Professor YOSHIZAKI Tomokazu
Faculty, Affiliation
Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences
College and School Educational Field
Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
Laboratory
Otolaryngology-Head and neck surgery TEL:076-265-2413 FAX:076-234-4265
Academic Background
【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor Graduate School, Division of Medicine 1991
【Academic background(Bachelor's Degree)】
Kanazawa University 1986
Career
Year & Month of Birth
1961/08
Academic Society
Award
○Zyuzen medical research award(2005/12)
○Hokkoku Cancer Fund(2007/10)
○Cancer treatment fund(2007/11)
○Osaka Cancer Research Fund(2007/12)
○SPIO award(2008/02)
Specialities
Head and neck Tumor、Epstein-Barr Virus、Otorhinolaryngology
Speciality Keywords
Head and neck Tumor Epstein-Barr Virus
Research Themes
Study on Nasopharyngeal Carcinoma and Epstein-Barr Virus
Mechanism of metastasis in head and neck cancer
Extracorporeal shock wave lithotripsy in salivary stones
Books
- Epstein-Barr virus and human cancer 廣川書店 1997
Papers
- Aspirin inhibits tumor cell invasiveness induced by Epstein-Barr virus latent membrane protein 1 through suppression of matrix metalloproteinase-9 expression. Cancer Res. 60 2555-2561 2000
- Association of Epstein-Barr virus infection with p53 accumulation but not bcl-2 protein in nasopharyngeal carcinoma. HISTOPATHOLOGY 34 432-438 1999
- Association of latent membrane protein 1 and matrix metalloproteinase 9 with metastasis in nasopharyngeal carcinoma. CANCER 89 715-723 2000
- Association of vascular endothelial growth factor expression with angiogenesis and lymphnode metastasis in nasopharyngeal carcinoma. LARYNGOSCOPE 109 810-814 1999
- Bilateral jejuno-mesenteric flap for reconstruction of complicated pharyngoesophageal defect. Am. J. Surg. 179 497-499 2001
- Clinical evaluation of staging system for nasopharyngeal carcinoma: Comparison of fourth and fifth edition of UICC TNM classification. Ann. Otol. Rhinol. Laryngol. 109 1125-1129 2000
- c-Met proto-oncogene is induced by Epstein-Barr virus latent membrane protein-1 and correlates with cervical lymphnode metastasis of nasopharyngeal carcinoma. Am. J. Pathol. 159 27-33 2001
- Detection of Epstein-Barr virus in nasopharyngeal carcinoma by in situ hybridization and polymerase chain reaction. LARYNGOSCOPE 107 523-526 1997
- Elevation of antibody against Epstein-Barr virus genes BRLF1 and BZLF1 in nasopharyngeal carcinoma. J. Cancer Res. Clin. Oncol. 126 69-73 2000
- Expression of tissue inhibitor of matrix metalloproteinase-2 correlates with activation of matrx metalloproteinase-2 and predicts poor prognosis in tongue squamous cell carcinoma. Int. J. Cancer 95 44-50 2001
- Increased expression of membrane type 1 - matrix metalloproteinase in head and neck carcinoma. CANCER 79 139-144 1997
- Induction of cyclooxygenase-2 by Epstein-Barr virus latent membrane protein 1 is involved in vascular endothelial growth factor production in nasopharyngeal carcinoma cells. Proc. Natl. Acad. Sci. USA. 98 6905-6910 2001
- Induction of interleukin-8 by Epstein-Barr virus latent membrane pretein-1 and its correlation with angiogenesis in nasopharyngeal carcinoma. Clin. Cancer Res. 7 1946-1951 2001
- Internal carotid artery aneurysm presenting as a large pharyngeal mass. Ann. Otol. Rhinol. Laryngol. 109 690-692 2000
