikenaka,Haruhisa Inoue,Takeshi Iwatsubo,Yoshikazu Ugawa,Hitoshi Okazawa,Kenjiro Ono,Osamu Onodera,Kazuo Kitagawa,Yuko Saito,Takayoshi Shimohata,Ryosuke Takahashi,Tatsushi Toda,Jin Nakahara,Riki Matsumoto,Hidehiro Mizusawa,Jun Mitsui,Shigeo Murayama,Masahisa Katsuno,Yoshitsugu Aoki,Hiroyuki Ishiura,Yuishin Izumi,Haruki Koike,Hitoshi Shimada,Yuji Takahashi,Takahiko Tokuda,Hideto Nakajima,Taku Hatano,Sonoko Misawa,Hirohisa Watanabe Rinsho shinkeigaku = Clinical neurology 61 11 709 2021/11/24
- Single-molecule observation of self-propagating amyloid fibrils Takahiro Watanabe-Nakayama,Kenjiro Ono Microscopy 2022/03/07
- The effect of α-tocopherol, α- and γ-tocotrienols on amyloid-β aggregation and disaggregation in vitro. Nor Faeizah Ibrahim,Hamizah Shahirah Hamezah,Daijiro Yanagisawa,Mayumi Tsuji,Yuji Kiuchi,Kenjiro Ono,Ikuo Tooyama Biochemistry and biophysics reports 28 101131 2021/12
- Acquisition and processing of high-speed atomic force microscopy videos for single amyloid aggregate observation Takahiro Watanabe-Nakayama,Kenjiro Ono Methods 197 4 2022/01
- Cerebrospinal Fluid Biomarkers and Amyloid-β Elimination from the Brain in Cerebral Amyloid Angiopathy-Related Inflammation. Kenji Sakai,Moeko Noguchi-Shinohara,Hidetomo Tanaka,Tokuhei Ikeda,Tsuyoshi Hamaguchi,Akiyoshi Kakita,Masahito Yamada,Kenjiro Ono Journal of Alzheimer's disease : JAD 91 3 1173 2023
- Preformed beta-amyloid fibrils are destabilized by coenzyme Q10 in vitro. Ono K, Hasegawa K, Naiki H, Yamada M. 330 1 111-116 2005/04
- The MM2-cortical form of sporadic Creutzfeldt-Jakob disease presenting with visual disturbance. 67 3 531-533 2006/08
- Non-steroidal anti-inflammatory drugs have potent anti-fibrillogenic and fibril-destabilizing effects for alpha-synuclein fibrils in vitro. Hirohata M, Ono K, Morinaga A, Yamada M. 54 3 620-627 2008/03
- Non-steroidal anti-inflammatory drugs as anti-amyloidogenic compounds. Hirohata M, Ono K, Yamada M. 14 30 3280-3294 2008/01
- New therapeutic strategy of amyloidosis Morinaga A, Ono K, Yamada M. 2009
- Microscopic polyangitis presenting with temporal arteritis and multiple cranial neuropathies. 256 1-2 81-83 2007/05
- Hereditary inclusion body myopathy with a novel mutation in the GNE gene associated with proximal leg weakness and necrotizing myopathy. 14 9 e14-5 2007/09
Conference Presentations
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「アルツハイマー病の予防・治療薬の開発」(2004-)
○「有機化合物および生体分子のαシヌクレイン凝集に及ぼす影響の解析」(2006-)
○「アミロイドーシスに関する調査研究」(2009-)
○「脳アミロイドアンギオパチーの生体試料収集に関する研究」(2009-)
○「【アミロイドと異種アミロイド】混合型認知症におけるメタアグリゲート形成と毒性発現」(2023-2025)
○「高速原子間力顕微鏡を用いた凝集タンパクのクロス・シーディング効果の時空間的観察」(2022-2024)
○「医療行為や食品等によるアルツハイマー病の伝播あるいは発症促進に関する研究」(2010-2012)
○「ヒト生体試料のアミロイドβ蛋白オリゴマー形成への影響の解析」(2010-2012)