last modified：2025/09/02
Associate Professor BABA Tomohisa
Faculty, Affiliation
Cancer Research Institute
College and School Educational Field
Division of Medicine, Graduate School of Medical Science
Laboratory
Molecular Bioregulation TEL:076-265-2768 FAX:076-234-4520
Academic Background
【Academic background(Doctoral/Master's Degree)】
Hokkaido University Doctor Gradually School of Medicine 200603 Completed
【Degree】
Doctor of philosophy
Career
postdoctoral fellow(2006/04/01-2007/03/31)
Assistant Professor Cancer Research Institute(2007/04/01-)
Year & Month of Birth
1977/05
Academic Society
Japanese Society for Immunology
Japanese Cancer Association
Award
Specialities
Immunology
Speciality Keywords
immunotolerance
Research Themes
Mechanism of induction of central tolerance by thymic dendritic cells
Books
Papers
- Enlarged PML-nuclear bodies trigger conflicting cell cycle signal-mediated cytotoxicity in leukemia cells. Baba T, Kumamoto S, Moriguchi Y, Morishita S, Hirao A, Johmura Y. Cell Death Dis. 16 1 586 2025/08/02
- The CCL2-CCR2 axis determines whether glomerular endocapillary hypercellularity or wire-loop lesions develop through glomerular macrophage and neutrophil infiltration in lupus nephritis. Zoshima T, Baba T, Nakatani K, Nagata M, Mukaida N, Kawano M. J Pathol. 264 2 174-185 2024/10
- Autophagy Inhibition-induced Cytosolic DNA Sensing Combined with Differentiation Therapy Induces Irreversible Myeloid Differentiation in Leukemia Cells. Baba T, Tomaru U, Hirao A, Mukaida N, Johmura Y. Cancer Res Commun. 4 3 849-860 2024/03/20
- Cancer non-stem cells as a potent regulator of tumor microenvironment: a lesson from chronic myeloid leukemia. Mukaida N, Tanabe Y, Baba T. Mol Biomed. 2 1 7 2021/03/10
- CCR2- and CCR5-mediated macrophage infiltration contributes to glomerular endocapillary hypercellularity in antibody-induced lupus nephritis. Zoshima T, Baba T, Tanabe Y, Ishida Y, Nakatani K, Nagata M, Mukaida N, Kawano M. Rheumatology 61 7 3033-3048 2022/07/06
- Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway. Baba T, Yoshida T, Tanabe Y, Nishimura T, Morishita S, Gotoh N, Hirao A, Hanayama R, Mukaida N. Cell Death Dis. 12 4 322 2021/04/26
- Expansion of senescent megakaryocyte-lineage cells maintains CML cell leukemogenesis. Tanabe Y, Kawamoto S, Takaku T, Morishita S, Hirao A, Komatsu N, Hara E, Mukaida N, Baba T. Blood Adv. 4 24 6157-6188 2020/12/22
- Involvement of Prokineticin 2-expressing Neutrophil Infiltration in 5-Fluorouracil-induced Aggravation of Breast Cancer Metastasis to Lung. Sasaki S, Baba T, Muranaka H, Tanabe Y, Takahashi C, Matsugo S, Mukaida N. Mol Cancer Ther. 17 7 1515-1525 2018/07
- Alveolar Macrophages Drive Hepatocellular Carcinoma Lung Metastasis by Generating Leukotriene B4 Nosaka T, Baba T, Tanabe Y, Sasaki S, Nishimura T, Imamura Y, Yurino H, Hashimoto S, Arita M, Nakamoto Y, Mukaida N. J Immunol. 200 5 1839-1852 2018/03/01
- Essential roles of the interaction between cancer cell-derived chemokine, CCL4, and intra-bone CCR5-expressing fibroblasts in breast cancer bone metastasis. Sasaki S, Baba T, Nishimura T, Hayakawa Y, Hashimoto S, Gotoh N, Mukaida N. Cancer Lett. 378 1 23-32 2016/08/01
- MIP-1α/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice. Baba T, Tanabe Y, Yoshikawa S, Yamanishi Y, Morishita S, Komatsu N, Karasuyama H, Hirao A, Mukaida N. Blood 127 21 2607-2617 2016/05/26
- High-dose cyclophosphamide induces specific tumor immunity with concomitant recruitment of LAMP1/CD107a-expressing CD4-positive T cells into tumor sites. Naito T, Baba T, Takeda K, Sasaki S, Nakamoto Y, Mukaida N. Cancer Lett. 366 1 93-99 2015/09/28
- MIP-1alpha/CCL3-mediated maintenance of leukemia-initiating cells in the initiation process of chronic myeloid leukemia Journal of Experimental Medicine 210 12 2661 2013/11
- Novel process of intrathymic tumor-immune tolerance through CCR2-mediated recruitment of Sirpα+ dendritic cells: a murine model. Baba T,Badr Mel S,Tomaru U,Ishizu A,Mukaida N PLoS One 7 7 e41154 2012/07
- Crucial contribution of thymic Sirp alpha+ conventional dendritic cells to central tolerance against blood-borne antigens in a CCR2-dependent manner. Baba T,Nakamoto Y,Mukaida N J Immunol 183 5 3053-63 2009/09
- Rat CD4+ CD8+ macrophages kill tumor cells through an NKG2D- and granzyme/perforin-dependent mechanism Tomohisa Baba, Sari Iwasaki, Akihiro Ishizu The journal of immunology 180 2999-3006 2008/03
- CD4+/CD8+ macrophages infiltrating at inflammatory sites: a population of monocytes/macrophages with a cytotoxic phenotype Baba Tomohisa, Ishizu Akihiro, Iwasaki Sari Blood 107 2004-2012 2006/03
- Chronic graft-versus-host disease-like autoimmune disorders spontaneously occurred in rats with neonatal thymus atrophy Baba Tomohisa, Ishizu Akihiro, Yoshiki Takashi Eur J Immunol 35 1731-1740 2005/05
- Crucial involvement of the CX3CR1-CX3CL1 axis in dextran sulfate sodium-mediated acute colitis in mice. Kostadinova FI,Baba T,Ishida Y,Kondo T,Popivanova BK,Mukaida N J Leukoc Biol 88 1 133-43 2010/07
Conference Presentations
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「CD4+CD8+マクロファージの抗腫瘍メカニズムと免疫学的役割に関する研究」(2007-2008)
○「胸腺Sirpα+樹状細胞の機能的特徴と自己免疫寛容における役割の解明」(2009-)
○「胸腺Sirpα+樹状細胞による自己免疫寛容の新規誘導メカニズムの解明」(2011-2012)
○「胸腺Sirpα+樹状細胞の機能的特徴と自己免疫寛容における役割の解明」(2009-2010)
○「慢性骨髄性白血病発症における正常骨髄細胞との相互作用機構の解明」(2013-2015)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
Classes (Graduate Schools)
○Seminars on Cytokines(2017)
○Seminars on Cytokines(2017)
○Seminar on Tumor Biology(2016)