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Researcher Information

last modified：2024/01/08

Professor　SUDA Takashi

Mail Laboratory Website

Faculty, Affiliation

Cancer Research Institute
professor

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Natural Sciences, Graduate School of Natural Science and Technology
Division of Medicine, Graduate School of Medical Science
Division of Natural System, Graduate School of Natural Science and Technology

Laboratory

Division of Immunology and Molecular Biology

Academic Background

【Academic background(Doctoral/Master's Degree)】
Osaka University　Doctor　Graduate School, Division of Medicine　1988　Completed
Osaka University　Master　Graduate School, Division of Medicine　1984　Completed
【Academic background(Bachelor's Degree)】
Saitama University　1982

Career

Kanazawa University　Cancer Research Institute　Professor(1998/04/01-)
Osaka Bioscience Institute　Department of Molecular Biology(1995/11/01-1998/03/31)
Osaka Bioscience Institute　Department of Molecular Biology(1992/04/01-1995/10/31)

Year & Month of Birth

Academic Society

Japanese Society for Immunology


The Japanese Society of Cell Death Research
The American Association of Immunologist

Award

Specialities

Experimental Pathology、Immunology、Pathological medical chemistry

Speciality Keywords

Immunology, Apoptosis, Fas ligand, Inflammation, Cancer

Research Themes

Study on the Apoptosis of Cancer Cells.

Study on Immune Regulation by Fas Ligand

Study on the molecular mechanisms of cell death and inflammation

Books

  • 　Apoptosis　2001/06

Papers

  • 　Molecular cloning and expression of the Fas ligand: a novel member of the tumor necrosis factor family　Suda T, Nagata S, et al.　CELL　75　6　1169-1178　1993/12
  • 　Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand　Takahashi T, Suda T, et al.　CELL　76　6　969-976　1994/03
  • 　Lethal effect of the anti-Fas antibody in mice　Ogasawara J, Suda T, et al　NATURE　364　6440　806-809　1993/08
  • 　Fas ligand in human serum.　Tanaka M, Suda T et al.　NATURE MEDICINE　2　3　317-322　1996/03
  • 　Essential roles of the Fas ligand in the development of hepatitis.　Kondo T, Suda T, et al.　NATURE MEDICINE　3　4　409-413　1997/04