- Leiomyosarcoma of the larynx. J. Laryngol. Otol. 113 167-169 1999
- Malignant myoepithelioma arising from recurrent pleomorphic adenoma of minor salivary gland. Auris Nasus Larynx 29 91-94 2002
- Matrix metalloproteinase 9 expression is induced by Epstein-Barr 1 C - terminal activation region 1 and 2. J. Virol. 73 5548-5555 1999
- Matrix metalloproteinase 9 is induced by the Epstein-Barr virus BZLF1 transactivator. Clin. Exp. Metastasis 17 431-436 1999
- Myofibrosarcoma of the nasal cavity and paranasal sinus. HISTOPATHOLOGY 38 482-484 2001
- The Epstein-Barr virus (EBV) SM protein enhances pre-mRNA processing of the EBV DNA polymerase transcript. J. Virol. 72 8485-8492 1998
- The expression of matrix metalloproteinase 9 is enhanced by Epstein-Barr virus latent membrane protein 1. Proc. Natl. Acad. Sci. USA 95 3621-3626 1998
- Transformation of Madin-Darby canine kidney (MDCK) epithelial cells by Epstein-Barr virus latent membrane protein 1 (LMP1) induces expression of Ets1 and invasive growth. ONCOGENE 19 1764-1771 2000
- アレルギー性鼻炎に対するダレンﾒの効果 耳鼻臨床 91 99-109 1998
- 超選択的動注化学療法による下咽頭喉頭癌治療 ﾐシスプラチン単剤に対するシスプラチン+ピラルビシン併用療法の有効性の検討- 日本気管食道科学会会報 52 400-408 2001
- Expression of Interleukin-8 Receptor A Predicts Poor Outcome in Patients With Nasopharyngeal Carcinoma. 115 1 62-67 2005/01
- Diagnostic value of serum EBV-DNA quantification and antibody to viral capsid antigen in nasopharyngeal carcinoma patients. 95 6 508-513 2004/06
- Epstein-Barr Virus Latent Membrane Protein 1 Induces Synthesis of Hypoxia-Inducible Factor 1{alpha} 24 12 5223-5234 2004/06
- Epstein-Barr Virus (EBV) Latent Membrane Protein 1 Induces Interleukin-8 through the Nuclear Factor-kappaB Signaling Pathway in EBV-Infected Nasopharyngeal Carcinoma Cell Line. 114 5 855-859 2004/01
- Expression of intercellular adhesion molecule (ICAM)-1 in adenoid cystic carcinoma of the head and neck. 113 11 1955-1960 2003/11
- Cleavage of syndecan-1 by membrane type matrix metalloproteinase-1 stimulates cell migration 278 42 40764-70 2003/10
- Epstein-barr virus latent membrane protein 1 induces and causes release of fibroblast growth factor-2. 62 21 6337-44 2002/11
- Modulation of cell growth and matrix metalloproteinase-2 activation of oral squamous cell carcinoma as a function of culture condition with type I collagen. 123 8 987-93 2003/10
Conference Presentations
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「上咽頭癌発癌ならびに多様性獲得分子機構の解析と新規治療法の開発」(2017-2020)
○「頭頸部癌末梢循環腫瘍細胞の量的質的解析を目的とした捕捉チップ開発に関する研究」(2017-2019)
○「代償性増殖による上咽頭癌発癌機構の解明と治療戦略」(2014-2016)
○「新規ドラッグデリバリー理論と新世代シスプラチンによる頭頸部癌治療法の開発」(2014-2016)
○「内因性免疫によるEBV感染制御機構と上咽頭癌発癌機構に関する研究」(2011-2014)
○「ミセル化シスプラチン開発による新規頭頸部癌治療コンセプト」(2011-2013)
○「EBウイルスリボ核酸EBERsによる上咽頭癌発癌機構の分子生物学的解析」(2001-)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Cranial Nerves & Sensory Organ(2018)
○Otolaryngology(BSL)(2018)
○Clinical Oncology(2018)
○Clinical Oncology(2017)
○Cranial Nerves & Sensory Organ(2017)
○Otolaryngology(BSL)(2017)
○Clinical Oncology(2015)
Classes (Graduate Schools)
○Environment and Heredity(2017)
○General Otorhinolaryngology(2017)
○General Otorhinolaryngology(2017)
○General Otorhinolaryngology(2017)
○Medical Sciences(2016)
○General Otorhinolaryngology(2016)
○General Otorhinolaryngology(2016)
○General Otorhinolaryngology(2016)
○Environment and Heredity(2016)