show all

  • 　Caspase 1-independent IL-1beta release and inflammation induced by the apoptosis inducer Fas ligand　Miwa K, Suda T, et al.　NATURE MEDICINE　4　11　1287-1292　1998/11
  • 　Caspase-1 initiates apoptosis in the absence of gasdermin D　Tsuchiya K, Nakajima S, Hosojima S, Nguyen DT, Hattori T, Le TM, Hori O, Mahib MR, Yamaguchi Y, Miura M, Kinoshita T, Kushiyama H, Sakurai M, Shiroishi T, and Suda T.　Nat Commun　10　2019/05/07
  • 　Purification and characterization of the Fas-ligand that induces apoptosis　Suda T, Nagata S　JOURNAL OF EXPERIMENTAL MEDICINE　179　3　873-879　1994/03
  • 　Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing　Suda T, Nagata S, et al.　JOURNAL OF EXPERIMENTAL MEDICINE　186　12　2045-2050　1997/12
  • 　Prevention of Hepatocellular Carcinoma Development Associated with Chronic Hepatitis by Anti-Fas Ligand Antibody Therapy　Nakamoto Y, Suda T et al.　JOURNAL OF EXPERIMENTAL MEDICINE　196　8　1105-1111　2002/10
  • 　Caspase-7 mediates caspase-1-induced apoptosis independently of Bid. 　Mahib MR, Hosojima S, Kushiyama H, Kinoshita T, Shiroishi T, Suda T, and Tsuchiya K　Microbiol. Immunol　64　2　143-152　2020/02/01
  • 　Bidirectional crosstalk between neutrophils and adipocytes promotes adipose tissue inflammation　Watanabe Y, Nagai Y, Honda H, Okamoto N, Yanagibashi T, Ogasawara M, Yamamoto S, Imamura R, Takasaki I, Hara H, Sasahara M, Arita M, Hida S, Taniguchi S, Suda T, and Takatsu K　FASEB J　33　11821-11835　2019/11/01
  • 　ASC and NLRP3 maintain innate immune homeostasis in the airway through an inflammasome-independent mechanism　Fang R, Uchiyama R, Sakai S, Hara H, Tsutsui H, Suda T, Mitsuyama M, Kawamura I, and Tsuchiya K　Mucosal Immunol　12　1092-1103　2019/09/01
  • 　Characterization of Innate and Adaptive Immune Responses in PYNOD-deficient mice　1. Nakajima S, Imamura R, Yoshino M, Sakurai M, Tsuchiya K, Sugihara K, Asano M, and Suda T　ImmunoHorizons　2　4　129-141　2018/04/01
  • 　Involvement of p38MAPK in Impaired Neutrophil Bactericidal Activity of Hemodialysis Patients　2. Kamikawa Y, Sakai N, Miyake T, Sagara A, Shinozaki Y, Kitajima S, Toyama T, Hara A, Iwata Y, Shimizu M, Furuichi K, Imamura R, Suda T, Kaneko S, Wada T.　Ther Apher Dial　22　4　345–354　2018/08/01
  • 　Vitamin B6 Prevents IL-1β Protein Production by Inhibiting NLRP3 Inflammasome Activation　Peipei Zhang, Kohsuke Tsuchiya, Takeshi Kinoshita, Hiroko Kushiyama, Sofya Suidasari, Mizuki Hatakeyama, Hisanori Imura, Norihisa Kato and Takashi Suda　Journal of Biological Chemistry　291　47　24517- 24527　2016/11/18
  • 　NLRP3 mediates NF-κB activation and cytokine induction in microbially induced and sterile inflammation　Takeshi Kinoshita, Ryu Imamura, Hiroko Kushiyama, and Takashi Suda　PLoS One　10　e0119179　2015/03/11
  • 　Pyroptotic cells externalize eat-me and release find-me signals and are efficiently engulfed by macrophages　INTERNATIONAL IMMUNOLOGY　25　6　363-372　2013/06
  • 　Roles of the PI3K/Akt pathway and autophagy in TLR3 signaling-induced apoptosis and growth arrest of human prostate cancer cells.　CANCER IMMUNOLOGY IMMUNOTHERAPY　61　5　667-676　2012/05
  • 　Inflammasome and cell death　30　4　566-570　2012/03
  • 　Fas Ligand Has a Greater Impact than TNF-α on Apoptosis and Inflammation in Ischemic Acute Kidney Injury　Nephron Extra　2　1　27-38　2012/01
  • 　Caspase-1 induces apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC)-mediated necrosis independently of its catalytic activity　Kou Motani, Hiroko Kushiyama, Ryu Imamura, Takeshi Kinoshita, Takumi Nishiuchi, and Takashi Suda　JOURNAL OF BIOLOGICAL CHEMISTRY　in press　2011/08
  • 　Activation of ASC induces apoptosis or necrosis depending on the cell type and causes tumor eradication　Kou Motani, Kouji Kawase, Ryu Imamura, Takeshi Kinoshita, Hiroko Kushiyama and Takashi Suda　Cancer Science　101　8　1822-1827　2010/08
  • 　Anti-inflammatory activity of PYNOD and its mechanism in humans and mice　JOURNAL OF IMMUNOLOGY　184　10　2010/05
  • 　Mechanism and repertoire of ASC-mediated gene expression　JOURNAL OF IMMUNOLOGY　182　12　7655-7662　2009/06
  • 　ASC at the crossroad of cell death and inflammation　Experimental Medicine　2008/12
  • 　Expression of NLRP7 (PYPAF3, NALP7)Protein in Endometrial Cancer Tissues　Ohno S, Kinoshita T, Ohno Y, Minamoto T, Suzuki N, Inoue M　ANTICANCER RESEARCH　28　4C　 2493-2497　2008/07
  • 　NLR family: cytoplasmic pathogen sensors　15　5　39-45　2007/08
  • 　Caspase-8- and JNK-dependent AP-1 activation is required for Fas ligand-induced IL-8 production　Matsumoto N, Imamura R, Suda T　EUROPEAN JOURNAL OF BIOCHEMISTRY　274　9　2376-2384　2007/05
  • 　Disease-associated mutations in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cells　Fujisawa A, Suda T, et al.　BLOOD　109　7　2903-2911　2007/04
  • 　Mechanism of ASC-mediated apoptosis: Bid-dependent apoptosis in type II cells　Hasegawa M, Suda T, et al.　ONCOGENE　26　12　1748-1756　2007/03
  • 　IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis BCG infection　Umemura M, Suda T, et al.　JOURNAL OF IMMUNOLOGY　178　6　3786-3796　2007/03
  • 　Fas-associated Factor 1 is a negative regulator of PYRIN-containing Apaf-1-like protein 1　Kinoshita T, Suda T, et al.　INTERNATIONAL IMMUNOLOGY　18　12　1701-1706　2006/12
  • 　General nature of the STAT3-activated anti-inflammatory response　El Kasmi K C, Suda T, et al.　JOURNAL OF IMMUNOLOGY　177　11　7880-7888　2006/12
  • 　Fas ligand induces cell-autonomous IL-23 production indendritic cells, a mechanism for Fas ligand-induced IL-17 production　Kidoya H, Suda T, et al.　JOURNAL OF IMMUNOLOGY　175　12　8024-8031　2005/12
  • 　Apaf-1 like proteins at a crossroads of apoptosis and inflammation　24　9　929-933　2005/08
  • 　PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1b secretion.　Kinoshita T, Suda T, et al　JOURNAL OF BIOLOGICAL CHEMISTRY　280　23　21720-21725　2005/06
  • 　ASC-mediated NF-kB activation leading to IL-8 production requires caspase-8 and is inhibited by CLARP.　Hasegawa M, Suda, T et al　JOURNAL OF BIOLOGICAL CHEMISTRY　280　15　15122-15130　2005/04
  • 　Physiological and pathological roles of apoptosis　63　S4　395-400　2005/04
  • 　Fas ligand induces cell-autonomous NF-kB activation and IL-8 production by a mechanism distinct from that of TNF-a.　Imamura R, Suda T, et al　JOURNAL OF BIOLOGICAL CHEMISTRY　279　45　46415-46423　2004/11
  • 　Involvement of IL-17 in Fas ligand-induced inflammation　Umemura M, Suda T, et al　INTERNATIONAL IMMUNOLOGY　16　8　1099-1108　2004/08
  • 　Fas ligand and inflammation and carcinogenesis　22　11　190-195　2004/07
  • 　PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1.　Wang Y, Suda T, et al　INTERNATIONAL IMMUNOLOGY　16　6　777-786　2004/06
  • 　Different procarcinogenic potentials of lymphocyte subsets in a transgenic mouse model of chronic hepatitis B　Nakamoto Y, Suda T, et al　CANCER RESEARCH　64　9　3326-3333　2004/05
  • 　Pathogen-associated molecular patterns sensitize macrophages to Fas ligand-induced apoptosis and IL-1beta release　Fukui M, Suda T, et al　JOURNAL OF IMMUNOLOGY　171　4　1868-1874　2003/08
  • 　Genomic structure and inducible expression of the IL-22 receptor α chain in mice　Tachiiri A, Suda T, et al　GENES AND IMMUNITY　4　2　153-159　2003/03
  • 　Toll-like receptor 2 contributes to liver injury by Salmonella infection through Fas ligand expression on NKT cells in mice　Shimizu H, Suda T, et al　GASTROENTEROLOGY　123　4　1265-1277　2002/10
  • 　Prevention and induction of autoimmune exocrinopathy is dependent on pathogenic autoantigen cleavage in murine Sjogren's syndrome　Saegusa K. Suda T, et al　JOURNAL OF IMMUNOLOGY　169　2　1050-1057　2002/07
  • 　Requirement of Fas expression in B cells for tolerance induction　Fukuyama H, Suda T, et al　EUROPEAN JOURNAL OF IMMUNOLOGY　32　1　223-230　2002/01
  • 　In vitro prevention of cell-mediated xeno-graft rejection via the Fas/FasL-pathway in CrmA-transducted porcine kidney cells.　Fujino M, Suda T, et al　XENOTRANSPLANTATION　8　2　115-124　2001/05
  • 　The membrane-bound but not the soluble form of human Fas ligand is responsible for its inflammatory activity　Shudo K, Suda T, et al　EUROPEAN JOURNAL OF IMMUNOLOGY　31　8　2504-2511　2001/08
  • 　Possible Role of Organ-Specific Autoantigen for Fas Ligand-Mediated Activation-Induced Cell Death in Murine Sjogren's Syndrome　Ishimaru N, Suda T et al　JOURNAL OF IMMUNOLOGY　167　10　6031-6037　2001/11
  • 　The apoptosis is kin to the inflammation　Experimental Medicine　19　13　198-205　2001/08
  • 　Transgenic expression of Fas in T cells blocks lymphoproliferation but not autoimmune disease in MRL-lpr mice　J Immunol　160　8　3805-3811　1998/04
  • 　Gasdermin D-independent release of interleukin-1β by living macrophages in response to mycoplasmal lipoproteins and lipopeptides　Saeki A, Tsuchiya K, Suda T, Into T, Hasebe A, Suzuki T, and Shibata KI.　Immunology　161　2　114-122　2020/07/23

Conference Presentations

  • Pyroptosis enhances killing of Listeria monocytogenes by ampicillin in vivo.(conference：The 47th Annual Meeting of the Japanese Society for Immunology)(2018/12/10)
  • Caspase-1 initiates apoptosis in the absence of gasdermin D(conference：The 27th Annual Meeting of the Japanese Society for Cell Death Research)(2018/07/27)
  • Caspase-1-induced pyroptosis potentiates anti-tumor immunity(conference：Australia-Japan Meeting on Cell Death)(2018/05/22)
  • Switches between apoptosis and pyroptosis in macrophages and cancer cells(conference：Australia-Japan Meeting on Cell Death)(2018/05/22)
  • Analysis of immune responses in PYNOD deficient mice(2016/12/07)

show all

  • Analysis of the steady-state transport of skin self-antigens in Pynod-Ccr7-double knockout mice(conference：The 24th International Symposium on Molecular Cell Biology of Macrophages)(2016/06/04)

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

○Study on the NLR family

Grant-in-Aid for Scientific Research

○「ビタミンB6の新しい抗炎症作用の解明とその応用に向けた基礎研究」(2015-2015)　
○「パイロトーシスの分子機構と役割」(2014-2018)　
○「炎症抑制型ＮＬＲ蛋白ＰＹＮＯＤの生理的・病理的役割の解明」(2011-2013)　
○「ASCを標的とした癌治療法の開発」(2008-2009)　
○「ASC依存性AP-1活性化機構の解明とASCのがん分子標的としての可能性の検討」(2006-2007)　
○「ASC依存性アポトーシスの分子機構とPYNODの抑制効果の検討」(2005-2005)　
○「PYPAF1/CryopyrinによるNF-κB活性化の制御機構の解明」(2004-2004)　
○「アポトーシス制御にかかわる新規蛋白質の探査」(2000-2001)　
○「Ｆasリガントの炎症誘導作用の分子機構の解析」(1999-1999)　
○「Ｆａｓリガンドの生理的，病理的役割の解析」(1998-1999)　
○「がん細胞が発現するＦａｓリガンドの意義」(1998-1998)　
○「Fas/Fasリガンドシステムの生理的、病理的意義の解析 」(1995-1996)　
○「アポトーシスを誘導する細胞表面抗原:Fasのリガンド遺伝子のクローニング 」(1993-1994)　

Competitive research funding,Contribution

Collaborative research,Consignment study

○Search for natural compounds that activate Apaf-1 like proteins(2005-2006)

Classes (Bachelors)

Classes (Graduate Schools)

○Molecular Oncology(2018)
○Biology of Cancer 2A(2018)
○Biology of Cancer 2B(2018)
○Biology of Cancer 2B(2017)
○Body Defense Mechanisms(2017)
○Body Defense Mechanisms(2017)
○Cancer molecular pathology 2(2017)
○Cancer molecular pathology 2(2017)
○Body Defense Mechanisms(2017)
○Biology of Cancer 2A(2017)
○Cancer molecular pathology 2(2017)
○Cancer molecular pathology 2(2017)
○Molecular Oncology(2017)
○Medical Sciences(2016)
○Body Defense Mechanisms(2016)
○Body Defense Mechanisms(2016)
○Body Defense Mechanisms(2016)
○Biology of Cancer 2B(2016)
○Biology of Cancer 2A(2016)
○Cancer molecular pathology 2(2016)
○Molecular Oncology(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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